Join Clinical Trials in Pennsylvania

Assessing Visual Processing in High Anxiety
NCT04187326
Condition: Anxiety
Intervention: Behavioral: Facial Microexpression Training
Sponsors: University of Pittsburgh; National Institute of Mental Health (NIMH)
Not yet recruiting
Association Between Light Spectrum and Survival After Cataract Surgery
NCT04187157
Conditions: Cataract; Age-related Cataract; Circadian Rhythm Disorders; Glaucoma; Age Related Macular Degeneration
Interventions: Device: Blue-light filtering intraocular lens; Device: Conventional intraocular lens
Sponsor: University of Pittsburgh
Completed
Epigenetic Effects on Traumatic Brain Injury Recovery
NCT04186429
Conditions: Traumatic Brain Injury; Orthopedic Injury
Intervention:
Sponsors: University of Pittsburgh; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting
Autism Spectrum Ambassador Program (ASAP) in the ED
NCT04186364
Condition: Autism Spectrum Disorder
Intervention: Behavioral: Assigned Ambassador
Sponsor: Milton S. Hershey Medical Center
Not yet recruiting
Efficacy of an Intervention to Teach Zippering: A Two-Group Control Study
NCT04185324
Condition: Typical Preschoolers Who Can Not Zipper
Interventions: Behavioral: Standard zippering vest; Behavioral: Modified zippering vest
Sponsor: Salus University
Active, not recruiting
17-OHPC in Pregnancy: IM vs SC Routes
NCT04183452
Condition: Preterm Birth
Interventions: Drug: 17-Hydroxyprogesterone Caproate 250 mg IM Dose; Drug: 17-Hydroxyprogesterone Caproate 275 mg SC Dose
Sponsors: Steve N. Caritis, MD; AMAG Pharmaceuticals, Inc.
Not yet recruiting
Transbronchial Biopsy Assisted by Robot Guidance in the Evaluation of Tumors of the Lung
NCT04182815
Conditions: Pulmonary Nodule; Lung Cancer
Intervention: Device: Robotic assisted bronchoscopy
Sponsor: Auris Health, Inc.
Not yet recruiting
Effects of Esmolol Infusion on Hemodynamic Responses to Isometric Handgrip
NCT04181606
Conditions: Peripheral Arterial Disease; Aging
Interventions: Drug: Esmolol Hydrochloride or Saline; Other: Handgrip during infusion
Sponsor: David N. Proctor, PhD
Not yet recruiting
Using Data-Driven Implementation Strategies to Improve the Quality of Cirrhosis Care
NCT04178096
Condition: Cirrhosis, Liver
Intervention: Other: Quality Improvement Intervention
Sponsors: VA Office of Research and Development; VA Pittsburgh Healthcare System; VA Quality Enhancement Research Intiative
Enrolling by invitation
Rigosertib in Patients With Recessive Dystrophic Epidermolysis Bullosa Associated SCC
NCT04177498
Condition: Recessive Dystrophic Epidermolysis Bullosa
Interventions: Drug: Rigosertib Sodium; Other: Quality-of-Life Assessment
Sponsors: Thomas Jefferson University; Onconova Therapeutics, Inc.
Not yet recruiting
Balancing Method for Pain Related to Advanced Cancer
NCT04176575
Conditions: Pain, Cancer; Metastatic Cancer; Invasive Cancer
Intervention: Other: Acupuncture
Sponsor: University of Pittsburgh
Not yet recruiting
NeuroSeq: A Prospective Trial to Evaluate the Diagnostic Yield of Whole Genome Sequencing (WGS) in Adult Neurology
NCT04170985
Conditions: Neurologic Deficits; Neurologic Disorder; Neurologic Abnormalities
Intervention: Other: clinical Whole Genome Sequencing
Sponsor: Illumina, Inc.
Recruiting
Acceptability and Efficacy of the Zemedy App for IBS
NCT04170686
Condition: Irritable Bowel Syndrome
Intervention: Behavioral: Zemedy App for IBS
Sponsors: University of Pennsylvania; Bold Health
Recruiting
Interpolated Flap Study
NCT04164550
Conditions: Skin Cancer, Non-Melanoma; Skin Cancer Melanoma; Mohs Micrographic Surgery
Intervention:
Sponsors: University of Pennsylvania; Oregon Health and Science University; Stanford University; University of Minnesota; University of Missouri-Columbia; University of Vermont; University of Nebraska
Recruiting
NIH R01 Friend to Friend With Coaching
NCT04164472
Condition: Aggression
Intervention: Behavioral: Friend to Friend (F2F) with Coaching
Sponsors: Children's Hospital of Philadelphia; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Enrolling by invitation
Targeted Intervention for Insufficient Sleep Among Typically-Developing Adolescents
NCT04163003
Condition: Sleep Disturbance
Interventions: Behavioral: Targeted Approaches for Promoting Adolescent Sleep (TAPAS); Behavioral: Sleep Monitoring Only
Sponsors: University of Pittsburgh; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting
Prevention and Treatment of Laryngospasm and Hypoxemia Based on Risk Factors in Adult Outpatients Undergoing EGD
NCT04159116
Conditions: Laryngospasm; Hypoxemia
Intervention: Other: Prophylactic suctioning when clinically indicated
Sponsor: Envision Healthcare Scientific Intelligence, Inc.
Enrolling by invitation
Evaluation of the Length of Treatment With PD-1/PD-L1 Inhibitors in Patients With Advanced Solid Tumors
NCT04157985
Conditions: Advanced Solid Tumors; NSCLC; Bladder Cancer; HNSCC; Renal Cancer; Melanoma; Anal Cancer; Colorectal Cancer; Cholangiocarcinoma; Gastric Cancer; Hepatocellular Carcinoma
Interventions: Drug: Continue PD-1/PD-L1 Inhibitors treatment; Other: Discontinue PD-1/PD-L1-1 inhibitor
Sponsor: Antoinette J Wozniak
Recruiting
The Music, Sleep and Dementia Study
NCT04157244
Conditions: Dementia; Alzheimer Disease; Circadian Rhythm Disorders; Circadian Rhythm Sleep Disorder; Insomnia; Hypersomnia; Cognitive Impairment; Cognitive Decline; Mild Cognitive Impairment; Frontotemporal Dementia; Neurocognitive Disorders; Vascular Dementia; Sleep Disorder; Memory Impairment
Intervention: Behavioral: Tailored music listening intervention
Sponsor: University of Pennsylvania
Recruiting
RHD Genotype Matching for Anti-D
NCT04156906
Conditions: Sickle Cell Disease; Anti-D Antibodies
Intervention: Biological: D+ RH genotype matched red cell units for transfusion
Sponsors: Children's Hospital of Philadelphia; New York Blood Center
Not yet recruiting
RH Genotype Matched RBC Transfusions
NCT04156893
Condition: Sickle Cells Disease
Intervention: Biological: Red cell units that are genotype matched at the RHD and RHCE loci
Sponsors: Children's Hospital of Philadelphia; New York Blood Center
Not yet recruiting
Dysbiosis Impact on Lung Disease in HIV
NCT04155684
Conditions: HIV Infections; COPD; Microbiome
Intervention:
Sponsors: University of Pittsburgh; National Heart, Lung, and Blood Institute (NHLBI)
Recruiting
Ketamine + Cognitive Training for Suicidality in the Medical Setting
NCT04154150
Condition: Suicide, Attempted
Interventions: Drug: Intravenous ketamine; Behavioral: Cognitive training; Behavioral: Sham Training
Sponsor: Rebecca Price
Not yet recruiting
POCUS Analysis of the Gastric Emptying Time of Orange Juice With and Without Pulp
NCT04146233
Conditions: Preoperative Period; Anesthesia
Intervention: Other: Point of care gastric ultrasound
Sponsor: Thomas Jefferson University
Recruiting
Nurtured in Nature
NCT04146025
Conditions: Postpartum Depression; Pregnancy Related; Environmental Exposure
Intervention: Behavioral: Nature Coach Intervention
Sponsor: University of Pennsylvania
Recruiting
Promoting Activity and Cognitive Enrichment in Schizophrenia (PACES)
NCT04143126
Condition: Schizophrenia
Interventions: Behavioral: Cognitive Enhancement Therapy; Behavioral: Enriched Supportive Therapy
Sponsors: University of Pittsburgh; National Institute of Mental Health (NIMH)
Recruiting
PD-1 Inhibitor Dostarlimab (TSR-042) vs. Combination of Tim-3 Inhibitor TSR-022 and PD-1 Inhibitor Dostarlimab (TSR-042)
NCT04139902
Conditions: Melanoma Stage III; Melanoma Stage IV
Interventions: Drug: Dostarlimab (TSR-042) (singly); Drug: Dostarlimab (TSR-042) and TSR-022 (combination)
Sponsors: Diwakar Davar; Tesaro, Inc.
Not yet recruiting
Postoperative Virtual Clinical Encounters
NCT04138810
Condition: Pelvic Organ Prolapse
Interventions: Other: VCE; Other: Survey
Sponsor: University of Pennsylvania
Completed
Opioid Counseling Following Orthopaedic Surgery
NCT04138264
Condition: Orthopedic Disorder
Intervention: Other: Preoperative opioid counseling
Sponsor: Rothman Institute Orthopaedics
Completed
The Role of Disc Nutrition in the Etiology and Clinical Treatment of Disc Degeneration
NCT04134910
Conditions: Back Pain; Intervertebral Disc Degeneration
Intervention: Procedure: Physical Therapy
Sponsor: VA Office of Research and Development
Not yet recruiting
Patient Satisfaction in Post-LASIK Patients With Presbyopia-Correcting IOLs vs. Post-Lasik Patients With Monofocal IOLs
NCT04134507
Condition: Patient Satisfaction
Intervention:
Sponsor: Bucci Laser Vision Institute
Enrolling by invitation
MRI Effects of Pegvorhyaluronidase Alfa (PEGPH20) in Pancreatic Ductal Adenocarcinoma
NCT04134468
Condition: Pancreatic Ductal Adenocarcinoma
Interventions: Drug: Pegvorhyaluronidase alfa; Drug: Abraxane; Drug: Gemcitabine
Sponsors: Abramson Cancer Center of the University of Pennsylvania; Halozyme Therapeutics
Not yet recruiting
Investigating the Experience of Living With Down Syndrome and Obstructive Sleep Apnea Syndrome (Stage 2)
NCT04132999
Conditions: Down Syndrome; Obstructive Sleep Apnea
Interventions: Behavioral: Family-informed intervention; Behavioral: Standard Clinical Care
Sponsors: Children's Hospital of Philadelphia; National Institutes of Health (NIH); National Heart, Lung, and Blood Institute (NHLBI); Children's Hospital Medical Center, Cincinnati; University of Pennsylvania
Not yet recruiting
Trial to Compare eConsent With Standard Consent Among Prospective Biobank Participants
NCT04131062
Condition: Lynch Syndrome
Intervention: Behavioral: Electronic Consent (iPad)
Sponsors: Geisinger Clinic; National Cancer Institute (NCI)
Not yet recruiting
4Kscore Using Serum Stored Uncentrifuged
NCT04130776
Condition: Prostate Cancer
Intervention: Diagnostic Test: Measurement of four prostate-specific kallikreins for the 4Kscore Test when serum stored uncentrifuged
Sponsor: OPKO Health, Inc.
Completed
New Foods Take Time, a Curriculum Designed to Promote Tasting and Liking of Fruits and Vegetables
NCT04129372
Condition: Eating Behavior
Intervention: Behavioral: New Foods Take Time
Sponsor: Penn State University
Enrolling by invitation
Improvement in Endothelial Dysfunction After Initiation of Anti-arrhythmic Therapy in Atrial Fibrillation Patients
NCT04128878
Condition: Atrial Fibrillation
Interventions: Drug: Sotalol; Drug: Dofetilide
Sponsor: University of Pittsburgh
Recruiting
Evaluating a Mindful Eating Curriculum, "Savor the Flavor"
NCT04127812
Condition: Eating Behavior
Intervention: Behavioral: Savor the Flavor
Sponsor: Penn State University
Enrolling by invitation
Using Continuous Glucose Monitoring to Detect and Intervene on Maintenance Factors for Trans-diagnostic Binge Eating Pathology
NCT04126694
Conditions: Bulimia Nervosa; Binge Eating
Intervention: Behavioral: CBT with smartphone application SenseSupport
Sponsor: Drexel University
Not yet recruiting
Oral CXA-10 in Pulmonary Arterial Hypertension
NCT04125745
Condition: Pulmonary Arterial Hypertension
Intervention: Drug: CXA-10
Sponsors: Gladwin, Mark, MD; National Heart, Lung, and Blood Institute (NHLBI); Complexa, Inc.
Recruiting
Investigating the Experience of Living With Down Syndrome and Obstructive Sleep Apnea Syndrome (Stage 1)
NCT04124471
Conditions: Down Syndrome; Obstructive Sleep Apnea
Intervention: Behavioral: Open-ended semi-structured interviews
Sponsors: Children's Hospital of Philadelphia; National Institutes of Health (NIH); National Heart, Lung, and Blood Institute (NHLBI); University of Pennsylvania; Children's Hospital Medical Center, Cincinnati
Recruiting
Pharmacist-led Transitions of Care in the Outpatient Oncology Infusion Center for Patients With Solid Tumor
NCT04122118
Condition: Malignant Solid Neoplasm
Interventions: Other: Medical Chart Review; Other: Educational Intervention; Other: Survey Administration
Sponsor: Thomas Jefferson University
Recruiting
Ocular Inflammation in Cataract Patients and Response to Treatment With Xiidra
NCT04120987
Condition: Dry Eye
Intervention: Drug: Lifitegrast 5% Ophthalmic Solution
Sponsor: Bucci Laser Vision Institute
Enrolling by invitation
Reducing Adolescent Pregnancy
NCT04120376
Conditions: Pregnancy in Adolescence; Counseling; Contraception Behavior
Intervention: Behavioral: Contraception Counseling
Sponsors: Children's Hospital of Philadelphia; Children's Mercy Hospital Kansas City
Recruiting
Randomized Clinical Trial to Increase Physical Activity After a a Hypertensive Pregnancy
NCT04119232
Conditions: Hypertension in Pregnancy; Preeclampsia; Gestational Hypertension
Intervention: Behavioral: Social incentives-based program
Sponsor: University of Pennsylvania
Recruiting
Evaluating the Efficacy of Pediatric Lipid Screening Alerts
NCT04118348
Conditions: Hypercholesterolemia; Hypercholesterolemia, Familial; Hypercholesteremia in Children; Hyperlipidemia in Children
Interventions: Behavioral: Best Practice Alert; Behavioral: Health Maintenance Topic
Sponsor: Geisinger Clinic
Not yet recruiting
Mohs Micrographic Surgery and Reconstruction in the Optum Insurance Claims Database
NCT04117373
Conditions: Skin Cancer; Mohs Micrographic Surgery; Interpolated Flap Repair
Intervention:
Sponsor: University of Pennsylvania
Active, not recruiting
Evaluation of 18F-fluciclovine (FACBC) PET/MR Uptake in Participants With Glioma
NCT04114370
Condition: Glioma
Intervention: Drug: 18F-fluciclovine
Sponsors: James Mountz; Blue Earth Diagnostics
Not yet recruiting
Acceptance and Commitment Therapy vs. Supportive Psychotherapy With Cystic Fibrosis Patients
NCT04114227
Condition: Cystic Fibrosis
Interventions: Behavioral: Acceptance and Commitment Therapy adapted for Cystic Fibrosis (ACT with CF); Behavioral: Supportive Psychotherapy (Treatment as Usual Control)
Sponsor: Drexel University
Recruiting
Anti-PD-1 mAb Plus Metabolic Modulator in Solid Tumor Malignancies
NCT04114136
Conditions: Melanoma; Renal Cell Carcinoma; NSCLC; Hepatocellular Carcinoma; Urothelial Cancer; Gastric Adenocarcinoma; HNSCC; Esophageal Adenocarcinoma; Microsatellite Instability-High Solid Malignant Tumor
Interventions: Drug: Nivolumab or Pembrolizumab (dependent upon approved indication); Drug: Metformin; Drug: Rosiglitazone
Sponsor: Dan Zandberg
Not yet recruiting
Phase 2A Study of Ad5.F35-hGCC-PADRE in Gastrointestinal Malignancies
NCT04111172
Conditions: Pancreatic Ductal Adenocarcinoma; Colorectal Adenocarcinoma; Gastric Adenocarcinoma; Esophageal Adenocarcinoma
Intervention: Biological: Ad5.F35-hGCC-PADRE
Sponsor: Thomas Jefferson University
Not yet recruiting
Enhanced Recovery After Surgery in Kidney Transplant Donors
NCT04110080
Conditions: Opioid Use; Kidney Diseases; Pain, Postoperative; Postoperative Complications; Postoperative Nausea and Vomiting
Interventions: Procedure: multimodal pain management; Other: goal directed fluid management; Other: preoperative carbohydrate loading; Procedure: Donor nephrectomy; Procedure: regional anesthesia
Sponsor: Thomas Jefferson University
Recruiting
School Adolescent Mood Project: Efficacy of Counselor-Implemented IPT-AST
NCT04109716
Condition: Depressive Symptoms
Interventions: Behavioral: Interpersonal Psychotherapy - Adolescent Skills Training; Behavioral: Services as usual
Sponsors: Children's Hospital of Philadelphia; Institute of Education Sciences
Recruiting
Sleep in Pediatric HSCT
NCT04106089
Conditions: Sleep; Stem Cell Transplant Complications
Intervention: Behavioral: Extended time between vitals check
Sponsors: Children's Hospital of Philadelphia; Rutgers University
Recruiting
Adolescent Attention to Emotion Study
NCT04105868
Condition: Depression
Intervention: Other: Neurofeedback
Sponsors: University of Pittsburgh; National Institute of Mental Health (NIMH)
Recruiting
Molecular Imaging of the Underlying Mechanism of Cardiotoxicity in Patients With Light Chain Amyloidosis Using PET/CT
NCT04105634
Condition: Cardiac Amyloidosis
Interventions: Drug: FNOS; Drug: Florbetaben
Sponsor: University of Pennsylvania
Recruiting
Tracheostomy Change
NCT04105387
Condition: Tracheostomy
Intervention: Procedure: Early Tracheostomy Change
Sponsor: Children's Hospital of Philadelphia
Recruiting
Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis
NCT04102371
Conditions: Shock; Septic
Interventions: Drug: Lactated Ringer; Drug: Normal Saline
Sponsors: Children's Hospital of Philadelphia; University of Pittsburgh
Not yet recruiting
Exercise Prescription for the Improvement of Quality of Life in Elderly Patients With Multiple Myeloma
NCT04100044
Condition: Plasma Cell Myeloma
Interventions: Other: Exercise Counseling; Behavioral: Exercise Intervention; Other: Questionnaire administration; Other: Quality-of-Life Assessment
Sponsor: Thomas Jefferson University
Not yet recruiting
Throwing Device Trial
NCT04098107
Condition: Overuse Injury
Intervention: Device: Throwing Device
Sponsors: Children's Hospital of Philadelphia; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting
Investigation of the Gut Microbiome on Statin Response
NCT04098003
Condition: Healthy Volunteers
Interventions: Drug: Rosuvastatin; Drug: Placebo
Sponsor: Sony Tuteja
Recruiting
Expect Respect Middle School Randomized Trial
NCT04095429
Conditions: Adolescent Behavior; Violence in Adolescence; Group, Peer; Violence, Non-accidental; Violence, Sexual; Violence, Physical; Violence, Domestic; Emotional Abuse; Coping Skills; Communication, Personal
Interventions: Behavioral: Expect Respect; Behavioral: Enhanced Usual Care
Sponsors: University of Pittsburgh; Centers for Disease Control and Prevention
Recruiting
Bicycle Exercise Echocardiography to Assess Physiological Significance of Mitral Annular Calcification
NCT04093973
Condition: Mitral Annulus Calcification
Intervention: Diagnostic Test: bicycle stress echocardiography
Sponsors: Albert Einstein Healthcare Network; Lantheus Medical Imaging
Recruiting
Use of Virtual Reality for Overdose Management Educational Trainings
NCT04091659
Conditions: Drug Overdose; Virtual Reality
Interventions: Other: Virtual Reality Education; Other: Standard Education
Sponsor: University of Pennsylvania
Enrolling by invitation
Optimize PRO Study
NCT04091048
Condition: Symptomatic Aortic Stenosis
Intervention: Device: Evolut™ PRO System
Sponsor: Medtronic Cardiovascular
Recruiting
VNS-supplemented Motor Retraining After Stroke
NCT04088578
Condition: Stroke, Acute
Interventions: Other: Training; Other: Vagus Nerve Stimulation; Other: Sham Stimulation
Sponsor: University of Pittsburgh
Recruiting
VNS-induced Corticospinal Plasticity
NCT04088565
Condition: Stroke
Interventions: Other: Paired-Associative Stimulation (PAS); Other: Vagus Nerve Stimulation (VNS); Other: Sham Stimulation
Sponsor: University of Pittsburgh
Recruiting
Restoring Molecular Circadian Rhythm
NCT04086589
Conditions: Healthy Young; Healthy Elderly
Intervention: Other: Observational study without intervention
Sponsor: University of Pennsylvania
Recruiting
Use of PECS Block in Partial Mastectomy for Postoperative Pain Control and Mitigation of Narcotic Use- A Randomized Control Trial
NCT04086394
Conditions: Breast Cancer; Partial Mastectomy; Postoperative Pain; Opioid Use; Local Anesthesia
Interventions: Procedure: Pectoral Nerve Block; Procedure: Surgery without Nerve Block
Sponsor: Main Line Health
Recruiting
Remote Electronic Patient Monitoring in Oncology Patients
NCT04086251
Condition: Cancer
Intervention: Other: Gaido
Sponsors: Gaido Health; The Guthrie Clinic
Enrolling by invitation
Sickle Cell Disease and CardiovAscular Risk - Red Cell Exchange Trial (SCD-CARRE)
NCT04084080
Condition: Sickle Cell Disease
Interventions: Biological: Red Blood Cell; Other: Standard of care
Sponsors: Mark Gladwin; National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting
Identifying Student Opinion Leaders to Lead E-cigarette Interventions
NCT04083469
Conditions: E-Cig Use; Adolescent Behavior
Interventions: Behavioral: Peer-Led Peer-Elected Intervention; Behavioral: Adult-Led Intervention; Behavioral: Peer-Led Non-Elected Intervention
Sponsors: University of Pittsburgh; University of Pittsburgh Medical Center
Recruiting
Dining With Diabetes in Pennsylvania
NCT04080960
Condition: Diabetes Mellitus, Type 2
Intervention: Behavioral: Lifestyle modification education
Sponsor: Penn State University
Recruiting
Study of Safety and Tolerability of Nivolumab Treatment Alone or in Combination With Relatlimab or Ipilimumab in Head and Neck Cancer
NCT04080804
Condition: Head and Neck Squamous Cell Carcinoma (HNSCC)
Interventions: Drug: Nivolumab; Drug: Relatlimab; Drug: Ipilimumab
Sponsors: Robert Ferris; Bristol-Myers Squibb
Recruiting
Biological Response to Brief Psychological Challenge
NCT04078035
Condition: Acute Inflammatory Response to Psychological Stress
Interventions: Behavioral: Socio-evaluative speech task, then Control; Behavioral: Control, then Socio-evaluative speech task
Sponsors: University of Pittsburgh; National Institute of Mental Health (NIMH)
Not yet recruiting
Volume vs Concentration: Quadratus Lumborum Blocks With High Volume/Low Concentration or Low Volume/ High Concentration in Nephrectomies
NCT04077398
Conditions: Analgesia; Postoperative Pain; Block
Intervention: Drug: Ropivacaine 0.5% Injectable Solution
Sponsor: Bruce Ben-David
Not yet recruiting
Memory-Updating Technique to Reduce Food Craving and High Calorie Food Intake Among Individuals With Overweight/Obesity
NCT04077385
Conditions: Overweight; Obesity; Craving; Eating Behavior
Interventions: Behavioral: Retrieval-extinction (R-E) Training; Behavioral: Extinction Training
Sponsors: University of Pittsburgh; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Not yet recruiting
Efficacy of Brock String Therapy Post Concussion
NCT04076657
Conditions: Concussion, Brain; Near Point Convergence
Interventions: Behavioral: Brock String Therapy; Behavioral: Standard of Care
Sponsor: University of Pittsburgh
Not yet recruiting
Augmenting Cognitive Behavioral Therapy With Inhibitory Control Training
NCT04076553
Conditions: Binge-Eating Disorder; Bulimia Nervosa
Interventions: Behavioral: CBT; Behavioral: ICT
Sponsor: Drexel University
Recruiting
Atrial Fibrillation Health Literacy and Information Technology Trial in Rural PA Counties
NCT04076020
Conditions: Atrial Fibrillation; Familial Atrial Fibrillation; Arrhythmia, Cardiac; Heart Diseases; Pathologic Processes
Interventions: Behavioral: Relational agent/AliveCor Kardia - Intervention Group; Behavioral: Usual Care
Sponsors: University of Pittsburgh; National Heart, Lung, and Blood Institute (NHLBI); Northeastern University; Boston University
Not yet recruiting
Atrial Fibrillation Health Literacy and Information Technology Trial in Pittsburgh, PA
NCT04075994
Conditions: Atrial Fibrillation; Familial Atrial Fibrillation; Arrythmia, Cardiac; Heart Diseases; Pathologic Processes
Interventions: Behavioral: Relational Agent and heart rate and rhythm monitor; Behavioral: Usual Care
Sponsors: University of Pittsburgh; National Heart, Lung, and Blood Institute (NHLBI); Northeastern University; Boston University
Not yet recruiting
Healthy Eating ASD
NCT04075552
Condition: Food Selectivity
Interventions: Behavioral: Pre Meal Presentation; Behavioral: Pre Meal Presentation + Modeling; Behavioral: Pre Meal Presentation + Token Economy
Sponsor: Penn State University
Recruiting
Heart at Work Study
NCT04075279
Conditions: Occupational Diseases; Cardiovascular Diseases; Cardiovascular Risk Factor; Occupational Exposure
Intervention:
Sponsor: University of Pittsburgh
Not yet recruiting
A Pilot Study of Teacher-Child Interaction Training - Universal in Head Start
NCT04075071
Conditions: Child Behavior; Child Development; Child Behavior Problem
Intervention: Behavioral: Teacher-Child Interaction Training - Universal
Sponsors: Children's Hospital of Philadelphia; PNC Foundation
Recruiting
Study of ARRY-614 Plus Either Nivolumab or Ipilimumab
NCT04074967
Conditions: Renal Cell Carcinoma; Melanoma; Solid Tumor
Interventions: Drug: Phase Ib ARRY-614 + nivolumab; Drug: Phase Ib ARRY-614 + ipilimumab; Drug: Phase II ARRY-614 + ipilimumab; Drug: Phase II ARRY-614 + nivolumab (melanoma); Drug: Phase II ARRY-614 + nivolumab (RCC)
Sponsors: Jason J. Luke, MD; Array BioPharma
Not yet recruiting
Prospective Breast Cancer Biospecimen Collection
NCT04074720
Conditions: Breast Cancer; Invasive Breast Cancer; Carcinoma in Situ of the Breast
Interventions: Procedure: Tissue Sample collection; Other: Blood Sample Collection; Other: Rectal Swab
Sponsor: Thomas Jefferson University
Recruiting
Chronic Insomnia and CSF Markers of Dementia - Effects of Treatment
NCT04073992
Condition: Insomnia Chronic
Intervention: Behavioral: cognitive behavioral treatment of insomnia
Sponsor: University of Pennsylvania
Recruiting
Evaluation of Fidaxomicin in the Treatment of Clostridium Difficile Infection (CDI)
NCT04070352
Condition: Clostridium Difficile Infection (CDI)
Intervention: Drug: Fidaxomicin
Sponsors: University of Pittsburgh; Merck Sharp & Dohme Corp.
Active, not recruiting
Mindful Response to Adversity: A Brief Stress Resilience Training
NCT04064372
Conditions: Loneliness; Depression
Interventions: Behavioral: Mindful response to adversity brief training; Behavioral: Strengths-based response to adversity brief training
Sponsor: Carnegie Mellon University
Enrolling by invitation
Evaluation of Neuroinflammation in Parkinson's Disease Using 18F-NOS PET/CT
NCT04062526
Conditions: Parkinson Disease; Healthy Volunteer
Intervention: Drug: [18F]NOS
Sponsor: University of Pennsylvania
Recruiting
Memory & Conditioning Under Anesthesia
NCT04062123
Conditions: Anesthesia; Pain
Interventions: Drug: Dexmedetomidine; Drug: Propofol; Drug: Fentanyl; Device: Peripheral Nerve Stimulation; Drug: Placebo
Sponsor: Keith M. Vogt, MD, PhD
Not yet recruiting
Improving Self-Regulation Among Adopted Children
NCT04061031
Condition: Self-regulation
Interventions: Behavioral: Parent-Child Interaction Therapy (PCIT); Behavioral: Child-Centered Therapy with Parent Education
Sponsor: Milton S. Hershey Medical Center
Recruiting
Quinine Topical Nasal Spray to Prevent Sinusitis After Endoscopic Sinus Surgery
NCT04060316
Condition: Sinusitis Chronic
Interventions: Drug: Quinine; Drug: Placebo
Sponsor: GeneOne Life Science, Inc.
Not yet recruiting
Low Nicotine Cigarettes Plus Electronic Cigarettes
NCT04058717
Condition: Tobacco Dependence
Interventions: Other: Normal Nicotine Content research cigarettes; Other: High Nicotine e-cigarette; Other: Very Low Nicotine Content research cigarettes; Other: Zero Nicotine e-cigarette
Sponsor: Milton S. Hershey Medical Center
Not yet recruiting
Digital Self-Management and Health Coaching for Type 2 Diabetes - Impact on Diabetes Clinical and Wellness Indicators
NCT04057248
Condition: Diabetes Mellitus, Type 2
Interventions: Device: Dario Blood Glucose Monitoring System; Behavioral: CDE
Sponsor: LabStyle Innovations Ltd.
Completed
Ivosidenib (AG-120) With Nivolumab in IDH1 Mutant Tumors
NCT04056910
Conditions: Advanced Solid Tumor; IDH1 Mutation; Glioma
Intervention: Drug: ivosidenib and nivolumab
Sponsors: Jason J. Luke, MD; Agios Pharmaceuticals, Inc.; Bristol-Myers Squibb (BMS)
Not yet recruiting
Pistachios Blood Sugar Control, Heart and Gut Health
NCT04056208
Conditions: Type 2 Diabetes; Cardiovascular Diseases
Interventions: Drug: Pistachio; Other: Usual care
Sponsor: Penn State University
Recruiting
Study to Assess TOPO2A as a Biomarker for Sensitivity to Doxorubicin/Doxil in Soft Tissue Sarcoma
NCT04055753
Condition: Soft Tissue Sarcoma
Interventions: Drug: Doxil; Drug: Doxorubicin
Sponsor: Fox Chase Cancer Center
Recruiting
Utilization of Telehealth to Improve Adherence to Adjuvant Endocrine Therapy in Breast Cancer Patients
NCT04054557
Conditions: Estrogen Receptor-positive Breast Cancer; Progesterone Receptor Positive Breast Cancer; Stage 0 Breast Cancer AJCC v6 and v7; Stage I Breast Cancer AJCC v7; Stage IA Breast Cancer AJCC v7; Stage IB Breast Cancer AJCC v7; Stage II Breast Cancer AJCC v6 and v7; Stage IIA Breast Cancer AJCC v6 and v7; Stage IIB Breast Cancer AJCC v6 and v7; Stage IIIA Breast Cancer AJCC v7; Stage IIIB Breast Cancer AJCC v7; Stage IIIC Breast Cancer AJCC v7
Interventions: Other: Telemedicine; Other: Best Practice; Other: Questionnaire Administration; Other: Quality-of-Life Assessment
Sponsor: Thomas Jefferson University
Recruiting
The Efficacy of Physical Activity on Improving Health Outcomes for Renal Transplant Patients and Their Caregivers
NCT04054323
Condition: Chronic Kidney Diseases
Intervention: Behavioral: Physical Activity Intervention
Sponsor: University of Pittsburgh
Not yet recruiting
METEOR Think NIV Pilot
NCT04052542
Condition: Acute Respiratory Failure
Interventions: Behavioral: Traditional online continuing education; Behavioral: Interprofessional education; Behavioral: Just-in-time education
Sponsors: University of Pittsburgh; National Heart, Lung, and Blood Institute (NHLBI)
Recruiting
Enhanced Bioscaffold for Volumetric Muscle Loss
NCT04051242
Condition: Muscle Loss
Intervention: Device: XenMatrix™ AB Surgical Graft
Sponsors: J. Peter Rubin, MD; Medical Technology Enterprise Consortium (MTEC)
Not yet recruiting
Move to Improve Physical Activity in Parkinson's Disease
NCT04051151
Conditions: Parkinson Disease; Apathy
Intervention: Behavioral: Gameficiation
Sponsor: University of Pennsylvania
Recruiting
tDCS to Treat Subacute Aphasia
NCT04048668
Conditions: Aphasia; Stroke, Acute
Intervention: Device: Transcranial Direct Current Stimulation (tDCS)
Sponsor: University of Pennsylvania
Enrolling by invitation
Topical KB105 Gene Therapy for the Treatment of TGM1-deficient Autosomal Recessive Congenital Ichthyosis (ARCI)
NCT04047732
Condition: TGM-1 Related Autosomal Recessive Congenital Ichthyosis
Intervention: Biological: KB105
Sponsor: Krystal Biotech, Inc.
Recruiting
Pneumonia in the ImmunoCompromised - Use of the Karius Test for the Detection of Undiagnosed Pathogens
NCT04047719
Conditions: Pneumonia, Bacterial; Pneumonia, Viral; Pneumonia Fungal; Pneumonia Cavitary; Immunocompromised Host
Intervention: Diagnostic Test: Karius Test
Sponsors: Karius, Inc.; Duke Clinical Research Institute
Recruiting
Safety and Pharmacokinetic Study of Tenofovir Alafenamide (TAF)/Elvitegravir (EVC) Administered Rectally
NCT04047420
Condition: HIV Infections
Intervention: Drug: TAF/EVG Insert
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); CONRAD
Not yet recruiting
Assessing the Impact of myHealth Rewards New Hire Enrollment Emails
NCT04047342
Conditions: Health Promotion; Wellness Programs
Interventions: Behavioral: Welcome email; Behavioral: Loss frame
Sponsor: Geisinger Clinic
Active, not recruiting
A Study to Evaluate Patient Characteristics and Treatment Patterns Among Rheumatoid Arthritis Patients
NCT04047121
Condition: Rheumatoid Arthritis
Intervention:
Sponsor: Pfizer
Completed
Treating Primary Progressive Aphasia (PPA) Using High-definition tDCS
NCT04046991
Condition: Primary Progressive Aphasia
Interventions: Device: high-definition transcranial direct current stimulation; Behavioral: modified constraint-induced language therapy
Sponsor: University of Pennsylvania
Not yet recruiting
Implementing Behavioral Sleep Intervention in Urban Primary Care
NCT04046341
Conditions: Sleep Disturbance; Sleep Deprivation; Sleep
Intervention: Behavioral: Sleep Well!
Sponsor: Children's Hospital of Philadelphia
Recruiting
The Parenting With Depression Study
NCT04045132
Conditions: Postpartum Depression; Parenting; Parent-Child Relations
Interventions: Behavioral: Social Media-Based Parenting Program; Behavioral: MoodGym
Sponsors: Children's Hospital of Philadelphia; National Institute of Mental Health (NIMH)
Recruiting
Magnetic Stimulation to Treat VT Storm
NCT04043312
Condition: Ventricular Tachycardia
Intervention: Device: Magstim SuperRapid
Sponsor: University of Pennsylvania
Recruiting
Novel Guidance Device for Image Fusion and Needle Guidance in Lung, Liver or Kidney Biopsy
NCT04039529
Conditions: Liver Biopsy; Lung Biopsy; Kidney Biopsy
Intervention: Device: SCENERGY-guided Biopsy
Sponsors: Clear Guide Medical; Temple University Hospital; National Institutes of Health (NIH)
Recruiting
Symptomatic Management of Lyme Arthritis
NCT04038346
Conditions: Lyme Arthritis; Lyme Disease; Arthritis
Interventions: Drug: Naproxen; Drug: Acetaminophen
Sponsor: Desiree Neville, MD
Recruiting
Ketamine to Improve Recovery After Cesarean Delivery - Part 1
NCT04037085
Conditions: Obstetric Pain; Postpartum Depression; Breastfeeding; Pain, Acute; Pain, Chronic; Obstetric Anesthesia Problems; Drug Effect; Opioid Use
Intervention: Drug: Ketamine
Sponsors: Grace Lim, MD, MS; University of Pittsburgh
Recruiting
Buddy Relationships in DermatoloGic Excisions for Skin Cancer
NCT04036344
Conditions: Skin Cancer Face; Quality of Life; Surgical Wound; Peer Mentorship
Intervention: Behavioral: Peer Mentorship Program
Sponsor: Abramson Cancer Center of the University of Pennsylvania
Active, not recruiting
Distal Radius Buckle Fracture RCT
NCT04032873
Condition: Distal Radius Fracture
Interventions: Other: Monetary Cost of Immobilization Treatments; Other: Physician; Other: Study Team; Other: Before Initial Treatment Decision; Other: After Initial Treatment Decision
Sponsor: Children's Hospital of Philadelphia
Recruiting
Griffithsin-based Rectal Microbicide for PREvention of Viral ENTry (PREVENT)
NCT04032717
Condition: HIV Prevention
Interventions: Drug: Q-Griffithsin (Q-GRFT) enema; Other: Placebo enema
Sponsors: Rhonda Brand; National Institute of Allergy and Infectious Diseases (NIAID); Intrucept Biomedicine LLC
Recruiting
Breaking Down Care Process and Patient-level Barriers to Arteriovenous Access Creation Prior to Hemodialysis Initiation
NCT04032613
Conditions: Chronic Kidney Disease; Chronic Kidney Disease Requiring Chronic Dialysis
Intervention: Other: Vascular Access Navigation and Education Quality Improvement Program
Sponsors: University of North Carolina, Chapel Hill; Geisinger Clinic; Duke University; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting
Optoacoustic Images Versus Imagio® Ultrasound
NCT04030104
Condition: Breast Cancer
Interventions: Device: Reader Study - Imagio Ultrasound; Device: Reader Study Imagio Ultrasound + Optoacoustic Imaging
Sponsor: Seno Medical Instruments Inc.
Active, not recruiting
Pitocin or Oral Misoprostol for PROM IOL
NCT04028765
Condition: PROM
Interventions: Drug: Misoprostol; Drug: Oxytocin
Sponsor: University of Pennsylvania
Recruiting
Cardiovascular Effects of CART Cell Therapy
NCT04026737
Conditions: Leukemia; Lymphoma; Cardiotoxicity; Risk Factor, Cardiovascular; Immunotherapy
Intervention:
Sponsor: Abramson Cancer Center of the University of Pennsylvania
Recruiting
Chronic Insomnia and CSF Markers of Dementia
NCT04024020
Condition: Insomnia Chronic
Intervention: Other: lumbar puncture
Sponsors: University of Pennsylvania; Merck Sharp & Dohme Corp.
Recruiting
Clinic Navigation and Home Visits to Improve Guideline-based Care and Outcomes in Low Income Minority Adults With Asthma
NCT04023422
Condition: Asthma
Interventions: Behavioral: Clinical intervention; Behavioral: Feedback
Sponsors: University of Pennsylvania; National Heart, Lung, and Blood Institute (NHLBI)
Recruiting
Risk-Guided Cardioprotection With Carvedilol in Breast Cancer Patients Treated With Doxorubicin and/or Trastuzumab
NCT04023110
Conditions: Cardiotoxicity; Risk Factor, Cardiovascular; Toxicity Due to Chemotherapy; Breast Cancer; Cardiomyopathies; Heart Failure
Intervention: Drug: Carvedilol
Sponsor: Abramson Cancer Center of the University of Pennsylvania
Recruiting
Short Course Chemo-Radiation Therapy for Patients With Newly Diagnosed Glioblastoma
NCT04019262
Condition: Glioblastoma
Interventions: Radiation: Radiation Therapy; Drug: Temozolomide Oral Product
Sponsor: John Flickinger
Not yet recruiting
Do Knee Injections Offer Benefit With Knee Arthritis Pain
NCT04017949
Condition: Knee Osteoarthritis
Intervention: Drug: Corticosteroid injection
Sponsor: University of Pittsburgh
Recruiting
Breast Milk: Influence of the Micro-transcriptome Profile on Atopy in Children and Toddlers
NCT04017520
Conditions: Atopy; Atopic Dermatitis Eczema; Wheezing; Food Allergy in Infants
Intervention:
Sponsors: Milton S. Hershey Medical Center; The Gerber Foundation
Recruiting
Decreasing Stress in Type 2 Diabetes
NCT04016415
Conditions: Stress; Diabetes Mellitus, Type 2
Interventions: Behavioral: Mindfulness Based Stress Reduction; Behavioral: Stress Management Education
Sponsors: Milton S. Hershey Medical Center; Rowan University; Penn State University; National Institutes of Health (NIH); National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Not yet recruiting
Mini Theta Burst TMS in MDD Patients
NCT04014959
Condition: Major Depressive Disorder
Intervention: Combination Product: TMS/ fMRI Stimulation
Sponsor: University of Pennsylvania
Recruiting
Taking Action: a Care for Type 2 Diabetes Intervention for Couples
NCT04014582
Condition: Type 2 Diabetes
Interventions: Behavioral: Communal Coping Intervention; Behavioral: Diabetes Education
Sponsor: Carnegie Mellon University
Recruiting
Adjuvant Treatment Determined By Pathological Response To Neoadjvuant Nivolumab
NCT04013854
Conditions: Melanoma Stage III; Melanoma
Interventions: Drug: nivolumab; Drug: Ipilimumab
Sponsor: Abramson Cancer Center of the University of Pennsylvania
Not yet recruiting
Connected Health to Decrease Opioid Use in Patients With Chronic Pain
NCT04013529
Condition: Chronic Pain
Interventions: Behavioral: Regret lottery; Behavioral: Way to Health technology enhanced care
Sponsor: University of Pennsylvania
Recruiting
Prize-linked Savings Initiatives for Promoting Better Health and Economic Outcomes in Kenya
NCT04013295
Condition: HIV/AIDS
Intervention: Other: Prize-linked savings
Sponsors: University of Pennsylvania; Impact Research & Development Organization; Innovations for Poverty Action; Bill and Melinda Gates Foundation
Completed
A Trial of Behavioral Economic Interventions Among Food Pantry Clients
NCT04011384
Condition: Food Preferences
Intervention: Behavioral: Behavioral economic intervention of online purchasing at a food pantry
Sponsors: University of Pennsylvania; Massachusetts General Hospital; University of Connecticut; National Cancer Institute (NCI)
Recruiting
Hypnosis for Bladder Pain Syndrome
NCT04010513
Conditions: Bladder Pain Syndrome; Interstitial Cystitis
Interventions: Behavioral: Hypnosis; Other: Standard of Care
Sponsor: University of Pennsylvania
Not yet recruiting
A Novel Usage of Transdermal Scopolamine in Reducing Narcotic Usage in Outpatient Hand Surgery
NCT04008264
Condition: Post Operative Pain Management
Intervention: Drug: Scopolamine Patch (Transderm V)
Sponsor: Alexander M Spiess, MD
Recruiting
Health Promoters and Organ Donation
NCT04007419
Conditions: Organ Donation; Donor Designation/Registration
Intervention: Behavioral: Health Promoters and Organ Donation
Sponsor: Temple University
Recruiting
The Value of Screening for HPR in Patients Undergoing Lower Extremity Arterial Endovascular Interventions
NCT04007055
Conditions: Peripheral Artery Disease; Clopidogrel, Poor Metabolism of; Peripheral Vascular Disease; Artery Disease; Peripheral Arterial Occlusive Disease
Interventions: Diagnostic Test: Point of care screening for HPR; Drug: Ticagrelor 90mg
Sponsor: Kyle Markel
Recruiting
Time Restricted Eating Pilot - Bariatrics
NCT04006366
Condition: Time Restricted Feeding
Intervention: Behavioral: Time restricted feeding
Sponsor: University of Pennsylvania
Enrolling by invitation
Health Education and Relationships Through Theater: An RCT of Promoting Awareness Through Live Movement and Sound for Youth With Autism Spectrum Disorder (PALMS-ASD)
NCT04005547
Conditions: Sexual Health; Education, Health
Intervention: Behavioral: Promoting Awareness through Live Movement and Sound for youth with Autism Spectrum Disorder
Sponsors: Public Health Management Corporation; Temple University
Recruiting
A Study to Evaluate Abemaciclib in Advanced Biliary Tract Carcinoma Who Failed Prior First Line Therapy
NCT04003896
Condition: Biliary Tract Carcinoma
Intervention: Drug: Abemaciclib
Sponsors: Milton S. Hershey Medical Center; Eli Lilly and Company
Not yet recruiting
The Effect of Prolonged Multimodal Analgesic Regimen on Post Hospital Discharge Opioid Use and Pain Control After Primary Total Knee Arthroplasty
NCT04003350
Condition: Osteo Arthritis Knee
Interventions: Drug: Oxycodone; Drug: Tramadol; Drug: Tylenol; Drug: Meloxicam; Drug: Gabapentin; Drug: Metaxalone; Drug: Esomeprazole 20mg
Sponsor: Rothman Institute Orthopaedics
Completed
Superficial Peroneal Nerve Neuromodulation for Non-Obstructive Urinary Retention
NCT04000763
Conditions: Urinary Retention; Urinary Bladder, Underactive
Intervention: Device: superficial peroneal nerve stimulation
Sponsors: Katherine Shapiro; Society of Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction; University of North Carolina, Chapel Hill
Not yet recruiting
Insulin Start Therapy Application With Resources and Training
NCT03999268
Condition: Diabetes Mellitus, Type 2
Interventions: Behavioral: I-START; Behavioral: Standard Insulin Administration Education
Sponsor: University of Pittsburgh
Not yet recruiting
The Impact of a Home-based Pulmonary Telerehabilitation Program in Acute Exacerbations of COPD
NCT03997513
Condition: Pulmonary Disease, Chronic Obstructive
Intervention: Behavioral: Pulmonary Telerehabilitation
Sponsor: VA Office of Research and Development
Not yet recruiting
Prevention of Unmitigated Chemotherapy-induced Emesis
NCT03996863
Conditions: Chemotherapy-induced Nausea and Vomiting; Nausea Post Chemotherapy
Interventions: Device: Otoband; Device: Placebo device
Sponsors: Otolith Labs; Drexel University College of Medicine
Not yet recruiting
Medication Adherence and Outcomes Among Patients in United States With HIV
NCT03995745
Conditions: Human Immunodeficiency Virus; Medication Adherence
Intervention: Behavioral: Medication adherence and financial incentives
Sponsors: University of Pennsylvania; Drexel University
Recruiting
Effect of rTMS on Anxiety
NCT03993509
Conditions: Anxiety; Fear; Anxiety and Fear
Intervention: Device: rTMS to the right dlPFC
Sponsor: University of Pennsylvania
Recruiting
A Study of a Values-Based Intervention to Promote Weight Loss
NCT03991676
Conditions: Obesity; Weight Loss
Intervention: Behavioral: Values-Based Behavioral Treatment
Sponsor: Drexel University
Completed
Vessel Wall MR Imaging to Explore Sex-Differences of Intracranial Arterial Wall Changes After Suspected Stroke
NCT03990545
Conditions: Intracranial Atherosclerosis; Acute Stroke; Transient Ischemic Attack
Intervention:
Sponsor: University of Pennsylvania
Recruiting
Prospective Use of Awake Endoscopy for Inspire Activation
NCT03990298
Condition: Obstructive Sleep Apnea
Intervention: Diagnostic Test: Awake endoscopy
Sponsor: University of Pennsylvania
Enrolling by invitation
[18F]Fluciclovine in Post-treatment Glioblastoma ( Axumin )
NCT03990285
Condition: Glioma Glioblastoma Multiforme
Intervention: Drug: Axumin, Intravenous Solution
Sponsors: Seyed Ali Nabavizadeh, MD; Blue Earth Diagnostics
Recruiting
Biological Effects of Quercetin in COPD
NCT03989271
Condition: Chronic Obstructive Pulmonary Disease
Intervention: Drug: Quercetin
Sponsors: Temple University; National Institutes of Health (NIH); Quercegen Pharmaceuticals; National Center for Complementary and Integrative Health (NCCIH)
Recruiting
Improving Self-care of Heart Failure Caregivers
NCT03988621
Condition: Heart Failure
Intervention: Behavioral: ViCCY
Sponsor: University of Pennsylvania
Recruiting
Open Label Pharmaco- Magnetic Resonance Spectrography (MRS) Study of Clavulanic Acid
NCT03986762
Conditions: Cocaine Dependence, in Remission; Cocaine Abuse, in Remission; Cocaine-Related Disorders
Intervention: Drug: Clavulanic Acid
Sponsors: Temple University; National Institute on Drug Abuse (NIDA)
Recruiting
Mindfulness-based Dance/Movement Therapy for Chronic Low Back Pain
NCT03986489
Condition: Chronic Low-back Pain
Interventions: Behavioral: Mindfulness-based dance/movement therapy (M-DMT); Behavioral: Chronic pain social support group
Sponsors: Drexel University; National Center for Complementary and Integrative Health (NCCIH); Stony Brook University
Recruiting
Specialty Medical Homes to Improve Outcomes for Patients With IBD and Behavioral Health Conditions
NCT03985800
Conditions: Inflammatory Bowel Disease; Behavioral Symptoms
Interventions: Other: TEAM; Other: TECH
Sponsors: University of Pittsburgh; Mount Sinai Hospital, New York; The Cleveland Clinic; Patient-Centered Outcomes Research Institute
Recruiting
Machine-Generated Mortality Estimates and Nudges to Promote Advance Care Planning Discussion Among Cancer Patients
NCT03984773
Condition: Oncology
Intervention: Behavioral: Nudge
Sponsor: University of Pennsylvania
Enrolling by invitation
Heart Failure Self-care Mobile Application to Reduce Readmissions Trial
NCT03982017
Condition: Heart Failure
Interventions: Other: Mobile Health Technology Platform; Other: Usual care
Sponsors: University of Pittsburgh; Agency for Healthcare Research and Quality (AHRQ)
Recruiting
Nurse AMIE: Addressing Metastatic Individuals Everyday
NCT03975621
Condition: Metastatic Breast Cancer
Intervention: Behavioral: Supportive Care
Sponsor: Milton S. Hershey Medical Center
Recruiting
Understanding Trauma Nightmares Using In-Home Measurement
NCT03974503
Conditions: Nightmares; Stress Disorders, Post-Traumatic; Actigraphy; Respiratory Sinus Arrhythmia; Veterans
Interventions: Behavioral: Exposure, Relaxation, and Rescripting Therapy; Behavioral: Sleep and Nightmare Management
Sponsor: VA Office of Research and Development
Recruiting
Penn Microbiome Therapy for Recurrent Clostridium Difficile Infection
NCT03973697
Condition: Recurrent Clostridium Difficile Infection
Interventions: Drug: Penn Microbiome Therapy - 001; Drug: Penn Microbiome Therapy - 002; Drug: Penn Microbiome Therapy - 003
Sponsor: University of Pennsylvania
Not yet recruiting
Impact of Serious Pediatric Illness on Parent and Sibling Health
NCT03971344
Conditions: Family Members of: Newborns Extremely Premature; Family Members of: New Pediatric Oncology Patients; Family Members of: Critical Congenital Heart Defect Patients; Family Members of: Children Severe Neurological Impairment
Intervention:
Sponsors: Children's Hospital of Philadelphia; Cigna Foundation
Enrolling by invitation
The Effect of Self-Forgiveness on Self-Stigma in Addiction.
NCT03971097
Conditions: Substance Use Disorders; Opiate Dependence; Opiate Withdrawal Syndrome; Opioid-use Disorder; Alcohol Withdrawal; Alcohol Abuse; Alcohol Use Disorder; Cocaine Abuse; Cocaine Use Disorder; Cocaine Withdrawal; Benzodiazepine Abuse; Benzodiazepine Dependence; Substance Abuse; Heroin Overdoses; Heroin Withdrawal; Heroin Abuse
Interventions: Behavioral: Six Step Model of Self-Forgiveness; Behavioral: Treatment as Usual (TAU)
Sponsors: University of Pittsburgh; Indiana University of Pennsylvania
Recruiting
PMT for Severe-CDI
NCT03970200
Conditions: Severe Clostridium Difficile Infection; Severe-Complicated/Fulminant Clostridium Difficile Infection
Interventions: Drug: Penn Microbiome Therapy - 001; Drug: Penn Microbiome Therapy - 002; Drug: Penn Microbiome Therapy - 003; Drug: Antibiotics
Sponsor: University of Pennsylvania
Not yet recruiting
Abemaciclib in Patients With Oligodendroglioma
NCT03969706
Condition: Oligodendroglioma, Adult
Intervention: Drug: Abemaciclib 200 MG
Sponsor: University of Pennsylvania
Recruiting
Telehealth Intervention in Cirrhotics
NCT03969186
Conditions: Cirrhosis, Liver; Liver Diseases
Intervention: Behavioral: Intervention
Sponsor: University of Pennsylvania
Recruiting
MOVE UP Lifestyle Intervention for Caregivers
NCT03967912
Conditions: Body Weight; Healthy Diet; Physical Activity; Health Behavior; Healthy Aging
Intervention: Behavioral: MOVE UP
Sponsors: University of Pittsburgh; Centers for Disease Control and Prevention
Not yet recruiting
Assessing the Impact of myHealth Rewards Enrollment Emails
NCT03965754
Conditions: Health Promotion; Wellness Programs
Interventions: Behavioral: Social norms; Behavioral: Loss framing; Behavioral: Email reminder
Sponsor: Geisinger Clinic
Active, not recruiting
Developing an Injury Prevention Simulation Game to Better Engage Parents in Services -Home Safety Hero
NCT03965377
Condition: Parenting
Intervention: Behavioral: Home Safety Hero Computer Game
Sponsor: Penn State University
Enrolling by invitation
Priming With tDCS: Expanding the Window of Recovery in Chronic Stroke
NCT03964467
Condition: Upper Extremity Paresis
Intervention: Device: transcranial direct current stimulation
Sponsors: University of the Sciences in Philadelphia; Chapman University; Moss Rehabilitation Research Institute; Thomas Jefferson University
Recruiting
Sustainability of MOVE UP Lifestyle Intervention
NCT03963830
Conditions: Body Weight; Diet, Healthy; Physical Disability
Intervention: Behavioral: MOVE UP
Sponsors: University of Pittsburgh; Centers for Disease Control and Prevention
Recruiting
Molecular Basis of Pediatric Liver Cancer
NCT03959800
Conditions: Childhood Liver Cancer; Liver Malignant Tumors; Embryonal Sarcoma of Liver (Disorder); Hepatoblastoma; Hepatocellular Carcinoma; Rhabdoid Tumor of Liver
Intervention:
Sponsor: University of Pittsburgh
Recruiting
Cardiac Cath Lab Staff Radiation Exposure
NCT03959072
Conditions: Coronary Artery Disease; Chronic Total Occlusion of Coronary Artery; Percutaneous Coronary Intervention
Interventions: Device: Robotic CTO PCI; Procedure: Conventional (Manual) CTO PCI
Sponsor: Corindus Inc.
Not yet recruiting
Palliative Care Consultations in the Skilled Nursing Facility (SNF) Setting
NCT03958552
Conditions: Palliative Care; Advance Care Planning; Skilled Nursing Facilities
Intervention: Other: Palliative Care Consultation
Sponsor: University of Pennsylvania
Enrolling by invitation
A Study Based on Medical Records That Looks at the Characteristics of Idiopathic Pulmonary Fibrosis Patients Grouped by the Type of Medication They Are Taking
NCT03958071
Condition: Idiopathic Pulmonary Fibrosis
Interventions: Drug: Nintedanib; Drug: Pirfenidone; Other: Untreated Cohort
Sponsor: Boehringer Ingelheim
Active, not recruiting
Hyperthermia and Olaparib in Treating Breast Cancer Patients With Chest Wall Recurrences
NCT03955640
Conditions: Metastatic Malignant Neoplasm in the Chest Wall; Recurrent Breast Carcinoma
Interventions: Drug: Olaparib; Procedure: Hyperthermia Treatment; Other: Questionnaire Administration; Other: Quality-of-Life Assessment
Sponsors: Thomas Jefferson University; AstraZeneca
Recruiting
POC SPLA2-IIA as a Biomarker for Sepsis and Septic Shock
NCT03953404
Condition: Sepsis
Intervention: Diagnostic Test: SPLA2-IIA
Sponsor: St. Luke's Hospital, Pennsylvania
Recruiting
HeartPhone Cancer Survivors Trial 2019
NCT03953326
Conditions: Breast Cancer; Leukemia; Lymphoma
Interventions: Behavioral: HeartPhone app; Drug: Acetylcholine; Drug: Sodium Nitroprusside; Drug: L-Arginine, N2-((4-Methylphenyl)Sulfonyl)-, Methyl Ester
Sponsor: Penn State University
Recruiting
Reducing Sedentary Behavior to Improve Sleep: an Ancillary Study to the RESET BP Clinical Trial
NCT03946228
Conditions: Sleep; Obstructive Sleep Apnea; Insomnia
Intervention: Behavioral: Behavioral Intervention
Sponsors: University of Pittsburgh; National Heart, Lung, and Blood Institute (NHLBI)
Enrolling by invitation
Healthy Mom Zone: A Gestational Weight Gain Management Intervention
NCT03945266
Conditions: Overweight and Obesity; Physical Activity; Weight Change, Body; Eating Behavior
Interventions: Behavioral: Intervention group; Behavioral: Control group
Sponsors: Penn State University; National Heart, Lung, and Blood Institute (NHLBI); Arizona State University
Completed
Virtual Reality-enhanced Exercise and Education in Cardiac Rehabilitation
NCT03945201
Conditions: Adherence, Patient; Motivation; Satisfaction
Interventions: Other: Virtual walking trails; Other: Standard of care
Sponsor: Thomas Jefferson University
Completed
Genetics and Shared Decision Making in Improving Care for Patients With Stage IVA-C Non-small Cell Lung Cancer
NCT03944265
Conditions: Activating ALK Gene Mutation Negative; Activating EGFR Gene Mutation Negative; Activating ROS1 Gene Mutation Negative; Health Care Provider; Lung Non-Small Cell Carcinoma; Stage IV Lung Cancer AJCC v8; Stage IVA Lung Cancer AJCC v8; Stage IVB Lung Cancer AJCC v8
Interventions: Other: Counseling; Other: Questionnaire Administration; Other: Medical Chart Review
Sponsor: Thomas Jefferson University
Recruiting
Development and Initial Tests of Reward Re-Training: A Novel Treatment For Reward Dysfunction
NCT03942874
Conditions: Binge Eating; Binge-Eating Disorder; Bulimia Nervosa
Intervention: Behavioral: Group Reward Retraining
Sponsor: Drexel University
Enrolling by invitation
Using Digital Health, Financial Incentives, and Community Health Worker Support to Change Health Behavior
NCT03939793
Condition: Diabetes Mellitus
Interventions: Behavioral: IMPaCT Community Health Worker; Behavioral: Digital health monitoring with financial incentives; Other: Usual Care
Sponsors: University of Pennsylvania; The Commonwealth Fund
Recruiting
NGS for Non-unions
NCT03937310
Condition: Nonunion of Fracture
Intervention: Diagnostic Test: Next-generation sequencing of swabs collected during surgery
Sponsor: Rothman Institute Orthopaedics
Enrolling by invitation
Study of Humidified Air to Improve Mucociliary Clearance (MCC) in COPD
NCT03935932
Condition: COPD
Intervention: Device: nasal delivery of heated and humidified air
Sponsors: Frank C Sciurba; Fisher and Paykel Healthcare
Recruiting
Adoptive Transfer of Tumor Infiltrating Lymphocytes for Advanced Solid Cancers
NCT03935893
Conditions: Gastric Cancer; Colorectal Cancer; Pancreatic Cancer; Sarcoma; Mesothelioma; Neuroendocrine Tumors; Squamous Cell Cancer; Merkel Cell Carcinoma; Mismatch Repair Deficiency; Microsatellite Instability
Interventions: Biological: Tumor Infiltrating Lymphocytes (TIL); Drug: Fludarabine + Cyclophosphamide combination
Sponsor: Udai Kammula
Recruiting
Evaluating an Alternative Clinical Genetics Cancer Care Deliver Model
NCT03934606
Conditions: Pancreas Cancer; Prostate Cancer; Hereditary Cancer; Genetic Predisposition to Disease
Intervention: Behavioral: Genetic testing for hereditary predisposition
Sponsor: University of Pennsylvania
Recruiting
A Study for the Assessment of the Benefits of a Novel Mesh Nebulizer in the Treatment of Patients With Stable COPD
NCT03933462
Condition: COPD
Interventions: Device: InnoSpire Go; Device: Jet Nebulizer
Sponsor: Philips Respironics
Completed
Circulating miRNA in Primary Hyperparathyroidism
NCT03931109
Conditions: Primary Hyperparathyroidism; Osteoporosis, Postmenopausal
Intervention:
Sponsor: University of Pennsylvania
Recruiting
Coping Together After Breast Cancer
NCT03930797
Condition: Breast Cancer
Interventions: Behavioral: Intimacy Enhancement; Behavioral: Living Healthy Together
Sponsors: Fox Chase Cancer Center; National Cancer Institute (NCI)
Recruiting
Proactive Outreach and Shared Decision Making in Improving Lung Cancer Screening Rates in Primary Care Patients
NCT03929926
Condition: Lung Cancer
Interventions: Other: Best Practice; Behavioral: Cancer Educational Materials; Other: Behavioral, Psychological or Informational Intervention; Other: Counseling
Sponsor: Thomas Jefferson University
Recruiting
Contrast Enhanced Mammography in Diagnosing Patients With Suspicious Breast Findings
NCT03929783
Condition: Breast Neoplasms
Intervention: Procedure: Contrast Enhanced Digital Mammography
Sponsor: Thomas Jefferson University
Not yet recruiting
Management Of Pain After Cesarean Trial
NCT03929640
Conditions: Pain, Postoperative; Opioid Use
Interventions: Drug: Acetaminophen; Drug: Placebo; Drug: Ibuprofen
Sponsor: Milton S. Hershey Medical Center
Recruiting
Shifting Perspectives: Enhancing Outcomes in Anorexia Nervosa With CRT
NCT03928028
Condition: Anorexia Nervosa
Interventions: Behavioral: Cognitive Remediation Therapy; Behavioral: Family Based Treatment
Sponsor: Children's Hospital of Philadelphia
Recruiting
First - In - Man Study to Assess the Safety and Feasibility of The Bashir™ Endovascular Catheter for the Treatment of Acute Pulmonary Embolism
NCT03927508
Condition: Pulmonary Embolism
Interventions: Drug: r-tPA; Device: The Bashir™ Endovascular Catheter
Sponsor: Thrombolex, Inc.
Recruiting
Variations in Palatability and Portion Size of Vegetables on Meal Intake of Preschool Children
NCT03926065
Condition: Feeding Behavior
Interventions: Other: Plain Vegetables Served in 100% Portion Size; Other: Plain Vegetables Served in 200% Portion Size; Other: Enhanced Vegetables Served in 100% Portion Size; Other: Enhanced Vegetables Served in 200% Portion Size
Sponsors: Penn State University; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting

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