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Kentucky

• The Prevalence of White Spot Lesions During Orthodontic Treatment With Fixed Appliances

  NCT04186065

  Condition:   Dental Caries
  Intervention:  
  Sponsor:   Hiroko Nagaoka
  Enrolling by invitation
• Personalized Treatment

  NCT04183894

  Conditions:   Eating Disorders;   Eating Disorder Symptom
  Intervention:   Behavioral: Personalized Intervention
  Sponsor:   University of Louisville
  Recruiting
• Conquering Feared Foods Study

  NCT04155788

  Conditions:   Eating Disorder Symptom;   Fear
  Intervention:   Behavioral: Food Exposure
  Sponsor:   University of Louisville
  Recruiting
• Kentucky Communities and Researchers Engaging to Halt the Opioid Epidemic (CARE2HOPE)

  NCT04134767

  Conditions:   Substance Use;   HIV Infections;   HCV Infection;   Sexually Transmitted Infections (Not HIV or Hepatitis);   Overdose, Drug;   Opioid Use
  Interventions:   Behavioral: Re-entry Health Linkage;   Behavioral: Overdose Education
  Sponsors:   University of Kentucky;   National Institute on Drug Abuse (NIDA);   Substance Abuse and Mental Health Services Administration (SAMHSA);   Emory University;   Temple University
  Not yet recruiting
• Diagnosis of ON With or Without MS or NMOSD

  NCT04131764

  Conditions:   Multiple Sclerosis;   Neuromyelitis Optica Spectrum Disorder Attack;   Neuromyelitis Optica Spectrum Disorder Relapse;   Neuromyelitis Optica Spectrum Disorder Progression;   Optic Neuritis
  Intervention:   Diagnostic Test: Reflex (Brightlamp Inc., Purdue University)
  Sponsor:   University of Kentucky
  Enrolling by invitation
• MS and NMOSD in African-Americans

  NCT04131673

  Conditions:   Multiple Sclerosis;   Neuromyelitis Optica
  Intervention:  
  Sponsor:   University of Kentucky
  Enrolling by invitation
• Standing, Stepping and Voluntary Movement Spinal Cord Epidural Stimulation

  NCT04123847

  Condition:   Spinal Cord Injuries
  Interventions:   Other: Standing and Stepping;   Device: Standing, Stepping and Voluntary Movement with spinal cord Epidural Stimulation
  Sponsors:   Susan Harkema;   The Leona M. and Harry B. Helmsley Charitable Trust
  Recruiting
• Internet Auditory Rehabilitation: Follow-up to Adult Hearing Screening

  NCT04122183

  Condition:   Hearing Loss
  Intervention:   Other: iManage (my hearing loss)
  Sponsors:   University of Louisville;   William Demant Foundation (Formerly known as the Oticon Foundation)
  Not yet recruiting
• Gastric Electrical Stimulation for Abdominal Pain in Gastroparesis

  NCT04121325

  Condition:   Abdominal Pain
  Intervention:   Device: Enterra
  Sponsor:   University of Louisville
  Not yet recruiting
• Intra-operative Fraction of Inspired Oxygen and Lung Injury in Coronary Artery Bypass Grafting Surgery

  NCT04115501

  Conditions:   Lung Injury;   Pulmonary Complication
  Intervention:   Other: Fraction of Inspired Oxygen
  Sponsors:   University of Louisville;   Peking Union Medical College Hospital;   Tianjin Chest Hospital;   Xiangya Hospital of Central South University;   Guangdong Provincial People's Hospital;   Second Xiangya Hospital of Central South University;   Peking University People's Hospital
  Not yet recruiting
• Transformation of Paralysis to Stepping

  NCT04105114

  Condition:   Spinal Cord Injuries
  Interventions:   Drug: Buspirone;   Device: Non-invasive Spinal Cord Stimulation;   Device: Ekso Bionics Exoskeleton;   Device: Gravity Neutral Device;   Device: Body Weight Supported Treadmill Training;   Device: Rolling Walker
  Sponsor:   University of Louisville
  Not yet recruiting
• Timed Exercise Study

  NCT04097886

  Condition:   Circadian Timing - Exercise
  Interventions:   Other: Morning Exercise;   Other: Evening Exercise
  Sponsor:   Julie Pendergast
  Completed
• Xoft® Intraoperative Radiotherapy (IORT) for Patients With Early-Stage Breast Cancer

  NCT04088435

  Conditions:   Breast Cancer;   Breast Cancer, Invasive Ductal;   Invasive Mammary Carcinoma;   Breast Cancer Stage I;   Breast Cancer Stage IIA
  Intervention:   Radiation: Intraoperative radiotherapy
  Sponsor:   University of Louisville
  Recruiting
• Trial of Neurostimulation and Blood Flow Restriction for PFPS in Active Duty

  NCT04086615

  Condition:   Patellofemoral Pain Syndrome
  Interventions:   Device: NMES and exercise supplemented with high BFR;   Device: NMES and exercise supplemented with low BFR
  Sponsors:   University of Tennessee;   Blanchfield Army Community Hospital
  Not yet recruiting
• Neuromodulation of Spinal Locomotor Circuitry to Elicit Stepping After Pediatric Spinal Cord Injury

  NCT04077346

  Condition:   Spinal Cord Injuries
  Interventions:   Device: Biostim-5 transcutaneous spinal stimulator;   Other: Activity Based Locomotor Training;   Other: Transcutaneous Spinal Stimulator + Activity Based Locomotor Training
  Sponsor:   University of Louisville
  Not yet recruiting
• Sodium Watchers Program - Hypertension

  NCT04076280

  Condition:   Hypertension
  Interventions:   Behavioral: Sodium Watcher Program-Hypertension;   Behavioral: Usual Care
  Sponsor:   Misook L. Chung
  Recruiting
• A (Prospective/Pilot) Study Evaluating the Effect of Cataract Surgery on the Daily Activity Levels of Elderly Patients

  NCT04074954

  Conditions:   Cataract;   Diabetes;   Hypertension;   Obesity;   Vision Disability
  Intervention:   Procedure: Cataract surgery
  Sponsor:   University of Pikeville
  Recruiting
• Redefining Survivorship: POWER to Maximize Physical Function for Survivors of Critical Illness

  NCT04058977

  Conditions:   Critical Illness;   Muscle Atrophy or Weakness
  Intervention:   Other: Power training
  Sponsors:   University of Kentucky;   Nathan Johnson, PT, PhD;   Ashley Montgomery-Yates, MD;   Amy Pastva, PT, PhD;   Peter E. Morris, MD
  Not yet recruiting
• Study of Intraoperative Radiotherapy for Patients With Large Brain Metastases Treated With Neurosurgical Resection

  NCT04040400

  Condition:   Brain Metastases
  Intervention:   Device: intraoperative radiotherapy (IORT)
  Sponsor:   University of Louisville
  Recruiting
• Transcutaneous Spinal Stimulation: Safety and Feasibility for Upper Limb Function in Children With Spinal Cord Injury

  NCT04032990

  Condition:   Spinal Cord Injuries
  Intervention:   Device: Biostim-5 transcutaneous spinal stimulator
  Sponsors:   University of Louisville;   The Jewish Heritage Foundation for Excellence
  Not yet recruiting
• A Study to Evaluate the Safety and Effectiveness Assessments of Restylane-Defyne for Punctual Occlusion

  NCT04022382

  Condition:   Dry Eye
  Intervention:   Device: Restylane Defyne
  Sponsor:   John C Meyer, MD
  Completed
• Total Knee Replacement With Tourniquet or Aquamantys

  NCT04016285

  Condition:   Knee Replacement
  Interventions:   Device: Aquamantys;   Device: Tourniquet
  Sponsors:   Stephen Duncan;   Medtronic
  Recruiting
• Adrenergic Cholinergic Enteric Measures/Mapping

  NCT04013282

  Condition:   Obesity
  Intervention:  
  Sponsor:   University of Louisville
  Recruiting
• Hydroxychloroquine to Increase Tumor Suppressor PAR-4 Levels in Oligometastatic Prostate Cancer

  NCT04011410

  Condition:   Prostate Cancer Recurrent
  Intervention:   Drug: Hydroxychloroquine Sulfate 200Mg Tab
  Sponsor:   University of Kentucky
  Not yet recruiting
• Testing a Smart Phone App to Enhance Voice Therapy Adherence

  NCT04002336

  Condition:   Voice Disorders
  Interventions:   Behavioral: Traditional Voice therapy;   Behavioral: Voice Therapy App
  Sponsor:   Vrushali Angadi
  Completed
• Effects of 5HTP and LDOPA on CNS Excitability After SCI

  NCT04000919

  Condition:   Spinal Cord Injuries
  Interventions:   Drug: 5HTP;   Drug: L-DOPA;   Drug: Placebo oral tablet;   Drug: Carbidopa
  Sponsor:   Jessica M D'Amico
  Recruiting
• Non-Invasive Spinal Cord Stimulation After Injury

  NCT03998527

  Condition:   Spinal Cord Injuries
  Intervention:   Device: Transcutaneous Electrical Spinal Cord Stimulation (TcESCS)
  Sponsor:   University of Louisville
  Recruiting
• Study of Lumbar Discectomy With Annular Closure

  NCT03986580

  Condition:   Lumbar Disc Herniation
  Intervention:   Device: BARRICAID device
  Sponsor:   Intrinsic Therapeutics
  Not yet recruiting
• Study of Regional Cerebral Oxygenation and Brain Blood Volume Changes During Carotid Endarterectomy Using the NeurOS System

  NCT03981757

  Condition:   Carotid Disease
  Intervention:   Device: NeurOS
  Sponsor:   University of Louisville
  Recruiting
• Transcutaneous Spinal Stimulation: Safety and Feasibility for Trunk Control in Children With Spinal Cord Injury

  NCT03975634

  Condition:   Spinal Cord Injuries
  Intervention:   Device: Transcutaneous Spinal Stimulation
  Sponsors:   University of Louisville;   National Center of Neuromodulation for Rehabilitation (NM4R)
  Recruiting
• Regional Cerebral Oxygenation and Brain Blood Volume During Cardiac Surgery Using the NeurOS System

  NCT03969836

  Condition:   Heart Diseases
  Intervention:   Device: NeurOS system
  Sponsor:   University of Louisville
  Recruiting
• Neurobehavioral Mechanisms of Choice in Opioid Use Disorder

  NCT03958474

  Condition:   Opioid Use Disorder
  Intervention:   Drug: Oxycodone
  Sponsor:   Joshua A. Lile, Ph.D.
  Recruiting
• Combination Rucaparib With Nivolumab in Small Cell Lung Carcinoma

  NCT03958045

  Condition:   Small Cell Lung Cancer
  Intervention:   Combination Product: Rucaparib and Nivolumab
  Sponsor:   Aman Chauhan
  Recruiting
• Behavioral Effects of Drugs (Inpatient): 38

  NCT03954938

  Condition:   Cocaine Use, Unspecified
  Interventions:   Behavioral: Craving Manipulation;   Drug: Cocaine;   Drug: Placebo
  Sponsor:   William Stoops
  Recruiting
• Improving Hand Recovery With Neuromodulation in Tetraplegia

  NCT03954496

  Conditions:   Spinal Cord Injuries;   Tetraplegia, Unspecified, Incomplete, Chronic
  Interventions:   Device: transcranial direct current stimulation;   Behavioral: Intensive upper extremity motor training
  Sponsors:   University of Kentucky;   Wings for Life - spinal cord research foundation
  Recruiting
• Better Together: A Web-based Relationship Education Tool

  NCT03953495

  Condition:   Same-Sex Relationships
  Interventions:   Behavioral: Better Together;   Behavioral: Better Together (delayed)
  Sponsor:   Sharon Scales Rostosky
  Recruiting
• The Kentucky Viral Hepatitis Treatment Study

  NCT03949764

  Conditions:   Hepatitis C;   Opioid-Related Disorders;   Injection Drug Use
  Intervention:   Drug: Sofosbuvir/velpatasvir (Epclusa®)
  Sponsors:   Jennifer Havens;   National Institute on Drug Abuse (NIDA);   National Cancer Institute (NCI);   Gilead Sciences;   University of Kentucky;   Icahn School of Medicine at Mount Sinai;   University of Bristol
  Not yet recruiting
• Neural Mechanisms of Cannabinoid-impaired Decision-Making in Emerging Adults

  NCT03944954

  Conditions:   Neurosciences;   Substance-Related Disorders;   Behavior Problem
  Interventions:   Drug: Marinol;   Device: Transcranial Magnetic Stimulation
  Sponsor:   University of Kentucky
  Recruiting
• Tourniquet vs. Short Time Tourniquet in Primary Robotic Assisted TKA

  NCT03942939

  Condition:   Knee Arthropathy
  Interventions:   Other: Primary Robotic-Assisted Total Knee Arthroplasty with a short tourniquet time;   Other: Primary Robotic-Assisted Total Knee Arthroplasty with the use of a tourniquet
  Sponsor:   University of Louisville
  Recruiting
• Fetal Life: Smart-Device Based Uterine Activity Monitoring

  NCT03940365

  Conditions:   Labor Pain;   Contraction
  Intervention:   Device: Fetal Life tocometer device
  Sponsors:   Fetal Life LLC;   University of Louisville
  Not yet recruiting
• Suvorexant and Cocaine

  NCT03937986

  Condition:   Cocaine Use Disorder
  Interventions:   Drug: Suvorexant;   Drug: Cocaine;   Drug: Placebo oral capsule
  Sponsors:   William Stoops;   National Institute on Drug Abuse (NIDA)
  Recruiting
• Imaginal Exposure II Study: In-Vivo

  NCT03934697

  Conditions:   Eating Disorder;   Anorexia Nervosa;   Bulimia Nervosa;   Exposure
  Intervention:   Behavioral: imaginal exposure therapy
  Sponsor:   University of Louisville
  Recruiting
• Gentamicin Bladder Instillation in Individuals With Spinal Cord Injury Having Chronic Urinary Tract Infections

  NCT03931408

  Conditions:   Neurogenic Bladder;   Spinal Cord Injuries
  Interventions:   Drug: Gentamicin Sulfate;   Other: Placebo instillation (saline alone);   Other: No instillation
  Sponsor:   University of Louisville
  Recruiting
• DUR-928 in Patients With Alcoholic Hepatitis

  NCT03917407

  Condition:   Alcoholic Hepatitis
  Interventions:   Drug: DUR-928 (Moderate AH);   Drug: DUR-928 (Severe AH)
  Sponsors:   Craig James McClain;   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
  Not yet recruiting
• Durvalumab and Tremelimumab Combination in Somatically Hypermutated Recurrent Solid Tumors

  NCT03911557

  Condition:   Tumor, Solid
  Intervention:   Drug: Durvalumab and Tremelimumab
  Sponsor:   John L. Villano, MD, PhD
  Recruiting
• Role of ASpirin in Placental and Maternal Endothelial Cell Regulation IN Pre-eclampsia

  NCT03893630

  Condition:   Pre-Eclampsia
  Interventions:   Drug: Acetylsalicylic Acid 81 mg;   Drug: Acetylsalicylic Acid 162 mg;   Other: Control
  Sponsor:   John O'Brien, MD
  Recruiting
• Intramedullary Bone Grafting for Open Tibial Shaft Fractures

  NCT03891888

  Conditions:   Tibial Fractures;   Nonunion of Fracture;   Delayed Union of Fracture
  Intervention:   Procedure: Intramedullary Bone Graft
  Sponsor:   University of Louisville
  Not yet recruiting
• Valproic Acid and Dihydroergotamine as Abortive Therapy in Pediatric Migraine

  NCT03885154

  Condition:   Migraine in Children
  Interventions:   Drug: Valproic Acid (VPA);   Drug: Dihydroergotamine (DHE)
  Sponsor:   Kimberly S Jones
  Recruiting
• Prospective, Multi-center Study to Assess Posterolateral Fusion Using FIBERGRAFT

  NCT03884283

  Conditions:   Degenerative Disc Disease;   Spondylolisthesis;   Spinal Stenosis Lumbar
  Intervention:   Device: FIBERGRAFT BG Matrix
  Sponsor:   Prosidyan, Inc.
  Enrolling by invitation
• Gastroparesis Outcome Longitudinal Database Enrolled Numerically

  NCT03876288

  Condition:   Gastroparesis
  Interventions:   Device: GI Neuromodulation;   Drug: Immunotherapy;   Procedure: Pyloric Therapies
  Sponsor:   University of Louisville
  Recruiting
• Assessment of Gut Absorption of Experimental Medication BMS-986165 in Healthy Males

  NCT03873415

  Condition:   Psoriasis
  Intervention:   Drug: BMS-986165
  Sponsor:   Bristol-Myers Squibb
  Completed
• Clinical Trial on the Preventive Effect of Intravaginal Prasterone on Recurrent Urinary Tract Infections in Postmenopausal Women

  NCT03854396

  Conditions:   Recurrent Urinary Tract Infection;   Postmenopause;   Postmenopausal Syndrome;   Postmenopausal Symptoms;   Menopause
  Interventions:   Drug: Prasterone;   Drug: Placebo
  Sponsors:   Olivia Cardenas-Trowers, M.D.;   AMAG Pharmaceuticals, Inc.
  Not yet recruiting
• The Effect of Enstilar Versus Vehicle on Target Lesions in Moderate Plaque Type Psoriasis Patients

  NCT03848871

  Condition:   Plaque Psoriasis
  Intervention:   Drug: Enstilar
  Sponsor:   Derm Research, PLLC
  Completed
• Intraoral Administration of Botox in Patients With Dentoalveolar Neuropathic Pain

  NCT03848143

  Condition:   Neuropathic Pain
  Intervention:   Drug: onabotulinum toxin A
  Sponsors:   Isabel Moreno Hay;   Allergan Sales, LLC
  Recruiting
• ACB + IPACK Block With or Without Local Infiltration in RA-TKA

  NCT03840122

  Condition:   Knee Arthropathy
  Interventions:   Other: ACB + IPACK block with injection of local anesthetic;   Other: ACB + IPACK block without injection
  Sponsor:   University of Louisville
  Withdrawn
• Dietary Intervention in Persons With Metabolic Syndrome

  NCT03836651

  Condition:   Metabolic Syndrome
  Interventions:   Other: Dietary Antioxidant (V8® Low Sodium 100% vegetable juice);   Other: Control group
  Sponsor:   Martha Biddle
  Recruiting
• Oral Health Promotion Strategy for Persons With Intellectual/Developmental Disabilities

  NCT03834064

  Condition:   Oral Health
  Intervention:   Behavioral: Oral health promotion strategy
  Sponsors:   University of Louisville;   National Institute of Dental and Craniofacial Research (NIDCR)
  Enrolling by invitation
• Transvaginal Ultrasound: Preterm Birth in Appalachia

  NCT03833284

  Condition:   Preterm Birth
  Interventions:   Behavioral: Participant Barriers to TVU Screening;   Behavioral: Provider Barriers to TVU Screening
  Sponsor:   Niraj Chavan
  Recruiting
• Behavioral and Enhanced Perinatal Intervention for Cessation (B-EPIC): Reducing Tobacco Use Among Opioid Addicted Women

  NCT03796208

  Condition:   Smoking Cessation
  Interventions:   Behavioral: Behavioral and Enhanced Perinatal Intervention for Cessation (B-EPIC);   Behavioral: Treatment As Usual
  Sponsors:   Kristin Ashford;   National Institute on Drug Abuse (NIDA)
  Recruiting
• Antidepressant Discontinuation in Treatment Resistant Depression

  NCT03786614

  Condition:   Treatment Resistant Depression
  Interventions:   Other: Discontinuation of serotonergic antidepressants;   Other: Continuation of serotonergic medications
  Sponsor:   University of Louisville
  Not yet recruiting
• Impact of SPEAC® System Data on Therapeutic Decisions Related to Convulsive Seizure Patients With a New Diagnosis

  NCT03742661

  Condition:   Epilepsy
  Intervention:   Device: SPEAC System
  Sponsor:   Brain Sentinel
  Active, not recruiting
• Pentamidine + Salvage Chemo for Relapsed/Refractory Classical Hodgkin Lymphoma

  NCT03730363

  Conditions:   Hodgkin Lymphoma;   Refractory Hodgkin Lymphoma
  Intervention:   Drug: Pentamidine
  Sponsor:   University of Kentucky
  Recruiting
• HO Prophylaxis Therapy for Distal Humerus Fractures

  NCT03724422

  Conditions:   Heterotopic Ossification;   Humeral Fractures;   Radiation Therapy
  Intervention:   Radiation: Radiation
  Sponsor:   University of Louisville
  Not yet recruiting
• Evaluating an Amino Acid Based Medical Food w/ Diarrhea in Carcinoid Syndrome & Other NETs

  NCT03722511

  Conditions:   Neuroendocrine Tumors;   Carcinoid Tumor of GI System;   Diarrhea;   Carcinoid Syndrome
  Intervention:   Dietary Supplement: Amino Acid Based Medical Food/Drink
  Sponsors:   University of Kentucky;   Entrinsic Health Solutions, Inc.
  Recruiting
• Muscle Dysfunction in Critical Illness

  NCT03717831

  Conditions:   Critical Illness;   Intensive Care (ICU) Myopathy;   PICS;   Muscle Weakness
  Intervention:  
  Sponsor:   University of Kentucky
  Recruiting
• Online Imaginal Exposure

  NCT03712748

  Conditions:   Eating Disorder;   Exposure;   Anorexia Nervosa;   Bulimia Nervosa;   Binge-Eating Disorder;   Therapy
  Intervention:   Behavioral: Imaginal Exposure therapy
  Sponsor:   University of Louisville
  Recruiting
• A Study to Evaluate the Safety and Effectiveness of Restylane-Defyne for Punctual Occlusion

  NCT03709641

  Condition:   Mild to Moderate Dry Eye Disease
  Intervention:   Device: Restylane Defyne
  Sponsor:   John C Meyer, MD
  Completed
• Treatment of FUS-Related ALS With Betamethasone - The TRANSLATE Study

  NCT03707795

  Condition:   Familial Amyotrophic Lateral Sclerosis
  Intervention:   Drug: Betamethasone sodium phosphate/betamethasone acetate (Celestone® Soluspan®), 30 mg IM once a day for four days
  Sponsor:   University of Kentucky
  Recruiting
• Opioid and Cannabinoid Interactions

  NCT03705559

  Conditions:   Marijuana Usage;   Opioid Use
  Interventions:   Drug: Vaporized Marijuana;   Drug: Opioid Agonist
  Sponsor:   Shanna Babalonis, PhD
  Recruiting
• Marijuana Effects on Simulated Driving Performance

  NCT03699540

  Conditions:   Cannabis;   Cannabis Use;   Marijuana;   Marijuana Usage;   Alcohol Drinking
  Interventions:   Drug: Marijuana;   Drug: Alcohol
  Sponsor:   Shanna Babalonis, PhD
  Recruiting
• WoundVac in Obese Patients Undergoing Lumbar Surgery

  NCT03688438

  Conditions:   Obesity;   Lumbar Spine Surgery
  Intervention:   Device: Closed-Incision Negative-Pressure Therapy
  Sponsor:   Norton Leatherman Spine Center
  Not yet recruiting
• CAMS-G Group Therapy for Suicidal Veterans

  NCT03682406

  Condition:   Suicide and Self-harm
  Intervention:   Behavioral: CAMS-G
  Sponsors:   Louisville VA Medical Center;   Rocky Mountain MIRECC for Suicide Prevention
  Recruiting
• Inflammatory Markers in Trauma Patient Outcomes

  NCT03671746

  Condition:   Polytrauma
  Interventions:   Drug: Ketorolac;   Drug: Saline Solution
  Sponsor:   Arun Aneja
  Recruiting
• Health, Environment and Action in Louisville (HEAL) Green Heart Louisville Project

  NCT03670524

  Conditions:   Cardiovascular Diseases;   Metabolic Health
  Intervention:   Other: Greenness as a therapeutic intervention
  Sponsors:   University of Louisville;   National Institute of Environmental Health Sciences (NIEHS);   The Nature Conservancy
  Recruiting
• Elbow Arthroscopy Data Analysis

  NCT03656185

  Conditions:   Osteoarthritis Elbow Left;   Osteoarthritis Elbow Right;   Lateral Epicondylitis, Left Elbow;   Lateral Epicondylitis, Right Elbow;   Plica Syndromes;   Osteochondritis Dissecans
  Intervention:  
  Sponsor:   The Orthopaedic Research & Innovation Foundation
  Active, not recruiting
• The ASTERS Study: Assessing the Role of Sphingolipids in AcuTE Respiratory Distress Syndrome (ARDS)

  NCT03654352

  Conditions:   Acute Lung Injury;   Acute Respiratory Distress Syndrome
  Intervention:  
  Sponsor:   University of Kentucky
  Recruiting
• Neuro-ocular Baselines in a Sports Setting

  NCT03653936

  Condition:   Wave Form Signals Coming From the Eye in a Healthy Cohort
  Intervention:   Device: HITT device
  Sponsors:   Rebiscan, Inc.;   BlueGrass Orthopaedics Surgery & Hand Care
  Completed
• Patient Satisfaction With Postoperative Follow up After Minimally Invasive Hysterectomy

  NCT03642743

  Conditions:   Minimally Invasive Surgery;   Hysterectomy;   Postoperative;   Satisfaction
  Intervention:   Other: postoperative follow up appointment
  Sponsor:   University of Louisville
  Recruiting
• Retrospective Analysis on Distal Humerus Fractures

  NCT03637621

  Condition:   Distal Humerus Fracture
  Intervention:   Other: ORIF
  Sponsor:   The Orthopaedic Research & Innovation Foundation
  Active, not recruiting
• Proximal Humerus Fractures: A Retrospective Analysis

  NCT03637608

  Condition:   Proximal Humeral Fracture
  Intervention:  
  Sponsor:   The Orthopaedic Research & Innovation Foundation
  Active, not recruiting
• Iron Dosing Pilot Study Using Model Predictive Control

  NCT03633656

  Conditions:   Renal Insufficiency, Chronic;   Anemia, Iron Deficiency;   Anemia of Chronic Kidney Disease
  Intervention:   Device: Model predictive control
  Sponsor:   University of Louisville
  Not yet recruiting
• Incontinence Management System ICU Field Evaluation

  NCT03628833

  Conditions:   Urinary Incontinence;   Fecal Incontinence
  Intervention:   Device: Incontinence Management System
  Sponsor:   Hill-Rom
  Completed
• Posterior Approach to Total Shoulder Arthroplasty

  NCT03623269

  Conditions:   Total Shoulder Arthroplasty;   Osteo Arthritis Shoulders
  Intervention:   Procedure: posterior approach to total shoulder arthroplasty
  Sponsor:   The Orthopaedic Research & Innovation Foundation
  Active, not recruiting
• Functional and Self-reported Outcomes in Participants With a History of Musculoskeletal Knee Injury

  NCT03617991

  Conditions:   Anterior Cruciate Ligament Injury;   Anterior Cruciate Ligament Rupture
  Intervention:   Other: Exercise Group
  Sponsor:   Johanna M. Hoch
  Recruiting
• Reverse Total Shoulder Arthroplasty: A Data Analysis on Patients Undergoing Reverse Total Shoulder Arthroplasty

  NCT03617107

  Conditions:   Osteo Arthritis Shoulders;   Proximal Humeral Fracture;   Rotator Cuff Tear;   Rotator Cuff Tear Arthropathy
  Intervention:   Other: reverse total shoulder arthroplasty
  Sponsor:   The Orthopaedic Research & Innovation Foundation
  Active, not recruiting
• Does Depth of Neuromuscular Blockade (NMB) Affect Surgical Conditions in Obese Patients Undergoing Robotic Surgery

  NCT03591289

  Conditions:   GYN Disorders;   Urologic Diseases
  Intervention:   Drug: NMB with rocuronium bromide
  Sponsor:   Rainer Lenhardt
  Recruiting
• Root Coverage With Acellular Dermal Matrix and Bovine Derived Osseous

  NCT03582995

  Condition:   Recession, Gingival
  Interventions:   Procedure: Flap Surgery for root coverage with Alloderm and xenograft;   Procedure: Tunnel Surgery for root coverage with Alloderm and xenograft
  Sponsor:   University of Louisville
  Not yet recruiting
• Community Access, Retention in Care, and Engagement for Hepatitis C Treatment

  NCT03581383

  Condition:   Hepatitis C
  Interventions:   Behavioral: PREP-C;   Behavioral: Modified ECHO
  Sponsor:   Jens Rosenau
  Recruiting
• Clinical Effects of Hard and Soft Tissue Grafting With Dental Implants

  NCT03580811

  Condition:   Dental Implants
  Interventions:   Device: Dental Implant &ADMG;   Device: Dental implant & ADMG & BDX
  Sponsor:   University of Louisville
  Not yet recruiting
• Behavioral Effects of Drugs: Inpatient (36) (Alcohol, Duloxetine, and Methylphenidate)

  NCT03575403

  Condition:   Alcohol Use Disorder
  Interventions:   Drug: Alcohol;   Drug: Placebos;   Drug: Duloxetine;   Drug: Methylphenidate
  Sponsors:   Craig Rush;   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
  Recruiting
• Building Stronger Allies

  NCT03571750

  Conditions:   Suicide;   Risk Reduction
  Interventions:   Behavioral: Building Stronger Allies;   Behavioral: Health Education Training
  Sponsor:   Florida State University
  Recruiting
• Tanglewood to Table: A Walking Farmer's Market Group and Control

  NCT03567252

  Condition:   Dietary Habits
  Intervention:   Behavioral: Walking Group
  Sponsors:   Dawn Brewer;   National Institute of Environmental Health Sciences (NIEHS)
  Completed
• A Review of Low-Dose CT Lung Cancer Screenings in a Community-Based Healthcare System With High Incidence

  NCT03560791

  Condition:   Non-small Cell Lung Cancer
  Intervention:  
  Sponsor:   St Elizabeth Healthcare
  Enrolling by invitation
• Effects of Family Sodium Watcher Program on Outcomes in Heart Failure Patient-Family Caregiver Dyads

  NCT03560206

  Condition:   Heart Failure
  Interventions:   Behavioral: Family SWaP intervention with mini iPad;   Behavioral: usual care
  Sponsor:   Misook L. Chung
  Active, not recruiting
• Increasing PrEP Among African Americans in Louisville KY

  NCT03559595

  Condition:   HIV/AIDS PREVENTION
  Intervention:   Behavioral: Project Prevent
  Sponsor:   University of Louisville
  Recruiting
• Pediatric Locomotor Training Bladder Study

  NCT03559036

  Conditions:   Spinal Cord Injuries;   Neurogenic Bladder
  Intervention:   Procedure: Locomotor Training
  Sponsors:   University of Louisville;   The Leona M. and Harry B. Helmsley Charitable Trust;   Kosair Charities, Inc.
  Recruiting
• Neural Correlates of Self-regulation on Academic Functioning

  NCT03549377

  Condition:   Self-Control
  Intervention:   Behavioral: Deception
  Sponsor:   Alexander Vazsonyi
  Completed
• An Analysis of Treatment Timelines for Lung Cancer Patients Across System Evolutions

  NCT03535766

  Condition:   Lung Cancer
  Intervention:  
  Sponsor:   St Elizabeth Healthcare
  Enrolling by invitation
• Teachable Moment Brief Intervention for Veterans Following a Suicide Attempt

  NCT03533075

  Condition:   Suicide, Attempted
  Intervention:   Behavioral: Teachable Moment Brief Intervention
  Sponsors:   Louisville VA Medical Center;   University of Louisville
  Active, not recruiting
• Idiopathic Parkinson's Progression and Dopamine Transporter SPECT

  NCT03531086

  Condition:   Parkinson Disease
  Intervention:   Drug: Ioflupane I 123
  Sponsor:   Julie Gurwell
  Active, not recruiting
• Behavioral Effects of Drugs: Inpatient (35)

  NCT03519022

  Condition:   Cocaine Use Disorder
  Interventions:   Drug: Cocaine;   Drug: Placebo oral capsule;   Drug: Methylphenidate
  Sponsors:   Craig Rush;   National Institute on Drug Abuse (NIDA)
  Completed
• The Role of Physical Activity During Pregnancy on Metabolic Function, Inflammation, and Maternal and Neonatal Outcomes

  NCT03504319

  Conditions:   Obesity;   Pregnancy Related
  Intervention:   Other: Exposure to high-fat smoothie
  Sponsor:   Western Kentucky University
  Active, not recruiting
• Evidence-based Educational Materials and Local Resources for Improving Exercise-related Outcomes During Pregnancy

  NCT03504267

  Conditions:   Pregnancy Related;   Obesity
  Intervention:   Other: Physical Activity Education and Resources
  Sponsor:   Western Kentucky University
  Completed
• Subacute Low Back Pain in Active Duty

  NCT03502187

  Condition:   Subacute Low Back Pain
  Interventions:   Behavioral: Progressive Exercise Plan;   Device: NeuromuscularElectricalStimulation(NMES);   Behavioral: Primary Care Management (PCM)
  Sponsors:   University of Tennessee;   Blanchfield Army Community Hospital
  Recruiting
• An Interactive Text-Message Based Brief Intervention to Reduce Substance-Impaired Driving Among College Students

  NCT03496129

  Condition:   Alcohol-Impaired Driving
  Interventions:   Behavioral: Personalized feedback;   Behavioral: Personalized feedback and text messages;   Behavioral: Information Only
  Sponsor:   Western Kentucky University
  Enrolling by invitation
• Tanglewood Trail Walking Program in Rural Kentucky

  NCT03495648

  Condition:   Dietary Habits
  Interventions:   Behavioral: walking group led by a community organizer;   Behavioral: Drive
  Sponsors:   Dawn Brewer;   National Institute of Environmental Health Sciences (NIEHS)
  Active, not recruiting
• Plant Exosomes and Patients Diagnosed With Polycystic Ovary Syndrome (PCOS) 17

  NCT03493984

  Condition:   Polycystic Ovary Syndrome
  Interventions:   Other: Ginger exosomes;   Other: Aloe exosomes;   Other: Placebo
  Sponsor:   University of Louisville
  Recruiting
• A 14 Weeks Longitudinal Study to Investigate the Effect of Leukocyte- Platelet Rich Fibrin Plug on the Quality of the Newly Formed Bone in Ridge Preservation Procedure Following a Tooth Extraction. It is a Clinical, Radiographic and Histomorphometric Study.

  NCT03487718

  Conditions:   Alveolar Ridge Preservation;   Tooth Extraction
  Interventions:   Biological: Leukocyte platelet rich fibrin plug + d-PTFE membrane;   Biological: d-PTFE membrane
  Sponsor:   Firas Al Yafi
  Recruiting
• Chemotherapy and Irreversible Electroporation in the Treatment of Advanced Pancreatic Adenocarcinoma

  NCT03484299

  Condition:   Pancreas Cancer
  Interventions:   Procedure: Irreversible Electroporation (IRE);   Drug: Gemcitabine;   Drug: FOLFIRINOX
  Sponsor:   University of Louisville
  Recruiting
• Adaptation and Pilot Testing of a Behavioral Parent Training Program for Parents of Deaf and Hard of Hearing Children

  NCT03483428

  Conditions:   Hearing Loss;   Behavior Disorders;   Parenting
  Interventions:   Behavioral: Interventionist training and supervision;   Behavioral: Behavioral parent training
  Sponsor:   University of Kentucky
  Completed
• BerryCare: A Community Engagement Program

  NCT03477305

  Condition:   Cardiovascular Risk Factor
  Intervention:   Behavioral: Blackberry Consumption
  Sponsors:   Dawn Brewer;   National Institute of Environmental Health Sciences (NIEHS)
  Completed
• Clinic to Community Navigation to Improve Diabetes Outcomes

  NCT03474731

  Condition:   Diabetes Mellitus
  Interventions:   Behavioral: Diabetes Self Management Program;   Behavioral: Tailored Patient Navigation (PN) only;   Behavioral: DSMP AND Tailored Patient Navigation
  Sponsor:   Nancy Schoenberg
  Recruiting
• Promoting Colorectal Cancer Screening in Rural Emergency Departments

  NCT03473587

  Condition:   Colorectal Cancer
  Interventions:   Behavioral: Motivational interview;   Behavioral: Standard of care
  Sponsor:   University of Kentucky
  Recruiting
• Clinical Trial Comparing Two Bladder Instillations for IC/BPS

  NCT03463915

  Conditions:   Interstitial Cystitis;   Bladder Pain Syndrome
  Interventions:   Drug: Bladder instillation WITH triamcinolone acetonide;   Drug: Bladder instillation WITHOUT triamcinolone acetonide
  Sponsor:   Olivia Cardenas-Trowers, M.D.
  Recruiting
• The Use of Oracea and Epiduo Forte in Severe Acne Patients

  NCT03457636

  Condition:   Acne
  Interventions:   Drug: Doxycycline Anhydrous 40 MG;   Drug: Adapalene/Benzoyl Peroxide Gel 0.3-2.5%
  Sponsor:   Derm Research, PLLC
  Completed
• Social Media HIV Prevention Intervention for High Risk Rural Women

  NCT03456453

  Condition:   HIV/AIDS
  Intervention:   Behavioral: NIDA Standard for HIV Prevention
  Sponsors:   University of Kentucky;   National Institute on Drug Abuse (NIDA)
  Recruiting
• SPARC Bladder Mapping and Training Study

  NCT03452007

  Condition:   Spinal Cord Injuries
  Intervention:   Device: Epidural Stimulation
  Sponsor:   University of Louisville
  Recruiting
• Re-entry XR-NTX for Rural Women With Opioid Use Disorder

  NCT03447743

  Condition:   Opioid Dependence
  Intervention:   Drug: XR-NTX community location
  Sponsor:   University of Kentucky
  Recruiting
• Study Investigating Role of Unalike Patient Positioning on PROMIS Scores

  NCT03446950

  Conditions:   Physical Activity;   Surgery;   Vaginal Hysterectomy;   Vaginal Surgery
  Intervention:   Procedure: Vaginal Surgery
  Sponsor:   University of Louisville
  Recruiting
• Tobacco Use in Pregnancy Intervention for Cessation

  NCT03442530

  Condition:   Pregnancy
  Interventions:   Behavioral: ToPIC;   Behavioral: Tobacco Treatment As Usual (TTAU)
  Sponsors:   Kristin Ashford;   University of Kentucky
  Active, not recruiting
• Brief Online Interventions for Alcohol Use

  NCT03438539

  Condition:   Alcohol Use Disorder
  Interventions:   Behavioral: Normative Feedback;   Behavioral: Inhibitory Control Training;   Behavioral: Working Memory Training
  Sponsors:   Craig Rush;   National Institute on Drug Abuse (NIDA)
  Recruiting
• Early Anti-inflammatory Treatment in Patients With Acute ACL Tear and Painful Effusions

  NCT03429140

  Condition:   Anterior Cruciate Ligament
  Interventions:   Drug: Gel-One;   Other: Saline Placebo
  Sponsor:   Mary Ireland
  Active, not recruiting
• Socket Preservation: A Clinical and Histological Study

  NCT03422692

  Condition:   Alveolar Ridge Augmentations
  Interventions:   Biological: BioXclude amnion-chorion membrane;   Biological: Mem-Lok collagenous membrane
  Sponsor:   University of Kentucky
  Completed
• "Assessment of the Quality and Quantity of Bone Regeneration."

  NCT03417375

  Condition:   Bone Quality and Quantity
  Intervention:   Procedure: Bilateral Sinus Augmentation
  Sponsor:   University of Kentucky
  Active, not recruiting
• To Investigate the Gastrointestinal Behaviour of Two Triple Combination Products in Healthy Male Volunteers

  NCT03415243

  Condition:   Common Cold
  Interventions:   Drug: Acetaminophen 650mg+Dextromethorphan 20mg+Phenylephrine 10mg;   Drug: Acetaminophen 325mg+Dextromethorphan 10mg+Phenylephrine 5mg
  Sponsor:   GlaxoSmithKline
  Completed
• Exercise and Weight Control

  NCT03413826

  Conditions:   Obesity;   Exercise Reinforcement
  Intervention:   Behavioral: Exercise
  Sponsor:   University of Kentucky
  Completed
• The Use of Onexton in Moderate Acne Vulgaris for Patients With Skin of Color

  NCT03402893

  Conditions:   Acne Vulgaris;   Post Inflammatory Hyperpigmentation
  Intervention:   Drug: ONEXTON Topical Gel
  Sponsor:   Derm Research, PLLC
  Completed
• Non-Opiate Treatment After Prenatal Opiate Exposure to Prevent Postnatal Injury to the Young Brain

  NCT03396588

  Condition:   Neonatal Abstinence Syndrome
  Interventions:   Drug: Clonidine;   Drug: Morphine
  Sponsors:   University of Kentucky;   National Institute on Drug Abuse (NIDA)
  Recruiting
• Thick vs. Thin Acellular Dermal Matrix (ADM)

  NCT03392038

  Condition:   Gingival Recession
  Interventions:   Procedure: Thin ADM;   Procedure: Thick ADM
  Sponsor:   University of Louisville
  Unknown status
• Telemedicine-based, Multidisciplinary-team, Intervention to Reduce Unnecessary Hospitalizations

  NCT03378245

  Conditions:   Dementia Alzheimers;   Disruptive Behavior
  Intervention:   Behavioral: Behavioral modification and education on pharmacologic treatments.
  Sponsor:   Richard Ronan Murphy
  Suspended
• Task-specific Epidural Stimulation Study

  NCT03364660

  Condition:   Spinal Cord Injuries
  Interventions:   Device: Epidural Stimulation;   Biological: Stand Training
  Sponsor:   University of Louisville
  Recruiting
• The PSVT Place Registry.Paroxysmal Supraventricular Tachycardia (PSVT) Registry.

  NCT03353610

  Condition:   Paroxysmal Supraventricular Tachycardia (PSVT)
  Intervention:  
  Sponsor:   Milestone Pharmaceuticals Inc.
  Recruiting
• Toxicity & Pharmacokinetics of 2 & 3-weekly Docetaxel in Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)

  NCT03343977

  Condition:   Metastatic Hormone-Sensitive Prostate Cancer
  Interventions:   Drug: docetaxel 50mg/m2;   Drug: docetaxel 75mg/m2
  Sponsor:   Peng Wang, MD PhD
  Withdrawn
• Chemotherapy-Induced Cognitive Impairment in Ovarian Cancer Patients

  NCT03324945

  Condition:   Chemotherapy-induced Cognitive Impairment
  Intervention:   Behavioral: Neurocognitive assessments
  Sponsors:   University of Kentucky;   Office of US Army Medical Research and Material Command
  Active, not recruiting
• Impact of Envarsus XR® on Kidney Biopsy Subclinical Rejection and Blood Immunologic Profile

  NCT03321656

  Condition:   End Stage Renal Disease
  Interventions:   Drug: Tacrolimus;   Drug: Envarsus XR
  Sponsors:   Roberto Gedaly;   Veloxis Pharmaceuticals
  Recruiting
• Consultation, Advice, and Tailored Support (CATS) for Cancer Survivors

  NCT03316170

  Conditions:   Smoking Cessation;   Social Stress
  Interventions:   Behavioral: Social Support;   Drug: NRT Sampling
  Sponsors:   Jessica Burris;   Kentucky Lung Cancer Research Program
  Recruiting
• Priming Immunotherapy in Advanced Disease With Radiation

  NCT03313804

  Conditions:   Non-small Cell Lung Cancer;   Squamous Cell Carcinoma of the Head and Neck
  Interventions:   Drug: Immune checkpoint inhibitor;   Radiation: Radiation Therapy
  Sponsor:   John L. Villano, MD, PhD
  Recruiting
• Sedative-Anxiolytic Effects on Simulated Driving Performance

  NCT03297944

  Condition:   Psychomotor Impairment
  Interventions:   Drug: Alprazolam;   Drug: Zolpidem;   Drug: Placebo
  Sponsors:   Marion Coe;   National Institute on Drug Abuse (NIDA)
  Completed
• Dysregulated CNS Inflammation After Acute Brain Injury

  NCT03287557

  Conditions:   Traumatic Brain Injury;   Aneurysmal Subarachnoid Hemorrhage
  Intervention:  
  Sponsor:   University of Kentucky
  Completed
• A Pilot Study Using Autologous Regulatory T Cell Infusion Zortress (Everolimus) in Renal Transplant Recipients

  NCT03284242

  Conditions:   End Stage Renal Disease;   Kidney Transplant
  Intervention:   Procedure: Apheresis
  Sponsors:   Roberto Gedaly;   Novartis Pharmaceuticals
  Recruiting
• Removable Partial Denture Abutments Restored With Monolithic Zirconia Crowns

  NCT03283709

  Conditions:   Crowns;   Denture
  Interventions:   Device: Full-contour monolithic zirconia abutment crowns;   Device: Conventional abutment crowns
  Sponsor:   University of Kentucky
  Recruiting
• Assessing Repeat Fit Testing for CRC

  NCT03248661

  Condition:   Colo-rectal Cancer
  Intervention:   Behavioral: Now I'm Telling You
  Sponsors:   Richard Crosby;   Centers for Disease Control and Prevention
  Completed
• Mantra Meditation in Subjects That Have Chronically Impaired Attention After Stroke

  NCT03229902

  Condition:   Stroke Sequelae
  Intervention:   Behavioral: mantra meditation
  Sponsor:   Cheryl Carrico
  Completed
• Cocaine Use Reduction and Health

  NCT03224546

  Condition:   Cocaine Use Disorder
  Intervention:   Behavioral: Contingency Management
  Sponsors:   William Stoops;   National Institute on Drug Abuse (NIDA)
  Recruiting
• Intraoperative Amiodarone to Prevent Atrial Fibrillation in Lung Transplant Patients

  NCT03221764

  Conditions:   Atrial Fibrillation;   Lung Transplant; Complications
  Interventions:   Drug: Amiodarone with CoSeal;   Device: CO2 driver
  Sponsor:   University of Louisville
  Completed
• Influence of n-Acetylcysteine Maintenance on Alcohol Effects

  NCT03216954

  Condition:   Alcohol Use Disorder
  Interventions:   Drug: Alcohol;   Drug: Placebos;   Drug: N-acetyl cysteine
  Sponsors:   William Stoops;   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
  Recruiting
• Corazon de la Familia (Heart of the Family)

  NCT03196024

  Conditions:   Risk Reduction Behavior;   Diabetes Mellitus, Type 2;   Cardiovascular Diseases
  Interventions:   Behavioral: Family-focused intervention arm;   Behavioral: Individual-focused intervention arm
  Sponsors:   University of Kentucky;   National Institute of Nursing Research (NINR);   National Institutes of Health (NIH)
  Recruiting
• Evaluation of the Efficacy and Safety of Bempedoic Acid (ETC-1002) 180mg When Added to PCSK9 Inhibitor Therapy

  NCT03193047

  Condition:   Hypercholesterolemia
  Interventions:   Drug: bempedoic acid 180mg;   Other: placebo;   Drug: evolocumab
  Sponsor:   Esperion Therapeutics
  Completed
• The Efficacy of Single Coil Defibrillation Leads for Internal Cardioversion of Atrial Fibrillation

  NCT03164395

  Condition:   Atrial Fibrillation
  Interventions:   Procedure: Internal Cardioversion;   Procedure: External Cardioversion
  Sponsor:   University of Kentucky
  Completed
• Using CPAP to Improve Menstruation in Women With Polycystic Ovarian Syndrome and Obstructive Sleep Apnea

  NCT03155828

  Conditions:   Sleep Apnea, Obstructive;   Anovulation;   Polycystic Ovarian Syndrome
  Intervention:   Device: CPAP
  Sponsor:   University of Louisville
  Withdrawn
• Initial Evaluation of the Cellie Coping Kit for Children With Injury

  NCT03153696

  Condition:   Injuries
  Intervention:   Behavioral: Cellie Coping Kit Intervention
  Sponsors:   University of Kentucky;   Children's Hospital of Philadelphia
  Active, not recruiting
• Blood And Clot Thrombectomy Registry And Collaboration

  NCT03153683

  Condition:   Acute Ischemic Stroke
  Intervention:   Other: Registry
  Sponsors:   Justin Fraser;   University of Kentucky
  Recruiting
• Vitamin D for Muscle Metabolic Function in Cancer Cachexia

  NCT03144128

  Conditions:   Cancer Cachexia;   Vitamin D Deficiency
  Interventions:   Dietary Supplement: Vitamin D;   Dietary Supplement: Placebo
  Sponsor:   David Travis Thomas
  Recruiting
• Pharmacodynamic Open-Label Trial With VXA-A1.1 Oral H1 Vaccine in Healthy Adults

  NCT03121339

  Condition:   Seasonal Influenza Preventative Vaccine Pharmacodynamics
  Interventions:   Biological: VXA-A1.1 H1 Tablet Vaccine (small);   Biological: VXA-A1.1 H1 Tablet Vaccine (large)
  Sponsor:   Vaxart
  Completed
• VITOM Study: A Randomized, Controlled Trial.

  NCT03120689

  Conditions:   Pelvic Organ Prolapse;   Prolapse of Vaginal Vault After Hysterectomy;   Bulging of Vaginal Wall;   Incontinence;   Fistula
  Interventions:   Other: Live Surgery using VITOM;   Other: Live Surgery without VITOM;   Other: Video viewing with VITOM;   Other: Video viewing with standard handheld high-definition camera
  Sponsors:   University of Louisville;   KARL STORZ Endoscopy-America, Inc.
  Completed
• Assessing the Utility of Cognitive Behavioral Therapy for Pain Control in Patients With Chronic Pancreatitis

  NCT03112759

  Condition:   Chronic Pancreatitis
  Intervention:   Behavioral: Cognitive Behavioral Therapy
  Sponsor:   University of Louisville
  Unknown status
• Apolipoprotein E (ApoE) and Metabolism

  NCT03109561

  Conditions:   Cognitive Function;   Healthy
  Interventions:   Other: Resting State Indirect Calorimetry;   Genetic: ApoE;   Diagnostic Test: Metabolism;   Other: Cognitive Challenge
  Sponsor:   Lance Johnson
  Recruiting
• The Effect of Aromatherapy on Neonatal Abstinence Syndrome and Salivary Cortisol Levels

  NCT03097484

  Conditions:   Neonatal Abstinence Syndrome;   Aromatherapy
  Intervention:   Drug: lavender and chamomile essential oils
  Sponsor:   John M. Daniel
  Completed
• The INFUSE Trial - Intervening With Platelet Transfusions in Sepsis

  NCT03090919

  Conditions:   Sepsis;   Thrombocytopenia
  Interventions:   Biological: Platelet transfusion;   Other: Saline
  Sponsor:   University of Kentucky
  Recruiting
• Evaluating Genomic Testing in Human Cancer & Outcomes of Targeted Therapies

  NCT03089554

  Condition:   Cancer
  Intervention:   Drug: Therapeutic Intervention
  Sponsor:   Rachel Miller
  Recruiting
• A Study of Cisplatin or Carboplatin With Gemcitabine Versus Gemcitabine Alone as Adjuvant Therapy in Patients With Resected or Ablation Intra-Hepatic Cholangiocarcinoma

  NCT03081039

  Condition:   Intrahepatic Cholangiocarcinoma
  Interventions:   Drug: Carboplatin;   Drug: Cisplatin;   Drug: Gemcitabine
  Sponsor:   University of Louisville
  Withdrawn
• Immunotherapy and Irreversible Electroporation in the Treatment of Advanced Pancreatic Adenocarcinoma

  NCT03080974

  Condition:   Pancreatic Adenocarcinoma
  Interventions:   Drug: Nivolumab;   Procedure: Irreversible Electroporation
  Sponsor:   University of Louisville
  Recruiting
• Video-Laryngoscope Alone or With Bronchoscope for Predicted Difficult Intubation

  NCT03080896

  Condition:   Intubation; Difficult
  Interventions:   Device: King Vision video-laryngoscope with #3 disposable blade and endotracheal tube stylet;   Device: fiberoptic bronchoscope aScope III
  Sponsors:   University of Louisville;   Ambu A/S
  Recruiting
• Real World Data on Management of Male LUTS

  NCT03075449

  Condition:   Benign Prostatic Hyperplasia
  Intervention:  
  Sponsor:   Boehringer Ingelheim
  Completed
• Rural Intervention for Caregivers' Heart Health

  NCT03068390

  Condition:   Cardiovascular Risk Factor
  Interventions:   Behavioral: RICHH Intervention;   Behavioral: Usual care
  Sponsors:   Debra Moser;   National Institute of Nursing Research (NINR)
  Recruiting
• AT-001 for Long-term Preservation of Brain Health in Aging

  NCT03062384

  Condition:   Oxidative Stress
  Interventions:   Dietary Supplement: AT-001;   Dietary Supplement: Placebo
  Sponsors:   University of Kentucky;   Alltech Life Sciences Inc.
  Completed
• Brain Exercises for Synaptic Plasticity

  NCT03058055

  Condition:   Cognitive Change
  Interventions:   Behavioral: Placebo;   Behavioral: Origami;   Behavioral: Reading
  Sponsor:   University of Kentucky
  Completed
• Combining Opioid Addiction Treatment Services With CARe for Infectious Endocarditis

  NCT03048643

  Conditions:   Endocarditis, Bacterial;   Opioid-use Disorder;   Buprenorphine;   Outpatient Parenteral Antibiotic Therapy
  Intervention:   Behavioral: Outpatient parenteral antibiotic therapy
  Sponsor:   Laura Fanucchi
  Completed
• Stem Cell Heart Injections During Laser Revascularization Surgery for Treatment of Chronic Ischemic Heart Disease

  NCT03043742

  Condition:   Chronic Ischemic Heart Disease
  Intervention:   Drug: Bone Marrow Derived Autologous CD133+ Selected Cell Product
  Sponsor:   Michael Sekela
  Recruiting
• Cangrelor in ST-Elevation Myocardial Infarction to Decrease Infarct Size

  NCT03043274

  Condition:   STEMI - ST Elevation Myocardial Infarction
  Intervention:   Drug: Cangrelor
  Sponsor:   George Bennet, MD
  Recruiting
• Recovery of Bladder and Sexual Function After Spinal Cord Injury

  NCT03036527

  Condition:   Spinal Cord Injuries
  Interventions:   Procedure: Activity-based locomotor training;   Procedure: Activity-based stand training;   Procedure: Activity-based upper arm ergometry
  Sponsor:   University of Louisville
  Recruiting
• Two Radiation Dose Schedules of SBRT to Lung Metastases < 5cm in Dimension

  NCT03029416

  Conditions:   Neoplasm Metastasis;   Cancer;   Radiation Therapy Complication
  Intervention:   Radiation: Stereotactic Body Radiation Therapy
  Sponsor:   Ronald McGarry
  Withdrawn
• Biological Effects of Agent on PAR-4 Levels With Resected Solid Tumors

  NCT03015324

  Condition:   Solid Tumor
  Intervention:   Drug: Hydroxychloroquine
  Sponsor:   Peng Wang, MD PhD
  Recruiting
• Fosbretabulin With Everolimus in Neuroendocrine Tumors With Progression

  NCT03014297

  Conditions:   Neuroendocrine Tumors;   Everolimus
  Interventions:   Drug: everolimus;   Drug: fosbretabulin
  Sponsor:   Lowell Anthony, MD
  Terminated
• The Acute Cardiovascular Effects of Nicotine in E-cigarettes (ACE) Study

  NCT03010995

  Conditions:   Cigarette Smoking Toxicity;   Nicotine;   Acute Cardiovascular Disease
  Intervention:   Drug: Prazosin
  Sponsor:   University of Louisville
  Withdrawn
• Impact of an Intensive Monitoring Strategy in Symptomatic Patients With Suspected Arrhythmia

  NCT03001765

  Condition:   Suspected Arrhythmia
  Intervention:   Other: Intensive Monitoring Strategy: Reveal LINQ™ Insertable Cardiac Monitoring System".
  Sponsor:   St Elizabeth Healthcare
  Completed
• Use of Apremilast in Patients Who Are Dissatisfied With Stable Maintenance Topical Therapy

  NCT03000309

  Condition:   Plaque Psoriasis
  Intervention:   Drug: Apremilast
  Sponsors:   Derm Research, PLLC;   Celgene
  Completed
• Cisplatin + Radiation in SCCHN and Correlation With Oxidative Stress Markers

  NCT02994069

  Conditions:   Carcinoma, Squamous Cell;   Head and Neck Cancer
  Interventions:   Drug: Cisplatin;   Radiation: XRT
  Sponsor:   Susanne Arnold
  Recruiting
• A-dmDT390-bisFv(UCHT1) Fusion Protein With Ionizing Radiation and Pembrolizumab for the Treatment of Stage IV Melanoma

  NCT02990416

  Condition:   Stage IV Melanoma
  Interventions:   Biological: A-dmDT390-bisFv(UCHT1);   Biological: Pembrolizumab;   Radiation: Ionizing Radiation
  Sponsors:   Angimmune LLC;   James Graham Brown Cancer Center
  Unknown status
• TVB 2640 for Resectable Colon Cancer Other Resectable Cancers; a Window Trial.

  NCT02980029

  Condition:   Colon Cancer
  Interventions:   Drug: TVB-2640;   Other: Placebo
  Sponsor:   Mark Evers
  Recruiting
• Comparison of Albuterol for Status Asthmaticus

  NCT02966184

  Condition:   Status Asthmaticus
  Intervention:   Drug: preservative free albuterol
  Sponsor:   Norton Healthcare
  Suspended
• Dietary Sources of Lysophospholipids

  NCT02952638

  Conditions:   Obesity;   Cardiovascular Risk Factor;   Hyperlipidemia
  Intervention:  
  Sponsor:   University of Kentucky
  Recruiting
• Expressions of TRPV1 in Airway of Asthmatics

  NCT02952066

  Conditions:   Moderate Persistent Asthma;   Severe Persistent Asthma;   Nodule Solitary Pulmonary;   Pulmonary Atelectasis
  Intervention:   Procedure: Bronchial biopsy
  Sponsor:   Lu Yuan Lee
  Active, not recruiting
• IL-1RA Treatment in Patients With Acute ACL Tear and Painful Effusions

  NCT02930122

  Condition:   Anterior Cruciate Ligament Tear
  Interventions:   Drug: Saline (0.9%) and anakinra (150mg);   Drug: anakinra (150mg) and Saline (0.9%);   Other: Saline intraarticularly
  Sponsors:   Cale Jacobs, PhD;   Arthritis Foundation
  Recruiting
• Electronic Decision Support for Intervention in Poorly Controlled Type 2 Diabetes

  NCT02924207

  Condition:   Diabetes Mellitus
  Intervention:   Other: PATH electronic decision support tool
  Sponsors:   St Elizabeth Healthcare;   PATH Decision Support Software, LLC
  Completed
• Brown Fat Activation Study

  NCT02919176

  Conditions:   Obese;   Metabolic Syndrome
  Interventions:   Drug: Mirabegron;   Drug: Pioglitazone;   Drug: Mirabegron and Pioglitazone
  Sponsors:   Philip Kern;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
  Recruiting
• Magnesium And Verapamil After Recanalization in Ischemia of the Cerebrum: a Clinical and Translational Study.

  NCT02912663

  Condition:   Ischemic Stroke
  Interventions:   Drug: Verapamil and Magnesium Sulfate;   Other: Placebo
  Sponsor:   Justin Fraser
  Recruiting
• Vaginal and Urinary Microbiome Trial

  NCT02869165

  Conditions:   Atrophic Vaginitis;   Menopause;   Recurrent Urinary Tract Infections
  Interventions:   Drug: Premarin vaginal cream;   Drug: Apricot kernel oil
  Sponsor:   University of Louisville
  Unknown status
• Responsible Fatherhood Opportunities for Reentry & Mobility

  NCT02860988

  Condition:   Substance Use Disorders
  Intervention:   Behavioral: MCCC treatment
  Sponsors:   Mountain Comprehensive Care Center;   University of Kentucky
  Recruiting
• Hodgkin Lymphoma Molecular Profiling and Clinical Outcomes in U.S. Community Oncology Practices

  NCT02856646

  Condition:   Hodgkin's Disease
  Intervention:  
  Sponsor:   Bristol-Myers Squibb
  Recruiting
• The INCREASE Study - Delaying the Onset of Alzheimer's Symptomatic Expression

  NCT02849639

  Conditions:   Alzheimer's Disease;   Dementia
  Interventions:   Other: Placebo;   Other: Medication Therapy Management (MTM);   Drug: Scopolamine patch
  Sponsors:   Daniela Moga;   National Institute on Aging (NIA)
  Recruiting
• The Effects of Spinal Manipulation on Central Nervous System Activity Measured by Reflexive Calf Muscle Recruitment

  NCT02848456

  Condition:   Subluxation of Joint of Lumbar Spine
  Interventions:   Procedure: Spinal Manipulation;   Procedure: Max Voluntary Isometric Contraction;   Procedure: SM+MVIC
  Sponsors:   Grant Sanders;   University of Kentucky
  Completed
• Preoperative Nutrition With Immune Enhancing Nutritional Supplement (Immunomodulation)

  NCT02838966

  Condition:   Pancreatic Adenocarcinoma
  Interventions:   Dietary Supplement: Nestle IMPACT Advanced Recovery;   Dietary Supplement: Nestle Boost High Protein Drink
  Sponsors:   University of Louisville;   Nestlé
  Unknown status
• Intermittent Hypoxemia and Acute Kidney Injury Study (IHAKI Study)

  NCT02837276

  Conditions:   Intermittent Hypoxemia;   Acute Kidney Injury;   Preterm Infant
  Intervention:  
  Sponsors:   Elie G. Abu Jawdeh, MD;   University of Kentucky
  Completed
• Superselective Citicoline and Verapamil for Ischemic Neuroprotection and Greater Effective Response

  NCT02823106

  Condition:   Ischemic Stroke
  Interventions:   Drug: Verapamil and Citicoline;   Other: Placebo
  Sponsor:   Justin Fraser
  Withdrawn
• Root Coverage Comparing an Allograft to a Bovine Xenograft

  NCT02810067

  Condition:   Gingival Recession
  Interventions:   Procedure: Tunnel + AlloDerm;   Procedure: Tunnel + Novomatrix
  Sponsor:   University of Louisville
  Withdrawn
• Ridge Preservation Comparing the Healing With or Without a Barrier Membrane

  NCT02798887

  Condition:   Jaw, Edentulous, Partially
  Intervention:   Procedure: Ridge preservation
  Sponsor:   University of Louisville
  Not yet recruiting
• Shopping Smart - Adolescent Intervention to Improve Shopping Practices Where You Live and Learn

  NCT02793024

  Condition:   Food Choices
  Intervention:   Behavioral: Intervention
  Sponsors:   Alison Gustafson;   East Carolina University
  Completed
• Outcomes of Renal Function in Hepatorenal Syndrome (HRS) Determined By Comparison of Target Mean Arterial Pressure (MAP) of 65 - 70 Mmhg Versus ≥ 85 Mmhg

  NCT02789150

  Condition:   Hepatorenal Syndrome
  Intervention:   Drug: Norepinephrine (Levophed)
  Sponsor:   University of Louisville
  Completed
• Diagnostic Value of Passive Leg Raise Induced Changes in Carotid Artery Flow Time to Predict Fluid Responsiveness in Critically Ill Patients

  NCT02789124

  Conditions:   Fluid Responsiveness;   Carotid Artery Flow Time;   Passive Leg Raise
  Intervention:   Other: Carotid Doppler Measurement in response to passive leg raise
  Sponsor:   University of Louisville
  Completed