Join Clinical Trials in Ohio

A Study to Evaluate the Long Term Safety of OTX-TP (Sustained Release Travoprost) Intracanalicular Insert
NCT04061044
Condition: Open Angle Glaucoma and Ocular Hypertension
Intervention: Drug: Ophthalmic Insert
Sponsor: Ocular Therapeutix, Inc.
Active, not recruiting
Fecal Microbiota Transplantation For The Treatment Of Gastro-Intestinal Acute GVHD
NCT04059757
Condition: Gastro-Intestinal Acute Graft Versus Host Disease (GI-aGVHD)
Intervention: Biological: Fecal Microbiota Transplantation (FMT)
Sponsor: Leland Metheny
Not yet recruiting
Building Family Caregiver Skills Using a Simulation-Based Intervention for Care of Cancer Patients
NCT04055948
Condition: Cancer
Interventions: Behavioral: One-on-one teaching sessions; Behavioral: Telephone booster contact
Sponsor: Case Comprehensive Cancer Center
Not yet recruiting
The Effect of the Low Fodmap Diet in Children With Autism Spectrum Disorders
NCT04054349
Condition: Autism Spectrum Disorder
Intervention: Other: Low FODMAP diet
Sponsor: Ohio State University
Completed
Regorafenib in Bevacizumab Refractory Recurrent Glioblastoma
NCT04051606
Condition: Recurrent Glioblastoma
Intervention: Drug: Regorafenib
Sponsor: Case Comprehensive Cancer Center
Not yet recruiting
Effect of a Vibratory Stimulus on Mitigating Nociception-specific Responses to Skin Puncture in Neonates
NCT04050384
Conditions: Infant, Newborn; Infant, Premature; Pain Perception; Pain Measurement; Pain Management; Electroencephalography
Intervention: Device: Baby GentleStick
Sponsor: Lance Relland
Recruiting
Vyxeos for Re-induction Treatment of Acute Myeloid Leukemia Patients With Persistent Disease After Induction
NCT04049539
Conditions: Blasts More Than 5 Percent of Bone Marrow Nucleated Cells; Persistent Disease; Refractory Acute Myeloid Leukemia
Intervention: Drug: Liposome-encapsulated Daunorubicin-Cytarabine
Sponsors: Ohio State University Comprehensive Cancer Center; National Cancer Institute (NCI)
Not yet recruiting
Healthy Eating, Activity and Reduction of Teen Stress
NCT04038684
Conditions: Overweight and Obesity; Overweight Adolescents; Emotional Stress; Stress, Psychological; Eating Behavior
Interventions: Behavioral: Mindfulness-Based Weight Control (MBWC); Behavioral: Standard Behavioral Weight Control (SBWC)
Sponsors: Kent State University; Case Western Reserve University; The Miriam Hospital; Brown University; Rhode Island Hospital; University of North Carolina, Chapel Hill
Recruiting
Triamcinolone With Vitamin D Synergistic Efficacy in Psoriasis
NCT04036188
Conditions: Plaque Psoriasis; Vitamin D3
Interventions: Drug: Triamcinolone; Dietary Supplement: Vitamin D3; Drug: Placebo
Sponsor: Wright State Physicians
Not yet recruiting
Comprehensive Study of Post-surgical Pain After Pectus or Spine Surgery
NCT04031716
Conditions: Pain, Postoperative; Excavatum, Pectus; Scoliosis Idiopathic
Intervention: Behavioral: Meditation
Sponsor: Children's Hospital Medical Center, Cincinnati
Enrolling by invitation
Randomized Trial of LENA Home in A Home Visiting Program
NCT04031326
Conditions: Parent-Child Relations; Language Development
Intervention: Behavioral: LENA Home
Sponsors: Children's Hospital Medical Center, Cincinnati; Every Child Succeeds; The Carol Ann and Ralph V. Haile, Jr./U.S. Bank Foundation; Bethesda, Inc.
Recruiting
Comparing Children's Books to Brochures for Safe Sleep and Infant Reading Education During Prenatal Care
NCT04031235
Conditions: Sudden Unexplained Infant Death; Child Rearing; Literacy
Interventions: Behavioral: Sleep Baby, Safe and Snug; Behavioral: Read Baby, Every Day
Sponsors: Children's Hospital Medical Center, Cincinnati; The DeCavel Family SIDS Foundation
Recruiting
Corneal Oxygen Uptake With Apioc Contact Lenses
NCT04031118
Condition: Contact Lens-Induced Corneal Disorder of Both Eyes (Diagnosis)
Intervention: Device: Apioc Contact Lens
Sponsor: Lentechs, LLC
Enrolling by invitation
Improving Print Knowledge for Children With Hearing Loss: A Pilot Study
NCT04027881
Condition: Hearing Loss, Sensorineural
Intervention: Behavioral: Sit Together and REad
Sponsor: Ohio State University
Not yet recruiting
Targeted Breast Milk Fortification for Very Low Birth Weight Infants in the NICU
NCT04025021
Conditions: Human Milk; Neonate; Breast Milk
Interventions: Dietary Supplement: Targeted Fortification; Device: The Miris Human Milk Analyzer
Sponsor: MetroHealth Medical Center
Enrolling by invitation
Sequential Hypo- and Normo-thermic Perfusion to Preserve Extended Criteria Donor Livers for Transplantation
NCT04023773
Condition: Liver Transplantation
Intervention: Device: Liver Machine Perfusion (MP) device
Sponsor: The Cleveland Clinic
Not yet recruiting
Myeloid-Derived Suppressor Cell Function in Breast Cancer Patients
NCT04022616
Condition: Breast Cancer
Intervention: Other: Specimen collection
Sponsors: Ohio State University Comprehensive Cancer Center; National Cancer Institute (NCI)
Recruiting
The Effects of Oscillating-Rotating Electric Toothbrushes on Plaque and Gingival Health
NCT04017507
Conditions: Gingivitis; Plaque
Interventions: Device: Oscillating-rotating electric toothbrush; Device: Side-to-side electric toothbrush; Device: Manual toothbrush
Sponsor: Procter and Gamble
Completed
Human-Animal Interaction to Promote Recovery Following Pediatric Brain Injury
NCT04016961
Conditions: Brain Injuries; Acquired Brain Injury; Traumatic Brain Injury
Interventions: Other: AAT - Dog; Other: TAU - No Dog
Sponsors: Children's Hospital Medical Center, Cincinnati; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Not yet recruiting
Feasibility of Action Observation and Repetitive Task Practice on Upper Extremity Outcomes in Chronic Stroke Survivors
NCT04015271
Conditions: Stroke; Hemiparesis
Interventions: Behavioral: Action Observation + Repetitive Task Practice; Behavioral: Placebo Video + Repetitive Task Practice
Sponsor: Ohio State University
Recruiting
Study of Pembrolizumab Plus SurVaxM for Glioblastoma at First Recurrence
NCT04013672
Condition: Recurrent Glioblastoma
Interventions: Drug: Pembrolizumab; Drug: SurVaxM; Drug: Sargramostim; Drug: Montanide ISA 51
Sponsor: Manmeet Ahluwalia, MD
Not yet recruiting
Targeted Therapy With CDK4/6 Inhibitors in Chemo-Refractory, Rb Wild-Type Extensive SCLC
NCT04010357
Condition: Small-cell Lung Cancer
Intervention: Drug: Abemaciclib,
Sponsor: Case Comprehensive Cancer Center
Not yet recruiting
Anterior Gastropexy vs. No Anterior Gastropexy for Paraesophageal Hernia Repair
NCT04007952
Conditions: Paraesophageal Hernia; Hiatal Hernia Large
Intervention: Procedure: Anterior Gastropexy
Sponsor: The Cleveland Clinic
Recruiting
Single-Armed Use of ViviGen Cellular Bone Matrix in Patients Undergoing Posterolateral Lumbar Surgery
NCT04007094
Conditions: Degenerative Disc Disease; Spinal Stenosis; Spondylosis; Spondylolisthesis
Intervention: Drug: ViviGen Cellular Bone Matrix
Sponsors: Ohio State University; DePuy Synthes
Recruiting
Meta-analysis of Stannous Fluoride and the Effects on Dental Plaque
NCT04006483
Condition: Dental Plaque
Interventions: Drug: Stannous fluoride dentifrice; Drug: Positive control dentifrice; Drug: Negative control dentifrice
Sponsor: Procter and Gamble
Completed
Meta-analysis of Stannous Fluoride and the Effects on Enamel Erosion
NCT04006470
Condition: Enamel Erosion
Interventions: Drug: Stannous fluoride dentifrice; Drug: Positive control dentifrice; Drug: Negative control dentifrice
Sponsor: Procter and Gamble
Completed
Meta-analysis of Stannous Fluoride Dentifrice and the Effects on Dentine Hypersensitivity
NCT04005417
Condition: Dentine Hypersensitivity
Interventions: Drug: Stannous fluoride dentifrice; Drug: Positive control dentifrice; Drug: Negative control dentifrice
Sponsor: Procter and Gamble
Completed
Tracking Device Guided Feedback to Enhance Patient Physician Interaction
NCT04004806
Conditions: Physician Patient Relation; Burnout, Professional
Intervention: Device: Hill Rom tracking device
Sponsors: The Cleveland Clinic; Accreditation Council for Graduate Medical Education
Enrolling by invitation
Feasibility of Collecting Stress Biomarkers Among Youth Experiencing Homelessness
NCT04004520
Condition: Stress, Physiological
Interventions: Behavioral: Virtual Reality with Meditation; Behavioral: Audio Control; Behavioral: Virtual reality Control
Sponsor: Ohio State University
Not yet recruiting
Laser Cell Therapy for Knee Cartilage Repair
NCT04001361
Condition: Knee Osteoarthritis
Intervention: Procedure: Laser Cell Therapy
Sponsor: Endocellutions
Not yet recruiting
Pilot Study of Powered Exoskeleton Use for Gait Rehabilitation in Individuals With Multiple Sclerosis
NCT04000373
Conditions: Multiple Sclerosis; Gait Disorders, Neurologic
Intervention: Device: Ekso GT™ exoskeleton
Sponsor: The Cleveland Clinic
Not yet recruiting
S-Nitrosylation (SNO) Therapy During Autologous Blood Transfusion
NCT03999229
Condition: Transfusion Related Complication
Interventions: Drug: SNO; Drug: Normal Saline; Drug: Red Blood Cell
Sponsors: James Reynolds; Case Western Reserve University; National Heart, Lung, and Blood Institute (NHLBI)
Recruiting
The Effect of Local Analgesia on Postoperative Gluteal Pain in Patients Undergoing Sacrospinous Ligament Fixation: A Randomized Trial
NCT03995641
Conditions: Postoperative Pain; Pelvic Organ Prolapse; Trigger Point Injection; Sacrospinous Ligament Fixation
Intervention: Drug: marcaine and kenalog
Sponsor: Kettering Health Network
Recruiting
ICE T for Post GYN Surgery Pain
NCT03987022
Condition: Opioid Substitution Treatment
Interventions: Drug: Ketorolac; Drug: Opioids; Other: Ice Packs; Drug: Tylenol; Drug: Motrin; Drug: dilaudid
Sponsor: MetroHealth Medical Center
Recruiting
A Pilot Study to Assess the Accuracy of Blood Pressure Assessment by the Omron HeartGuide Smartwatch
NCT03986281
Conditions: Hypertension; Cardiac Disease; Surgery
Interventions: Other: Omron Wearable Device; Other: Standard Arterial Line
Sponsor: The Cleveland Clinic
Recruiting
A Single Session Pain Psychology Class for Spine Surgery Patients
NCT03985436
Condition: Lumbar; Injury
Intervention: Behavioral: Trek for Surgical Success
Sponsor: Sara Davin, PsyD, MPH
Enrolling by invitation
Daily Living Skills Intervention for 9th and 10th Graders With Autism Spectrum Disorders
NCT03984513
Condition: Autism Spectrum Disorder
Interventions: Behavioral: Surviving and Thriving in the Real World; Behavioral: Program for the Education and Enrichment of Relational Skills
Sponsors: Children's Hospital Medical Center, Cincinnati; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting
A Program to Increase Sickle Cell Trait Knowledge Among Parent of Infants Identified in Newborn Screening
NCT03984500
Condition: Sickle Cell Trait
Intervention: Other: Education
Sponsors: Nationwide Children's Hospital; National Institutes of Health (NIH); National Heart, Lung, and Blood Institute (NHLBI)
Recruiting
Daily Living Skills Intervention for Adolescents With Autism Spectrum Disorder
NCT03984487
Condition: Autism Spectrum Disorder
Interventions: Behavioral: Surviving and Thriving in the Real World; Behavioral: Program for the Education and Enrichment of Relational Skills
Sponsors: Children's Hospital Medical Center, Cincinnati; United States Department of Defense
Recruiting
IPACK Versus Popliteal Sciatic Nerve Block in ACL Reconstruction
NCT03983941
Condition: Anterior Cruciate Ligament Tear
Intervention: Drug: Ropivacaine injection
Sponsor: Sujana Dontukurthy
Not yet recruiting
Efficacy and Application of the Alfred SmartBag System After Ileostomy Creation in Colorectal Surgery: A Pilot Study
NCT03982875
Conditions: Ileostomy - Stoma; Ileostomy; Complications
Intervention: Device: Alfred SmartBag
Sponsors: 11 Heath and Technologies Limited; The Cleveland Clinic
Recruiting
Innovations to Prevent Relapse Among Low-income African American Smokers
NCT03982576
Condition: Smoking Cessation
Interventions: Other: Nicotine replacement therapy (NRT); Behavioral: CS-CBT intervention; Behavioral: Path2Quit; Behavioral: Relapse prevention program; Behavioral: SmokefreeTXT
Sponsor: Case Comprehensive Cancer Center
Not yet recruiting
Dietary Supplementation in Heart Failure
NCT03980574
Condition: Heart Failure
Intervention: Dietary Supplement: R Drink
Sponsors: Ohio State University; Vascular Scientific, LLC
Recruiting
A Pilot Study of KPL-914 in Recurrent Pericarditis
NCT03980522
Condition: Recurrent Pericarditis
Intervention: Drug: KPL-914
Sponsor: Kiniksa Pharmaceuticals, Ltd.
Completed
Trial of Blood Flow Restriction Plus Physical Therapy vs. Physical Therapy Alone for Lateral Epicondylitis
NCT03978897
Condition: Lateral Epicondylitis
Interventions: Device: Blood flow restriction tourniquet; Other: Evidence based physical/occupational therapy
Sponsor: Akron General Medical Center
Not yet recruiting
Dual-benefits of Aerobic and Resistance Training
NCT03978572
Conditions: Sarcopenia; Aging; Disability Physical
Interventions: Behavioral: Resistance Training; Behavioral: Moderate-Intensity Continuous Cycling; Behavioral: High-Intensity Interval Cycling
Sponsors: Ohio University; American Heart Association
Recruiting
Dabrafenib, Trametinib, and IMRT in Treating Patients With BRAF Mutated Anaplastic Thyroid Cancer
NCT03975231
Conditions: BRAF NP_004324.2:p.V600E; BRAF V600K Mutation Present; Thyroid Gland Anaplastic Carcinoma
Interventions: Drug: Dabrafenib; Radiation: Intensity-Modulated Radiation Therapy; Drug: Trametinib
Sponsors: Manisha Shah; National Cancer Institute (NCI)
Not yet recruiting
Gut-level Antiinflammatory Activities of Green Tea in Metabolic Syndrome
NCT03973996
Conditions: Dysbiosis; Endotoxemia; Metabolic Syndrome; Inflammation
Interventions: Dietary Supplement: Green Tea Extract; Dietary Supplement: Placebo
Sponsors: Ohio State University; USDA Beltsville Human Nutrition Research Center
Recruiting
Parastomal Hernia Repair Utilizing the Retromuscular Sugarbaker Versus Keyhole Mesh Techniques
NCT03972553
Condition: Parastomal Hernia
Interventions: Procedure: Sugarbaker technique for repairing parastomal hernia; Procedure: Keyhole technique for repairing parastomal hernia
Sponsor: The Cleveland Clinic
Recruiting
A Problem Solving Intervention for Post-ICU Cognitive Impairment in Older Adults
NCT03972384
Conditions: Critical Illness; Mechanical Ventilation Complication; Delirium; Cognitive Impairment
Intervention: Behavioral: Post-ICU Problem Solving
Sponsor: Ohio State University
Not yet recruiting
Meta-analysis of Stannous Fluoride and the Effects on Gingival Health
NCT03970759
Condition: Gingivitis
Interventions: Drug: Stannous Fluoride Dentifrice; Drug: Positive control dentifrice; Drug: Negative control dentifrice
Sponsor: Procter and Gamble
Completed
Evaluation of Step-Based Care for Individuals at Clinical High Risk for Psychosis
NCT03970005
Condition: Prodromal Schizophrenia
Intervention: Behavioral: Step-Based Care Model
Sponsors: Ohio State University; Substance Abuse and Mental Health Services Administration (SAMHSA)
Enrolling by invitation
Oral Ketorolac for Arthroscopic Rotator Cuff Repair
NCT03967847
Conditions: Rotator Cuff Tear; Postoperative Pain
Intervention: Drug: Ketorolac
Sponsor: University Hospitals Cleveland Medical Center
Recruiting
TRPV2 Agonists in the Fontan Circulation
NCT03965351
Condition: Fontan
Intervention: Drug: Probenecid
Sponsors: Children's Hospital Medical Center, Cincinnati; American Heart Association
Active, not recruiting
Kidney Fibrosis and MRI
NCT03964948
Condition: Kidney Diseases
Intervention: Diagnostic Test: Kidney MRI
Sponsor: Children's Hospital Medical Center, Cincinnati
Recruiting
Effect of One-lung Ventilation on BIS Values
NCT03962036
Conditions: Surgery; Thoracic
Intervention: Device: Bispectral index monitor
Sponsor: Christopher McKee
Not yet recruiting
Cancer Activity and Lifestyle Measurement Study
NCT03961685
Condition: Breast Cancer
Intervention:
Sponsor: Ohio State University
Recruiting
Glycemic Characterization and Pancreatic Imaging Correlates in Cystic Fibrosis
NCT03961516
Conditions: Cystic Fibrosis; Cystic Fibrosis-related Diabetes; Cystic Fibrosis Liver Disease; Pancreatic Steatosis; Hepatic Steatosis
Interventions: Device: Frequently Sampled Oral Glucose Tolerance Test and CGM; Radiation: MRI Pancreas and Liver
Sponsor: University Hospitals Cleveland Medical Center
Recruiting
Gadoxetate Sodium Enhanced MRI as a Biomarker for Aggressive Prostate Cancer
NCT03960788
Conditions: Cancer of the Prostate; Castration-resistant Prostate Cancer
Intervention: Drug: Gadoxetate Sodium
Sponsor: University of Cincinnati
Recruiting
Photodynamic Therapy and Microvesicles
NCT03960125
Conditions: Photodynamic Therapy; Microvesicle Particle
Interventions: Device: Photodynamic Therapy; Drug: 4% Imipramine; Drug: Base Cream
Sponsor: Jeffrey B. Travers, MD, PhD
Not yet recruiting
Behavioral Economics and Adherence in Teens (BEAT!)
NCT03958331
Conditions: Epilepsy; Adherence, Medication
Interventions: Behavioral: Automated Digital Reminders; Behavioral: Individualized Adherence Feedback Report; Behavioral: Individual Adherence Feedback Report with Social Norms
Sponsors: Children's Hospital Medical Center, Cincinnati; National Institute of Nursing Research (NINR); Nationwide Children's Hospital
Not yet recruiting
OT Via Telehealth (ASD and ADHD)
NCT03957993
Conditions: Autism Spectrum Disorder; Attention Deficit Hyperactivity Disorder
Interventions: Other: Occupational Therapy via Telehealth; Other: Standard of Care Occupational Therapy
Sponsor: Children's Hospital Medical Center, Cincinnati
Recruiting
Remote Access: Cortical Visual Impairment
NCT03957980
Condition: Cortical Visual Impairment
Intervention: Other: Occupational therapy
Sponsor: Children's Hospital Medical Center, Cincinnati
Completed
CPX-351 Therapy for MDS After Hypomethylating Agent Failure
NCT03957876
Condition: Myelodysplastic Syndrome (MDS)
Intervention: Drug: CPX-351
Sponsor: Case Comprehensive Cancer Center
Recruiting
Evaluation of the Prenatal Trip Assistance Pilot Project
NCT03956810
Conditions: Pregnancy Preterm; Infant Death
Interventions: Other: On-demand transportation; Other: Usual transportation
Sponsor: Ohio State University
Recruiting
Cardiovascular Outcomes in Bariatric Surgery Patients With Type 2 Diabetes
NCT03955952
Conditions: Obesity; Type2 Diabetes; Bariatric Surgery Candidate
Intervention: Procedure: Bariatric Surgery
Sponsor: The Cleveland Clinic
Enrolling by invitation
AveXis Managed Access Program Cohort for Access to AVXS-101
NCT03955679
Condition: Spinal Muscular Atrophy
Intervention: Genetic: AVXS-101
Sponsors: United BioSource Corporation; AveXis, Inc.
Approved for marketing
Healthy Relationships Training Study: A Comparison of Interventions to Reduce Dating Violence on College Campuses
NCT03950128
Condition: Dating Violence
Interventions: Behavioral: Mindfulness-Based Skills Training (MBST); Behavioral: Psychoeducational
Sponsor: Kent State University
Completed
Free Flap Breast Reconstruction Using Virtual Surgical Planning and 3-D Modeling
NCT03949491
Condition: Breast Reconstruction
Intervention: Procedure: 3D medical models
Sponsor: Case Comprehensive Cancer Center
Not yet recruiting
Ultrasound Assessment of the Inferior Vena Cava in Children
NCT03948282
Condition: Surgery
Intervention:
Sponsor: Alok Moharir
Not yet recruiting
Efficacy of Baricitinib In Treatment of Delayed-Type Hypersensitivity Versus Irritant Skin Reactions in Healthy Adult Male Subjects
NCT03945760
Condition: Allergic Contact Dermatitis
Interventions: Drug: Baricitinib; Drug: Placebo
Sponsor: Wright State Physicians
Not yet recruiting
CT-P13 (Infliximab) Subcutaneous Administration in Patients With Moderately to Severely Active Crohn's Disease
NCT03945019
Condition: Crohn's Disease
Interventions: Biological: CT-P13 SC (Infliximab); Other: Placebo SC
Sponsor: Celltrion
Recruiting
Ibrutinib and Venetoclax in Treating Patients With Chronic Lymphocytic Leukemia After Ibrutinib Resistance
NCT03943342
Conditions: Chronic Lymphocytic Leukemia; Loss of Chromosome 17p
Interventions: Drug: Ibrutinib; Drug: Venetoclax
Sponsors: Kerry Rogers; National Cancer Institute (NCI); Janssen Research & Development, LLC
Not yet recruiting
Proton Accelerated Partial Breast Irradiation
NCT03940248
Condition: Breast Cancer
Intervention: Radiation: Proton Accelerated Partial Breast Irradiation
Sponsor: University of Cincinnati
Enrolling by invitation
Preemptive Infusion of Donor Lymphocytes Depleted of TCR + T Cells + CD19+ B Cells Following ASCT
NCT03939585
Conditions: Allogeneic Stem Cell Transplant Candidate; Acute Myeloid/Lymphoblastic Leukemia; Myelodysplastic Syndrome; Myeloproliferative Neoplasm; Lymphoproliferative Disorders
Intervention: Biological: Cellular therapy product
Sponsor: Case Comprehensive Cancer Center
Not yet recruiting
Randomized Control Trial Comparing Transfascial Suture for Mesh Fixation to No Mesh Fixation
NCT03938688
Conditions: Ventral Hernia; Incisional Hernia
Intervention: Procedure: Mesh placement with Transfascial Sutures
Sponsor: The Cleveland Clinic
Not yet recruiting
The Renin-Angiotensin-Aldosterone System in Adiposity, Blood Pressure and Glucose in African Americans
NCT03938389
Conditions: PreDiabetes; Impaired Glucose Tolerance; Obesity; Blood Pressure
Interventions: Drug: Sacubitril-Valsartan Tab 97-103 MG; Drug: Valsartan 160mg; Drug: Placebo Oral Tablet
Sponsors: Ohio State University; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Not yet recruiting
Motivational Interviewing and Vaccine Hesitancy in Children
NCT03934008
Condition: Vaccine Hesitancy
Intervention: Other: MOtivational interviewing Tool to Improve Vaccine AdherencE (MOTIVE)
Sponsors: Cedarville University; Merck Investigator Studies Program; Rocking Horse Community Health Center
Recruiting
Study Assessing Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MGTA-145 in Healthy Volunteers as a Single Agent or in Combination With Plerixafor
NCT03932864
Condition: Healthy Volunteers
Interventions: Biological: MGTA-145; Biological: plerixafor; Biological: Placebo
Sponsor: Magenta Therapeutics, Inc.
Recruiting
Gene Expression Changes In Young and Geriatric Skin
NCT03932162
Conditions: UVB Phototherapy Burn; Insulin-like Growth Factor 1; Aging
Interventions: Drug: Insulin-Like Growth Factor 1; Other: No Insulin-Lie Growth Factor 1
Sponsor: Jeffrey B. Travers, MD, PhD
Not yet recruiting
Collaborating to Implement Cross-System Interventions in Child Welfare and Substance Use
NCT03931005
Conditions: Substance Use; Implementation; Child Maltreatment; System Fragmentation
Interventions: Other: Collaboration Decision Support Guide; Other: General Collaboration Support
Sponsor: Ohio State University
Not yet recruiting
18F-Fluciclovine PET to Distinguish Tumor Progression From Radiation Necrosis
NCT03930173
Condition: Secondary Malignant Neoplasm of Brain and Cerebral Meninges
Interventions: Drug: 18F-fluciclovine; Device: PET/CT of the brain
Sponsor: Case Comprehensive Cancer Center
Recruiting
Liposomal Bupivacaine Versus Interscalene Nerve Block
NCT03929146
Condition: Pain, Postoperative
Interventions: Drug: Exparel; Procedure: Interscalene Nerve Block
Sponsor: University of Cincinnati
Recruiting
Feasibility of a Culturally-Specific Video Text Cessation Intervention With AA Quitline Callers
NCT03927976
Condition: Tobacco Use Cessation
Intervention: Behavioral: Path2Quit - culturally specific text message intervention
Sponsor: Case Comprehensive Cancer Center
Not yet recruiting
GSNOR Phenotyping/GSNO Challenge
NCT03926741
Conditions: Asthma; Healthy Volunteers
Intervention: Drug: GSNO
Sponsors: James Reynolds; University Hospitals Cleveland Medical Center; Case Western Reserve University; National Heart, Lung, and Blood Institute (NHLBI)
Recruiting
Screening for Systemic Amyloidosis Via the Ligamentum Flavum
NCT03923920
Conditions: Amyloid; Amyloidosis; Spinal Stenosis; Transthyretin Amyloidosis; Primary Amyloidosis of Light Chain Type
Intervention: Procedure: Biopsy
Sponsor: The Cleveland Clinic
Recruiting
Pelvic Floor Muscle Training With Leva System for Urge Incontinence
NCT03923348
Conditions: Overactive Bladder; Urge Urinary Incontinence; Mixed Urinary Incontinence
Intervention: Device: Leva device
Sponsors: The Christ Hospital; Renovia, Inc.
Recruiting
Study of the Safety and Efficacy of DPI-386 Nasal Gel on Ocean-Going Vessels
NCT03920644
Conditions: Prevention of Nausea Associated With Motion Sickness; Treatment of Nausea Associated With Motion Sickness
Interventions: Drug: Scopolamine Transdermal Patch [Transderm Scop]; Drug: Scopolamine; Drug: Placebo Patch; Drug: Placebo Gel
Sponsor: Naval Aeromedical Research Unit, Dayton
Recruiting
A Clinical Study of the Eztetic Dental Implant System
NCT03917927
Condition: Edentulous Jaw
Intervention: Device: Eztetic dental implant
Sponsor: Zimmer Biomet
Recruiting
Older Adult Effectiveness of 2 Treatments
NCT03916926
Condition: Dental Caries
Interventions: Device: A "simple medical strategy" consisting of silver diamine fluoride (SDF); Device: B "typical dental strategy" consisting of atraumatic restorative treatment (ART) with glass ionomer cement + Fluoride varnish (FV)
Sponsors: Case Western Reserve University; Patient-Centered Outcomes Research Institute
Not yet recruiting
Registry and Screening Tool to Identify Children With Asthma Likely to Benefit From Home Assessment and Remediation
NCT03916237
Conditions: Asthma; Pediatric ALL; School Health Services; Registries; Medical Informatics; Home Visits; Housing Problems; Social Determinants of Health; Healthcare Disparity; Health Status Disparity
Interventions: Other: Home assessment; Other: Home remediation; Other: Referral to Medical Legal Partnership; Other: Asthma SDH screening tool
Sponsors: MetroHealth Medical Center; Cleveland Metropolitan School District; Environmental Health Watch; Legal Aid Society of Cleveland
Not yet recruiting
Fuzzy AI Using VR for Collision Prevention
NCT03915119
Condition: Injuries
Intervention: Other: GFT AI training
Sponsor: Children's Hospital Medical Center, Cincinnati
Active, not recruiting
Testing the Combination of Cabozantinib, Nivolumab, and Ipilimumab (CaboNivoIpi) for Advanced Differentiated Thyroid Cancer
NCT03914300
Conditions: Differentiated Thyroid Gland Carcinoma; Follicular Variant Thyroid Gland Papillary Carcinoma; Poorly Differentiated Thyroid Gland Carcinoma; Progressive Thyroid Carcinoma; Refractory Thyroid Gland Carcinoma; Tall Cell Variant Thyroid Gland Papillary Carcinoma; Thyroid Gland Follicular Carcinoma; Thyroid Gland Hurthle Cell Carcinoma; Thyroid Gland Papillary Carcinoma
Interventions: Drug: Cabozantinib; Drug: Cabozantinib S-malate; Biological: Ipilimumab; Biological: Nivolumab
Sponsor: National Cancer Institute (NCI)
Recruiting
Fontan Associated Liver Disease
NCT03914196
Condition: Fontans
Intervention: Diagnostic Test: Liver Stiffness Ultrasound
Sponsor: Children's Hospital Medical Center, Cincinnati
Recruiting
Effects of Neuromuscular Training on EEG Adaptations in Young Athletes
NCT03913975
Condition: Brain Concussion
Intervention: Other: Neuromuscular training
Sponsor: Children's Hospital Medical Center, Cincinnati
Completed
Hemoglobin Desaturation in Sickle Cell Disease
NCT03908385
Condition: Sickle Cell Disease
Intervention:
Sponsor: University Hospitals Cleveland Medical Center
Recruiting
Liposomal Bupivacaine After Cesarean Delivery
NCT03907813
Conditions: Pain, Postoperative; Opioid Use
Interventions: Drug: Exparel; Other: Saline infiltration
Sponsor: Wright State University
Not yet recruiting
Advance Care Planning GuideTailored for Primary Care Patients
NCT03906773
Conditions: Advance Care Planning; Chronic Disease; Communication Research
Intervention: Other: Patient Centered Medical Home Based Electronic Framework for Advance Care Planning
Sponsor: Ohio State University
Completed
Effectiveness of Fractionated Laser Resurfacing to Protect Geriatric Skin From Actinic Neoplasia
NCT03906253
Conditions: Actinic Keratoses; Aging; Non-Melanoma Skin Cancer
Intervention: Device: Fractionated Laser Resurfacing
Sponsor: Jeffrey B. Travers, MD, PhD
Recruiting
Identification of microRNAs Involved in Cerebral Collateral Regulation
NCT03905434
Condition: Cerebrovascular Disorders
Intervention: Genetic: miRNA sampling
Sponsor: Ohio State University
Recruiting
Defining the Operating Characteristics of NIRS in the Diagnosis of Pediatric Traumatic Intracranial Hemorrhage
NCT03905031
Conditions: Craniocerebral Injuries; Head Injuries; Head Injury, Minor; Head Trauma; Traumatic Brain Injury; Traumatic Brain Hemorrhage; Hematoma of Head; Intracranial Hemorrhages
Intervention: Device: InfraScanner 2000
Sponsor: Dayton Children's Hospital
Recruiting
Testing the Safety and Tolerability of CX-4945 in Patients With Recurrent Medulloblastoma Who May or May Not Have Surgery
NCT03904862
Condition: Medulloblastoma, Childhood
Intervention: Drug: CX 4945
Sponsors: Pediatric Brain Tumor Consortium; St. Jude Children's Research Hospital; National Cancer Institute (NCI)
Recruiting
Post-partum Non-pharmacologic Pain Management
NCT03903172
Conditions: Pain Management; Vaginal Delivery
Intervention: Device: Abdominal binder
Sponsor: Wright State University
Enrolling by invitation
Optical Treatment of Migraines Using the Avulux™ Optical Filter in the Form of Spectacle Lenses.
NCT03902496
Condition: Migraine
Interventions: Other: HIT-6 Questionnaire; Device: Avulux Spectacles; Device: Sham Spectacles
Sponsor: Avulux, Inc.
Completed
A Protein-sparing Modified Fast for Children and Adolescents With Severe Obesity (PSMF)
NCT03899311
Condition: Obesity, Childhood
Intervention: Other: protein-sparing modified fast diet
Sponsor: Ihuoma Eneli
Completed
An Early Feasibility Study of the ReHAB System
NCT03898804
Condition: Tetraplegia
Intervention: Device: BCI and FES
Sponsor: Jonathan Miller, MD
Not yet recruiting
The Effect of Psychologically Informed Education in Adolescents With Anterior Knee Pain
NCT03897907
Conditions: Patellofemoral Pain Syndrome; Anterior Knee Pain Syndrome
Interventions: Other: Psychologically Informed Education Video; Other: Anatomy Education Video
Sponsor: Nationwide Children's Hospital
Recruiting
Safety & Immunogenicity Study of Ad5 Based Oral Norovirus Vaccines
NCT03897309
Condition: Norovirus Infection
Interventions: Biological: VXA-G1.1-NN; Biological: VXA-G2.4-NS; Biological: Placebo Tablets
Sponsor: Vaxart
Recruiting
Efficacy and Safety of Tildrakizumab in the Treatment of Scalp Psoriasi
NCT03897088
Condition: Scalp Psoriasis
Interventions: Drug: Tildrakizumab; Drug: Placebo
Sponsor: Sun Pharma Global FZE
Recruiting
Teaching Parents Reiki for Their Adolescents Receiving Palliative Care
NCT03896165
Conditions: Palliative Care; Chronic Disease
Intervention: Other: Reiki
Sponsors: Ohio State University; Akron Children's Hospital
Not yet recruiting
Supermarket and Web-Based Intervention Targeting Nutrition (SuperWIN) for Cardiovascular Risk Reduction
NCT03895580
Conditions: Obesity; Hypertension; Hyperlipidemias; Diet Modification
Interventions: Other: In-store POP education; Other: Online POP education
Sponsors: University of Cincinnati; The Kroger Company; Children's Hospital Medical Center, Cincinnati
Recruiting
Use of Lumbar Motion Monitor to Predict Response to Radiofrequency Ablation After Medial Branch Diagnostic Blocks
NCT03894319
Condition: Back Pain
Intervention:
Sponsor: Ohio State University
Recruiting
Database Of Clinical Data For Individuals With Variants In The IRF2BPL Gene
NCT03892798
Conditions: Neurodevelopmental Regression, Seizures, Autism and Developmental Delay (NEDAMSS); Autism Spectrum Disorder; Movement Disorders; Seizures; Dystonia
Intervention: Other: No interventions are planned
Sponsor: Children's Hospital Medical Center, Cincinnati
Recruiting
Duvelisib and Nivolumab in Treating Patients With Richter Syndrome or Transformed Follicular Lymphoma
NCT03892044
Conditions: Chronic Lymphocytic Leukemia; Recurrent Diffuse Large B-Cell Lymphoma; Refractory Diffuse Large B-Cell Lymphoma; Richter Syndrome; Small Lymphocytic Lymphoma; Transformed Chronic Lymphocytic Leukemia to Diffuse Large B-Cell Lymphoma; Transformed Follicular Lymphoma to Diffuse Large B-Cell Lymphoma; Transformed Small Lymphocytic Lymphoma to Diffuse Large B-Cell Lymphoma
Interventions: Drug: Duvelisib; Biological: Nivolumab
Sponsors: Jennifer Woyach; National Cancer Institute (NCI)
Not yet recruiting
Intestinal Microbiome Composition in Infants With Biliary Atresia (BA)
NCT03890536
Conditions: Biliary Atresia; Intrahepatic Cholestases; Normal Controls
Intervention:
Sponsors: Children's Hospital Medical Center, Cincinnati; Wuhan Union Hospital, China
Not yet recruiting
Phase IB Metformin, Digoxin, Simvastatin in Solid Tumors
NCT03889795
Conditions: Advanced Pancreatic Cancer; Advanced Solid Tumor
Interventions: Drug: Metformin; Drug: Simvastatin; Drug: Digoxin
Sponsor: John Nemunaitis, MD
Recruiting
Study of Ketorolac Versus Opioid for Pain After Endoscopy
NCT03888144
Conditions: Kidney Calculi; Ureteral Calculi
Interventions: Drug: Oxycodone; Drug: Ketorolac
Sponsor: The Cleveland Clinic
Recruiting
A Systematic Oral Care Program in Post-Mechanically Ventilated, Post-Intensive Care Patients
NCT03886623
Conditions: Methicillin-resistant Staphylococcus Aureus; Methicillin-Sensitive Staphylococcus Aureus Infection
Interventions: Procedure: 4-day systematic oral hygiene; Other: Standard of Care oral care
Sponsor: Ohio State University
Completed
Cardiac Amyloidosis Screening at Trigger Finger Release
NCT03886155
Conditions: Amyloidosis; Trigger Finger; Transthyretin Amyloidosis; Primary Amyloidosis of Light Chain Type
Intervention: Procedure: Biopsy
Sponsor: The Cleveland Clinic
Recruiting
Safety and Performance of JOURNEYTM II Cruciate Retaining (CR) Total Knee System (TKS)
NCT03885531
Condition: Journey II CR Total Knee System
Intervention: Device: Total knee arthroplasty with Journey II CR Total Knee System
Sponsors: Smith & Nephew, Inc.; Nor Consult
Recruiting
Efficacy of the Dabir Surfaces Micropressure Overlay for Decubitus Ulcer Prevention During Cardiac Surgery
NCT03884634
Conditions: Pressure Ulcer; Pressure Injury
Intervention: Device: Dabir Micropressure Overlay
Sponsor: The Cleveland Clinic
Recruiting
Cysteamine for Asthma
NCT03883984
Condition: Asthma
Interventions: Drug: Cysteamine Bitartrate; Drug: Placebo Oral Tablet
Sponsor: Children's Hospital Medical Center, Cincinnati
Recruiting
Donor-Derived Viral Specific T-cells (VSTs) for Prophylaxis Against Viral Infections After Allogeneic Stem Cell Transplant
NCT03883906
Conditions: Allogeneic Stem Cell Transplant; Viral Infection
Intervention: Biological: Viral Specific T-cells (VSTs)
Sponsors: Children's Hospital Medical Center, Cincinnati; Hoxworth Blood Center
Recruiting
Technology-Assisted Stepped Care Study
NCT03883594
Condition: Asthma
Intervention: Behavioral: Technology-assisted Stepped-care
Sponsor: Children's Hospital Medical Center, Cincinnati
Recruiting
Evaluation of Helmet Technology and Head Impact Exposure
NCT03883451
Conditions: MTBI - Mild Traumatic Brain Injury; Concussion, Mild
Intervention: Other: Helmet Model
Sponsor: Children's Hospital Medical Center, Cincinnati
Active, not recruiting
PoNS Clinical Experience Program (TBI)
NCT03882554
Condition: Mild to Moderate Traumatic Brain Injury
Intervention: Device: PoNS Treatment
Sponsors: Neurohabilitation Corporation; Ohio State University
Recruiting
Clinical Trial of Acupuncture for Chemotherapy-Induced Peripheral Neuropathy
NCT03881748
Condition: Peripheral Neuropathy
Interventions: Other: Manual acupuncture; Other: Electro-acupuncture
Sponsor: Case Comprehensive Cancer Center
Not yet recruiting
Nitrous Oxide for the Treatment of Complex Regional Pain Syndrome
NCT03879538
Condition: Complex Regional Pain Syndrome
Interventions: Drug: Nitrous Oxide; Drug: Oxygen
Sponsor: The Cleveland Clinic
Enrolling by invitation
rVWF Pediatric and Adult Study
NCT03879135
Condition: Von Willebrand Disease
Interventions: Biological: rVWF; Biological: rFVIII
Sponsors: Baxalta now part of Shire; Baxalta Innovations GmbH, now part of Shire
Recruiting
Transcranial Direct Current Stimulation Therapy for Sleepiness Related to Shift Work Disorder (tDCS-SWORD)
NCT03879044
Condition: Shift-Work Sleep Disorder
Intervention: Device: Transcranial Direct Current Stimulation
Sponsor: Ohio State University
Recruiting
Comparing Specimen Collection Techniques to Screen for Sexually Transmitted Infections in Pregnant Women: A Pilot Study
NCT03877263
Condition: Sexually Transmitted Diseases
Interventions: Diagnostic Test: Endocervical swab for detection of STI; Diagnostic Test: Vaginal swab for detection of STI
Sponsor: OhioHealth
Recruiting
rTMS Plus CCFES-mediated Functional Task Practice for Severe Stroke
NCT03870672
Conditions: Stroke; Hemiplegia; Cerebrovascular Accident (CVA); Hemiparesis
Interventions: Device: Contralaterally Controlled Functional Electrical Stimulation; Device: New rTMS approach; Device: Conventional rTMS approach; Device: Sham rTMS approach
Sponsors: The Cleveland Clinic; National Institutes of Health (NIH)
Recruiting
Potential Benefit for Non Invasive Vagus Nerve Stimulation Using GammaCore in the Treatment of Raynaud's Phenomena.
NCT03869008
Conditions: Raynaud Phenomenon; Primary Raynaud Phenomenon; Raynaud Disease; Raynaud Syndrome
Interventions: Device: gammaCore Sapphire; Device: Sham Device
Sponsors: University of Toledo Health Science Campus; ElectroCore INC
Recruiting
Brigatinib in Treating Patients With ALK and ROS1 Gene Alterations and Locally Advanced or Metastatic Solid Cancers
NCT03868423
Conditions: Advanced Malignant Neoplasm; ALK Fusion Protein Expression; ALK Gene Amplification; ALK Gene Mutation; Locally Advanced Malignant Solid Neoplasm; Metastatic Malignant Neoplasm in the Brain; Metastatic Malignant Neoplasm in the Central Nervous System; Metastatic Malignant Solid Neoplasm; ROS1 Fusion Positive; ROS1 Gene Amplification; ROS1 Gene Mutation
Interventions: Drug: Brigatinib; Other: Laboratory Biomarker Analysis; Other: Quality-of-Life Assessment; Other: Questionnaire Administration
Sponsors: Sameek Roychowdhury; National Cancer Institute (NCI)
Not yet recruiting
A Novel Approach for Brain Stimulation in Severe Stroke
NCT03868410
Condition: Stroke
Interventions: Device: New rTMS Approach; Device: Conventional rTMS Approach
Sponsors: The Cleveland Clinic; American Heart Association
Recruiting
Examining Developmental Outcomes of Children Diagnosed With CLN2 Disease
NCT03862274
Conditions: Batten Disease; CLN2; Neuronal Ceroid-Lipofuscinoses
Intervention: Other: CLN2 Treatment
Sponsors: Jessica Scherr; BioMarin Pharmaceutical
Recruiting
Alleviation Of Metabolic Endotoxemia In Adults With Metabolic Syndrome With Milk Fat Globule Membrane
NCT03860584
Conditions: Metabolic Syndrome; Metabolic Endotoxemia
Interventions: Dietary Supplement: MFGM-enriched full-fat dairy milk; Dietary Supplement: Soy phospholipid/lecithin milk
Sponsor: Ohio State University
Recruiting
Precision of OCT and OCTA-based Ocular Measurements
NCT03859310
Condition: Normal Eyes and Ocular Pathology
Intervention: Device: SD-OCT
Sponsor: Optovue
Enrolling by invitation
Inhaled Essential Oil Effect on Common QOL Concerns During Cancer Treatment
NCT03858855
Conditions: Gastrointestinal Cancer; Neuroendocrine Carcinoma; Melanoma
Interventions: Procedure: Aromatherapy and Essential Oils; Other: Subject Diary
Sponsors: Ohio State University Comprehensive Cancer Center; National Cancer Institute (NCI)
Enrolling by invitation
CCFES + tDCS for Motor Control
NCT03857529
Conditions: Active tDCS Concurrent With CCFES; Active tDCS Preceding CCFES; Sham tDCS With CCFES
Intervention: Device: transcranial direct current stimulation and electrical stimulator
Sponsor: MetroHealth Medical Center
Recruiting
Vaginal Prep Solutions to Reduce Bacteria Colony Counts in Patients Having a Vaginal Surgery
NCT03854370
Conditions: Surgical Site Infection; Vaginal Surgery
Interventions: Other: Baby shampoo; Other: Betadine; Other: Peridex; Other: TechniCare
Sponsor: Wright State University
Not yet recruiting
Subcutaneous Methylnaltrexone Versus Placebo for Postoperative Ileus Prevention
NCT03852524
Condition: Postoperative Ileus
Interventions: Drug: Methylnaltrexone; Other: Placebo
Sponsor: Ohio State University
Recruiting
Effects of INDUS810 on Body Composition, Muscular Performance, and Training Adaptations
NCT03850106
Condition: Weakness, Muscle
Interventions: Dietary Supplement: Placebo; Dietary Supplement: Indus810
Sponsors: The Center for Applied Health Sciences, LLC; Indus Biotech
Active, not recruiting
Phase I/II Trial of CPX-351 + Palbociclib in Patients With Acute Myeloid Leukemia
NCT03844997
Conditions: Acute Myeloid Leukemia; AML
Interventions: Drug: Palcociclib; Drug: CPX-351
Sponsor: Aziz Nazha
Recruiting
Postpartum Family Planning
NCT03844633
Condition: Delay in Time to Lactogenesis Stage II
Interventions: Drug: Depo-Provera Injectable Product; Drug: Placebos
Sponsors: Ohio State University; Nationwide Children's Hospital
Recruiting
A Randomized Phase 1 Dose-Escalation Study of Subcutaneously(SC) Administered RUC-4
NCT03844191
Condition: Coronary Disease
Intervention: Drug: RUC-4 Compound
Sponsors: CeleCor Therapeutics; Precision For Medicine; CirQuest Labs; CRL
Recruiting
Hypofractionated Radiotherapy for Recurrent DIPG
NCT03841435
Condition: Recurrent Diffuse Intrinsic Pontine Glioma
Intervention: Radiation: Hypofractionated Radiotherapy
Sponsors: University of Cincinnati; Children's Hospital Medical Center, Cincinnati
Enrolling by invitation
Continuous Bladder Irrigation Following Transurethral Resection of Bladder Tumors
NCT03839472
Conditions: Non-muscle Invasive Bladder Cancer (NMIBC); Bladder Tumor (TURBT)
Intervention: Procedure: CBI
Sponsor: Case Comprehensive Cancer Center
Not yet recruiting
Markers of Trajectory in Pediatric CRPS
NCT03838107
Condition: Complex Regional Pain Syndromes
Intervention: Behavioral: observation and measure of trajectory of recovery in CRPS
Sponsors: Children's Hospital Medical Center, Cincinnati; Chapman Family Donation
Recruiting
SAMPAP Trial -Impact of a Novel Sleep Apnea Management Group Intervention on Positive Airway Pressure Adherence
NCT03835702
Condition: Sleep Apnea
Intervention: Other: SAM Clinic Intervention
Sponsors: The Cleveland Clinic; ResMed
Recruiting
Urinary Retention After Laparoscopic Inguinal Hernia Repair: Comparing the Use of the Intraoperative Urinary Catheter
NCT03835351
Condition: Inguinal Hernia
Intervention: Device: Urinary Catheter
Sponsor: The Cleveland Clinic
Recruiting
Addressing Fear and Risk of Vasovagal Reactions Among High School Donors
NCT03835299
Condition: Blood Donors
Intervention: Behavioral: Fear Intervention
Sponsors: Ohio University; New York Blood Center
Enrolling by invitation
Glutaminase Inhibitor CB-839 Hydrochloride and Osimertinib in Treating Patients With EGFR-Mutated Stage IV Non-small Cell Lung Cancer
NCT03831932
Conditions: Advanced Lung Carcinoma; EGFR Activating Mutation; EGFR Exon 19 Deletion Mutation; EGFR NP_005219.2:p.L858R; EGFR T790M Mutation Negative; Lung Non-Small Cell Carcinoma; Metastatic Lung Carcinoma; Stage IV Lung Cancer AJCC v8; Stage IVA Lung Cancer AJCC v8; Stage IVB Lung Cancer AJCC v8
Interventions: Drug: Glutaminase Inhibitor CB-839; Drug: Glutaminase Inhibitor CB-839 Hydrochloride; Drug: Osimertinib
Sponsor: National Cancer Institute (NCI)
Recruiting
Lamotrigine in Reducing Psychologic Side-Effect of Perioperative Ketamine
NCT03831854
Condition: Reducing Psychological Side Effects of Ketamine
Interventions: Drug: Lamotrigine 300 MG; Drug: Placebo; Drug: Ketamine
Sponsor: The Cleveland Clinic
Recruiting
Attentional Biases, Reward Sensitivity, and Cognitive Control in Adults With Bipolar Disorder
NCT03829787
Condition: Bipolar Disorder
Intervention: Device: Eye tracking
Sponsor: University Hospitals Cleveland Medical Center
Recruiting
Improving Sexual Health in Gynecologic Cancer Patients
NCT03827993
Condition: Gynecologic Cancer
Intervention: Behavioral: dedicated sexual health clinic appointment
Sponsor: Case Comprehensive Cancer Center
Not yet recruiting
Early Feasibility Study of the SENSE Device
NCT03827720
Conditions: Hemorrhagic Stroke; Ischemic Stroke
Intervention: Device: SENSE Device
Sponsor: Sense Diagnostics, LLC
Not yet recruiting
Peer Mentoring to Improve Self-management in Youth With IBD
NCT03827109
Conditions: Pediatric Crohns Disease; Pediatric Ulcerative Colitis; Inflammatory Bowel Diseases
Interventions: Behavioral: Group educational activities; Behavioral: IBD educational website; Behavioral: Monthly check-in calls from program coordinator; Behavioral: Mentor; Behavioral: Fun group activities; Behavioral: Parent support group
Sponsors: Laura Mackner; Children's Hospital Medical Center, Cincinnati; Rosalind Franklin University of Medicine and Science; Children's Hospital and Health System Foundation, Wisconsin
Recruiting
Venetoclax Combined With Vyxeos (CPX-351) for Participants With Relapsed or Refractory Acute Leukemia
NCT03826992
Condition: Leukemia
Interventions: Drug: Vyxeos; Drug: Venetoclax
Sponsor: Children's Hospital Medical Center, Cincinnati
Recruiting
Papaverine Hydrochloride and Stereotactic Body Radiation Therapy in Treating Patients With Non-small Cell Lung Cancer
NCT03824327
Condition: Lung Non-Small Cell Carcinoma
Interventions: Procedure: Blood Oxygen Level Dependent Imaging; Drug: Papaverine Hydrochloride; Radiation: Stereotactic Body Radiation Therapy
Sponsors: Ohio State University Comprehensive Cancer Center; National Cancer Institute (NCI)
Recruiting
Inadvertent Hyperventilation During Intraoperative Care in Neonates
NCT03823716
Condition: Neonatal Disorder
Intervention:
Sponsor: Nationwide Children's Hospital
Enrolling by invitation
Virtual Prostate Biopsy Protocol for Patients on Active Surveillance and at Risk of Prostate Cancer
NCT03823001
Condition: Prostate Cancer
Intervention: Diagnostic Test: virtual biopsy (VB) monitoring protocol
Sponsor: Case Comprehensive Cancer Center
Not yet recruiting
FibroScan ® Study: Assessing Liver Fibrosis in Patients Using Methotrexate for Psoriasis
NCT03820934
Condition: Psoriasis
Intervention: Diagnostic Test: Fibroscan and Fibrosure
Sponsor: University Hospitals Cleveland Medical Center
Withdrawn
Cost-effectiveness of Forced Aerobic Exercise for Stroke Rehabilitation
NCT03819764
Conditions: Stroke; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases
Interventions: Behavioral: Aerobic Exercise; Behavioral: Upper Extremity Repetitive Task Practice
Sponsor: The Cleveland Clinic
Recruiting
Microbiome and Mycobiome Registry of Volunteers With and Without Autism Spectrum Disorder
NCT03819439
Condition: Autism Spectrum Disorder
Intervention: Other: Microbiome and Autism Questionnaire
Sponsor: University Hospitals Cleveland Medical Center
Completed
Proton Based Cardiac Sparing Accelerated Fractionated RadioTherapy in Unresectable NSCLC
NCT03818776
Condition: Non-Small Cell Lung Cancer
Interventions: Drug: Durvalumab; Radiation: Proton beam therapy RT
Sponsor: Case Comprehensive Cancer Center
Not yet recruiting
Urinary Track Infection Prevention After Urogynecological Surgery
NCT03818321
Conditions: Urinary Tract Infections; Urinary Retention Postoperative; Pelvic Organ Prolapse
Interventions: Drug: Methenamine Hippurate 1 g tablet; Drug: Placebo tablet
Sponsor: TriHealth Inc.
Recruiting
Incomplete Follow Up After Positive FIT or Stool DNA Testing: A Multimethod Approach
NCT03817905
Condition: Positive FIT or Stool DNA Testing Follow up
Intervention: Other: Patient navigator
Sponsor: Case Comprehensive Cancer Center
Not yet recruiting
A Novel Wound Retractor Combining Continuous Irrigation and Barrier Protection Reduces Incisional Contamination and Surgical Site Infection in Colorectal Surgery
NCT03816995
Condition: Colorectal Surgery
Interventions: Device: CleanCision Wound Retraction and Protection System; Device: Alexis O Wound Protector
Sponsor: The Cleveland Clinic
Recruiting
A SAD/MAD to Assess the Safety, Pharmacokinetics and Pharmacodynamics of FT-4202 in Healthy Volunteers and Sickle Cell Disease Patients
NCT03815695
Conditions: Healthy Volunteers; Sickle Cell Disease
Interventions: Drug: FT-4202/Placebo; Drug: FT-4202
Sponsors: Forma Therapeutics, Inc.; Medpace, Inc.
Recruiting
Evaluation of Hospital Readmission Rate Dependent on Post-Operative Follow-Up Procedure
NCT03813537
Condition: Postoperative Complications
Intervention: Other: Phone Call
Sponsor: Syed Husain
Recruiting
Spontaneous Void Requirements for Patients Undergoing Ambulatory Anorectal Surgery
NCT03812536
Condition: Complications, Postoperative
Intervention: Other: No Void
Sponsor: Syed Husain
Recruiting
Comparison Air Versus Carbon Dioxide Insufflation in Single Balloon Anterograde Enteroscopy
NCT03811522
Conditions: Carbon Dioxide Insufflation; Anterograde Single Balloon Enteroscopy
Interventions: Other: carbon dioxide insufflation; Other: Air insufflation
Sponsors: North Eastern Ohio Gastroenterology and Endoscopy center; Mercy Health Ohio
Active, not recruiting
Female Patient Preferences Regarding Physician Gender
NCT03811340
Condition: Female Patient Preference
Intervention:
Sponsor: TriHealth Inc.
Active, not recruiting
Effects of a Metronome on Functional Outcomes in Aquatic Therapy
NCT03801772
Condition: Exercise Therapy
Intervention: Device: Metronome
Sponsor: Aultman Health Foundation
Recruiting
Utilization of Hepatitis C Positive Kidneys in Negative Recipients
NCT03801707
Conditions: Kidney Transplant; Hepatitis C; HCV
Intervention: Drug: Sofosbuvir/Velpatasvir
Sponsor: Ohio State University
Recruiting
Predicting the Development of Myocardial Depression in Acute Neurological Patients
NCT03801694
Conditions: Myocardial Depression; Takotsubo Syndrome; Subarachnoid Hemorrhage; Acute Ischemic Stroke
Intervention:
Sponsor: Ohio State University
Recruiting
Threshold Response of Lumbar Selective Nerve Root Block in Predicting Good Outcome Following Lumbar Foraminotomy
NCT03801356
Conditions: Back Pain; Radiculopathy Lumbar; Degenerative Lumbar Spinal Stenosis
Intervention: Diagnostic Test: Selective Nerve Root Block
Sponsors: The Cleveland Clinic; Lumbar Spine Research Society
Recruiting
Stimulation Parameters and Non-motor Symptoms in PD Treated With DBS
NCT03800108
Condition: Parkinson Disease
Intervention: Procedure: Personalized DBS adjustments
Sponsor: Darlene Floden
Recruiting
Real World Effectiveness of Combining an Employer-based Weight Management Program With Medication for Chronic Weight Management in Employees With Obesity
NCT03799198
Condition: Obesity
Interventions: Other: Weight Management Program (WMP); Drug: Medication for chronic weight management (Rx)
Sponsor: Novo Nordisk A/S
Active, not recruiting
Nivolumab and Radiation Therapy or Ipilimumab as Adjuvant Therapy in Treating Patients With Merkel Cell Cancer
NCT03798639
Conditions: Merkel Cell Carcinoma; Pathologic Stage IIIA Merkel Cell Carcinoma AJCC v8; Pathologic Stage IIIB Merkel Cell Carcinoma AJCC v8
Interventions: Biological: Ipilimumab; Biological: Nivolumab; Radiation: Radiation Therapy
Sponsors: Hiral Shah; National Cancer Institute (NCI)
Recruiting
Accuracy of the Apple Watch Series 4 for Detection of Heart Rhythm: A Pilot Study
NCT03798613
Conditions: Heart Rate Fast; Heart Rate Low
Interventions: Device: Apple Watch 4 Series Device; Device: Continuous Telemetry Monitor
Sponsors: The Cleveland Clinic; Case Western Reserve University
Completed
CI Following VS Removal or Labyrinthectomy
NCT03795675
Conditions: Vestibular Schwannoma; Meniere Disease
Intervention: Device: Cochlear Implant
Sponsors: Ohio State University; Advanced Bionics
Recruiting
Comparison of Dorsal Column Stimulation to Dorsal Root Ganglion Stimulation for Complex Regional Pain Syndrome
NCT03794024
Condition: Complex Regional Pain Syndrome
Interventions: Device: The Nuvectra Algovita Dorsal Column Spinal Cord Stimulator; Device: The Axium Neurostimulator System
Sponsor: The Cleveland Clinic
Recruiting
Impact of OSA on Outcomes in Acute Coronary Syndrome
NCT03793582
Conditions: OSA; ACS - Acute Coronary Syndrome; Major Adverse Cardiac Events
Intervention: Diagnostic Test: ApneaLink Type III portable sleep study
Sponsor: MetroHealth Medical Center
Recruiting
Evaluating The Efficacy Of A Mind-Body Intervention In Overcoming Opioid Addiction
NCT03791645
Conditions: Opioid Use; Opioid-use Disorder; Substance Use Disorders
Intervention: Behavioral: Sky Intervention
Sponsor: Ohio State University
Recruiting
Study of Euthyroid Hypothyroxinemia in Metastatic Breast Carcinoma
NCT03787303
Conditions: Metastatic Breast Cancer; Thyroid Dysfunction
Intervention: Drug: Triiodothyronine (T3)
Sponsor: Aultman Health Foundation
Recruiting
A Placebo-Controlled, Two-Part Study, Oral Dose to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of CNTX-6970 in Healthy Subjects
NCT03787004
Conditions: Chronic Pain; Nociceptive Pain
Interventions: Drug: CNTX-6970; Other: Placebo
Sponsor: Centrexion Therapeutics
Completed
Stress, Sex, and Fear
NCT03786952
Condition: Psychological Stress
Interventions: Behavioral: Stress immediately before learning in males; Behavioral: Sham control immediately before learning in males; Behavioral: Stress 30 minutes before learning in males; Behavioral: Sham control 30 minutes before learning in males; Behavioral: Stress immediately before learning in females; Behavioral: Sham control immediately before learning in females; Behavioral: Stress 30 minutes before learning in females; Behavioral: Sham control 30 minutes before learning in females
Sponsors: Ohio Northern University; National Institute of Mental Health (NIMH)
Recruiting
Intensity Modulated Radiation Therapy or 3-Dimensional Conformal Radiation Therapy in Treating Patients With Lymph-Node Positive Breast Cancer
NCT03786354
Conditions: Anatomic Stage II Breast Cancer AJCC v8; Anatomic Stage IIA Breast Cancer AJCC v8; Anatomic Stage IIB Breast Cancer AJCC v8; Anatomic Stage III Breast Cancer AJCC v8; Anatomic Stage IIIA Breast Cancer AJCC v8; Anatomic Stage IIIB Breast Cancer AJCC v8; Anatomic Stage IIIC Breast Cancer AJCC v8; Lymph Node Involvement; Prognostic Stage II Breast Cancer AJCC v8; Prognostic Stage IIA Breast Cancer AJCC v8; Prognostic Stage IIB Breast Cancer AJCC v8; Prognostic Stage III Breast Cancer AJCC v8; Prognostic Stage IIIA Breast Cancer AJCC v8; Prognostic Stage IIIB Breast Cancer AJCC v8; Prognostic Stage IIIC Breast Cancer AJCC v8
Interventions: Radiation: 3-Dimensional Conformal Radiation Therapy; Radiation: Intensity-Modulated Radiation Therapy
Sponsors: Ohio State University Comprehensive Cancer Center; National Cancer Institute (NCI)
Recruiting
The Effect of Histopathologic Analysis and Tissue Cultures on Inpatient Management of Cellulitis and Pseudocellulitis
NCT03785834
Conditions: Cellulitis; Pseudocellulitis
Intervention: Procedure: Punch Biopsy
Sponsor: Ohio State University
Recruiting
Utilization of the Mirror During Pelvic Exams
NCT03785548
Condition: Pelvic Exam
Intervention: Other: Usage of a mirror
Sponsor: TriHealth Inc.
Recruiting
SASH Study - Sonographic Assessment for Severe Hypertension in Pregnancy
NCT03783169
Condition: Hypertension in Pregnancy
Intervention: Other: Cardiovascular Sonographic Assessment
Sponsor: TriHealth Inc.
Recruiting
Sleep After Adolescent Concussion
NCT03781076
Condition: Brain Concussion
Intervention: Behavioral: Sleep Intervention
Sponsors: Children's Hospital Medical Center, Cincinnati; Cincinnati Children's Research Foundation
Recruiting
Spironolactone Versus Prednisolone in DMD
NCT03777319
Condition: Muscular Dystrophy, Duchenne
Interventions: Drug: Spironolactone; Drug: Prednisolone
Sponsors: Kevin Flanigan; Muscular Dystrophy Association
Recruiting
Prematurity Education in High Risk Pregnancies
NCT03772080
Conditions: Prematurity; High Risk Pregnancy
Intervention: Other: Early counseling of prematurity in high-risk pregnancies.
Sponsors: University Hospitals Cleveland Medical Center; Rainbow Babies and Children's Hospital
Recruiting
Pharmacokinetic and Pharmacodynamic Analysis of Ceftaroline in Children and Adolescents With Cystic Fibrosis
NCT03771313
Condition: Cystic Fibrosis
Intervention: Drug: Ceftaroline
Sponsor: Children's Hospital Medical Center, Cincinnati
Recruiting
Hearing Aid Noise Reduction in Pediatric Users (Oticon Study)
NCT03771287
Conditions: Hearing Impairment; Hearing Loss, Sensorineural
Interventions: Device: Oticon OpenSound Navigator speech enhancement algorithm; Device: Oticon omni-directional microphone algorithm
Sponsors: Children's Hospital Medical Center, Cincinnati; Oticon
Recruiting
Gene Transfer Study of AAV9-CLN3 for Treatment NCL Type 3
NCT03770572
Condition: CLN3-Related Neuronal Ceroid-Lipofuscinosis
Intervention: Biological: AAV9-CLN3
Sponsors: Nationwide Children's Hospital; Amicus Therapeutics
Recruiting
Registry for Advanced Sarcodiosis
NCT03769987
Condition: Sarcoidosis
Intervention: Other: observation
Sponsor: University of Cincinnati
Recruiting

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