Join Clinical Trials in Kentucky

Diagnosis of ON With or Without MS or NMOSD
NCT04131764
Conditions: Multiple Sclerosis; Neuromyelitis Optica Spectrum Disorder Attack; Neuromyelitis Optica Spectrum Disorder Relapse; Neuromyelitis Optica Spectrum Disorder Progression; Optic Neuritis
Intervention: Diagnostic Test: Reflex (Brightlamp Inc., Purdue University)
Sponsor: University of Kentucky
Enrolling by invitation
MS and NMOSD in African-Americans
NCT04131673
Conditions: Multiple Sclerosis; Neuromyelitis Optica
Intervention:
Sponsor: University of Kentucky
Enrolling by invitation
Standing, Stepping and Voluntary Movement Spinal Cord Epidural Stimulation
NCT04123847
Condition: Spinal Cord Injuries
Interventions: Other: Standing and Stepping; Device: Standing, Stepping and Voluntary Movement with spinal cord Epidural Stimulation
Sponsors: Susan Harkema; The Leona M. and Harry B. Helmsley Charitable Trust
Recruiting
Internet Auditory Rehabilitation: Follow-up to Adult Hearing Screening
NCT04122183
Condition: Hearing Loss
Intervention: Other: iManage (my hearing loss)
Sponsors: University of Louisville; William Demant Foundation (Formerly known as the Oticon Foundation)
Not yet recruiting
Gastric Electrical Stimulation for Abdominal Pain in Gastroparesis
NCT04121325
Condition: Abdominal Pain
Intervention: Device: Enterra
Sponsor: University of Louisville
Not yet recruiting
Intra-operative Fraction of Inspired Oxygen and Lung Injury in Coronary Artery Bypass Grafting Surgery
NCT04115501
Conditions: Lung Injury; Pulmonary Complication
Intervention: Other: Fraction of Inspired Oxygen
Sponsors: University of Louisville; Peking Union Medical College Hospital; Tianjin Chest Hospital; Xiangya Hospital of Central South University; Guangdong General Hospital; Second Xiangya Hospital of Central South University; Peking University People's Hospital
Not yet recruiting
Transformation of Paralysis to Stepping
NCT04105114
Condition: Spinal Cord Injuries
Interventions: Drug: Buspirone; Device: Non-invasive Spinal Cord Stimulation; Device: Ekso Bionics Exoskeleton; Device: Gravity Neutral Device; Device: Body Weight Supported Treadmill Training; Device: Rolling Walker
Sponsor: University of Louisville
Not yet recruiting
Timed Exercise Study
NCT04097886
Condition: Circadian Timing - Exercise
Interventions: Other: Morning Exercise; Other: Evening Exercise
Sponsor: Julie Pendergast
Completed
Depression, Trauma, and Health: Efficacy of an mHealth App for Symptom Self-Management in College Students
NCT04094792
Condition: Depression
Intervention: Device: Happify Breather App
Sponsors: University of Kentucky; Happify Inc.
Not yet recruiting
Xoft® Intraoperative Radiotherapy (IORT) for Patients With Early-Stage Breast Cancer
NCT04088435
Conditions: Breast Cancer; Breast Cancer, Invasive Ductal; Invasive Mammary Carcinoma; Breast Cancer Stage I; Breast Cancer Stage IIA
Intervention: Radiation: Intraoperative radiotherapy
Sponsor: University of Louisville
Recruiting
Trial of Neurostimulation and Blood Flow Restriction for PFPS in Active Duty
NCT04086615
Condition: Patellofemoral Pain Syndrome
Interventions: Device: NMES and exercise supplemented with high BFR; Device: NMES and exercise supplemented with low BFR
Sponsors: University of Tennessee; Blanchfield Army Community Hospital
Not yet recruiting
Neuromodulation of Spinal Locomotor Circuitry to Elicit Stepping After Pediatric Spinal Cord Injury
NCT04077346
Condition: Spinal Cord Injuries
Interventions: Device: Biostim-5 transcutaneous spinal stimulator; Other: Activity Based Locomotor Training; Other: Transcutaneous Spinal Stimulator + Activity Based Locomotor Training
Sponsor: University of Louisville
Not yet recruiting
Sodium Watchers Program - Hypertension
NCT04076280
Condition: Hypertension
Interventions: Behavioral: Sodium Watcher Program-Hypertension; Behavioral: Usual Care
Sponsor: Misook L. Chung
Recruiting
A (Prospective/Pilot) Study Evaluating the Effect of Cataract Surgery on the Daily Activity Levels of Elderly Patients
NCT04074954
Conditions: Cataract; Diabetes; Hypertension; Obesity; Vision Disability
Intervention: Procedure: Cataract surgery
Sponsor: University of Pikeville
Recruiting
Redefining Survivorship: POWER to Maximize Physical Function for Survivors of Critical Illness
NCT04058977
Conditions: Critical Illness; Muscle Atrophy or Weakness
Intervention: Other: Power training
Sponsors: University of Kentucky; Nathan Johnson, PT, PhD; Ashley Montgomery-Yates, MD; Amy Pastva, PT, PhD; Peter E. Morris, MD
Not yet recruiting
Transcutaneous Spinal Stimulation: Safety and Feasibility for Upper Limb Function in Children With Spinal Cord Injury
NCT04032990
Condition: Spinal Cord Injuries
Intervention: Device: Biostim-5 transcutaneous spinal stimulator
Sponsors: University of Louisville; The Jewish Heritage Foundation for Excellence
Not yet recruiting
A Study to Evaluate the Safety and Effectiveness Assessments of Restylane-Defyne for Punctual Occlusion
NCT04022382
Condition: Dry Eye
Intervention: Device: Restylane Defyne
Sponsor: John C Meyer, MD
Completed
Total Knee Replacement With Tourniquet or Aquamantys
NCT04016285
Condition: Knee Replacement
Interventions: Device: Aquamantys; Device: Tourniquet
Sponsors: Stephen Duncan; Medtronic
Recruiting
Adrenergic Cholinergic Enteric Measures/Mapping
NCT04013282
Condition: Obesity
Intervention:
Sponsor: University of Louisville
Recruiting
Hydroxychloroquine to Increase Tumor Suppressor PAR-4 Levels in Oligometastatic Prostate Cancer
NCT04011410
Condition: Prostate Cancer Recurrent
Intervention: Drug: Hydroxychloroquine Sulfate 200Mg Tab
Sponsor: University of Kentucky
Not yet recruiting
Testing a Smart Phone App to Enhance Voice Therapy Adherence
NCT04002336
Condition: Voice Disorders
Interventions: Behavioral: Traditional Voice therapy; Behavioral: Voice Therapy App
Sponsor: Vrushali Angadi
Completed
Effects of 5HTP and LDOPA on CNS Excitability After SCI
NCT04000919
Condition: Spinal Cord Injuries
Interventions: Drug: 5HTP; Drug: L-DOPA; Drug: Placebo oral tablet; Drug: Carbidopa
Sponsor: Jessica M D'Amico
Recruiting
Non-Invasive Spinal Cord Stimulation After Injury
NCT03998527
Condition: Spinal Cord Injuries
Intervention: Device: Transcutaneous Electrical Spinal Cord Stimulation (TcESCS)
Sponsor: University of Louisville
Recruiting
Study of Lumbar Discectomy With Annular Closure
NCT03986580
Condition: Lumbar Disc Herniation
Intervention: Device: BARRICAID device
Sponsor: Intrinsic Therapeutics
Not yet recruiting
Study of Regional Cerebral Oxygenation and Brain Blood Volume Changes During Carotid Endarterectomy Using the NeurOS System
NCT03981757
Condition: Carotid Disease
Intervention: Device: NeurOS
Sponsor: University of Louisville
Recruiting
Transcutaneous Spinal Stimulation: Safety and Feasibility for Trunk Control in Children With Spinal Cord Injury
NCT03975634
Condition: Spinal Cord Injuries
Intervention: Device: Transcutaneous Spinal Stimulation
Sponsors: University of Louisville; National Center of Neuromodulation for Rehabilitation (NM4R)
Recruiting
Regional Cerebral Oxygenation and Brain Blood Volume During Cardiac Surgery Using the NeurOS System
NCT03969836
Condition: Heart Diseases
Intervention: Device: NeurOS system
Sponsor: University of Louisville
Recruiting
Neurobehavioral Mechanisms of Choice in Opioid Use Disorder
NCT03958474
Condition: Opioid Use Disorder
Intervention: Drug: Oxycodone
Sponsor: Joshua A. Lile, Ph.D.
Recruiting
Combination Rucaparib With Nivolumab in Small Cell Lung Carcinoma
NCT03958045
Condition: Small Cell Lung Cancer
Intervention: Combination Product: Rucaparib and Nivolumab
Sponsor: Aman Chauhan
Recruiting
Behavioral Effects of Drugs (Inpatient): 38
NCT03954938
Condition: Cocaine Use, Unspecified
Interventions: Behavioral: Craving Manipulation; Drug: Cocaine; Drug: Placebo
Sponsor: William Stoops
Recruiting
Improving Hand Recovery With Neuromodulation in Tetraplegia
NCT03954496
Conditions: Spinal Cord Injuries; Tetraplegia, Unspecified, Incomplete, Chronic
Interventions: Device: transcranial direct current stimulation; Behavioral: Intensive upper extremity motor training
Sponsors: University of Kentucky; Wings for Life - spinal cord research foundation
Recruiting
Better Together: A Web-based Relationship Education Tool
NCT03953495
Condition: Same-Sex Relationships
Interventions: Behavioral: Better Together; Behavioral: Better Together (delayed)
Sponsor: Sharon Scales Rostosky
Recruiting
The Kentucky Viral Hepatitis Treatment Study
NCT03949764
Conditions: Hepatitis C; Opioid-Related Disorders; Injection Drug Use
Intervention: Drug: Sofosbuvir/velpatasvir (Epclusa®)
Sponsors: Jennifer Havens; National Institute on Drug Abuse (NIDA); National Cancer Institute (NCI); Gilead Sciences; University of Kentucky; Icahn School of Medicine at Mount Sinai; University of Bristol
Not yet recruiting
Neural Mechanisms of Cannabinoid-impaired Decision-Making in Emerging Adults
NCT03944954
Conditions: Neurosciences; Substance-Related Disorders; Behavior Problem
Interventions: Drug: Marinol; Device: Transcranial Magnetic Stimulation
Sponsor: University of Kentucky
Recruiting
Tourniquet vs. Short Time Tourniquet in Primary Robotic Assisted TKA
NCT03942939
Condition: Knee Arthropathy
Interventions: Other: Primary Robotic-Assisted Total Knee Arthroplasty with a short tourniquet time; Other: Primary Robotic-Assisted Total Knee Arthroplasty with the use of a tourniquet
Sponsor: University of Louisville
Recruiting
Fetal Life: Smart-Device Based Uterine Activity Monitoring
NCT03940365
Conditions: Labor Pain; Contraction
Intervention: Device: Fetal Life tocometer device
Sponsors: Fetal Life LLC; University of Louisville
Not yet recruiting
Suvorexant and Cocaine
NCT03937986
Condition: Cocaine Use Disorder
Interventions: Drug: Suvorexant; Drug: Cocaine; Drug: Placebo oral capsule
Sponsors: William Stoops; National Institute on Drug Abuse (NIDA)
Recruiting
Imaginal Exposure II Study: In-Vivo
NCT03934697
Conditions: Eating Disorder; Anorexia Nervosa; Bulimia Nervosa; Exposure
Intervention: Behavioral: imaginal exposure therapy
Sponsor: University of Louisville
Recruiting
Gentamicin Bladder Instillation in Individuals With Spinal Cord Injury Having Chronic Urinary Tract Infections
NCT03931408
Conditions: Neurogenic Bladder; Spinal Cord Injuries
Interventions: Drug: Gentamicin Sulfate; Other: Placebo instillation (saline alone); Other: No instillation
Sponsor: University of Louisville
Recruiting
DUR-928 in Patients With Alcoholic Hepatitis
NCT03917407
Condition: Alcoholic Hepatitis
Interventions: Drug: DUR-928 (Moderate AH); Drug: DUR-928 (Severe AH)
Sponsors: Craig James McClain; National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Not yet recruiting
Durvalumab and Tremelimumab Combination in Somatically Hypermutated Recurrent Solid Tumors
NCT03911557
Condition: Tumor, Solid
Intervention: Drug: Durvalumab and Tremelimumab
Sponsor: John L. Villano, MD, PhD
Recruiting
Role of ASpirin in Placental and Maternal Endothelial Cell Regulation IN Pre-eclampsia
NCT03893630
Condition: Pre-Eclampsia
Interventions: Drug: Acetylsalicylic Acid 81 mg; Drug: Acetylsalicylic Acid 162 mg; Other: Control
Sponsor: John O'Brien, MD
Recruiting
Intramedullary Bone Grafting for Open Tibial Shaft Fractures
NCT03891888
Conditions: Tibial Fractures; Nonunion of Fracture; Delayed Union of Fracture
Intervention: Procedure: Intramedullary Bone Graft
Sponsor: University of Louisville
Not yet recruiting
Valproic Acid and Dihydroergotamine as Abortive Therapy in Pediatric Migraine
NCT03885154
Condition: Migraine in Children
Interventions: Drug: Valproic Acid (VPA); Drug: Dihydroergotamine (DHE)
Sponsor: Kimberly S Jones
Recruiting
Prospective, Multi-center Study to Assess Posterolateral Fusion Using FIBERGRAFT
NCT03884283
Conditions: Degenerative Disc Disease; Spondylolisthesis; Spinal Stenosis Lumbar
Intervention: Device: FIBERGRAFT BG Matrix
Sponsor: Prosidyan, Inc.
Enrolling by invitation
Gastroparesis Outcome Longitudinal Database Enrolled Numerically
NCT03876288
Condition: Gastroparesis
Interventions: Device: GI Neuromodulation; Drug: Immunotherapy; Procedure: Pyloric Therapies
Sponsor: University of Louisville
Recruiting
Assessment of Gut Absorption of Experimental Medication BMS-986165 in Healthy Males
NCT03873415
Condition: Psoriasis
Intervention: Drug: BMS-986165
Sponsor: Bristol-Myers Squibb
Completed
Clinical Trial on the Preventive Effect of Intravaginal Prasterone on Recurrent Urinary Tract Infections in Postmenopausal Women
NCT03854396
Conditions: Recurrent Urinary Tract Infection; Postmenopause; Postmenopausal Syndrome; Postmenopausal Symptoms; Menopause
Interventions: Drug: Prasterone; Drug: Placebo
Sponsors: Olivia Cardenas-Trowers, M.D.; AMAG Pharmaceuticals, Inc.
Not yet recruiting
The Effect of Enstilar Versus Vehicle on Target Lesions in Moderate Plaque Type Psoriasis Patients
NCT03848871
Condition: Plaque Psoriasis
Intervention: Drug: Enstilar
Sponsor: Derm Research, PLLC
Completed
Intraoral Administration of Botox in Patients With Dentoalveolar Neuropathic Pain
NCT03848143
Condition: Neuropathic Pain
Intervention: Drug: onabotulinum toxin A
Sponsors: Isabel Moreno Hay; Allergan Sales, LLC
Recruiting
ACB + IPACK Block With or Without Local Infiltration in RA-TKA
NCT03840122
Condition: Knee Arthropathy
Interventions: Other: ACB + IPACK block with injection of local anesthetic; Other: ACB + IPACK block without injection
Sponsor: University of Louisville
Withdrawn
Dietary Intervention in Persons With Metabolic Syndrome
NCT03836651
Condition: Metabolic Syndrome
Interventions: Other: Dietary Antioxidant (V8® Low Sodium 100% vegetable juice); Other: Control group
Sponsor: Martha Biddle
Recruiting
Oral Health Promotion Strategy for Persons With Intellectual/Developmental Disabilities
NCT03834064
Condition: Oral Health
Intervention: Behavioral: Oral health promotion strategy
Sponsors: University of Louisville; National Institute of Dental and Craniofacial Research (NIDCR)
Enrolling by invitation
Transvaginal Ultrasound: Preterm Birth in Appalachia
NCT03833284
Condition: Preterm Birth
Interventions: Behavioral: Participant Barriers to TVU Screening; Behavioral: Provider Barriers to TVU Screening
Sponsor: Niraj Chavan
Recruiting
Behavioral and Enhanced Perinatal Intervention for Cessation (B-EPIC): Reducing Tobacco Use Among Opioid Addicted Women
NCT03796208
Condition: Smoking Cessation
Interventions: Behavioral: Behavioral and Enhanced Perinatal Intervention for Cessation (B-EPIC); Behavioral: Treatment As Usual
Sponsors: Kristin Ashford; National Institute on Drug Abuse (NIDA)
Recruiting
Antidepressant Discontinuation in Treatment Resistant Depression
NCT03786614
Condition: Treatment Resistant Depression
Interventions: Other: Discontinuation of serotonergic antidepressants; Other: Continuation of serotonergic medications
Sponsor: University of Louisville
Not yet recruiting
Impact of SPEAC® System Data on Therapeutic Decisions Related to Convulsive Seizure Patients With a New Diagnosis
NCT03742661
Condition: Epilepsy
Intervention: Device: SPEAC System
Sponsor: Brain Sentinel
Active, not recruiting
Pentamidine + Salvage Chemo for Relapsed/Refractory Classical Hodgkin Lymphoma
NCT03730363
Conditions: Hodgkin Lymphoma; Refractory Hodgkin Lymphoma
Intervention: Drug: Pentamidine
Sponsor: University of Kentucky
Recruiting
HO Prophylaxis Therapy for Distal Humerus Fractures
NCT03724422
Conditions: Heterotopic Ossification; Humeral Fractures; Radiation Therapy
Intervention: Radiation: Radiation
Sponsor: University of Louisville
Not yet recruiting
Evaluating an Amino Acid Based Medical Food w/ Diarrhea in Carcinoid Syndrome & Other NETs
NCT03722511
Conditions: Neuroendocrine Tumors; Carcinoid Tumor of GI System; Diarrhea; Carcinoid Syndrome
Intervention: Dietary Supplement: Amino Acid Based Medical Food/Drink
Sponsors: University of Kentucky; Entrinsic Health Solutions, Inc.
Recruiting
Muscle Dysfunction in Critical Illness
NCT03717831
Conditions: Critical Illness; Intensive Care (ICU) Myopathy; PICS; Muscle Weakness
Intervention:
Sponsor: University of Kentucky
Recruiting
Online Imaginal Exposure
NCT03712748
Conditions: Eating Disorder; Exposure; Anorexia Nervosa; Bulimia Nervosa; Binge-Eating Disorder; Therapy
Intervention: Behavioral: Imaginal Exposure therapy
Sponsor: University of Louisville
Recruiting
A Study to Evaluate the Safety and Effectiveness of Restylane-Defyne for Punctual Occlusion
NCT03709641
Condition: Mild to Moderate Dry Eye Disease
Intervention: Device: Restylane Defyne
Sponsor: John C Meyer, MD
Completed
Treatment of FUS-Related ALS With Betamethasone - The TRANSLATE Study
NCT03707795
Condition: Familial Amyotrophic Lateral Sclerosis
Intervention: Drug: Betamethasone sodium phosphate/betamethasone acetate (Celestone® Soluspan®), 30 mg IM once a day for four days
Sponsor: University of Kentucky
Recruiting
Opioid and Cannabinoid Interactions
NCT03705559
Conditions: Marijuana Usage; Opioid Use
Interventions: Drug: Vaporized Marijuana; Drug: Opioid Agonist
Sponsor: Shanna Babalonis, PhD
Recruiting
Marijuana Effects on Simulated Driving Performance
NCT03699540
Conditions: Cannabis; Cannabis Use; Marijuana; Marijuana Usage; Alcohol Drinking
Interventions: Drug: Marijuana; Drug: Alcohol
Sponsor: Shanna Babalonis, PhD
Recruiting
WoundVac in Obese Patients Undergoing Lumbar Surgery
NCT03688438
Conditions: Obesity; Lumbar Spine Surgery
Intervention: Device: Closed-Incision Negative-Pressure Therapy
Sponsor: Norton Leatherman Spine Center
Not yet recruiting
CAMS-G Group Therapy for Suicidal Veterans
NCT03682406
Condition: Suicide and Self-harm
Intervention: Behavioral: CAMS-G
Sponsors: Louisville VA Medical Center; Rocky Mountain MIRECC for Suicide Prevention
Recruiting
Health, Environment and Action in Louisville (HEAL) Green Heart Louisville Project
NCT03670524
Conditions: Cardiovascular Diseases; Metabolic Health
Intervention: Other: Greenness as a therapeutic intervention
Sponsors: University of Louisville; National Institute of Environmental Health Sciences (NIEHS); The Nature Conservancy
Recruiting
Elbow Arthroscopy Data Analysis
NCT03656185
Conditions: Osteoarthritis Elbow Left; Osteoarthritis Elbow Right; Lateral Epicondylitis, Left Elbow; Lateral Epicondylitis, Right Elbow; Plica Syndromes; Osteochondritis Dissecans
Intervention:
Sponsor: The Orthopaedic Research & Innovation Foundation
Active, not recruiting
The ASTERS Study: Assessing the Role of Sphingolipids in AcuTE Respiratory Distress Syndrome (ARDS)
NCT03654352
Conditions: Acute Lung Injury; Acute Respiratory Distress Syndrome
Intervention:
Sponsor: University of Kentucky
Recruiting
Neuro-ocular Baselines in a Sports Setting
NCT03653936
Condition: Wave Form Signals Coming From the Eye in a Healthy Cohort
Intervention: Device: HITT device
Sponsors: Rebiscan, Inc.; BlueGrass Orthopaedics Surgery & Hand Care
Completed
Patient Satisfaction With Postoperative Follow up After Minimally Invasive Hysterectomy
NCT03642743
Conditions: Minimally Invasive Surgery; Hysterectomy; Postoperative; Satisfaction
Intervention: Other: postoperative follow up appointment
Sponsor: University of Louisville
Recruiting
Retrospective Analysis on Distal Humerus Fractures
NCT03637621
Condition: Distal Humerus Fracture
Intervention: Other: ORIF
Sponsor: The Orthopaedic Research & Innovation Foundation
Active, not recruiting
Proximal Humerus Fractures: A Retrospective Analysis
NCT03637608
Condition: Proximal Humeral Fracture
Intervention:
Sponsor: The Orthopaedic Research & Innovation Foundation
Active, not recruiting
Iron Dosing Pilot Study Using Model Predictive Control
NCT03633656
Conditions: Renal Insufficiency, Chronic; Anemia, Iron Deficiency; Anemia of Chronic Kidney Disease
Intervention: Device: Model predictive control
Sponsor: University of Louisville
Not yet recruiting
Incontinence Management System ICU Field Evaluation
NCT03628833
Conditions: Urinary Incontinence; Fecal Incontinence
Intervention: Device: Incontinence Management System
Sponsor: Hill-Rom
Completed
Posterior Approach to Total Shoulder Arthroplasty
NCT03623269
Conditions: Total Shoulder Arthroplasty; Osteo Arthritis Shoulders
Intervention: Procedure: posterior approach to total shoulder arthroplasty
Sponsor: The Orthopaedic Research & Innovation Foundation
Active, not recruiting
Functional and Self-reported Outcomes in Participants With a History of Musculoskeletal Knee Injury
NCT03617991
Conditions: Anterior Cruciate Ligament Injury; Anterior Cruciate Ligament Rupture
Intervention: Other: Exercise Group
Sponsor: Johanna M. Hoch
Recruiting
Reverse Total Shoulder Arthroplasty: A Data Analysis on Patients Undergoing Reverse Total Shoulder Arthroplasty
NCT03617107
Conditions: Osteo Arthritis Shoulders; Proximal Humeral Fracture; Rotator Cuff Tear; Rotator Cuff Tear Arthropathy
Intervention: Other: reverse total shoulder arthroplasty
Sponsor: The Orthopaedic Research & Innovation Foundation
Active, not recruiting
Does Depth of Neuromuscular Blockade (NMB) Affect Surgical Conditions in Obese Patients Undergoing Robotic Surgery
NCT03591289
Conditions: GYN Disorders; Urologic Diseases
Intervention: Drug: NMB with rocuronium bromide
Sponsor: Rainer Lenhardt
Recruiting
Root Coverage With Acellular Dermal Matrix and Bovine Derived Osseous
NCT03582995
Condition: Recession, Gingival
Interventions: Procedure: Flap Surgery for root coverage with Alloderm and xenograft; Procedure: Tunnel Surgery for root coverage with Alloderm and xenograft
Sponsor: University of Louisville
Not yet recruiting
Community Access, Retention in Care, and Engagement for Hepatitis C Treatment
NCT03581383
Condition: Hepatitis C
Interventions: Behavioral: PREP-C; Behavioral: Modified ECHO
Sponsor: Jens Rosenau
Recruiting
Clinical Effects of Hard and Soft Tissue Grafting With Dental Implants
NCT03580811
Condition: Dental Implants
Interventions: Device: Dental Implant &ADMG; Device: Dental implant & ADMG & BDX
Sponsor: University of Louisville
Not yet recruiting
Behavioral Effects of Drugs: Inpatient (36) (Alcohol, Duloxetine, and Methylphenidate)
NCT03575403
Condition: Alcohol Use Disorder
Interventions: Drug: Alcohol; Drug: Placebos; Drug: Duloxetine; Drug: Methylphenidate
Sponsors: Craig Rush; National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Recruiting
Building Stronger Allies
NCT03571750
Conditions: Suicide; Risk Reduction
Interventions: Behavioral: Building Stronger Allies; Behavioral: Health Education Training
Sponsor: Florida State University
Recruiting
Tanglewood to Table: A Walking Farmer's Market Group and Control
NCT03567252
Condition: Dietary Habits
Intervention: Behavioral: Walking Group
Sponsors: Dawn Brewer; National Institute of Environmental Health Sciences (NIEHS)
Completed
A Review of Low-Dose CT Lung Cancer Screenings in a Community-Based Healthcare System With High Incidence
NCT03560791
Condition: Non-small Cell Lung Cancer
Intervention:
Sponsor: St Elizabeth Healthcare
Enrolling by invitation
Effects of Family Sodium Watcher Program on Outcomes in Heart Failure Patient-Family Caregiver Dyads
NCT03560206
Condition: Heart Failure
Interventions: Behavioral: Family SWaP intervention with mini iPad; Behavioral: usual care
Sponsor: Misook L. Chung
Active, not recruiting
Increasing PrEP Among African Americans in Louisville KY
NCT03559595
Condition: HIV/AIDS PREVENTION
Intervention: Behavioral: Project Prevent
Sponsor: University of Louisville
Recruiting
Pediatric Locomotor Training Bladder Study
NCT03559036
Conditions: Spinal Cord Injuries; Neurogenic Bladder
Intervention: Procedure: Locomotor Training
Sponsors: University of Louisville; The Leona M. and Harry B. Helmsley Charitable Trust; Kosair Charities, Inc.
Recruiting
Neural Correlates of Self-regulation on Academic Functioning
NCT03549377
Condition: Self-Control
Intervention: Behavioral: Deception
Sponsor: Alexander Vazsonyi
Completed
An Analysis of Treatment Timelines for Lung Cancer Patients Across System Evolutions
NCT03535766
Condition: Lung Cancer
Intervention:
Sponsor: St Elizabeth Healthcare
Enrolling by invitation
Teachable Moment Brief Intervention for Veterans Following a Suicide Attempt
NCT03533075
Condition: Suicide, Attempted
Intervention: Behavioral: Teachable Moment Brief Intervention
Sponsors: Louisville VA Medical Center; University of Louisville
Active, not recruiting
Idiopathic Parkinson's Progression and Dopamine Transporter SPECT
NCT03531086
Condition: Parkinson Disease
Intervention: Drug: Ioflupane I 123
Sponsor: Julie Gurwell
Recruiting
Behavioral Effects of Drugs: Inpatient (35)
NCT03519022
Condition: Cocaine Use Disorder
Interventions: Drug: Cocaine; Drug: Placebo oral capsule; Drug: Methylphenidate
Sponsors: Craig Rush; National Institute on Drug Abuse (NIDA)
Completed
The Role of Physical Activity During Pregnancy on Metabolic Function, Inflammation, and Maternal and Neonatal Outcomes
NCT03504319
Conditions: Obesity; Pregnancy Related
Intervention: Other: Exposure to high-fat smoothie
Sponsor: Western Kentucky University
Active, not recruiting
Evidence-based Educational Materials and Local Resources for Improving Exercise-related Outcomes During Pregnancy
NCT03504267
Conditions: Pregnancy Related; Obesity
Intervention: Other: Physical Activity Education and Resources
Sponsor: Western Kentucky University
Completed
Subacute Low Back Pain in Active Duty
NCT03502187
Condition: Subacute Low Back Pain
Interventions: Behavioral: Progressive Exercise Plan; Device: NeuromuscularElectricalStimulation(NMES); Behavioral: Primary Care Management (PCM)
Sponsors: University of Tennessee; Blanchfield Army Community Hospital
Recruiting
An Interactive Text-Message Based Brief Intervention to Reduce Substance-Impaired Driving Among College Students
NCT03496129
Condition: Alcohol-Impaired Driving
Interventions: Behavioral: Personalized feedback; Behavioral: Personalized feedback and text messages; Behavioral: Information Only
Sponsor: Western Kentucky University
Enrolling by invitation
Tanglewood Trail Walking Program in Rural Kentucky
NCT03495648
Condition: Dietary Habits
Interventions: Behavioral: walking group led by a community organizer; Behavioral: Drive
Sponsors: Dawn Brewer; National Institute of Environmental Health Sciences (NIEHS)
Active, not recruiting
Plant Exosomes and Patients Diagnosed With Polycystic Ovary Syndrome (PCOS) 17
NCT03493984
Condition: Polycystic Ovary Syndrome
Interventions: Other: Ginger exosomes; Other: Aloe exosomes; Other: Placebo
Sponsor: University of Louisville
Recruiting
A 14 Weeks Longitudinal Study to Investigate the Effect of Leukocyte- Platelet Rich Fibrin Plug on the Quality of the Newly Formed Bone in Ridge Preservation Procedure Following a Tooth Extraction. It is a Clinical, Radiographic and Histomorphometric Study.
NCT03487718
Conditions: Alveolar Ridge Preservation; Tooth Extraction
Interventions: Biological: Leukocyte platelet rich fibrin plug + d-PTFE membrane; Biological: d-PTFE membrane
Sponsor: Firas Al Yafi
Recruiting
Chemotherapy and Irreversible Electroporation in the Treatment of Advanced Pancreatic Adenocarcinoma
NCT03484299
Condition: Pancreas Cancer
Interventions: Procedure: Irreversible Electroporation (IRE); Drug: Gemcitabine; Drug: FOLFIRINOX
Sponsor: University of Louisville
Recruiting
Adaptation and Pilot Testing of a Behavioral Parent Training Program for Parents of Deaf and Hard of Hearing Children
NCT03483428
Conditions: Hearing Loss; Behavior Disorders; Parenting
Interventions: Behavioral: Interventionist training and supervision; Behavioral: Behavioral parent training
Sponsor: University of Kentucky
Completed
BerryCare: A Community Engagement Program
NCT03477305
Condition: Cardiovascular Risk Factor
Intervention: Behavioral: Blackberry Consumption
Sponsors: Dawn Brewer; National Institute of Environmental Health Sciences (NIEHS)
Completed
Clinic to Community Navigation to Improve Diabetes Outcomes
NCT03474731
Condition: Diabetes Mellitus
Interventions: Behavioral: Diabetes Self Management Program; Behavioral: Tailored Patient Navigation (PN) only; Behavioral: DSMP AND Tailored Patient Navigation
Sponsor: Nancy Schoenberg
Recruiting
Promoting Colorectal Cancer Screening in Rural Emergency Departments
NCT03473587
Condition: Colorectal Cancer
Interventions: Behavioral: Motivational interview; Behavioral: Standard of care
Sponsor: University of Kentucky
Recruiting
Clinical Trial Comparing Two Bladder Instillations for IC/BPS
NCT03463915
Conditions: Interstitial Cystitis; Bladder Pain Syndrome
Interventions: Drug: Bladder instillation WITH triamcinolone acetonide; Drug: Bladder instillation WITHOUT triamcinolone acetonide
Sponsor: Olivia Cardenas-Trowers, M.D.
Recruiting
The Use of Oracea and Epiduo Forte in Severe Acne Patients
NCT03457636
Condition: Acne
Interventions: Drug: Doxycycline Anhydrous 40 MG; Drug: Adapalene/Benzoyl Peroxide Gel 0.3-2.5%
Sponsor: Derm Research, PLLC
Completed
Social Media HIV Prevention Intervention for High Risk Rural Women
NCT03456453
Condition: HIV/AIDS
Intervention: Behavioral: NIDA Standard for HIV Prevention
Sponsors: University of Kentucky; National Institute on Drug Abuse (NIDA)
Recruiting
SPARC Bladder Mapping and Training Study
NCT03452007
Condition: Spinal Cord Injuries
Intervention: Device: Epidural Stimulation
Sponsor: University of Louisville
Recruiting
Re-entry XR-NTX for Rural Women With Opioid Use Disorder
NCT03447743
Condition: Opioid Dependence
Intervention: Drug: XR-NTX community location
Sponsor: University of Kentucky
Recruiting
Study Investigating Role of Unalike Patient Positioning on PROMIS Scores
NCT03446950
Conditions: Physical Activity; Surgery; Vaginal Hysterectomy; Vaginal Surgery
Intervention: Procedure: Vaginal Surgery
Sponsor: University of Louisville
Recruiting
Tobacco Use in Pregnancy Intervention for Cessation
NCT03442530
Condition: Pregnancy
Interventions: Behavioral: ToPIC; Behavioral: Tobacco Treatment As Usual (TTAU)
Sponsors: Kristin Ashford; University of Kentucky
Active, not recruiting
Brief Online Interventions for Alcohol Use
NCT03438539
Condition: Alcohol Use Disorder
Interventions: Behavioral: Normative Feedback; Behavioral: Inhibitory Control Training; Behavioral: Working Memory Training
Sponsors: Craig Rush; National Institute on Drug Abuse (NIDA)
Recruiting
Early Anti-inflammatory Treatment in Patients With Acute ACL Tear and Painful Effusions
NCT03429140
Condition: Anterior Cruciate Ligament
Interventions: Drug: Gel-One; Other: Saline Placebo
Sponsor: Mary Ireland
Active, not recruiting
Socket Preservation: A Clinical and Histological Study
NCT03422692
Condition: Alveolar Ridge Augmentations
Interventions: Biological: BioXclude amnion-chorion membrane; Biological: Mem-Lok collagenous membrane
Sponsor: University of Kentucky
Completed
"Assessment of the Quality and Quantity of Bone Regeneration."
NCT03417375
Condition: Bone Quality and Quantity
Intervention: Procedure: Bilateral Sinus Augmentation
Sponsor: University of Kentucky
Active, not recruiting
To Investigate the Gastrointestinal Behaviour of Two Triple Combination Products in Healthy Male Volunteers
NCT03415243
Condition: Common Cold
Interventions: Drug: Acetaminophen 650mg+Dextromethorphan 20mg+Phenylephrine 10mg; Drug: Acetaminophen 325mg+Dextromethorphan 10mg+Phenylephrine 5mg
Sponsor: GlaxoSmithKline
Completed
Exercise and Weight Control
NCT03413826
Conditions: Obesity; Exercise Reinforcement
Intervention: Behavioral: Exercise
Sponsor: University of Kentucky
Completed
The Use of Onexton in Moderate Acne Vulgaris for Patients With Skin of Color
NCT03402893
Conditions: Acne Vulgaris; Post Inflammatory Hyperpigmentation
Intervention: Drug: ONEXTON Topical Gel
Sponsor: Derm Research, PLLC
Completed
Non-Opiate Treatment After Prenatal Opiate Exposure to Prevent Postnatal Injury to the Young Brain
NCT03396588
Condition: Neonatal Abstinence Syndrome
Interventions: Drug: Clonidine; Drug: Morphine
Sponsors: University of Kentucky; National Institute on Drug Abuse (NIDA)
Recruiting
Thick vs. Thin Acellular Dermal Matrix (ADM)
NCT03392038
Condition: Gingival Recession
Interventions: Procedure: Thin ADM; Procedure: Thick ADM
Sponsor: University of Louisville
Recruiting
Telemedicine-based, Multidisciplinary-team, Intervention to Reduce Unnecessary Hospitalizations
NCT03378245
Conditions: Dementia Alzheimers; Disruptive Behavior
Intervention: Behavioral: Behavioral modification and education on pharmacologic treatments.
Sponsor: Richard Ronan Murphy
Suspended
Task-specific Epidural Stimulation Study
NCT03364660
Condition: Spinal Cord Injuries
Interventions: Device: Epidural Stimulation; Biological: Stand Training
Sponsor: University of Louisville
Recruiting
The PSVT Place Registry.Paroxysmal Supraventricular Tachycardia (PSVT) Registry.
NCT03353610
Condition: Paroxysmal Supraventricular Tachycardia (PSVT)
Intervention:
Sponsor: Milestone Pharmaceuticals Inc.
Recruiting
Toxicity & Pharmacokinetics of 2 & 3-weekly Docetaxel in Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)
NCT03343977
Condition: Metastatic Hormone-Sensitive Prostate Cancer
Interventions: Drug: docetaxel 50mg/m2; Drug: docetaxel 75mg/m2
Sponsor: Peng Wang, MD PhD
Withdrawn
Chemotherapy-Induced Cognitive Impairment in Ovarian Cancer Patients
NCT03324945
Condition: Chemotherapy-induced Cognitive Impairment
Intervention: Behavioral: Neurocognitive assessments
Sponsors: University of Kentucky; Office of US Army Medical Research and Material Command
Active, not recruiting
Impact of Envarsus XR® on Kidney Biopsy Subclinical Rejection and Blood Immunologic Profile
NCT03321656
Condition: End Stage Renal Disease
Interventions: Drug: Tacrolimus; Drug: Envarsus XR
Sponsors: Roberto Gedaly; Veloxis Pharmaceuticals
Recruiting
Consultation, Advice, and Tailored Support (CATS) for Cancer Survivors
NCT03316170
Conditions: Smoking Cessation; Social Stress
Interventions: Behavioral: Social Support; Drug: NRT Sampling
Sponsors: Jessica Burris; Kentucky Lung Cancer Research Program
Recruiting
Priming Immunotherapy in Advanced Disease With Radiation
NCT03313804
Conditions: Non-small Cell Lung Cancer; Squamous Cell Carcinoma of the Head and Neck
Interventions: Drug: Immune checkpoint inhibitor; Radiation: Radiation Therapy
Sponsor: John L. Villano, MD, PhD
Recruiting
Sedative-Anxiolytic Effects on Simulated Driving Performance
NCT03297944
Condition: Psychomotor Impairment
Interventions: Drug: Alprazolam; Drug: Zolpidem; Drug: Placebo
Sponsors: Marion Coe; National Institute on Drug Abuse (NIDA)
Completed
Dysregulated CNS Inflammation After Acute Brain Injury
NCT03287557
Conditions: Traumatic Brain Injury; Aneurysmal Subarachnoid Hemorrhage
Intervention:
Sponsor: University of Kentucky
Completed
A Pilot Study Using Autologous Regulatory T Cell Infusion Zortress (Everolimus) in Renal Transplant Recipients
NCT03284242
Conditions: End Stage Renal Disease; Kidney Transplant
Intervention: Procedure: Apheresis
Sponsors: Roberto Gedaly; Novartis Pharmaceuticals
Recruiting
Removable Partial Denture Abutments Restored With Monolithic Zirconia Crowns
NCT03283709
Conditions: Crowns; Denture
Interventions: Device: Full-contour monolithic zirconia abutment crowns; Device: Conventional abutment crowns
Sponsor: University of Kentucky
Recruiting
Assessing Repeat Fit Testing for CRC
NCT03248661
Condition: Colo-rectal Cancer
Intervention: Behavioral: Now I'm Telling You
Sponsors: Richard Crosby; Centers for Disease Control and Prevention
Completed
Mantra Meditation in Subjects That Have Chronically Impaired Attention After Stroke
NCT03229902
Condition: Stroke Sequelae
Intervention: Behavioral: mantra meditation
Sponsor: Cheryl Carrico
Completed
Cocaine Use Reduction and Health
NCT03224546
Condition: Cocaine Use Disorder
Intervention: Behavioral: Contingency Management
Sponsors: William Stoops; National Institute on Drug Abuse (NIDA)
Recruiting
Intraoperative Amiodarone to Prevent Atrial Fibrillation in Lung Transplant Patients
NCT03221764
Conditions: Atrial Fibrillation; Lung Transplant; Complications
Interventions: Drug: Amiodarone with CoSeal; Device: CO2 driver
Sponsor: University of Louisville
Completed
Influence of n-Acetylcysteine Maintenance on Alcohol Effects
NCT03216954
Condition: Alcohol Use Disorder
Interventions: Drug: Alcohol; Drug: Placebos; Drug: N-acetyl cysteine
Sponsors: William Stoops; National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Recruiting
Corazon de la Familia (Heart of the Family)
NCT03196024
Conditions: Risk Reduction Behavior; Diabetes Mellitus, Type 2; Cardiovascular Diseases
Interventions: Behavioral: Family-focused intervention arm; Behavioral: Individual-focused intervention arm
Sponsors: University of Kentucky; National Institute of Nursing Research (NINR); National Institutes of Health (NIH)
Recruiting
Evaluation of the Efficacy and Safety of Bempedoic Acid (ETC-1002) 180mg When Added to PCSK9 Inhibitor Therapy
NCT03193047
Condition: Hypercholesterolemia
Interventions: Drug: bempedoic acid 180mg; Other: placebo; Drug: evolocumab
Sponsor: Esperion Therapeutics
Completed
The Efficacy of Single Coil Defibrillation Leads for Internal Cardioversion of Atrial Fibrillation
NCT03164395
Condition: Atrial Fibrillation
Interventions: Procedure: Internal Cardioversion; Procedure: External Cardioversion
Sponsor: University of Kentucky
Completed
Using CPAP to Improve Menstruation in Women With Polycystic Ovarian Syndrome and Obstructive Sleep Apnea
NCT03155828
Conditions: Sleep Apnea, Obstructive; Anovulation; Polycystic Ovarian Syndrome
Intervention: Device: CPAP
Sponsor: University of Louisville
Withdrawn
Initial Evaluation of the Cellie Coping Kit for Children With Injury
NCT03153696
Condition: Injuries
Intervention: Behavioral: Cellie Coping Kit Intervention
Sponsors: University of Kentucky; Children's Hospital of Philadelphia
Active, not recruiting
Blood And Clot Thrombectomy Registry And Collaboration
NCT03153683
Condition: Acute Ischemic Stroke
Intervention: Other: Registry
Sponsors: Justin Fraser; University of Kentucky
Recruiting
Vitamin D for Muscle Metabolic Function in Cancer Cachexia
NCT03144128
Conditions: Cancer Cachexia; Vitamin D Deficiency
Interventions: Dietary Supplement: Vitamin D; Dietary Supplement: Placebo
Sponsor: David Travis Thomas
Recruiting
Pharmacodynamic Open-Label Trial With VXA-A1.1 Oral H1 Vaccine in Healthy Adults
NCT03121339
Condition: Seasonal Influenza Preventative Vaccine Pharmacodynamics
Interventions: Biological: VXA-A1.1 H1 Tablet Vaccine (small); Biological: VXA-A1.1 H1 Tablet Vaccine (large)
Sponsor: Vaxart
Completed
VITOM Study: A Randomized, Controlled Trial.
NCT03120689
Conditions: Pelvic Organ Prolapse; Prolapse of Vaginal Vault After Hysterectomy; Bulging of Vaginal Wall; Incontinence; Fistula
Interventions: Other: Live Surgery using VITOM; Other: Live Surgery without VITOM; Other: Video viewing with VITOM; Other: Video viewing with standard handheld high-definition camera
Sponsors: University of Louisville; KARL STORZ Endoscopy-America, Inc.
Completed
Assessing the Utility of Cognitive Behavioral Therapy for Pain Control in Patients With Chronic Pancreatitis
NCT03112759
Condition: Chronic Pancreatitis
Intervention: Behavioral: Cognitive Behavioral Therapy
Sponsor: University of Louisville
Unknown status
Apolipoprotein E (ApoE) and Metabolism
NCT03109561
Conditions: Cognitive Function; Healthy
Interventions: Other: Resting State Indirect Calorimetry; Genetic: ApoE; Diagnostic Test: Metabolism; Other: Cognitive Challenge
Sponsor: Lance Johnson
Recruiting
The Effect of Aromatherapy on Neonatal Abstinence Syndrome and Salivary Cortisol Levels
NCT03097484
Conditions: Neonatal Abstinence Syndrome; Aromatherapy
Intervention: Drug: lavender and chamomile essential oils
Sponsor: John M. Daniel
Completed
The INFUSE Trial - Intervening With Platelet Transfusions in Sepsis
NCT03090919
Conditions: Sepsis; Thrombocytopenia
Interventions: Biological: Platelet transfusion; Other: Saline
Sponsor: University of Kentucky
Recruiting
Evaluating Genomic Testing in Human Cancer & Outcomes of Targeted Therapies
NCT03089554
Condition: Cancer
Intervention: Drug: Therapeutic Intervention
Sponsor: Rachel Miller
Recruiting
A Study of Cisplatin or Carboplatin With Gemcitabine Versus Gemcitabine Alone as Adjuvant Therapy in Patients With Resected or Ablation Intra-Hepatic Cholangiocarcinoma
NCT03081039
Condition: Intrahepatic Cholangiocarcinoma
Interventions: Drug: Carboplatin; Drug: Cisplatin; Drug: Gemcitabine
Sponsor: University of Louisville
Withdrawn
Immunotherapy and Irreversible Electroporation in the Treatment of Advanced Pancreatic Adenocarcinoma
NCT03080974
Condition: Pancreatic Adenocarcinoma
Interventions: Drug: Nivolumab; Procedure: Irreversible Electroporation
Sponsor: University of Louisville
Recruiting
Video-Laryngoscope Alone or With Bronchoscope for Predicted Difficult Intubation
NCT03080896
Condition: Intubation; Difficult
Interventions: Device: King Vision video-laryngoscope with #3 disposable blade and endotracheal tube stylet; Device: fiberoptic bronchoscope aScope III
Sponsors: University of Louisville; Ambu A/S
Recruiting
Real World Data on Management of Male LUTS
NCT03075449
Condition: Benign Prostatic Hyperplasia
Intervention:
Sponsor: Boehringer Ingelheim
Completed
Rural Intervention for Caregivers' Heart Health
NCT03068390
Condition: Cardiovascular Risk Factor
Interventions: Behavioral: RICHH Intervention; Behavioral: Usual care
Sponsors: Debra Moser; National Institute of Nursing Research (NINR)
Recruiting
AT-001 for Long-term Preservation of Brain Health in Aging
NCT03062384
Condition: Oxidative Stress
Interventions: Dietary Supplement: AT-001; Dietary Supplement: Placebo
Sponsors: University of Kentucky; Alltech Life Sciences Inc.
Completed
Brain Exercises for Synaptic Plasticity
NCT03058055
Condition: Cognitive Change
Interventions: Behavioral: Placebo; Behavioral: Origami; Behavioral: Reading
Sponsor: University of Kentucky
Completed
Combining Opioid Addiction Treatment Services With CARe for Infectious Endocarditis
NCT03048643
Conditions: Endocarditis, Bacterial; Opioid-use Disorder; Buprenorphine; Outpatient Parenteral Antibiotic Therapy
Intervention: Behavioral: Outpatient parenteral antibiotic therapy
Sponsor: Laura Fanucchi
Completed
Stem Cell Heart Injections During Laser Revascularization Surgery for Treatment of Chronic Ischemic Heart Disease
NCT03043742
Condition: Chronic Ischemic Heart Disease
Intervention: Drug: Bone Marrow Derived Autologous CD133+ Selected Cell Product
Sponsor: Michael Sekela
Recruiting
Cangrelor in ST-Elevation Myocardial Infarction to Decrease Infarct Size
NCT03043274
Condition: STEMI - ST Elevation Myocardial Infarction
Intervention: Drug: Cangrelor
Sponsor: George Bennet, MD
Recruiting
Recovery of Bladder and Sexual Function After Spinal Cord Injury
NCT03036527
Condition: Spinal Cord Injuries
Interventions: Procedure: Activity-based locomotor training; Procedure: Activity-based stand training; Procedure: Activity-based upper arm ergometry
Sponsor: University of Louisville
Recruiting
Two Radiation Dose Schedules of SBRT to Lung Metastases < 5cm in Dimension
NCT03029416
Conditions: Neoplasm Metastasis; Cancer; Radiation Therapy Complication
Intervention: Radiation: Stereotactic Body Radiation Therapy
Sponsor: Ronald McGarry
Withdrawn
Biological Effects of Agent on PAR-4 Levels With Resected Solid Tumors
NCT03015324
Condition: Solid Tumor
Intervention: Drug: Hydroxychloroquine
Sponsor: Peng Wang, MD PhD
Recruiting
Fosbretabulin With Everolimus in Neuroendocrine Tumors With Progression
NCT03014297
Conditions: Neuroendocrine Tumors; Everolimus
Interventions: Drug: everolimus; Drug: fosbretabulin
Sponsor: Lowell Anthony, MD
Terminated
The Acute Cardiovascular Effects of Nicotine in E-cigarettes (ACE) Study
NCT03010995
Conditions: Cigarette Smoking Toxicity; Nicotine; Acute Cardiovascular Disease
Intervention: Drug: Prazosin
Sponsor: University of Louisville
Withdrawn
Impact of an Intensive Monitoring Strategy in Symptomatic Patients With Suspected Arrhythmia
NCT03001765
Condition: Suspected Arrhythmia
Intervention: Other: Intensive Monitoring Strategy: Reveal LINQ™ Insertable Cardiac Monitoring System".
Sponsor: St Elizabeth Healthcare
Completed
Use of Apremilast in Patients Who Are Dissatisfied With Stable Maintenance Topical Therapy
NCT03000309
Condition: Plaque Psoriasis
Intervention: Drug: Apremilast
Sponsors: Derm Research, PLLC; Celgene
Completed
Cisplatin + Radiation in SCCHN and Correlation With Oxidative Stress Markers
NCT02994069
Conditions: Carcinoma, Squamous Cell; Head and Neck Cancer
Interventions: Drug: Cisplatin; Radiation: XRT
Sponsor: Susanne Arnold
Recruiting
A-dmDT390-bisFv(UCHT1) Fusion Protein With Ionizing Radiation and Pembrolizumab for the Treatment of Stage IV Melanoma
NCT02990416
Condition: Stage IV Melanoma
Interventions: Biological: A-dmDT390-bisFv(UCHT1); Biological: Pembrolizumab; Radiation: Ionizing Radiation
Sponsors: Angimmune LLC; James Graham Brown Cancer Center
Unknown status
TVB 2640 for Resectable Colon Cancer Other Resectable Cancers; a Window Trial.
NCT02980029
Condition: Colon Cancer
Interventions: Drug: TVB-2640; Other: Placebo
Sponsor: Mark Evers
Recruiting
Comparison of Albuterol for Status Asthmaticus
NCT02966184
Condition: Status Asthmaticus
Intervention: Drug: preservative free albuterol
Sponsor: Norton Healthcare
Suspended
Dietary Sources of Lysophospholipids
NCT02952638
Conditions: Obesity; Cardiovascular Risk Factor; Hyperlipidemia
Intervention:
Sponsor: University of Kentucky
Recruiting
Expressions of TRPV1 in Airway of Asthmatics
NCT02952066
Conditions: Moderate Persistent Asthma; Severe Persistent Asthma; Nodule Solitary Pulmonary; Pulmonary Atelectasis
Intervention: Procedure: Bronchial biopsy
Sponsor: Lu Yuan Lee
Active, not recruiting
IL-1RA Treatment in Patients With Acute ACL Tear and Painful Effusions
NCT02930122
Condition: Anterior Cruciate Ligament Tear
Interventions: Drug: Saline (0.9%) and anakinra (150mg); Drug: anakinra (150mg) and Saline (0.9%); Other: Saline intraarticularly
Sponsors: Cale Jacobs, PhD; Arthritis Foundation
Recruiting
Electronic Decision Support for Intervention in Poorly Controlled Type 2 Diabetes
NCT02924207
Condition: Diabetes Mellitus
Intervention: Other: PATH electronic decision support tool
Sponsors: St Elizabeth Healthcare; PATH Decision Support Software, LLC
Completed
Brown Fat Activation Study
NCT02919176
Conditions: Obese; Metabolic Syndrome
Interventions: Drug: Mirabegron; Drug: Pioglitazone; Drug: Mirabegron and Pioglitazone
Sponsors: Philip Kern; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting
Magnesium And Verapamil After Recanalization in Ischemia of the Cerebrum: a Clinical and Translational Study.
NCT02912663
Condition: Ischemic Stroke
Interventions: Drug: Verapamil and Magnesium Sulfate; Other: Placebo
Sponsor: Justin Fraser
Recruiting
Vaginal and Urinary Microbiome Trial
NCT02869165
Conditions: Atrophic Vaginitis; Menopause; Recurrent Urinary Tract Infections
Interventions: Drug: Premarin vaginal cream; Drug: Apricot kernel oil
Sponsor: University of Louisville
Unknown status
Responsible Fatherhood Opportunities for Reentry & Mobility
NCT02860988
Condition: Substance Use Disorders
Intervention: Behavioral: MCCC treatment
Sponsors: Mountain Comprehensive Care Center; University of Kentucky
Recruiting
Hodgkin Lymphoma Molecular Profiling and Clinical Outcomes in U.S. Community Oncology Practices
NCT02856646
Condition: Hodgkin's Disease
Intervention:
Sponsor: Bristol-Myers Squibb
Recruiting
The INCREASE Study - Delaying the Onset of Alzheimer's Symptomatic Expression
NCT02849639
Conditions: Alzheimer's Disease; Dementia
Interventions: Other: Placebo; Other: Medication Therapy Management (MTM); Drug: Scopolamine patch
Sponsors: Daniela Moga; National Institute on Aging (NIA)
Recruiting
The Effects of Spinal Manipulation on Central Nervous System Activity Measured by Reflexive Calf Muscle Recruitment
NCT02848456
Condition: Subluxation of Joint of Lumbar Spine
Interventions: Procedure: Spinal Manipulation; Procedure: Max Voluntary Isometric Contraction; Procedure: SM+MVIC
Sponsors: Grant Sanders; University of Kentucky
Completed
Preoperative Nutrition With Immune Enhancing Nutritional Supplement (Immunomodulation)
NCT02838966
Condition: Pancreatic Adenocarcinoma
Interventions: Dietary Supplement: Nestle IMPACT Advanced Recovery; Dietary Supplement: Nestle Boost High Protein Drink
Sponsors: University of Louisville; Nestlé
Unknown status
Intermittent Hypoxemia and Acute Kidney Injury Study (IHAKI Study)
NCT02837276
Conditions: Intermittent Hypoxemia; Acute Kidney Injury; Preterm Infant
Intervention:
Sponsors: Elie G. Abu Jawdeh, MD; University of Kentucky
Completed
Superselective Citicoline and Verapamil for Ischemic Neuroprotection and Greater Effective Response
NCT02823106
Condition: Ischemic Stroke
Interventions: Drug: Verapamil and Citicoline; Other: Placebo
Sponsor: Justin Fraser
Withdrawn
Root Coverage Comparing an Allograft to a Bovine Xenograft
NCT02810067
Condition: Gingival Recession
Interventions: Procedure: Tunnel + AlloDerm; Procedure: Tunnel + Novomatrix
Sponsor: University of Louisville
Withdrawn
Ridge Preservation Comparing the Healing With or Without a Barrier Membrane
NCT02798887
Condition: Jaw, Edentulous, Partially
Intervention: Procedure: Ridge preservation
Sponsor: University of Louisville
Not yet recruiting
Shopping Smart - Adolescent Intervention to Improve Shopping Practices Where You Live and Learn
NCT02793024
Condition: Food Choices
Intervention: Behavioral: Intervention
Sponsors: Alison Gustafson; East Carolina University
Completed
Outcomes of Renal Function in Hepatorenal Syndrome (HRS) Determined By Comparison of Target Mean Arterial Pressure (MAP) of 65 - 70 Mmhg Versus ≥ 85 Mmhg
NCT02789150
Condition: Hepatorenal Syndrome
Intervention: Drug: Norepinephrine (Levophed)
Sponsor: University of Louisville
Completed
Diagnostic Value of Passive Leg Raise Induced Changes in Carotid Artery Flow Time to Predict Fluid Responsiveness in Critically Ill Patients
NCT02789124
Conditions: Fluid Responsiveness; Carotid Artery Flow Time; Passive Leg Raise
Intervention: Other: Carotid Doppler Measurement in response to passive leg raise
Sponsor: University of Louisville
Completed
ConnectEd: A Randomized Controlled Trial Connecting Through Educational Training
NCT02786472
Condition: Sexual Violence
Interventions: Behavioral: Online Bystander Training; Behavioral: Online Substance Abuse Training; Behavioral: In-Person Bystander Training; Behavioral: In-Person Combination Training
Sponsors: Heather Bush; Centers for Disease Control and Prevention
Active, not recruiting
PAV vs Assist Control After Failed SBT
NCT02773433
Condition: Weaning Mode Comparison
Intervention: Other: Proportional Assist Ventilation
Sponsor: University of Louisville
Completed
The Association of SAA With Apolipoprotein B Affects Cardiovascular Risk
NCT02770872
Condition: Cardiovascular Disease
Intervention: Other: Observation of SAA on apoB containing lipoproteins
Sponsors: Lisa Tannock; VA Office of Research and Development
Completed
Bracing Compliance and Personality Traits: A Compliance Assessment Program for Scoliosis and Clubfeet
NCT02755766
Conditions: Clubfeet; Adolescent Idiopathic Scoliosis
Intervention:
Sponsor: Shriners Hospitals for Children
Active, not recruiting
Comparison of One-port and Two-port Tissue Expanders for Breast Reconstruction
NCT02725801
Condition: Breast Cancer
Interventions: Device: Allergen one-port tissue expander placement; Device: AlloX2 two-port tissue expander placement
Sponsor: Lesley Wong
Recruiting

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