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• The Use of Music for Neonates Post-Cardiac Surgery

  NCT03925584

  Condition:   Heart Defects, Congenital
  Intervention:   Other: Music Therapy
  Sponsor:   Boston Children’s Hospital
  Recruiting
• Testing a Brief Substance Misuse Preventative Intervention for Parents/Guardians of 5th-7th Grade Students

  NCT03925220

  Conditions:   Substance-Related Disorders;   Underage Drinking;   Drug Use
  Interventions:   Behavioral: The SUPPER Project;   Behavioral: Improving nutrition and physical activity among youth
  Sponsors:   Tufts University;   Brown University
  Recruiting
• A Clinical Trial Via Telepsychiatry of Treatments for the Management of Emotional Dysregulation in Youth

  NCT03911414

  Conditions:   Mood Disturbance;   Mood Disorders;   Natural Supplements;   Alternative Treatment
  Interventions:   Drug: Open-label Treatment with Omega-3 Fatty Acids + Inositol;   Drug: Open-label Treatment with N-acetylcysteine
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Monitoring Of Scratch Via Accelerometry In Children

  NCT03873220

  Condition:   Atopic Dermatitis
  Interventions:   Device: Wrist Actigraphy Devices;   Device: Sleep Monitor;   Device: Polysomnography;   Device: Videography
  Sponsor:   Boston University
  Recruiting
• Continuous Erector Spinae Block Versus Continuous Paravertebral Block

  NCT03768440

  Condition:   Pain, Postoperative
  Interventions:   Procedure: continuous erector spinae block (ESB);   Procedure: continuous paravertebral block (PVB);   Drug: Ropivacaine
  Sponsor:   Boston Children’s Hospital
  Recruiting
• Natural Treatments for the Management of Emotional Dysregulation in Youth With Non-verbal Learning Disability (NVLD) and/or Autism Spectrum Disorders (ASD)

  NCT03757585

  Conditions:   Non-verbal Learning Disorder;   Autism Spectrum Disorder;   Autism
  Interventions:   Drug: Open-label Treatment with Omega-3 Fatty Acids + Inositol;   Drug: Open-label Treatment with N-acetylcysteine
  Sponsors:   Massachusetts General Hospital;   Demarest Lloyd Jr. Foundation
  Recruiting
• Improving Therapeutic Patient Education for Atopic Dermatitis: Evaluation of a Parent Handbook

  NCT03722706

  Condition:   Dermatitis, Atopic
  Intervention:   Other: Educational handbook
  Sponsors:   Boston Children’s Hospital;   Pfizer
  Recruiting
• Stress Ulcer Prophylaxis Versus Placebo in Critically Ill Infants With Congenital Heart Disease

  NCT03667703

  Conditions:   Congenital Heart Disease;   Upper Gastrointestinal Bleeding;   Stress Ulcer;   Infection
  Interventions:   Drug: Ranitidine;   Drug: Placebo
  Sponsors:   Boston Children’s Hospital;   The Gerber Foundation
  Recruiting
• CenteringParenting Clinical Intervention on Kindergarten Readiness in Early Childhood

  NCT03641092

  Conditions:   Parent-Child Relations;   Parenting;   Child Development;   Child Behavior
  Interventions:   Behavioral: CenteringParenting Intervention;   Behavioral: Routine Well Child Care
  Sponsors:   Boston Medical Center;   Centering Healthcare Institute;   Overdeck Family foundation;   Valhalla Charitable Foundation
  Recruiting
• Pilot Feasibility of the Pediatric Cancer Resource Equity (PediCARE) Intervention

  NCT03638453

  Condition:   Other Cancer
  Interventions:   Other: PediCARE;   Other: Usual Care
  Sponsors:   Dana-Farber Cancer Institute;   Charles H. Hood Foundation;   National Cancer Institute (NCI)
  Recruiting
• Pharmacokinetics of Sedatives and Analgesics During Extracorporeal Membrane Oxygenation (ECMO) Support

  NCT03593408

  Condition:   Drug Effect
  Interventions:   Drug: Dexmedetomidine;   Drug: Fentanyl;   Drug: Midazolam;   Drug: Morphine
  Sponsor:   Boston Children’s Hospital
  Recruiting
• Sympathetic Nervous System Mediation of Acute Exercise Effects on Childhood Brain and Cognition

  NCT03592238

  Conditions:   Exercise;   Cognition
  Interventions:   Other: Aerobic Exercise Intervention;   Other: Trier Social Stress Test for Children;   Other: Seated Rest
  Sponsor:   Northeastern University
  Recruiting
• Pharmacokinetics of Bivalirudin for Pediatric Anticoagulation

  NCT03532399

  Condition:   Drug Effect
  Intervention:   Drug: Bivalirudin
  Sponsor:   Boston Children’s Hospital
  Recruiting
• Boston Outcomes of Autism in Toddlers Study

  NCT03517163

  Conditions:   Autism Spectrum Disorder;   Autism
  Intervention:  
  Sponsor:   Boston Children’s Hospital
  Recruiting
• Interactive Parent-Targeted Text Messaging in Pediatric Clinics to Reduce Caries Among Urban Children

  NCT03294590

  Conditions:   Caries, Dental;   Health Behavior
  Interventions:   Other: OHT Parent targeted text messages;   Other: CWT Parent targeted text messages
  Sponsors:   Boston University;   National Institute of Dental and Craniofacial Research (NIDCR)
  Recruiting
• Evaluation of UDP-glucose as a Urinary Biomarker for Early Detection of Cardiac Surgery-associated Pediatric Acute Kidney Injury

  NCT03263325

  Condition:   Acute Kidney Injury
  Intervention:   Other: Discarded urine sample
  Sponsor:   Boston Children’s Hospital
  Recruiting
• Validation of Thermal Imaging to Detect Pneumonia

  NCT03261479

  Condition:   Pneumonia
  Intervention:   Diagnostic Test: Thermal image
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Quantitative Assessment of Sucking for Early Diagnosis of Brain Injury in Infants at High Risk

  NCT03246243

  Condition:   Hypoxic-Ischemic Encephalopathy
  Interventions:   Device: nfant feeding solution;   Device: Waveguard (TM) EEG cap;   Device: BabyMEG
  Sponsors:   Boston Children’s Hospital;   Beth Israel Deaconess Medical Center;   Winchester Hospital
  Recruiting
• Environmental Assessment of Sleep in Youth

  NCT03224455

  Conditions:   Sleep Disorders in Children;   Environmental Exposure
  Intervention:  
  Sponsors:   Boston Children’s Hospital;   Brigham and Women's Hospital
  Recruiting
• The Effect of General Anesthesia on Pharmacokinetics of Oxycodone in Pediatric

  NCT03054831

  Condition:   Liquid Oxycodone
  Intervention:   Drug: liquid oxycodone
  Sponsor:   Boston Children’s Hospital
  Recruiting
• Outcomes of an Intraoperative Bispectral Index Monitor

  NCT03052543

  Condition:   Anesthesia
  Intervention:   Device: BIS™ Complete 2--Channel Monitor
  Sponsor:   Boston Children’s Hospital
  Recruiting
• Improving Neurodevelopmental Outcomes in Children With Congenital Heart Disease: An Intervention Study

  NCT03023644

  Conditions:   Congenital Heart Defect;   Executive Function;   Children;   Neurodevelopmental Disorders;   Working Memory;   Infant Open Heart Surgery
  Intervention:   Behavioral: Cogmed Working Memory Training
  Sponsors:   Boston Children’s Hospital;   United States Department of Defense
  Recruiting
• Robotic-assisted Therapy to Improve Manual Dexterity in Children With Cerebral Palsy

  NCT02923167

  Condition:   Cerebral Palsy
  Intervention:   Device: Robotic-assisted training of the hand
  Sponsor:   Spaulding Rehabilitation Hospital
  Recruiting
• Mental Imagery Therapy for Autism (MITA) - an Early Intervention Computerized Brain Training Program for Children With ASD

  NCT02708290

  Conditions:   Autistic Disorder;   Autism;   ASD
  Intervention:   Other: MITA visual puzzles - Each game adapts to deliver the exercise that is at the exact level of difficulty appropriate for a child at any given point in time
  Sponsor:   ImagiRation, LLC
  Recruiting
• Observational Prospective Study on Behavioral Outcomes of Children With Autism Spectrum Disorder (ASD) in Comparison to Those Without Neurodevelopmental Diagnoses

  NCT02707939

  Conditions:   Autism Spectrum Disorder;   Anesthesia
  Intervention:   Other: Observation
  Sponsor:   Boston Children’s Hospital
  Recruiting
• Orchidopexy Randomized Clinical Assessment

  NCT02235623

  Condition:   Unilateral Cryptorchidism
  Interventions:   Procedure: Single-stage Fowler-Stephens orchidopexy (FSO);   Procedure: Two-stage Fowler-Stephens orchidopexy (FSO)
  Sponsor:   Boston Children’s Hospital
  Recruiting
• Tau/P-Tau and Neurocognitive Outcomes in Children

  NCT03511729

  Conditions:   General Anesthetics Toxicity;   Postoperative Cognitive Dysfunction;   Child Development
  Intervention:  
  Sponsor:   Massachusetts General Hospital
  Recruiting
• A Clinical Trial of Pulsed-dye Laser Versus Timolol Topical Solution Versus Observation on the Growth of Hemangioma in Newborn

  NCT01873131

  Condition:   Hemangioma
  Interventions:   Drug: topical timolol maleate;   Device: Pulsed dye laser
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Flexible Electronics for Early Assessment

  NCT03034785

  Condition:   Very Low Birth Weight Infant
  Intervention:   Device: FlexiMitt
  Sponsors:   Wyss Institute at Harvard University;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   Beth Israel Deaconess Medical Center
  Recruiting
• Testing a Novel Speech Intervention in Minimally Verbal Children With Autism Spectrum Disorder (ASD)

  NCT03015272

  Condition:   Autism
  Interventions:   Behavioral: Auditory-Motor Mapping Training;   Behavioral: Speech-Repetition Therapy
  Sponsors:   Beth Israel Deaconess Medical Center;   Boston University
  Recruiting
• Kisspeptin in the Evaluation of Delayed Puberty

  NCT01438034

  Conditions:   Delayed Puberty;   Kallmann Syndrome;   Hypogonadotropic Hypogonadism;   GnRH Deficiency
  Interventions:   Drug: kisspeptin 112-121;   Drug: GnRH
  Sponsor:   Massachusetts General Hospital
  Recruiting
• NIRS Monitoring in Premature Infants

  NCT02601339

  Conditions:   Hemorrhage;   Premature Infants;   Newborn;   Hydrocephalus
  Intervention:   Procedure: ETV/CPC
  Sponsors:   Boston Children’s Hospital;   Brigham and Women's Hospital;   Beth Israel Deaconess Medical Center;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
  Recruiting
• Safety Study of a Novel Wearable Phototherapy System for the Management of Acute Burn Wounds

  NCT03948360

  Condition:   Burn Wound
  Interventions:   Device: Low-Irradiance Monochromatic Biostimulation (LIMB) Device;   Other: Standard of Care
  Sponsor:   Rogers Sciences Inc.
  Recruiting
• VE416 for Treatment of Food Allergy

  NCT03936998

  Condition:   Peanut Allergy
  Interventions:   Combination Product: Vancomycin plus VE416 before PNOIT;   Combination Product: Vancomycin plus VE416 with PNOIT;   Combination Product: Placebo plus VE416 with PNOIT;   Combination Product: Placebo plus placebo with PNOIT
  Sponsors:   Massachusetts General Hospital;   Vedanta Biosciences, Inc.
  Recruiting
• Study of the Bromodomain (BRD) and Extra-Terminal Domain (BET) Inhibitor BMS-986158 in Pediatric Cancer

  NCT03936465

  Conditions:   Solid Tumor, Childhood;   Lymphoma;   Brain Tumor, Pediatric
  Intervention:   Drug: BMS-986158
  Sponsors:   Dana-Farber Cancer Institute;   Stand Up To Cancer
  Recruiting
• Association Between Activity and PROMIS Pediatric Measures in Children With Asthma

  NCT03933540

  Condition:   Pediatric Asthma
  Intervention:  
  Sponsors:   Duke University;   University of North Carolina, Chapel Hill;   Boston Children’s Hospital
  Recruiting
• Pharmacokinetics of Antibiotics During Extracorporeal Membrane Oxygenation (ECMO) Support

  NCT03922451

  Condition:   Drug Effect
  Interventions:   Drug: piperacillin-tazobactam;   Drug: Cefazolin
  Sponsor:   Boston Children’s Hospital
  Recruiting
• Effects of Green Light Exposure on Epileptic Spikes in Patients With Refractory Epilepsy

  NCT03857074

  Conditions:   Epilepsy;   Epilepsy Intractable
  Intervention:   Device: Green Light Exposure
  Sponsor:   Boston Children’s Hospital
  Recruiting
• SIMDiscovery: The Benefits of Utilizing a Simulation Preparation Program for Spinal Fusion Surgery

  NCT03835390

  Condition:   Scoliosis Idiopathic Adolescent
  Intervention:   Behavioral: SIMDiscovery
  Sponsor:   Boston Children’s Hospital
  Recruiting
• Association of Platelet Parameters With Bleeding Severity in Children With ITP

  NCT03810352

  Condition:   Immune Thrombocytopenia
  Intervention:  
  Sponsors:   Boston Children’s Hospital;   Sysmex America, Inc.;   Children's Hospital Colorado;   Children's Hospital of Philadelphia;   Texas Children's Hospital;   Columbia University;   Duke University
  Recruiting
• Pilot Trial of Contingency Management for Long-Term Cannabis Abstinence

  NCT03786224

  Conditions:   Cannabis Use;   Adolescent Behavior
  Intervention:   Behavioral: Contingency Management
  Sponsor:   Massachusetts General Hospital
  Recruiting
• A Stress Management and Resiliency Program for Adolescent and Young Adult Survivors

  NCT03768336

  Condition:   Cancer
  Interventions:   Other: Waitlist control;   Other: 3RP-AYA
  Sponsors:   Massachusetts General Hospital;   National Cancer Institute (NCI)
  Recruiting
• Psychological Skills Group for Youth of Refugee and Immigrant Backgrounds

  NCT03763591

  Conditions:   Stress, Psychological;   Acculturation Problem
  Intervention:   Behavioral: Trauma Systems Therapy for Refugees Group Intervention
  Sponsor:   Boston Children’s Hospital
  Recruiting
• The Role of Estrogen in the Neurobiology of Eating Disorders

  NCT03740204

  Conditions:   Eating Disorders;   Hypoestrogenemia
  Interventions:   Drug: 17-β estradiol transdermal patches with cyclic progesterone;   Drug: Placebo patch and pill
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Using Virtual Reality for Patients With Gastrointestinal Disease

  NCT03719209

  Conditions:   Gastrointestinal Disease;   Inflammatory Bowel Diseases
  Interventions:   Other: HealthVoyager;   Other: Standard Practice
  Sponsors:   Boston Children’s Hospital;   Klick Health
  Recruiting
• Multi-modal Neuroimaging in Children With Cerebral Palsy or Brachial Plexus Birth Palsy

  NCT03712072

  Conditions:   Cerebral Palsy;   Brachial Plexus; Injury, Newborn
  Interventions:   Device: Magnetoencephalography (MEG);   Device: Electroencephalography (EEG);   Device: Transcranial Magnetic Stimulation (TMS)
  Sponsor:   Boston Children’s Hospital
  Recruiting
• Memantine for the Treatment of Social Deficits in Youth With Disorders of Impaired Social Interactions

  NCT03553875

  Conditions:   Autism;   Autism Spectrum Disorder;   Nonverbal Learning Disability
  Interventions:   Drug: Memantine Hydrochloride;   Drug: Placebo
  Sponsor:   Massachusetts General Hospital
  Recruiting
• A 90 Day, Phase 4,Open Labeled Exploratory Study of RELiZORB

  NCT03530852

  Conditions:   Short Bowel Syndrome;   Malabsorption
  Intervention:   Device: Relizorb
  Sponsors:   Boston Children’s Hospital;   Alcresta Therapeutics, Inc.
  Recruiting
• Effects of Home Gluten Immunogenic Peptide Testing on Children With Celiac Disease

  NCT03462979

  Conditions:   Celiac Disease;   Gluten Sensitivity;   Gluten Enteropathy;   Gastrointestinal Disease;   Digestive System Disease;   Diet Modification;   Intestinal Disease;   Malabsorption Syndromes;   Patient Compliance;   Diagnostic Self Evaluation;   Quality of Life
  Intervention:   Device: Immunochromatographic lateral flow test
  Sponsors:   Boston Children’s Hospital;   Glutenostics, LLC
  Recruiting
• Child HCAHPS: Automated Day of Discharge Survey

  NCT03441503

  Conditions:   Inpatient Experience Survey Administration;   Inpatient Experience Survey Response
  Intervention:   Other: Child HCAHPS: Automated day-of-discharge survey
  Sponsors:   Boston Children’s Hospital;   GetWellNetwork;   Dayton Children's Hospital
  Recruiting
• Pilot Study of Metformin for Patients With Fanconi Anemia

  NCT03398824

  Condition:   Fanconi Anemia
  Intervention:   Drug: metformin HCl
  Sponsor:   Boston Children’s Hospital
  Recruiting
• Proton Craniospinal Irradiation With Bone Sparing to Decrease Growth Decrement From Radiation

  NCT03281889

  Condition:   Brain Tumor
  Intervention:   Radiation: Proton Beam
  Sponsors:   Massachusetts General Hospital;   National Cancer Institute (NCI)
  Recruiting
• Web-based Insomnia Treatment for Adolescent and Young Adult Cancer Survivors

  NCT03279055

  Condition:   Insomnia
  Intervention:   Behavioral: SHUTi
  Sponsors:   Dana-Farber Cancer Institute;   Alex's Lemonade Stand Foundation
  Recruiting
• Protease Activated Receptor-2 and Gastrointestinal Dysfunction in Critical Illness

  NCT03011151

  Conditions:   Gastroparesis;   Gastrointestinal Disorder, Functional;   Critical Illness
  Intervention:  
  Sponsor:   Boston Children’s Hospital
  Recruiting
• Cognitive-Behavioral Therapy for Avoidant/Restrictive Food Intake Disorder: A Treatment Development and Pilot Study

  NCT02963220

  Condition:   Avoidant/Restrictive Food Intake Disorder (ARFID)
  Intervention:   Behavioral: CBT-AR
  Sponsors:   Massachusetts General Hospital;   American Psychological Foundation;   The Hilda & Preston Davis Foundation
  Recruiting
• The Synergistic Effect of Dexmedetomidine on Propofol for Sedation for Pediatric Endoscopy

  NCT02952222

  Condition:   Anesthesia
  Interventions:   Drug: Dexmedetomidine;   Drug: Propofol (Group P);   Drug: Propofol (Group DP)
  Sponsor:   Keira Mason
  Recruiting
• Treatment With Quetiapine for Youth With Substance Use Disorders and Severe Mood Dysregulation

  NCT02845453

  Conditions:   Substance Use Disorders;   Bipolar Disorder;   Mood Disorders
  Interventions:   Drug: Quetiapine;   Drug: Placebo
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Validation of the Hospital Asthma Severity Score (HASS)

  NCT02782065

  Condition:   Asthma
  Intervention:   Other: Not an interventional study
  Sponsor:   Boston Children’s Hospital
  Recruiting
• Phase I/II Trial of Everolimus in Combination With Lonafarnib in Progeria

  NCT02579044

  Condition:   Progeria
  Intervention:   Drug: Everolimus and lonafarnib
  Sponsor:   Boston Children’s Hospital
  Recruiting
• Safety and Tolerability of Intravenous Fish Oil Lipid Emulsion in Children Undergoing Hematopoietic Cell Transplantation

  NCT02512718

  Condition:   Hematopoietic Stem Cell Transplantation
  Interventions:   Drug: Omegaven;   Drug: Soybean oil lipid emulsion
  Sponsor:   Alexandra N. Carey
  Recruiting
• Effects of High Flow Nasal Cannula on Deadspace Reduction and Regional Distribution of Ventilation

  NCT02460653

  Conditions:   Respiratory Insufficiency;   Hypoxia
  Intervention:   Device: HFNC Flow Rate
  Sponsor:   Boston Children’s Hospital
  Recruiting
• Confocal Fluorescence Microscopy of the Human Airways in Diagnostics of Lung Transplantation

  NCT02395393

  Condition:   Disorder Related to Lung Transplantation
  Intervention:   Device: Alveoflex Confocal MiniprobeTM
  Sponsor:   Boston Children’s Hospital
  Recruiting
• Genomic Medicine for Ill Neonates and Infants (The GEMINI Study)

  NCT03890679

  Condition:   Pediatric: Genetic Syndrome
  Intervention:   Diagnostic Test: rapid whole genomic sequencing (rWGS)
  Sponsors:   Tufts Medical Center;   Rady Children's Hospital, San Diego;   Children's Hospital Medical Center, Cincinnati;   MOUNT SINAI HOSPITAL;   N.C. Children's Hospital;   University of Pittsburgh
  Recruiting
• Phase II Study of Proton Radiation Therapy for Neuroblastoma

  NCT02112617

  Conditions:   Neuroblastoma;   Ganglioneuroblastoma
  Intervention:   Radiation: Proton Beam Radiation Therapy
  Sponsors:   Massachusetts General Hospital;   National Cancer Institute (NCI)
  Recruiting
• A Prospective Controlled Treatment Trial for Post-Traumatic Headaches

  NCT03007420

  Condition:   Post-Traumatic Headaches
  Interventions:   Drug: Occipital Nerve Block (ONB) using lidocaine and dexamethosone;   Drug: Cervical Medial Branch Block (CMBB) using lidocaine and dexamethosone
  Sponsors:   Boston Children’s Hospital;   Beth Israel Deaconess Medical Center;   Harvard University
  Recruiting
• Regional Distribution Differences Between Neurally Adjusted Ventilatory Assist and Pressure Support Ventilation

  NCT01504373

  Condition:   Respiratory Failure
  Intervention:   Device: Neurally Adjusted Ventilatory Assist (NAVA)
  Sponsor:   Boston Children’s Hospital
  Recruiting
• Bone Mineral Density Status in Pediatric and Adolescent Survivors of Childhood Cancer With History of Bone Fracture

  NCT02355340

  Conditions:   Bone Mineral Density;   Childhood Cancer Survivors
  Interventions:   Other: Dual energy x-ray absorptiometry (DXA);   Other: Peripheral quantitative computed tomography (pQCT)
  Sponsor:   Dana-Farber Cancer Institute
  Recruiting
• Bronchopulmonary Disease (BPD) Patient Registry

  NCT00951366

  Condition:   Bronchopulmonary Disease
  Intervention:   Other: Patient Registry
  Sponsor:   Boston Children’s Hospital
  Recruiting
• TAK-580 In Gliomas and Other Tumors

  NCT03429803

  Condition:   Low-grade Glioma
  Intervention:   Drug: TAK-580
  Sponsors:   Karen D. Wright MD;   PALGA foundation;   Millennium Pharmaceuticals, Inc.;   National Cancer Institute (NCI);   Pacific Pediatric Neuro-Oncology Consortium;   Team Jack Foundation
  Recruiting
• Stereotactic Body Radiotherapy (SBRT) for Pulmonary Metastases in Ewing Sarcoma, Rhabdomyosarcoma, and Wilms Tumors

  NCT02581384

  Conditions:   Ewing Sarcoma;   Rhabdomyosarcoma;   Wilms Tumor;   Osteosarcoma;   Non-Rhabdomyosarcoma Soft Tissue Sarcoma, Nos;   Renal Tumor;   Rhabdoid Tumor;   Clear Cell Renal Cell Carcinoma;   Sarcoma;   Sarcoma, Ewing;   Soft Tissue Sarcoma
  Intervention:   Radiation: Stereotactic Body Radiotherapy (SBRT)
  Sponsor:   Dana-Farber Cancer Institute
  Recruiting
• LET Optimized IMPT in Treating Pediatric Patients With Ependymoma

  NCT03750513

  Conditions:   Anaplastic Ependymoma;   Ependymoma
  Interventions:   Radiation: Linear Energy Transfer-Optimized Intensity Modulated Proton Therapy;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration
  Sponsors:   M.D. Anderson Cancer Center;   National Cancer Institute (NCI)
  Recruiting
• Phase 1 Study of the Dual MDM2/MDMX Inhibitor ALRN-6924 in Pediatric Cancer

  NCT03654716

  Conditions:   Leukemia;   Brain Tumor;   Solid Tumor;   Lymphoma
  Interventions:   Drug: ALRN-6924;   Drug: Cytarabine
  Sponsors:   Dana-Farber Cancer Institute;   TeamConnor Childhood Cancer Foundation;   Cookies for Kids' Cancer;   Aileron Therapeutics
  Recruiting
• Targeting Surgeons' Decision-Making for Cleft Lip Surgery

  NCT03537976

  Conditions:   Cleft Palate;   Cleft Lip
  Intervention:   Other: Static Images and Facial Videos
  Sponsors:   Tufts University;   University of North Carolina, Chapel Hill;   Wake Forest University Health Sciences;   Boston Children’s Hospital;   Massachusetts General Hospital;   Tufts Medical Center;   University of Bath
  Recruiting
• Patient and Parent Preferences for an On-Body Automated Insulin Delivery System

  NCT03534544

  Condition:   Diabetes Mellitus, Type 1
  Intervention:  
  Sponsors:   Joslin Diabetes Center;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
  Recruiting
• Trial Evaluating an Enhanced Physical Activity Intervention to Improve Cognitive Late Effects in Children Treated With Cranial Radiation for Brain Tumors

  NCT02153957

  Condition:   Brain Tumor
  Intervention:   Behavioral: Physical Activity
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Understanding Patient Experience and Preferences for the QT Scanner Compared to Mammography

  NCT04057391

  Condition:   Patient Experience, Satisfaction and Preference
  Intervention:   Diagnostic Test: QT Scanner
  Sponsors:   QT Ultrasound LLC;   Analysis Group, Inc.
  Recruiting
• Diagnostic and Prognostic Biomarkers for Childhood Bacterial Pneumonia

  NCT03996967

  Conditions:   Pneumonia, Bacterial;   Viral Infection;   Clinical Pneumonia;   Plasmodium Falciparum Malaria;   Malaria;   Infections, Respiratory
  Intervention:  
  Sponsors:   Boston University;   National Institute of Allergy and Infectious Diseases (NIAID);   Medical Research Council Unit, The Gambia, LSTMH;   Laboratory of Transnational Immunology, UMC Utrecht
  Recruiting
• Scratch Behavior Under Standard of Care

  NCT03898427

  Condition:   Atopic Dermatitis
  Interventions:   Device: Wrist Actigraphy Devices;   Device: Polysomnography;   Device: Videography
  Sponsor:   Boston University
  Recruiting
• Small-group, Virtual Program for Improving Symptoms and Distress Related to Hormonal Therapy for Breast Cancer Survivors

  NCT03837496

  Conditions:   Breast Cancer;   Adherence, Medication
  Interventions:   Other: STRIDE;   Other: Medication Monitoring Control
  Sponsors:   Massachusetts General Hospital;   National Cancer Institute (NCI)
  Recruiting
• Clinical Trial to Improve the Magnetic Levator Prosthesis

  NCT03818204

  Conditions:   Blepharoptosis;   Ptosis, Eyelid;   Myasthenia Gravis;   Stroke;   Traumatic Brain Injury
  Intervention:   Device: Magnetic Levator Prosthesis (MLP)
  Sponsor:   Massachusetts Eye and Ear Infirmary
  Recruiting
• Calcitriol Monotherapy for X-Linked Hypophosphatemia

  NCT03748966

  Conditions:   X-linked Hypophosphatemia;   Hypophosphatemic Rickets;   Hypophosphatemic Rickets, X-Linked Dominant
  Intervention:   Drug: Calcitriol
  Sponsors:   Massachusetts General Hospital;   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
  Recruiting
• Pediatric Gastroparesis Registry

  NCT03680820

  Conditions:   Gastroparesis;   Gastroparesis-like Syndrome
  Intervention:  
  Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
  Recruiting
• Scheduled Ketorolac Administration After Cesarean Section and Its Effect on Opioid Consumption: a Randomized Control Trial

  NCT03678675

  Conditions:   Post-operative Pain;   Post-partum Pain;   Cesarean Section Complications
  Intervention:   Drug: Ketorolac
  Sponsor:   Tufts Medical Center
  Recruiting
• Seizure Rescue Medication: Caregiver Education in a Simulation Setting

  NCT03562351

  Condition:   Status Epilepticus
  Interventions:   Other: Verbal Instructions Educational Intervention;   Other: Video Educational Intervention;   Other: Mannequin Educational Intervention
  Sponsor:   Boston Children’s Hospital
  Recruiting
• Predictors of Sepsis in Ex-Preterm Infants

  NCT03433846

  Conditions:   Sepsis;   Premature Birth
  Intervention:  
  Sponsor:   Boston Children’s Hospital
  Recruiting
• Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies

  NCT03059420

  Conditions:   Congenital Fibrosis of Extraocular Muscles;   Duane Retraction Syndrome;   Duane Radial Ray Syndrome;   Mobius Syndrome;   Brown Syndrome;   Marcus Gunn Syndrome;   Strabismus Congenital;   Horizontal Gaze Palsy;   Horizontal Gaze Palsy With Progressive Scoliosis;   Facial Palsy;   Facial Paresis, Hereditary, Congenital;   Third Nerve Palsy;   Fourth Nerve Palsy;   Sixth Nerve Palsy;   Synkinesis;   Ocular Motility Disorders;   Levator-Medial Rectus Synkinesis;   Athabaskan Brainstem Dysgenesis;   Tongue Paralysis;   Ninth Nerve Disorder;   Fifth Nerve Palsy;   Seventh Nerve Palsy;   Eleventh Nerve Disorder;   Twelfth Nerve Disorder;   Vagus Nerve Paralysis;   Moebius Sequence
  Intervention:  
  Sponsors:   Boston Children’s Hospital;   Howard Hughes Medical Institute;   National Eye Institute (NEI)
  Recruiting
• Low Dose Naltrexone for Chronic Pain From Arthritis

  NCT03008590

  Conditions:   Osteoarthritis;   Arthritis, Rheumatoid;   Arthritis, Psoriatic
  Interventions:   Drug: Naltrexone;   Drug: Placebo
  Sponsor:   VA Office of Research and Development
  Recruiting
• Prospective Evaluation of Infants With Spinal Muscular Atrophy:

  NCT02831296

  Condition:   Spinal Muscular Atrophy
  Intervention:  
  Sponsors:   Massachusetts General Hospital;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   University of Utah;   University of Massachusetts, Worcester;   ARUP Laboratories;   Newborn Screening Translational Research Network;   American College of Medical Genetics and Genomics;   Children's Hospital Medical Center, Cincinnati
  Recruiting
• Identification of L3-L4 Interspace in Parturients

  NCT02697747

  Condition:   Healthy
  Intervention:   Other: Education
  Sponsor:   Beth Israel Deaconess Medical Center
  Recruiting
• Novel Interventions for GWVI

  NCT02661997

  Condition:   Gulf War Veteran's Illness
  Interventions:   Behavioral: Tai Chi Intervention;   Behavioral: Wellness Intervention
  Sponsors:   VA Office of Research and Development;   Boston University;   Tufts Medical Center
  Recruiting
• Whole Exome Sequencing in Finding Causative Variants in Germline DNA Samples From Patients With Peripheral Neuropathy Receiving Paclitaxel for Breast Cancer

  NCT02610439

  Conditions:   Breast Carcinoma;   Neuropathy
  Intervention:   Other: Laboratory Biomarker Analysis
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Whole Exome Sequencing in Finding Causative Variants in Germline DNA Samples From Patients With Congestive Heart Failure Receiving Therapy for Breast Cancer

  NCT02610426

  Conditions:   Breast Carcinoma;   Cardiovascular Complication
  Intervention:   Other: Laboratory Biomarker Analysis
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Whole Exome Sequencing in Finding Causative Variants in Germline DNA Samples From Patients With Hypertension Receiving Bevacizumab for Breast Cancer

  NCT02610413

  Conditions:   Breast Carcinoma;   Hypertension
  Intervention:   Other: Laboratory Biomarker Analysis
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Minimal Residual Disease as a Possible Predictive Factor for Relapse in Patients With AL Amyloidosis

  NCT02555969

  Conditions:   Amyloidosis;   Primary Amyloidosis
  Intervention:  
  Sponsor:   Tufts Medical Center
  Recruiting
• Proton RT for the Treatment of Pediatric Rhabdomyosarcoma

  NCT00592592

  Condition:   Rhabdomyosarcoma
  Intervention:   Radiation: Proton Beam Radiation
  Sponsors:   Massachusetts General Hospital;   M.D. Anderson Cancer Center;   Brigham and Women's Hospital;   Boston Children’s Hospital;   Dana-Farber Cancer Institute;   National Institutes of Health (NIH);   National Cancer Institute (NCI)
  Recruiting
• Using Microbial Genomics to Elucidate the Source of Central-line Associated Bloodstream Infections

  NCT02271243

  Conditions:   Laboratory-confirmed Bloodstream Infection;   Central Line-associated Bloodstream Infections;   Mucosal Barrier Injury
  Intervention:  
  Sponsor:   Boston Children’s Hospital
  Recruiting
• Imaging the Duodenum Using an Optical Frequency Domain Imaging OFDI Capsule

  NCT02202681

  Condition:   Celiac Disease
  Intervention:   Device: OFDI Capsule
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Using Spectrally Encoded Confocal Microscopy (SECM) to Image the Esophagus

  NCT02202590

  Condition:   Eosinophilic Esophagitis
  Intervention:   Device: SECM Capsule
  Sponsors:   Massachusetts General Hospital;   National Institutes of Health (NIH);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
  Recruiting
• Genetic Causes of FSGS, Nephrotic Syndrome, or Kidney Failure

  NCT02194582

  Conditions:   Focal Segmental Glomerulosclerosis;   Nephrotic Syndrome;   End Stage Renal Disease;   Kidney Failure;   Unexplained Proteinuria
  Intervention:  
  Sponsors:   Beth Israel Deaconess Medical Center;   National Institutes of Health (NIH);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   United States Department of Defense
  Recruiting
• Incidence of Difficult Airway and Difficult Neuraxial Placement in Obstetric Patients

  NCT02193542

  Condition:   Indication for Care or Intervention Related to Labor or Delivery With Baby Delivered
  Intervention:  
  Sponsor:   Brigham and Women's Hospital
  Recruiting
• Study to Evaluate the Efficacy of Optical Imaging to Evaluate the Anatomy of the Developing Pediatric Vocal Fold

  NCT01810107

  Condition:   Vocal Fold Development
  Intervention:   Procedure: Children Examined with the OCT Probe
  Sponsor:   Massachusetts Eye and Ear Infirmary
  Recruiting
• TMS for the Investigation of Brain Plasticity in Autism Spectrum Disorders

  NCT02836405

  Conditions:   Autism Spectrum Disorder;   Intellectual Disability
  Intervention:   Device: Transcranial Magnetic Stimulation
  Sponsors:   Boston Children’s Hospital;   Beth Israel Deaconess Medical Center;   National Institute of Mental Health (NIMH)
  Recruiting
• Paroxysmal Nocturnal Hemoglobinuria (PNH) Registry

  NCT01374360

  Condition:   Paroxysmal Nocturnal Hemoglobinuria
  Intervention:  
  Sponsor:   Alexion Pharmaceuticals
  Recruiting
• Investigation of the Genetic Causes of Kallmann Syndrome and Reproductive Disorders

  NCT00494169

  Conditions:   Hypogonadotropic Hypogonadism;   Kallmann Syndrome;   Puberty, Delayed;   Puberty, Precocious;   GnRH Deficiency
  Intervention:  
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Examination of Idiopathic Hypogonadotropic Hypogonadism (IHH)and Kallmann Syndrome (KS)

  NCT00392756

  Conditions:   Kallmann Syndrome;   Hypogonadotropic Hypogonadism;   GnRH Deficiency
  Intervention:   Drug: gonadotropin releasing hormone (GnRH)
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Molecular and Genetic Studies of Congenital Myopathies

  NCT00272883

  Conditions:   Central Core Disease;   Centronuclear Myopathy;   Congenital Fiber Type Disproportion;   Multiminicore Disease;   Myotubular Myopathy;   Nemaline Myopathy;   Rigid Spine Muscular Dystrophy;   Undefined Congenital Myopathy
  Intervention:  
  Sponsors:   Boston Children’s Hospital;   Muscular Dystrophy Association
  Recruiting
• Developing Fast Pediatric Imaging

  NCT03761121

  Condition:   Pediatric Low-grade Gliomas
  Intervention:   Other: Wave-CAIPI
  Sponsors:   Dana-Farber Cancer Institute;   National Institute for Biomedical Imaging and Bioengineering (NIBIB)
  Recruiting
• Reducing the Duration of Untreated Psychosis in the United States

  NCT03369730

  Conditions:   First Episode Psychosis (FEP);   At Risk Mental State (ARMS)
  Intervention:  
  Sponsors:   Icahn School of Medicine at Mount Sinai;   National Institute of Mental Health (NIMH)
  Recruiting
• Natural History Study of Patients With X-linked Retinal Dystrophy Associated With Mutations in Retinitis Pigmentosa GTPase Regulator (RPGR)

  NCT03349242

  Condition:   Retinitis Pigmentosa
  Intervention:  
  Sponsor:   MeiraGTx UK II Ltd
  Recruiting
• A Study to Test the Potential of Brillouin Microscopy for Biomechanical Properties Measurements in Human Cornea

  NCT03220529

  Conditions:   Pellucid Marginal Corneal Degeneration;   Keratoconus;   Keratectasia
  Intervention:   Device: Brillouin Ocular Scanner
  Sponsors:   Massachusetts General Hospital;   Massachusetts Eye and Ear Infirmary
  Recruiting
• Identification of Biomarkers for Patients With Vascular Anomalies

  NCT03001180

  Conditions:   Vascular Anomaly;   Generalized Lymphatic Anomaly;   Kaposiform Hemangioendothelioma;   Kaposiform Lymphangiomatosis;   Gorham-Stout Disease;   Klippel Trenaunay Syndrome;   Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal Nevi
  Intervention:  
  Sponsors:   Children's Hospital Medical Center, Cincinnati;   Lymphangiomatosis and Gorham's Disease Alliance (LGDA);   Boston Children’s Hospital;   Klippel Trenaunay (KT) Support Group;   CLOVES Syndrome Community Support Group
  Recruiting
• Aerobic Exercise for Concussion

  NCT02959216

  Conditions:   Mild Traumatic Brain Injury;   Acute Brain Injury;   Brain Concussion
  Interventions:   Other: Aerobic Exercise;   Other: Stretching Exercise
  Sponsors:   Children's Hospital of Philadelphia;   University at Buffalo;   Boston Children’s Hospital
  Recruiting
• Eltrombopag vs Standard Front Line Management for Newly Diagnosed Immune Thrombocytopenia (ITP) in Children

  NCT03939637

  Condition:   Immune Thrombocytopenia
  Interventions:   Drug: Eltrombopag;   Drug: Steroids;   Drug: IVIG;   Drug: Rho(D) Immune Globulin
  Sponsors:   Baylor College of Medicine;   Boston Children’s Hospital;   University of California, San Francisco
  Recruiting
• Positive Steps to Enhance Problem Solving Skills

  NCT03092531

  Condition:   Adherence
  Intervention:   Behavioral: Positive STEPS
  Sponsor:   Brown University
  Recruiting
• RAD001 and Neurocognition in PTEN Hamartoma Tumor Syndrome

  NCT02991807

  Conditions:   PTEN Gene Mutation;   PTEN Hamartoma Tumor Syndrome
  Interventions:   Drug: RAD001;   Drug: Placebo
  Sponsors:   Boston Children’s Hospital;   National Institutes of Health (NIH);   National Institute of Neurological Disorders and Stroke (NINDS);   Office of Rare Diseases (ORD);   National Center for Advancing Translational Science (NCATS);   Novartis Pharmaceuticals;   PTEN Research;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
  Recruiting
• PAZIT Study for Children and Young Adults With Relapsed or Refractory Sarcoma

  NCT03139331

  Condition:   Sarcoma
  Interventions:   Drug: Pazopanib;   Drug: Irinotecan;   Drug: Temozolomide
  Sponsors:   University of California, San Francisco;   UCSF Benioff Children’s Hospital Oakland;   Dana-Farber Cancer Institute;   Alex's Lemonade Stand Foundation
  Recruiting
• Mindfulness Meditation or Survivorship Education in Improving Behavioral Symptoms in Younger Stage 0-III Breast Cancer Survivors (Pathways to Wellness)

  NCT03025139

  Conditions:   Cancer Survivor;   Early-Stage Breast Carcinoma;   Stage 0 Breast Cancer;   Stage IA Breast Cancer;   Stage IB Breast Cancer;   Stage IIA Breast Cancer;   Stage IIB Breast Cancer;   Stage IIIA Breast Cancer;   Stage IIIB Breast Cancer;   Stage IIIC Breast Cancer
  Interventions:   Other: Educational Intervention;   Other: Laboratory Biomarker Analysis;   Procedure: Meditation Therapy;   Other: Questionnaire Administration
  Sponsors:   Jonsson Comprehensive Cancer Center;   National Cancer Institute (NCI)
  Recruiting
• Early Infant HIV Treatment in Botswana

  NCT02369406

  Conditions:   HIV;   Pediatric AIDS
  Interventions:   Drug: Nevirapine;   Drug: Kaletra;   Drug: Lamivudine;   Drug: Zidovudine
  Sponsors:   Harvard School of Public Health;   Ragon Institute of MGH, MIT and Harvard;   Brigham and Women's Hospital;   University of California, San Diego
  Recruiting
• Gene Therapy for X-linked Retinitis Pigmentosa (XLRP) Retinitis Pigmentosa GTPase Regulator (RPGR)

  NCT03252847

  Condition:   X-Linked Retinitis Pigmentosa
  Intervention:   Genetic: AAV-RPGR
  Sponsors:   MeiraGTx UK II Ltd;   Syne Qua Non Limited;   Bionical-Emas Pharma Ltd
  Recruiting
• A Research Study to Bank Samples for Future Evaluation to Identify Biomarkers That Predispose Crohn's Disease and Ulcerative Colitis Patients to Develop Hepatosplenic T-Cell Lymphoma (HSTCL)

  NCT01804166

  Condition:   Hepatosplenic T-Cell Lymphoma
  Interventions:   Drug: Infliximab;   Drug: Golimumab
  Sponsor:   Janssen Scientific Affairs, LLC
  Recruiting
• Oral ONC201 in Recurrent GBM, H3 K27M Glioma, and Midline Glioma

  NCT02525692

  Conditions:   Glioblastoma;   Diffuse Midline Glioma;   H3 K27M Glioma;   Thalamic Glioma;   Infratentorial Glioma;   Basal Ganglia Glioma
  Intervention:   Drug: ONC201
  Sponsor:   Oncoceutics, Inc.
  Recruiting
• The Videolaryngoscopy in Small Infants

  NCT03396432

  Conditions:   Surgery;   Anesthesia, Endotracheal
  Interventions:   Device: Video Laryngoscopy for ET placement;   Device: Direct Laryngoscopy for ET Placement
  Sponsors:   Children's Hospital of Philadelphia;   Anesthesia Patient Safety Foundation
  Recruiting
• Clinical Study to Assess the Efficacy and Safety of Gene Therapy for the Treatment of Cerebral Adrenoleukodystrophy (CALD)

  NCT03852498

  Condition:   Cerebral Adrenoleukodystrophy (CALD)
  Intervention:   Drug: Genetic
  Sponsor:   bluebird bio
  Recruiting
• Phase I Study of Olaparib and Temozolomide for Ewings Sarcoma

  NCT01858168

  Condition:   Ewing Sarcoma
  Interventions:   Drug: Olaparib;   Drug: Temozolomide;   Drug: Irinotecan
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Response and Biology-Based Risk Factor-Guided Therapy in Treating Younger Patients With Non-high Risk Neuroblastoma

  NCT02176967

  Conditions:   Ganglioneuroblastoma;   Localized Resectable Neuroblastoma;   Localized Unresectable Neuroblastoma;   Neuroblastoma
  Interventions:   Drug: Carboplatin;   Other: Clinical Observation;   Drug: Cyclophosphamide;   Drug: Doxorubicin Hydrochloride;   Drug: Etoposide;   Other: Laboratory Biomarker Analysis;   Other: Pharmacological Study
  Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• Single Ascending Dose Study in Participants With LCA10

  NCT03872479

  Condition:   Leber Congenital Amaurosis 10
  Intervention:   Drug: AGN-151587
  Sponsors:   Allergan;   Editas Medicine, Inc.
  Recruiting
• A Study to Evaluate the Safety, Tolerability, PK, PD, and Clinical Activity of EQ001 in Subjects With aGVHD

  NCT03763318

  Conditions:   Acute-graft-versus-host Disease;   aGVHD;   GVHD;   GVHD, Acute
  Interventions:   Biological: EQ001;   Biological: EQ001 Placebo
  Sponsors:   Equillium;   Biocon Limited
  Recruiting
• Study to Assess the Efficacy and Safety of Umbralisib in Patients With Non-Follicular Indolent Non-Hodgkin's Lymphoma

  NCT03364231

  Condition:   Waldenstrom Macroglobulinemia
  Intervention:   Drug: Umbralisib
  Sponsor:   TG Therapeutics, Inc.
  Recruiting
• Low-Dose Atropine for Treatment of Myopia

  NCT03334253

  Condition:   Myopia
  Interventions:   Drug: Atropine;   Other: Placebo Eyedrops
  Sponsors:   Jaeb Center for Health Research;   Pediatric Eye Disease Investigator Group;   National Eye Institute (NEI)
  Recruiting
• Vedolizumab IV in Pediatric Participants With Ulcerative Colitis (UC) or Crohn's Disease (CD)

  NCT03138655

  Conditions:   Ulcerative Colitis;   Crohn's Disease
  Intervention:   Drug: Vedolizumab
  Sponsor:   Takeda
  Recruiting
• A Study to Evaluate the Pharmacokinetics, Safety, and Efficacy of Glecaprevir/Pibrentasvir in Pediatric Subjects With Genotypes 1-6 Chronic Hepatitis C Virus (HCV) Infection

  NCT03067129

  Condition:   Hepatitis C Virus (HCV)
  Intervention:   Drug: Glecaprevir/Pibrentasvir
  Sponsor:   AbbVie
  Recruiting
• A Study to Investigate the Efficacy and Safety of Balovaptan (RO5285119) in Participants With Autism Spectrum Disorder (ASD)

  NCT02901431

  Condition:   Autism Spectrum Disorder
  Interventions:   Drug: Placebo;   Drug: RO5285119
  Sponsor:   Hoffmann-La Roche
  Recruiting
• Azacitidine and Combination Chemotherapy in Treating Infants With Acute Lymphoblastic Leukemia and KMT2A Gene Rearrangement

  NCT02828358

  Conditions:   Acute Leukemia of Ambiguous Lineage;   B Acute Lymphoblastic Leukemia;   KMT2A Gene Rearrangement;   Mixed Phenotype Acute Leukemia
  Interventions:   Drug: Azacitidine;   Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: Daunorubicin Hydrochloride;   Drug: Dexamethasone;   Drug: Hydrocortisone Sodium Succinate;   Other: Laboratory Biomarker Analysis;   Drug: Leucovorin Calcium;   Drug: Mercaptopurine;   Drug: Methotrexate;   Drug: Pegaspargase;   Other: Pharmacological Study;   Drug: Prednisolone;   Drug: Thioguanine;   Drug: Vincristine Sulfate
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Medication Adherence in Children, Adolescents and Adults With Neurofibromatosis Type 1 (NF1) on Clinical Treatment Trials

  NCT03531814

  Conditions:   Neurofibromatosis 1;   Neurofibroma, Plexiform
  Intervention:   Behavioral: Medication Event Monitoring System (MEMS)
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Response-Based Chemotherapy in Treating Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome in Younger Patients With Down Syndrome

  NCT02521493

  Conditions:   Acute Myeloid Leukemia;   Blasts 5 Percent or More of Bone Marrow Nucleated Cells;   Cytopenia;   Down Syndrome;   Myelodysplastic Syndrome;   Myeloid Leukemia Associated With Down Syndrome;   Myeloproliferative Neoplasm;   Trisomy 21;   Trisomy 21 Mosaicism
  Interventions:   Drug: Asparaginase;   Drug: Asparaginase Erwinia chrysanthemi;   Drug: Cytarabine;   Drug: Daunorubicin Hydrochloride;   Drug: Etoposide;   Other: Laboratory Biomarker Analysis;   Drug: Mitoxantrone Hydrochloride;   Drug: Thioguanine
  Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• Amifampridine Phosphate for the Treatment of Congenital Myasthenic Syndromes

  NCT02562066

  Condition:   Myasthenic Syndromes, Congenital
  Interventions:   Drug: amifampridine phosphate;   Drug: Placebo
  Sponsor:   Catalyst Pharmaceuticals, Inc.
  Recruiting
• Conditioning SCID Infants Diagnosed Early

  NCT03619551

  Condition:   SCID
  Interventions:   Drug: Busulfan;   Device: Cell processing for TCRαβ+/CD19+ depletion
  Sponsor:   Michael Pulsipher, MD
  Recruiting
• Developing e-Health Systems to Improve Growth and Nutrition in CF

  NCT03635762

  Condition:   Cystic Fibrosis in Children
  Intervention:   Behavioral: Be In Charge
  Sponsors:   Boston Children’s Hospital;   Cystic Fibrosis Foundation;   Johns Hopkins University;   Children's Hospital Medical Center, Cincinnati
  Recruiting
• A Study to Evaluate Ketamine for the Treatment of Rett Syndrome

  NCT03633058

  Condition:   Rett Syndrome
  Intervention:   Drug: Ketamine
  Sponsors:   Rett Syndrome Research Trust;   Vanderbilt University Medical Center
  Recruiting
• Ribociclib in Combination With Everolimus and Dexamethasone in Relapsed ALL

  NCT03740334

  Condition:   Acute Lymphoblastic Leukemia ALL
  Interventions:   Drug: Ribociclib;   Drug: Dexamethasone;   Drug: Everolimus
  Sponsors:   Dana-Farber Cancer Institute;   Novartis
  Recruiting
• Cisplatin and Combination Chemotherapy in Treating Children and Young Adults With Hepatoblastoma or Liver Cancer After Surgery

  NCT03533582

  Conditions:   Childhood Hepatocellular Carcinoma;   Childhood Malignant Liver Neoplasm;   Elevated Alpha-Fetoprotein;   Hepatoblastoma;   Hepatocellular Malignant Neoplasm, Not Otherwise Specified;   SMARCB1 Gene Mutation
  Interventions:   Drug: Carboplatin;   Drug: Cisplatin;   Drug: Doxorubicin;   Drug: Etoposide;   Drug: Fluorouracil;   Drug: Gemcitabine;   Drug: Irinotecan;   Other: Laboratory Biomarker Analysis;   Drug: Oxaliplatin;   Other: Patient Observation;   Drug: Sorafenib;   Drug: Vincristine Sulfate
  Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• Iobenguane I-131 or Crizotinib and Standard Therapy in Treating Younger Patients With Newly-Diagnosed High-Risk Neuroblastoma or Ganglioneuroblastoma

  NCT03126916

  Conditions:   Ganglioneuroblastoma;   INRG Stage L2;   INRG Stage M;   INRG Stage MS;   Neuroblastoma;   NMYC Gene Amplification;   Recurrent Neuroblastoma
  Interventions:   Biological: Aldesleukin;   Procedure: Autologous Hematopoietic Stem Cell Transplantation;   Drug: Busulfan;   Drug: Carboplatin;   Drug: Cisplatin;   Drug: Crizotinib;   Drug: Cyclophosphamide;   Drug: Dexrazoxane Hydrochloride;   Biological: Dinutuximab;   Drug: Doxorubicin Hydrochloride;   Drug: Etoposide Phosphate;   Radiation: External Beam Radiation Therapy;   Radiation: Iobenguane I-131;   Drug: Isotretinoin;   Other: Laboratory Biomarker Analysis;   Drug: Melphalan;   Other: Pharmacological Study;   Biological: Sargramostim;   Procedure: Therapeutic Conventional Surgery;   Drug: Thiotepa;   Drug: Topotecan Hydrochloride;   Drug: Vincristine Sulfate
  Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia

  NCT03007147

  Conditions:   B Acute Lymphoblastic Leukemia;   BCR-ABL1 Fusion Protein Expression;   Minimal Residual Disease;   Philadelphia Chromosome Positive;   T Acute Lymphoblastic Leukemia;   Untreated Adult Acute Lymphoblastic Leukemia;   Untreated Childhood Acute Lymphoblastic Leukemia
  Interventions:   Procedure: Allogeneic Hematopoietic Stem Cell Transplantation;   Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: Daunorubicin Hydrochloride;   Drug: Dexamethasone;   Drug: Dexrazoxane Hydrochloride;   Drug: Doxorubicin;   Drug: Etoposide;   Biological: Filgrastim;   Drug: Ifosfamide;   Drug: Imatinib Mesylate;   Other: Laboratory Biomarker Analysis;   Drug: Leucovorin Calcium;   Drug: Mercaptopurine;   Drug: Methotrexate;   Drug: Methylprednisolone;   Drug: Pegaspargase;   Drug: Prednisolone;   Other: Questionnaire Administration;   Drug: Therapeutic Hydrocortisone;   Drug: Thioguanine;   Drug: Vincristine Sulfate
  Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI);   University of Milano Bicocca
  Recruiting
• STRIDE Biorepository

  NCT02843347

  Condition:   Anemia, Sickle Cell
  Intervention:   Procedure: Blood draw
  Sponsors:   Emory University;   National Heart, Lung, and Blood Institute (NHLBI)
  Recruiting
• Reduced Craniospinal Radiation Therapy and Chemotherapy in Treating Younger Patients With Newly Diagnosed WNT-Driven Medulloblastoma

  NCT02724579

  Conditions:   CTNNB1 Gene Mutation;   Medulloblastoma;   Wnt Positive
  Interventions:   Drug: Cisplatin;   Drug: Cyclophosphamide;   Other: Laboratory Biomarker Analysis;   Drug: Lomustine;   Radiation: Radiation Therapy;   Drug: Vincristine;   Drug: Vincristine Sulfate
  Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• Combination Chemotherapy With or Without Temsirolimus in Treating Patients With Intermediate Risk Rhabdomyosarcoma

  NCT02567435

  Conditions:   Alveolar Rhabdomyosarcoma;   Botryoid-Type Embryonal Rhabdomyosarcoma;   Embryonal Rhabdomyosarcoma;   Rhabdomyosarcoma;   Sclerosing Rhabdomyosarcoma;   Spindle Cell Rhabdomyosarcoma;   Untreated Childhood Rhabdomyosarcoma
  Interventions:   Drug: Cyclophosphamide;   Biological: Dactinomycin;   Drug: Irinotecan Hydrochloride;   Other: Laboratory Biomarker Analysis;   Other: Questionnaire Administration;   Radiation: Radiation Therapy;   Drug: Temsirolimus;   Drug: Vincristine Sulfate;   Drug: Vinorelbine
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Project: Every Child for Younger Patients With Cancer

  NCT02402244

  Conditions:   Central Nervous System Neoplasm;   Childhood Immature Teratoma;   Childhood Langerhans Cell Histiocytosis;   Childhood Malignant Neoplasm;   Childhood Mature Teratoma;   Congenital Mesoblastic Nephroma;   Desmoid-Type Fibromatosis;   Lymphoproliferative Disorder;   Myeloproliferative Neoplasm;   Stromal Neoplasm
  Interventions:   Other: Cytology Specimen Collection Procedure;   Other: Medical Chart Review
  Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• Maintenance Chemotherapy or Observation Following Induction Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Ependymoma

  NCT01096368

  Conditions:   Cellular Ependymoma;   Childhood Anaplastic Ependymoma;   Childhood Infratentorial Ependymoma;   Childhood Supratentorial Ependymoma;   Clear Cell Ependymoma;   Ependymoma;   Newly Diagnosed Childhood Ependymoma;   Papillary Ependymoma
  Interventions:   Radiation: 3-Dimensional Conformal Radiation Therapy;   Drug: Carboplatin;   Drug: Cisplatin;   Other: Clinical Observation;   Drug: Cyclophosphamide;   Drug: Etoposide;   Other: Laboratory Biomarker Analysis;   Drug: Vincristine Sulfate Liposome
  Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• Biomarkers in Tumor Tissue Samples From Patients With Newly Diagnosed Neuroblastoma or Ganglioneuroblastoma

  NCT00904241

  Conditions:   Ganglioneuroblastoma;   Localized Resectable Neuroblastoma;   Localized Unresectable Neuroblastoma;   Regional Neuroblastoma;   Stage 4 Neuroblastoma;   Stage 4S Neuroblastoma
  Interventions:   Other: Cytology Specimen Collection Procedure;   Other: Laboratory Biomarker Analysis
  Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• Study of Kidney Tumors in Younger Patients

  NCT00898365

  Conditions:   Clear Cell Sarcoma of the Kidney;   Congenital Mesoblastic Nephroma;   Diffuse Hyperplastic Perilobar Nephroblastomatosis;   Rhabdoid Tumor of the Kidney;   Stage I Kidney Wilms Tumor;   Stage I Renal Cell Cancer AJCC v6 and v7;   Stage II Kidney Wilms Tumor;   Stage II Renal Cell Cancer AJCC v7;   Stage III Kidney Wilms Tumor;   Stage III Renal Cell Cancer AJCC v7;   Stage IV Kidney Wilms Tumor;   Stage IV Renal Cell Cancer AJCC v7;   Stage V Kidney Wilms Tumor
  Interventions:   Other: Cytology Specimen Collection Procedure;   Other: Laboratory Biomarker Analysis
  Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Children and Adolescents

  NCT03020030

  Condition:   Acute Lymphoblastic Leukemia, Pediatric
  Interventions:   Drug: Pegaspargase;   Drug: Erwinia asparaginase;   Drug: Cyclophosphamide;   Drug: CYTARABINE;   Drug: DASATINIB;   Drug: DEXAMETHASONE;   Drug: Dexrazoxane;   Drug: Doxorubicin;   Drug: ETOPOSIDE;   Drug: HYDROCORTISONE;   Drug: LEUCOVORIN CALCIUM;   Drug: MERCAPTOPURINE;   Drug: METHOTREXATE;   Drug: NELARABINE;   Drug: Vincristine
  Sponsors:   Dana-Farber Cancer Institute;   Servier
  Recruiting
• A Multicenter, Open-label, Pilot Study of TAK-935 (OV935) in Participants With 15Q Duplication Syndrome or Cyclin-Dependent Kinase-Like 5 (CDKL5) Deficiency Disorder (ARCADE STUDY)

  NCT03694275

  Conditions:   15q Duplication Syndrome;   CDKL5 Deficiency Disease
  Intervention:   Drug: TAK-935
  Sponsors:   Takeda;   Ovid Therapeutics Inc.
  Recruiting
• Ulixertinib in Treating Patients With Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With MAPK Pathway Mutations (A Pediatric MATCH Treatment Trial)

  NCT03698994

  Conditions:   Advanced Malignant Solid Neoplasm;   ARAF Gene Mutation;   BRAF Gene Mutation;   GNA11 Gene Mutation;   GNAQ Gene Mutation;   HRAS Gene Mutation;   KRAS Gene Mutation;   MAP2K1 Gene Mutation;   MAPK1 Gene Mutation;   NF1 Gene Mutation;   NRAS Gene Mutation;   Recurrent Ependymal Tumor;   Recurrent Ewing Sarcoma;   Recurrent Glioma;   Recurrent Hepatoblastoma;   Recurrent Histiocytic and Dendritic Cell Neoplasm;   Recurrent Langerhans Cell Histiocytosis;   Recurrent Malignant Central Nervous System Neoplasm;   Recurrent Malignant Germ Cell Tumor;   Recurrent Malignant Solid Neoplasm;   Recurrent Medulloblastoma;   Recurrent Neuroblastoma;   Recurrent Non-Hodgkin Lymphoma;   Recurrent Osteosarcoma;   Recurrent Peripheral Primitive Neuroectodermal Tumor;   Recurrent Rhabdoid Tumor;   Recurrent Rhabdomyosarcoma;   Recurrent Soft Tissue Sarcoma;   Refractory Ependymoma;   Refractory Ewing Sarcoma;   Refractory Glioma;   Refractory Hepatoblastoma;   Refractory Histiocytic and Dendritic Cell Neoplasm;   Refractory Langerhans Cell Histiocytosis;   Refractory Malignant Central Nervous System Neoplasm;   Refractory Malignant Germ Cell Tumor;   Refractory Malignant Solid Neoplasm;   Refractory Medulloblastoma;   Refractory Neuroblastoma;   Refractory Non-Hodgkin Lymphoma;   Refractory Osteosarcoma;   Refractory Peripheral Primitive Neuroectodermal Tumor;   Refractory Rhabdoid Tumor;   Refractory Rhabdomyosarcoma;   Refractory Soft Tissue Sarcoma;   Wilms Tumor
  Interventions:   Other: Pharmacokinetic Study;   Drug: Ulixertinib
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Veliparib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Malignant Glioma Without H3 K27M or BRAFV600 Mutations

  NCT03581292

  Conditions:   Anaplastic Astrocytoma;   BRAF V600 Wild Type;   Glioblastoma;   H3 K27M Negative;   Malignant Glioma
  Interventions:   Radiation: Radiation Therapy;   Drug: Temozolomide;   Drug: Veliparib
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Palbociclib in Treating Patients With Relapsed or Refractory Rb Positive Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Activating Alterations in Cell Cycle Genes (A Pediatric MATCH Treatment Trial)

  NCT03526250

  Conditions:   Advanced Malignant Solid Neoplasm;   RB1 Positive;   Recurrent Childhood Ependymoma;   Recurrent Ewing Sarcoma;   Recurrent Glioma;   Recurrent Hepatoblastoma;   Recurrent Kidney Wilms Tumor;   Recurrent Langerhans Cell Histiocytosis;   Recurrent Malignant Germ Cell Tumor;   Recurrent Malignant Glioma;   Recurrent Medulloblastoma;   Recurrent Neuroblastoma;   Recurrent Non-Hodgkin Lymphoma;   Recurrent Osteosarcoma;   Recurrent Peripheral Primitive Neuroectodermal Tumor;   Recurrent Rhabdoid Tumor;   Recurrent Rhabdomyosarcoma;   Recurrent Soft Tissue Sarcoma;   Refractory Ependymoma;   Refractory Ewing Sarcoma;   Refractory Glioma;   Refractory Hepatoblastoma;   Refractory Langerhans Cell Histiocytosis;   Refractory Malignant Germ Cell Tumor;   Refractory Malignant Glioma;   Refractory Medulloblastoma;   Refractory Neuroblastoma;   Refractory Non-Hodgkin Lymphoma;   Refractory Osteosarcoma;   Refractory Peripheral Primitive Neuroectodermal Tumor;   Refractory Rhabdoid Tumor;   Refractory Rhabdomyosarcoma;   Refractory Soft Tissue Sarcoma
  Interventions:   Other: Laboratory Biomarker Analysis;   Drug: Palbociclib;   Other: Pharmacological Study
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Vemurafenib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With BRAF V600 Mutations (A Pediatric MATCH Treatment Trial)

  NCT03220035

  Conditions:   Advanced Malignant Solid Neoplasm;   Ann Arbor Stage III Childhood Non-Hodgkin Lymphoma;   Ann Arbor Stage IV Childhood Non-Hodgkin Lymphoma;   BRAF NP_004324.2:p.V600X;   Ependymoma;   Ewing Sarcoma;   Hepatoblastoma;   Langerhans Cell Histiocytosis;   Malignant Germ Cell Tumor;   Malignant Glioma;   Osteosarcoma;   Peripheral Primitive Neuroectodermal Tumor;   Recurrent Childhood Central Nervous System Neoplasm;   Recurrent Childhood Non-Hodgkin Lymphoma;   Recurrent Malignant Solid Neoplasm;   Recurrent Neuroblastoma;   Refractory Central Nervous System Neoplasm;   Refractory Malignant Solid Neoplasm;   Refractory Neuroblastoma;   Refractory Non-Hodgkin Lymphoma;   Rhabdoid Tumor;   Rhabdomyosarcoma;   Soft Tissue Sarcoma;   Wilms Tumor
  Interventions:   Other: Laboratory Biomarker Analysis;   Drug: Vemurafenib
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• PI3K/mTOR Inhibitor LY3023414 in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With TSC or PI3K/MTOR Mutations (A Pediatric MATCH Treatment Trial)

  NCT03213678

  Conditions:   Advanced Malignant Solid Neoplasm;   Ann Arbor Stage III Non-Hodgkin Lymphoma;   Ann Arbor Stage IV Non-Hodgkin Lymphoma;   Malignant Glioma;   Recurrent Central Nervous System Neoplasm;   Recurrent Ependymoma;   Recurrent Ewing Sarcoma;   Recurrent Glioma;   Recurrent Hepatoblastoma;   Recurrent Langerhans Cell Histiocytosis;   Recurrent Malignant Germ Cell Tumor;   Recurrent Malignant Solid Neoplasm;   Recurrent Medulloblastoma;   Recurrent Neuroblastoma;   Recurrent Non-Hodgkin Lymphoma;   Recurrent Osteosarcoma;   Recurrent Peripheral Primitive Neuroectodermal Tumor;   Recurrent Rhabdomyosarcoma;   Recurrent Soft Tissue Sarcoma;   Refractory Central Nervous System Neoplasm;   Refractory Langerhans Cell Histiocytosis;   Refractory Malignant Germ Cell Tumor;   Refractory Malignant Solid Neoplasm;   Refractory Neuroblastoma;   Refractory Non-Hodgkin Lymphoma;   Rhabdoid Tumor;   Stage III Osteosarcoma AJCC v7;   Stage III Soft Tissue Sarcoma AJCC v7;   Stage IV Osteosarcoma AJCC v7;   Stage IV Soft Tissue Sarcoma AJCC v7;   Stage IVA Osteosarcoma AJCC v7;   Stage IVB Osteosarcoma AJCC v7;   TSC1 Gene Mutation;   TSC2 Gene Mutation;   Wilms Tumor
  Interventions:   Other: Laboratory Biomarker Analysis;   Other: Pharmacological Study;   Drug: Samotolisib
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Ensartinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With ALK or ROS1 Genomic Alterations (A Pediatric MATCH Treatment Trial)

  NCT03213652

  Conditions:   Advanced Malignant Solid Neoplasm;   ALK Fusion Protein Expression;   ALK Gene Mutation;   ALK Gene Translocation;   Ann Arbor Stage III Childhood Non-Hodgkin Lymphoma;   Ann Arbor Stage IV Childhood Non-Hodgkin Lymphoma;   Histiocytosis;   Recurrent Childhood Central Nervous System Neoplasm;   Recurrent Childhood Non-Hodgkin Lymphoma;   Recurrent Malignant Solid Neoplasm;   Recurrent Neuroblastoma;   Refractory Central Nervous System Neoplasm;   Refractory Malignant Solid Neoplasm;   Refractory Neuroblastoma;   Refractory Non-Hodgkin Lymphoma;   ROS1 Fusion Positive;   ROS1 Gene Mutation;   ROS1 Gene Translocation
  Interventions:   Drug: Ensartinib;   Other: Laboratory Biomarker Analysis;   Other: Pharmacological Study
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)

  NCT03155620

  Conditions:   Advanced Malignant Solid Neoplasm;   Ann Arbor Stage III Childhood Non-Hodgkin Lymphoma;   Ann Arbor Stage IV Childhood Non-Hodgkin Lymphoma;   Childhood Langerhans Cell Histiocytosis;   Histiocytic Sarcoma;   Juvenile Xanthogranuloma;   Malignant Glioma;   Recurrent Central Nervous System Neoplasm;   Recurrent Childhood Ependymoma;   Recurrent Childhood Malignant Germ Cell Tumor;   Recurrent Childhood Medulloblastoma;   Recurrent Childhood Non-Hodgkin Lymphoma;   Recurrent Childhood Rhabdomyosarcoma;   Recurrent Childhood Soft Tissue Sarcoma;   Recurrent Ewing Sarcoma;   Recurrent Glioma;   Recurrent Hepatoblastoma;   Recurrent Langerhans Cell Histiocytosis;   Recurrent Malignant Solid Neoplasm;   Recurrent Neuroblastoma;   Recurrent Osteosarcoma;   Recurrent Peripheral Primitive Neuroectodermal Tumor;   Recurrent Rhabdoid Tumor;   Refractory Central Nervous System Neoplasm;   Refractory Childhood Malignant Germ Cell Tumor;   Refractory Ewing Sarcoma;   Refractory Glioma;   Refractory Hepatoblastoma;   Refractory Langerhans Cell Histiocytosis;   Refractory Malignant Solid Neoplasm;   Refractory Medulloblastoma;   Refractory Neuroblastoma;   Refractory Non-Hodgkin Lymphoma;   Refractory Osteosarcoma;   Refractory Peripheral Primitive Neuroectodermal Tumor;   Refractory Rhabdoid Tumor;   Refractory Rhabdomyosarcoma;   Rhabdoid Tumor;   Stage III Osteosarcoma AJCC v7;   Stage III Soft Tissue Sarcoma AJCC v7;   Stage IV Osteosarcoma AJCC v7;   Stage IV Soft Tissue Sarcoma AJCC v7;   Stage IVA Osteosarcoma AJCC v7;   Stage IVB Osteosarcoma AJCC v7;   Wilms Tumor
  Interventions:   Procedure: Biopsy;   Procedure: Biospecimen Collection;   Drug: Ensartinib;   Drug: Erdafitinib;   Other: Laboratory Biomarker Analysis;   Drug: Larotrectinib;   Procedure: Mutation Carrier Screening;   Drug: Olaparib;   Drug: Palbociclib;   Other: Pharmacological Study;   Drug: Samotolisib;   Drug: Selumetinib Sulfate;   Drug: Tazemetostat;   Drug: Ulixertinib;   Drug: Vemurafenib
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors

  NCT03067181

  Conditions:   Adult Germ Cell Tumor;   Childhood Extracranial Germ Cell Tumor;   Childhood Germ Cell Tumor;   Extragonadal Embryonal Carcinoma;   Grade 2 Ovarian Teratoma;   Malignant Germ Cell Tumor;   Malignant Ovarian Teratoma;   Stage I Ovarian Choriocarcinoma;   Stage I Ovarian Embryonal Carcinoma AJCC v6 and v7;   Stage I Ovarian Teratoma AJCC v6 and v7;   Stage I Ovarian Yolk Sac Tumor AJCC v6 and v7;   Stage I Testicular Choriocarcinoma AJCC v6 and v7;   Stage I Testicular Embryonal Carcinoma AJCC v6 and v7;   Stage I Testicular Yolk Sac Tumor AJCC v6 and v7;   Stage II Ovarian Choriocarcinoma;   Stage II Ovarian Embryonal Carcinoma AJCC v6 and v7;   Stage II Ovarian Yolk Sac Tumor AJCC v6 and v7;   Stage II Testicular Choriocarcinoma AJCC v6 and v7;   Stage II Testicular Embryonal Carcinoma AJCC v6 and v7;   Stage II Testicular Yolk Sac Tumor AJCC v6 and v7;   Stage III Ovarian Choriocarcinoma;   Stage III Ovarian Embryonal Carcinoma AJCC v6 and v7;   Stage III Ovarian Yolk Sac Tumor AJCC v6 and v7;   Stage III Testicular Choriocarcinoma AJCC v6 and v7;   Stage III Testicular Embryonal Carcinoma AJCC v6 and v7;   Stage III Testicular Yolk Sac Tumor AJCC v6 and v7;   Stage IV Ovarian Choriocarcinoma;   Stage IV Ovarian Embryonal Carcinoma AJCC v6 and v7;   Stage IV Ovarian Yolk Sac Tumor AJCC v6 and v7;   Testicular Mixed Choriocarcinoma and Embryonal Carcinoma;   Testicular Mixed Choriocarcinoma and Teratoma;   Testicular Mixed Choriocarcinoma and Yolk Sac Tumor
  Interventions:   Other: Best Practice;   Drug: Bleomycin;   Biological: Bleomycin Sulfate;   Drug: Carboplatin;   Drug: Cisplatin;   Drug: Etoposide;   Drug: Etoposide Phosphate;   Other: Laboratory Biomarker Analysis;   Other: Pharmacogenomic Study;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration
  Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• Late Effects After Treatment in Patients With Previously Diagnosed High-Risk Neuroblastoma

  NCT03057626

  Conditions:   Recurrent Neuroblastoma;   Stage 2A Neuroblastoma;   Stage 2B Neuroblastoma;   Stage 3 Neuroblastoma;   Stage 4 Neuroblastoma;   Stage 4S Neuroblastoma
  Interventions:   Other: Cytology Specimen Collection Procedure;   Other: Laboratory Biomarker Analysis;   Other: Quality-of-Life Assessment
  Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• Cabozantinib-S-Malate in Treating Younger Patients With Recurrent, Refractory, or Newly Diagnosed Sarcomas, Wilms Tumor, or Other Rare Tumors

  NCT02867592

  Conditions:   Adrenal Cortex Carcinoma;   Alveolar Soft Part Sarcoma;   Central Nervous System Neoplasm;   Childhood Clear Cell Sarcoma of Soft Parts;   Clear Cell Sarcoma of Soft Tissue;   Ewing Sarcoma;   Hepatoblastoma;   Hepatocellular Carcinoma;   MITF Positive;   Osteosarcoma;   Recurrent Adrenal Cortex Carcinoma;   Recurrent Alveolar Soft Part Sarcoma;   Recurrent Ewing Sarcoma;   Recurrent Hepatoblastoma;   Recurrent Hepatocellular Carcinoma;   Recurrent Malignant Central Nervous System Neoplasm;   Recurrent Malignant Solid Neoplasm;   Recurrent Osteosarcoma;   Recurrent Renal Cell Carcinoma;   Recurrent Rhabdomyosarcoma;   Recurrent Soft Tissue Sarcoma;   Recurrent Soft Tissue Sarcoma, Excluding Rhabdomyosarcoma;   Recurrent Thyroid Gland Medullary Carcinoma;   Refractory Ewing Sarcoma;   Refractory Malignant Central Nervous System Neoplasm;   Refractory Malignant Solid Neoplasm;   Refractory Osteosarcoma;   Refractory Rhabdomyosarcoma;   Refractory Soft Tissue Sarcoma;   Refractory Soft Tissue Sarcoma, Excluding Rhabdomyosarcoma;   Renal Cell Carcinoma;   Rhabdomyosarcoma;   Soft Tissue Sarcoma, Excluding Rhabdomyosarcoma;   Solid Neoplasm;   Thyroid Gland Medullary Carcinoma;   Wilms Tumor
  Interventions:   Drug: Cabozantinib;   Drug: Cabozantinib S-malate;   Other: Pharmacological Study
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Low Dose Oral Methotrexate in Pediatric Crohn's Disease Patients Initiating Anti-Tumor Necrosis Factor (Anti-TNF) Therapy

  NCT02772965

  Condition:   Pediatric Crohn's Disease
  Interventions:   Drug: Methotrexate;   Other: Sugar pill (placebo)
  Sponsors:   University of North Carolina, Chapel Hill;   Patient-Centered Outcomes Research Institute;   ImproveCareNow (ICN);   The Leona M. and Harry B. Helmsley Charitable Trust;   Children's Hospital Medical Center, Cincinnati;   Grifols Diagnostics Solutions, Inc;   National Institutes of Health (NIH);   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
  Recruiting
• A Phase 1 Study of the EZH2 Inhibitor Tazemetostat in Pediatric Subjects With Relapsed or Refractory INI1-Negative Tumors or Synovial Sarcoma

  NCT02601937

  Conditions:   Rhabdoid Tumors;   INI1-negative Tumors;   Synovial Sarcoma;   Malignant Rhabdoid Tumor of Ovary
  Intervention:   Drug: Tazemetostat
  Sponsor:   Epizyme, Inc.
  Recruiting
• Pediatric Femur Fracture Registry

  NCT03211546

  Condition:   Femoral Shaft Fracture
  Interventions:   Procedure: Conservative (non-surgical) treatment;   Procedure: Surgical treatment
  Sponsor:   AO Clinical Investigation and Documentation
  Recruiting
• Pediatric Adenotonsillectomy Trial for Snoring

  NCT02562040

  Condition:   Sleep-Disordered Breathing
  Interventions:   Procedure: Early Adenotonsillectomy (eAT);   Behavioral: Watchful Waiting with Supportive Care (WWSC)
  Sponsors:   Brigham and Women's Hospital;   Children's Hospital of Philadelphia;   University Hospitals Cleveland Medical Center;   Children's Hospital Medical Center, Cincinnati;   University of Michigan;   University of Texas Southwestern Medical Center;   University of Rochester;   Children's Hospital of The King's Daughters;   Boston Children’s Hospital
  Recruiting
• Durvalumab and Tremelimumab for Pediatric Malignancies

  NCT03837899

  Conditions:   Pediatric Cancer;   Solid Tumor Pediatric;   Hematological Malignancies
  Intervention:   Drug: Durvalumab / Tremelimumab Combination Therapy
  Sponsor:   AstraZeneca
  Recruiting
• Riociguat in Children With Pulmonary Arterial Hypertension (PAH)

  NCT02562235

  Condition:   Hypertension, Pulmonary
  Intervention:   Drug: Riociguat (Adempas, BAY63-2521)
  Sponsors:   Bayer;   Merck Sharp & Dohme Corp.
  Recruiting
• Observational Study Investigating Clinical & Anthropometric Characteristics of Children With Achondroplasia.

  NCT03794609

  Condition:   Achondroplasia
  Intervention:  
  Sponsor:   Therachon SAS
  Recruiting
• A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Upadacitinib in Pediatric Subjects With Polyarticular Course Juvenile Idiopathic Arthritis

  NCT03725007

  Condition:   Juvenile Idiopathic Arthritis (JIA)
  Intervention:   Drug: Upadacitinib
  Sponsor:   AbbVie
  Recruiting
• Flourish™ Pediatric Esophageal Atresia

  NCT03615495

  Conditions:   Esophageal Atresia;   Digestive System Abnormalities;   Esophageal Disorders Congenital
  Intervention:   Device: Flourish Pediatric Esphogeal Atresia device
  Sponsor:   Cook Research Incorporated
  Recruiting
• Intranasal Dexmedetomidine Sedation in Children for Non-painful Procedures

  NCT03220880

  Conditions:   Dexmedetomidine;   Sedation
  Intervention:   Drug: Intranasal dexmedetomidine
  Sponsors:   Columbia University;   Children's Healthcare of Atlanta;   University of Pittsburgh;   Children's Hospital Medical Center, Cincinnati;   Dartmouth College;   Duke University;   Santa Clara Valley Medical Center;   Texas Children's Hospital;   UNC Children's Hospital;   Boston Children’s Hospital
  Recruiting
• Different Therapies in Treating Infants With Newly Diagnosed Acute Leukemia

  NCT00550992

  Condition:   Leukemia
  Interventions:   Biological: anti-thymocyte globulin;   Drug: asparaginase;   Drug: busulfan;   Drug: cyclophosphamide;   Drug: cyclosporine;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: etoposide;   Drug: leucovorin calcium;   Drug: melphalan;   Drug: mercaptopurine;   Drug: methotrexate;   Drug: mitoxantrone hydrochloride;   Drug: pegaspargase;   Drug: prednisolone;   Drug: prednisone;   Drug: therapeutic hydrocortisone;   Drug: thioguanine;   Drug: vincristine sulfate;   Procedure: allogeneic bone marrow transplantation;   Procedure: allogeneic hematopoietic stem cell transplantation;   Procedure: umbilical cord blood transplantation
  Sponsors:   Dutch Childhood Oncology Group;   BFM Germany;   CORS Monza Italy;   Associazione Italiana Ematologia Oncologia Pediatrica;   Australian and New Zealand Children's Oncology Group;   BFM Austria;   CLCG France Belgium Portugal;   COALL Germany;   CPH, Czech republic;   DFCI consortium USA;   FRALLE France;   Hong Kong;   MD Anderson USA;   NOPHO Scandinavian countries;   PINDA, Chile;   PPLLSG Poland;   Seattle USA;   SJCRH USA;   UKCCSG United Kingdom
  Recruiting
• CMV T Cell Immunity in Pediatric Solid Organ Transplant Recipients

  NCT03924219

  Conditions:   Heart Transplant Infection;   Kidney Transplant Infection;   Liver Transplant Infection;   CMV
  Intervention:   Other: CMV T cell Immunity Assay
  Sponsors:   Vanderbilt University Medical Center;   ViraCor Laboratories
  Recruiting
• A Study to Evaluate Safety, Tolerability and Immune Response in Adolescents Allergic to Peanut After Receiving Intradermal Administration of ASP0892 (ARA-LAMP-vax), a Single Multivalent Peanut (Ara h1, h2, h3) Lysosomal Associated Membrane Protein DNA Plasmid Vaccine

  NCT03755713

  Condition:   Peanut Allergy
  Interventions:   Drug: ASP0892;   Drug: Placebo
  Sponsor:   Astellas Pharma Global Development, Inc.
  Recruiting
• A Safety and PK Study of IV Eravacycline

  NCT03696550

  Condition:   Bacterial Infections
  Intervention:   Drug: Eravacycline (TP-434)
  Sponsor:   Tetraphase Pharmaceuticals, Inc.
  Recruiting
• Observational Study to Evaluate Allogeneic HSCT Outcomes for Cerebral Adrenoleukodystrophy (CALD)

  NCT02204904

  Conditions:   X-Linked Adrenoleukodystrophy (X-ALD);   Cerebral Adrenoleukodystrophy (CALD);   Adrenoleukodystrophy (ALD)
  Intervention:   Genetic: Allo-HSCT
  Sponsor:   bluebird bio
  Recruiting
• Elbasvir (EBR)/Grazoprevir (GZR) in Pediatric Participants With Chronic Hepatitis C Infection (MK-5172-079)

  NCT03379506

  Condition:   HCV Infection
  Intervention:   Drug: EBR/GZR
  Sponsor:   Merck Sharp & Dohme Corp.
  Recruiting
• Evaluating the Pharmacokinetics, Safety, and Tolerability of Doravirine (MK-1439) and Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate (MK-1439A) in HIV-1-Infected Children and Adolescents

  NCT03332095

  Condition:   HIV Infections
  Interventions:   Drug: Doravirine (DOR);   Drug: Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate (DOR/3TC/TDF);   Drug: Antiretroviral (ARV) medications
  Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
  Recruiting
• Intermittent Hypoxia and Caffeine in Infants Born Preterm

  NCT03321734

  Condition:   Intermittent Hypoxia
  Interventions:   Drug: Caffeine;   Drug: Placebos
  Sponsors:   Children's Research Institute;   Boston University;   Beth Israel Medical Center;   University of Massachusetts, Worcester;   American SIDS Institute;   Walter Reed National Military Medical Center;   Dartmouth-Hitchcock Medical Center;   Children's Hospital of Philadelphia;   Johns Hopkins All Children's Hospital;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
  Recruiting
• A Study of Oral LOXO-292 in Pediatric Patients With Advanced Solid or Primary Central Nervous System Tumors

  NCT03899792

  Conditions:   Medullary Thyroid Cancer;   Infantile Myofibromatosis;   Infantile Fibrosarcoma;   Papillary Thyroid Cancer;   Soft Tissue Sarcoma
  Intervention:   Drug: LOXO-292
  Sponsor:   Loxo Oncology, Inc.
  Recruiting
• Therapeutic Use of Tadekinig Alfa in NLRC4 Mutation and XIAP Deficiency

  NCT03113760

  Conditions:   NLRC4-MAS;   XIAP Deficiency
  Interventions:   Drug: Tadekinig alfa;   Other: 0.9% sodium chloride
  Sponsor:   AB2 Bio Ltd.
  Recruiting
• Efficacy, Safety and Pharmacokinetics of Topical Timolol in Infants With Infantile Hemangioma (IH)

  NCT02913612

  Condition:   Infantile Hemangioma
  Interventions:   Drug: 0.25% Timolol Maleate Gel Forming Solution;   Drug: 0.5% Timolol Maleate Gel Forming Solution
  Sponsors:   Chiara Melloni;   The Emmes Company, LLC;   National Institutes of Health (NIH)
  Recruiting
• Pediatric ACL: Understanding Treatment Options

  NCT02772770

  Condition:   Anterior Cruciate Ligament Reconstruction
  Interventions:   Other: Non-operative treatment group will undergo standardized treatment which will include rehabilitation, bracing and certain activity restrictions;   Procedure: Surgical technique: Transphyseal reconstruction;   Procedure: Surgical technique: Partial transphyseal reconstruction;   Procedure: Surgical technique: Physeal sparing reconstruction by the Anderson method;   Procedure: Surgical technique: Physeal sparing reconstruction by the Micheli/Kocher method
  Sponsors:   Boston Children’s Hospital;   Children's Hospital of Philadelphia;   Children's Hospital Medical Center, Cincinnati;   Rady Children's Hospital, San Diego;   Washington University School of Medicine;   Children's Healthcare of Atlanta;   The Cleveland Clinic;   Tennessee Orthopedic Alliance;   Hospital for Special Surgery, New York;   Stanford University
  Recruiting
• A Multi-center, Longitudinal, Observational Study of Children With Achondroplasia

  NCT03875534

  Condition:   Achondroplasia
  Intervention:  
  Sponsor:   Ascendis Pharma A/S
  Recruiting
• Cockroach Immunotherapy in Children and Adolescents

  NCT03541187

  Condition:   Persistent Asthma
  Interventions:   Biological: German cockroach allergenic extract;   Biological: Placebo for German cockroach allergenic extract
  Sponsors:   National Institute of Allergy and Infectious Diseases (NIAID);   Inner-City Asthma Consortium
  Recruiting
• MK-7625A Plus Metronidazole Versus Meropenem in Pediatric Participants With Complicated Intra-Abdominal Infection (cIAI) (MK-7625A-035)

  NCT03217136

  Condition:   Complicated Intra-Abdominal Infection
  Interventions:   Drug: Ceftolozane;   Drug: Tazobactam;   Drug: Metronidazole;   Drug: Meropenem;   Drug: Placebo for Metronidazole
  Sponsor:   Merck Sharp & Dohme Corp.
  Recruiting
• Safety and Immunogenicity of a Single Dose of the Recombinant Live-Attenuated Respiratory Syncytial Virus (RSV) Vaccines RSV ΔNS2/Δ1313/I1314L, RSV 6120/ΔNS2/1030s, RSV 276 or Placebo, Delivered as Nose Drops to RSV-Seronegative Children 6 to 24 Months of Age

  NCT03916185

  Condition:   Respiratory Syncytial Virus (RSV)
  Interventions:   Biological: RSV ΔNS2/Δ1313/I1314L Vaccine;   Biological: RSV 6120/ΔNS2/1030s Vaccine;   Biological: RSV 276 Vaccine;   Biological: Placebo
  Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
  Recruiting
• Study to Investigate Safety, Pharmacokinetic (PK), Pharmacodynamic (PD) and Clinical Activity of Trametinib in Subjects With Cancer or Plexiform Neurofibromas and Trametinib in Combination With Dabrafenib in Subjects With Cancers Harboring V600 Mutations

  NCT02124772

  Condition:   Cancer
  Interventions:   Drug: Trametinib;   Drug: Dabrafenib
  Sponsor:   Novartis Pharmaceuticals
  Recruiting
• A Study to Evaluate the Safety and Efficacy of MEDI8897 for the Prevention of Medically Attended RSV LRTI in Healthy Late Preterm and Term Infants

  NCT03979313

  Condition:   Respiratory Syncytial Virus Infections
  Interventions:   Drug: MEDI8897;   Drug: Placebo
  Sponsor:   MedImmune LLC
  Recruiting
• A Study to Evaluate the Safety of MEDI8897 for the Prevention of Medically Attended Respiratory Syncytial Virus(RSV) Lower Respiratory Track Infection (LRTI) in High-risk Children

  NCT03959488

  Condition:   Respiratory Syncytial Virus Infections
  Interventions:   Drug: MEDI8897;   Drug: Palivizumab
  Sponsor:   MedImmune LLC
  Recruiting
• Pre-Symptomatic Study of Intravenous Onasemnogene Abeparvovec-xioi in Spinal Muscular Atrophy (SMA) for Patients With Multiple Copies of SMN2

  NCT03505099

  Condition:   Spinal Muscular Atrophy
  Intervention:   Biological: onasemnogene abeparvovec-xioi
  Sponsors:   AveXis, Inc.;   PRA Health Sciences
  Recruiting
• Study of Dose Confirmation and Safety of Crizanlizumab in Pediatric Sickle Cell Disease Patients

  NCT03474965

  Condition:   Sickle Cell Disease
  Intervention:   Drug: Crizanlizumab
  Sponsor:   Novartis Pharmaceuticals
  Recruiting
• Patient Perception of Treatment Burden in Weekly Versus Daily Growth Hormone Injections in Children With GHD

  NCT03831880

  Condition:   Growth Hormone Deficiency
  Interventions:   Drug: Genotropin;   Drug: somatrogon
  Sponsor:   Pfizer
  Recruiting
• ATHN 8: PUPs Matter Study

  NCT03818529

  Conditions:   Hemophilia;   Hemophilia A;   Hemophilia B;   Hemophilia A With Inhibitor;   Hemophilia B With Inhibitor;   Haemophilia B Without Inhibitor;   Haemophilia A Without Inhibitor;   Haemophilia
  Intervention:  
  Sponsors:   American Thrombosis and Hemostasis Network;   CSL Behring;   Octapharma;   Takeda
  Recruiting
• Study of Intrathecal Administration of Onasemnogene Abeparvovec-xioi for Spinal Muscular Atrophy

  NCT03381729

  Condition:   Spinal Muscular Atrophy
  Intervention:   Biological: Onasemnogene Abeparvovec-xioi
  Sponsor:   AveXis, Inc.
  Recruiting
• A Study Comparing LY900014 to Insulin Lispro (Humalog) in Children and Adolescents With Type 1 Diabetes

  NCT03740919

  Condition:   Type 1 Diabetes Mellitus
  Interventions:   Drug: LY900014;   Drug: Insulin Lispro
  Sponsor:   Eli Lilly and Company
  Recruiting
• Phase III Study of Edasalonexent in Boys With Duchenne Muscular Dystrophy

  NCT03703882

  Condition:   Muscular Dystrophy, Duchenne
  Interventions:   Drug: Edasalonexent;   Drug: Placebo
  Sponsor:   Catabasis Pharmaceuticals
  Recruiting
• A Study to Evaluate Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics of Leuprolide Acetate 45mg 6-Month Formulation in Children With Central Precocious Puberty (CPP)

  NCT03695237

  Condition:   Central Precocious Puberty (CPP)
  Intervention:   Drug: Leuprolide Acetate (LA)
  Sponsor:   AbbVie
  Recruiting
• Study in Pediatric Subjects With Peanut Allergy to Evaluate Efficacy and Safety of Dupilumab as Adjunct to AR101 (Peanut Oral Immunotherapy)

  NCT03682770

  Condition:   Peanut Allergy
  Interventions:   Drug: Dupilumab;   Drug: Placebo matching dupilumab;   Drug: AR101
  Sponsors:   Regeneron Pharmaceuticals;   Sanofi;   Aimmune Therapeutics, Inc.
  Recruiting