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Ohio

• Nivolumab in Combination With Talazoparib in Melanoma and Mutations in BRCA or BRCA-ness Genes

  NCT04187833

  Condition:   Metastatic or Unresectable Melanoma
  Interventions:   Drug: Nivolumab;   Drug: Talazoparib
  Sponsor:   Pauline Funchain
  Not yet recruiting
• 5-Azacitidine and Decitabine Epigenetic Therapy for Myeloid Malignancies

  NCT04187703

  Conditions:   Myelodysplastic Syndromes;   MDS/MPN Crossover Syndromes
  Interventions:   Drug: 5-azacytidine;   Drug: Decitabine
  Sponsor:   Case Comprehensive Cancer Center
  Not yet recruiting
• Personalized Treatment Algorithms for Difficult-to-treat Asthma

  NCT04179461

  Condition:   Asthma in Children
  Interventions:   Drug: Cholecalciferol;   Drug: antihistamine;   Drug: Azithromycin;   Drug: emollient cream;   Drug: Fluticasone Propionate;   Drug: Asthma Controller Medication
  Sponsor:   Children's Hospital Medical Center, Cincinnati
  Completed
• A 48-Week, Open Label, Study to Evaluate the Efficacy and Safety of Casimersen, Eteplirsen and Golodirsen in Subjects With Duchenne Muscular Dystrophy Carrying Eligible DMD Duplications

  NCT04179409

  Condition:   Duchenne Muscular Dystrophy
  Interventions:   Drug: Casimersen;   Drug: Eteplirsen;   Drug: Golodirsen
  Sponsors:   Kevin Flanigan;   Sarepta Therapeutics, Inc.
  Not yet recruiting
• Phase I Norovirus Challenge Model

  NCT04174560

  Condition:   Gastroenteritis Norovirus
  Intervention:   Biological: Norovirus GII.4 Challenge Pool
  Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
  Not yet recruiting
• Registry of Patients With a Diagnosis of Spinal Muscular Atrophy (SMA)

  NCT04174157

  Condition:   Spinal Muscular Atrophy (SMA)
  Intervention:   Other: Prospective observational registry
  Sponsors:   AveXis, Inc.;   United BioSource Corporation
  Recruiting
• Tools to Improve Medication Continuity in Adolescents With ADHD

  NCT04173000

  Condition:   Attention Deficit Hyperactivity Disorder
  Interventions:   Other: Mehealth for ADHD software with medication continuity tools;   Other: Mehealth for ADHD software with no medication continuity tools
  Sponsor:   Children's Hospital Medical Center, Cincinnati
  Recruiting
• GDNF Gene Therapy for Parkinson's Disease

  NCT04167540

  Condition:   Parkinson's Disease
  Intervention:   Biological: AAV2-GDNF
  Sponsor:   Brain Neurotherapy Bio, Inc.
  Not yet recruiting
• Dasatinib in Preventing Oxaliplatin-Induced Peripheral Neuropathy in Patients With Colorectal Cancer Receiving FOLFOX and Bevacizumab

  NCT04164069

  Conditions:   Advanced Colorectal Carcinoma;   Metastatic Colorectal Carcinoma;   Stage IV Colorectal Cancer AJCC v8;   Stage IVA Colorectal Cancer AJCC v8;   Stage IVB Colorectal Cancer AJCC v8;   Stage IVC Colorectal Cancer AJCC v8
  Interventions:   Biological: Bevacizumab;   Drug: Dasatinib;   Drug: Fluorouracil;   Drug: Leucovorin;   Drug: Leucovorin Calcium;   Drug: Oxaliplatin;   Other: Quality-of-Life Assessment
  Sponsors:   Anne Noonan;   National Cancer Institute (NCI)
  Not yet recruiting
• Contingency Management Using Smartphone App in Patients With SUD

  NCT04162132

  Condition:   Substance Use Disorders
  Intervention:   Device: Smartphone app
  Sponsors:   BrightView LLC;   DynamiCare Health
  Completed
• An Open Label Study to Evaluate the Impact of Duration of Subcutaneous Infusion of a Novel, pH Neutral Formulation of Furosemide (Furoscix®) on Safety and Local Skin Tolerability

  NCT04161482

  Condition:   Healthy
  Intervention:   Drug: Furosemide 80 mg (8 mg/mL)
  Sponsors:   scPharmaceuticals, Inc.;   Clinical Trial Data Services, Inc.;   CSSi Life Sciences
  Not yet recruiting
• Study of Autologous Peripheral Blood Lymphocytes in the Treatment of Patients With CLL or SLL

  NCT04155710

  Conditions:   Chronic Lymphocytic Leukemia;   Small Lymphocytic Lymphoma
  Interventions:   Biological: IOV-2001;   Drug: Low dose IL-2;   Drug: High dose IL-2;   Drug: IL-2
  Sponsor:   Iovance Biotherapeutics, Inc.
  Recruiting
• Arts & Health Education to Improve Health, Resilience, and Well-Being

  NCT04154579

  Conditions:   Hypertension;   Diabetes;   Obesity;   COPD;   CHF;   High Cholesterol;   Asthma;   Chronic Pain;   Multiple Sclerosis;   Depression;   Anxiety;   Heart Diseases;   Stroke
  Interventions:   Behavioral: HeRe We Arts;   Behavioral: HeRe We Ed
  Sponsors:   The Cleveland Clinic;   National Endowment for the Arts;   Cuyahoga Arts and Culture
  Recruiting
• Spiritual Flow and Nurse Wellbeing

  NCT04153656

  Condition:   Burnout, Professional
  Intervention:   Other: Reading and studying Spiritual Flow
  Sponsors:   Mercy Health Ohio;   St. Elizabeth Youngstown Hospital
  Recruiting
• Cooking Matters for Diabetes - A 6-Week Program for Practical Application of Diabetes Self-Management Education

  NCT04152811

  Conditions:   Diabetes Mellitus;   Type 1 Diabetes;   Type 2 Diabetes
  Interventions:   Behavioral: Cooking Matters for Diabetes;   Other: Usual Diabetes Care
  Sponsors:   Ohio State University;   Academy of Nutrition and Dietetics
  Recruiting
• Randomized Controlled Trial Comparing eTEP and Laparoscopic Intraperitoneal Onlay Mesh (IPOM) for Ventral Hernias

  NCT04150796

  Conditions:   Ventral Hernia;   Umbilical Hernia;   Epigastric Hernia
  Intervention:   Procedure: Ventral Hernia Repair
  Sponsor:   The Cleveland Clinic
  Recruiting
• Aspirin Effects on Emotional Reactions

  NCT04146532

  Condition:   Healthy Adults
  Interventions:   Drug: Aspirin 500 MG;   Drug: Placebo
  Sponsor:   Ohio State University
  Recruiting
• Quantitative Magnetic Resonance Imaging (MRI) Sub-Study of MS PATHS

  NCT04145284

  Condition:   Multiple Sclerosis
  Intervention:  
  Sponsor:   Biogen
  Enrolling by invitation
• Clinical Validation of Omron WheezeScan

  NCT04144699

  Conditions:   Asthma in Children;   Bronchitis;   Bronchiolitis
  Intervention:  
  Sponsors:   Omron Healthcare Co., Ltd.;   University of Wisconsin, Madison;   Children's Hospital Medical Center, Cincinnati;   Le Bonheur Children's Hospital;   University of Chicago
  Recruiting
• Patient-Centered PD Ambulatory Monitoring System

  NCT04142528

  Condition:   Parkinson Disease
  Intervention:   Device: ParkinPal
  Sponsors:   Great Lakes NeuroTechnologies Inc.;   National Institute of Nursing Research (NINR)
  Enrolling by invitation
• Digital PET Scan for the Prediction of Outcomes in Patients With Locally Advanced Oropharyngeal Cancer

  NCT04140513

  Conditions:   Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8;   Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8;   Locally Advanced Oropharyngeal Squamous Cell Carcinoma;   Pathologic Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8;   Pathologic Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8;   Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8;   Stage IVA Oropharyngeal (p16-Negative) Carcinoma AJCC v8;   Stage IVB Oropharyngeal (p16-Negative) Carcinoma AJCC v8
  Interventions:   Radiation: Fludeoxyglucose F-18;   Procedure: Positron Emission Tomography
  Sponsors:   Ohio State University Comprehensive Cancer Center;   National Cancer Institute (NCI)
  Not yet recruiting
• Vitamin D Supplementation as a Neoadjuvant for Photodynamic Therapy of Actinic Keratoses

  NCT04140292

  Condition:   Actinic Keratosis
  Interventions:   Drug: Photodynamic therapy (PDT);   Drug: Vitamin D3
  Sponsor:   Case Comprehensive Cancer Center
  Not yet recruiting
• Standing Balance as the Fifth Vital Sign in Clinical Setting

  NCT04139642

  Conditions:   Accidental Fall;   Postural Balance;   Clinical Decision-making
  Intervention:   Device: SimpleSway
  Sponsors:   Ohio State University;   Bertec Corporation;   National Institute on Aging (NIA)
  Recruiting
• Motor Unit Number Estimation (MUNE) in Adults With Spinal Muscular Atrophy (SMA)

  NCT04139343

  Condition:   Spinal Muscular Atrophy
  Intervention:  
  Sponsor:   Ohio State University
  Recruiting
• Young Adult Congenital Heart Disease Physical Activity Lifestyle Study (YACHD-PALS)

  NCT04135859

  Conditions:   Cardiovascular Disease Other;   Physical Activity
  Interventions:   Behavioral: Physical Activity Lifestyle Intervention;   Behavioral: Physical Activity Monitoring
  Sponsor:   Jamie Jackson
  Enrolling by invitation
• Prevention of OUD: The HOME Project (Housing, Opportunities, Motivation and Engagement)

  NCT04135703

  Condition:   Substance Use
  Intervention:   Behavioral: SBOA + Housing
  Sponsors:   Ohio State University;   Nationwide Children's Hospital
  Not yet recruiting
• A Study to Assess the Efficacy, Safety and Tolerability of Oral LPCN 1144 in Subjects With Nonalcoholic Steatohepatitis (NASH)

  NCT04134091

  Condition:   Nonalcoholic Steatohepatitis (NASH)
  Interventions:   Drug: LPCN 1144 Formulation A;   Drug: LPCN 1144 Formulation B;   Drug: Placebo
  Sponsor:   Lipocine Inc.
  Recruiting
• Comparative Imaging Assessment of Valvular Heart Disease

  NCT04126018

  Conditions:   Valve Heart Disease;   Aortic Stenosis;   Aortic Regurgitation
  Interventions:   Diagnostic Test: MRI with strain measurement;   Diagnostic Test: Echocardiography
  Sponsor:   The Cleveland Clinic
  Recruiting
• Safety and Efficacy of the Noxsano Wound Care Bandage

  NCT04123093

  Conditions:   Wound Heal;   Peripheral Artery Disease;   Ulcer, Leg;   Ulcer Foot;   Diabetic Foot Ulcer;   Arterial Insufficiency
  Interventions:   Device: Noxsano Bandage (Healthy Volunteers);   Device: Noxsano Bandage (Wound Care)
  Sponsors:   OhioHealth;   Noxsano, Inc.
  Recruiting
• DNA Repair Activity in the Skin of Day and Night Shift Workers

  NCT04122456

  Condition:   Skin Cancer
  Interventions:   Radiation: Ultraviolet B Radiation;   Other: No Ultraviolet B Radiation
  Sponsor:   Jeffrey B. Travers, MD, PhD
  Not yet recruiting
• Objective Quality of Life Detection Validation

  NCT04121793

  Condition:   Parkinson Disease
  Intervention:   Device: Kinesia 360 and Smartphone sensors
  Sponsors:   Great Lakes NeuroTechnologies Inc.;   National Institute on Minority Health and Health Disparities (NIMHD)
  Recruiting
• Ramucirumab and Pembrolizumab for the Treatment of EGFR Mutant Recurrent or Metastatic Non-small Cell Lung Cancer

  NCT04120454

  Conditions:   Metastatic Lung Non-Small Cell Carcinoma;   Recurrent Lung Non-Small Cell Carcinoma;   Stage IV Lung Cancer AJCC v8;   Stage IVA Lung Cancer AJCC v8;   Stage IVB Lung Cancer AJCC v8
  Interventions:   Biological: Pembrolizumab;   Biological: Ramucirumab
  Sponsors:   Ohio State University Comprehensive Cancer Center;   National Cancer Institute (NCI)
  Not yet recruiting
• A Pilot Study of Collaborative Assessment and Management of Suicidality With Suicidal Children ("CAMS-4Kids")

  NCT04119648

  Conditions:   Suicidal Ideation;   Suicide, Attempted
  Intervention:   Behavioral: CAMS-4Kids
  Sponsors:   Nationwide Children's Hospital;   The Catholic University of America
  Not yet recruiting
• Xylitol - Healthcare Associated Infection Reduction in Stem Cell Transplant Patients

  NCT04117477

  Condition:   Allogeneic Hematopoietic Cell Transplantation
  Interventions:   Drug: Xylitol;   Other: Placebo
  Sponsor:   Children's Hospital Medical Center, Cincinnati
  Recruiting
• Endobronchial Ultrasound-Guided Transbronchial Needle-Aspiration With Suction in Obtaining Samples From Patients With Suspected Nodal Metastatic Lung Cancer

  NCT04116970

  Condition:   Lung Carcinoma
  Interventions:   Procedure: Bronchoscopy;   Procedure: Ultrasound-Guided Transbronchial Needle Aspiration
  Sponsors:   Ohio State University Comprehensive Cancer Center;   National Cancer Institute (NCI)
  Not yet recruiting
• Digital Home Blood Pressure Monitoring in Type B Aortic Dissection Patients

  NCT04116684

  Conditions:   Aortic Dissection;   Hypertension
  Intervention:   Device: Withings Digital Blood Pressure Monitor
  Sponsor:   The Cleveland Clinic
  Recruiting
• Stimulation Combined With Powered Motorized Orthoses for Walking After Stroke

  NCT04116671

  Conditions:   Stroke;   Hemiparesis
  Intervention:   Device: Neuromechanical Gait Assist
  Sponsor:   VA Office of Research and Development
  Not yet recruiting
• Biologically Optimized Infusion Schedule of Gemcitabine and Nab-Paclitaxel for the Treatment of Metastatic Pancreatic Cancer

  NCT04115163

  Conditions:   Metastatic Pancreatic Adenocarcinoma;   Stage IV Pancreatic Cancer AJCC v8
  Interventions:   Drug: Gemcitabine;   Drug: Nab-paclitaxel
  Sponsors:   Laith Abushahin;   National Cancer Institute (NCI)
  Not yet recruiting
• An Open-Label, Multicenter, Phase 1b/2 Study of the Safety and Efficacy of KRT-232 Combined With Low-Dose Cytarabine (LDAC) or Decitabine in Patients With Acute Myeloid Leukemia (AML)

  NCT04113616

  Conditions:   Acute Myeloid Leukemia (AML);   Acute Myeloid Leukemia (AML), Secondary to Myeloproliferative Neoplasms (MPN)
  Interventions:   Drug: KRT-232;   Drug: Cytarabine;   Drug: Decitabine
  Sponsor:   Kartos Therapeutics, Inc.
  Recruiting
• Individualized Exercise Oncology Program for Newly Diagnosed Breast Cancer Patients

  NCT04106609

  Condition:   Breast Cancer
  Interventions:   Other: Supervised, individualized exercise oncology program;   Other: Current standard of care
  Sponsor:   Karen Wonders
  Recruiting
• Validation of a Quality of Life Metric "Prolac-10"

  NCT04106531

  Conditions:   Prolactinoma;   Prolactin-Producing Pituitary Tumor;   Pituitary Tumor;   Prolactinoma Macroadenoma;   Prolactinoma Microadenoma
  Intervention:  
  Sponsor:   Ohio State University
  Not yet recruiting
• Self-Management in Parents of Technology-Dependent Children

  NCT04105244

  Conditions:   Caregivers;   Parents;   Self-Management;   Chronic Illnesses, Multiple
  Intervention:   Behavioral: Resourcefulness Training©
  Sponsor:   University Hospitals Cleveland Medical Center
  Recruiting
• The Natural History of Parkinson's Disease-associated Spinal Disorders

  NCT04101513

  Conditions:   Parkinson Disease;   Idiopathic Parkinson Disease
  Intervention:  
  Sponsor:   Ohio State University
  Recruiting
• Neural Correlates of Knee Sensorimotor Control in Patients With Patelleofemoral Pain Syndrome

  NCT04099004

  Conditions:   Patellofemoral Pain Syndrome;   Patello Femoral Syndrome;   Patellofemoral Syndrome
  Intervention:  
  Sponsor:   Children's Hospital Medical Center, Cincinnati
  Recruiting
• TRANSPIRE: Lung Injury in a Longitudinal Cohort of Pediatric HSCT Patients

  NCT04098445

  Conditions:   Hematopoietic Stem Cell Transplant (HSCT);   Diffuse Alveolar Hemorrhage;   Thrombotic Microangiopathies;   Interstitial Pneumonitis;   Bronchiolitis Obliterans
  Intervention:  
  Sponsor:   Children's Hospital Medical Center, Cincinnati
  Not yet recruiting
• Synbiotic Dietary Supplement and Gut Microbiota

  NCT04097106

  Condition:   Healthy
  Intervention:   Dietary Supplement: Synbiotic
  Sponsor:   The Cleveland Clinic
  Not yet recruiting
• Late Evening and Early Morning Protein Supplement to Reduce Readmissions for Hepatic Encephalopathy

  NCT04096014

  Condition:   Hepatic Encephalopathy
  Interventions:   Dietary Supplement: Ensure Enlive;   Other: Standard Of Care
  Sponsor:   The Cleveland Clinic
  Recruiting
• Sirolimus for Cowden Syndrome With Colon Polyposis

  NCT04094675

  Conditions:   PTEN Gene Mutation;   PTEN Hamartoma Tumor Syndrome;   PTEN Hamartoma Syndrome;   Cowden Syndrome;   Bannayan Syndrome;   Bannayan Zonana Syndrome;   Polyposis
  Intervention:   Drug: Sirolimus
  Sponsors:   Ohio State University;   PTEN Research
  Recruiting
• Hydroxyurea Exposure Limiting Pregnancy and Follow-Up Lactation

  NCT04093986

  Conditions:   Sickle Cell Disease;   Sickle Cell Anemia
  Interventions:   Other: Chart Review;   Other: Survey
  Sponsors:   Children's Hospital Medical Center, Cincinnati;   University of Connecticut;   University of Colorado, Denver;   Guy's and St Thomas' NHS Foundation Trust;   Duke University;   Children's Hospital of Philadelphia
  Recruiting
• Boiled Peanut Oral Immunotherapy

  NCT04090203

  Condition:   Peanut Hypersensitivity
  Intervention:   Drug: Boiled Peanut Powder
  Sponsors:   Alton Melton;   The Cleveland Clinic
  Enrolling by invitation
• Online Acceptance and Commitment Therapy for Chronic Pain in Sample of People With Chiari Malformation

  NCT04089670

  Conditions:   Chronic Pain;   Chiari Malformation
  Intervention:   Behavioral: Online Acceptance and Commitment Therapy Intervention
  Sponsors:   Kent State University;   Utah State University;   Conquer Chiari
  Recruiting
• LDL-Apheresis for FSGS CardioRenal Outcomes

  NCT04088799

  Condition:   Focal Segmental Glomerulosclerosis
  Intervention:   Other: No intervention
  Sponsors:   Children's Hospital Medical Center, Cincinnati;   Kaneka Pharma America LLC
  Enrolling by invitation
• TCRαβ+/CD19+ Depleted Allogeneic Hematopoietic Stem Cell Transplantation for Malignant and Non-malignant Disorders

  NCT04088760

  Condition:   Allogeneic Hematopoietic Cell Transplantation
  Intervention:   Drug: TCRαβ+/CD19+ depleted allogeneic hematopoietic stem cell transplant (HSCT)
  Sponsor:   Children's Hospital Medical Center, Cincinnati
  Recruiting
• Peripheral Blood Mononuclear Cells Response In Healthy Controls, Heavy Drinkers, and Patients With Alcoholic Hepatitis

  NCT04088370

  Condition:   Alcoholic Hepatitis
  Intervention:   Other: Blood Draw
  Sponsor:   The Cleveland Clinic
  Recruiting
• Long-Term Longitudinal QoL in Patients Undergoing EEA

  NCT04087902

  Conditions:   Pituitary Tumor;   Meningioma;   Rathke Cleft Cysts;   Chordoma;   Chondrosarcoma;   Craniopharyngioma;   Encephalocele;   Esthesioneuroblastoma
  Intervention:  
  Sponsor:   Ohio State University
  Recruiting
• Southeast Asian Women's Health Project

  NCT04086771

  Conditions:   Breast Cancer;   Cervical Cancer
  Interventions:   Behavioral: Navigation;   Other: Information only
  Sponsors:   Ohio State University;   University of South Florida;   American Cancer Society, Inc.
  Not yet recruiting
• Teaching Caregivers of Hospice Patients to Administer Reiki

  NCT04086017

  Conditions:   Hospice;   Pain;   Anxiety;   Stress
  Intervention:   Other: Reiki therapy
  Sponsors:   Ohio State University;   OhioHealth
  Not yet recruiting
• Using Augmentative & Alternative Communication to Promote Language Recovery for People With Post-Stroke Aphasia

  NCT04081207

  Conditions:   Post-stroke Aphasia;   Aphasia
  Intervention:   Behavioral: AAC for Language Recovery (AAC-LaRc)
  Sponsors:   University of Cincinnati;   Children's Hospital Medical Center, Cincinnati
  Recruiting
• Inherited and Non-inherited Cardiac Disease Quality of Life

  NCT04080492

  Conditions:   Hypertrophic Obstructive Cardiomyopathy;   Thoracic Aortic Aneurysm;   Heart Disease Caused by Ionising Radiation;   Quality of Life
  Intervention:   Other: QOL Survey
  Sponsor:   The Cleveland Clinic
  Recruiting
• Glycemic Control Based on Serum Fructosamine Concentration vs. hemoglobinA1c (HbA1c) in Diabetic Patients

  NCT04079660

  Condition:   Diabetes
  Intervention:   Diagnostic Test: Capillary blood glucose blood draw
  Sponsor:   Ohio State University
  Active, not recruiting
• High Definition Neuromuscular Stimulation in Tetraplegia

  NCT04075812

  Condition:   Spinal Cord Injury at C4-C6 Level
  Intervention:   Device: Neuromuscular Stimulator
  Sponsor:   Ohio State University
  Completed
• Community Benefit of No-charge Calcium Score Screening Program

  NCT04075162

  Condition:   Cardiovascular Risk Factor
  Intervention:  
  Sponsor:   University Hospitals Cleveland Medical Center
  Recruiting
• A Study of TAK-981 in Combination With Rituximab in Participants With Relapsed/Refractory (r/r) CD20-positive (CD20+) Non-Hodgkin Lymphoma (NHL)

  NCT04074330

  Condition:   Lymphoma, Non-hodgkin
  Interventions:   Drug: TAK-981;   Drug: Rituximab
  Sponsor:   Millennium Pharmaceuticals, Inc.
  Recruiting
• Mesenchymal Stem Cells for the Treatment of Pouch Fistulas in Crohn's

  NCT04073472

  Conditions:   Crohn's Disease;   Fistula;   Anal Fistula;   Pouch, Ileal;   Pouches, Ileoanal
  Intervention:   Drug: mesenchymal stem cells (MSCs)
  Sponsor:   The Cleveland Clinic
  Not yet recruiting
• Neuroplastic Mechanisms Underlying Augmented Neuromuscular Training

  NCT04069520

  Condition:   Anterior Cruciate Ligament Injuries
  Interventions:   Other: Augmented biofeedback;   Other: Sham comparator
  Sponsor:   Children's Hospital Medical Center, Cincinnati
  Recruiting
• Comparison of Lithotripsy Urolithiasis Machines

  NCT04069338

  Conditions:   Kidney Stone;   Kidney Calculi;   Ureteral Calculi;   Ureterolithiasis;   Urolithiasis
  Intervention:   Procedure: Lithotripter
  Sponsor:   The Cleveland Clinic
  Recruiting
• Standard vs Mini-PCNL for the Treatment of Stone Disease

  NCT04069013

  Conditions:   Urolithiasis;   Kidney Stone;   Kidney Calculi;   Ureteral Calculi;   Kidney Diseases
  Intervention:   Procedure: PCNL
  Sponsors:   The Cleveland Clinic;   University of British Columbia;   Massachusetts General Hospital;   Vanderbilt University Medical Center;   Duke University;   Ohio State University;   Columbia University;   Dartmouth-Hitchcock Medical Center
  Not yet recruiting
• Implementation of Multidisciplinary Assessments for Geriatric Patients in an ED Observation Unit

  NCT04068311

  Conditions:   Fall Patients;   Delirium;   Quality of Life;   Functional Status
  Intervention:   Other: Geriatric Screening tools
  Sponsors:   Ohio State University;   National Institute on Aging (NIA)
  Recruiting
• Growth and Tolerance Trial on Infant Formula With HMO

  NCT04066413

  Condition:   Healthy Growth
  Interventions:   Other: Standard infant formula;   Other: Infant formula supplemented with HMO
  Sponsor:   FrieslandCampina
  Recruiting
• Feasibility Study for Intrathoracic Nerve Stimulation

  NCT04066374

  Condition:   Postoperative Pain
  Intervention:   Device: Peripheral Nerve Stimulation
  Sponsor:   The Cleveland Clinic
  Recruiting
• A Dietary Intervention Study on the Microbiome in Crohn's Disease Patients

  NCT04065048

  Condition:   Crohn Disease
  Intervention:   Other: Soy based diet
  Sponsors:   Case Western Reserve University;   University of California, Davis;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   University Hospitals Cleveland Medical Center
  Not yet recruiting
• Virtual Visits to Optimize Research Trial Offerings to HF Patients

  NCT04064541

  Conditions:   Heart Failure, Systolic;   Heart Failure With Preserved Ejection Fraction
  Intervention:   Other: Virtual Visit
  Sponsor:   The Cleveland Clinic
  Recruiting
• Evaluation of Perforator Phase Contrast Angiography in Developing Surgery Plans for Patients With Breast Cancer Undergoing Breast Reconstruction With Free-Flap Methods After Mastectomy

  NCT04063410

  Condition:   Mammoplasty Patient
  Interventions:   Procedure: Angiography;   Procedure: MRI-Based Angiogram;   Other: Quality-of-Life Assessment
  Sponsors:   Ohio State University Comprehensive Cancer Center;   National Cancer Institute (NCI)
  Not yet recruiting
• Persistent Postpartum Cardiovascular Dysfunction in Patients With Preeclampsia

  NCT04063397

  Conditions:   Preeclampsia;   Preeclampsia Severe;   Cardiac Complication
  Interventions:   Diagnostic Test: Echocardiogram;   Diagnostic Test: Blood draw
  Sponsors:   Ohio State University;   Roche Diagnostics
  Recruiting
• SAGE for the Early Detection of Cognitive Impairment at Primary Care Provider Visits

  NCT04063371

  Condition:   Cognitive Impairment
  Interventions:   Other: Self-Administered Gerocognitive Examination (SAGE) or Electronic Self-Administered Gerocognitive Examination (eSAGE);   Other: Informant Conversation
  Sponsor:   Ohio State University
  Not yet recruiting
• Minimal Occlusive Pressure With Cuffed ETTs: The Effect of 3 Different Sizes of cETT on Intracuff Pressure in Children

  NCT04061629

  Condition:   Surgical Procedure, Unspecified
  Intervention:   Device: Cuffed ETT
  Sponsor:   Nationwide Children's Hospital
  Enrolling by invitation
• A Study to Evaluate the Long Term Safety of OTX-TP (Sustained Release Travoprost) Intracanalicular Insert

  NCT04061044

  Condition:   Open Angle Glaucoma and Ocular Hypertension
  Intervention:   Drug: Ophthalmic Insert
  Sponsor:   Ocular Therapeutix, Inc.
  Active, not recruiting
• Fecal Microbiota Transplantation For The Treatment Of Gastro-Intestinal Acute GVHD

  NCT04059757

  Condition:   Gastro-Intestinal Acute Graft Versus Host Disease (GI-aGVHD)
  Intervention:   Biological: Fecal Microbiota Transplantation (FMT)
  Sponsor:   Leland Metheny
  Not yet recruiting
• Building Family Caregiver Skills Using a Simulation-Based Intervention for Care of Cancer Patients

  NCT04055948

  Condition:   Cancer
  Interventions:   Behavioral: One-on-one teaching sessions;   Behavioral: Telephone booster contact
  Sponsor:   Case Comprehensive Cancer Center
  Not yet recruiting
• The Effect of the Low Fodmap Diet in Children With Autism Spectrum Disorders

  NCT04054349

  Condition:   Autism Spectrum Disorder
  Intervention:   Other: Low FODMAP diet
  Sponsor:   Ohio State University
  Completed
• Regorafenib in Bevacizumab Refractory Recurrent Glioblastoma

  NCT04051606

  Condition:   Recurrent Glioblastoma
  Intervention:   Drug: Regorafenib
  Sponsor:   Case Comprehensive Cancer Center
  Recruiting
• Effect of a Vibratory Stimulus on Mitigating Nociception-specific Responses to Skin Puncture in Neonates

  NCT04050384

  Conditions:   Infant, Newborn;   Infant, Premature;   Pain Perception;   Pain Measurement;   Pain Management;   Electroencephalography
  Intervention:   Device: Baby GentleStick
  Sponsor:   Lance Relland
  Recruiting
• Vyxeos for Re-induction Treatment of Acute Myeloid Leukemia Patients With Persistent Disease After Induction

  NCT04049539

  Conditions:   Blasts More Than 5 Percent of Bone Marrow Nucleated Cells;   Persistent Disease;   Refractory Acute Myeloid Leukemia
  Intervention:   Drug: Liposome-encapsulated Daunorubicin-Cytarabine
  Sponsors:   Ohio State University Comprehensive Cancer Center;   National Cancer Institute (NCI)
  Not yet recruiting
• Clinical and Radiological Outcomes of Posterior Cervical Fusion Supplemented With Interfacet Spacers

  NCT04041583

  Condition:   Cervical Fusion
  Intervention:   Device: Cervical Interfacet Spacers
  Sponsors:   Ohio State University;   Medtronic
  Recruiting
• Healthy Eating, Activity and Reduction of Teen Stress

  NCT04038684

  Conditions:   Overweight and Obesity;   Overweight Adolescents;   Emotional Stress;   Stress, Psychological;   Eating Behavior
  Interventions:   Behavioral: Mindfulness-Based Weight Control (MBWC);   Behavioral: Standard Behavioral Weight Control (SBWC)
  Sponsors:   Kent State University;   Case Western Reserve University;   The Miriam Hospital;   Brown University;   Rhode Island Hospital;   University of North Carolina, Chapel Hill
  Recruiting
• Triamcinolone With Vitamin D Synergistic Efficacy in Psoriasis

  NCT04036188

  Conditions:   Plaque Psoriasis;   Vitamin D3
  Interventions:   Drug: Triamcinolone;   Dietary Supplement: Vitamin D3;   Drug: Placebo
  Sponsor:   Wright State Physicians
  Not yet recruiting
• Comprehensive Study of Post-surgical Pain After Pectus or Spine Surgery

  NCT04031716

  Conditions:   Pain, Postoperative;   Excavatum, Pectus;   Scoliosis Idiopathic
  Intervention:   Behavioral: Meditation
  Sponsor:   Children's Hospital Medical Center, Cincinnati
  Enrolling by invitation
• Randomized Trial of LENA Home in A Home Visiting Program

  NCT04031326

  Conditions:   Parent-Child Relations;   Language Development
  Intervention:   Behavioral: LENA Home
  Sponsors:   Children's Hospital Medical Center, Cincinnati;   Every Child Succeeds;   The Carol Ann and Ralph V. Haile, Jr./U.S. Bank Foundation;   Bethesda, Inc.
  Recruiting
• Comparing Children's Books to Brochures for Safe Sleep and Infant Reading Education During Prenatal Care

  NCT04031235

  Conditions:   Sudden Unexplained Infant Death;   Child Rearing;   Literacy
  Interventions:   Behavioral: Sleep Baby, Safe and Snug;   Behavioral: Read Baby, Every Day
  Sponsors:   Children's Hospital Medical Center, Cincinnati;   The DeCavel Family SIDS Foundation
  Recruiting
• Corneal Oxygen Uptake With Apioc Contact Lenses

  NCT04031118

  Condition:   Contact Lens-Induced Corneal Disorder of Both Eyes (Diagnosis)
  Intervention:   Device: Apioc Contact Lens
  Sponsor:   Lentechs, LLC
  Enrolling by invitation
• Improving Print Knowledge for Children With Hearing Loss

  NCT04027881

  Condition:   Hearing Loss
  Intervention:   Behavioral: Sit Together and REad
  Sponsor:   Ohio State University
  Not yet recruiting
• Targeted Breast Milk Fortification for Very Low Birth Weight Infants in the NICU

  NCT04025021

  Conditions:   Human Milk;   Neonate;   Breast Milk
  Interventions:   Dietary Supplement: Targeted Fortification;   Device: The Miris Human Milk Analyzer
  Sponsor:   MetroHealth Medical Center
  Enrolling by invitation
• Sequential Hypo- and Normo-thermic Perfusion to Preserve Extended Criteria Donor Livers for Transplantation

  NCT04023773

  Condition:   Liver Transplantation
  Intervention:   Device: Liver Machine Perfusion (MP) device
  Sponsor:   The Cleveland Clinic
  Not yet recruiting
• Myeloid-Derived Suppressor Cell Function in Breast Cancer Patients

  NCT04022616

  Condition:   Breast Cancer
  Intervention:   Other: Specimen collection
  Sponsors:   Ohio State University Comprehensive Cancer Center;   National Cancer Institute (NCI)
  Recruiting
• The Effects of Oscillating-Rotating Electric Toothbrushes on Plaque and Gingival Health

  NCT04017507

  Conditions:   Gingivitis;   Plaque
  Interventions:   Device: Oscillating-rotating electric toothbrush;   Device: Side-to-side electric toothbrush;   Device: Manual toothbrush
  Sponsor:   Procter and Gamble
  Completed
• Human-Animal Interaction to Promote Recovery Following Pediatric Brain Injury

  NCT04016961

  Conditions:   Brain Injuries;   Acquired Brain Injury;   Traumatic Brain Injury
  Interventions:   Other: AAT - Dog;   Other: TAU - No Dog
  Sponsors:   Children's Hospital Medical Center, Cincinnati;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
  Not yet recruiting
• Feasibility of Action Observation and Repetitive Task Practice on Upper Extremity Outcomes in Chronic Stroke Survivors

  NCT04015271

  Conditions:   Stroke;   Hemiparesis
  Interventions:   Behavioral: Action Observation + Repetitive Task Practice;   Behavioral: Placebo Video + Repetitive Task Practice
  Sponsor:   Ohio State University
  Recruiting
• Study of Pembrolizumab Plus SurVaxM for Glioblastoma at First Recurrence

  NCT04013672

  Condition:   Recurrent Glioblastoma
  Interventions:   Drug: Pembrolizumab;   Drug: SurVaxM;   Drug: Sargramostim;   Drug: Montanide ISA 51
  Sponsor:   Manmeet Ahluwalia, MD
  Not yet recruiting
• Targeted Therapy With CDK4/6 Inhibitors in Chemo-Refractory, Rb Wild-Type Extensive SCLC

  NCT04010357

  Condition:   Small-cell Lung Cancer
  Intervention:   Drug: Abemaciclib,
  Sponsor:   Case Comprehensive Cancer Center
  Not yet recruiting
• Anterior Gastropexy vs. No Anterior Gastropexy for Paraesophageal Hernia Repair

  NCT04007952

  Conditions:   Paraesophageal Hernia;   Hiatal Hernia Large
  Intervention:   Procedure: Anterior Gastropexy
  Sponsor:   The Cleveland Clinic
  Recruiting
• Single-Armed Use of ViviGen Cellular Bone Matrix in Patients Undergoing Posterolateral Lumbar Surgery

  NCT04007094

  Conditions:   Degenerative Disc Disease;   Spinal Stenosis;   Spondylosis;   Spondylolisthesis
  Intervention:   Drug: ViviGen Cellular Bone Matrix
  Sponsors:   Ohio State University;   DePuy Synthes
  Recruiting
• Meta-analysis of Stannous Fluoride and the Effects on Dental Plaque

  NCT04006483

  Condition:   Dental Plaque
  Interventions:   Drug: Stannous fluoride dentifrice;   Drug: Positive control dentifrice;   Drug: Negative control dentifrice
  Sponsor:   Procter and Gamble
  Completed
• Meta-analysis of Stannous Fluoride and the Effects on Enamel Erosion

  NCT04006470

  Condition:   Enamel Erosion
  Interventions:   Drug: Stannous fluoride dentifrice;   Drug: Positive control dentifrice;   Drug: Negative control dentifrice
  Sponsor:   Procter and Gamble
  Completed
• Meta-analysis of Stannous Fluoride Dentifrice and the Effects on Dentine Hypersensitivity

  NCT04005417

  Condition:   Dentine Hypersensitivity
  Interventions:   Drug: Stannous fluoride dentifrice;   Drug: Positive control dentifrice;   Drug: Negative control dentifrice
  Sponsor:   Procter and Gamble
  Completed
• Tracking Device Guided Feedback to Enhance Patient Physician Interaction

  NCT04004806

  Conditions:   Physician Patient Relation;   Burnout, Professional
  Intervention:   Device: Hill Rom tracking device
  Sponsors:   The Cleveland Clinic;   Accreditation Council for Graduate Medical Education
  Enrolling by invitation
• Feasibility of Collecting Stress Biomarkers Among Youth Experiencing Homelessness

  NCT04004520

  Condition:   Stress, Physiological
  Interventions:   Behavioral: Virtual Reality with Meditation;   Behavioral: Audio Control;   Behavioral: Virtual reality Control
  Sponsor:   Ohio State University
  Recruiting
• Laser Cell Therapy for Knee Cartilage Repair

  NCT04001361

  Condition:   Knee Osteoarthritis
  Intervention:   Procedure: Laser Cell Therapy
  Sponsor:   Endocellutions
  Not yet recruiting
• Pilot Study of Powered Exoskeleton Use for Gait Rehabilitation in Individuals With Multiple Sclerosis

  NCT04000373

  Conditions:   Multiple Sclerosis;   Gait Disorders, Neurologic
  Intervention:   Device: Ekso GT™ exoskeleton
  Sponsor:   The Cleveland Clinic
  Not yet recruiting
• Pragmatic Cyclical Lower Extremity Exercise Trial for Parkinson's Disease

  NCT04000360

  Condition:   Parkinson Disease
  Intervention:   Other: High-Intensity Aerobic Exercise
  Sponsors:   The Cleveland Clinic;   National Institutes of Health (NIH)
  Recruiting
• S-Nitrosylation (SNO) Therapy During Autologous Blood Transfusion

  NCT03999229

  Condition:   Transfusion Related Complication
  Interventions:   Drug: SNO;   Drug: Normal Saline;   Drug: Red Blood Cell
  Sponsors:   James Reynolds;   Case Western Reserve University;   National Heart, Lung, and Blood Institute (NHLBI)
  Recruiting
• The Effect of Local Analgesia on Postoperative Gluteal Pain in Patients Undergoing Sacrospinous Ligament Fixation: A Randomized Trial

  NCT03995641

  Conditions:   Postoperative Pain;   Pelvic Organ Prolapse;   Trigger Point Injection;   Sacrospinous Ligament Fixation
  Intervention:   Drug: marcaine and kenalog
  Sponsor:   Kettering Health Network
  Recruiting
• ICE T for Post GYN Surgery Pain

  NCT03987022

  Condition:   Opioid Substitution Treatment
  Interventions:   Drug: Ketorolac;   Drug: Opioids;   Other: Ice Packs;   Drug: Tylenol;   Drug: Motrin;   Drug: dilaudid
  Sponsor:   MetroHealth Medical Center
  Recruiting
• A Pilot Study to Assess the Accuracy of Blood Pressure Assessment by the Omron HeartGuide Smartwatch

  NCT03986281

  Conditions:   Hypertension;   Cardiac Disease;   Surgery
  Interventions:   Other: Omron Wearable Device;   Other: Standard Arterial Line
  Sponsor:   The Cleveland Clinic
  Recruiting
• A Single Session Pain Psychology Class for Spine Surgery Patients

  NCT03985436

  Condition:   Lumbar; Injury
  Intervention:   Behavioral: Trek for Surgical Success
  Sponsor:   Sara Davin, PsyD, MPH
  Enrolling by invitation
• Daily Living Skills Intervention for 9th and 10th Graders With Autism Spectrum Disorders

  NCT03984513

  Condition:   Autism Spectrum Disorder
  Interventions:   Behavioral: Surviving and Thriving in the Real World;   Behavioral: Program for the Education and Enrichment of Relational Skills
  Sponsors:   Children's Hospital Medical Center, Cincinnati;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
  Recruiting
• A Program to Increase Sickle Cell Trait Knowledge Among Parent of Infants Identified in Newborn Screening

  NCT03984500

  Condition:   Sickle Cell Trait
  Intervention:   Other: Education
  Sponsors:   Nationwide Children's Hospital;   National Institutes of Health (NIH);   National Heart, Lung, and Blood Institute (NHLBI)
  Recruiting
• Daily Living Skills Intervention for Adolescents With Autism Spectrum Disorder

  NCT03984487

  Condition:   Autism Spectrum Disorder
  Interventions:   Behavioral: Surviving and Thriving in the Real World;   Behavioral: Program for the Education and Enrichment of Relational Skills
  Sponsors:   Children's Hospital Medical Center, Cincinnati;   United States Department of Defense
  Recruiting
• IPACK Versus Popliteal Sciatic Nerve Block in ACL Reconstruction

  NCT03983941

  Condition:   Anterior Cruciate Ligament Tear
  Intervention:   Drug: Ropivacaine injection
  Sponsor:   Sujana Dontukurthy
  Enrolling by invitation
• Efficacy and Application of the Alfred SmartBag System After Ileostomy Creation in Colorectal Surgery: A Pilot Study

  NCT03982875

  Conditions:   Ileostomy - Stoma;   Ileostomy; Complications
  Intervention:   Device: Alfred SmartBag
  Sponsors:   11 Heath and Technologies Limited;   The Cleveland Clinic
  Recruiting
• Innovations to Prevent Relapse Among Low-income African American Smokers

  NCT03982576

  Condition:   Smoking Cessation
  Interventions:   Other: Nicotine replacement therapy (NRT);   Behavioral: CS-CBT intervention;   Behavioral: Path2Quit;   Behavioral: Relapse prevention program;   Behavioral: SmokefreeTXT
  Sponsor:   Case Comprehensive Cancer Center
  Not yet recruiting
• Dietary Supplementation in Heart Failure

  NCT03980574

  Condition:   Heart Failure
  Intervention:   Dietary Supplement: R Drink
  Sponsors:   Ohio State University;   Vascular Scientific, LLC
  Recruiting
• A Pilot Study of KPL-914 in Recurrent Pericarditis

  NCT03980522

  Condition:   Recurrent Pericarditis
  Intervention:   Drug: KPL-914
  Sponsor:   Kiniksa Pharmaceuticals, Ltd.
  Completed
• Trial of Blood Flow Restriction Plus Physical Therapy vs. Physical Therapy Alone for Lateral Epicondylitis

  NCT03978897

  Condition:   Lateral Epicondylitis
  Interventions:   Device: Blood flow restriction tourniquet;   Other: Evidence based physical/occupational therapy
  Sponsor:   Akron General Medical Center
  Recruiting
• Dual-benefits of Aerobic and Resistance Training

  NCT03978572

  Conditions:   Sarcopenia;   Aging;   Disability Physical
  Interventions:   Behavioral: Resistance Training;   Behavioral: Moderate-Intensity Continuous Cycling;   Behavioral: High-Intensity Interval Cycling
  Sponsors:   Ohio University;   American Heart Association
  Recruiting
• Dabrafenib, Trametinib, and IMRT in Treating Patients With BRAF Mutated Anaplastic Thyroid Cancer

  NCT03975231

  Conditions:   BRAF NP_004324.2:p.V600E;   BRAF V600K Mutation Present;   Thyroid Gland Anaplastic Carcinoma
  Interventions:   Drug: Dabrafenib;   Radiation: Intensity-Modulated Radiation Therapy;   Drug: Trametinib
  Sponsors:   Manisha Shah;   National Cancer Institute (NCI)
  Not yet recruiting
• Gut-level Antiinflammatory Activities of Green Tea in Metabolic Syndrome

  NCT03973996

  Conditions:   Dysbiosis;   Endotoxemia;   Metabolic Syndrome;   Inflammation
  Interventions:   Dietary Supplement: Green Tea Extract;   Dietary Supplement: Placebo
  Sponsors:   Ohio State University;   USDA Beltsville Human Nutrition Research Center
  Recruiting
• Parastomal Hernia Repair Utilizing the Retromuscular Sugarbaker Versus Keyhole Mesh Techniques

  NCT03972553

  Condition:   Parastomal Hernia
  Interventions:   Procedure: Sugarbaker technique for repairing parastomal hernia;   Procedure: Keyhole technique for repairing parastomal hernia
  Sponsor:   The Cleveland Clinic
  Recruiting
• A Problem Solving Intervention for Post-ICU Cognitive Impairment in Older Adults

  NCT03972384

  Conditions:   Critical Illness;   Mechanical Ventilation Complication;   Delirium;   Cognitive Impairment
  Intervention:   Behavioral: Post-ICU Problem Solving
  Sponsor:   Ohio State University
  Not yet recruiting
• Meta-analysis of Stannous Fluoride and the Effects on Gingival Health

  NCT03970759

  Condition:   Gingivitis
  Interventions:   Drug: Stannous Fluoride Dentifrice;   Drug: Positive control dentifrice;   Drug: Negative control dentifrice
  Sponsor:   Procter and Gamble
  Completed
• Evaluation of Step-Based Care for Individuals at Clinical High Risk for Psychosis

  NCT03970005

  Condition:   Prodromal Schizophrenia
  Intervention:   Behavioral: Step-Based Care Model
  Sponsors:   Ohio State University;   Substance Abuse and Mental Health Services Administration (SAMHSA)
  Enrolling by invitation
• Oral Ketorolac for Arthroscopic Rotator Cuff Repair

  NCT03967847

  Conditions:   Rotator Cuff Tear;   Postoperative Pain
  Intervention:   Drug: Ketorolac
  Sponsor:   University Hospitals Cleveland Medical Center
  Recruiting
• TRPV2 Agonists in the Fontan Circulation

  NCT03965351

  Condition:   Fontan
  Intervention:   Drug: Probenecid
  Sponsors:   Children's Hospital Medical Center, Cincinnati;   American Heart Association
  Active, not recruiting
• Kidney Fibrosis and MRI

  NCT03964948

  Condition:   Kidney Diseases
  Intervention:   Diagnostic Test: Kidney MRI
  Sponsor:   Children's Hospital Medical Center, Cincinnati
  Recruiting
• Effect of One-lung Ventilation on BIS Values

  NCT03962036

  Conditions:   Surgery;   Thoracic
  Intervention:   Device: Bispectral index monitor
  Sponsor:   Christopher McKee
  Enrolling by invitation
• Cancer Activity and Lifestyle Measurement Study

  NCT03961685

  Condition:   Breast Cancer
  Intervention:  
  Sponsor:   Ohio State University
  Recruiting
• Glycemic Characterization and Pancreatic Imaging Correlates in Cystic Fibrosis

  NCT03961516

  Conditions:   Cystic Fibrosis;   Cystic Fibrosis-related Diabetes;   Cystic Fibrosis Liver Disease;   Pancreatic Steatosis;   Hepatic Steatosis
  Interventions:   Device: Frequently Sampled Oral Glucose Tolerance Test and CGM;   Radiation: MRI Pancreas and Liver
  Sponsor:   University Hospitals Cleveland Medical Center
  Recruiting
• Gadoxetate Sodium Enhanced MRI as a Biomarker for Aggressive Prostate Cancer

  NCT03960788

  Conditions:   Cancer of the Prostate;   Castration-resistant Prostate Cancer
  Intervention:   Drug: Gadoxetate Sodium
  Sponsor:   University of Cincinnati
  Recruiting
• Photodynamic Therapy and Microvesicles

  NCT03960125

  Conditions:   Photodynamic Therapy;   Microvesicle Particle
  Interventions:   Device: Photodynamic Therapy;   Drug: 4% Imipramine;   Drug: Base Cream
  Sponsor:   Jeffrey B. Travers, MD, PhD
  Not yet recruiting
• Sub-Dissociative Ketamine and Fentanyl to Treat Moderate to Severe Pain

  NCT03959852

  Condition:   Pain, Acute
  Interventions:   Drug: Fentanyl;   Combination Product: Fentanyl and Ketamine;   Drug: Ketamine
  Sponsor:   Mercy Health Ohio
  Recruiting
• Behavioral Economics and Adherence in Teens (BEAT!)

  NCT03958331

  Conditions:   Epilepsy;   Adherence, Medication
  Interventions:   Behavioral: Automated Digital Reminders;   Behavioral: Individualized Adherence Feedback Report;   Behavioral: Individual Adherence Feedback Report with Social Norms
  Sponsors:   Children's Hospital Medical Center, Cincinnati;   National Institute of Nursing Research (NINR);   Nationwide Children's Hospital
  Not yet recruiting
• OT Via Telehealth (ASD and ADHD)

  NCT03957993

  Conditions:   Autism Spectrum Disorder;   Attention Deficit Hyperactivity Disorder
  Interventions:   Other: Occupational Therapy via Telehealth;   Other: Standard of Care Occupational Therapy
  Sponsor:   Children's Hospital Medical Center, Cincinnati
  Recruiting
• Remote Access: Cortical Visual Impairment

  NCT03957980

  Condition:   Cortical Visual Impairment
  Intervention:   Other: Occupational therapy
  Sponsor:   Children's Hospital Medical Center, Cincinnati
  Completed
• CPX-351 Therapy for MDS After Hypomethylating Agent Failure

  NCT03957876

  Condition:   Myelodysplastic Syndrome (MDS)
  Intervention:   Drug: CPX-351
  Sponsor:   Case Comprehensive Cancer Center
  Recruiting
• Evaluation of the Prenatal Trip Assistance Pilot Project

  NCT03956810

  Conditions:   Pregnancy Preterm;   Infant Death
  Interventions:   Other: On-demand transportation;   Other: Usual transportation
  Sponsor:   Ohio State University
  Recruiting
• Cardiovascular Outcomes in Bariatric Surgery Patients With Type 2 Diabetes

  NCT03955952

  Conditions:   Obesity;   Type2 Diabetes;   Bariatric Surgery Candidate
  Intervention:   Procedure: Bariatric Surgery
  Sponsor:   The Cleveland Clinic
  Enrolling by invitation
• AveXis Managed Access Program Cohort for Access to AVXS-101

  NCT03955679

  Condition:   Spinal Muscular Atrophy
  Intervention:   Genetic: AVXS-101
  Sponsors:   United BioSource Corporation;   AveXis, Inc.
  Approved for marketing
• Healthy Relationships Training Study: A Comparison of Interventions to Reduce Dating Violence on College Campuses

  NCT03950128

  Condition:   Dating Violence
  Interventions:   Behavioral: Mindfulness-Based Skills Training (MBST);   Behavioral: Psychoeducational
  Sponsor:   Kent State University
  Completed
• Free Flap Breast Reconstruction Using Virtual Surgical Planning and 3-D Modeling

  NCT03949491

  Condition:   Breast Reconstruction
  Intervention:   Procedure: 3D medical models
  Sponsor:   Case Comprehensive Cancer Center
  Not yet recruiting
• Ultrasound Assessment of the Inferior Vena Cava in Children

  NCT03948282

  Condition:   Surgery
  Intervention:  
  Sponsor:   Alok Moharir
  Completed
• Efficacy of Baricitinib In Treatment of Delayed-Type Hypersensitivity Versus Irritant Skin Reactions in Healthy Adult Male Subjects

  NCT03945760

  Condition:   Allergic Contact Dermatitis
  Interventions:   Drug: Baricitinib;   Drug: Placebo
  Sponsor:   Wright State Physicians
  Not yet recruiting
• CT-P13 (Infliximab) Subcutaneous Administration in Patients With Moderately to Severely Active Crohn's Disease

  NCT03945019

  Condition:   Crohn's Disease
  Interventions:   Biological: CT-P13 SC (Infliximab);   Other: Placebo SC
  Sponsor:   Celltrion
  Recruiting
• Ibrutinib and Venetoclax in Treating Patients With Chronic Lymphocytic Leukemia After Ibrutinib Resistance

  NCT03943342

  Conditions:   Chronic Lymphocytic Leukemia;   Loss of Chromosome 17p
  Interventions:   Drug: Ibrutinib;   Drug: Venetoclax
  Sponsors:   Kerry Rogers;   National Cancer Institute (NCI);   Janssen Research & Development, LLC
  Not yet recruiting
• Proton Accelerated Partial Breast Irradiation

  NCT03940248

  Condition:   Breast Cancer
  Intervention:   Radiation: Proton Accelerated Partial Breast Irradiation
  Sponsor:   University of Cincinnati
  Enrolling by invitation
• Preemptive Infusion of Donor Lymphocytes Depleted of TCR + T Cells + CD19+ B Cells Following ASCT

  NCT03939585

  Conditions:   Allogeneic Stem Cell Transplant Candidate;   Acute Myeloid/Lymphoblastic Leukemia;   Myelodysplastic Syndrome;   Myeloproliferative Neoplasm;   Lymphoproliferative Disorders
  Intervention:   Biological: Cellular therapy product
  Sponsor:   Case Comprehensive Cancer Center
  Not yet recruiting
• Randomized Control Trial Comparing Transfascial Suture for Mesh Fixation to No Mesh Fixation

  NCT03938688

  Conditions:   Ventral Hernia;   Incisional Hernia
  Intervention:   Procedure: Mesh placement with Transfascial Sutures
  Sponsor:   The Cleveland Clinic
  Recruiting
• The Renin-Angiotensin-Aldosterone System in Adiposity, Blood Pressure and Glucose in African Americans

  NCT03938389

  Conditions:   PreDiabetes;   Impaired Glucose Tolerance;   Obesity;   Blood Pressure
  Interventions:   Drug: Sacubitril-Valsartan Tab 97-103 MG;   Drug: Valsartan 160mg;   Drug: Placebo Oral Tablet
  Sponsors:   Ohio State University;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
  Not yet recruiting
• Calcitonin Pre-treatment to Improve SPECT-CT Sensitivity

  NCT03935984

  Conditions:   Primary Hyperparathyroidism;   Hypercalcemia
  Intervention:   Drug: Calcitonin
  Sponsors:   ProMedica Health System;   University of Toledo Health Science Campus
  Recruiting
• Motivational Interviewing and Vaccine Hesitancy in Children

  NCT03934008

  Condition:   Vaccine Hesitancy
  Intervention:   Other: MOtivational interviewing Tool to Improve Vaccine AdherencE (MOTIVE)
  Sponsors:   Cedarville University;   Merck Investigator Studies Program;   Rocking Horse Community Health Center
  Recruiting
• Study Assessing Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MGTA-145 in Healthy Volunteers as a Single Agent or in Combination With Plerixafor

  NCT03932864

  Condition:   Healthy Volunteers
  Interventions:   Biological: MGTA-145;   Biological: plerixafor;   Biological: Placebo
  Sponsor:   Magenta Therapeutics, Inc.
  Recruiting
• Gene Expression Changes In Young and Geriatric Skin

  NCT03932162

  Conditions:   UVB Phototherapy Burn;   Insulin-like Growth Factor 1;   Aging
  Interventions:   Drug: Insulin-Like Growth Factor 1;   Other: No Insulin-Lie Growth Factor 1
  Sponsor:   Jeffrey B. Travers, MD, PhD
  Recruiting
• Collaborating to Implement Cross-System Interventions in Child Welfare and Substance Use

  NCT03931005

  Conditions:   Substance Use;   Implementation;   Child Maltreatment;   System Fragmentation
  Interventions:   Other: Collaboration Decision Support Guide;   Other: General Collaboration Support
  Sponsor:   Ohio State University
  Not yet recruiting
• 18F-Fluciclovine PET to Distinguish Tumor Progression From Radiation Necrosis

  NCT03930173

  Condition:   Secondary Malignant Neoplasm of Brain and Cerebral Meninges
  Interventions:   Drug: 18F-fluciclovine;   Device: PET/CT of the brain
  Sponsor:   Case Comprehensive Cancer Center
  Recruiting
• Liposomal Bupivacaine Versus Interscalene Nerve Block

  NCT03929146

  Condition:   Pain, Postoperative
  Interventions:   Drug: Exparel;   Procedure: Interscalene Nerve Block
  Sponsor:   University of Cincinnati
  Recruiting
• Feasibility of a Culturally-Specific Video Text Cessation Intervention With AA Quitline Callers

  NCT03927976

  Condition:   Tobacco Use Cessation
  Intervention:   Behavioral: Path2Quit - culturally specific text message intervention
  Sponsor:   Case Comprehensive Cancer Center
  Not yet recruiting
• GSNOR Phenotyping/GSNO Challenge

  NCT03926741

  Conditions:   Asthma;   Healthy Volunteers
  Intervention:   Drug: GSNO
  Sponsors:   James Reynolds;   University Hospitals Cleveland Medical Center;   Case Western Reserve University;   National Heart, Lung, and Blood Institute (NHLBI)
  Recruiting
• Screening for Systemic Amyloidosis Via the Ligamentum Flavum

  NCT03923920

  Conditions:   Amyloid;   Amyloidosis;   Spinal Stenosis;   Transthyretin Amyloidosis;   Primary Amyloidosis of Light Chain Type
  Intervention:   Procedure: Biopsy
  Sponsor:   The Cleveland Clinic
  Recruiting
• Pelvic Floor Muscle Training With Leva System for Urge Incontinence

  NCT03923348

  Conditions:   Overactive Bladder;   Urge Urinary Incontinence;   Mixed Urinary Incontinence
  Intervention:   Device: Leva device
  Sponsors:   The Christ Hospital;   Renovia, Inc.
  Recruiting
• Study of the Safety and Efficacy of DPI-386 Nasal Gel on Ocean-Going Vessels

  NCT03920644

  Conditions:   Prevention of Nausea Associated With Motion Sickness;   Treatment of Nausea Associated With Motion Sickness
  Interventions:   Drug: Scopolamine Transdermal Patch [Transderm Scop];   Drug: Scopolamine;   Drug: Placebo Patch;   Drug: Placebo Gel
  Sponsor:   Naval Aeromedical Research Unit, Dayton
  Recruiting
• A Clinical Study of the Eztetic Dental Implant System

  NCT03917927

  Condition:   Edentulous Jaw
  Intervention:   Device: Eztetic dental implant
  Sponsor:   Zimmer Biomet
  Recruiting
• Older Adult Effectiveness of 2 Treatments

  NCT03916926

  Condition:   Dental Caries
  Interventions:   Device: A "simple medical strategy" consisting of silver diamine fluoride (SDF);   Device: B "typical dental strategy" consisting of atraumatic restorative treatment (ART) with glass ionomer cement + Fluoride varnish (FV)
  Sponsors:   Case Western Reserve University;   Patient-Centered Outcomes Research Institute
  Not yet recruiting
• Registry and Screening Tool to Identify Children With Asthma Likely to Benefit From Home Assessment and Remediation

  NCT03916237

  Conditions:   Asthma;   Pediatric ALL;   School Health Services;   Registries;   Medical Informatics;   Home Visits;   Housing Problems;   Social Determinants of Health;   Healthcare Disparity;   Health Status Disparity
  Interventions:   Other: Home assessment;   Other: Home remediation;   Other: Referral to Medical Legal Partnership;   Other: Asthma SDH screening tool
  Sponsors:   MetroHealth Medical Center;   Cleveland Metropolitan School District;   Environmental Health Watch;   Legal Aid Society of Cleveland
  Not yet recruiting
• Fuzzy AI Using VR for Collision Prevention

  NCT03915119

  Condition:   Injuries
  Intervention:   Other: GFT AI training
  Sponsor:   Children's Hospital Medical Center, Cincinnati
  Active, not recruiting
• Fontan Associated Liver Disease

  NCT03914196

  Condition:   Fontans
  Intervention:   Diagnostic Test: Liver Stiffness Ultrasound
  Sponsor:   Children's Hospital Medical Center, Cincinnati
  Recruiting
• Effects of Neuromuscular Training on EEG Adaptations in Young Athletes

  NCT03913975

  Condition:   Brain Concussion
  Intervention:   Other: Neuromuscular training
  Sponsor:   Children's Hospital Medical Center, Cincinnati
  Completed
• Hemoglobin Desaturation in Sickle Cell Disease

  NCT03908385

  Condition:   Sickle Cell Disease
  Intervention:  
  Sponsor:   University Hospitals Cleveland Medical Center
  Recruiting
• Liposomal Bupivacaine After Cesarean Delivery

  NCT03907813

  Conditions:   Pain, Postoperative;   Opioid Use
  Interventions:   Drug: Exparel;   Other: Saline infiltration
  Sponsor:   Wright State University
  Not yet recruiting
• Advance Care Planning GuideTailored for Primary Care Patients

  NCT03906773

  Conditions:   Advance Care Planning;   Chronic Disease;   Communication Research
  Intervention:   Other: Patient Centered Medical Home Based Electronic Framework for Advance Care Planning
  Sponsor:   Ohio State University
  Completed
• Effectiveness of Fractionated Laser Resurfacing to Protect Geriatric Skin From Actinic Neoplasia

  NCT03906253

  Conditions:   Actinic Keratoses;   Aging;   Non-Melanoma Skin Cancer
  Intervention:   Device: Fractionated Laser Resurfacing
  Sponsor:   Jeffrey B. Travers, MD, PhD
  Recruiting
• Identification of microRNAs Involved in Cerebral Collateral Regulation

  NCT03905434

  Condition:   Cerebrovascular Disorders
  Intervention:   Genetic: miRNA sampling
  Sponsor:   Ohio State University
  Recruiting
• Defining the Operating Characteristics of NIRS in the Diagnosis of Pediatric Traumatic Intracranial Hemorrhage

  NCT03905031

  Conditions:   Craniocerebral Injuries;   Head Injuries;   Head Injury, Minor;   Head Trauma;   Traumatic Brain Injury;   Traumatic Brain Hemorrhage;   Hematoma of Head;   Intracranial Hemorrhages
  Intervention:   Device: InfraScanner 2000
  Sponsor:   Dayton Children's Hospital
  Recruiting
• Testing the Safety and Tolerability of CX-4945 in Patients With Recurrent Medulloblastoma Who May or May Not Have Surgery

  NCT03904862

  Condition:   Medulloblastoma, Childhood
  Intervention:   Drug: CX 4945
  Sponsors:   Pediatric Brain Tumor Consortium;   St. Jude Children's Research Hospital;   National Cancer Institute (NCI)
  Recruiting
• Post-partum Non-pharmacologic Pain Management

  NCT03903172

  Conditions:   Pain Management;   Vaginal Delivery
  Intervention:   Device: Abdominal binder
  Sponsor:   Wright State University
  Enrolling by invitation
• Optical Treatment of Migraines Using the Avulux™ Optical Filter in the Form of Spectacle Lenses.

  NCT03902496

  Condition:   Migraine
  Interventions:   Other: HIT-6 Questionnaire;   Device: Avulux Spectacles;   Device: Sham Spectacles
  Sponsor:   Avulux, Inc.
  Completed
• A Protein-sparing Modified Fast for Children and Adolescents With Severe Obesity (PSMF)

  NCT03899311

  Condition:   Obesity, Childhood
  Intervention:   Other: protein-sparing modified fast diet
  Sponsor:   Ihuoma Eneli
  Completed
• An Early Feasibility Study of the ReHAB System

  NCT03898804

  Condition:   Tetraplegia
  Intervention:   Device: BCI and FES
  Sponsor:   Jonathan Miller, MD
  Recruiting
• The Effect of Psychologically Informed Education in Adolescents With Anterior Knee Pain

  NCT03897907

  Conditions:   Patellofemoral Pain Syndrome;   Anterior Knee Pain Syndrome
  Interventions:   Other: Psychologically Informed Education Video;   Other: Anatomy Education Video
  Sponsor:   Nationwide Children's Hospital
  Recruiting
• Safety & Immunogenicity Study of Ad5 Based Oral Norovirus Vaccines

  NCT03897309

  Condition:   Norovirus Infection
  Interventions:   Biological: VXA-G1.1-NN;   Biological: VXA-G2.4-NS;   Biological: Placebo Tablets
  Sponsor:   Vaxart
  Recruiting
• Efficacy and Safety of Tildrakizumab in the Treatment of Scalp Psoriasi

  NCT03897088

  Condition:   Scalp Psoriasis
  Interventions:   Drug: Tildrakizumab;   Drug: Placebo
  Sponsor:   Sun Pharma Global FZE
  Recruiting
• Supermarket and Web-Based Intervention Targeting Nutrition (SuperWIN) for Cardiovascular Risk Reduction

  NCT03895580

  Conditions:   Obesity;   Hypertension;   Hyperlipidemias;   Diet Modification
  Interventions:   Other: In-store POP education;   Other: Online POP education
  Sponsors:   University of Cincinnati;   The Kroger Company;   Children's Hospital Medical Center, Cincinnati
  Recruiting
• Use of Lumbar Motion Monitor to Predict Response to Radiofrequency Ablation After Medial Branch Diagnostic Blocks

  NCT03894319

  Condition:   Back Pain
  Intervention:  
  Sponsor:   Ohio State University
  Recruiting
• Database Of Clinical Data For Individuals With Variants In The IRF2BPL Gene

  NCT03892798

  Conditions:   Neurodevelopmental Regression, Seizures, Autism and Developmental Delay (NEDAMSS);   Autism Spectrum Disorder;   Movement Disorders;   Seizures;   Dystonia
  Intervention:   Other: No interventions are planned
  Sponsor:   Children's Hospital Medical Center, Cincinnati
  Recruiting
• Duvelisib and Nivolumab in Treating Patients With Richter Syndrome or Transformed Follicular Lymphoma

  NCT03892044

  Conditions:   Chronic Lymphocytic Leukemia;   Recurrent Diffuse Large B-Cell Lymphoma;   Refractory Diffuse Large B-Cell Lymphoma;   Richter Syndrome;   Small Lymphocytic Lymphoma;   Transformed Chronic Lymphocytic Leukemia to Diffuse Large B-Cell Lymphoma;   Transformed Follicular Lymphoma to Diffuse Large B-Cell Lymphoma;   Transformed Small Lymphocytic Lymphoma to Diffuse Large B-Cell Lymphoma
  Interventions:   Drug: Duvelisib;   Biological: Nivolumab
  Sponsors:   Jennifer Woyach;   National Cancer Institute (NCI)
  Recruiting
• Intestinal Microbiome Composition in Infants With Biliary Atresia (BA)

  NCT03890536

  Conditions:   Biliary Atresia;   Intrahepatic Cholestases;   Normal Controls
  Intervention:  
  Sponsors:   Children's Hospital Medical Center, Cincinnati;   Wuhan Union Hospital, China
  Not yet recruiting
• Phase IB Metformin, Digoxin, Simvastatin in Solid Tumors

  NCT03889795

  Conditions:   Advanced Pancreatic Cancer;   Advanced Solid Tumor
  Interventions:   Drug: Metformin;   Drug: Simvastatin;   Drug: Digoxin
  Sponsor:   John Nemunaitis, MD
  Recruiting
• Study of Ketorolac Versus Opioid for Pain After Endoscopy

  NCT03888144

  Conditions:   Kidney Calculi;   Ureteral Calculi
  Interventions:   Drug: Oxycodone;   Drug: Ketorolac
  Sponsor:   The Cleveland Clinic
  Recruiting
• A Systematic Oral Care Program in Post-Mechanically Ventilated, Post-Intensive Care Patients

  NCT03886623

  Conditions:   Methicillin-resistant Staphylococcus Aureus;   Methicillin-Sensitive Staphylococcus Aureus Infection
  Interventions:   Procedure: 4-day systematic oral hygiene;   Other: Standard of Care oral care
  Sponsor:   Ohio State University
  Completed
• Cardiac Amyloidosis Screening at Trigger Finger Release

  NCT03886155

  Conditions:   Amyloidosis;   Trigger Finger;   Transthyretin Amyloidosis;   Primary Amyloidosis of Light Chain Type
  Intervention:   Procedure: Biopsy
  Sponsor:   The Cleveland Clinic
  Recruiting
• Efficacy of the Dabir Surfaces Micropressure Overlay for Decubitus Ulcer Prevention During Cardiac Surgery

  NCT03884634

  Conditions:   Pressure Ulcer;   Pressure Injury
  Intervention:   Device: Dabir Micropressure Overlay
  Sponsor:   The Cleveland Clinic
  Recruiting
• Cysteamine for Asthma

  NCT03883984

  Condition:   Asthma
  Interventions:   Drug: Cysteamine Bitartrate;   Drug: Placebo Oral Tablet
  Sponsor:   Children's Hospital Medical Center, Cincinnati
  Recruiting
• Donor-Derived Viral Specific T-cells (VSTs) for Prophylaxis Against Viral Infections After Allogeneic Stem Cell Transplant

  NCT03883906

  Conditions:   Allogeneic Stem Cell Transplant;   Viral Infection
  Intervention:   Biological: Viral Specific T-cells (VSTs)
  Sponsors:   Children's Hospital Medical Center, Cincinnati;   Hoxworth Blood Center
  Recruiting