Join Clinical Trials in Pennsylvania

Trial to Compare eConsent With Standard Consent Among Prospective Biobank Participants
NCT04131062
Condition: Lynch Syndrome
Intervention: Behavioral: Electronic Consent (iPad)
Sponsors: Geisinger Clinic; National Cancer Institute (NCI)
Not yet recruiting
4Kscore Using Serum Stored Uncentrifuged
NCT04130776
Condition: Prostate Cancer
Intervention: Diagnostic Test: Measurement of four prostate-specific kallikreins for the 4Kscore Test when serum stored uncentrifuged
Sponsor: OPKO Health, Inc.
Completed
New Foods Take Time, a Curriculum Designed to Promote Tasting and Liking of Fruits and Vegetables
NCT04129372
Condition: Eating Behavior
Intervention: Behavioral: New Foods Take Time
Sponsor: Penn State University
Enrolling by invitation
Improvement in Endothelial Dysfunction After Initiation of Anti-arrhythmic Therapy in Atrial Fibrillation Patients
NCT04128878
Condition: Atrial Fibrillation
Interventions: Drug: Sotalol; Drug: Dofetilide
Sponsor: University of Pittsburgh
Recruiting
Evaluating a Mindful Eating Curriculum, "Savor the Flavor"
NCT04127812
Condition: Eating Behavior
Intervention: Behavioral: Savor the Flavor
Sponsor: Penn State University
Enrolling by invitation
Using Continuous Glucose Monitoring to Detect and Intervene on Maintenance Factors for Trans-diagnostic Binge Eating Pathology
NCT04126694
Conditions: Bulimia Nervosa; Binge Eating
Intervention: Behavioral: CBT with smartphone application SenseSupport
Sponsor: Drexel University
Not yet recruiting
Investigating the Experience of Living With Down Syndrome and Obstructive Sleep Apnea Syndrome (Stage 1)
NCT04124471
Conditions: Down Syndrome; Obstructive Sleep Apnea
Intervention: Behavioral: Open-ended semi-structured interviews
Sponsors: Children's Hospital of Philadelphia; National Institutes of Health (NIH); National Heart, Lung, and Blood Institute (NHLBI); University of Pennsylvania; Children's Hospital Medical Center, Cincinnati
Recruiting
Pharmacist-led Transitions of Care in the Outpatient Oncology Infusion Center for Patients With Solid Tumor
NCT04122118
Condition: Malignant Solid Neoplasm
Interventions: Other: Medical Chart Review; Other: Educational Intervention; Other: Survey Administration
Sponsor: Thomas Jefferson University
Recruiting
Ocular Inflammation in Cataract Patients and Response to Treatment With Xiidra
NCT04120987
Condition: Dry Eye
Intervention: Drug: Lifitegrast 5% Ophthalmic Solution
Sponsor: Bucci Laser Vision Institute
Enrolling by invitation
Randomized Clinical Trial to Increase Physical Activity After a a Hypertensive Pregnancy
NCT04119232
Conditions: Hypertension in Pregnancy; Preeclampsia; Gestational Hypertension
Intervention: Behavioral: Social incentives-based program
Sponsor: University of Pennsylvania
Not yet recruiting
Evaluating the Efficacy of Pediatric Lipid Screening Alerts
NCT04118348
Conditions: Hypercholesterolemia; Hypercholesterolemia, Familial; Hypercholesteremia in Children; Hyperlipidemia in Children
Interventions: Behavioral: Best Practice Alert; Behavioral: Health Maintenance Topic
Sponsor: Geisinger Clinic
Not yet recruiting
Mohs Micrographic Surgery and Reconstruction in the Optum Insurance Claims Database
NCT04117373
Conditions: Skin Cancer; Mohs Micrographic Surgery; Interpolated Flap Repair
Intervention:
Sponsor: University of Pennsylvania
Active, not recruiting
Evaluation of 18F-fluciclovine (FACBC) PET/MR Uptake in Participants With Glioma
NCT04114370
Condition: Glioma
Intervention: Drug: 18F-fluciclovine
Sponsors: James Mountz; Blue Earth Diagnostics
Not yet recruiting
Acceptance and Commitment Therapy vs. Supportive Psychotherapy With Cystic Fibrosis Patients
NCT04114227
Condition: Cystic Fibrosis
Interventions: Behavioral: Acceptance and Commitment Therapy adapted for Cystic Fibrosis (ACT with CF); Behavioral: Supportive Psychotherapy (Treatment as Usual Control)
Sponsor: Drexel University
Recruiting
Anti-PD-1 mAb Plus Metabolic Modulator in Solid Tumor Malignancies
NCT04114136
Conditions: Melanoma; Renal Cell Carcinoma; NSCLC; Hepatocellular Carcinoma; Urothelial Cancer; Gastric Adenocarcinoma; HNSCC; Esophageal Adenocarcinoma; Microsatellite Instability-High Solid Malignant Tumor
Interventions: Drug: Nivolumab or Pembrolizumab (dependent upon approved indication); Drug: Metformin; Drug: Rosiglitazone
Sponsor: Dan Zandberg
Not yet recruiting
Phase 2A Study of Ad5.F35-hGCC-PADRE in Gastrointestinal Malignancies
NCT04111172
Conditions: Pancreatic Ductal Adenocarcinoma; Colorectal Adenocarcinoma; Gastric Adenocarcinoma; Esophageal Adenocarcinoma
Intervention: Biological: Ad5.F35-hGCC-PADRE
Sponsor: Thomas Jefferson University
Not yet recruiting
Enhanced Recovery After Surgery in Kidney Transplant Donors
NCT04110080
Conditions: Opioid Use; Kidney Diseases; Pain, Postoperative; Postoperative Complications; Postoperative Nausea and Vomiting
Interventions: Procedure: multimodal pain management; Other: goal directed fluid management; Other: preoperative carbohydrate loading; Procedure: Donor nephrectomy; Procedure: regional anesthesia
Sponsor: Thomas Jefferson University
Recruiting
A Study to Evaluate the Safe and Effective Use of the Prefilled Safety Syringe or the Auto-injector for the Subcutaneous Self-injection of Bimekizumab Solution by Subjects With Active Psoriatic Arthritis
NCT04109976
Condition: Psoriatic Arthritis
Intervention: Drug: Bimekizumab
Sponsor: UCB Biopharma S.P.R.L.
Enrolling by invitation
School Adolescent Mood Project: Efficacy of Counselor-Implemented IPT-AST
NCT04109716
Condition: Depressive Symptoms
Interventions: Behavioral: Interpersonal Psychotherapy - Adolescent Skills Training; Behavioral: Services as usual
Sponsors: Children's Hospital of Philadelphia; Institute of Education Sciences
Recruiting
Sleep in Pediatric HSCT
NCT04106089
Conditions: Sleep; Stem Cell Transplant Complications
Intervention: Behavioral: Extended time between vitals check
Sponsors: Children's Hospital of Philadelphia; Rutgers University
Recruiting
Adolescent Attention to Emotion Study
NCT04105868
Condition: Depression
Intervention: Other: Neurofeedback
Sponsors: University of Pittsburgh; National Institute of Mental Health (NIMH)
Recruiting
Molecular Imaging of the Underlying Mechanism of Cardiotoxicity in Patients With Light Chain Amyloidosis Using PET/CT
NCT04105634
Condition: Cardiac Amyloidosis
Interventions: Drug: FNOS; Drug: Florbetaben
Sponsor: University of Pennsylvania
Not yet recruiting
Tracheostomy Change
NCT04105387
Condition: Tracheostomy
Intervention: Procedure: Early Tracheostomy Change
Sponsor: Children's Hospital of Philadelphia
Recruiting
Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis
NCT04102371
Conditions: Shock; Septic
Interventions: Drug: Lactated Ringer; Drug: Normal Saline
Sponsors: Children's Hospital of Philadelphia; University of Pittsburgh
Not yet recruiting
Exercise Prescription for the Improvement of Quality of Life in Elderly Patients With Multiple Myeloma
NCT04100044
Condition: Plasma Cell Myeloma
Interventions: Other: Exercise Counseling; Behavioral: Exercise Intervention; Other: Questionnaire administration; Other: Quality-of-Life Assessment
Sponsor: Thomas Jefferson University
Not yet recruiting
Throwing Device Trial
NCT04098107
Condition: Overuse Injury
Intervention: Device: Throwing Device
Sponsors: Children's Hospital of Philadelphia; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting
Investigation of the Gut Microbiome on Statin Response
NCT04098003
Condition: Healthy Volunteers
Interventions: Drug: Rosuvastatin; Drug: Placebo
Sponsor: Sony Tuteja
Recruiting
Expect Respect Middle School Randomized Trial
NCT04095429
Conditions: Adolescent Behavior; Violence in Adolescence; Group, Peer; Violence, Non-accidental; Violence, Sexual; Violence, Physical; Violence, Domestic; Emotional Abuse; Coping Skills; Communication, Personal
Interventions: Behavioral: Expect Respect; Behavioral: Enhanced Usual Care
Sponsors: University of Pittsburgh; Centers for Disease Control and Prevention
Recruiting
Bicycle Exercise Echocardiography to Assess Physiological Significance of Mitral Annular Calcification
NCT04093973
Condition: Mitral Annulus Calcification
Intervention: Diagnostic Test: bicycle stress echocardiography
Sponsors: Albert Einstein Healthcare Network; Lantheus Medical Imaging
Recruiting
Use of Virtual Reality for Overdose Management Educational Trainings
NCT04091659
Conditions: Drug Overdose; Virtual Reality
Interventions: Other: Virtual Reality Education; Other: Standard Education
Sponsor: University of Pennsylvania
Enrolling by invitation
Optimize PRO Study
NCT04091048
Condition: Symptomatic Aortic Stenosis
Intervention: Device: Evolut™ PRO System
Sponsor: Medtronic Cardiovascular
Recruiting
VNS-supplemented Motor Retraining After Stroke
NCT04088578
Condition: Stroke, Acute
Interventions: Other: Training; Other: Vagus Nerve Stimulation; Other: Sham Stimulation
Sponsor: University of Pittsburgh
Not yet recruiting
VNS-induced Corticospinal Plasticity
NCT04088565
Condition: Stroke
Interventions: Other: Paired-Associative Stimulation (PAS); Other: Vagus Nerve Stimulation (VNS); Other: Sham Stimulation
Sponsor: University of Pittsburgh
Not yet recruiting
Restoring Molecular Circadian Rhythm
NCT04086589
Conditions: Healthy Young; Healthy Elderly
Intervention: Other: Observational study without intervention
Sponsor: University of Pennsylvania
Recruiting
Use of PECS Block in Partial Mastectomy for Postoperative Pain Control and Mitigation of Narcotic Use- A Randomized Control Trial
NCT04086394
Conditions: Breast Cancer; Partial Mastectomy; Postoperative Pain; Opioid Use; Local Anesthesia
Interventions: Procedure: Pectoral Nerve Block; Procedure: Surgery without Nerve Block
Sponsor: Main Line Health
Recruiting
Remote Electronic Patient Monitoring in Oncology Patients
NCT04086251
Condition: Cancer
Intervention: Other: Gaido
Sponsors: Gaido Health; The Guthrie Clinic
Enrolling by invitation
Sickle Cell Disease and CardiovAscular Risk - Red Cell Exchange Trial (SCD-CARRE)
NCT04084080
Condition: Sickle Cell Disease
Interventions: Biological: Red Blood Cell; Other: Standard of care
Sponsors: Mark Gladwin; National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting
Identifying Student Opinion Leaders to Lead E-cigarette Interventions
NCT04083469
Conditions: E-Cig Use; Adolescent Behavior
Interventions: Behavioral: Peer-Led Peer-Elected Intervention; Behavioral: Adult-Led Intervention; Behavioral: Peer-Led Non-Elected Intervention
Sponsors: University of Pittsburgh; University of Pittsburgh Medical Center
Not yet recruiting
Dining With Diabetes in Pennsylvania
NCT04080960
Condition: Diabetes Mellitus, Type 2
Intervention: Behavioral: Lifestyle modification education
Sponsor: Penn State University
Recruiting
Study of Safety and Tolerability of Nivolumab Treatment Alone or in Combination With Relatlimab or Ipilimumab in Head and Neck Cancer
NCT04080804
Condition: Head and Neck Squamous Cell Carcinoma (HNSCC)
Interventions: Drug: Nivolumab; Drug: Relatlimab; Drug: Ipilimumab
Sponsors: Robert Ferris; Bristol-Myers Squibb
Not yet recruiting
Biological Response to Brief Psychological Challenge
NCT04078035
Condition: Acute Inflammatory Response to Psychological Stress
Interventions: Behavioral: Socio-evaluative speech task, then Control; Behavioral: Control, then Socio-evaluative speech task
Sponsors: University of Pittsburgh; National Institute of Mental Health (NIMH)
Not yet recruiting
Volume vs Concentration: Quadratus Lumborum Blocks With High Volume/Low Concentration or Low Volume/ High Concentration in Nephrectomies
NCT04077398
Conditions: Analgesia; Postoperative Pain; Block
Intervention: Drug: Ropivacaine 0.5% Injectable Solution
Sponsor: Bruce Ben-David
Not yet recruiting
Memory-Updating Technique to Reduce Food Craving and High Calorie Food Intake Among Individuals With Overweight/Obesity
NCT04077385
Conditions: Overweight; Obesity; Craving; Eating Behavior
Interventions: Behavioral: Retrieval-extinction (R-E) Training; Behavioral: Extinction Training
Sponsors: University of Pittsburgh; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Not yet recruiting
Efficacy of Brock String Therapy Post Concussion
NCT04076657
Conditions: Concussion, Brain; Near Point Convergence
Interventions: Behavioral: Brock String Therapy; Behavioral: Standard of Care
Sponsor: University of Pittsburgh
Not yet recruiting
Augmenting Cognitive Behavioral Therapy With Inhibitory Control Training
NCT04076553
Conditions: Binge-Eating Disorder; Bulimia Nervosa
Interventions: Behavioral: CBT; Behavioral: ICT
Sponsor: Drexel University
Recruiting
Atrial Fibrillation Health Literacy and Information Technology Trial in Rural PA Counties
NCT04076020
Conditions: Atrial Fibrillation; Familial Atrial Fibrillation; Arrhythmia, Cardiac; Heart Diseases; Pathologic Processes
Interventions: Behavioral: Relational agent/AliveCor Kardia - Intervention Group; Behavioral: Usual Care
Sponsors: University of Pittsburgh; National Heart, Lung, and Blood Institute (NHLBI); Northeastern University; Boston University
Not yet recruiting
Atrial Fibrillation Health Literacy and Information Technology Trial in Pittsburgh, PA
NCT04075994
Conditions: Atrial Fibrillation; Familial Atrial Fibrillation; Arrythmia, Cardiac; Heart Diseases; Pathologic Processes
Interventions: Behavioral: Relational Agent and heart rate and rhythm monitor; Behavioral: Usual Care
Sponsors: University of Pittsburgh; National Heart, Lung, and Blood Institute (NHLBI); Northeastern University; Boston University
Not yet recruiting
Healthy Eating ASD
NCT04075552
Condition: Food Selectivity
Interventions: Behavioral: Pre Meal Presentation; Behavioral: Pre Meal Presentation + Modeling; Behavioral: Pre Meal Presentation + Token Economy
Sponsor: Penn State University
Recruiting
Heart at Work Study
NCT04075279
Conditions: Occupational Diseases; Cardiovascular Diseases; Cardiovascular Risk Factor; Occupational Exposure
Intervention:
Sponsor: University of Pittsburgh
Not yet recruiting
A Pilot Study of Teacher-Child Interaction Training - Universal in Head Start
NCT04075071
Conditions: Child Behavior; Child Development; Child Behavior Problem
Intervention: Behavioral: Teacher-Child Interaction Training - Universal
Sponsors: Children's Hospital of Philadelphia; PNC Foundation
Recruiting
Study of ARRY-614 Plus Either Nivolumab or Ipilimumab
NCT04074967
Conditions: Renal Cell Carcinoma; Melanoma; Solid Tumor
Interventions: Drug: Phase Ib ARRY-614 + nivolumab; Drug: Phase Ib ARRY-614 + ipilimumab; Drug: Phase II ARRY-614 + ipilimumab; Drug: Phase II ARRY-614 + nivolumab (melanoma); Drug: Phase II ARRY-614 + nivolumab (RCC)
Sponsors: Jason J. Luke, MD; Array BioPharma
Not yet recruiting
Prospective Breast Cancer Biospecimen Collection
NCT04074720
Conditions: Breast Cancer; Invasive Breast Cancer; Carcinoma in Situ of the Breast
Interventions: Procedure: Tissue Sample collection; Other: Blood Sample Collection; Other: Rectal Swab
Sponsor: Thomas Jefferson University
Recruiting
Chronic Insomnia and CSF Markers of Dementia - Effects of Treatment
NCT04073992
Condition: Insomnia Chronic
Intervention: Behavioral: cognitive behavioral treatment of insomnia
Sponsor: University of Pennsylvania
Recruiting
Evaluation of Fidaxomicin in the Treatment of Clostridium Difficile Infection (CDI)
NCT04070352
Condition: Clostridium Difficile Infection (CDI)
Intervention: Drug: Fidaxomicin
Sponsors: University of Pittsburgh; Merck Sharp & Dohme Corp.
Active, not recruiting
Mindful Response to Adversity: A Brief Stress Resilience Training
NCT04064372
Conditions: Loneliness; Depression
Interventions: Behavioral: Mindful response to adversity brief training; Behavioral: Strengths-based response to adversity brief training
Sponsor: Carnegie Mellon University
Enrolling by invitation
Evaluation of Neuroinflammation in Parkinson's Disease Using 18F-NOS PET/CT
NCT04062526
Conditions: Parkinson Disease; Healthy Volunteer
Intervention: Drug: [18F]NOS
Sponsor: University of Pennsylvania
Recruiting
Memory & Conditioning Under Anesthesia
NCT04062123
Conditions: Anesthesia; Pain
Interventions: Drug: Dexmedetomidine; Drug: Propofol; Drug: Fentanyl; Device: Peripheral Nerve Stimulation; Drug: Placebo
Sponsor: Keith M. Vogt, MD, PhD
Not yet recruiting
Quinine Topical Nasal Spray to Prevent Sinusitis After Endoscopic Sinus Surgery
NCT04060316
Condition: Sinusitis Chronic
Interventions: Drug: Quinine; Drug: Placebo
Sponsor: GeneOne Life Science, Inc.
Not yet recruiting
Low Nicotine Cigarettes Plus Electronic Cigarettes
NCT04058717
Condition: Tobacco Dependence
Interventions: Other: Normal Nicotine Content research cigarettes; Other: High Nicotine e-cigarette; Other: Very Low Nicotine Content research cigarettes; Other: Zero Nicotine e-cigarette
Sponsor: Milton S. Hershey Medical Center
Not yet recruiting
Digital Self-Management and Health Coaching for Type 2 Diabetes - Impact on Diabetes Clinical and Wellness Indicators
NCT04057248
Condition: Diabetes Mellitus, Type 2
Interventions: Device: Dario Blood Glucose Monitoring System; Behavioral: CDE
Sponsor: LabStyle Innovations Ltd.
Completed
Ivosidenib (AG-120) With Nivolumab in IDH1 Mutant Tumors
NCT04056910
Conditions: Advanced Solid Tumor; IDH1 Mutation; Glioma
Intervention: Drug: ivosidenib and nivolumab
Sponsors: Jason J. Luke, MD; Agios Pharmaceuticals, Inc.; Bristol-Myers Squibb (BMS)
Not yet recruiting
Pistachios Blood Sugar Control, Heart and Gut Health
NCT04056208
Conditions: Type 2 Diabetes; Cardiovascular Diseases
Interventions: Drug: Pistachio; Other: Usual care
Sponsor: Penn State University
Recruiting
Study to Assess TOPO2A as a Biomarker for Sensitivity to Doxorubicin/Doxil in Soft Tissue Sarcoma
NCT04055753
Condition: Soft Tissue Sarcoma
Interventions: Drug: Doxil; Drug: Doxorubicin
Sponsor: Fox Chase Cancer Center
Recruiting
Utilization of Telehealth to Improve Adherence to Adjuvant Endocrine Therapy in Breast Cancer Patients
NCT04054557
Conditions: Estrogen Receptor-positive Breast Cancer; Progesterone Receptor Positive Breast Cancer; Stage 0 Breast Cancer AJCC v6 and v7; Stage I Breast Cancer AJCC v7; Stage IA Breast Cancer AJCC v7; Stage IB Breast Cancer AJCC v7; Stage II Breast Cancer AJCC v6 and v7; Stage IIA Breast Cancer AJCC v6 and v7; Stage IIB Breast Cancer AJCC v6 and v7; Stage IIIA Breast Cancer AJCC v7; Stage IIIB Breast Cancer AJCC v7; Stage IIIC Breast Cancer AJCC v7
Interventions: Other: Telemedicine; Other: Best Practice; Other: Questionnaire Administration; Other: Quality-of-Life Assessment
Sponsor: Thomas Jefferson University
Recruiting
The Efficacy of Physical Activity on Improving Health Outcomes for Renal Transplant Patients and Their Caregivers
NCT04054323
Condition: Chronic Kidney Diseases
Intervention: Behavioral: Physical Activity Intervention
Sponsor: University of Pittsburgh
Not yet recruiting
METEOR Think NIV Pilot
NCT04052542
Condition: Acute Respiratory Failure
Interventions: Behavioral: Traditional online continuing education; Behavioral: Interprofessional education; Behavioral: Just-in-time education
Sponsors: University of Pittsburgh; National Heart, Lung, and Blood Institute (NHLBI)
Recruiting
Enhanced Bioscaffold for Volumetric Muscle Loss
NCT04051242
Condition: Muscle Loss
Intervention: Device: XenMatrix™ AB Surgical Graft
Sponsors: J. Peter Rubin, MD; Medical Technology Enterprise Consortium (MTEC)
Not yet recruiting
Move to Improve Physical Activity in Parkinson's Disease
NCT04051151
Conditions: Parkinson Disease; Apathy
Intervention: Behavioral: Gameficiation
Sponsor: University of Pennsylvania
Recruiting
tDCS to Treat Subacute Aphasia
NCT04048668
Conditions: Aphasia; Stroke, Acute
Intervention: Device: Transcranial Direct Current Stimulation (tDCS)
Sponsor: University of Pennsylvania
Enrolling by invitation
Topical KB105 Gene Therapy for the Treatment of TGM1-deficient Autosomal Recessive Congenital Ichthyosis (ARCI)
NCT04047732
Condition: TGM-1 Related Autosomal Recessive Congenital Ichthyosis
Intervention: Biological: KB105
Sponsor: Krystal Biotech, Inc.
Recruiting
Assessing the Impact of myHealth Rewards New Hire Enrollment Emails
NCT04047342
Conditions: Health Promotion; Wellness Programs
Interventions: Behavioral: Welcome email; Behavioral: Loss frame
Sponsor: Geisinger Clinic
Active, not recruiting
A Study to Evaluate Patient Characteristics and Treatment Patterns Among Rheumatoid Arthritis Patients
NCT04047121
Condition: Rheumatoid Arthritis
Intervention:
Sponsor: Pfizer
Active, not recruiting
Treating Primary Progressive Aphasia (PPA) Using High-definition tDCS
NCT04046991
Condition: Primary Progressive Aphasia
Interventions: Device: high-definition transcranial direct current stimulation; Behavioral: modified constraint-induced language therapy
Sponsor: University of Pennsylvania
Not yet recruiting
The Parenting With Depression Study
NCT04045132
Conditions: Postpartum Depression; Parenting; Parent-Child Relations
Interventions: Behavioral: Social Media-Based Parenting Program; Behavioral: MoodGym
Sponsors: Children's Hospital of Philadelphia; National Institute of Mental Health (NIMH)
Not yet recruiting
Magnetic Stimulation to Treat VT Storm
NCT04043312
Condition: Ventricular Tachycardia
Intervention: Device: Magstim SuperRapid
Sponsor: University of Pennsylvania
Recruiting
Novel Guidance Device for Image Fusion and Needle Guidance in Lung, Liver or Kidney Biopsy
NCT04039529
Conditions: Liver Biopsy; Lung Biopsy; Kidney Biopsy
Intervention: Device: SCENERGY-guided Biopsy
Sponsors: Clear Guide Medical; Temple University Hospital; National Institutes of Health (NIH)
Recruiting
Symptomatic Management of Lyme Arthritis
NCT04038346
Conditions: Lyme Arthritis; Lyme Disease; Arthritis
Interventions: Drug: Naproxen; Drug: Acetaminophen
Sponsor: Desiree Neville, MD
Recruiting
Ketamine to Improve Recovery After Cesarean Delivery - Part 1
NCT04037085
Conditions: Obstetric Pain; Postpartum Depression; Breastfeeding; Pain, Acute; Pain, Chronic; Obstetric Anesthesia Problems; Drug Effect; Opioid Use
Intervention: Drug: Ketamine
Sponsors: Grace Lim, MD, MS; University of Pittsburgh
Recruiting
Buddy Relationships in DermatoloGic Excisions for Skin Cancer
NCT04036344
Conditions: Skin Cancer Face; Quality of Life; Surgical Wound; Peer Mentorship
Intervention: Behavioral: Peer Mentorship Program
Sponsor: Abramson Cancer Center of the University of Pennsylvania
Active, not recruiting
Distal Radius Buckle Fracture RCT
NCT04032873
Condition: Distal Radius Fracture
Interventions: Other: Monetary Cost of Immobilization Treatments; Other: Physician; Other: Study Team; Other: Before Initial Treatment Decision; Other: After Initial Treatment Decision
Sponsor: Children's Hospital of Philadelphia
Recruiting
Griffithsin-based Rectal Microbicide for PREvention of Viral ENTry (PREVENT)
NCT04032717
Condition: HIV Prevention
Interventions: Drug: Q-Griffithsin (Q-GRFT) enema; Other: Placebo enema
Sponsors: Rhonda Brand; National Institute of Allergy and Infectious Diseases (NIAID); Intrucept Biomedicine LLC
Recruiting
Breaking Down Care Process and Patient-level Barriers to Arteriovenous Access Creation Prior to Hemodialysis Initiation
NCT04032613
Conditions: Chronic Kidney Disease; Chronic Kidney Disease Requiring Chronic Dialysis
Intervention: Other: Vascular Access Navigation and Education Quality Improvement Program
Sponsors: University of North Carolina, Chapel Hill; Geisinger Clinic; Duke University; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting
Optoacoustic Images Versus Imagio® Ultrasound
NCT04030104
Condition: Breast Cancer
Interventions: Device: Reader Study - Imagio Ultrasound; Device: Reader Study Imagio Ultrasound + Optoacoustic Imaging
Sponsor: Seno Medical Instruments Inc.
Active, not recruiting
Pitocin or Oral Misoprostol for PROM IOL
NCT04028765
Condition: PROM
Interventions: Drug: Misoprostol; Drug: Oxytocin
Sponsor: University of Pennsylvania
Recruiting
Cardiovascular Effects of CART Cell Therapy
NCT04026737
Conditions: Leukemia; Lymphoma; Cardiotoxicity; Risk Factor, Cardiovascular; Immunotherapy
Intervention:
Sponsor: Abramson Cancer Center of the University of Pennsylvania
Recruiting
A Study of CART-TnMUC1 in Patients With TnMUC1-Positive Advanced Cancers
NCT04025216
Conditions: Non-Small Cell Lung Cancer; Ovarian Cancer; Fallopian Tube Cancer; Triple Negative Breast Cancer; Multiple Myeloma; Pancreatic Ductal Adenocarcinoma
Interventions: Biological: CART-TnMUC1; Drug: Cyclophosphamide; Drug: Fludarabine
Sponsor: Tmunity Therapeutics
Recruiting
Chronic Insomnia and CSF Markers of Dementia
NCT04024020
Condition: Insomnia Chronic
Intervention: Other: lumbar puncture
Sponsors: University of Pennsylvania; Merck Sharp & Dohme Corp.
Recruiting
Clinic Navigation and Home Visits to Improve Guideline-based Care and Outcomes in Low Income Minority Adults With Asthma
NCT04023422
Condition: Asthma
Interventions: Behavioral: Clinical intervention; Behavioral: Feedback
Sponsors: University of Pennsylvania; National Heart, Lung, and Blood Institute (NHLBI)
Recruiting
Risk-Guided Cardioprotection With Carvedilol in Breast Cancer Patients Treated With Doxorubicin and/or Trastuzumab
NCT04023110
Conditions: Cardiotoxicity; Risk Factor, Cardiovascular; Toxicity Due to Chemotherapy; Breast Cancer; Cardiomyopathies; Heart Failure
Intervention: Drug: Carvedilol
Sponsor: Abramson Cancer Center of the University of Pennsylvania
Recruiting
Short Course Chemo-Radiation Therapy for Patients With Newly Diagnosed Glioblastoma
NCT04019262
Condition: Glioblastoma
Interventions: Radiation: Radiation Therapy; Drug: Temozolomide Oral Product
Sponsor: John Flickinger
Not yet recruiting
Breast Milk: Influence of the Micro-transcriptome Profile on Atopy in Children and Toddlers
NCT04017520
Conditions: Atopy; Atopic Dermatitis Eczema; Wheezing; Food Allergy in Infants
Intervention:
Sponsors: Milton S. Hershey Medical Center; The Gerber Foundation
Recruiting
Decreasing Stress in Type 2 Diabetes
NCT04016415
Conditions: Stress; Diabetes Mellitus, Type 2
Interventions: Behavioral: Mindfulness Based Stress Reduction; Behavioral: Stress Management Education
Sponsors: Milton S. Hershey Medical Center; Rowan University; Penn State University; National Institutes of Health (NIH); National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Not yet recruiting
Mini Theta Burst TMS in MDD Patients
NCT04014959
Condition: Major Depressive Disorder
Intervention: Combination Product: TMS/ fMRI Stimulation
Sponsor: University of Pennsylvania
Recruiting
Taking Action: a Care for Type 2 Diabetes Intervention for Couples
NCT04014582
Condition: Type 2 Diabetes
Interventions: Behavioral: Communal Coping Intervention; Behavioral: Diabetes Education
Sponsor: Carnegie Mellon University
Recruiting
Adjuvant Treatment Determined By Pathological Response To Neoadjvuant Nivolumab
NCT04013854
Conditions: Melanoma Stage III; Melanoma
Interventions: Drug: nivolumab; Drug: Ipilimumab
Sponsor: Abramson Cancer Center of the University of Pennsylvania
Not yet recruiting
Connected Health to Decrease Opioid Use in Patients With Chronic Pain
NCT04013529
Condition: Chronic Pain
Interventions: Behavioral: Regret lottery; Behavioral: Way to Health technology enhanced care
Sponsor: University of Pennsylvania
Recruiting
Prize-linked Savings Initiatives for Promoting Better Health and Economic Outcomes in Kenya
NCT04013295
Condition: HIV/AIDS
Intervention: Other: Prize-linked savings
Sponsors: University of Pennsylvania; Impact Research & Development Organization; Innovations for Poverty Action; Bill and Melinda Gates Foundation
Completed
A Trial of Behavioral Economic Interventions Among Food Pantry Clients
NCT04011384
Condition: Food Preferences
Intervention: Behavioral: Behavioral economic intervention of online purchasing at a food pantry
Sponsors: University of Pennsylvania; Massachusetts General Hospital; University of Connecticut; National Cancer Institute (NCI)
Recruiting
Hypnosis for Bladder Pain Syndrome
NCT04010513
Conditions: Bladder Pain Syndrome; Interstitial Cystitis
Interventions: Behavioral: Hypnosis; Other: Standard of Care
Sponsor: University of Pennsylvania
Not yet recruiting
A Novel Usage of Transdermal Scopolamine in Reducing Narcotic Usage in Outpatient Hand Surgery
NCT04008264
Condition: Post Operative Pain Management
Intervention: Drug: Scopolamine Patch (Transderm V)
Sponsor: Alexander M Spiess, MD
Recruiting
Health Promoters and Organ Donation
NCT04007419
Conditions: Organ Donation; Donor Designation/Registration
Intervention: Behavioral: Health Promoters and Organ Donation
Sponsor: Temple University
Recruiting
The Value of Screening for HPR in Patients Undergoing Lower Extremity Arterial Endovascular Interventions
NCT04007055
Conditions: Peripheral Artery Disease; Clopidogrel, Poor Metabolism of; Peripheral Vascular Disease; Artery Disease; Peripheral Arterial Occlusive Disease
Interventions: Diagnostic Test: Point of care screening for HPR; Drug: Ticagrelor 90mg
Sponsor: Kyle Markel
Recruiting
Time Restricted Eating Pilot - Bariatrics
NCT04006366
Condition: Time Restricted Feeding
Intervention: Behavioral: Time restricted feeding
Sponsor: University of Pennsylvania
Enrolling by invitation
Health Education and Relationships Through Theater: An RCT of Promoting Awareness Through Live Movement and Sound for Youth With Autism Spectrum Disorder (PALMS-ASD)
NCT04005547
Conditions: Sexual Health; Education, Health
Intervention: Behavioral: Promoting Awareness through Live Movement and Sound for youth with Autism Spectrum Disorder
Sponsors: Public Health Management Corporation; Temple University
Recruiting
A Study to Evaluate Abemaciclib in Advanced Biliary Tract Carcinoma Who Failed Prior First Line Therapy
NCT04003896
Condition: Biliary Tract Carcinoma
Intervention: Drug: Abemaciclib
Sponsors: Milton S. Hershey Medical Center; Eli Lilly and Company
Not yet recruiting
The Effect of Prolonged Multimodal Analgesic Regimen on Post Hospital Discharge Opioid Use and Pain Control After Primary Total Knee Arthroplasty
NCT04003350
Condition: Osteo Arthritis Knee
Interventions: Drug: Oxycodone; Drug: Tramadol; Drug: Tylenol; Drug: Meloxicam; Drug: Gabapentin; Drug: Metaxalone; Drug: Esomeprazole 20mg
Sponsor: Rothman Institute Orthopaedics
Completed
Superficial Peroneal Nerve Neuromodulation for Non-Obstructive Urinary Retention
NCT04000763
Conditions: Urinary Retention; Urinary Bladder, Underactive
Intervention: Device: superficial peroneal nerve stimulation
Sponsors: Katherine Shapiro; Society of Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction; University of North Carolina, Chapel Hill
Not yet recruiting
Insulin Start Therapy Application With Resources and Training
NCT03999268
Condition: Diabetes Mellitus, Type 2
Interventions: Behavioral: I-START; Behavioral: Standard Insulin Administration Education
Sponsor: University of Pittsburgh
Not yet recruiting
The Impact of a Home-based Pulmonary Telerehabilitation Program in Acute Exacerbations of COPD
NCT03997513
Condition: Pulmonary Disease, Chronic Obstructive
Intervention: Behavioral: Pulmonary Telerehabilitation
Sponsor: VA Office of Research and Development
Not yet recruiting
Prevention of Unmitigated Chemotherapy-induced Emesis
NCT03996863
Conditions: Chemotherapy-induced Nausea and Vomiting; Nausea Post Chemotherapy
Interventions: Device: Otoband; Device: Placebo device
Sponsors: Otolith Labs; Drexel University College of Medicine
Not yet recruiting
Medication Adherence and Outcomes Among Patients in United States With HIV
NCT03995745
Conditions: Human Immunodeficiency Virus; Medication Adherence
Intervention: Behavioral: Medication adherence and financial incentives
Sponsors: University of Pennsylvania; Drexel University
Recruiting
Effect of rTMS on Anxiety
NCT03993509
Conditions: Anxiety; Fear; Anxiety and Fear
Intervention: Device: rTMS to the right dlPFC
Sponsor: University of Pennsylvania
Not yet recruiting
A Study of a Values-Based Intervention to Promote Weight Loss
NCT03991676
Conditions: Obesity; Weight Loss
Intervention: Behavioral: Values-Based Behavioral Treatment
Sponsor: Drexel University
Recruiting
Vessel Wall MR Imaging to Explore Sex-Differences of Intracranial Arterial Wall Changes After Suspected Stroke
NCT03990545
Conditions: Intracranial Atherosclerosis; Acute Stroke; Transient Ischemic Attack
Intervention:
Sponsor: University of Pennsylvania
Recruiting
Prospective Use of Awake Endoscopy for Inspire Activation
NCT03990298
Condition: Obstructive Sleep Apnea
Intervention: Diagnostic Test: Awake endoscopy
Sponsor: University of Pennsylvania
Enrolling by invitation
[18F]Fluciclovine in Post-treatment Glioblastoma ( Axumin )
NCT03990285
Condition: Glioma Glioblastoma Multiforme
Intervention: Drug: Axumin, Intravenous Solution
Sponsors: Seyed Ali Nabavizadeh, MD; Blue Earth Diagnostics
Recruiting
Biological Effects of Quercetin in COPD
NCT03989271
Condition: Chronic Obstructive Pulmonary Disease
Intervention: Drug: Quercetin
Sponsors: Temple University; National Institutes of Health (NIH); Quercegen Pharmaceuticals; National Center for Complementary and Integrative Health (NCCIH)
Recruiting
Improving Self-care of Heart Failure Caregivers
NCT03988621
Condition: Heart Failure
Intervention: Behavioral: ViCCY
Sponsor: University of Pennsylvania
Recruiting
Open Label Pharmaco- Magnetic Resonance Spectrography (MRS) Study of Clavulanic Acid
NCT03986762
Conditions: Cocaine Dependence, in Remission; Cocaine Abuse, in Remission; Cocaine-Related Disorders
Intervention: Drug: Clavulanic Acid
Sponsors: Temple University; National Institute on Drug Abuse (NIDA)
Recruiting
Mindfulness-based Dance/Movement Therapy for Chronic Low Back Pain
NCT03986489
Condition: Chronic Low-back Pain
Interventions: Behavioral: Mindfulness-based dance/movement therapy (M-DMT); Behavioral: Chronic pain social support group
Sponsors: Drexel University; National Center for Complementary and Integrative Health (NCCIH); Stony Brook University
Recruiting
Specialty Medical Homes to Improve Outcomes for Patients With IBD and Behavioral Health Conditions
NCT03985800
Conditions: Inflammatory Bowel Disease; Behavioral Symptoms
Interventions: Other: TEAM; Other: TECH
Sponsors: University of Pittsburgh; Mount Sinai Hospital, New York; The Cleveland Clinic; Patient-Centered Outcomes Research Institute
Recruiting
Machine-Generated Mortality Estimates and Nudges to Promote Advance Care Planning Discussion Among Cancer Patients
NCT03984773
Condition: Oncology
Intervention: Behavioral: Nudge
Sponsor: University of Pennsylvania
Enrolling by invitation
Heart Failure Self-care Mobile Application to Reduce Readmissions Trial
NCT03982017
Condition: Heart Failure
Interventions: Other: Mobile Health Technology Platform; Other: Usual care
Sponsors: University of Pittsburgh; Agency for Healthcare Research and Quality (AHRQ)
Not yet recruiting
Nurse AMIE: Addressing Metastatic Individuals Everyday
NCT03975621
Condition: Metastatic Breast Cancer
Intervention: Behavioral: Supportive Care
Sponsor: Milton S. Hershey Medical Center
Recruiting
Understanding Trauma Nightmares Using In-Home Measurement
NCT03974503
Conditions: Nightmares; Stress Disorders, Post-Traumatic; Actigraphy; Respiratory Sinus Arrhythmia; Veterans
Interventions: Behavioral: Exposure, Relaxation, and Rescripting Therapy; Behavioral: Sleep and Nightmare Management
Sponsor: VA Office of Research and Development
Not yet recruiting
Penn Microbiome Therapy for Recurrent Clostridium Difficile Infection
NCT03973697
Condition: Recurrent Clostridium Difficile Infection
Interventions: Drug: Penn Microbiome Therapy - 001; Drug: Penn Microbiome Therapy - 002; Drug: Penn Microbiome Therapy - 003
Sponsor: University of Pennsylvania
Not yet recruiting
Impact of Serious Pediatric Illness on Parent and Sibling Health
NCT03971344
Conditions: Family Members of: Newborns Extremely Premature; Family Members of: New Pediatric Oncology Patients; Family Members of: Critical Congenital Heart Defect Patients; Family Members of: Children Severe Neurological Impairment
Intervention:
Sponsors: Children's Hospital of Philadelphia; Cigna Foundation
Enrolling by invitation
The Effect of Self-Forgiveness on Self-Stigma in Addiction.
NCT03971097
Conditions: Substance Use Disorders; Opiate Dependence; Opiate Withdrawal Syndrome; Opioid-use Disorder; Alcohol Withdrawal; Alcohol Abuse; Alcohol Use Disorder; Cocaine Abuse; Cocaine Use Disorder; Cocaine Withdrawal; Benzodiazepine Abuse; Benzodiazepine Dependence; Substance Abuse; Heroin Overdoses; Heroin Withdrawal; Heroin Abuse
Interventions: Behavioral: Six Step Model of Self-Forgiveness; Behavioral: Treatment as Usual (TAU)
Sponsors: University of Pittsburgh; Indiana University of Pennsylvania
Recruiting
PMT for Severe-CDI
NCT03970200
Conditions: Severe Clostridium Difficile Infection; Severe-Complicated/Fulminant Clostridium Difficile Infection
Interventions: Drug: Penn Microbiome Therapy - 001; Drug: Penn Microbiome Therapy - 002; Drug: Penn Microbiome Therapy - 003; Drug: Antibiotics
Sponsor: University of Pennsylvania
Not yet recruiting
Abemaciclib in Patients With Oligodendroglioma
NCT03969706
Condition: Oligodendroglioma, Adult
Intervention: Drug: Abemaciclib 200 MG
Sponsor: University of Pennsylvania
Recruiting
Telehealth Intervention in Cirrhotics
NCT03969186
Conditions: Cirrhosis, Liver; Liver Diseases
Intervention: Behavioral: Intervention
Sponsor: University of Pennsylvania
Recruiting
MOVE UP Lifestyle Intervention for Caregivers
NCT03967912
Conditions: Body Weight; Healthy Diet; Physical Activity; Health Behavior; Healthy Aging
Intervention: Behavioral: MOVE UP
Sponsors: University of Pittsburgh; Centers for Disease Control and Prevention
Not yet recruiting
Assessing the Impact of myHealth Rewards Enrollment Emails
NCT03965754
Conditions: Health Promotion; Wellness Programs
Interventions: Behavioral: Social norms; Behavioral: Loss framing; Behavioral: Email reminder
Sponsor: Geisinger Clinic
Active, not recruiting
Developing an Injury Prevention Simulation Game to Better Engage Parents in Services -Home Safety Hero
NCT03965377
Condition: Parenting
Intervention: Behavioral: Home Safety Hero Computer Game
Sponsor: Penn State University
Enrolling by invitation
Priming With tDCS: Expanding the Window of Recovery in Chronic Stroke
NCT03964467
Condition: Upper Extremity Paresis
Intervention: Device: transcranial direct current stimulation
Sponsors: University of the Sciences in Philadelphia; Chapman University; Moss Rehabilitation Research Institute; Thomas Jefferson University
Recruiting
Sustainability of MOVE UP Lifestyle Intervention
NCT03963830
Conditions: Body Weight; Diet, Healthy; Physical Disability
Intervention: Behavioral: MOVE UP
Sponsors: University of Pittsburgh; Centers for Disease Control and Prevention
Recruiting
Molecular Basis of Pediatric Liver Cancer
NCT03959800
Conditions: Childhood Liver Cancer; Liver Malignant Tumors; Embryonal Sarcoma of Liver (Disorder); Hepatoblastoma; Hepatocellular Carcinoma; Rhabdoid Tumor of Liver
Intervention:
Sponsor: University of Pittsburgh
Recruiting
Cardiac Cath Lab Staff Radiation Exposure
NCT03959072
Conditions: Coronary Artery Disease; Chronic Total Occlusion of Coronary Artery; Percutaneous Coronary Intervention
Interventions: Device: Robotic CTO PCI; Procedure: Conventional (Manual) CTO PCI
Sponsor: Corindus Inc.
Not yet recruiting
Palliative Care Consultations in the Skilled Nursing Facility (SNF) Setting
NCT03958552
Conditions: Palliative Care; Advance Care Planning; Skilled Nursing Facilities
Intervention: Other: Palliative Care Consultation
Sponsor: University of Pennsylvania
Enrolling by invitation
A Study Based on Medical Records That Looks at the Characteristics of Idiopathic Pulmonary Fibrosis Patients Grouped by the Type of Medication They Are Taking
NCT03958071
Condition: Idiopathic Pulmonary Fibrosis
Interventions: Drug: Nintedanib; Drug: Pirfenidone; Other: Untreated Cohort
Sponsor: Boehringer Ingelheim
Completed
Hyperthermia and Olaparib in Treating Breast Cancer Patients With Chest Wall Recurrences
NCT03955640
Conditions: Metastatic Malignant Neoplasm in the Chest Wall; Recurrent Breast Carcinoma
Interventions: Drug: Olaparib; Procedure: Hyperthermia Treatment; Other: Questionnaire Administration; Other: Quality-of-Life Assessment
Sponsors: Thomas Jefferson University; AstraZeneca
Recruiting
POC SPLA2-IIA as a Biomarker for Sepsis and Septic Shock
NCT03953404
Condition: Sepsis
Intervention: Diagnostic Test: SPLA2-IIA
Sponsor: St. Luke's Hospital, Pennsylvania
Recruiting
HeartPhone Cancer Survivors Trial 2019
NCT03953326
Conditions: Breast Cancer; Leukemia; Lymphoma
Interventions: Behavioral: HeartPhone app; Drug: Acetylcholine; Drug: Sodium Nitroprusside; Drug: L-Arginine, N2-((4-Methylphenyl)Sulfonyl)-, Methyl Ester
Sponsor: Penn State University
Recruiting
Reducing Sedentary Behavior to Improve Sleep: an Ancillary Study to the RESET BP Clinical Trial
NCT03946228
Conditions: Sleep; Obstructive Sleep Apnea; Insomnia
Intervention: Behavioral: Behavioral Intervention
Sponsors: University of Pittsburgh; National Heart, Lung, and Blood Institute (NHLBI)
Enrolling by invitation
Healthy Mom Zone: A Gestational Weight Gain Management Intervention
NCT03945266
Conditions: Overweight and Obesity; Physical Activity; Weight Change, Body; Eating Behavior
Interventions: Behavioral: Intervention group; Behavioral: Control group
Sponsors: Penn State University; National Heart, Lung, and Blood Institute (NHLBI); Arizona State University
Completed
Virtual Reality-enhanced Exercise and Education in Cardiac Rehabilitation
NCT03945201
Conditions: Adherence, Patient; Motivation; Satisfaction
Interventions: Other: Virtual walking trails; Other: Standard of care
Sponsor: Thomas Jefferson University
Completed
Genetics and Shared Decision Making in Improving Care for Patients With Stage IVA-C Non-small Cell Lung Cancer
NCT03944265
Conditions: Activating ALK Gene Mutation Negative; Activating EGFR Gene Mutation Negative; Activating ROS1 Gene Mutation Negative; Health Care Provider; Lung Non-Small Cell Carcinoma; Stage IV Lung Cancer AJCC v8; Stage IVA Lung Cancer AJCC v8; Stage IVB Lung Cancer AJCC v8
Interventions: Other: Counseling; Other: Questionnaire Administration; Other: Medical Chart Review
Sponsor: Thomas Jefferson University
Recruiting
Development and Initial Tests of Reward Re-Training: A Novel Treatment For Reward Dysfunction
NCT03942874
Conditions: Binge Eating; Binge-Eating Disorder; Bulimia Nervosa
Intervention: Behavioral: Group Reward Retraining
Sponsor: Drexel University
Enrolling by invitation
Using Digital Health, Financial Incentives, and Community Health Worker Support to Change Health Behavior
NCT03939793
Condition: Diabetes Mellitus
Interventions: Behavioral: IMPaCT Community Health Worker; Behavioral: Digital health monitoring with financial incentives; Other: Usual Care
Sponsors: University of Pennsylvania; The Commonwealth Fund
Recruiting
NGS for Non-unions
NCT03937310
Condition: Nonunion of Fracture
Intervention: Diagnostic Test: Next-generation sequencing of swabs collected during surgery
Sponsor: Rothman Institute Orthopaedics
Enrolling by invitation
Study of Humidified Air to Improve Mucociliary Clearance (MCC) in COPD
NCT03935932
Condition: COPD
Intervention: Device: nasal delivery of heated and humidified air
Sponsors: Frank C Sciurba; Fisher and Paykel Healthcare
Recruiting
Adoptive Transfer of Tumor Infiltrating Lymphocytes for Advanced Solid Cancers
NCT03935893
Conditions: Gastric Cancer; Colorectal Cancer; Pancreatic Cancer; Sarcoma; Mesothelioma; Neuroendocrine Tumors; Squamous Cell Cancer; Merkel Cell Carcinoma; Mismatch Repair Deficiency; Microsatellite Instability
Interventions: Biological: Tumor Infiltrating Lymphocytes (TIL); Drug: Fludarabine + Cyclophosphamide combination
Sponsor: Udai Kammula
Recruiting
Evaluating an Alternative Clinical Genetics Cancer Care Deliver Model
NCT03934606
Conditions: Pancreas Cancer; Prostate Cancer; Hereditary Cancer; Genetic Predisposition to Disease
Intervention: Behavioral: Genetic testing for hereditary predisposition
Sponsor: University of Pennsylvania
Recruiting
A Study for the Assessment of the Benefits of a Novel Mesh Nebulizer in the Treatment of Patients With Stable COPD
NCT03933462
Condition: COPD
Interventions: Device: InnoSpire Go; Device: Jet Nebulizer
Sponsor: Philips Respironics
Active, not recruiting
Circulating miRNA in Primary Hyperparathyroidism
NCT03931109
Conditions: Primary Hyperparathyroidism; Osteoporosis, Postmenopausal
Intervention:
Sponsor: University of Pennsylvania
Recruiting
Coping Together After Breast Cancer
NCT03930797
Condition: Breast Cancer
Interventions: Behavioral: Intimacy Enhancement; Behavioral: Living Healthy Together
Sponsors: Fox Chase Cancer Center; National Cancer Institute (NCI)
Recruiting
Proactive Outreach and Shared Decision Making in Improving Lung Cancer Screening Rates in Primary Care Patients
NCT03929926
Condition: Lung Cancer
Interventions: Other: Best Practice; Behavioral: Cancer Educational Materials; Other: Behavioral, Psychological or Informational Intervention; Other: Counseling
Sponsor: Thomas Jefferson University
Recruiting
Contrast Enhanced Mammography in Diagnosing Patients With Suspicious Breast Findings
NCT03929783
Condition: Breast Neoplasms
Intervention: Procedure: Contrast Enhanced Digital Mammography
Sponsor: Thomas Jefferson University
Not yet recruiting
Management Of Pain After Cesarean Trial
NCT03929640
Conditions: Pain, Postoperative; Opioid Use
Interventions: Drug: Acetaminophen; Drug: Placebo; Drug: Ibuprofen
Sponsor: Milton S. Hershey Medical Center
Recruiting
Shifting Perspectives: Enhancing Outcomes in Anorexia Nervosa With CRT
NCT03928028
Condition: Anorexia Nervosa
Interventions: Behavioral: Cognitive Remediation Therapy; Behavioral: Family Based Treatment
Sponsor: Children's Hospital of Philadelphia
Recruiting
First - In - Man Study to Assess the Safety and Feasibility of The Bashir™ Endovascular Catheter for the Treatment of Acute Pulmonary Embolism
NCT03927508
Condition: Pulmonary Embolism
Interventions: Drug: r-tPA; Device: The Bashir™ Endovascular Catheter
Sponsor: Thrombolex, Inc.
Recruiting
Variations in Palatability and Portion Size of Vegetables on Meal Intake of Preschool Children
NCT03926065
Condition: Feeding Behavior
Interventions: Other: Plain Vegetables Served in 100% Portion Size; Other: Plain Vegetables Served in 200% Portion Size; Other: Enhanced Vegetables Served in 100% Portion Size; Other: Enhanced Vegetables Served in 200% Portion Size
Sponsors: Penn State University; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting
Evaluation of TXA Prior to Surgery in the Geriatric Hip Fracture Population
NCT03923959
Condition: Hip Fractures
Interventions: Drug: Tranexamic Acid Injectable Solution; Other: Placebo
Sponsor: Lancaster General Hospital
Recruiting
Fixed Inclination Humeral Cut
NCT03922763
Condition: Shoulder Osteoarthritis
Interventions: Procedure: Anatomical cut; Procedure: Cutting guide
Sponsor: Rothman Institute Orthopaedics
Enrolling by invitation
Telehealth Following Orthopaedic Procedures
NCT03922737
Condition: Post-Op Complication
Interventions: Procedure: In-person office visit; Procedure: Teleheath visit
Sponsor: Rothman Institute Orthopaedics
Enrolling by invitation
JAK Inhibitor Treatment in AGS
NCT03921554
Condition: Aicardi Goutieres Syndrome
Intervention: Drug: Baricitinib
Sponsors: Adeline Vanderver, MD; Eli Lilly and Company
Recruiting
Augmented Reality Enhanced Surgery: Use of Holographic Technology in Cranial and Spinal Surgery
NCT03921385
Condition: Surgery
Intervention:
Sponsor: University of Pennsylvania
Active, not recruiting
Study of Subretinally Injected SAR439483 Administered in Patients With Leber Congenital Amaurosis Caused by Biallelic Mutations in GUCY2D
NCT03920007
Condition: Leber's Congenital Amaurosis
Interventions: Drug: SAR439483; Drug: SAR439483 Diluent Solution; Drug: Prednisone; Drug: Triamcinalone Acetonide; Drug: 1% Prednisolone; Drug: Trimethoprim/polymyxin B
Sponsor: Sanofi
Recruiting
TEMPO Study: Trimethoprim-Sulfamethoxazole in Granulomatosis With Polyangiitis
NCT03919435
Conditions: Granulomatosis With Polyangiitis; Wegener Granulomatosis
Intervention: Drug: Trimethoprim Sulfamethoxazole
Sponsor: University of Pennsylvania
Recruiting
The Effects of Guarding on the Outcomes of the Six Minute Walk Test
NCT03916952
Conditions: Functional Capacity; Physical Activity; Rehabilitation
Intervention: Diagnostic Test: Six Minute Walk Test
Sponsor: Concordia University, St. Paul
Completed
Integrated Approaches for Identifying Molecular Targets in Liver Disease
NCT03915002
Conditions: Alcoholic Liver Disease; Non-Alcoholic Fatty Liver Disease; Steatohepatitis, Nonalcoholic; Steatohepatitis
Intervention:
Sponsor: University of Pittsburgh
Recruiting
Virtual Reality in Plastic Surgery: Pain Control and Augmented Satisfaction
NCT03914937
Conditions: Pain; Anxiety
Interventions: Other: Virtual reality; Other: Music
Sponsor: The Guthrie Clinic
Recruiting
Facilitating Optimal Routines in Aging
NCT03913637
Condition: Strategy Training
Interventions: Behavioral: Strategy Training; Other: Enhanced Usual Care
Sponsors: University of Pittsburgh; National Institutes of Health (NIH); National Institute on Aging (NIA)
Recruiting
Neuromotor Prosthetic to Treat Stroke-Related Paresis
NCT03913286
Conditions: Stroke, Complication; Stroke; Stroke Sequelae; Hemiparesis; Arm Paralysis
Intervention: Device: Cortimo
Sponsor: Thomas Jefferson University
Recruiting
Comparative Effectiveness of Social Physical Play and Traditional Exercise Programming
NCT03913078
Conditions: Group Fitness (Traditional); Group Fitness (Game Play-based)
Interventions: Behavioral: Group Fitness; Behavioral: PlayFit
Sponsors: Milton S. Hershey Medical Center; National Institutes of Health (NIH)
Recruiting
Opioid Taper Study
NCT03912298
Condition: Chronic Pain
Intervention: Other: Opioid Taper Pain perception
Sponsors: University of Pennsylvania; National Institute on Drug Abuse (NIDA); National Institutes of Health (NIH)
Recruiting
Whole Exome Sequencing and Whole Genome Sequencing for Non-immune Fetal/Neonatal Hydrops
NCT03911531
Conditions: Non-immune Fetal Hydrops; Non-Immune Hydrops in Neonate; Genetic Disorders
Interventions: Diagnostic Test: Whole Exome Sequencing; Diagnostic Test: Whole Genome Sequencing
Sponsor: Thomas Jefferson University
Recruiting
Evaluation of SmartSleep Technology for Improving the Efficiency and Restorative Quality of Sleep in Healthy Adults
NCT03911154
Condition: Sleep
Intervention: Device: Philips SmartSleep Technology
Sponsors: University of Pennsylvania; National Aeronautics and Space Administration (NASA); Philips Healthcare; University of Wisconsin, Madison
Recruiting
Behavioral Economic Approaches to Increase Physical Activity Among Patients With Elevated Risk for Cardiovascular Disease
NCT03911141
Condition: Atherosclerotic Cardiovascular Disease
Interventions: Behavioral: Gamification; Behavioral: Financial
Sponsor: University of Pennsylvania
Recruiting
A Collection of Case Studies in Infants With UCD to Evaluate Infant Growth and the Safety of a New Medical Food for UCD
NCT03911089
Conditions: Urea Cycle Disorder; Inborn Errors of Metabolism
Intervention: Other: UCD Anamix Infant
Sponsor: Nutricia Research
Active, not recruiting
Positive Parenting Program in Foster Care
NCT03910491
Conditions: Child Behavior Problem; Child Behavior Disorders; Parenting
Intervention: Behavioral: PriCARE
Sponsors: Children's Hospital of Philadelphia; Ray E. Helfer Society
Recruiting
Wheelchair Maintenance Training Program
NCT03909061
Condition: Remote Maintenance Training Program
Intervention: Behavioral: Wheelchair Maintenance Training
Sponsors: University of Pittsburgh; Department of Health and Human Services
Recruiting
Rapid Initiation of Drug Treatment Engagement
NCT03908437
Conditions: Opioid-use Disorder; Overdose
Intervention: Drug: buprenorphine/naloxone
Sponsors: University of Pennsylvania; Prevention Point Philadelphia; Public Health Management Corporation; Philadelphia Department of Public Health
Recruiting
Random Assignment of Intervention Messages for Developing Personalized Decision Rules to Promote Physical Activity
NCT03907683
Condition: Cardiovascular Risk Factor
Intervention: Behavioral: Short Message with Text and Optional Image
Sponsor: Penn State University
Recruiting
The Tailored Adherence Incentives for Childhood Asthma Medications (TAICAM) Trial
NCT03907410
Conditions: Medication Adherence; Asthma in Children
Interventions: Other: Nominal Financial Incentives; Other: Daily Adherence Reminders/Adherence Performance Feedback
Sponsors: Children's Hospital of Philadelphia; National Institutes of Health (NIH); National Heart, Lung, and Blood Institute (NHLBI)
Recruiting
SIS Evaluation of the MRI Defined Subthalamic Nucleus*
NCT03907319
Condition: Deep Brain Stimulation
Intervention: Device: SIS System
Sponsor: Surgical Information Sciences Inc.
Enrolling by invitation
Establishing the Effect of Flavor on the Addictive Potential of Electronic Cigarettes
NCT03905928
Condition: Tobacco Dependence
Interventions: Other: Nicotine Containing ECIG with tobacco flavor; Other: Nicotine Containing ECIG with Strawberry Vanilla Flavor; Other: Placebo ECIG with Tobacco Flavor; Other: Placebo ECIG with Strawberry Vanilla Flavor
Sponsors: Milton S. Hershey Medical Center; National Institutes of Health (NIH)
Recruiting
A Study of Abemaciclib in Combination With Sunitinib in Metastatic Renal Cell Carcinoma
NCT03905889
Condition: Renal Cell Carcinoma Metastatic
Interventions: Drug: Abemaciclib; Drug: Sunitinib
Sponsors: Milton S. Hershey Medical Center; Eli Lilly and Company
Suspended
Exercise Therapy in Radiation Therapy
NCT03905356
Condition: Metastatic Cancer
Intervention: Behavioral: Exercise Therapy
Sponsor: Milton S. Hershey Medical Center
Not yet recruiting
miRNA and Myokines in Patients With PAH
NCT03905083
Condition: Pulmonary Arterial Hypertension
Intervention: Other: Exercise Rehab
Sponsor: University of Pittsburgh
Recruiting
ASSIST: Treatment for Childhood Apraxia of Speech
NCT03903120
Condition: Childhood Apraxia of Speech
Intervention: Behavioral: ASSIST
Sponsor: Temple University
Recruiting
Study of ST266 Given by Intranasal Delivery in Subjects With Ocular Hypertension
NCT03901781
Condition: Ocular Hypertension
Intervention: Combination Product: ST266 via Intranasal Delivery
Sponsor: Noveome Biotherapeutics, formerly Stemnion
Recruiting
Evaluation of Flortaucipir PET Signal and Cognitive Change in Early Alzheimer's Disease
NCT03901105
Condition: Alzheimer Disease
Intervention: Drug: flortaucipir F18
Sponsor: Avid Radiopharmaceuticals
Completed
A Reader Study to Assess Accuracy and Reliability of Flortaucipir F 18 PET Scan Interpretation
NCT03901092
Condition: Alzheimer Disease
Intervention: Drug: flortaucipir F 18
Sponsor: Avid Radiopharmaceuticals
Completed
Effects of Heating on Exercise Pressor Reflex in Peripheral Artery Disease: Exercise Ability
NCT03900832
Condition: PAD
Interventions: Other: Without Heating; Other: Warm Bath; Other: Neutral Bath; Other: Heating Suit; Other: Lower limb warm water immersion; Other: Gardner walking protocol
Sponsor: Milton S. Hershey Medical Center
Recruiting
Plan and Pledge, HIV Self-testing in South Africa
NCT03898557
Condition: Human Immunodeficiency Virus
Interventions: Behavioral: Provision of HIV self-test with Commitment and planning prompts; Behavioral: Provision of HIV self-test
Sponsors: University of Pennsylvania; Wits Reproductive Health and HIV Institute
Active, not recruiting
Pneumatic Technology for Powered Mobility Devices
NCT03898362
Condition: Disability
Interventions: Other: pneumatically powered wheelchair or scooter; Device: battery powered wheelchair or scooter
Sponsor: VA Office of Research and Development
Not yet recruiting
Perioperative Glucocorticoid Administration in the Treatment of Adult Distal Radius Fractures
NCT03898154
Condition: Distal Radius Fracture
Interventions: Drug: Dexamethasone; Drug: Methylprednisolone
Sponsor: C. Liam Dwyer
Recruiting
The Effect of Tranexamic Acid on Blood Coagulation in Total Hip Arthroplasty Surgery
NCT03897621
Conditions: Coagulation; Intravascular; Rotational Thromboelastometry; Fibrinolysis; Hemorrhage; Tranexamic Acid; Total Hip Arthroplasty
Interventions: Drug: Tranexamic Acid; Drug: Placebo
Sponsor: Thomas Jefferson University
Recruiting
Ketamine for Refractory Chronic Migraine: a Pilot Study
NCT03896256
Condition: Migraine Headache With Intractable Migraine
Intervention: Drug: ketamine infusion
Sponsor: Thomas Jefferson University
Enrolling by invitation

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