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Pennsylvania

• Quinine Topical Nasal Spray to Prevent Sinusitis After Endoscopic Sinus Surgery

  NCT04060316

  Condition:   Sinusitis Chronic
  Interventions:   Drug: Quinine;   Drug: Placebo
  Sponsor:   GeneOne Life Science, Inc.
  Not yet recruiting
• Low Nicotine Cigarettes Plus Electronic Cigarettes

  NCT04058717

  Condition:   Tobacco Dependence
  Interventions:   Other: Normal Nicotine Content research cigarettes;   Other: High Nicotine e-cigarette;   Other: Very Low Nicotine Content research cigarettes;   Other: Zero Nicotine e-cigarette
  Sponsor:   Milton S. Hershey Medical Center
  Not yet recruiting
• Digital Self-Management and Health Coaching for Type 2 Diabetes - Impact on Diabetes Clinical and Wellness Indicators

  NCT04057248

  Condition:   Diabetes Mellitus, Type 2
  Interventions:   Device: Dario Blood Glucose Monitoring System;   Behavioral: CDE
  Sponsor:   LabStyle Innovations Ltd.
  Completed
• Phase II Trial of Ivosidenib (AG-120) With Nivolumab in IDH1 Mutant Tumors

  NCT04056910

  Conditions:   Advanced Solid Tumor;   IDH1 Mutation;   Glioma
  Intervention:   Drug: ivosidenib and nivolumab
  Sponsors:   Jason Luke;   Agios Pharmaceuticals, Inc.;   Bristol-Myers Squibb (BMS)
  Not yet recruiting
• Study to Assess TOPO2A as a Biomarker for Sensitivity to Doxorubicin/Doxil in Soft Tissue Sarcoma

  NCT04055753

  Condition:   Soft Tissue Sarcoma
  Interventions:   Drug: Doxil;   Drug: Doxorubicin
  Sponsor:   Fox Chase Cancer Center
  Recruiting
• Utilization of Telehealth to Improve Adherence to Adjuvant Endocrine Therapy in Breast Cancer Patients

  NCT04054557

  Conditions:   Estrogen Receptor-positive Breast Cancer;   Progesterone Receptor Positive Breast Cancer;   Stage 0 Breast Cancer AJCC v6 and v7;   Stage I Breast Cancer AJCC v7;   Stage IA Breast Cancer AJCC v7;   Stage IB Breast Cancer AJCC v7;   Stage II Breast Cancer AJCC v6 and v7;   Stage IIA Breast Cancer AJCC v6 and v7;   Stage IIB Breast Cancer AJCC v6 and v7;   Stage IIIA Breast Cancer AJCC v7;   Stage IIIB Breast Cancer AJCC v7;   Stage IIIC Breast Cancer AJCC v7
  Interventions:   Other: Telemedicine;   Other: Best Practice;   Other: Questionnaire Administration;   Other: Quality-of-Life Assessment
  Sponsor:   Thomas Jefferson University
  Recruiting
• The Efficacy of Physical Activity on Improving Health Outcomes for Renal Transplant Patients and Their Caregivers

  NCT04054323

  Condition:   Chronic Kidney Diseases
  Intervention:   Behavioral: Physical Activity Intervention
  Sponsor:   University of Pittsburgh
  Not yet recruiting
• METEOR Think NIV Pilot

  NCT04052542

  Condition:   Acute Respiratory Failure
  Interventions:   Behavioral: Traditional online continuing education;   Behavioral: Interprofessional education;   Behavioral: Just-in-time education
  Sponsors:   University of Pittsburgh;   National Heart, Lung, and Blood Institute (NHLBI)
  Not yet recruiting
• Enhanced Bioscaffold for Volumetric Muscle Loss

  NCT04051242

  Condition:   Muscle Loss
  Intervention:   Device: XenMatrix™ AB Surgical Graft
  Sponsors:   J. Peter Rubin, MD;   Medical Technology Enterprise Consortium (MTEC)
  Not yet recruiting
• Move to Improve Physical Activity in Parkinson's Disease

  NCT04051151

  Conditions:   Parkinson Disease;   Apathy
  Intervention:   Behavioral: Gameficiation
  Sponsor:   University of Pennsylvania
  Recruiting
• tDCS to Treat Subacute Aphasia

  NCT04048668

  Conditions:   Aphasia;   Stroke, Acute
  Intervention:   Device: Transcranial Direct Current Stimulation (tDCS)
  Sponsor:   University of Pennsylvania
  Enrolling by invitation
• Topical KB105 Gene Therapy for the Treatment of TGM1-deficient Autosomal Recessive Congenital Ichthyosis (ARCI)

  NCT04047732

  Condition:   TGM-1 Related Autosomal Recessive Congenital Ichthyosis
  Intervention:   Biological: KB105
  Sponsor:   Krystal Biotech, Inc.
  Not yet recruiting
• Assessing the Impact of myHealth Rewards New Hire Enrollment Emails

  NCT04047342

  Conditions:   Health Promotion;   Wellness Programs
  Interventions:   Behavioral: Welcome email;   Behavioral: Loss frame
  Sponsor:   Geisinger Clinic
  Active, not recruiting
• This is a Retrospective Cohort Study to Evaluate Patient Characteristics and Treatment Patterns Among Rheumatoid Arthritis Patients

  NCT04047121

  Condition:   Rheumatoid Arthritis
  Intervention:  
  Sponsor:   Pfizer
  Active, not recruiting
• Treating Primary Progressive Aphasia (PPA) Using High-definition tDCS

  NCT04046991

  Condition:   Primary Progressive Aphasia
  Interventions:   Device: high-definition transcranial direct current stimulation;   Behavioral: modified constraint-induced language therapy
  Sponsor:   University of Pennsylvania
  Not yet recruiting
• The Parenting With Depression Study

  NCT04045132

  Conditions:   Postpartum Depression;   Parenting;   Parent-Child Relations
  Interventions:   Behavioral: Social Media-Based Parenting Program;   Behavioral: MoodGym
  Sponsors:   Children's Hospital of Philadelphia;   National Institute of Mental Health (NIMH)
  Not yet recruiting
• Magnetic Stimulation to Treat VT Storm Tachycardia Storm

  NCT04043312

  Condition:   Ventricular Tachycardia
  Intervention:   Device: Magstim SuperRapid
  Sponsor:   University of Pennsylvania
  Recruiting
• Novel Guidance Device for Image Fusion and Needle Guidance in Lung, Liver or Kidney Biopsy

  NCT04039529

  Conditions:   Liver Biopsy;   Lung Biopsy;   Kidney Biopsy
  Intervention:   Device: SCENERGY-guided Biopsy
  Sponsors:   Clear Guide Medical;   Temple University Hospital;   National Institutes of Health (NIH)
  Recruiting
• Symptomatic Management of Lyme Arthritis

  NCT04038346

  Conditions:   Lyme Arthritis;   Lyme Disease;   Arthritis
  Interventions:   Drug: Naproxen;   Drug: Acetaminophen
  Sponsor:   Desiree Neville, MD
  Not yet recruiting
• Niraparib With Standard Combination Radiation Therapy and Androgen Deprivation Therapy in Treating Patients With High Risk Prostate Cancer

  NCT04037254

  Conditions:   Prostate Adenocarcinoma;   Stage IIC Prostate Cancer AJCC v8;   Stage III Prostate Cancer AJCC v8;   Stage IIIA Prostate Cancer AJCC v8;   Stage IIIB Prostate Cancer AJCC v8;   Stage IIIC Prostate Cancer AJCC v8;   Stage IVA Prostate Cancer AJCC v8
  Interventions:   Biological: Gonadotrophin Releasing Hormone;   Radiation: Intensity-Modulated Radiation Therapy;   Drug: Niraparib
  Sponsors:   NRG Oncology;   National Cancer Institute (NCI)
  Recruiting
• Buddy Relationships in DermatoloGic Excisions for Skin Cancer

  NCT04036344

  Conditions:   Skin Cancer Face;   Quality of Life;   Surgical Wound;   Peer Mentorship
  Intervention:   Behavioral: Peer Mentorship Program
  Sponsor:   Abramson Cancer Center of the University of Pennsylvania
  Active, not recruiting
• Distal Radius Buckle Fracture RCT

  NCT04032873

  Condition:   Distal Radius Fracture
  Interventions:   Other: Monetary Cost of Immobilization Treatments;   Other: Physician;   Other: Study Team;   Other: Before Initial Treatment Decision;   Other: After Initial Treatment Decision
  Sponsor:   Children's Hospital of Philadelphia
  Recruiting
• Griffithsin-based Rectal Microbicide for PREvention of Viral ENTry (PREVENT)

  NCT04032717

  Condition:   HIV Prevention
  Interventions:   Drug: Q-Griffithsin (Q-GRFT) enema;   Other: Placebo enema
  Sponsors:   Rhonda Brand;   National Institute of Allergy and Infectious Diseases (NIAID);   Intrucept Biomedicine LLC
  Recruiting
• Breaking Down Care Process and Patient-level Barriers to Arteriovenous Access Creation Prior to Hemodialysis Initiation

  NCT04032613

  Conditions:   Chronic Kidney Disease;   Chronic Kidney Disease Requiring Chronic Dialysis
  Intervention:   Other: Vascular Access Navigation and Education Quality Improvement Program
  Sponsors:   University of North Carolina, Chapel Hill;   Geisinger Clinic;   Duke University;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
  Not yet recruiting
• Optoacoustic Images Versus Imagio® Ultrasound

  NCT04030104

  Condition:   Breast Cancer
  Interventions:   Device: Reader Study - Imagio Ultrasound;   Device: Reader Study Imagio Ultrasound + Optoacoustic Imaging
  Sponsor:   Seno Medical Instruments Inc.
  Active, not recruiting
• Pitocin or Oral Misoprostol for PROM IOL

  NCT04028765

  Condition:   PROM
  Interventions:   Drug: Misoprostol;   Drug: Oxytocin
  Sponsor:   University of Pennsylvania
  Recruiting
• Cardiovascular Effects of CART Cell Therapy

  NCT04026737

  Conditions:   Leukemia;   Lymphoma;   Cardiotoxicity;   Risk Factor, Cardiovascular;   Immunotherapy
  Intervention:  
  Sponsor:   Abramson Cancer Center of the University of Pennsylvania
  Recruiting
• Chronic Insomnia and CSF Markers of Dementia

  NCT04024020

  Condition:   Insomnia Chronic
  Intervention:   Other: lumbar puncture
  Sponsors:   University of Pennsylvania;   Merck Sharp & Dohme Corp.
  Recruiting
• Clinic Navigation and Home Visits to Improve Guideline-based Care and Outcomes in Low Income Minority Adults With Asthma

  NCT04023422

  Condition:   Asthma
  Interventions:   Behavioral: Clinical intervention;   Behavioral: Feedback
  Sponsors:   University of Pennsylvania;   National Heart, Lung, and Blood Institute (NHLBI)
  Recruiting
• Risk-Guided Cardioprotection With Carvedilol in Breast Cancer Patients Treated With Doxorubicin and/or Trastuzumab

  NCT04023110

  Conditions:   Cardiotoxicity;   Risk Factor, Cardiovascular;   Toxicity Due to Chemotherapy;   Breast Cancer;   Cardiomyopathies;   Heart Failure
  Intervention:   Drug: Carvedilol
  Sponsor:   Abramson Cancer Center of the University of Pennsylvania
  Not yet recruiting
• Short Course Chemo-Radiation Therapy for Patients With Newly Diagnosed Glioblastoma

  NCT04019262

  Condition:   Glioblastoma
  Interventions:   Radiation: Radiation Therapy;   Drug: Temozolomide Oral Product
  Sponsor:   John Flickinger
  Not yet recruiting
• Breast Milk: Influence of the Micro-transcriptome Profile on Atopy in Children and Toddlers

  NCT04017520

  Conditions:   Atopy;   Atopic Dermatitis Eczema;   Wheezing;   Food Allergy in Infants
  Intervention:  
  Sponsors:   Milton S. Hershey Medical Center;   The Gerber Foundation;   Center for Research On Women and Newborns
  Recruiting
• Decreasing Stress in Type 2 Diabetes

  NCT04016415

  Conditions:   Stress;   Diabetes Mellitus, Type 2
  Interventions:   Behavioral: Mindfulness Based Stress Reduction;   Behavioral: Stress Management Education
  Sponsors:   Milton S. Hershey Medical Center;   Rowan University;   Penn State University;   National Institutes of Health (NIH);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
  Not yet recruiting
• Mini Theta Burst TMS in MDD Patients

  NCT04014959

  Condition:   Major Depressive Disorder
  Intervention:   Combination Product: TMS/ fMRI Stimulation
  Sponsor:   University of Pennsylvania
  Recruiting
• Taking Action: a Care for Type 2 Diabetes Intervention for Couples

  NCT04014582

  Condition:   Type 2 Diabetes
  Interventions:   Behavioral: Communal Coping Intervention;   Behavioral: Diabetes Education
  Sponsor:   Carnegie Mellon University
  Recruiting
• Adjuvant Treatment Determined By Pathological Response To Neoadjvuant Nivolumab

  NCT04013854

  Conditions:   Melanoma Stage III;   Melanoma
  Interventions:   Drug: nivolumab;   Drug: Ipilimumab
  Sponsor:   Abramson Cancer Center of the University of Pennsylvania
  Not yet recruiting
• Connected Health to Decrease Opioid Use in Patients With Chronic Pain

  NCT04013529

  Condition:   Chronic Pain
  Interventions:   Behavioral: Regret lottery;   Behavioral: Way to Health technology enhanced care
  Sponsor:   University of Pennsylvania
  Recruiting
• Prize-linked Savings Initiatives for Promoting Better Health and Economic Outcomes in Kenya

  NCT04013295

  Condition:   HIV/AIDS
  Intervention:   Other: Prize-linked savings
  Sponsors:   University of Pennsylvania;   Impact Research & Development Organization;   Innovations for Poverty Action;   Bill and Melinda Gates Foundation
  Completed
• A Trial of Behavioral Economic Interventions Among Food Pantry Clients

  NCT04011384

  Condition:   Food Preferences
  Intervention:   Behavioral: Behavioral economic intervention of online purchasing at a food pantry
  Sponsors:   University of Pennsylvania;   Massachusetts General Hospital;   University of Connecticut;   National Cancer Institute (NCI)
  Recruiting
• Hypnosis for Bladder Pain Syndrome

  NCT04010513

  Conditions:   Bladder Pain Syndrome;   Interstitial Cystitis
  Interventions:   Behavioral: Hypnosis;   Other: Standard of Care
  Sponsor:   University of Pennsylvania
  Not yet recruiting
• Health Promoters and Organ Donation

  NCT04007419

  Conditions:   Organ Donation;   Donor Designation/Registration
  Intervention:   Behavioral: Health Promoters and Organ Donation
  Sponsor:   Temple University
  Recruiting
• The Value of Screening for HPR in Patients Undergoing Lower Extremity Arterial Endovascular Interventions

  NCT04007055

  Conditions:   Peripheral Artery Disease;   Clopidogrel, Poor Metabolism of;   Peripheral Vascular Disease;   Artery Disease;   Peripheral Arterial Occlusive Disease
  Interventions:   Diagnostic Test: Point of care screening for HPR;   Drug: Ticagrelor 90mg
  Sponsor:   Kyle Markel
  Recruiting
• Time Restricted Eating Pilot - Bariatrics

  NCT04006366

  Condition:   Time Restricted Feeding
  Intervention:   Behavioral: Time restricted feeding
  Sponsor:   University of Pennsylvania
  Enrolling by invitation
• Health Education and Relationships Through Theater: An RCT of Promoting Awareness Through Live Movement and Sound for Youth With Autism Spectrum Disorder (PALMS-ASD)

  NCT04005547

  Conditions:   Sexual Health;   Education, Health
  Intervention:   Behavioral: Promoting Awareness through Live Movement and Sound for youth with Autism Spectrum Disorder
  Sponsors:   Public Health Management Corporation;   Temple University
  Recruiting
• A Study to Evaluate Abemaciclib in Advanced Biliary Tract Carcinoma Who Failed Prior First Line Therapy

  NCT04003896

  Condition:   Biliary Tract Carcinoma
  Intervention:   Drug: Abemaciclib
  Sponsors:   Milton S. Hershey Medical Center;   Eli Lilly and Company
  Not yet recruiting
• The Effect of Prolonged Multimodal Analgesic Regimen on Post Hospital Discharge Opioid Use and Pain Control After Primary Total Knee Arthroplasty

  NCT04003350

  Condition:   Osteo Arthritis Knee
  Interventions:   Drug: Oxycodone;   Drug: Tramadol;   Drug: Tylenol;   Drug: Meloxicam;   Drug: Gabapentin;   Drug: Metaxalone;   Drug: Esomeprazole 20mg
  Sponsor:   Rothman Institute Orthopaedics
  Completed
• Superficial Peroneal Nerve Neuromodulation for Non-Obstructive Urinary Retention

  NCT04000763

  Conditions:   Urinary Retention;   Urinary Bladder, Underactive
  Intervention:   Device: superficial peroneal nerve stimulation
  Sponsors:   Katherine Shapiro;   Society of Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction;   University of North Carolina, Chapel Hill
  Not yet recruiting
• Insulin Start Therapy Application With Resources and Training

  NCT03999268

  Condition:   Diabetes Mellitus, Type 2
  Interventions:   Behavioral: I-START;   Behavioral: Standard Insulin Administration Education
  Sponsor:   University of Pittsburgh
  Not yet recruiting
• The Impact of a Home-based Pulmonary Telerehabilitation Program in Acute Exacerbations of COPD

  NCT03997513

  Condition:   Pulmonary Disease, Chronic Obstructive
  Intervention:   Behavioral: Pulmonary Telerehabilitation
  Sponsor:   VA Office of Research and Development
  Not yet recruiting
• Prevention of Unmitigated Chemotherapy-induced Emesis

  NCT03996863

  Conditions:   Chemotherapy-induced Nausea and Vomiting;   Nausea Post Chemotherapy
  Interventions:   Device: Otoband;   Device: Placebo device
  Sponsors:   Otolith Labs;   Drexel University College of Medicine
  Not yet recruiting
• Medication Adherence and Outcomes Among Patients in United States With HIV

  NCT03995745

  Conditions:   Human Immunodeficiency Virus;   Medication Adherence
  Intervention:   Behavioral: Medication adherence and financial incentives
  Sponsors:   University of Pennsylvania;   Drexel University
  Recruiting
• Effect of rTMS on Anxiety

  NCT03993509

  Conditions:   Anxiety;   Fear;   Anxiety and Fear
  Intervention:   Device: rTMS to the right dlPFC
  Sponsor:   University of Pennsylvania
  Not yet recruiting
• A Study of a Values-Based Intervention to Promote Weight Loss

  NCT03991676

  Conditions:   Obesity;   Weight Loss
  Intervention:   Behavioral: Values-Based Behavioral Treatment
  Sponsor:   Drexel University
  Recruiting
• Vessel Wall MR Imaging to Explore Sex-Differences of Intracranial Arterial Wall Changes After Suspected Stroke

  NCT03990545

  Conditions:   Intracranial Atherosclerosis;   Acute Stroke;   Transient Ischemic Attack
  Intervention:  
  Sponsor:   University of Pennsylvania
  Recruiting
• Prospective Use of Awake Endoscopy for Inspire Activation

  NCT03990298

  Condition:   Obstructive Sleep Apnea
  Intervention:   Diagnostic Test: Awake endoscopy
  Sponsor:   University of Pennsylvania
  Enrolling by invitation
• [18F]Fluciclovine in Post-treatment Glioblastoma ( Axumin )

  NCT03990285

  Condition:   Glioma Glioblastoma Multiforme
  Intervention:   Drug: Axumin, Intravenous Solution
  Sponsors:   Seyed Ali Nabavizadeh, MD;   Blue Earth Diagnostics
  Recruiting
• Biological Effects of Quercetin in COPD

  NCT03989271

  Condition:   Chronic Obstructive Pulmonary Disease
  Intervention:   Drug: Quercetin
  Sponsors:   Temple University;   National Institutes of Health (NIH);   Quercegen Pharmaceuticals;   National Center for Complementary and Integrative Health (NCCIH)
  Not yet recruiting
• Improving Self-care of Heart Failure Caregivers

  NCT03988621

  Condition:   Heart Failure
  Intervention:   Behavioral: ViCCY
  Sponsor:   University of Pennsylvania
  Not yet recruiting
• Open Label Pharmaco- Magnetic Resonance Spectrography (MRS) Study of Clavulanic Acid

  NCT03986762

  Conditions:   Cocaine Dependence, in Remission;   Cocaine Abuse, in Remission;   Cocaine-Related Disorders
  Intervention:   Drug: Clavulanic Acid
  Sponsors:   Temple University;   National Institute on Drug Abuse (NIDA)
  Recruiting
• Mindfulness-based Dance/Movement Therapy for Chronic Low Back Pain

  NCT03986489

  Condition:   Chronic Low-back Pain
  Interventions:   Behavioral: Mindfulness-based dance/movement therapy (M-DMT);   Behavioral: Chronic pain social support group
  Sponsors:   Drexel University;   National Center for Complementary and Integrative Health (NCCIH);   Stony Brook University
  Recruiting
• Specialty Medical Homes to Improve Outcomes for Patients With IBD and Behavioral Health Conditions

  NCT03985800

  Conditions:   Inflammatory Bowel Disease;   Behavioral Symptoms
  Interventions:   Other: TEAM;   Other: TECH
  Sponsors:   University of Pittsburgh;   Mount Sinai Hospital, New York;   The Cleveland Clinic;   Patient-Centered Outcomes Research Institute
  Recruiting
• Machine-Generated Mortality Estimates and Nudges to Promote Advance Care Planning Discussion Among Cancer Patients

  NCT03984773

  Condition:   Oncology
  Intervention:   Behavioral: Nudge
  Sponsor:   University of Pennsylvania
  Enrolling by invitation
• Heart Failure Self-care Mobile Application to Reduce Readmissions Trial

  NCT03982017

  Condition:   Heart Failure
  Interventions:   Other: Mobile Health Technology Platform;   Other: Usual care
  Sponsors:   University of Pittsburgh;   Agency for Healthcare Research and Quality (AHRQ)
  Not yet recruiting
• Nurse AMIE: Addressing Metastatic Individuals Everyday

  NCT03975621

  Condition:   Metastatic Breast Cancer
  Intervention:   Behavioral: Supportive Care
  Sponsor:   Milton S. Hershey Medical Center
  Recruiting
• Understanding Trauma Nightmares Using In-Home Measurement

  NCT03974503

  Conditions:   Nightmares;   Stress Disorders, Post-Traumatic;   Actigraphy;   Respiratory Sinus Arrhythmia;   Veterans
  Interventions:   Behavioral: Exposure, Relaxation, and Rescripting Therapy;   Behavioral: Sleep and Nightmare Management
  Sponsor:   VA Office of Research and Development
  Not yet recruiting
• Penn Microbiome Therapy for Recurrent Clostridium Difficile Infection

  NCT03973697

  Condition:   Recurrent Clostridium Difficile Infection
  Interventions:   Drug: Penn Microbiome Therapy - 001;   Drug: Penn Microbiome Therapy - 002;   Drug: Penn Microbiome Therapy - 003
  Sponsor:   University of Pennsylvania
  Not yet recruiting
• Impact of Serious Pediatric Illness on Parent and Sibling Health

  NCT03971344

  Conditions:   Family Members of: Newborns Extremely Premature;   Family Members of: New Pediatric Oncology Patients;   Family Members of: Critical Congenital Heart Defect Patients;   Family Members of: Children Severe Neurological Impairment
  Intervention:  
  Sponsors:   Children's Hospital of Philadelphia;   Cigna Foundation
  Enrolling by invitation
• The Effect of Self-Forgiveness on Self-Stigma in Addiction.

  NCT03971097

  Conditions:   Substance Use Disorders;   Opiate Dependence;   Opiate Withdrawal Syndrome;   Opioid-use Disorder;   Alcohol Withdrawal;   Alcohol Abuse;   Alcohol Use Disorder;   Cocaine Abuse;   Cocaine Use Disorder;   Cocaine Withdrawal;   Benzodiazepine Abuse;   Benzodiazepine Dependence;   Substance Abuse;   Heroin Overdoses;   Heroin Withdrawal;   Heroin Abuse
  Interventions:   Behavioral: Six Step Model of Self-Forgiveness;   Behavioral: Treatment as Usual (TAU)
  Sponsors:   University of Pittsburgh;   Indiana University of Pennsylvania
  Not yet recruiting
• PMT for Severe-CDI

  NCT03970200

  Conditions:   Severe Clostridium Difficile Infection;   Severe-Complicated/Fulminant Clostridium Difficile Infection
  Interventions:   Drug: Penn Microbiome Therapy - 001;   Drug: Penn Microbiome Therapy - 002;   Drug: Penn Microbiome Therapy - 003;   Drug: Antibiotics
  Sponsor:   University of Pennsylvania
  Not yet recruiting
• Abemaciclib in Patients With Oligodendroglioma

  NCT03969706

  Condition:   Oligodendroglioma, Adult
  Intervention:   Drug: Abemaciclib 200 MG
  Sponsor:   University of Pennsylvania
  Recruiting
• Telehealth Intervention in Cirrhotics

  NCT03969186

  Conditions:   Cirrhosis, Liver;   Liver Diseases
  Intervention:   Behavioral: Intervention
  Sponsor:   University of Pennsylvania
  Recruiting
• MOVE UP Lifestyle Intervention for Caregivers

  NCT03967912

  Conditions:   Body Weight;   Healthy Diet;   Physical Activity;   Health Behavior;   Healthy Aging
  Intervention:   Behavioral: MOVE UP
  Sponsors:   University of Pittsburgh;   Centers for Disease Control and Prevention
  Not yet recruiting
• Assessing the Impact of myHealth Rewards Enrollment Emails

  NCT03965754

  Conditions:   Health Promotion;   Wellness Programs
  Interventions:   Behavioral: Social norms;   Behavioral: Loss framing;   Behavioral: Email reminder
  Sponsor:   Geisinger Clinic
  Active, not recruiting
• Developing an Injury Prevention Simulation Game to Better Engage Parents in Services -Home Safety Hero

  NCT03965377

  Condition:   Parenting
  Intervention:   Behavioral: Home Safety Hero Computer Game
  Sponsor:   Penn State University
  Enrolling by invitation
• Priming With tDCS: Expanding the Window of Recovery in Chronic Stroke

  NCT03964467

  Condition:   Upper Extremity Paresis
  Intervention:   Device: transcranial direct current stimulation
  Sponsors:   University of the Sciences in Philadelphia;   Chapman University;   Moss Rehabilitation Research Institute;   Thomas Jefferson University
  Recruiting
• Sustainability of MOVE UP Lifestyle Intervention

  NCT03963830

  Conditions:   Body Weight;   Diet, Healthy;   Physical Disability
  Intervention:   Behavioral: MOVE UP
  Sponsors:   University of Pittsburgh;   Centers for Disease Control and Prevention
  Recruiting
• Molecular Basis of Pediatric Liver Cancer

  NCT03959800

  Conditions:   Childhood Liver Cancer;   Liver Malignant Tumors;   Embryonal Sarcoma of Liver (Disorder);   Hepatoblastoma;   Hepatocellular Carcinoma;   Rhabdoid Tumor of Liver
  Intervention:  
  Sponsor:   University of Pittsburgh
  Recruiting
• Cardiac Cath Lab Staff Radiation Exposure

  NCT03959072

  Conditions:   Coronary Artery Disease;   Chronic Total Occlusion of Coronary Artery;   Percutaneous Coronary Intervention
  Interventions:   Device: Robotic CTO PCI;   Procedure: Conventional (Manual) CTO PCI
  Sponsor:   Corindus Inc.
  Not yet recruiting
• Palliative Care Consultations in the Skilled Nursing Facility (SNF) Setting

  NCT03958552

  Conditions:   Palliative Care;   Advance Care Planning;   Skilled Nursing Facilities
  Intervention:   Other: Palliative Care Consultation
  Sponsor:   University of Pennsylvania
  Enrolling by invitation
• A Study Based on Medical Records That Looks at the Characteristics of Idiopathic Pulmonary Fibrosis Patients Grouped by the Type of Medication They Are Taking

  NCT03958071

  Condition:   Idiopathic Pulmonary Fibrosis
  Interventions:   Drug: Nintedanib;   Drug: Pirfenidone;   Other: Untreated Cohort
  Sponsor:   Boehringer Ingelheim
  Completed
• Hyperthermia and Olaparib in Treating Breast Cancer Patients With Chest Wall Recurrences

  NCT03955640

  Conditions:   Metastatic Malignant Neoplasm in the Chest Wall;   Recurrent Breast Carcinoma
  Interventions:   Drug: Olaparib;   Procedure: Hyperthermia Treatment;   Other: Questionnaire Administration;   Other: Quality-of-Life Assessment
  Sponsors:   Thomas Jefferson University;   AstraZeneca
  Recruiting
• POC SPLA2-IIA as a Biomarker for Sepsis and Septic Shock

  NCT03953404

  Condition:   Sepsis
  Intervention:   Diagnostic Test: SPLA2-IIA
  Sponsor:   St. Luke's Hospital, Pennsylvania
  Recruiting
• HeartPhone Cancer Survivors Trial 2019

  NCT03953326

  Conditions:   Breast Cancer;   Leukemia;   Lymphoma
  Interventions:   Behavioral: HeartPhone app;   Drug: Acetylcholine;   Drug: Sodium Nitroprusside;   Drug: L-Arginine, N2-((4-Methylphenyl)Sulfonyl)-, Methyl Ester
  Sponsor:   Penn State University
  Recruiting
• Reducing Sedentary Behavior to Improve Sleep: an Ancillary Study to the RESET BP Clinical Trial

  NCT03946228

  Conditions:   Sleep;   Obstructive Sleep Apnea;   Insomnia
  Intervention:   Behavioral: Behavioral Intervention
  Sponsors:   University of Pittsburgh;   National Heart, Lung, and Blood Institute (NHLBI)
  Enrolling by invitation
• Healthy Mom Zone: A Gestational Weight Gain Management Intervention

  NCT03945266

  Conditions:   Overweight and Obesity;   Physical Activity;   Weight Change, Body;   Eating Behavior
  Interventions:   Behavioral: Intervention group;   Behavioral: Control group
  Sponsors:   Penn State University;   National Heart, Lung, and Blood Institute (NHLBI);   Arizona State University
  Completed
• Virtual Reality-enhanced Exercise and Education in Cardiac Rehabilitation

  NCT03945201

  Conditions:   Adherence, Patient;   Motivation;   Satisfaction
  Interventions:   Other: Virtual walking trails;   Other: Standard of care
  Sponsor:   Thomas Jefferson University
  Completed
• Genetics and Shared Decision Making in Improving Care for Patients With Stage IVA-C Non-small Cell Lung Cancer

  NCT03944265

  Conditions:   Activating ALK Gene Mutation Negative;   Activating EGFR Gene Mutation Negative;   Activating ROS1 Gene Mutation Negative;   Health Care Provider;   Lung Non-Small Cell Carcinoma;   Stage IV Lung Cancer AJCC v8;   Stage IVA Lung Cancer AJCC v8;   Stage IVB Lung Cancer AJCC v8
  Interventions:   Other: Counseling;   Other: Questionnaire Administration;   Other: Medical Chart Review
  Sponsor:   Thomas Jefferson University
  Recruiting
• Development and Initial Tests of Reward Re-Training: A Novel Treatment For Reward Dysfunction

  NCT03942874

  Conditions:   Binge Eating;   Binge-Eating Disorder;   Bulimia Nervosa
  Intervention:   Behavioral: Group Reward Retraining
  Sponsor:   Drexel University
  Enrolling by invitation
• Using Digital Health, Financial Incentives, and Community Health Worker Support to Change Health Behavior

  NCT03939793

  Condition:   Diabetes Mellitus
  Interventions:   Behavioral: IMPaCT Community Health Worker;   Behavioral: Digital health monitoring with financial incentives;   Other: Usual Care
  Sponsors:   University of Pennsylvania;   The Commonwealth Fund
  Recruiting
• NGS for Non-unions

  NCT03937310

  Condition:   Nonunion of Fracture
  Intervention:   Diagnostic Test: Next-generation sequencing of swabs collected during surgery
  Sponsor:   Rothman Institute Orthopaedics
  Enrolling by invitation
• Efficacy and Safety Trial of ADU-S100 and Anti-PD1 in Head and Neck Cancer

  NCT03937141

  Conditions:   Metastatic Head and Neck Cancer;   Recurrent Head and Neck Cancer
  Intervention:   Drug: ADU-S100
  Sponsor:   Aduro Biotech, Inc.
  Recruiting
• Study of Humidified Air to Improve Mucociliary Clearance (MCC) in COPD

  NCT03935932

  Condition:   COPD
  Intervention:   Device: nasal delivery of heated and humidified air
  Sponsors:   Frank C Sciurba;   Fisher and Paykel Healthcare
  Recruiting
• Adoptive Transfer of Tumor Infiltrating Lymphocytes for Advanced Solid Cancers

  NCT03935893

  Conditions:   Gastric Cancer;   Colorectal Cancer;   Pancreatic Cancer;   Sarcoma;   Mesothelioma;   Neuroendocrine Tumors;   Squamous Cell Cancer;   Merkel Cell Carcinoma;   Mismatch Repair Deficiency;   Microsatellite Instability
  Interventions:   Biological: Tumor Infiltrating Lymphocytes (TIL);   Drug: Fludarabine + Cyclophosphamide combination
  Sponsor:   Udai Kammula
  Recruiting
• Evaluating an Alternative Clinical Genetics Cancer Care Deliver Model

  NCT03934606

  Conditions:   Pancreas Cancer;   Prostate Cancer;   Hereditary Cancer;   Genetic Predisposition to Disease
  Intervention:   Behavioral: Genetic testing for hereditary predisposition
  Sponsor:   University of Pennsylvania
  Recruiting
• A Study for the Assessment of the Benefits of a Novel Mesh Nebulizer in the Treatment of Patients With Stable COPD

  NCT03933462

  Condition:   COPD
  Interventions:   Device: InnoSpire Go;   Device: Jet Nebulizer
  Sponsor:   Philips Respironics
  Recruiting
• Circulating miRNA in Primary Hyperparathyroidism

  NCT03931109

  Conditions:   Primary Hyperparathyroidism;   Osteoporosis, Postmenopausal
  Intervention:  
  Sponsor:   University of Pennsylvania
  Recruiting
• Coping Together After Breast Cancer

  NCT03930797

  Condition:   Breast Cancer
  Interventions:   Behavioral: Intimacy Enhancement;   Behavioral: Living Healthy Together
  Sponsors:   Fox Chase Cancer Center;   National Cancer Institute (NCI)
  Recruiting
• Proactive Outreach and Shared Decision Making in Improving Lung Cancer Screening Rates in Primary Care Patients

  NCT03929926

  Condition:   Lung Cancer
  Interventions:   Other: Best Practice;   Behavioral: Cancer Educational Materials;   Other: Behavioral, Psychological or Informational Intervention;   Other: Counseling
  Sponsor:   Thomas Jefferson University
  Recruiting
• Contrast Enhanced Mammography in Diagnosing Patients With Suspicious Breast Findings

  NCT03929783

  Condition:   Breast Neoplasms
  Intervention:   Procedure: Contrast Enhanced Digital Mammography
  Sponsor:   Thomas Jefferson University
  Not yet recruiting
• Management Of Pain After Cesarean Trial

  NCT03929640

  Conditions:   Pain, Postoperative;   Opioid Use
  Interventions:   Drug: Acetaminophen;   Drug: Placebo;   Drug: Ibuprofen
  Sponsor:   Milton S. Hershey Medical Center
  Recruiting
• Shifting Perspectives: Enhancing Outcomes in Anorexia Nervosa With CRT

  NCT03928028

  Condition:   Anorexia Nervosa
  Interventions:   Behavioral: Cognitive Remediation Therapy;   Behavioral: Family Based Treatment
  Sponsor:   Children's Hospital of Philadelphia
  Recruiting
• First - In - Man Study to Assess the Safety and Feasibility of The Bashir™ Endovascular Catheter for the Treatment of Acute Pulmonary Embolism

  NCT03927508

  Condition:   Pulmonary Embolism
  Interventions:   Drug: r-tPA;   Device: The Bashir™ Endovascular Catheter
  Sponsor:   Thrombolex, Inc.
  Recruiting
• Variations in Palatability and Portion Size of Vegetables on Meal Intake of Preschool Children

  NCT03926065

  Condition:   Feeding Behavior
  Interventions:   Other: Plain Vegetables Served in 100% Portion Size;   Other: Plain Vegetables Served in 200% Portion Size;   Other: Enhanced Vegetables Served in 100% Portion Size;   Other: Enhanced Vegetables Served in 200% Portion Size
  Sponsors:   Penn State University;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
  Recruiting
• Evaluation of TXA Prior to Surgery in the Geriatric Hip Fracture Population

  NCT03923959

  Condition:   Hip Fractures
  Interventions:   Drug: Tranexamic Acid Injectable Solution;   Other: Placebo
  Sponsor:   Lancaster General Hospital
  Not yet recruiting
• Fixed Inclination Humeral Cut

  NCT03922763

  Condition:   Shoulder Osteoarthritis
  Interventions:   Procedure: Anatomical cut;   Procedure: Cutting guide
  Sponsor:   Rothman Institute Orthopaedics
  Enrolling by invitation
• Telehealth Following Orthopaedic Procedures

  NCT03922737

  Condition:   Post-Op Complication
  Interventions:   Procedure: In-person office visit;   Procedure: Teleheath visit
  Sponsor:   Rothman Institute Orthopaedics
  Enrolling by invitation
• JAK Inhibitor Treatment in AGS

  NCT03921554

  Condition:   Aicardi Goutieres Syndrome
  Intervention:   Drug: Baricitinib
  Sponsors:   Adeline Vanderver, MD;   Eli Lilly and Company
  Recruiting
• Augmented Reality Enhanced Surgery: Use of Holographic Technology in Cranial and Spinal Surgery

  NCT03921385

  Condition:   Surgery
  Intervention:  
  Sponsor:   University of Pennsylvania
  Active, not recruiting
• TEMPO Study: Trimethoprim-Sulfamethoxazole in Granulomatosis With Polyangiitis

  NCT03919435

  Conditions:   Granulomatosis With Polyangiitis;   Wegener Granulomatosis
  Intervention:   Drug: Trimethoprim Sulfamethoxazole
  Sponsor:   University of Pennsylvania
  Recruiting
• The Effects of Guarding on the Outcomes of the Six Minute Walk Test

  NCT03916952

  Conditions:   Functional Capacity;   Physical Activity;   Rehabilitation
  Intervention:   Diagnostic Test: Six Minute Walk Test
  Sponsor:   Concordia University, St. Paul
  Completed
• Virtual Reality in Plastic Surgery: Pain Control and Augmented Satisfaction

  NCT03914937

  Conditions:   Pain;   Anxiety
  Interventions:   Other: Virtual reality;   Other: Music
  Sponsor:   The Guthrie Clinic
  Recruiting
• Ostomy Telehealth Training Cancer Survivors

  NCT03913715

  Conditions:   Ostomy;   Quality of Life;   Telehealth
  Intervention:   Behavioral: Ostomy Self-Management Training
  Sponsors:   University of Pennsylvania;   National Cancer Institute (NCI)
  Not yet recruiting
• Facilitating Optimal Routines in Aging

  NCT03913637

  Condition:   Strategy Training
  Interventions:   Behavioral: Strategy Training;   Other: Enhanced Usual Care
  Sponsors:   University of Pittsburgh;   National Institutes of Health (NIH);   National Institute on Aging (NIA)
  Recruiting
• Neuromotor Prosthetic to Treat Stroke-Related Paresis

  NCT03913286

  Conditions:   Stroke, Complication;   Stroke;   Stroke Sequelae;   Hemiparesis;   Arm Paralysis
  Intervention:   Device: Cortimo
  Sponsor:   Thomas Jefferson University
  Recruiting
• Comparative Effectiveness of Social Physical Play and Traditional Exercise Programming

  NCT03913078

  Conditions:   Group Fitness (Traditional);   Group Fitness (Game Play-based)
  Interventions:   Behavioral: Group Fitness;   Behavioral: PlayFit
  Sponsors:   Milton S. Hershey Medical Center;   National Institutes of Health (NIH)
  Recruiting
• Opioid Taper Study

  NCT03912298

  Condition:   Chronic Pain
  Intervention:   Other: Opioid Taper Pain perception
  Sponsors:   University of Pennsylvania;   National Institute on Drug Abuse (NIDA);   National Institutes of Health (NIH)
  Recruiting
• Whole Exome Sequencing and Whole Genome Sequencing for Non-immune Fetal/Neonatal Hydrops

  NCT03911531

  Conditions:   Non-immune Fetal Hydrops;   Non-Immune Hydrops in Neonate;   Genetic Disorders
  Interventions:   Diagnostic Test: Whole Exome Sequencing;   Diagnostic Test: Whole Genome Sequencing
  Sponsor:   Thomas Jefferson University
  Recruiting
• Evaluation of SmartSleep Technology for Improving the Efficiency and Restorative Quality of Sleep in Healthy Adults

  NCT03911154

  Condition:   Sleep
  Intervention:   Device: Philips SmartSleep Technology
  Sponsors:   University of Pennsylvania;   National Aeronautics and Space Administration (NASA);   Philips Healthcare;   University of Wisconsin, Madison
  Recruiting
• Behavioral Economic Approaches to Increase Physical Activity Among Patients With Elevated Risk for Cardiovascular Disease

  NCT03911141

  Condition:   Atherosclerotic Cardiovascular Disease
  Interventions:   Behavioral: Gamification;   Behavioral: Financial
  Sponsor:   University of Pennsylvania
  Recruiting
• A Collection of Case Studies in Infants With UCD to Evaluate Infant Growth and the Safety of a New Medical Food for UCD

  NCT03911089

  Conditions:   Urea Cycle Disorder;   Inborn Errors of Metabolism
  Intervention:   Other: UCD Anamix Infant
  Sponsor:   Nutricia Research
  Recruiting
• Positive Parenting Program in Foster Care

  NCT03910491

  Conditions:   Child Behavior Problem;   Child Behavior Disorders;   Parenting
  Intervention:   Behavioral: PriCARE
  Sponsors:   Children's Hospital of Philadelphia;   Ray E. Helfer Society
  Recruiting
• Wheelchair Maintenance Training Program

  NCT03909061

  Condition:   Remote Maintenance Training Program
  Intervention:   Behavioral: Wheelchair Maintenance Training
  Sponsors:   University of Pittsburgh;   Department of Health and Human Services
  Recruiting
• Rapid Initiation of Drug Treatment Engagement

  NCT03908437

  Conditions:   Opioid-use Disorder;   Overdose
  Intervention:   Drug: buprenorphine/naloxone
  Sponsors:   University of Pennsylvania;   Prevention Point Philadelphia;   Public Health Management Corporation;   Philadelphia Department of Public Health
  Recruiting
• Random Assignment of Intervention Messages for Developing Personalized Decision Rules to Promote Physical Activity

  NCT03907683

  Condition:   Cardiovascular Risk Factor
  Intervention:   Behavioral: Short Message with Text and Optional Image
  Sponsor:   Penn State University
  Recruiting
• SIS Evaluation of the MRI Defined Subthalamic Nucleus*

  NCT03907319

  Condition:   Deep Brain Stimulation
  Intervention:   Device: SIS System
  Sponsor:   Surgical Information Sciences Inc.
  Enrolling by invitation
• A Study of Abemaciclib in Combination With Sunitinib in Metastatic Renal Cell Carcinoma

  NCT03905889

  Condition:   Renal Cell Carcinoma Metastatic
  Interventions:   Drug: Abemaciclib;   Drug: Sunitinib
  Sponsors:   Milton S. Hershey Medical Center;   Eli Lilly and Company
  Recruiting
• Exercise Therapy in Radiation Therapy

  NCT03905356

  Condition:   Metastatic Cancer
  Intervention:   Behavioral: Exercise Therapy
  Sponsor:   Milton S. Hershey Medical Center
  Not yet recruiting
• miRNA and Myokines in Patients With PAH

  NCT03905083

  Condition:   Pulmonary Arterial Hypertension
  Intervention:   Other: Exercise Rehab
  Sponsor:   University of Pittsburgh
  Recruiting
• ASSIST: Treatment for Childhood Apraxia of Speech

  NCT03903120

  Condition:   Childhood Apraxia of Speech
  Intervention:   Behavioral: ASSIST
  Sponsor:   Temple University
  Recruiting
• Study of ST266 Given by Intranasal Delivery in Subjects With Ocular Hypertension

  NCT03901781

  Condition:   Ocular Hypertension
  Intervention:   Combination Product: ST266 via Intranasal Delivery
  Sponsor:   Noveome Biotherapeutics, formerly Stemnion
  Not yet recruiting
• Evaluation of Flortaucipir PET Signal and Cognitive Change in Early Alzheimer's Disease

  NCT03901105

  Condition:   Alzheimer Disease
  Intervention:   Drug: flortaucipir F18
  Sponsor:   Avid Radiopharmaceuticals
  Completed
• A Reader Study to Assess Accuracy and Reliability of Flortaucipir F 18 PET Scan Interpretation

  NCT03901092

  Condition:   Alzheimer Disease
  Intervention:   Drug: flortaucipir F 18
  Sponsor:   Avid Radiopharmaceuticals
  Completed
• Effects of Heating on Exercise Pressor Reflex in Peripheral Artery Disease: Exercise Ability

  NCT03900832

  Condition:   PAD
  Interventions:   Other: Without Heating;   Other: Warm Bath;   Other: Neutral Bath;   Other: Heating Suit;   Other: Lower limb warm water immersion;   Other: Gardner walking protocol
  Sponsor:   Milton S. Hershey Medical Center
  Recruiting
• Plan and Pledge, HIV Self-testing in South Africa

  NCT03898557

  Condition:   Human Immunodeficiency Virus
  Interventions:   Behavioral: Provision of HIV self-test with Commitment and planning prompts;   Behavioral: Provision of HIV self-test
  Sponsors:   University of Pennsylvania;   Wits Reproductive Health and HIV Institute
  Active, not recruiting
• Pneumatic Technology for Powered Mobility Devices

  NCT03898362

  Condition:   Disability
  Interventions:   Other: pneumatically powered wheelchair or scooter;   Device: battery powered wheelchair or scooter
  Sponsor:   VA Office of Research and Development
  Not yet recruiting
• Perioperative Glucocorticoid Administration in the Treatment of Adult Distal Radius Fractures

  NCT03898154

  Condition:   Distal Radius Fracture
  Interventions:   Drug: Dexamethasone;   Drug: Methylprednisolone
  Sponsor:   C. Liam Dwyer
  Recruiting
• Strategic Targeting for Optimal Prevention of Cancer

  NCT03897374

  Condition:   Early Detection of Cancer
  Intervention:   Diagnostic Test: Genetic Testing
  Sponsor:   ClinLogic LLC
  Recruiting
• Ketamine for Refractory Chronic Migraine: a Pilot Study

  NCT03896256

  Condition:   Migraine Headache With Intractable Migraine
  Intervention:   Drug: ketamine infusion
  Sponsor:   Thomas Jefferson University
  Enrolling by invitation
• Brief Stresses Experimental Study

  NCT03893617

  Conditions:   DNA Damage;   Psychological Stress
  Interventions:   Drug: Propranolol;   Drug: Placebo oral capsule;   Behavioral: Acute stress task;   Behavioral: No stress task
  Sponsors:   Dana Bovbjerg;   National Cancer Institute (NCI)
  Recruiting
• Towards Predicting the Analgesic Response to Ibuprofen Following Third-molar Extraction

  NCT03893175

  Conditions:   Impacted Third Molar Tooth;   Pain, Acute
  Interventions:   Drug: Ibuprofen;   Drug: Acetaminophen;   Drug: Placebo;   Drug: Oxycodone
  Sponsor:   University of Pennsylvania
  Recruiting
• Neuromuscular Electrical Stimulation for Jaw-closing Dystonia

  NCT03889704

  Condition:   Muscle Dystonia
  Intervention:   Device: Omnistim® FX²
  Sponsor:   Edward Burton
  Recruiting
• Evaluating Performance of Invu Versus IUPC in Monitoring of Pregnant Subjects With Uterine Contractions.

  NCT03889405

  Condition:   Healthy, Pregnant Women
  Intervention:   Device: Invu
  Sponsor:   Nuvo-Group, Ltd.
  Recruiting
• Study of Brain Cools Device in Patients Resuscitated From Cardiac Arrest

  NCT03889340

  Condition:   Cardiac Arrest With Successful Resuscitation
  Intervention:   Device: IQool
  Sponsors:   Adam Frisch;   BrainCool
  Recruiting
• Vestibular Physical Therapy for People With Alzheimer Disease

  NCT03887923

  Conditions:   Vestibular Diseases;   Alzheimer Disease;   Cognitive Impairment
  Intervention:   Behavioral: Vestibular Physical Therapy
  Sponsors:   University of Pittsburgh;   Johns Hopkins University
  Recruiting
• Impact of Prehabilitation in Oncology Via Exercise- Bone Marrow Transplant

  NCT03886909

  Conditions:   Hematopoietic Stem Cell Transplant;   Hematologic Diseases;   Physical Activity;   Prehabilitation
  Interventions:   Behavioral: Exercise;   Behavioral: Prehabilitation Education
  Sponsor:   Milton S. Hershey Medical Center
  Recruiting
• Pharmacokinetic (PK) and Pharmacodynamics (PD) Study of Ilera Specific Products

  NCT03886753

  Conditions:   ALS;   Autism Spectrum Disorder;   Cancer;   Spasticity, Muscle;   Dyskinetic Syndrome;   Epilepsy;   Glaucoma;   Huntington Disease;   Inflammatory Bowel Disease (IBD);   Multiple Sclerosis;   Neuropathy;   Opioid Use;   Parkinson Disease;   HIV/AIDS;   Ptsd;   Intractable Pain;   Sickle Cell Disease;   Terminal Illness
  Interventions:   Other: Registry;   Other: PK microsampling of blood
  Sponsors:   Children's Hospital of Philadelphia;   Ilera Healthcare
  Recruiting
• Doravirine, Rifapentine and Isoniazid Interaction

  NCT03886701

  Conditions:   Latent Tuberculosis;   Human Immunodeficiency Virus;   Rifamycins Causing Adverse Effects in Therapeutic Use;   Drug Interaction Potentiation
  Interventions:   Drug: Doravirine (DOR);   Drug: Rifapentine (RPT);   Drug: Isoniazid (INH)
  Sponsors:   Walter K. Kraft;   Merck Sharp & Dohme Corp.
  Active, not recruiting
• The Influence of Satiation Measures on the Portion Size Effect

  NCT03886428

  Condition:   Feeding Behavior
  Interventions:   Other: 100% portion size;   Other: 125% portion size;   Other: 150% portion size;   Other: 175% portion size
  Sponsors:   Penn State University;   Jenny Craig, Inc.
  Recruiting
• Efficacy of a Transcranial Vibrating System for Mitigation of Migraine Associated Vertigo

  NCT03886012

  Conditions:   Dizziness;   Nausea;   Headache;   Confusion
  Interventions:   Device: Otoband;   Device: Otoband sham
  Sponsor:   Otolith Labs
  Recruiting
• Vascepa to Accelerate Lipoprotein Uptake and Elimination

  NCT03885661

  Conditions:   Lipid Disorder;   Triglycerides High;   Dyslipidemias
  Intervention:   Drug: Icosapent Ethyl 1000 MG [Vascepa]
  Sponsors:   University of Pennsylvania;   Amarin Pharma Inc.
  Active, not recruiting
• Impact of Behavioral Treatment of Insomnia on Nighttime Urine Production

  NCT03883724

  Conditions:   Sleep Fragmentation;   Poor Quality Sleep;   Nocturia;   Nocturnal Enuresis
  Interventions:   Behavioral: Brief behavioral treatment of insomnia (BBTI);   Behavioral: Information-only control (IC)
  Sponsors:   University of Pittsburgh;   National Institute on Aging (NIA)
  Recruiting
• Stromal Vascular Fraction From Lipoaspirate to Treatment of Chronic Non-healing Wound

  NCT03882983

  Condition:   Chronic Wounds
  Intervention:   Drug: Antria Cell Preparation Process
  Sponsor:   Antria
  Recruiting
• Evaluation of a Letter Intervention Promoting a Plant-based Diet

  NCT03880838

  Conditions:   Cardiovascular Diseases;   Diabetes Mellitus;   Obesity
  Interventions:   Behavioral: Personal testimonial;   Behavioral: Forks Over Knives Documentary;   Behavioral: Commitment nudge;   Behavioral: Prevention nudge
  Sponsor:   Geisinger Clinic
  Active, not recruiting
• Exparel Use in Bilateral TAP Blocks for Postoperative Pain Control

  NCT03878888

  Conditions:   Postoperative Pain;   Surgery;   Anesthesia, Local
  Intervention:   Drug: Exparel 266 MG Per 20 ML Injection
  Sponsor:   St. Luke's Hospital, Pennsylvania
  Recruiting
• Trigger Thumb Randomized Controlled Trial

  NCT03873480

  Condition:   Trigger Thumb
  Intervention:   Procedure: Administration of Marcaine without Epinephrine prior to the start of surgery
  Sponsor:   Children's Hospital of Philadelphia
  Recruiting
• Offloading Device for Post Surgical Foot Procedures

  NCT03873207

  Condition:   Plantar Fascitis
  Interventions:   Device: PopSole™ offloading device;   Device: padded insole
  Sponsors:   Jeffrey A. Gusenoff, MD;   University of Pittsburgh
  Not yet recruiting
• Increasing Childhood Sleep Duration in the Primary Care Setting

  NCT03870282

  Condition:   Childhood Sleep Promotion
  Intervention:   Behavioral: Sleep Extension
  Sponsor:   Children's Hospital of Philadelphia
  Recruiting
• Physical Exercise and Bladder Training Program for Urinary Incontinence

  NCT03869918

  Condition:   Urinary Incontinence
  Intervention:   Other: Exercise Program
  Sponsor:   University of Pennsylvania
  Completed
• Cerebral Cortical Influences on Autonomic Function

  NCT03869372

  Conditions:   Healthy Subjects;   Functional Dyspepsia;   Irritable Bowel Syndrome
  Intervention:   Device: rTMS
  Sponsors:   David Levinthal;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
  Recruiting
• Exercises for Improving Soft Palate and Eustachian Tube Function in Children With Ear Tubes With or Without Cleft Palate

  NCT03868891

  Conditions:   Cleft Palate;   Tube Disorders Eustachian;   Velopharyngeal Incompetence Due to Cleft Palate;   Velopharyngeal Insufficiency
  Interventions:   Device: EarPopper;   Device: EMST150
  Sponsors:   Noel Jabbour;   National Institute on Deafness and Other Communication Disorders (NIDCD)
  Recruiting
• The Natural History of Injury-Related Disuse Osteopenia

  NCT03868085

  Condition:   Osteopenia
  Intervention:   Diagnostic Test: dual energy x-ray absorptiometry
  Sponsor:   Milton S. Hershey Medical Center
  Enrolling by invitation
• Weight Management Intervention for Youth and Young Adults With Autism Spectrum Disorder

  NCT03865719

  Condition:   Autism Spectrum Disorder
  Intervention:   Behavioral: Healthy Habits for Life
  Sponsors:   University of Pittsburgh;   Massachusetts General Hospital
  Recruiting
• Post-op Ketamine Study

  NCT03865550

  Condition:   Osteo Arthritis Knee
  Interventions:   Drug: Isotonic saline;   Drug: Ketamine Injectable Solution
  Sponsor:   Rothman Institute Orthopaedics
  Active, not recruiting
• Comparing Ropivacaine Adductor Canal Blockade by Surgeon Versus Anesthesiologist

  NCT03864588

  Conditions:   Pain, Postoperative;   Satisfaction
  Intervention:   Drug: Ropivacaine
  Sponsors:   Rothman Institute Orthopaedics;   Sharpe-Strumia Research Foundation
  Enrolling by invitation
• Inositol Supplementation to Treat PCOS (INSUPP-PCOS)

  NCT03864068

  Conditions:   Polycystic Ovary Syndrome;   Anovulation;   Hyperandrogenism;   Insulin Resistance;   Glucose Intolerance;   Metabolic Complication
  Interventions:   Other: Placebo;   Drug: Inositol powder
  Sponsors:   Milton S. Hershey Medical Center;   National Center for Complementary and Integrative Health (NCCIH)
  Not yet recruiting
• [18F] F-GLN by PET/CT in Breast Cancer

  NCT03863457

  Condition:   Breast Cancer
  Intervention:   Drug: Fluoroglutamine [18F]F-GLN
  Sponsor:   University of Pennsylvania
  Recruiting
• REMAP Trial for Optimizing Surgical Outcomes at UPMC

  NCT03861767

  Condition:   Aging
  Interventions:   Drug: Metformin ER;   Drug: Placebo
  Sponsors:   Derek C. Angus, MD, MPH;   University of Pittsburgh Medical Center;   Berry Consultants
  Recruiting
• Auriculotherapy for Surgical Pain

  NCT03860259

  Conditions:   Acute Pain;   Surgery;   Shoulder Pain
  Interventions:   Device: Auriculotherapy cryopuncture device without nitrogen gas;   Device: Auriculotherapy cryopuncture device with nitrogen gas
  Sponsor:   Jacques E. Chelly
  Not yet recruiting
• Use of Digital Tomosynthesis for Detection and Case Management of Scaphoid and Distal Radius Fractures: A VolumeRAD Data Collection Study

  NCT03856450

  Conditions:   Distal Radius Fracture;   Scaphoid Fracture
  Interventions:   Device: DTS;   Device: X-ray;   Device: MRI or CT
  Sponsor:   GE Healthcare
  Recruiting
• Microfracture vs. Microfracture and BMAC for Osteochondral Lesions of the Talus

  NCT03856021

  Condition:   Osteochondral Lesion of Talus
  Interventions:   Procedure: Microfracture with Bone Marrow Aspirate Concentrate;   Procedure: Microfracture
  Sponsor:   Rothman Institute Orthopaedics
  Enrolling by invitation
• Healthy, Immunized Communities Study

  NCT03854734

  Conditions:   Vaccine Hesitancy;   Communicable Diseases in Children
  Interventions:   Behavioral: Community Event;   Behavioral: Educational Material
  Sponsors:   Milton S. Hershey Medical Center;   Merck Sharp & Dohme Corp.
  Recruiting
• Tubomanometry and EarPopper Devices for Eustachian Tube Function Testing

  NCT03850197

  Condition:   Eustachian Tube Dysfunction
  Interventions:   Device: EarPopper;   Device: Tympanometry;   Device: Tubomanometry
  Sponsors:   University of Pittsburgh;   National Institute on Deafness and Other Communication Disorders (NIDCD)
  Recruiting
• Poor Sleep and Inflammation in HIV-Infected Adults

  NCT03848325

  Conditions:   HIV-1-infection;   Sleep Deprivation;   Inflammation
  Intervention:   Behavioral: Sleep deprivation
  Sponsors:   University of Pittsburgh;   National Heart, Lung, and Blood Institute (NHLBI)
  Not yet recruiting
• Imaging of Primary or Recurrent Breast Cancer With 18F-FluorThanatrace PET/CT

  NCT03846167

  Condition:   Breast Cancer
  Intervention:   Drug: Imaging Drug FluorThanatrace (FTT)
  Sponsor:   University of Pennsylvania
  Recruiting
• Development of an Algorithm That Predicts Hypoventilation Due to an Opioid Overdose

  NCT03845699

  Conditions:   Drug Overdose;   Opioid-Related Disorders
  Intervention:   Device: Diagnostic algorithms that detects/predicts hypoventilation
  Sponsors:   RTM Vital Signs, LLC;   Thomas Jefferson University
  Recruiting
• Diet and Exercise Interventions to Treat Claudication

  NCT03845036

  Conditions:   Claudication;   Peripheral Artery Disease
  Interventions:   Behavioral: DASH Diet plus Home-Based Exercise;   Behavioral: Home-Based Exercise
  Sponsor:   Milton S. Hershey Medical Center
  Not yet recruiting
• Transition of Diabetes Care From Pediatric to Adult Healthcare Providers.

  NCT03844126

  Condition:   Transition
  Intervention:   Other: Transition classes
  Sponsor:   Milton S. Hershey Medical Center
  Recruiting
• Commensal Oral Microbiota in H&N Cancer

  NCT03843554

  Condition:   Head and Neck Cancer
  Interventions:   Other: Standard of Care Oral Hygiene;   Procedure: Oral mucosal deterging and dental prophylaxis
  Sponsor:   Abramson Cancer Center of the University of Pennsylvania
  Not yet recruiting
• Exercise, Brain, and Cardiovascular Health

  NCT03841669

  Condition:   Cardiovascular Diseases
  Interventions:   Behavioral: Aerobic Exercise Group;   Behavioral: Physical Activity & Health Information Group
  Sponsors:   University of Pittsburgh;   National Institutes of Health (NIH);   National Heart, Lung, and Blood Institute (NHLBI)
  Recruiting
• Pulse Wave Velocity, Tacrolimus Time in Therapeutic Range and CV in African American Kidney Transplants

  NCT03841097

  Condition:   Kidney Transplant; Complications
  Interventions:   Drug: Extended Release Tacrolimus Tablets;   Drug: Immediate Release Tacrolimus Capsule
  Sponsors:   Roy D. Bloom, MD;   Veloxis Pharmaceuticals
  Not yet recruiting
• Blood Spot Self-administered Test and Assay

  NCT03840824

  Conditions:   Dysfunction; Endocrine;   Effects of Chemotherapy;   Premature Ovarian Failure
  Intervention:  
  Sponsor:   University of Pennsylvania
  Completed
• Phase II Study of the Combination of Mitoxantrone, Etoposide and Gemtuzumab Ozogamicin (MEGO) for Patients With Acute Myeloid Leukemia Refractory to Initial Standard Induction Therapy

  NCT03839446

  Condition:   Acute Myeloid Leukemia
  Intervention:   Drug: mitoxantrone + etoposide + gemtuzumab ozogamicin
  Sponsor:   Michael Boyiadzis
  Recruiting
• Patient Preparedness for Pelvic Organ Prolapse Surgery

  NCT03836365

  Conditions:   Pelvic Organ Prolapse;   Patient Preparedness
  Interventions:   Other: Preoperative counseling office visit;   Other: Preoperative counseling phone call
  Sponsors:   University of Pittsburgh;   University of Pittsburgh Medical Center
  Recruiting
• A Pragmatic Trial To Determine the Benefit of Exercise Incentives and Corticosteroid Injections in Osteoarthritis of the Knee

  NCT03835910

  Condition:   Osteoarthritis of the Knee
  Interventions:   Behavioral: Social Incentives and Gamification to Promote Exercise;   Procedure: Corticosteroid Injection given in A-B order;   Behavioral: No Social Incentive applied;   Procedure: Corticosteroid Injection given in B-A order
  Sponsor:   VA Office of Research and Development
  Recruiting
• QOL Assessment in Cancer Survivors Integrated Into Routine Clinical Care

  NCT03835052

  Condition:   Cancer
  Intervention:  
  Sponsor:   Geisinger Clinic
  Recruiting
• NSS-2-BRIDGE Study for Total Knee and Hip Arthroplasties

  NCT03834142

  Conditions:   Acute Pain;   Arthropathy of Knee;   Arthropathy of Hip
  Intervention:   Device: NSS-2 Bridge
  Sponsor:   Jacques E. Chelly
  Recruiting
• Cortical Biomarkers of Hand Function and Recovery After Injury

  NCT03833518

  Conditions:   Stroke;   Spinal Cord Injuries
  Interventions:   Other: Rehabilitation using motorized glove for stroke and spinal cord injury;   Other: Functional MRI for stroke and spinal cord injury;   Other: Transcranial magnetic stimulation (TMS) for stroke and spinal cord injury
  Sponsors:   VA Pittsburgh Healthcare System;   University of Pittsburgh
  Not yet recruiting
• Comparative Effectiveness of Financial Incentives and Nudges to Reduce Cellphone Use While Driving Among UBI Auto Policy Holders

  NCT03833219

  Condition:   Automobile Accident
  Interventions:   Behavioral: Weekly feedback;   Behavioral: End of intervention period incentive;   Behavioral: Loss-framed weekly incentive
  Sponsors:   University of Pennsylvania;   U.S. Department of Transportation Federal Highway Administration
  Enrolling by invitation
• Kidney Coordinated Health Management Partnership

  NCT03832595

  Condition:   Chronic Kidney Diseases
  Interventions:   Other: Intervention Arm;   Other: Usual Care
  Sponsors:   University of Pittsburgh;   Vanderbilt University Medical Center;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
  Enrolling by invitation
• Team-based Ergonomics Educational Model for Workplace WELLNESS Improvement: A Pilot Study

  NCT03831737

  Conditions:   MSDs;   Muscle Pain
  Intervention:   Behavioral: stretching exercises
  Sponsor:   Milton S. Hershey Medical Center
  Active, not recruiting
• A Study of INO-A002 in Healthy Dengue Virus-naive Adults

  NCT03831503

  Condition:   Healthy Volunteers
  Interventions:   Biological: INO-A002;   Device: CELLECTRA® 2000;   Device: Dengue Fever Antibodies (IgG)
  Sponsors:   University of Pennsylvania;   Inovio Pharmaceuticals
  Recruiting
• Pharmacologically-based Strategies for Buprenorphine Treatment During Pregnancy

  NCT03831113

  Conditions:   Opiate Addiction;   Pregnancy
  Interventions:   Drug: Buprenorphine: Magnitude Group;   Drug: Buprenorphine: Interval Group;   Drug: Buprenorphine: Dosing Group
  Sponsors:   Steve N. Caritis, MD;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
  Recruiting
• NSS-Bridge Device for Post-Cesarean Delivery Pain

  NCT03830307

  Conditions:   Acute Pain;   Cesarean Delivery
  Intervention:   Device: NSS-2-Bridge
  Sponsor:   Grace Lim, MD, MS
  Completed
• Lidocaine Administration During Flexible Bronchoscopy and Endobronchial Ultrasound

  NCT03829618

  Conditions:   Bronchiectasis Adult;   Mediastinal Lymphadenopathy;   Pneumonia;   Chest--Diseases;   Infiltrates;   Bronchopulmonary Disease;   Cancer, Lung
  Interventions:   Drug: Topical lidocaine;   Drug: Nebuliser solution;   Drug: Nebuliser Suspension
  Sponsor:   Milton S. Hershey Medical Center
  Recruiting
• Comprehensive CBT (Cognitive Behavioral Therapy) Via reSET App

  NCT03826966

  Conditions:   Addiction;   Opioid-use Disorder
  Intervention:   Device: reSET
  Sponsors:   Milton S. Hershey Medical Center;   Columbia University;   Research Foundation for Mental Hygiene, Inc.
  Recruiting
• Bone Healing Accelerant Versus Standard of Care for Open Tibia Fractures

  NCT03826784

  Condition:   Tibial Fractures
  Intervention:   Combination Product: BHA
  Sponsor:   Carmell Therapeutics Corporation
  Not yet recruiting
• Melatonin Effects on Sleep and Circadian Rhythm in Youth and Young Adults With At-risk Symptoms

  NCT03826563

  Conditions:   Psychosis;   Sleep
  Interventions:   Drug: oral melatonin tablets (NatureMade brand);   Other: Placebo
  Sponsors:   Children's Hospital of Philadelphia;   University of Pennsylvania;   Brain and Behavior Research Foundation (NARSAD Young Investigator Award, Grant Number 26742)
  Recruiting
• Almond Butter and Fasting Glucose

  NCT03826472

  Condition:   Type2 Diabetes
  Intervention:   Other: Almond Butter
  Sponsor:   Penn State University
  Recruiting
• Immunotherapy SBRT Sensitization of the Programmed Death-1 (PD-1) Effect

  NCT03825510

  Conditions:   Metastatic Nonsmall Cell Lung Cancer;   Non Small Cell Lung Cancer
  Intervention:   Radiation: Stereotactic Body Radiotherapy
  Sponsors:   Crozer-Keystone Health System;   Saint Peter's University Hospital, New Brunswick, NJ;   Community Medical Center, Toms River, NJ
  Recruiting
• Patient-centered and Efficacious Advance Care Planning in Cancer: the PEACe Comparative Effectiveness Trial

  NCT03824158

  Conditions:   Cancer;   Advance Care Planning
  Interventions:   Behavioral: In-person, facilitated advance care planning;   Behavioral: Web-based advance care planning
  Sponsors:   University of Pittsburgh;   National Cancer Institute (NCI)
  Enrolling by invitation