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Ohio

• A Pilot Study to Assess the Accuracy of Blood Pressure Assessment by the Omron HeartGuide Smartwatch

  NCT03986281

  Conditions:   Hypertension;   Cardiac Disease;   Surgery
  Interventions:   Other: Omron Wearable Device;   Other: Standard Arterial Line
  Sponsor:   The Cleveland Clinic
  Recruiting
• A Single Session Pain Psychology Class for Spine Surgery Patients

  NCT03985436

  Condition:   Lumbar; Injury
  Intervention:   Behavioral: Trek for Surgical Success
  Sponsor:   Sara Davin, PsyD, MPH
  Enrolling by invitation
• Daily Living Skills Intervention for 9th and 10th Graders With Autism Spectrum Disorders

  NCT03984513

  Condition:   Autism Spectrum Disorder
  Interventions:   Behavioral: Surviving and Thriving in the Real World;   Behavioral: Program for the Education and Enrichment of Relational Skills
  Sponsors:   Children's Hospital Medical Center, Cincinnati;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
  Recruiting
• A Program to Increase Sickle Cell Trait Knowledge Among Parent of Infants Identified in Newborn Screening

  NCT03984500

  Condition:   Sickle Cell Trait
  Intervention:   Other: Education
  Sponsors:   Susan Creary;   National Institutes of Health (NIH);   National Heart, Lung, and Blood Institute (NHLBI)
  Not yet recruiting
• Daily Living Skills Intervention for Adolescents With Autism Spectrum Disorder

  NCT03984487

  Condition:   Autism Spectrum Disorder
  Interventions:   Behavioral: Surviving and Thriving in the Real World;   Behavioral: Program for the Education and Enrichment of Relational Skills
  Sponsors:   Children's Hospital Medical Center, Cincinnati;   United States Department of Defense
  Recruiting
• IPACK Versus Popliteal Sciatic Nerve Block in ACL Reconstruction

  NCT03983941

  Condition:   Anterior Cruciate Ligament Tear
  Intervention:   Drug: Ropivacaine injection
  Sponsor:   Sujana Dontukurthy
  Not yet recruiting
• Efficacy and Application of the Alfred SmartBag System After Ileostomy Creation in Colorectal Surgery: A Pilot Study

  NCT03982875

  Conditions:   Ileostomy - Stoma;   Ileostomy; Complications
  Intervention:   Device: Alfred SmartBag
  Sponsors:   11 Heath and Technologies Limited;   The Cleveland Clinic
  Recruiting
• Innovations to Prevent Relapse Among Low-income African American Smokers

  NCT03982576

  Condition:   Smoking Cessation
  Interventions:   Other: Nicotine replacement therapy (NRT);   Behavioral: CS-CBT intervention;   Behavioral: Path2Quit;   Behavioral: Relapse prevention program;   Behavioral: SmokefreeTXT
  Sponsor:   Case Comprehensive Cancer Center
  Not yet recruiting
• Dietary Supplementation in Heart Failure

  NCT03980574

  Condition:   Heart Failure
  Intervention:   Dietary Supplement: R Drink
  Sponsors:   Ohio State University;   Vascular Scientific, LLC
  Recruiting
• A Pilot Study of KPL-914 in Recurrent Pericarditis

  NCT03980522

  Condition:   Recurrent Pericarditis
  Intervention:   Drug: KPL-914
  Sponsor:   Kiniksa Pharmaceuticals, Ltd.
  Completed
• Trial of Blood Flow Restriction Plus Physical Therapy vs. Physical Therapy Alone for Lateral Epicondylitis

  NCT03978897

  Condition:   Lateral Epicondylitis
  Interventions:   Device: Blood flow restriction tourniquet;   Other: Evidence based physical/occupational therapy
  Sponsor:   Akron General Medical Center
  Not yet recruiting
• Dual-benefits of Aerobic and Resistance Training

  NCT03978572

  Conditions:   Sarcopenia;   Aging;   Disability Physical
  Interventions:   Behavioral: Resistance Training;   Behavioral: Moderate-Intensity Continuous Cycling;   Behavioral: High-Intensity Interval Cycling
  Sponsors:   Ohio University;   American Heart Association
  Recruiting
• Dabrafenib, Trametinib, and IMRT in Treating Patients With BRAF Mutated Anaplastic Thyroid Cancer

  NCT03975231

  Conditions:   BRAF NP_004324.2:p.V600E;   BRAF V600K Mutation Present;   Thyroid Gland Anaplastic Carcinoma
  Interventions:   Drug: Dabrafenib;   Radiation: Intensity-Modulated Radiation Therapy;   Drug: Trametinib
  Sponsors:   Manisha Shah;   National Cancer Institute (NCI)
  Not yet recruiting
• Parastomal Hernia Repair Utilizing the Retromuscular Sugarbaker Versus Keyhole Mesh Techniques

  NCT03972553

  Condition:   Parastomal Hernia
  Interventions:   Procedure: Sugarbaker technique for repairing parastomal hernia;   Procedure: Keyhole technique for repairing parastomal hernia
  Sponsor:   The Cleveland Clinic
  Recruiting
• A Problem Solving Intervention for Post-ICU Cognitive Impairment in Older Adults

  NCT03972384

  Conditions:   Critical Illness;   Mechanical Ventilation Complication;   Delirium;   Cognitive Impairment
  Intervention:   Behavioral: Post-ICU Problem Solving
  Sponsor:   Ohio State University
  Not yet recruiting
• Meta-analysis of Stannous Fluoride and the Effects on Gingival Health

  NCT03970759

  Condition:   Gingivitis
  Interventions:   Drug: Stannous Fluoride Dentifrice;   Drug: Positive control dentifrice;   Drug: Negative control dentifrice
  Sponsor:   Procter and Gamble
  Completed
• Evaluation of Step-Based Care for Individuals at Clinical High Risk for Psychosis

  NCT03970005

  Condition:   Prodromal Schizophrenia
  Intervention:   Behavioral: Step-Based Care Model
  Sponsors:   Ohio State University;   Substance Abuse and Mental Health Services Administration (SAMHSA)
  Enrolling by invitation
• Oral Ketorolac for Arthroscopic Rotator Cuff Repair

  NCT03967847

  Conditions:   Rotator Cuff Tear;   Postoperative Pain
  Intervention:   Drug: Ketorolac
  Sponsor:   University Hospitals Cleveland Medical Center
  Recruiting
• TRPV2 Agonists in the Fontan Circulation

  NCT03965351

  Condition:   Fontan
  Intervention:   Drug: Probenecid
  Sponsors:   Children's Hospital Medical Center, Cincinnati;   American Heart Association
  Recruiting
• Kidney Fibrosis and MRI

  NCT03964948

  Condition:   Kidney Diseases
  Intervention:   Diagnostic Test: Kidney MRI
  Sponsor:   Children's Hospital Medical Center, Cincinnati
  Recruiting
• Effect of One-lung Ventilation on BIS Values

  NCT03962036

  Conditions:   Surgery;   Thoracic
  Intervention:   Device: Bispectral index monitor
  Sponsor:   Christopher McKee
  Not yet recruiting
• Cancer Activity and Lifestyle Measurement Study

  NCT03961685

  Condition:   Breast Cancer
  Intervention:  
  Sponsor:   Ohio State University
  Recruiting
• Glycemic Characterization and Pancreatic Imaging Correlates in Cystic Fibrosis

  NCT03961516

  Conditions:   Cystic Fibrosis;   Cystic Fibrosis-related Diabetes;   Cystic Fibrosis Liver Disease;   Pancreatic Steatosis;   Hepatic Steatosis
  Interventions:   Device: Frequently Sampled Oral Glucose Tolerance Test and CGM;   Radiation: MRI Pancreas and Liver
  Sponsor:   University Hospitals Cleveland Medical Center
  Recruiting
• Gadoxetate Sodium Enhanced MRI as a Biomarker for Aggressive Prostate Cancer

  NCT03960788

  Conditions:   Cancer of the Prostate;   Castration-resistant Prostate Cancer
  Intervention:   Drug: Gadoxetate Sodium
  Sponsor:   University of Cincinnati
  Recruiting
• Photodynamic Therapy and Microvesicles

  NCT03960125

  Conditions:   Photodynamic Therapy;   Microvesicle Particle
  Interventions:   Device: Photodynamic Therapy;   Drug: 4% Imipramine;   Drug: Base Cream
  Sponsor:   Jeffrey B. Travers, MD, PhD
  Not yet recruiting
• Behavioral Economics and Adherence in Teens (BEAT!)

  NCT03958331

  Conditions:   Epilepsy;   Adherence, Medication
  Interventions:   Behavioral: Automated Digital Reminders;   Behavioral: Individualized Adherence Feedback Report;   Behavioral: Individual Adherence Feedback Report with Social Norms
  Sponsors:   Children's Hospital Medical Center, Cincinnati;   National Institute of Nursing Research (NINR);   Nationwide Children's Hospital
  Not yet recruiting
• OT Via Telehealth (ASD and ADHD)

  NCT03957993

  Conditions:   Autism Spectrum Disorder;   Attention Deficit Hyperactivity Disorder
  Interventions:   Other: Occupational Therapy via Telehealth;   Other: Standard of Care Occupational Therapy
  Sponsor:   Children's Hospital Medical Center, Cincinnati
  Recruiting
• Remote Access: Cortical Visual Impairment

  NCT03957980

  Condition:   Cortical Visual Impairment
  Intervention:   Other: Occupational therapy
  Sponsor:   Children's Hospital Medical Center, Cincinnati
  Completed
• CPX-351 Therapy for MDS After Hypomethylating Agent Failure

  NCT03957876

  Condition:   Myelodysplastic Syndrome (MDS)
  Intervention:   Drug: CPX-351
  Sponsor:   Case Comprehensive Cancer Center
  Not yet recruiting
• Cardiovascular Outcomes in Bariatric Surgery Patients With Type 2 Diabetes

  NCT03955952

  Conditions:   Obesity;   Type2 Diabetes;   Bariatric Surgery Candidate
  Intervention:   Procedure: Bariatric Surgery
  Sponsor:   The Cleveland Clinic
  Enrolling by invitation
• AveXis Managed Access Program Cohort for Access to AVXS-101

  NCT03955679

  Condition:   Spinal Muscular Atrophy
  Intervention:   Genetic: AVXS-101
  Sponsors:   United BioSource Corporation;   AveXis, Inc.
  Approved for marketing
• Healthy Relationships Training Study: A Comparison of Interventions to Reduce Dating Violence on College Campuses

  NCT03950128

  Condition:   Dating Violence
  Interventions:   Behavioral: Mindfulness-Based Skills Training (MBST);   Behavioral: Psychoeducational
  Sponsor:   Kent State University
  Completed
• Free Flap Breast Reconstruction Using Virtual Surgical Planning and 3-D Modeling

  NCT03949491

  Condition:   Breast Reconstruction
  Intervention:   Procedure: 3D medical models
  Sponsor:   Case Comprehensive Cancer Center
  Not yet recruiting
• Ultrasound Assessment of the Inferior Vena Cava in Children

  NCT03948282

  Condition:   Surgery
  Intervention:  
  Sponsor:   Alok Moharir
  Not yet recruiting
• Efficacy of Baricitinib In Treatment of Delayed-Type Hypersensitivity Versus Irritant Skin Reactions in Healthy Adult Male Subjects

  NCT03945760

  Condition:   Allergic Contact Dermatitis
  Interventions:   Drug: Baricitinib;   Drug: Placebo
  Sponsor:   Wright State Physicians
  Not yet recruiting
• Ibrutinib and Venetoclax in Treating Patients With Chronic Lymphocytic Leukemia After Ibrutinib Resistance

  NCT03943342

  Conditions:   Chronic Lymphocytic Leukemia;   Loss of Chromosome 17p
  Interventions:   Drug: Ibrutinib;   Drug: Venetoclax
  Sponsors:   Kerry Rogers;   National Cancer Institute (NCI);   Janssen Research & Development, LLC
  Not yet recruiting
• Proton Accelerated Partial Breast Irradiation

  NCT03940248

  Condition:   Breast Cancer
  Intervention:   Radiation: Proton Accelerated Partial Breast Irradiation
  Sponsor:   University of Cincinnati
  Enrolling by invitation
• Preemptive Infusion of Donor Lymphocytes Depleted of TCR + T Cells + CD19+ B Cells Following ASCT

  NCT03939585

  Conditions:   Allogeneic Stem Cell Transplant Candidate;   Acute Myeloid/Lymphoblastic Leukemia;   Myelodysplastic Syndrome;   Myeloproliferative Neoplasm;   Lymphoproliferative Disorders
  Intervention:   Biological: Cellular therapy product
  Sponsor:   Case Comprehensive Cancer Center
  Not yet recruiting
• A Study to Evaluate ENT-01 for the Treatment of Parkinson's Disease Dementia

  NCT03938922

  Conditions:   Parkinson Disease;   Dementia
  Interventions:   Drug: Active Investigational Treatment ENT-01;   Drug: Placebo Treatment
  Sponsor:   Enterin Inc.
  Recruiting
• Randomized Control Trial Comparing Transfascial Suture for Mesh Fixation to No Mesh Fixation

  NCT03938688

  Conditions:   Ventral Hernia;   Incisional Hernia
  Intervention:   Procedure: Mesh placement with Transfascial Sutures
  Sponsor:   The Cleveland Clinic
  Not yet recruiting
• Evaluation of the Precision and Sensitivity of Tilmanocept Uptake Value (TUV) on Tc 99m Tilmanocept Planar Imaging

  NCT03938636

  Condition:   Rheumatoid Arthritis
  Intervention:   Drug: TC99m-tilmanocept
  Sponsor:   Navidea Biopharmaceuticals
  Recruiting
• The Renin-Angiotensin-Aldosterone System in Adiposity, Blood Pressure and Glucose in African Americans

  NCT03938389

  Conditions:   PreDiabetes;   Impaired Glucose Tolerance;   Obesity;   Blood Pressure
  Interventions:   Drug: Sacubitril-Valsartan Tab 97-103 MG;   Drug: Valsartan 160mg;   Drug: Placebo Oral Tablet
  Sponsors:   Ohio State University;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
  Not yet recruiting
• Motivational Interviewing and Vaccine Hesitancy in Children

  NCT03934008

  Condition:   Vaccine Hesitancy
  Intervention:   Other: MOtivational interviewing Tool to Improve Vaccine AdherencE (MOTIVE)
  Sponsors:   Cedarville University;   Merck Investigator Studies Program;   Rocking Horse Community Health Center
  Recruiting
• Study Assessing Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MGTA-145 in Healthy Volunteers as a Single Agent or in Combination With Plerixafor

  NCT03932864

  Condition:   Healthy Volunteers
  Interventions:   Biological: MGTA-145;   Biological: plerixafor;   Biological: Placebo
  Sponsor:   Magenta Therapeutics, Inc.
  Recruiting
• Gene Expression Changes In Young and Geriatric Skin

  NCT03932162

  Conditions:   UVB Phototherapy Burn;   Insulin-like Growth Factor 1;   Aging
  Interventions:   Drug: Insulin-Like Growth Factor 1;   Other: No Insulin-Lie Growth Factor 1
  Sponsor:   Jeffrey B. Travers, MD, PhD
  Not yet recruiting
• Collaborating to Implement Cross-System Interventions in Child Welfare and Substance Use

  NCT03931005

  Conditions:   Substance Use;   Implementation;   Child Maltreatment;   System Fragmentation
  Interventions:   Other: Collaboration Decision Support Guide;   Other: General Collaboration Support
  Sponsor:   Ohio State University
  Not yet recruiting
• 18F-Fluciclovine PET to Distinguish Tumor Progression From Radiation Necrosis

  NCT03930173

  Condition:   Secondary Malignant Neoplasm of Brain and Cerebral Meninges
  Interventions:   Drug: 18F-fluciclovine;   Device: PET/CT of the brain
  Sponsor:   Case Comprehensive Cancer Center
  Recruiting
• Liposomal Bupivacaine Versus Interscalene Nerve Block

  NCT03929146

  Condition:   Pain, Postoperative
  Interventions:   Drug: Exparel;   Procedure: Interscalene Nerve Block
  Sponsor:   University of Cincinnati
  Recruiting
• Feasibility of a Culturally-Specific Video Text Cessation Intervention With AA Quitline Callers

  NCT03927976

  Condition:   Tobacco Use Cessation
  Intervention:   Behavioral: Path2Quit - culturally specific text message intervention
  Sponsor:   Case Comprehensive Cancer Center
  Not yet recruiting
• GSNOR Phenotyping/GSNO Challenge

  NCT03926741

  Conditions:   Asthma;   Healthy Volunteers
  Intervention:   Drug: GSNO
  Sponsors:   James Reynolds;   University Hospitals Cleveland Medical Center;   Case Western Reserve University;   National Heart, Lung, and Blood Institute (NHLBI)
  Recruiting
• Screening for Systemic Amyloidosis Via the Ligamentum Flavum

  NCT03923920

  Conditions:   Amyloid;   Amyloidosis;   Spinal Stenosis;   Transthyretin Amyloidosis;   Primary Amyloidosis of Light Chain Type
  Intervention:   Procedure: Biopsy
  Sponsor:   The Cleveland Clinic
  Recruiting
• Study of the Safety and Efficacy of DPI-386 Nasal Gel on Ocean-Going Vessels

  NCT03920644

  Conditions:   Prevention of Nausea Associated With Motion Sickness;   Treatment of Nausea Associated With Motion Sickness
  Interventions:   Drug: Scopolamine Transdermal Patch [Transderm Scop];   Drug: Scopolamine;   Drug: Placebo Patch;   Drug: Placebo Gel
  Sponsor:   Naval Aeromedical Research Unit, Dayton
  Recruiting
• A Study of the Use of AirXpanders AeroForm in Patients Undergoing Post-Mastectomy Radiation Therapy

  NCT03918317

  Condition:   Breast Cancer
  Intervention:   Device: AirXpanders AeroFormtissue expander
  Sponsor:   Case Comprehensive Cancer Center
  Not yet recruiting
• A Clinical Study of the Eztetic Dental Implant System

  NCT03917927

  Condition:   Edentulous Jaw
  Intervention:   Device: Eztetic dental implant
  Sponsor:   Zimmer Biomet
  Recruiting
• Older Adult Effectiveness of 2 Treatments

  NCT03916926

  Condition:   Dental Caries
  Interventions:   Device: A "simple medical strategy" consisting of silver diamine fluoride (SDF);   Device: B "typical dental strategy" consisting of atraumatic restorative treatment (ART) with glass ionomer cement + Fluoride varnish (FV)
  Sponsors:   Case Western Reserve University;   Patient-Centered Outcomes Research Institute
  Not yet recruiting
• Registry and Screening Tool to Identify Children With Asthma Likely to Benefit From Home Assessment and Remediation

  NCT03916237

  Conditions:   Asthma;   Pediatric ALL;   School Health Services;   Registries;   Medical Informatics;   Home Visits;   Housing Problems;   Social Determinants of Health;   Healthcare Disparity;   Health Status Disparity
  Interventions:   Other: Home assessment;   Other: Home remediation;   Other: Referral to Medical Legal Partnership;   Other: Asthma SDH screening tool
  Sponsors:   MetroHealth Medical Center;   Cleveland Metropolitan School District;   Environmental Health Watch;   Legal Aid Society of Cleveland
  Not yet recruiting
• Fuzzy AI Using VR for Collision Prevention

  NCT03915119

  Condition:   Injuries
  Intervention:   Other: GFT AI training
  Sponsor:   Children's Hospital Medical Center, Cincinnati
  Active, not recruiting
• Fontan Associated Liver Disease

  NCT03914196

  Condition:   Fontans
  Intervention:   Diagnostic Test: Liver Stiffness Ultrasound
  Sponsor:   Children's Hospital Medical Center, Cincinnati
  Recruiting
• Effects of Neuromuscular Training on EEG Adaptations in Young Athletes

  NCT03913975

  Condition:   Brain Concussion
  Intervention:   Other: Neuromuscular training
  Sponsor:   Children's Hospital Medical Center, Cincinnati
  Completed
• Hemoglobin Desaturation in Sickle Cell Disease

  NCT03908385

  Condition:   Sickle Cell Disease
  Intervention:  
  Sponsor:   University Hospitals Cleveland Medical Center
  Recruiting
• Liposomal Bupivacaine After Cesarean Delivery

  NCT03907813

  Conditions:   Pain, Postoperative;   Opioid Use
  Interventions:   Drug: Exparel;   Other: Saline infiltration
  Sponsor:   Wright State University
  Not yet recruiting
• Advance Care Planning GuideTailored for Primary Care Patients

  NCT03906773

  Conditions:   Advance Care Planning;   Chronic Disease;   Communication Research
  Intervention:   Other: Patient Centered Medical Home Based Electronic Framework for Advance Care Planning
  Sponsor:   Ohio State University
  Completed
• Effectiveness of Fractionated Laser Resurfacing to Protect Geriatric Skin From Actinic Neoplasia

  NCT03906253

  Conditions:   Actinic Keratoses;   Aging;   Non-Melanoma Skin Cancer
  Intervention:   Device: Fractionated Laser Resurfacing
  Sponsor:   Jeffrey B. Travers, MD, PhD
  Recruiting
• Identification of microRNAs Involved in Cerebral Collateral Regulation

  NCT03905434

  Condition:   Cerebrovascular Disorders
  Intervention:   Genetic: miRNA sampling
  Sponsor:   Ohio State University
  Recruiting
• Defining the Operating Characteristics of NIRS in the Diagnosis of Pediatric Traumatic Intracranial Hemorrhage

  NCT03905031

  Conditions:   Craniocerebral Injuries;   Head Injuries;   Head Injury, Minor;   Head Trauma;   Traumatic Brain Injury;   Traumatic Brain Hemorrhage;   Hematoma of Head;   Intracranial Hemorrhages
  Intervention:   Device: InfraScanner 2000
  Sponsor:   Dayton Children's Hospital
  Enrolling by invitation
• Testing the Safety and Tolerability of CX-4945 in Patients With Recurrent Medulloblastoma Who May or May Not Have Surgery

  NCT03904862

  Condition:   Medulloblastoma, Childhood
  Intervention:   Drug: CX 4945
  Sponsors:   Pediatric Brain Tumor Consortium;   St. Jude Children's Research Hospital;   National Cancer Institute (NCI)
  Not yet recruiting
• Post-partum Non-pharmacologic Pain Management

  NCT03903172

  Conditions:   Pain Management;   Vaginal Delivery
  Intervention:   Device: Abdominal binder
  Sponsor:   Wright State University
  Not yet recruiting
• Optical Treatment of Migraines Using the Avulux™ Optical Filter in the Form of Spectacle Lenses.

  NCT03902496

  Condition:   Migraine
  Interventions:   Other: HIT-6 Questionnaire;   Device: Avulux Spectacles;   Device: Sham Spectacles
  Sponsor:   Avulux, Inc.
  Recruiting
• A Protein-sparing Modified Fast for Children and Adolescents With Severe Obesity (PSMF)

  NCT03899311

  Condition:   Obesity, Childhood
  Intervention:   Other: protein-sparing modified fast diet
  Sponsor:   Ihuoma Eneli
  Completed
• An Early Feasibility Study of the ReHAB System

  NCT03898804

  Condition:   Tetraplegia
  Intervention:   Device: BCI and FES
  Sponsor:   Jonathan Miller, MD
  Not yet recruiting
• The Effect of Psychologically Informed Education in Adolescents With Anterior Knee Pain

  NCT03897907

  Conditions:   Patellofemoral Pain Syndrome;   Anterior Knee Pain Syndrome
  Interventions:   Other: Psychologically Informed Education Video;   Other: Anatomy Education Video
  Sponsor:   Nationwide Children's Hospital
  Recruiting
• Safety & Immunogenicity Study of Ad5 Based Oral Norovirus Vaccines

  NCT03897309

  Condition:   Norovirus Infection
  Interventions:   Biological: VXA-G1.1-NN;   Biological: VXA-G2.4-NS;   Biological: Placebo Tablets
  Sponsor:   Vaxart
  Recruiting
• Efficacy and Safety of Tildrakizumab in the Treatment of Scalp Psoriasi

  NCT03897088

  Condition:   Scalp Psoriasis
  Interventions:   Drug: Tildrakizumab;   Drug: Placebo
  Sponsor:   Sun Pharma Global FZE
  Recruiting
• Teaching Parents Reiki for Their Adolescents Receiving Palliative Care

  NCT03896165

  Conditions:   Palliative Care;   Chronic Disease
  Intervention:   Other: Reiki
  Sponsors:   Ohio State University;   Akron Children's Hospital
  Not yet recruiting
• Supermarket and Web-Based Intervention Targeting Nutrition (SuperWIN) for Cardiovascular Risk Reduction

  NCT03895580

  Conditions:   Obesity;   Hypertension;   Hyperlipidemias;   Diet Modification
  Interventions:   Other: In-store POP education;   Other: Online POP education
  Sponsors:   University of Cincinnati;   The Kroger Company;   Children's Hospital Medical Center, Cincinnati
  Recruiting
• Use of Lumbar Motion Monitor to Predict Response to Radiofrequency Ablation After Medial Branch Diagnostic Blocks

  NCT03894319

  Condition:   Back Pain
  Intervention:  
  Sponsor:   Ohio State University
  Recruiting
• Database Of Clinical Data For Individuals With Variants In The IRF2BPL Gene

  NCT03892798

  Conditions:   Neurodevelopmental Regression, Seizures, Autism and Developmental Delay (NEDAMSS);   Autism Spectrum Disorder;   Movement Disorders;   Seizures;   Dystonia
  Intervention:   Other: No interventions are planned
  Sponsor:   Children's Hospital Medical Center, Cincinnati
  Recruiting
• Duvelisib and Nivolumab in Treating Patients With Richter Syndrome or Transformed Follicular Lymphoma

  NCT03892044

  Conditions:   Chronic Lymphocytic Leukemia;   Recurrent Diffuse Large B-Cell Lymphoma;   Refractory Diffuse Large B-Cell Lymphoma;   Richter Syndrome;   Small Lymphocytic Lymphoma;   Transformed Chronic Lymphocytic Leukemia to Diffuse Large B-Cell Lymphoma;   Transformed Follicular Lymphoma to Diffuse Large B-Cell Lymphoma;   Transformed Small Lymphocytic Lymphoma to Diffuse Large B-Cell Lymphoma
  Interventions:   Drug: Duvelisib;   Biological: Nivolumab
  Sponsors:   Jennifer Woyach;   National Cancer Institute (NCI)
  Not yet recruiting
• Intestinal Microbiome Composition in Infants With Biliary Atresia (BA)

  NCT03890536

  Conditions:   Biliary Atresia;   Intrahepatic Cholestases;   Normal Controls
  Intervention:  
  Sponsors:   Children's Hospital Medical Center, Cincinnati;   Wuhan Union Hospital, China
  Not yet recruiting
• Phase IB Metformin, Digoxin, Simvastatin in Solid Tumors

  NCT03889795

  Conditions:   Advanced Pancreatic Cancer;   Advanced Solid Tumor
  Interventions:   Drug: Metformin;   Drug: Simvastatin;   Drug: Digoxin
  Sponsor:   John Nemunaitis, MD
  Not yet recruiting
• Study of Ketorolac Versus Opioid for Pain After Endoscopy

  NCT03888144

  Conditions:   Kidney Calculi;   Ureteral Calculi
  Interventions:   Drug: Oxycodone;   Drug: Ketorolac
  Sponsor:   The Cleveland Clinic
  Recruiting
• A Systematic Oral Care Program in Post-Mechanically Ventilated, Post-Intensive Care Patients

  NCT03886623

  Conditions:   Methicillin-resistant Staphylococcus Aureus;   Methicillin-Sensitive Staphylococcus Aureus Infection
  Interventions:   Procedure: 4-day systematic oral hygiene;   Other: Standard of Care oral care
  Sponsor:   Ohio State University
  Completed
• Cardiac Amyloidosis Screening at Trigger Finger Release

  NCT03886155

  Conditions:   Amyloidosis;   Trigger Finger;   Transthyretin Amyloidosis;   Primary Amyloidosis of Light Chain Type
  Intervention:   Procedure: Biopsy
  Sponsor:   The Cleveland Clinic
  Recruiting
• Efficacy of the Dabir Surfaces Micropressure Overlay for Decubitus Ulcer Prevention During Cardiac Surgery

  NCT03884634

  Conditions:   Pressure Ulcer;   Pressure Injury
  Intervention:   Device: Dabir Micropressure Overlay
  Sponsor:   The Cleveland Clinic
  Recruiting
• Cysteamine for Asthma

  NCT03883984

  Condition:   Asthma
  Interventions:   Drug: Cysteamine Bitartrate;   Drug: Placebo Oral Tablet
  Sponsor:   Children's Hospital Medical Center, Cincinnati
  Recruiting
• Donor-Derived Viral Specific T-cells (VSTs) for Prophylaxis Against Viral Infections After Allogeneic Stem Cell Transplant

  NCT03883906

  Conditions:   Allogeneic Stem Cell Transplant;   Viral Infection
  Intervention:   Biological: Viral Specific T-cells (VSTs)
  Sponsors:   Children's Hospital Medical Center, Cincinnati;   Hoxworth Blood Center
  Recruiting
• Technology-Assisted Stepped Care Study

  NCT03883594

  Condition:   Asthma
  Intervention:   Behavioral: Technology-assisted Stepped-care
  Sponsor:   Children's Hospital Medical Center, Cincinnati
  Recruiting
• Evaluation of Helmet Technology and Head Impact Exposure

  NCT03883451

  Conditions:   MTBI - Mild Traumatic Brain Injury;   Concussion, Mild
  Intervention:   Other: Helmet Model
  Sponsor:   Children's Hospital Medical Center, Cincinnati
  Active, not recruiting
• PoNS Clinical Experience Program (TBI)

  NCT03882554

  Condition:   Mild to Moderate Traumatic Brain Injury
  Intervention:   Device: PoNS Treatment
  Sponsors:   Neurohabilitation Corporation;   Ohio State University
  Recruiting
• Clinical Trial of Acupuncture for Chemotherapy-Induced Peripheral Neuropathy

  NCT03881748

  Condition:   Peripheral Neuropathy
  Interventions:   Other: Manual acupuncture;   Other: Electro-acupuncture
  Sponsor:   Case Comprehensive Cancer Center
  Not yet recruiting
• Nitrous Oxide for the Treatment of Complex Regional Pain Syndrome

  NCT03879538

  Condition:   Complex Regional Pain Syndrome
  Interventions:   Drug: Nitrous Oxide;   Drug: Oxygen
  Sponsor:   The Cleveland Clinic
  Recruiting
• rVWF Pediatric and Adult Study

  NCT03879135

  Condition:   Von Willebrand Disease
  Interventions:   Biological: rVWF;   Biological: rFVIII
  Sponsors:   Baxalta now part of Shire;   Baxalta Innovations GmbH, now part of Shire
  Recruiting
• Transcranial Direct Current Stimulation Therapy for Sleepiness Related to Shift Work Disorder (tDCS-SWORD)

  NCT03879044

  Condition:   Shift-Work Sleep Disorder
  Intervention:   Device: Transcranial Direct Current Stimulation
  Sponsor:   Ohio State University
  Recruiting
• Comparing Specimen Collection Techniques to Screen for Sexually Transmitted Infections in Pregnant Women: A Pilot Study

  NCT03877263

  Condition:   Sexually Transmitted Diseases
  Interventions:   Diagnostic Test: Endocervical swab for detection of STI;   Diagnostic Test: Vaginal swab for detection of STI
  Sponsor:   OhioHealth
  Recruiting
• rTMS Plus CCFES-mediated Functional Task Practice for Severe Stroke

  NCT03870672

  Conditions:   Stroke;   Hemiplegia;   Cerebrovascular Accident (CVA);   Hemiparesis
  Interventions:   Device: Contralaterally Controlled Functional Electrical Stimulation;   Device: New rTMS approach;   Device: Conventional rTMS approach;   Device: Sham rTMS approach
  Sponsors:   The Cleveland Clinic;   National Institutes of Health (NIH)
  Recruiting
• Potential Benefit for Non Invasive Vagus Nerve Stimulation Using GammaCore in the Treatment of Raynaud's Phenomena.

  NCT03869008

  Conditions:   Raynaud Phenomenon;   Primary Raynaud Phenomenon;   Raynaud Disease;   Raynaud Syndrome
  Interventions:   Device: gammaCore Sapphire;   Device: Sham Device
  Sponsors:   University of Toledo Health Science Campus;   ElectroCore INC
  Recruiting
• Brigatinib in Treating Patients With ALK and ROS1 Gene Alterations and Locally Advanced or Metastatic Solid Cancers

  NCT03868423

  Conditions:   Advanced Malignant Neoplasm;   ALK Fusion Protein Expression;   ALK Gene Amplification;   ALK Gene Mutation;   Locally Advanced Malignant Solid Neoplasm;   Metastatic Malignant Neoplasm in the Brain;   Metastatic Malignant Neoplasm in the Central Nervous System;   Metastatic Malignant Solid Neoplasm;   ROS1 Fusion Positive;   ROS1 Gene Amplification;   ROS1 Gene Mutation
  Interventions:   Drug: Brigatinib;   Other: Laboratory Biomarker Analysis;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration
  Sponsors:   Sameek Roychowdhury;   National Cancer Institute (NCI)
  Not yet recruiting
• A Novel Approach for Brain Stimulation in Severe Stroke

  NCT03868410

  Condition:   Stroke
  Interventions:   Device: New rTMS Approach;   Device: Conventional rTMS Approach
  Sponsors:   The Cleveland Clinic;   American Heart Association
  Recruiting
• Examining Developmental Outcomes of Children Diagnosed With CLN2 Disease

  NCT03862274

  Conditions:   Batten Disease;   CLN2;   Neuronal Ceroid-Lipofuscinoses
  Intervention:   Other: CLN2 Treatment
  Sponsors:   Jessica Scherr;   BioMarin Pharmaceutical
  Recruiting
• Precision of OCT and OCTA-based Ocular Measurements

  NCT03859310

  Condition:   Normal Eyes and Ocular Pathology
  Intervention:   Device: SD-OCT
  Sponsor:   Optovue
  Enrolling by invitation
• Inhaled Essential Oil Effect on Common QOL Concerns During Cancer Treatment

  NCT03858855

  Conditions:   Gastrointestinal Cancer;   Neuroendocrine Carcinoma;   Melanoma
  Interventions:   Procedure: Aromatherapy and Essential Oils;   Other: Subject Diary
  Sponsors:   Ohio State University Comprehensive Cancer Center;   National Cancer Institute (NCI)
  Enrolling by invitation
• CCFES + tDCS for Motor Control

  NCT03857529

  Conditions:   Active tDCS Concurrent With CCFES;   Active tDCS Preceding CCFES;   Sham tDCS With CCFES
  Intervention:   Device: transcranial direct current stimulation and electrical stimulator
  Sponsor:   MetroHealth Medical Center
  Recruiting
• Vaginal Prep Solutions to Reduce Bacteria Colony Counts in Patients Having a Vaginal Surgery

  NCT03854370

  Conditions:   Surgical Site Infection;   Vaginal Surgery
  Interventions:   Other: Baby shampoo;   Other: Betadine;   Other: Peridex;   Other: TechniCare
  Sponsor:   Wright State University
  Not yet recruiting
• Subcutaneous Methylnaltrexone Versus Placebo for Postoperative Ileus Prevention

  NCT03852524

  Condition:   Postoperative Ileus
  Interventions:   Drug: Methylnaltrexone;   Other: Placebo
  Sponsor:   Ohio State University
  Recruiting
• Effects of INDUS810 on Body Composition, Muscular Performance, and Training Adaptations

  NCT03850106

  Condition:   Weakness, Muscle
  Interventions:   Dietary Supplement: Placebo;   Dietary Supplement: Indus810
  Sponsors:   The Center for Applied Health Sciences, LLC;   Indus Biotech
  Active, not recruiting
• Study to Evaluate the Real-world Effectiveness of Lanadelumab in Participants With Hereditary Angioedema (HAE)

  NCT03845400

  Condition:   Hereditary Angioedema (HAE)
  Intervention:  
  Sponsor:   Shire
  Not yet recruiting
• Postpartum Family Planning

  NCT03844633

  Condition:   Delay in Time to Lactogenesis Stage II
  Interventions:   Drug: Depo-Provera Injectable Product;   Drug: Placebos
  Sponsors:   Ohio State University;   Nationwide Children's Hospital
  Recruiting
• A Randomized Phase 1 Dose-Escalation Study of Subcutaneously(SC) Administered RUC-4

  NCT03844191

  Condition:   Coronary Disease
  Intervention:   Drug: RUC-4 Compound
  Sponsors:   CeleCor Therapeutics;   Precision For Medicine;   CirQuest Labs;   CRL
  Recruiting
• Hypofractionated Radiotherapy for Recurrent DIPG

  NCT03841435

  Condition:   Recurrent Diffuse Intrinsic Pontine Glioma
  Intervention:   Radiation: Hypofractionated Radiotherapy
  Sponsors:   University of Cincinnati;   Children's Hospital Medical Center, Cincinnati
  Enrolling by invitation
• Continuous Bladder Irrigation Following Transurethral Resection of Bladder Tumors

  NCT03839472

  Conditions:   Non-muscle Invasive Bladder Cancer (NMIBC);   Bladder Tumor (TURBT)
  Intervention:   Procedure: CBI
  Sponsor:   Case Comprehensive Cancer Center
  Not yet recruiting
• Markers of Trajectory in Pediatric CRPS

  NCT03838107

  Condition:   Complex Regional Pain Syndromes
  Intervention:   Behavioral: observation and measure of trajectory of recovery in CRPS
  Sponsors:   Children's Hospital Medical Center, Cincinnati;   Chapman Family Donation
  Recruiting
• SAMPAP Trial -Impact of a Novel Sleep Apnea Management Group Intervention on Positive Airway Pressure Adherence

  NCT03835702

  Condition:   Sleep Apnea
  Intervention:   Other: SAM Clinic Intervention
  Sponsors:   The Cleveland Clinic;   ResMed
  Recruiting
• Urinary Retention After Laparoscopic Inguinal Hernia Repair: Comparing the Use of the Intraoperative Urinary Catheter

  NCT03835351

  Condition:   Inguinal Hernia
  Intervention:   Device: Urinary Catheter
  Sponsor:   The Cleveland Clinic
  Recruiting
• Addressing Fear and Risk of Vasovagal Reactions Among High School Donors

  NCT03835299

  Condition:   Blood Donors
  Intervention:   Behavioral: Fear Intervention
  Sponsors:   Ohio University;   New York Blood Center
  Enrolling by invitation
• Glutaminase Inhibitor CB-839 Hydrochloride and Osimertinib in Treating Patients With EGFR-Mutated Stage IV Non-small Cell Lung Cancer

  NCT03831932

  Conditions:   Advanced Lung Carcinoma;   EGFR Activating Mutation;   EGFR Exon 19 Deletion Mutation;   EGFR NP_005219.2:p.L858R;   EGFR T790M Mutation Negative;   Lung Non-Small Cell Carcinoma;   Metastatic Lung Carcinoma;   Stage IV Lung Cancer AJCC v8;   Stage IVA Lung Cancer AJCC v8;   Stage IVB Lung Cancer AJCC v8
  Interventions:   Drug: Glutaminase Inhibitor CB-839;   Drug: Glutaminase Inhibitor CB-839 Hydrochloride;   Drug: Osimertinib
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Lamotrigine in Reducing Psychologic Side-Effect of Perioperative Ketamine

  NCT03831854

  Condition:   Reducing Psychological Side Effects of Ketamine
  Interventions:   Drug: Lamotrigine 300 MG;   Drug: Placebo;   Drug: Ketamine
  Sponsor:   The Cleveland Clinic
  Recruiting
• Attentional Biases, Reward Sensitivity, and Cognitive Control in Adults With Bipolar Disorder

  NCT03829787

  Condition:   Bipolar Disorder
  Intervention:   Device: Eye tracking
  Sponsor:   University Hospitals Cleveland Medical Center
  Recruiting
• Improving Sexual Health in Gynecologic Cancer Patients

  NCT03827993

  Condition:   Gynecologic Cancer
  Intervention:   Behavioral: dedicated sexual health clinic appointment
  Sponsor:   Case Comprehensive Cancer Center
  Not yet recruiting
• Early Feasibility Study of the SENSE Device

  NCT03827720

  Conditions:   Hemorrhagic Stroke;   Ischemic Stroke
  Intervention:   Device: SENSE Device
  Sponsor:   Sense Diagnostics, LLC
  Not yet recruiting
• Venetoclax Combined With Vyxeos (CPX-351) for Participants With Relapsed or Refractory Acute Leukemia

  NCT03826992

  Condition:   Leukemia
  Interventions:   Drug: Vyxeos;   Drug: Venetoclax
  Sponsor:   Children's Hospital Medical Center, Cincinnati
  Recruiting
• Papaverine Hydrochloride and Stereotactic Body Radiation Therapy in Treating Patients With Non-small Cell Lung Cancer

  NCT03824327

  Condition:   Lung Non-Small Cell Carcinoma
  Interventions:   Procedure: Blood Oxygen Level Dependent Imaging;   Drug: Papaverine Hydrochloride;   Radiation: Stereotactic Body Radiation Therapy
  Sponsors:   Ohio State University Comprehensive Cancer Center;   National Cancer Institute (NCI)
  Recruiting
• Inadvertent Hyperventilation During Intraoperative Care in Neonates

  NCT03823716

  Condition:   Neonatal Disorder
  Intervention:  
  Sponsor:   Nationwide Children's Hospital
  Enrolling by invitation
• Virtual Prostate Biopsy Protocol for Patients on Active Surveillance and at Risk of Prostate Cancer

  NCT03823001

  Condition:   Prostate Cancer
  Intervention:   Diagnostic Test: virtual biopsy (VB) monitoring protocol
  Sponsor:   Case Comprehensive Cancer Center
  Not yet recruiting
• FibroScan ® Study: Assessing Liver Fibrosis in Patients Using Methotrexate for Psoriasis

  NCT03820934

  Condition:   Psoriasis
  Intervention:   Diagnostic Test: Fibroscan and Fibrosure
  Sponsor:   University Hospitals Cleveland Medical Center
  Recruiting
• Cost-effectiveness of Forced Aerobic Exercise for Stroke Rehabilitation

  NCT03819764

  Conditions:   Stroke;   Cerebrovascular Disorders;   Brain Diseases;   Central Nervous System Diseases;   Nervous System Diseases;   Vascular Diseases;   Cardiovascular Diseases
  Interventions:   Behavioral: Aerobic Exercise;   Behavioral: Upper Extremity Repetitive Task Practice
  Sponsor:   The Cleveland Clinic
  Recruiting
• Microbiome and Mycobiome Registry of Volunteers With and Without Autism Spectrum Disorder

  NCT03819439

  Condition:   Autism Spectrum Disorder
  Intervention:   Other: Microbiome and Autism Questionnaire
  Sponsor:   University Hospitals Cleveland Medical Center
  Recruiting
• Proton Based Cardiac Sparing Accelerated Fractionated RadioTherapy in Unresectable NSCLC

  NCT03818776

  Condition:   Non-Small Cell Lung Cancer
  Interventions:   Drug: Durvalumab;   Radiation: Proton beam therapy RT
  Sponsor:   Case Comprehensive Cancer Center
  Not yet recruiting
• Urinary Track Infection Prevention After Urogynecological Surgery

  NCT03818321

  Conditions:   Urinary Tract Infections;   Urinary Retention Postoperative;   Pelvic Organ Prolapse
  Interventions:   Drug: Methenamine Hippurate 1 g tablet;   Drug: Placebo tablet
  Sponsor:   TriHealth Inc.
  Not yet recruiting
• Incomplete Follow Up After Positive FIT or Stool DNA Testing: A Multimethod Approach

  NCT03817905

  Condition:   Positive FIT or Stool DNA Testing Follow up
  Intervention:   Other: Patient navigator
  Sponsor:   Case Comprehensive Cancer Center
  Not yet recruiting
• A Novel Wound Retractor Combining Continuous Irrigation and Barrier Protection Reduces Incisional Contamination and Surgical Site Infection in Colorectal Surgery

  NCT03816995

  Condition:   Colorectal Surgery
  Interventions:   Device: CleanCision Wound Retraction and Protection System;   Device: Alexis O Wound Protector
  Sponsor:   The Cleveland Clinic
  Recruiting
• A SAD/MAD to Assess the Safety, Pharmacokinetics and Pharmacodynamics of FT-4202 in Healthy Volunteers and Sickle Cell Disease Patients

  NCT03815695

  Conditions:   Healthy Volunteers;   Sickle Cell Disease
  Interventions:   Drug: FT-4202/Placebo;   Drug: FT-4202
  Sponsors:   Forma Therapeutics, Inc.;   Medpace, Inc.
  Recruiting
• Evaluation of Hospital Readmission Rate Dependent on Post-Operative Follow-Up Procedure

  NCT03813537

  Condition:   Postoperative Complications
  Intervention:   Other: Phone Call
  Sponsor:   Syed Husain
  Recruiting
• Spontaneous Void Requirements for Patients Undergoing Ambulatory Anorectal Surgery

  NCT03812536

  Condition:   Complications, Postoperative
  Intervention:   Other: No Void
  Sponsor:   Syed Husain
  Recruiting
• Comparison Air Versus Carbon Dioxide Insufflation in Single Balloon Anterograde Enteroscopy

  NCT03811522

  Conditions:   Carbon Dioxide Insufflation;   Anterograde Single Balloon Enteroscopy
  Interventions:   Other: carbon dioxide insufflation;   Other: Air insufflation
  Sponsors:   North Eastern Ohio Gastroenterology and Endoscopy center;   Mercy Health Ohio
  Active, not recruiting
• Female Patient Preferences Regarding Physician Gender

  NCT03811340

  Condition:   Female Patient Preference
  Intervention:  
  Sponsor:   TriHealth Inc.
  Active, not recruiting
• Effects of a Metronome on Functional Outcomes in Aquatic Therapy

  NCT03801772

  Condition:   Exercise Therapy
  Intervention:   Device: Metronome
  Sponsor:   Aultman Health Foundation
  Recruiting
• Utilization of Hepatitis C Positive Kidneys in Negative Recipients

  NCT03801707

  Conditions:   Kidney Transplant;   Hepatitis C;   HCV
  Intervention:   Drug: Sofosbuvir/Velpatasvir
  Sponsor:   Ohio State University
  Recruiting
• Predicting the Development of Myocardial Depression in Acute Neurological Patients

  NCT03801694

  Conditions:   Myocardial Depression;   Takotsubo Syndrome;   Subarachnoid Hemorrhage;   Acute Ischemic Stroke
  Intervention:  
  Sponsor:   Ohio State University
  Recruiting
• Threshold Response of Lumbar Selective Nerve Root Block in Predicting Good Outcome Following Lumbar Foraminotomy

  NCT03801356

  Conditions:   Back Pain;   Radiculopathy Lumbar;   Degenerative Lumbar Spinal Stenosis
  Intervention:   Diagnostic Test: Selective Nerve Root Block
  Sponsors:   The Cleveland Clinic;   Lumbar Spine Research Society
  Recruiting
• Stimulation Parameters and Non-motor Symptoms in PD Treated With DBS

  NCT03800108

  Condition:   Parkinson Disease
  Intervention:   Procedure: Personalized DBS adjustments
  Sponsor:   Darlene Floden
  Recruiting
• Real World Effectiveness of Combining an Employer-based Weight Management Program With Medication for Chronic Weight Management in Employees With Obesity

  NCT03799198

  Condition:   Obesity
  Interventions:   Other: Weight Management Program (WMP);   Drug: Medication for chronic weight management (Rx)
  Sponsor:   Novo Nordisk A/S
  Active, not recruiting
• Nivolumab and Radiation Therapy or Ipilimumab as Adjuvant Therapy in Treating Patients With Merkel Cell Cancer

  NCT03798639

  Conditions:   Merkel Cell Carcinoma;   Pathologic Stage IIIA Merkel Cell Carcinoma AJCC v8;   Pathologic Stage IIIB Merkel Cell Carcinoma AJCC v8
  Interventions:   Biological: Ipilimumab;   Biological: Nivolumab;   Radiation: Radiation Therapy
  Sponsors:   Hiral Shah;   National Cancer Institute (NCI)
  Recruiting
• Accuracy of the Apple Watch Series 4 for Detection of Heart Rhythm: A Pilot Study

  NCT03798613

  Conditions:   Heart Rate Fast;   Heart Rate Low
  Interventions:   Device: Apple Watch 4 Series Device;   Device: Continuous Telemetry Monitor
  Sponsors:   The Cleveland Clinic;   Case Western Reserve University
  Completed
• CI Following VS Removal or Labyrinthectomy

  NCT03795675

  Conditions:   Vestibular Schwannoma;   Meniere Disease
  Intervention:   Device: Cochlear Implant
  Sponsors:   Ohio State University;   Advanced Bionics
  Recruiting
• Comparison of Anticoagulation With Left Atrial Appendage Closure After AF Ablation

  NCT03795298

  Condition:   Atrial Fibrillation
  Interventions:   Device: WATCHMAN FLX Implant;   Drug: Market-approved OAC
  Sponsor:   Boston Scientific Corporation
  Recruiting
• Impact of OSA on Outcomes in Acute Coronary Syndrome

  NCT03793582

  Conditions:   OSA;   ACS - Acute Coronary Syndrome;   Major Adverse Cardiac Events
  Intervention:   Diagnostic Test: ApneaLink Type III portable sleep study
  Sponsor:   MetroHealth Medical Center
  Recruiting
• Evaluating The Efficacy Of A Mind-Body Intervention In Overcoming Opioid Addiction

  NCT03791645

  Conditions:   Opioid Use;   Opioid-use Disorder;   Substance Use Disorders
  Intervention:   Behavioral: Sky Intervention
  Sponsor:   Ohio State University
  Recruiting
• Hydroxyurea Optimization Through Precision Study

  NCT03789591

  Conditions:   Sickle Cell Disease;   Sickle Cell Anemia
  Intervention:   Drug: Hydroxyurea
  Sponsors:   Children's Hospital Medical Center, Cincinnati;   Doris Duke Charitable Foundation
  Recruiting
• Study of Euthyroid Hypothyroxinemia in Metastatic Breast Carcinoma

  NCT03787303

  Conditions:   Metastatic Breast Cancer;   Thyroid Dysfunction
  Intervention:   Drug: Triiodothyronine (T3)
  Sponsor:   Aultman Health Foundation
  Recruiting
• A Placebo-Controlled, Two-Part Study, Oral Dose to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of CNTX-6970 in Healthy Subjects

  NCT03787004

  Conditions:   Chronic Pain;   Nociceptive Pain
  Interventions:   Drug: CNTX-6970;   Other: Placebo
  Sponsor:   Centrexion Therapeutics
  Completed
• Stress, Sex, and Fear

  NCT03786952

  Condition:   Psychological Stress
  Interventions:   Behavioral: Stress immediately before learning in males;   Behavioral: Sham control immediately before learning in males;   Behavioral: Stress 30 minutes before learning in males;   Behavioral: Sham control 30 minutes before learning in males;   Behavioral: Stress immediately before learning in females;   Behavioral: Sham control immediately before learning in females;   Behavioral: Stress 30 minutes before learning in females;   Behavioral: Sham control 30 minutes before learning in females
  Sponsors:   Ohio Northern University;   National Institute of Mental Health (NIMH)
  Recruiting
• Intensity Modulated Radiation Therapy or 3-Dimensional Conformal Radiation Therapy in Treating Patients With Lymph-Node Positive Breast Cancer

  NCT03786354

  Conditions:   Anatomic Stage II Breast Cancer AJCC v8;   Anatomic Stage IIA Breast Cancer AJCC v8;   Anatomic Stage IIB Breast Cancer AJCC v8;   Anatomic Stage III Breast Cancer AJCC v8;   Anatomic Stage IIIA Breast Cancer AJCC v8;   Anatomic Stage IIIB Breast Cancer AJCC v8;   Anatomic Stage IIIC Breast Cancer AJCC v8;   Lymph Node Involvement;   Prognostic Stage II Breast Cancer AJCC v8;   Prognostic Stage IIA Breast Cancer AJCC v8;   Prognostic Stage IIB Breast Cancer AJCC v8;   Prognostic Stage III Breast Cancer AJCC v8;   Prognostic Stage IIIA Breast Cancer AJCC v8;   Prognostic Stage IIIB Breast Cancer AJCC v8;   Prognostic Stage IIIC Breast Cancer AJCC v8
  Interventions:   Radiation: 3-Dimensional Conformal Radiation Therapy;   Radiation: Intensity-Modulated Radiation Therapy
  Sponsors:   Ohio State University Comprehensive Cancer Center;   National Cancer Institute (NCI)
  Recruiting
• The Effect of Histopathologic Analysis and Tissue Cultures on Inpatient Management of Cellulitis and Pseudocellulitis

  NCT03785834

  Conditions:   Cellulitis;   Pseudocellulitis
  Intervention:   Procedure: Punch Biopsy
  Sponsor:   Ohio State University
  Recruiting
• Utilization of the Mirror During Pelvic Exams

  NCT03785548

  Condition:   Pelvic Exam
  Intervention:   Other: Usage of a mirror
  Sponsor:   TriHealth Inc.
  Recruiting
• SASH Study - Sonographic Assessment for Severe Hypertension in Pregnancy

  NCT03783169

  Condition:   Hypertension in Pregnancy
  Intervention:   Other: Cardiovascular Sonographic Assessment
  Sponsor:   TriHealth Inc.
  Recruiting
• Sleep After Adolescent Concussion

  NCT03781076

  Condition:   Brain Concussion
  Intervention:   Behavioral: Sleep Intervention
  Sponsors:   Children's Hospital Medical Center, Cincinnati;   Cincinnati Children's Research Foundation
  Recruiting
• Spironolactone Versus Prednisolone in DMD

  NCT03777319

  Condition:   Muscular Dystrophy, Duchenne
  Interventions:   Drug: Spironolactone;   Drug: Prednisolone
  Sponsors:   Kevin Flanigan;   Muscular Dystrophy Association
  Recruiting
• Prematurity Education in High Risk Pregnancies

  NCT03772080

  Conditions:   Prematurity;   High Risk Pregnancy
  Intervention:   Other: Early counseling of prematurity in high-risk pregnancies.
  Sponsors:   University Hospitals Cleveland Medical Center;   Rainbow Babies and Children's Hospital
  Recruiting
• Pharmacokinetic and Pharmacodynamic Analysis of Ceftaroline in Children and Adolescents With Cystic Fibrosis

  NCT03771313

  Condition:   Cystic Fibrosis
  Intervention:   Drug: Ceftaroline
  Sponsor:   Children's Hospital Medical Center, Cincinnati
  Recruiting
• Hearing Aid Noise Reduction in Pediatric Users (Oticon Study)

  NCT03771287

  Conditions:   Hearing Impairment;   Hearing Loss, Sensorineural
  Interventions:   Device: Oticon OpenSound Navigator speech enhancement algorithm;   Device: Oticon omni-directional microphone algorithm
  Sponsors:   Children's Hospital Medical Center, Cincinnati;   Oticon
  Recruiting
• Gene Transfer Study of AAV9-CLN3 for Treatment NCL Type 3

  NCT03770572

  Condition:   CLN3-Related Neuronal Ceroid-Lipofuscinosis
  Intervention:   Biological: AAV9-CLN3
  Sponsors:   Nationwide Children's Hospital;   Amicus Therapeutics
  Recruiting
• Registry for Advanced Sarcodiosis

  NCT03769987

  Condition:   Sarcoidosis
  Intervention:   Other: observation
  Sponsor:   University of Cincinnati
  Recruiting
• A Randomized, Double-blind, Placebo-controlled Study of SRP-9001 for Duchenne Muscular Dystrophy (DMD)

  NCT03769116

  Condition:   Muscular Dystrophy, Duchenne
  Interventions:   Drug: SRP-9001;   Drug: Placebo
  Sponsor:   Sarepta Therapeutics
  Recruiting
• Temporally Feathered Radiation Therapy (TFRT) for Head and Neck Squamous Cell Carcinoma

  NCT03768856

  Condition:   Head and Neck Cancer
  Intervention:   Radiation: Temporally Feathered Radiation Therapy (TFRT)
  Sponsor:   Case Comprehensive Cancer Center
  Recruiting
• Can The Bridge Transition Opiate Use Disorder Patients in Stable Recovery From Buprenorphine to Naltrexone

  NCT03762798

  Conditions:   Substance Use Disorders;   Substance Abuse;   Substance Use;   Substance Dependence
  Intervention:   Device: The Bridge
  Sponsor:   The Cleveland Clinic
  Recruiting
• A Pilot Study of Optic Nerve Ultrasound Following Cardiopulmonary Bypass

  NCT03757312

  Conditions:   Congenital Heart Disease;   Congenital Heart Defect
  Intervention:   Diagnostic Test: Ultrasound
  Sponsor:   Marco Corridore
  Enrolling by invitation
• Comparison of Three Balance Training Protocols for Individuals Post Stroke

  NCT03757026

  Conditions:   Fall;   Risk Reduction;   Stroke;   Balance
  Interventions:   Other: Conventional Physical Therapy;   Other: Slip Training;   Other: Harnessed gaming
  Sponsors:   Cleveland State University;   American Heart Association
  Recruiting
• Mind Body Interventions for the Student Population

  NCT03756701

  Conditions:   Chronic Pain;   Anxiety;   Stress
  Intervention:   Behavioral: Mind body skills
  Sponsor:   Youngstown State University
  Recruiting
• Evaluation of Clinical Outcomes of Pulse Widths in Spinal Cord Stimulation

  NCT03756012

  Conditions:   Back Pain;   Pain
  Intervention:   Device: Algovita Spinal Cord Stimulation System
  Sponsor:   Kettering Health Network
  Recruiting
• Online Mindfulness Program for Stress Management

  NCT03753360

  Conditions:   Stress, Psychological;   Burnout, Professional
  Interventions:   Behavioral: Internet-Based Mindfulness Program - Stress Free Now for Healers;   Behavioral: Active Control Group - Relaxing Music
  Sponsor:   The Cleveland Clinic
  Recruiting
• Robotic Walking Device to Improve Mobility in Parkinson's Disease

  NCT03751371

  Condition:   Parkinson Disease
  Interventions:   Device: Training with HWA device;   Other: Usual Care
  Sponsors:   Ohio State University;   Michael J. Fox Foundation for Parkinson's Research;   Honda Research and Development Americas, Inc
  Recruiting
• Nivolumab With DA-REPOCH Chemotherapy Regimen in Treating Patients With Aggressive B-Cell Non-Hodgkin's Lymphoma

  NCT03749018

  Conditions:   Aggressive Non-Hodgkin Lymphoma;   Ann Arbor Stage I Primary Mediastinal (Thymic) Large B-Cell Cell Lymphoma;   Ann Arbor Stage II B-Cell Non-Hodgkin Lymphoma;   Ann Arbor Stage II Primary Mediastinal (Thymic) Large B-Cell Cell Lymphoma;   Ann Arbor Stage III B-Cell Non-Hodgkin Lymphoma;   Ann Arbor Stage III Primary Mediastinal (Thymic) Large B-Cell Cell Lymphoma;   Ann Arbor Stage IV B-Cell Non-Hodgkin Lymphoma;   Ann Arbor Stage IV Primary Mediastinal (Thymic) Large B-Cell Cell Lymphoma;   Diffuse Large B-Cell Lymphoma;   High Grade B-Cell Lymphoma With MYC and BCL2 and/or BCL6 Rearrangements;   High Grade B-Cell Lymphoma, Not Otherwise Specified;   Indolent Non-Hodgkin Lymphoma;   Mediastinal B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma and Classic Hodgkin Lymphoma;   Transformed Non-Hodgkin Lymphoma
  Interventions:   Drug: Cyclophosphamide;   Drug: Doxorubicin Hydrochloride;   Drug: Etoposide;   Biological: Nivolumab;   Drug: Prednisone;   Biological: Rituximab;   Drug: Vincristine Sulfate
  Sponsors:   Kami Maddocks;   National Cancer Institute (NCI);   Bristol-Myers Squibb
  Not yet recruiting
• Comparative Evaluation of Lumbar Plexus and Suprainguinal Fascia Iliaca Compartment Blocks

  NCT03746951

  Condition:   Orthopedic Disorder
  Intervention:   Drug: Ropivacaine Hcl 0.5% Inj Vil 20Ml
  Sponsor:   Nationwide Children's Hospital
  Enrolling by invitation
• Air Pollution: Strategies for Personalized Intervention to Reduce Exposure

  NCT03744871

  Condition:   Air Pollution
  Intervention:   Device: Respirator Use
  Sponsors:   University Hospitals Cleveland Medical Center;   University of Michigan;   Peking University
  Not yet recruiting
• Mastering Diabetes Pilot Study

  NCT03743779

  Condition:   Diabetes Mellitus
  Intervention:   Behavioral: Mastering Diabetes
  Sponsor:   Ohio University
  Recruiting
• Influence of Aerobic Training and Weight Loss on Skeletal Muscle Inflammatory Markers and Muscle Protein Balance in Older Adults

  NCT03743675

  Conditions:   Overweight and Obesity;   Inflammation; Muscle;   Sedentary Lifestyle
  Interventions:   Behavioral: Diet-Induced Weight Loss;   Behavioral: Aerobic Exercise Training
  Sponsor:   Miami University
  Recruiting
• Pectoralis and Serratus Muscle Blocks

  NCT03743194

  Condition:   Post Operative Pain Control
  Interventions:   Drug: Exparel 266 MG Per 20 ML Injection;   Drug: Placebo
  Sponsor:   The Cleveland Clinic
  Recruiting
• Peru Longitudinal Study

  NCT03742219

  Conditions:   Cardiovascular Diseases;   Diabetes Mellitus;   Hypertension;   Dyslipidemias;   Overweight and Obesity
  Intervention:   Behavioral: Lifestyle Modification
  Sponsor:   Ohio University
  Recruiting
• Personal Activity Intelligence (PAI) Pilot

  NCT03740074

  Conditions:   Overweight and Obesity;   Diabetes;   Hypertension;   Dyslipidemias;   Cardiovascular Diseases
  Intervention:   Behavioral: PAI
  Sponsor:   Ohio University
  Recruiting
• Evaluation of a Lifestyle Medicine Practice

  NCT03739034

  Conditions:   Chronic Lifestyle Related Disease;   Diabetes;   Overweight and Obesity;   Dyslipidemias;   Hypertension;   Cardiovascular Diseases
  Intervention:   Behavioral: Lifestyle Medicine
  Sponsor:   Ohio University
  Recruiting
• Brain Connections and Blood Pressure

  NCT03736434

  Conditions:   Hypertension;   Mild Cognitive Impairment
  Interventions:   Behavioral: Mindfulness and DASH Diet Education;   Behavioral: Education group
  Sponsor:   Ohio State University
  Recruiting
• The Effect of Two Aspirin Dosing Strategies for Obese Women at High Risk for Preeclampsia

  NCT03735433

  Condition:   Preeclampsia
  Intervention:   Drug: 162mg aspirin dose
  Sponsor:   Ohio State University
  Recruiting
• Comparative Analysis of CO2 Monitoring Methods in Patients With CF Undergoing General Anesthesia

  NCT03734822

  Condition:   Cystic Fibrosis
  Interventions:   Other: End tidal CO2 (EtCO2);   Device: Transcutaneous CO2 (TCO2);   Diagnostic Test: Capillary CO2 (CapCO2);   Diagnostic Test: Arterial blood gas (ABG)
  Sponsor:   Nationwide Children's Hospital
  Completed
• Technology- Assisted Stepped Care Intervention Study

  NCT03733457

  Condition:   Asthma
  Intervention:   Behavioral: Technology-assisted Stepped-care
  Sponsor:   Children's Hospital Medical Center, Cincinnati
  Recruiting
• WellStart Reboot Study

  NCT03731533

  Condition:   Type 2 Diabetes Mellitus
  Intervention:   Behavioral: WellStart
  Sponsor:   Ohio University
  Not yet recruiting
• Virtual Lifestyle Medicine Comparative Effectiveness Research

  NCT03731481

  Conditions:   Chronic Disease;   Obesity;   Sleep Disorder;   Depression
  Intervention:   Behavioral: Lifestyle Medicine
  Sponsors:   Ohio University;   Live Healthy Appalachia;   Ardmore Institute of Health;   OhioHealth;   Lifestyle Medicine Institute
  Completed
• Pectoral Fascial Plane and Serratus Anterior Plane Blocks With Bupivacaine v. Liposomal Bupivacaine

  NCT03731221

  Condition:   Video Assisted Thoracic Surgery
  Interventions:   Drug: Bupi HCI and lipo bupi;   Drug: Bupi HCI
  Sponsor:   The Cleveland Clinic
  Recruiting
• Same Day Discharge After Minimally-invasive Sacrocolpopexy

  NCT03730103

  Condition:   Pelvic Organ Prolapse
  Intervention:   Other: Same day discharge
  Sponsor:   The Cleveland Clinic
  Recruiting
• Ultrasound to Verify Lung-isolation During Single-lung Ventilation

  NCT03729999

  Condition:   Thoracic Diseases
  Intervention:   Device: Portable, Point-of-Care Ultrasound
  Sponsor:   Nationwide Children's Hospital
  Recruiting
• Nivolumab and Temozolomide in Treating Patients With Recurrent or Refractory Small-Cell Lung Cancer or Advanced Neuroendocrine Cancer

  NCT03728361

  Conditions:   Grade I Neuroendocrine Carcinoma;   Grade II Neuroendocrine Carcinoma;   Grade III Neuroendocrine Carcinoma;   Metastatic Neuroendocrine Carcinoma;   Neuroendocrine Carcinoma;   Recurrent Small Cell Lung Carcinoma;   Refractory Small Cell Lung Carcinoma;   Lung Cancer Stage IV;   Large Cell Neuroendocrine Carcinoma;   Neuroendocrine Tumors;   Small Cell Lung Cancer Metastatic;   Small-cell Lung Cancer
  Interventions:   Biological: Nivolumab;   Drug: Temozolomide
  Sponsors:   Dwight Owen;   National Cancer Institute (NCI)
  Recruiting
• Sensory Stimulation During Simulated Driving

  NCT03726840

  Condition:   Behavior
  Intervention:   Other: Fragrance
  Sponsor:   Children's Hospital Medical Center, Cincinnati
  Recruiting
• The Effect of Bariatric Surgery on Spermatogenesis

  NCT03725696

  Conditions:   Bariatric Surgery Candidate;   Sexual Function and Fertility Disorders
  Interventions:   Diagnostic Test: Semen Analysis;   Diagnostic Test: Hormonal panel;   Procedure: RYGB Gastric Bypass;   Diagnostic Test: IIEF Survey
  Sponsor:   The Cleveland Clinic
  Not yet recruiting
• A COmmunity and Tech-Based ApproaCh for Hypertension Self-MANagement

  NCT03724487

  Conditions:   Hypertension;   Self-management;   Technology;   Community-based Participatory Research
  Interventions:   Behavioral: Coachman;   Behavioral: Enhanced Usual Care (EUC)
  Sponsors:   Case Western Reserve University;   University Hospitals Cleveland Medical Center
  Not yet recruiting
• An Evaluation of a Collagen Dressing to Treat Chronic, Stalled Lower-extremity Wounds

  NCT03723603

  Condition:   Wound
  Intervention:   Device: Fibrillar collagen powder dressing
  Sponsor:   Medline Industries
  Recruiting
• The Effects of Mindfulness-based Stress Reduction in Interstitial Cystitis Patients

  NCT03722992

  Condition:   Interstitial Cystitis
  Intervention:   Other: MBSR
  Sponsor:   TriHealth Inc.
  Active, not recruiting
• Technology-based Intervention and Positive Psychological Training for Blood Pressure Control in African Americans

  NCT03722667

  Conditions:   Hypertension;   Self-management;   Technology
  Interventions:   Behavioral: Technology-based Component;   Behavioral: TechSupport
  Sponsors:   Case Western Reserve University;   University Hospitals Cleveland Medical Center
  Recruiting
• High Dose Vitamin A in Preventing Gastrointestinal GVHD in Participants Undergoing Donor Stem Cell Transplant

  NCT03719092

  Condition:   Allogeneic Hematopoietic Stem Cell Transplantation Recipient
  Intervention:   Dietary Supplement: Vitamin A Compound
  Sponsors:   Ohio State University Comprehensive Cancer Center;   National Cancer Institute (NCI)
  Not yet recruiting
• Nipple Aspirate Fluid in Detecting Breast Cancer

  NCT03715959

  Conditions:   Anatomic Stage IA Breast Cancer AJCC v8;   Anatomic Stage IB Breast Cancer AJCC v8;   Anatomic Stage II Breast Cancer AJCC v8;   Anatomic Stage IIA Breast Cancer AJCC v8;   Anatomic Stage IIB Breast Cancer AJCC v8;   Anatomic Stage III Breast Cancer AJCC v8;   Anatomic Stage IIIA Breast Cancer AJCC v8;   Anatomic Stage IIIB Breast Cancer AJCC v8;   Anatomic Stage IIIC Breast Cancer AJCC v8;   Anatomic Stage IV Breast Cancer AJCC v8;   Estrogen Receptor Negative;   Healthy Subject;   HER2 Positive Breast Carcinoma;   HER2/Neu Negative;   Luminal A Breast Carcinoma;   Luminal B Breast Carcinoma;   Progesterone Receptor Negative;   Prognostic Stage I Breast Cancer AJCC v8;   Prognostic Stage IA Breast Cancer AJCC v8;   Prognostic Stage IB Breast Cancer AJCC v8;   Prognostic Stage II Breast Cancer AJCC v8;   Prognostic Stage IIB Breast Cancer AJCC v8;   Prognostic Stage III Breast Cancer AJCC v8;   Prognostic Stage IIIA Breast Cancer AJCC v8;   Prognostic Stage IIIB Breast Cancer AJCC v8;   Prognostic Stage IIIC Breast Cancer AJCC v8;   Prognostic Stage IV Breast Cancer AJCC v8;   Triple-Negative Breast Carcinoma
  Interventions:   Procedure: Aspiration of Breast;   Procedure: Biospecimen Collection
  Sponsors:   Ohio State University Comprehensive Cancer Center;   National Cancer Institute (NCI)
  Not yet recruiting
• A Pilot Study: a Non-opioid Technique for Postoperative Adenoidectomy Pain Relief in Pediatric Patients

  NCT03714919

  Condition:   Adenoid Hypertrophy
  Interventions:   Drug: Dextromethorphan;   Drug: Acetaminophen;   Drug: Dexmedetomidine;   Drug: Ketamine
  Sponsor:   Arlyne Thung
  Enrolling by invitation
• Evaluation of Providing Coffee to Patients Postoperatively to Decrease Length of Stay in the PACU

  NCT03712891

  Conditions:   PACU Length of Stay;   Postoperative Nausea;   Postoperative Vomiting;   Patient Satisfaction
  Intervention:   Dietary Supplement: Coffee
  Sponsor:   TriHealth Inc.
  Recruiting