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• Routine Versus no Assessment of Gastric Residual Volumes in Preterm Infants

  NCT04062851

  Conditions:   Gastric Residual Volume;   Preterm Infant;   Feeding Disorder Neonatal
  Intervention:   Other: No Gastric residual volume monitoring
  Sponsor:   Florida Hospital
  Recruiting
• Evaluation of the Spark of Duval Intervention

  NCT04044027

  Condition:   Teen Pregnancy Prevention
  Intervention:   Behavioral: S.P.A.R.K (Speaking to the Potential, Ability and Resilience inside Kids) Teen Pregnancy Prevention and Mentoring
  Sponsor:   University of South Florida
  Recruiting
• Addition of Acetaminophen in Standard PDA Management

  NCT04026464

  Condition:   Patent Ductus Arteriosus
  Interventions:   Drug: Intravenous Ibuprofen;   Drug: Intravenous Ibuprofen + Oral Acetaminophen
  Sponsor:   University of Florida
  Not yet recruiting
• Skeletal Muscle Effects of GH in Boys

  NCT04020913

  Conditions:   Growth Hormone Deficiency;   Idiopathic Short Stature
  Intervention:   Drug: Somatropin injection
  Sponsors:   Nemours Children's Clinic;   Novo Nordisk A/S
  Recruiting
• MCRF Clinical Pilot Study

  NCT03991585

  Condition:   Emotional Adjustment
  Intervention:   Behavioral: Musical Contour Regulation Facilitation (MCRF)
  Sponsors:   University of Miami;   American Music Therapy Association;   University of Kansas
  Recruiting
• Screening for Autism Spectrum Disorders Using Auditory Brainstem Responses

  NCT03971578

  Condition:   Autism Spectrum Disorder
  Intervention:   Other: No Intervention Provided
  Sponsors:   Intelligent Hearing Systems;   National Institute on Deafness and Other Communication Disorders (NIDCD)
  Not yet recruiting
• Reducing Obesity Health Disparities in Hispanic Youth

  NCT03943628

  Conditions:   Overweight;   Family Relations;   Adolescent Behavior;   Drug Use;   Sexual Behavior
  Intervention:   Behavioral: Familias Unidas
  Sponsors:   University of Miami;   National Institutes of Health (NIH);   National Institute on Minority Health and Health Disparities (NIMHD)
  Active, not recruiting
• The FOUNDATION Study

  NCT03939546

  Condition:   Preterm Infant
  Intervention:   Other: B. infantis EVC001
  Sponsor:   Evolve BioSystems, Inc.
  Recruiting
• Ideal Steroids for Asthma Treatment in the PICU

  NCT03900624

  Condition:   Asthma Childhood
  Intervention:   Drug: Dexamethasone
  Sponsor:   Johns Hopkins All Children's Hospital
  Enrolling by invitation
• Culturally Modified Family Based Therapy for Haitian Youth in South Florida

  NCT03876171

  Condition:   Problem Behavior
  Interventions:   Behavioral: Haitian youth and family intervention study: family functioning;   Behavioral: Haitian youth intervention study: youth psychoeducational;   Behavioral: Haitian family intervention study: family psychoeducational;   Behavioral: Diversion Programs
  Sponsors:   University of Miami;   National Institute on Drug Abuse (NIDA)
  Recruiting
• Targeting Burdensomeness Among Clinic Referred Youth

  NCT03781037

  Condition:   Perceived Burdensomeness Toward Others
  Intervention:   Behavioral: GIVE Module
  Sponsor:   Florida International University
  Recruiting
• Arterial Oxygen Saturation on Ventilatory Stability in Extremely Premature Infants

  NCT03695900

  Conditions:   Apnea of Prematurity;   Desaturation of Blood;   Central Apnea;   Periodic Breathing;   Obstructive Apnea of Newborn
  Interventions:   Other: Targeting SpO2 at 93-95%;   Other: Targeting SpO2 at 90-92%
  Sponsors:   University of Miami;   The Gerber Foundation
  Recruiting
• Evaluation of Trigeminal Nerve Blockade

  NCT03632044

  Conditions:   Mouth Abnormalities;   Cleft Palate;   Birth Defect
  Interventions:   Drug: Ropivacaine;   Other: Sham Comparator
  Sponsor:   University of Florida
  Enrolling by invitation
• Functional MRI Study in Healthy Children Engaged in Aggressive Behaviors

  NCT03615703

  Condition:   Impulsive Aggression
  Intervention:  
  Sponsor:   Supernus Pharmaceuticals, Inc.
  Completed
• Pharmacokinetic Study of DYANAVEL XR (Amphetamine) Extended-release Oral Suspension, in Children Aged 4 to 5 Years

  NCT03610464

  Condition:   Attention Deficit Hyperactivity Disorder
  Intervention:   Drug: Amphetamine Extended Release Suspension [Dyanavel]
  Sponsor:   Tris Pharma, Inc.
  Completed
• Inhaled Nitric Oxide for Pulmonary Hypertension and Bronchopulmonary Dysplasia

  NCT03576885

  Conditions:   Pulmonary Hypertension;   Bronchopulmonary Dysplasia
  Interventions:   Drug: inhaled nitric oxide;   Drug: Placebo
  Sponsors:   Florida Hospital;   Mallinckrodt;   Thrasher Research Fund
  Recruiting
• Improving Satisfaction, Engagement and Outcomes Among Traditionally Underserved Children Through Cultural Formulation

  NCT03499600

  Condition:   Disruptive Behavior
  Interventions:   Behavioral: Clinical Assessment and CFI;   Behavioral: Clinical Assessment
  Sponsors:   Florida International University;   University of Miami
  Completed
• Microfluidic Assessment of Clinical Outcomes in Preterm Newborns

  NCT03291496

  Condition:   Neonatal SEPSIS
  Interventions:   Other: Blood Collection Preterm;   Other: Blood Collection Term
  Sponsors:   University of Florida;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
  Recruiting
• PEARLS Intervention

  NCT03260062

  Condition:   Deafness, Bilateral
  Interventions:   Behavioral: Parent-Child Early Approaches to Raising Language Skills;   Other: Standard Care Speech therapy
  Sponsors:   University of Miami;   National Institute on Deafness and Other Communication Disorders (NIDCD)
  Recruiting
• Technology and Early Anxiety Treatment

  NCT03255122

  Condition:   Anxiety Disorders
  Interventions:   Behavioral: I-CALM;   Behavioral: Delayed I-CALM
  Sponsors:   Florida International University;   Andrew Kukes Foundation for Social Anxiety
  Recruiting
• Intranasal Oxytocin for Infants With Prader-Willi Syndrome

  NCT03245762

  Condition:   Prader-Willi Syndrome
  Interventions:   Drug: Oxytocin;   Drug: Placebo
  Sponsors:   University of Florida;   Prader-Willi Syndrome Association
  Completed
• Comparison of Primary Extubation Failure Between NIPPV and NI-NAVA

  NCT03242057

  Conditions:   Preterm Infant;   BPD - Bronchopulmonary Dysplasia;   Barotrauma
  Interventions:   Other: NAVA;   Other: NIPPV
  Sponsor:   University of Florida
  Completed
• A Crowdsourced Social Media Portal for Parents of Very Young Children With Type 1 Diabetes

  NCT03222180

  Condition:   Type 1 Diabetes Mellitus
  Intervention:   Behavioral: Website
  Sponsor:   Nemours Children's Clinic
  Active, not recruiting
• Methadone Demonstration Project

  NCT03134703

  Condition:   Neonatal Abstinence Syndrome
  Interventions:   Drug: Methadone;   Drug: Morphine
  Sponsors:   Johns Hopkins All Children's Hospital;   Florida Department of Health
  Terminated
• Efficacy of Pea Hull Fiber - Phase 2

  NCT03016065

  Condition:   Healthy
  Interventions:   Dietary Supplement: Pea Fiber;   Dietary Supplement: Control
  Sponsors:   University of Florida;   Saskatchewan Pulse Growers
  Active, not recruiting
• Efficacy of Auricular Acupuncture on Neonatal Abstinence Syndrome

  NCT02872077

  Condition:   Neonatal Abstinence Syndrome
  Intervention:   Other: Auricular acupuncture
  Sponsor:   University of South Florida
  Completed
• Antibiotic "Dysbiosis" in Preterm Infants

  NCT02784821

  Conditions:   Enterocolitis, Necrotizing;   Bacteremia;   Bronchopulmonary Dysplasia;   Intraventricular Hemorrhage;   Periventricular Leukomalacia;   Chronic Lung Disease;   Retinopathy of Prematurity;   Ileal Perforation
  Interventions:   Drug: Antibiotic;   Other: Gastric fluid;   Other: Breast milk;   Other: Stool samples;   Drug: Antibiotics - pre-emptive;   Other: Skin swabs
  Sponsors:   University of Florida;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   Society for Pediatric Dermatology
  Completed
• STAND Community Trial

  NCT02694939

  Condition:   Attention Deficit Hyperactivity Disorder
  Interventions:   Behavioral: STAND (Behavior Therapy + Motivational Interviewing);   Behavioral: Usual Care
  Sponsor:   Florida International University
  Active, not recruiting
• Severe Sepsis in Children - IMPRESS-C

  NCT02598674

  Conditions:   Acute Kidney Injury;   Chronic Kidney Disease;   Hypertension
  Interventions:   Drug: Iodohippurate;   Procedure: 24 hour ambulatory Blood Pressure;   Procedure: Peripheral Arterial Tonometry;   Procedure: Pulse Wave Velocity;   Drug: Gadolinium
  Sponsors:   University of Florida;   American Society of Nephrology
  Not yet recruiting
• JUEGA: A Fun Study for Hispanic/Latino Adolescent Girls

  NCT02578147

  Condition:   Adolescent Behavior
  Interventions:   Behavioral: Mighty Girls;   Behavioral: Game Girls
  Sponsors:   University of Miami;   National Institute of Nursing Research (NINR)
  Terminated
• Intervention for Teens With ADHD and Substance Use

  NCT02502799

  Condition:   Attention Deficit Hyperactivity Disorder
  Interventions:   Behavioral: Brief Early Intervention;   Behavioral: Parent Training with Adolescent Cognitive Behavioral Therapy;   Drug: Methylphenidate
  Sponsor:   Florida International University
  Recruiting
• Respiratory Muscle Function in Untreated X-Linked Myotubular Myopathy (XLMTM)

  NCT02453152

  Condition:   X-linked Myotubular Myopathy
  Interventions:   Other: History and physical;   Other: Tidal breathing;   Other: Maximal respiratory pressures;   Other: Peak cough flow;   Other: Pediatric Evaluation of Disability Inventory;   Other: PedsQL Multidimensional Fatigue Scale;   Other: Review of ventilation requirements
  Sponsors:   University of Florida;   Audentes Therapeutics
  Completed
• A Within Subjects Comparison of Two Antegrade Flushing Regimens in Children

  NCT02435069

  Conditions:   Fecal Incontinence;   Neurogenic Bowel
  Interventions:   Drug: Dose Response - NS and USP Glycerin - First Intervention;   Drug: Effectiveness - NS and USP Glycerin - Second Intervention
  Sponsors:   Nemours Children's Clinic;   University of Florida
  Completed
• Improving Medication Adherence in ADHD Adolescents

  NCT02271880

  Condition:   ADHD
  Interventions:   Other: Medication as usual;   Other: STAR
  Sponsor:   Florida International University
  Terminated
• Assessment of Cardiopulmonary Function in Duchenne Muscular Dystrophy

  NCT02195999

  Condition:   Muscular Dystrophy, Duchenne
  Interventions:   Other: Magnetic Resonance Imaging (MRI);   Other: Pulmonary Function Testing (PFT);   Other: Metabolic Exercise Testing using stationary bicycle;   Other: Echocardiogram
  Sponsors:   University of Florida;   CureDuchenne
  Completed
• Prospective Evaluation of Lingual Frenotomy in Newborns With Simultaneous Lip Tie for the Relief of Breastfeeding Pain.

  NCT02141243

  Conditions:   Ankyloglossia;   Breast Feeding;   Enlarged Labial Frenum
  Interventions:   Procedure: Lingual Frenotomy;   Procedure: Labial Frenotomy;   Procedure: Sham Procedure
  Sponsor:   University of South Florida
  Completed
• Acupuncture in Neonatal Abstinence Syndrome (NAS) Babies

  NCT02062151

  Condition:   Neonatal Abstinence Syndrome
  Intervention:   Other: Acupuncture
  Sponsor:   University of South Florida
  Completed
• Examining Tolerance to CNS Stimulants in ADHD

  NCT02039908

  Condition:   Attention-deficit/Hyperactivity Disorder
  Intervention:   Drug: Methylphenidate
  Sponsor:   Florida International University
  Active, not recruiting
• Early Detection of Progressive Kidney Disease in Preterm Infants

  NCT02000895

  Conditions:   Kidney Disease;   Cardiovascular Disease
  Intervention:  
  Sponsor:   University of Miami
  Recruiting
• Exposure-Focused Family-Based CBT for Youth With ASD and Comorbid Anxiety

  NCT01919970

  Conditions:   Autism;   Asperger's Syndrome;   Pervasive Developmental Disorder Not Otherwise Specified;   Generalized Anxiety Disorder;   Social Phobia;   Separation Anxiety Disorder;   Obsessive-compulsive Disorder;   Specific Phobia
  Interventions:   Other: Cognitive Behavioral Therapy;   Other: Treatment as usual
  Sponsor:   University of South Florida
  Completed
• Early iNO for Oxidative Stress, Vascular Tone and Inflammation in Babies With Hypoxic Respiratory Failure

  NCT01891500

  Conditions:   Persistent Fetal Circulation Syndrome;   Hypertension, Pulmonary, of Newborn, Persistent;   Persistent Pulmonary Hypertension of Newborn
  Interventions:   Drug: Inhaled nitric oxide;   Drug: Nitrogen Gas;   Drug: Crossover iNO
  Sponsors:   University of Florida;   Mallinckrodt
  Recruiting
• Observational Study in Preterm Infants With Intracranial Hemorrhage

  NCT01620203

  Conditions:   Intracranial Hemorrhage;   Intraventricular Hemorrhage;   Cerebral Hypoxia
  Intervention:  
  Sponsor:   Nelson Claure
  Recruiting
• Sleep and Emotional Memory in Peripubertal Anxiety

  NCT03643848

  Condition:   Anxiety
  Interventions:   Behavioral: Sleep with Sound Cues;   Behavioral: Sleep with Sham Cues
  Sponsor:   Florida International University
  Recruiting
• Exposure Therapy for Auditory Sensitivity in Autism

  NCT03206996

  Conditions:   Sensory Disorders;   Autism;   Autism Spectrum Disorder;   Autism With High Cognitive Abilities;   Autistic Behavior;   Hyperacusis
  Interventions:   Behavioral: Exposure therapy;   Behavioral: Psycho-education;   Behavioral: Caregiver education/home program development
  Sponsor:   University of Florida
  Completed
• Combination of Acetaminophen and Ibuprofen in the Management of Patent Ductus Arteriosus

  NCT03103022

  Conditions:   Patent Ductus Arteriosus;   Neonate
  Interventions:   Drug: Acetaminophen;   Drug: ibuprofen
  Sponsor:   University of Florida
  Completed
• Human Fibrinogen Concentrate in Pediatric Cardiac Surgery

  NCT02822599

  Conditions:   Hypofibrinogenemia;   Afibrinogenemia;   Bleeding Disorders
  Interventions:   Drug: RiaStAP;   Drug: Saline
  Sponsor:   Nicklaus Children's Hospital f/k/a Miami Children's Hospital
  Completed
• Effects of Platelet Rich Plasma Injections on Biomarkers After Anterior Cruciate Ligament Tears

  NCT04088227

  Conditions:   Anterior Cruciate Ligament Tear;   Anterior Cruciate Ligament Rupture
  Interventions:   Drug: Experimental Group;   Other: Control Group
  Sponsor:   Andrews Research & Education Foundation
  Recruiting
• Prosthetic Device in Children With Upper Congenital Limb Deficiency

  NCT04059107

  Condition:   Upper Limb Deformities, Congenital
  Intervention:   Device: 3D Printed Myoelectric Prosthetic Device
  Sponsors:   Oregon Health and Science University;   Limbitless Solutions;   University of Central Florida
  Enrolling by invitation
• Investigating Event-Related Potentials and Eye-Tracking Measures in Hockey Players

  NCT03975023

  Conditions:   Healthy;   Traumatic Brain Injury
  Intervention:   Device: NeuroCatch Platform (NCP)
  Sponsors:   Frederick Carrick, PhD, FACCN;   HealthTech Connex Inc.
  Recruiting
• Observational Trial of the Impact of Radiation Dose in Children With Brain and Skull Base Tumors.

  NCT03972514

  Conditions:   Brain Tumor;   Brain Cancer;   Skull Base Tumor
  Intervention:  
  Sponsor:   Baptist Health South Florida
  Recruiting
• Early Administration of Steroids in the Ambulance Setting

  NCT03962894

  Condition:   Asthma in Children
  Intervention:   Drug: Prednisolone
  Sponsor:   University of Florida
  Not yet recruiting
• Lactobacillus Johnsonii in Children and Adolescents With T1D

  NCT03961854

  Condition:   Type 1 Diabetes (T1D)
  Interventions:   Drug: L. johnsonii Probiotic;   Drug: Placebo Capsule
  Sponsors:   University of Florida;   Juvenile Diabetes Research Foundation
  Not yet recruiting
• Ex Vivo Drug Sensitivity Testing and Mutation Profiling

  NCT03860376

  Conditions:   Recurrent Childhood Acute Myeloid Leukemia;   Recurrent Childhood Acute Lymphoblastic Leukemia;   Recurrent Childhood Large Cell Lymphoma;   Refractory Childhood Acute Lymphoblastic Leukemia;   Refractory Childhood Hodgkin Lymphoma;   Refractory Childhood Malignant Germ Cell Neoplasm;   Recurrent Childhood Brain Tumor;   Recurrent Childhood Brainstem Glioma;   Recurrent Childhood Rhabdomyosarcoma;   Recurrent Childhood Soft Tissue Sarcoma;   Recurrent Childhood Ependymoma;   Recurrent Childhood Lymphoblastic Lymphoma;   Recurrent Childhood Gliosarcoma;   Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive
  Intervention:  
  Sponsors:   Florida International University;   Nicklaus Children's Hospital f/k/a Miami Children's Hospital
  Recruiting
• Vorinostat Dose-escalation After Allogeneic Hematopoietic Cell Transplantation

  NCT03843528

  Conditions:   Acute Myeloid Leukemia;   Myelodysplastic Syndromes;   Mixed Phenotype Acute Leukemia;   Juvenile Myelomonocytic Leukemia
  Interventions:   Drug: Vorinostat;   Drug: Azacitidine Injection
  Sponsor:   Johns Hopkins All Children's Hospital
  Recruiting
• Diabetes Autoimmunity Withdrawn in New Onset Patients (DAWN)

  NCT03794973

  Condition:   Diabetes Mellitus, Type 1
  Interventions:   Biological: TOL-3021;   Other: TOL-3021 Placebo
  Sponsor:   Tolerion, Inc.
  Not yet recruiting
• Computer Assisted Family Intervention to Treat Self-Harm Disparities in Latinas and Sexual/Gender Minority Youth

  NCT03709472

  Conditions:   Self Harm;   Depression;   Emotion Dysregulation;   Behavior Problem
  Interventions:   Behavioral: Computer Assisted CIFFTA;   Behavioral: Behavioral: Traditional face-to-face treatment-no technology
  Sponsors:   University of Miami;   National Institute on Minority Health and Health Disparities (NIMHD)
  Recruiting
• Training Language and Literacy for Children Who Use CIs

  NCT03582566

  Condition:   Hearing Loss, Sensorineural
  Interventions:   Behavioral: Phonological Awareness;   Behavioral: Working Memory;   Behavioral: Phonological Awareness + Working Memory;   Behavioral: Active Control
  Sponsors:   Florida State University;   Northwestern University
  Recruiting
• Comparing Speedlyte and IV Rehydration Treating Children With Gastroenteritis in a Pediatric Emergency Department (ED)

  NCT03562702

  Conditions:   Dehydration;   Acute Gastroenteritis
  Interventions:   Other: Standard IV Rehydration Therapy;   Other: Oral Rehydration Therapy (ORT)
  Sponsors:   Nicklaus Children's Hospital f/k/a Miami Children's Hospital;   Einsoff Biohealth, LLC
  Recruiting
• Conditioning Regimen for Allogeneic Hematopoietic Stem-Cell Transplantation

  NCT03513328

  Conditions:   Bone Marrow Failure Syndrome;   Thalassemia;   Sickle Cell Disease;   Diamond Blackfan Anemia;   Acquired Neutropenia in Newborn;   Acquired Anemia Hemolytic;   Acquired Thrombocytopenia;   Hemophagocytic Lymphohistiocytoses;   Wiskott-Aldrich Syndrome;   Chronic Granulomatous Disease;   Common Variable Immunodeficiency;   X-linked Lymphoproliferative Disease;   Severe Combined Immunodeficiency;   Hurler Syndrome;   Mannosidosis;   Adrenoleukodystrophy
  Interventions:   Drug: Thiotepa--single daily dose;   Drug: Thiotepa--escalated dose
  Sponsors:   University of Florida;   Live Like Bella Pediatric Cancer Research
  Recruiting
• Type 2 Diabetes and the Brain in Adolescents

  NCT03461510

  Conditions:   Type 2 Diabetes Mellitus;   Obesity;   Pediatric Obesity;   Insulin Resistance;   Dysglycemia;   Hyperglycemia
  Interventions:   Procedure: Hyperglycemic clamp;   Procedure: Hyperinsulinemic Euglycemic clamp
  Sponsor:   Nemours Children's Clinic
  Completed
• Diagnostic Odyssey: Whole Genome Sequencing (WGS)

  NCT03458962

  Conditions:   Genetic Disease;   Genetic Syndrome
  Intervention:   Genetic: Genetic Enrollees
  Sponsors:   Nicklaus Children's Hospital f/k/a Miami Children's Hospital;   Rady Pediatric Genomics & Systems Medicine Institute
  Enrolling by invitation
• Study of Stool Patterns to Collect a Panel of Stool Images for the Development of a Software

  NCT03402555

  Condition:   Healthy
  Intervention:   Other: Stool pattern
  Sponsors:   Danone Asia Pacific Holdings Pte, Ltd.;   ObvioHealth
  Active, not recruiting
• Microdystrophin Gene Transfer Study in Adolescents and Children With DMD

  NCT03368742

  Condition:   Duchenne Muscular Dystrophy
  Intervention:   Genetic: SGT-001
  Sponsor:   Solid Biosciences, LLC
  Recruiting
• Adoptive Cellular Therapy in Pediatric Patients With High-grade Gliomas

  NCT03334305

  Condition:   Malignant Glioma
  Interventions:   Biological: TTRNA-DC vaccines with GM-CSF;   Drug: Dose-intensified TMZ;   Biological: Autologous Hematopoietic Stem cells (HSCs);   Biological: TTRNA-xALT;   Drug: Td vaccine
  Sponsors:   University of Florida;   National Pediatric Cancer Foundation;   National Cancer Institute (NCI);   Moffitt Clinical Research Network (MCRN);   National Institutes of Health (NIH)
  Recruiting
• Wellness Achieved Through Changing Habits (The WATCH Study)

  NCT03284788

  Conditions:   Weight Loss;   Obesity;   Overweight
  Intervention:   Behavioral: ABT Weight Loss Intervention
  Sponsors:   University of Florida;   StayWell;   National Heart, Lung, and Blood Institute (NHLBI);   WellCare Health Plans, Inc.
  Recruiting
• Development of a Behavioral Outcome Measure for Rett Syndrome (RettBe)

  NCT03196323

  Condition:   Rett Syndrome
  Intervention:  
  Sponsors:   University of South Florida;   National Institutes of Health (NIH);   National Center for Advancing Translational Science (NCATS);   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Institute of Neurological Disorders and Stroke (NINDS)
  Recruiting
• Skeletal Muscle and Adipose Tissue Study

  NCT03190668

  Condition:   Idiopathic Scoliosis
  Interventions:   Drug: Bolus dose of Cefazolin;   Drug: Continuous Cefazolin drip;   Device: Paraspinal muscle microdialysis catheters;   Device: Subcutaneous microdialysis catheters
  Sponsor:   University of Florida
  Recruiting
• Use of RM Technology in Pediatric BAI Recipients

  NCT03149484

  Condition:   Hearing Loss, Unilateral
  Interventions:   Device: Personal remote microphone (RM) system;   Other: Subjective Questionnaire
  Sponsor:   University of Miami
  Completed
• HUMC 1612: Optune NovoTTF-200A System

  NCT03128047

  Conditions:   High Grade Glioma;   Ependymoma
  Intervention:   Device: Optune NovoTTF-200A System
  Sponsors:   Hackensack Meridian Health;   NovoCure Ltd.
  Recruiting
• Study of Lenalidomide With Vorinostat in Pediatric Patients With High Grade or Progressive CNS Tumors

  NCT03050450

  Condition:   Central Nervous System Tumors
  Interventions:   Drug: 25 mg/m2 Lenalidomide (Revlimid®) and 180 mg/m2 Vorinostat (Zolinza®);   Drug: 50 mg/m2 Lenalidomide (Revlimid®) and 180 mg/m2 Vorinostat (Zolinza®);   Drug: 100 mg/m2 Lenalidomide (Revlimid®) and 180 mg/m2 Vorinostat (Zolinza®);   Drug: 150 mg/m2 Lenalidomide (Revlimid®) and 180 mg/m2 Vorinostat (Zolinza®);   Drug: 150 mg/m2 Lenalidomide (Revlimid®) and 230 mg/m2 Vorinostat (Zolinza®)
  Sponsor:   Johns Hopkins All Children's Hospital
  Suspended
• A Feasibility Safety Study of Benign Centrally-Located Intracranial Tumors in Pediatric and Young Adult Subjects

  NCT03028246

  Condition:   Benign Centrally-Located Intracranial Tumors
  Intervention:   Device: ExAblate 4000 System
  Sponsor:   InSightec
  Recruiting
• Lactate Acidosis in Postoperative Hearts

  NCT03025659

  Conditions:   Post-cardiac Surgery;   Hyperlactatemia
  Intervention:   Other: Pyruvate levels
  Sponsor:   University of Florida
  Completed
• Integrating Pharmacogenomic Testing Into a Child Psychiatry Clinic

  NCT02855580

  Conditions:   Obsessive Compulsive Disorder;   Major Depressive Disorder;   Anxiety
  Intervention:  
  Sponsor:   University of Florida
  Completed
• Steroids in Children Hospitalized With Asthma

  NCT02780479

  Conditions:   Asthma;   Status Asthmaticus;   Wheezes
  Interventions:   Drug: Dexamethasone;   Drug: Prednisone
  Sponsor:   University of Florida
  Terminated
• Strata Programmable CSF Shunt Valve Study

  NCT02737163

  Condition:   Hydrocephalus
  Intervention:  
  Sponsor:   Johns Hopkins All Children's Hospital
  Terminated
• Influence of Monopoly Game on Subtle Behaviors

  NCT02729389

  Conditions:   Psychosocial Influence on Cardiovascular Disease;   Cardiovascular Disease
  Interventions:   Behavioral: High Social Status Condition;   Behavioral: Low Social Status Condition
  Sponsors:   University of Florida;   University of Alabama at Birmingham;   Brown University
  Completed
• Advancing Child Competencies by Extending Supported Services (ACCESS) for Families Program

  NCT03260816

  Conditions:   Developmental Delay;   Disruptive Behavior
  Interventions:   Behavioral: Internet-delivered Parent-Child Interaction Therapy (I-PCIT);   Other: Referrals as Usual (RAU)
  Sponsors:   Florida International University;   University of Miami;   Nicklaus Children's Hospital f/k/a Miami Children's Hospital;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
  Active, not recruiting
• Evaluation of Adrenal Suppression Potential and Pharmacokinetics of Halobetasol Lotion 0.05%

  NCT03212963

  Condition:   Plaque Psoriasis
  Intervention:   Drug: Halobetasol Topical Lotion
  Sponsor:   Sun Pharmaceutical Industries Limited
  Completed
• Non-invasive Clinical Pectus Index as a Measurement of Severity in Pectus

  NCT02552186

  Condition:   Pectus Excavatum
  Intervention:   Other: Caliper measurement
  Sponsor:   Johns Hopkins All Children's Hospital
  Recruiting
• The OneFlorida Cancer Control Alliance: Implementing the 6As in Pediatric Primary Care

  NCT03044691

  Condition:   Smoking Cessation
  Intervention:   Behavioral: ResearchACTS software
  Sponsor:   University of Florida
  Terminated
• Trans-incisional vs Laparoscopic Guided Rectus Sheath Block for Pediatric Single Incision Laparoscopic Cholecystectomy

  NCT02494336

  Condition:   Pain, Postoperative
  Interventions:   Procedure: Trans-incisional rectus sheath block;   Procedure: Laparoscopic guided rectus sheath block;   Drug: Ropivacaine
  Sponsor:   Johns Hopkins All Children's Hospital
  Active, not recruiting
• Anesthetic Optimization in Scoliosis Surgery

  NCT02481570

  Conditions:   Adolescent Idiopathic Scoliosis;   Respiratory Depression;   Postoperative Pain
  Intervention:   Other: pharmacokinetic simulation
  Sponsor:   University of Florida
  Completed
• Long Term Cognitive Impact of Pediatric Acute Renal Injury

  NCT02372734

  Condition:   Acute Kidney Injury
  Intervention:   Other: Pediatric Quality of Life (Peds QL) Survey
  Sponsors:   University of Florida;   American Society of Nephrology
  Recruiting
• Diet and Exercise in Pompe Disease

  NCT02363153

  Conditions:   Pompe Disease;   Glycogen Storage Disease Type II;   Lysosomal Storage Diseases
  Intervention:   Other: Diet and Exercise
  Sponsors:   University of Florida;   Amicus Therapeutics
  Recruiting
• Ketogenic Therapy Effects on Electrical and Metabolic Abnormalities in Epilepsy

  NCT02216500

  Condition:   Seizures
  Intervention:   Dietary Supplement: Ketogenic Therapy
  Sponsor:   University of Florida
  Recruiting
• Targeting Attention Orienting to Social Threat to Reduce Social Anxiety in Youth

  NCT03932032

  Condition:   Social Anxiety Disorder of Childhood
  Interventions:   Behavioral: Attention Bias Modification Treatment;   Behavioral: Neutral Control Task
  Sponsors:   Florida International University;   Yale University
  Recruiting
• Autologous Stem Cell Transplantation for Patients With Recurrent Nasopharyngeal Carcinoma

  NCT02137096

  Condition:   Recurrent Nasopharynx Carcinoma
  Interventions:   Drug: Etoposide phosphate;   Drug: Carboplatin;   Drug: Ifosfamide;   Procedure: Autologous Stem Cell Transplantation
  Sponsor:   University of Florida
  Terminated
• Open-Label Safety and PK Study of ER Hydromorphone Tablets in Opioid-Tolerant Pediatric Chronic Pain Patients

  NCT02321319

  Condition:   Chronic Pain
  Intervention:   Drug: Hydromorphone HCl ER Tablets
  Sponsor:   Mallinckrodt
  Terminated
• Attention Training to Modify Error-related Negativity and Risk for Anxiety in Adolescence

  NCT03176004

  Condition:   Anxiety
  Intervention:   Other: Attention Bias Modification
  Sponsors:   Florida State University;   San Diego State University
  Recruiting
• Diffuse Intrinsic Pontine Glioma (DIPG) Reirradiation (ReRT)

  NCT01469247

  Condition:   Brain Cancer
  Intervention:   Radiation: Radiation Therapy
  Sponsors:   M.D. Anderson Cancer Center;   National Cancer Institute (NCI)
  Active, not recruiting
• Proteinuria in Pre and Post Transplant

  NCT01094327

  Condition:   Proteinuria
  Intervention:  
  Sponsor:   University of Miami
  Recruiting
• Outcomes Study of Late Effects After Proton RT for Pediatric Tumors of the Brain, Head, and Neck

  NCT01067196

  Condition:   Central Nervous System Tumors
  Intervention:  
  Sponsor:   University of Florida
  Active, not recruiting
• Study of Irinotecan and Bevacizumab With Temozolomide in Refractory/Relapsed Central Nervous System (CNS) Tumors

  NCT00876993

  Condition:   Central Nervous System Tumors
  Interventions:   Drug: Bevacizumab;   Drug: Irinotecan;   Drug: Temozolomide
  Sponsors:   Johns Hopkins All Children's Hospital;   V Foundation;   Brain Tumor Alliance
  Completed
• Brain Stem Gliomas Treated With Adoptive Cellular Therapy During Focal Radiotherapy Recovery Alone or With Dose-intensified Temozolomide (Phase I)

  NCT03396575

  Condition:   Diffuse Intrinsic Pontine Glioma (DIPG)
  Interventions:   Biological: TTRNA-DC vaccines with GM-CSF;   Biological: TTRNA-xALT;   Drug: Cyclophosphamide + Fludarabine Lymphodepletive Conditioning;   Drug: Dose-Intensified TMZ;   Drug: Td vaccine;   Biological: Autologous Hematopoietic Stem Cells (HSC)
  Sponsors:   University of Florida;   Accelerate Brain Cancer Cure;   Lyla Nsouli Foundation
  Recruiting
• Pevonedistat With VXLD Chemotherapy for Adolescent/Young Adults With Relapsed/Refractory Acute Lymphoblastic Leukemia

  NCT03349281

  Conditions:   Refractory Acute Lymphoblastic Leukemia;   Relapsed Acute Lymphoblastic Leukemia
  Interventions:   Drug: Pevonedistat;   Drug: Vincristine;   Drug: Dexamethasone;   Drug: PEG-asparaginase;   Drug: Doxorubicin;   Drug: Cytarabine;   Drug: Methotrexate;   Drug: Hydrocortisone
  Sponsors:   Julio Barredo;   Takeda
  Recruiting
• Normative Oculomotor and Vestibular Data in Pediatric Population

  NCT04107610

  Condition:   Healthy
  Intervention:   Device: I-PAS
  Sponsors:   Neuro Kinetics;   Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute);   University of Miami
  Not yet recruiting
• A Phase 2 Study for Dose Determination of SRP-5051, Then Dose Expansion in Patients With Duchenne Muscular Dystrophy Amenable to Exon 51-Skipping Treatment

  NCT04004065

  Condition:   Duchenne Muscular Dystrophy
  Intervention:   Drug: SRP-5051
  Sponsor:   Sarepta Therapeutics, Inc.
  Recruiting
• Nab-paclitaxel in Combination With Gemcitabine for Pediatric Relapsed and Refractory Solid Tumors

  NCT03507491

  Condition:   Cancer
  Interventions:   Drug: Gemcitabine;   Drug: Nab-paclitaxel
  Sponsors:   Emory University;   Celgene Corporation
  Recruiting
• LYNX: A Novel Mobile App to Support Linkage to HIV/STI Testing PrEP for Young Men Who Have Sex With Men

  NCT03177512

  Conditions:   HIV;   Sexually Transmitted Diseases;   Risk Reduction;   Pre-Exposure Prophylaxis
  Intervention:   Behavioral: LYNX Mobile App
  Sponsors:   Public Health Foundation Enterprises, Inc.;   Cook County Health & Hospitals System;   Duke University;   Emory University;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   San Francisco Department of Public Health;   University of California, San Francisco;   University of North Carolina, Chapel Hill;   University of South Florida
  Active, not recruiting
• Phase I Study of Mebendazole Therapy for Recurrent/Progressive Pediatric Brain Tumors

  NCT02644291

  Conditions:   Medulloblastoma;   Astrocytoma, Grade III;   Glioblastoma;   Anaplastic Astrocytoma;   Brain Stem Neoplasms, Malignant;   Oligodendroblastoma;   Anaplastic Oligodendroglioma;   Malignant Glioma
  Intervention:   Drug: Mebendazole
  Sponsor:   Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
  Recruiting
• A Phase II Trial of Limited Surgery and Proton Therapy for Craniopharyngioma or Observation After Radical Resection

  NCT01419067

  Condition:   Craniopharyngioma
  Interventions:   Procedure: Radical Surgery or Limited Surgery;   Device: Proton Therapy;   Drug: ^1^8F-fluorodeoxyglucose;   Drug: ^1^1C-methionine
  Sponsor:   St. Jude Children's Research Hospital
  Active, not recruiting
• Community Study of Outcome Monitoring for Emotional Disorders in Teens

  NCT02567266

  Conditions:   Depression;   Anxiety
  Interventions:   Behavioral: Unified Protocol for Adolescents (UP-A);   Behavioral: Youth Outcomes Questionnaire;   Behavioral: Treatment as Usual
  Sponsors:   University of Miami;   University of Connecticut;   National Institute of Mental Health (NIMH)
  Recruiting
• Stepped Care for Children After Trauma: Optimizing Treatment

  NCT02537678

  Condition:   Posttraumatic Stress Disorder
  Interventions:   Behavioral: Stepped Care TF-CBT;   Behavioral: Standard TF-CBT
  Sponsor:   University of South Florida
  Active, not recruiting
• Computerized Cognitive Behavioral Therapy for Childhood Anxiety in Community Health Centers

  NCT01416805

  Conditions:   Generalized Anxiety Disorder;   Social Phobia;   Separation Anxiety Disorder
  Interventions:   Behavioral: Computerized Cognitive Behavioral Therapy;   Behavioral: Treatment as usual
  Sponsors:   University of South Florida;   Access Behavioral Health;   Henderson Behavioral Health;   Directions for Mental Health
  Completed
• Exploratory fMRI Study on the Treatment for Impulsive Aggression in Children With ADHD

  NCT03638466

  Condition:   Attention Deficit Hyperactivity Disorder (ADHD)
  Interventions:   Drug: SPN-810;   Drug: Placebo
  Sponsor:   Supernus Pharmaceuticals, Inc.
  Recruiting
• Evaluation of Quality of Vision and Spectacle Independence With the AcrySof® Panoptix® Intraocular Lens

  NCT04124952

  Condition:   Cataract
  Intervention:   Device: Panoptix
  Sponsors:   SightTrust Eye Institute;   Science in Vision
  Enrolling by invitation
• Iron Absorption and Exercise

  NCT04079322

  Conditions:   Iron-deficiency;   Iron Deficiency Anemia
  Intervention:   Other: Meal
  Sponsor:   Florida State University
  Recruiting
• Tissue Oxygen Deprivation as Detected With Raman in Association With Umbilical Artery Catheters

  NCT04038203

  Condition:   Tissue Oxygenation
  Intervention:   Device: Resonance Raman Spectroscopy (RPS)
  Sponsor:   University of Florida
  Not yet recruiting
• Healthy Juntos Pilot Study

  NCT03986190

  Conditions:   Obesity;   Activity, Motor;   Diet, Healthy;   Sedentary Behavior
  Intervention:   Behavioral: Healthy Juntos
  Sponsors:   University of Miami;   National Heart, Lung, and Blood Institute (NHLBI)
  Not yet recruiting
• Open-label Extension Study of Brazikumab in Crohn's Disease

  NCT03961815

  Condition:   Crohn's Disease
  Intervention:   Drug: Brazikumab
  Sponsor:   Allergan
  Enrolling by invitation
• Home Video-based Telemedicine to Reduce Hypoglycemia Fear in Parents of Young Children

  NCT03914547

  Condition:   Type 1 Diabetes Mellitus
  Interventions:   Behavioral: REDCHiP;   Behavioral: ATTN
  Sponsors:   University of Kansas Medical Center;   Children's Mercy Hospital Kansas City;   University of Florida;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
  Not yet recruiting
• Focused Cardiac Ultrasound

  NCT03887286

  Conditions:   Ventricular Dysfunction;   Pericardial Effusion;   Valvular Disease;   Septal Defect
  Interventions:   Device: Philips EPIQ 7 ultrasound machine;   Device: Philips Lumify Broadband sector array transducer
  Sponsor:   University of Miami
  Completed
• The Loop Observational Study

  NCT03838900

  Condition:   Diabetes Mellitus, Type 1
  Intervention:   Device: Loop
  Sponsors:   Jaeb Center for Health Research;   Stanford University;   Tidepool Project;   RileyLink
  Active, not recruiting
• CircaHealth Development and Evaluation

  NCT03835572

  Conditions:   Health Behavior;   Health Knowledge, Attitudes, Practice;   Circadian Rhythm
  Interventions:   Other: CircaHealth: a course on circadian rhythms and health;   Other: Sleep hygiene materials
  Sponsors:   University of Miami;   Quantum Foundation
  Completed
• A Study of S6G5T 3 in the Treatment of Acne Vulgaris

  NCT03761810

  Condition:   Acne Vulgaris
  Interventions:   Drug: S6G5T-3;   Drug: S6G5T-8
  Sponsor:   Sol-Gel Technologies, Ltd.
  Recruiting
• The Effect Of An Anesthetic Procedure On Post Operative Pain Management In Carpal Tunnel Release

  NCT03729375

  Conditions:   Pain, Postoperative;   Carpal Tunnel Syndrome
  Interventions:   Drug: 10cc injection of bupivacaine;   Drug: 20cc injection of bupivacaine
  Sponsor:   University of South Florida
  Recruiting
• Omegaven as Alternative Parenteral Fat Nutrition

  NCT03662282

  Conditions:   Cholestasis;   Cholestasis of Parenteral Nutrition
  Intervention:   Drug: Omegaven
  Sponsor:   University of South Florida
  Completed
• Mission Reconnect- Delivering a Mobile and Web Based Self Directed Complementary And Integrative Health Program to Veterans and Their Partners to Manage Pain and PTSD

  NCT03593772

  Conditions:   PTSD;   Chronic Musculoskeletal Pain
  Intervention:   Behavioral: Mission Reconnect
  Sponsor:   VA Office of Research and Development
  Recruiting
• Adhear Bone Conduction System

  NCT03533686

  Conditions:   Hearing Loss, Conductive;   Hearing Loss, Unilateral
  Interventions:   Device: Adhear Bone Conduction System;   Device: Standard of Care
  Sponsors:   University of Miami;   Med-El Corporation
  Recruiting
• Oxygenation Instability and Maturation of Control of Breathing in Premature Infants

  NCT03445689

  Condition:   Infant,Premature
  Interventions:   Other: Assessment of oxygenation instability;   Other: Determination of mechanisms of hypoxemia episodes;   Other: Assessment of respiratory instability;   Other: apneic threshold of CO2;   Other: Assessment of peripheral chemoreceptor function;   Other: Assessment of central chemo-receptor function
  Sponsors:   University of Miami;   National Heart, Lung, and Blood Institute (NHLBI)
  Recruiting
• Effective Fraction of Inspired Oxygen With Nasal Cannula in Premature Infants

  NCT03431818

  Condition:   Oxygen Therapy
  Intervention:   Other: Nasal cannula flow rate
  Sponsor:   University of Miami
  Recruiting
• Pilot Study of OMEGA-3 and Vitamin D in High-Dose in Type I Diabetic Patients

  NCT03406897

  Conditions:   Diabetes Mellitus, Type 1;   Hypoglycemia;   Diabetes Mellitus;   Diabetes, Autoimmune
  Interventions:   Drug: Cholecalciferol;   Drug: Omega 3 fatty acid
  Sponsors:   Rodolfo Alejandro;   Diabetes Research Institute Foundation
  Recruiting
• Autologous Cardiac Stem Cell Injection in Patients With Hypoplastic Left Heart Syndrome: An Open Label Pilot Study.

  NCT03406884

  Condition:   Hypoplastic Left Heart Syndrome
  Interventions:   Drug: c-kit+ cells;   Drug: Placebo
  Sponsors:   Joshua M Hare;   University of Maryland, College Park
  Not yet recruiting
• BE Study of Fluticasone Propionate/Salmeterol Inhalation Powder in Asthma Patients

  NCT03394989

  Condition:   Bronchial Asthma
  Interventions:   Drug: Fluticasone propionate/salmeterol 100/50 µg;   Other: Placebo;   Drug: Advair Diskus 100/50 Dry Powder Inhaler, 60 ACTUAT
  Sponsor:   Cipla Ltd.
  Recruiting
• A Study to Assess the Safety and Local Tolerability of DFD-03 (Tazarotene) Lotion, 0.1% Compared to Tazorac® (Tazarotene) Cream, 0.1% in the Topical Treatment of Acne Vulgaris

  NCT03341910

  Condition:   Acne Vulgaris
  Interventions:   Drug: Tazarotene Lotion, 0.1%;   Drug: Tazarotene Cream, 0.1%;   Drug: Vehicle Lotion 0%;   Drug: Vehicle Cream 0%
  Sponsor:   Dr. Reddy's Laboratories Limited
  Completed
• Clinical Endpoint Study of Ivermectin 0.5% Lotion

  NCT03301649

  Condition:   Head Lice
  Interventions:   Drug: Ivermectin Lotion 0.5%;   Drug: Placebo/Vehicle Lotion
  Sponsor:   Actavis Inc.
  Completed
• Friends/Family in the Abortion Procedure Room (FAIR)

  NCT03227614

  Conditions:   Anxiety;   Pain;   Abortion
  Intervention:   Behavioral: Support Person Intervention
  Sponsor:   Planned Parenthood of Southwest and Central Florida
  Completed
• Clinical Applications of Advanced Ophthalmic Imaging

  NCT03135327

  Conditions:   Multiple Sclerosis;   Dry Eye Syndromes;   Diabetic Retinopathy;   Presbyopia;   Myopia;   Dementia
  Intervention:   Other: No intervention
  Sponsor:   University of Miami
  Recruiting
• Efficacy and Safety of IDP-124 Lotion

  NCT03002571

  Condition:   Atopic Dermatitis
  Interventions:   Drug: IDP-124 Lotion;   Drug: IDP-124 Vehicle Lotion
  Sponsor:   Bausch Health Americas, Inc.
  Recruiting
• Topical BPM31510 3.0% Cream in Patients With Epidermolysis Bullosa

  NCT02793960

  Condition:   Epidermolysis Bullosa
  Intervention:   Drug: topical BPM31510 3.0% Cream
  Sponsors:   Shasa Hu;   Berg, LLC
  Active, not recruiting
• Testing the Effectiveness of Behavioral Text Messages to Promote Attendance at HMRE Sessions

  NCT02787460

  Conditions:   Family Relations;   Marriage
  Intervention:   Behavioral: Behavioral Text Messages
  Sponsors:   Mathematica Policy Research, Inc.;   Department of Health and Human Services
  Recruiting
• Axitinib and Pembrolizumab in Subjects With Advanced Alveolar Soft Part Sarcoma and Other Soft Tissue Sarcomas

  NCT02636725

  Conditions:   Alveolar Soft Part Sarcoma;   Soft Tissue Sarcomas
  Interventions:   Drug: Axitinib;   Drug: Pembrolizumab;   Procedure: Blood Draw;   Procedure: Tumor Specimen Collection
  Sponsors:   Matteo Trucco, MD;   Merck Sharp & Dohme Corp.;   Pfizer
  Active, not recruiting
• Biomarkers in Friedreich's Ataxia

  NCT02497534

  Condition:   Friedreich's Ataxia
  Intervention:  
  Sponsors:   University of Florida;   Children's Miracle Network;   National Institutes of Health (NIH);   Friedreich's Ataxia Research Alliance
  Recruiting
• Clinical Usability of Nasal Glucagon in Treatment of Hypoglycemia in Children and Adolescents

  NCT02402933

  Conditions:   Hypoglycemia;   Diabetes Mellitus
  Intervention:   Drug: Nasal Glucagon
  Sponsor:   Eli Lilly and Company
  Completed
• Response to Diaphragmatic Pacing in Subjects With Pompe Disease

  NCT02354651

  Condition:   Pompe Disease
  Interventions:   Other: Pulmonary function testing;   Other: Resting breathing pattern;   Other: Respiratory muscle endurance test;   Other: Phrenic nerve stimulation;   Other: Maximal inspiratory pressure;   Other: Forced expiratory testing;   Other: EMG
  Sponsors:   University of Florida;   Acid Maltase Deficiency Association;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
  Recruiting
• Electroencephalogram (EEG) Triggered Functional Magnetic Resonance Imaging (fMRI) in Epilepsy Patients

  NCT02193932

  Condition:   Epilepsy
  Intervention:   Other: EEG Triggered fMRI using Micro Maglink
  Sponsor:   Baptist Health South Florida
  Completed
• Reducing Hospitalizations of Nursing Home Residents

  NCT02177058

  Condition:   Unnecessary Hospitalizations of Nursing Home Residents
  Interventions:   Other: INTERACT Quality improvement program;   Other: Quarterly surveys/data reporting
  Sponsors:   Florida Atlantic University;   National Institute of Nursing Research (NINR);   University of Minnesota - Clinical and Translational Science Institute
  Active, not recruiting
• Safety Study of an Adeno-associated Virus Vector for Gene Therapy of Leber's Hereditary Optic Neuropathy

  NCT02161380

  Condition:   Leber's Hereditary Optic Neuropathy
  Interventions:   Drug: injection of scAAV2-P1ND4v2 1.18x10e9 vg (Low),;   Drug: injection of scAAV2-P1ND4v2 5.81 X10e9 vg (Med);   Drug: injection of scAAV2-P1ND4v2 2.4 X10e10vg (High);   Drug: injection of scAAV2-P1ND4v2 1.0 X10e11vg (Higher)
  Sponsors:   John Guy;   National Eye Institute (NEI)
  Recruiting
• Flow-synchronized Nasal IMV in Preterm Infants

  NCT02085499

  Condition:   Premature Infants Requiring Non-invasive Respiratory Support
  Interventions:   Device: non-synchronized NIMV;   Device: Synchronized NIMV
  Sponsor:   University of Miami
  Recruiting
• Deep Brain Stimulation Effects on Gait and Balance in Patients With Parkinson's Disease

  NCT02022735

  Condition:   Parkinson's Disease
  Intervention:   Device: Deep Brain Stimulation
  Sponsor:   University of Miami
  Active, not recruiting
• The Preeclampsia Registry

  NCT02020174

  Conditions:   Preeclampsia;   Eclampsia;   HELLP Syndrome;   Toxemia;   Hypertensive Disorder of Pregnancy
  Intervention:  
  Sponsor:   Preeclampsia Foundation
  Recruiting
• Liver Fibrosis in Sickle Cell Disease

  NCT02007746

  Condition:   Sickle Cell Disease
  Interventions:   Other: Liver transient elastography (Fibroscan);   Other: Ferriscan;   Procedure: Liver biopsy in iron overloaded subjects.
  Sponsor:   University of Miami
  Recruiting
• Dendritic Cell (DC) Vaccine for Malignant Glioma and Glioblastoma

  NCT01808820

  Conditions:   Malignant Glioma;   Glioblastoma Multiforme;   Anaplastic Astrocytoma;   High Grade Glioma
  Interventions:   Biological: Dendritic Cell Vaccine;   Biological: Tumor Lysate;   Other: Imiquimod;   Procedure: Leukapheresis
  Sponsor:   Macarena De La Fuente
  Active, not recruiting
• Dendritic Cell Vaccine With or Without Gemcitabine Pre-Treatment for Adults and Children With Sarcoma

  NCT01803152

  Conditions:   Sarcoma;   Soft Tissue Sarcoma;   Bone Sarcoma
  Interventions:   Biological: Dendritic Cells Vaccine;   Biological: Lysate of Tumor;   Drug: Gemcitabine;   Drug: Imiquimod;   Procedure: Leukapheresis
  Sponsor:   Macarena De La Fuente
  Active, not recruiting
• Vaccine Combining Multiple Class I Peptides and Montanide ISA 51VG With Escalating Doses of Anti-PD-1 Antibody Nivolumab or Ipilimumab With Nivolumab For Patients With Resected Stages IIIC/ IV Melanoma

  NCT01176474

  Condition:   Melanoma (Skin)
  Interventions:   Biological: NY-ESO-1 157-165 (165V);   Drug: Nivolumab;   Biological: gp100:280-288 (288V);   Drug: Montanide ISA 51 vegetable grade (VG);   Drug: Ipilimumab;   Procedure: Apheresis Procedure
  Sponsors:   H. Lee Moffitt Cancer Center and Research Institute;   National Cancer Institute (NCI);   Medarex;   Bristol-Myers Squibb
  Active, not recruiting
• Multiple Class I Peptides & Montanide ISA 51 VG w Escalating Doses of Anti-PD-1 ab BMS936558

  NCT01176461

  Condition:   Melanoma (Skin)
  Interventions:   Biological: MART-1;   Biological: NY-ESO-1;   Biological: gp100:209-217(210M);   Biological: gp100:280-288(288V);   Drug: Montanide ISA 51 VG;   Biological: BMS-936558
  Sponsors:   H. Lee Moffitt Cancer Center and Research Institute;   National Cancer Institute (NCI);   Bristol-Myers Squibb;   Medarex
  Active, not recruiting
• The Insulin-Only Bionic Pancreas Bridging Study- Pediatric Transitional Study

  NCT04112069

  Condition:   Type1 Diabetes Mellitus
  Interventions:   Device: iLet Bionic Pancreas insulin-only configuration with Humalog or Novolog;   Other: Usual Care
  Sponsor:   Massachusetts General Hospital
  Completed
• Pediatric Infectious Disease Precision Medicine Using Sequencing Evaluation of CSF

  NCT03796546

  Conditions:   Infection;   Meningitis
  Intervention:  
  Sponsors:   IDbyDNA, Inc.;   Rady Children's Hospital, San Diego
  Enrolling by invitation
• Alpha-1 Foundation DNA and Tissue Bank

  NCT00884455

  Condition:   Alpha 1 Antitrypsin Deficiency
  Intervention:  
  Sponsors:   University of Florida;   Alpha-1 Foundation
  Enrolling by invitation
• Kuvan Therapy in Phenylketonuria (PKU): The Effect of Blood Phenylalanine Concentration on Kuvan Response

  NCT00841100

  Condition:   Phenylketonuria
  Interventions:   Drug: Kuvan;   Other: Diet
  Sponsor:   University of Miami
  Completed
• Florida Center for Brain Tumor Research

  NCT00811148

  Condition:   Brain Tumors
  Intervention:   Procedure: Tissue Bank
  Sponsor:   University of Florida
  Recruiting
• Biomechanics/Motion Analysis Laboratory Data Bank

  NCT00160771

  Condition:   Kinematics
  Intervention:   Behavioral: Joint Motion Analysis
  Sponsor:   University of Florida
  Recruiting
• Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Multiple Myeloma

  NCT00005792

  Conditions:   Multiple Myeloma;   Plasma Cell Neoplasm
  Interventions:   Drug: etoposide phosphate;   Drug: melphalan;   Drug: topotecan;   Procedure: Autologous Stem Cell Rescue
  Sponsors:   H. Lee Moffitt Cancer Center and Research Institute;   SmithKline Beecham;   Bristol-Myers Squibb
  Completed
• The Hemophilia Ultrasound Project

  NCT02807753

  Conditions:   Hemophilia A;   Hemophilia B
  Interventions:   Other: Ankle and Knee Ultrasound Joint Assessment;   Other: Ankle and Knee Magnetic Resonance Imaging
  Sponsors:   University of Miami;   Shire
  Recruiting
• A 4-week Study to Test Different Doses of BI 1265162 in Adolescents and Adults With Cystic Fibrosis Using the Respimat® Inhaler

  NCT04059094

  Condition:   Cystic Fibrosis
  Interventions:   Drug: BI 1265162;   Drug: Placebo
  Sponsor:   Boehringer Ingelheim
  Recruiting
• Expanded Access Protocol of Givosiran for Patients With Acute Hepatic Porphyria

  NCT04056481

  Condition:   Acute Hepatic Porphyria
  Intervention:   Drug: Givosiran
  Sponsor:   Alnylam Pharmaceuticals
  Available
• Adaptive Response to Intervention (RTI) for Students With ADHD

  NCT03511976

  Condition:   Attention Deficit Disorder With Hyperactivity
  Interventions:   Behavioral: Tier 1 Classroom Management;   Behavioral: Daily Report Card (DRC);   Behavioral: Enhanced DRC (DRC-E);   Drug: Stimulant
  Sponsors:   Florida International University;   University at Buffalo
  Recruiting
• Non-Invasive Detection of Tissue Oxygen Deprivation in Premature Infants With Patent Ductus Arteriosus.

  NCT03277768

  Conditions:   Premature Infant;   Patent Ductus Arteriosus;   Hemodynamic Instability
  Intervention:   Device: Resonance Raman Spectroscopy (RRS)
  Sponsors:   University of Florida;   Boston Children’s Hospital
  Completed
• A Study to Assess the Effectiveness of the Nautilus BrainPulse™ as an Aid in the Diagnosis of Concussion

  NCT02660164

  Condition:   Concussion
  Intervention:   Device: Nautilus BrainPulse Recording
  Sponsor:   Jan Medical, Inc.
  Recruiting
• Efficacy & Safety of STG320 Sublingual Tablets of HDM Allergen Extracts in Adults and Adolescents With HDM-associated AR

  NCT02443805

  Conditions:   Rhinitis, Allergic, Perennial;   House Dust Mite Allergy
  Interventions:   Biological: 300 IR;   Biological: Placebo
  Sponsor:   Stallergenes Greer
  Completed
• Incorporating teleCBIT Into a Hospital-Based Tic Program

  NCT04007913

  Conditions:   Tic Disorders;   Tourette Syndrome
  Intervention:   Behavioral: teleCBIT
  Sponsors:   San Jose State University;   American Academy of Neurology;   Tourette Association of America
  Completed
• Vaccine Immunotherapy for Recurrent Medulloblastoma and Primitive Neuroectodermal Tumor

  NCT01326104

  Conditions:   Medulloblastoma;   Neuroectodermal Tumor
  Interventions:   Biological: TTRNA-xALT;   Biological: TTRNA-DCs
  Sponsors:   University of Florida;   United States Department of Defense
  Active, not recruiting
• Reversing Type 1 Diabetes After it is Established

  NCT01106157

  Condition:   Diabetes Mellitus, Type 1
  Interventions:   Drug: Anti-Thymocyte Globin (ATG);   Drug: Placebo;   Drug: Pegylated GCSF
  Sponsors:   University of Florida;   The Leona M. and Harry B. Helmsley Charitable Trust;   Genzyme, a Sanofi Company
  Completed
• Risk-Adapted Focal Proton Beam Radiation and/or Surgery in Patients With Low, Intermediate and High Risk Rhabdomyosarcoma Receiving Standard or Intensified Chemotherapy

  NCT01871766

  Condition:   Rhabdomyosarcoma
  Interventions:   Drug: Vincristine;   Drug: Dactinomycin;   Drug: Cyclophosphamide;   Procedure: Surgical Resection;   Procedure: Radiation;   Drug: Bevacizumab;   Drug: Sorafenib;   Drug: Myeloid Growth Factor;   Procedure: Lymph Node Sampling;   Drug: Irinotecan;   Drug: Ifosfamide;   Drug: Etoposide;   Drug: Etoposide Phosphate;   Drug: Doxorubicin;   Drug: Dexrazoxane;   Drug: ^1^1C-methionine
  Sponsor:   St. Jude Children's Research Hospital
  Recruiting
• A Safety and Pharmacokinetics Study of IDP-122 Lotion in Pediatric Participants With Plaque Psoriasis

  NCT03987763

  Condition:   Psoriasis
  Intervention:   Drug: IDP-122 Lotion
  Sponsor:   Bausch Health Americas, Inc.
  Recruiting
• A Study to Assess the Pharmacokinetics (PK), Pharmacodynamics (PD) and Safety of 2-Week Treatment With Inhaled AZD7594 in Adolescents (12 to 17 Years) With Asthma

  NCT03976869

  Condition:   Asthma
  Intervention:   Drug: AZD7594
  Sponsors:   AstraZeneca;   Parexel
  Recruiting
• A Food Additive Removal Diet for Pediatric Eosinophilic Esophagitis

  NCT03657771

  Condition:   Eosinophilic Esophagitis
  Interventions:   Other: DED;   Other: FREE
  Sponsor:   Nemours Children's Clinic
  Recruiting
• Glycemic Control and the Brain in Children With Type 1 Diabetes

  NCT03428932

  Condition:   Type 1 Diabetes Mellitus
  Intervention:   Device: Closed Loop (Medtronic 670G)
  Sponsors:   Nemours Children's Clinic;   National Institutes of Health (NIH);   Washington University School of Medicine;   Stanford University;   University of Iowa;   Yale University;   Jaeb Center for Health Research
  Completed
• KP415 Classroom Study in Children (6-12 Years of Age) With ADHD

  NCT03292952

  Condition:   ADHD
  Interventions:   Drug: KP415 oral capsule;   Drug: Placebo oral capsule
  Sponsor:   KemPharm, Inc.
  Completed
• Implementing a Healthcare Provider Education Intervention in Rural Communities to Reduce Asthma Morbidity

  NCT04060823

  Condition:   Asthma
  Intervention:   Other: Easy Breathing program
  Sponsor:   University of Florida
  Recruiting
• Teacher Child Interaction Training (TCIT): Randomized Control Trial

  NCT04000230

  Condition:   Behavior, Child
  Interventions:   Behavioral: TCIT;   Behavioral: Booster
  Sponsors:   University of Miami;   The Children's Trust
  Recruiting
• Spanish Intervention for Caregivers of Veterans With Stroke

  NCT03142841

  Condition:   Depression
  Intervention:   Other: RESCUE Problem Solving Intervention
  Sponsor:   VA Office of Research and Development
  Recruiting
• Registry of Avive® Soft Tissue Membrane Utilization in Selected Applications of Acute Trauma of the Upper Extremity

  NCT03943134

  Condition:   Acute Upper Extremity Trauma
  Interventions:   Other: Minimally Processed Human Umbilical Cord Membrane;   Other: Standard Surgical Procedures
  Sponsor:   Axogen Corporation
  Recruiting
• Understanding Hemophilia A and B Drug Dosage Administration Patterns

  NCT03248141

  Conditions:   Hemophilia A;   Hemophilia B
  Interventions:   Drug: Hemophilia B standard half-life;   Drug: Hemophilia B extended half-life;   Drug: Hemophilia A standard half-life;   Drug: Hemophilia A extended half-life
  Sponsor:   Pfizer
  Terminated
• A Study to Investigate the Long-Term Safety of ZX008 (Fenfluramine Hydrochloride) Oral Solution in Children and Adults With Epileptic Encephalopathy Including Dravet Syndrome and Lennox-Gastaut Syndrome

  NCT03936777

  Conditions:   Dravet Syndrome;   Lennox Gastaut Syndrome;   Epileptic Encephalopathy
  Intervention:   Drug: ZX008 (Fenfluramine Hydrochloride)
  Sponsors:   Zogenix, Inc.;   Zogenix International Limited, Inc., a subsidiary of Zogenix, Inc.
  Enrolling by invitation
• Statins in Children With Type 1 Diabetes and Hypercholesterolemia

  NCT01236365

  Conditions:   Diabetes Mellitus, Insulin-Dependent;   Hypercholesterolemia
  Interventions:   Drug: Atorvastatin;   Drug: Atorvastatin Placebo
  Sponsors:   Nemours Children's Clinic;   Pfizer;   Medtronic;   Quest Diagnostics
  Completed
• Objective Brain Function Assessment of mTBI/Concussion

  NCT03963804

  Conditions:   Brain Injuries, Traumatic;   Concussion, Mild;   Concussion, Intermediate;   Concussion, Severe;   Concussion, Brain
  Intervention:   Device: BrainScope Ahead 300iP
  Sponsor:   BrainScope Company, Inc.
  Completed
• PRC-063 Classroom Study in Children (6-12 Years of Age) With ADHD

  NCT03172481

  Condition:   ADHD
  Interventions:   Drug: PRC-063 oral capsules;   Drug: Placebo oral capsules
  Sponsor:   Purdue Pharma, Canada
  Completed
• Protocol to Monitor the Neurological Development of Infants With Exposure in Utero From Birth to 15 Months in Tanezumab Clinical Studies

  NCT03031938

  Conditions:   Osteoarthritis;   Cancer Pain;   Recurrent Low Back Pain
  Intervention:   Drug: Investigational medical product (IMP) administered in parent study
  Sponsors:   Pfizer;   Eli Lilly and Company
  Active, not recruiting
• Study of the IDO Pathway Inhibitor, Indoximod, and Temozolomide for Pediatric Patients With Progressive Primary Malignant Brain Tumors

  NCT02502708

  Conditions:   Glioblastoma Multiforme;   Glioma;   Gliosarcoma;   Malignant Brain Tumor;   Ependymoma;   Medulloblastoma;   Diffuse Intrinsic Pontine Glioma;   Primary CNS Tumor
  Interventions:   Drug: Indoximod;   Drug: Temozolomide;   Radiation: Conformal Radiation;   Drug: Cyclophosphamide;   Drug: Etoposide
  Sponsor:   NewLink Genetics Corporation
  Recruiting
• Robotic vs. Freehand Corrective Surgery for Pediatric Scoliosis

  NCT02084264

  Condition:   Scoliosis
  Intervention:  
  Sponsor:   Mazor Robotics
  Terminated
• An Extension Study for Treatment of Moderately to Severely Active Ulcerative Colitis

  NCT03950232

  Condition:   Ulcerative Colitis
  Intervention:   Drug: Etrasimod
  Sponsor:   Arena Pharmaceuticals
  Recruiting
• Expanded Indications in the MED-EL Pediatric Cochlear Implant Population

  NCT03900897

  Condition:   Hearing Loss, Sensorineural
  Intervention:   Device: MED-EL SYNCHRONY PIN Cochlear Implant
  Sponsor:   Med-El Corporation
  Recruiting
• A Study to Assess the Efficacy, Safety, and Tolerability of Cannabidiol Oral Solution With Vigabatrin as Initial Therapy in Participants With Infantile Spasms

  NCT03421496

  Condition:   Infantile Spasm
  Interventions:   Drug: Cannabidiol Oral Solution;   Drug: Placebo;   Drug: Vigabatrin
  Sponsor:   INSYS Therapeutics Inc
  Active, not recruiting
• A Study of Lymphoseek® as a Lymphoid Tissue Targeting Agent in Pediatric Patients With Melanoma, Rhabdomyosarcoma, or Other Solid Tumors Who Are Undergoing Lymph Node Mapping

  NCT02509598

  Conditions:   Rhabdomyosarcoma;   Melanoma
  Interventions:   Drug: Tc99m tilmanocept;   Drug: Vital Blue Dye (optional)
  Sponsor:   Cardinal Health 414, LLC
  Completed
• Gastrointestinal Tract Microbiome in Healthy Term Infants Receiving Mother'S-own Breast Milk or Cow's Milk-based Infant Formulas

  NCT04059666

  Condition:   Gastrointestinal Microbiome
  Interventions:   Other: Investigational;   Other: Control
  Sponsor:   Mead Johnson Nutrition
  Recruiting
• iKanEat: A Randomized-controlled, Multi-center Trial of Megestrol for Chronic Oral Food Refusal in Children

  NCT03815019

  Conditions:   Feeding Behavior;   Feeding Disorder of Infancy or Early Childhood
  Interventions:   Drug: Megestrol Acetate;   Behavioral: iKanEat Behavioral Intervention
  Sponsor:   University of Kansas Medical Center
  Recruiting
• Study to Evaluate Dupilumab Monotherapy in Pediatric Patients With Peanut Allergy

  NCT03793608

  Condition:   Peanut Allergy
  Interventions:   Drug: Dupilumab;   Drug: placebo matching dupilumab
  Sponsor:   Regeneron Pharmaceuticals
  Recruiting
• Standard Lipid Therapy vs IVFE Minimization for Prevention of PNALD

  NCT02357576

  Condition:   Cholestasis
  Intervention:   Drug: Intralipid 20% I.V. Fat Emulsion
  Sponsors:   University of Michigan;   Seattle Children's Hospital;   University of Florida;   Primary Children's Hospital;   University of Colorado, Denver
  Terminated
• eHealth Evidence-based Intervention (EBI) for Latino Youth in Primary Care

  NCT03009539

  Conditions:   Sexual Risk Behavior;   Drug Use;   Family Functioning
  Intervention:   Behavioral: eHealth Familias Unidas Primary Care
  Sponsors:   University of Miami;   National Institute on Drug Abuse (NIDA)
  Active, not recruiting
• Type 1 Diabetes and the Brain in Children

  NCT02351466

  Condition:   Diabetes Mellitus, Type 1
  Intervention:   Other: Observational
  Sponsors:   Nemours Children's Clinic;   Stanford University;   Washington University School of Medicine;   Yale University;   University of Iowa
  Completed
• A Study to Test if TEV-50717 is Effective in Relieving Tics Associated With Tourette Syndrome

  NCT03571256

  Condition:   Tourette Syndrome
  Interventions:   Drug: deutetrabenazine Low;   Drug: deutetrabenazine High;   Drug: Placebo
  Sponsors:   Teva Branded Pharmaceutical Products, R&D Inc.;   Nuvelution TS Pharma, Inc.
  Recruiting
• Efficacy and Safety of Plecanatide in Children 6 to <18 Years of Age With Irritable Bowel Syndrome With Constipation (IBS-C)

  NCT03596905

  Condition:   Irritable Bowel Syndrome With Constipation
  Interventions:   Drug: Plecanatide;   Drug: Matching placebo
  Sponsor:   Bausch Health Americas, Inc.
  Recruiting
• A Study of Galcanezumab (LY2951742) in Participants 6 to 17 Years of Age With Episodic Migraine

  NCT03432286

  Condition:   Episodic Migraine
  Interventions:   Drug: Galcanezumab;   Drug: Placebo
  Sponsor:   Eli Lilly and Company
  Recruiting
• Evaluate the Safety of a Single Oral Dose of Solosec™ (Secnidazole) 2g for the Treatment of Adolescent Girls With BV

  NCT03937869

  Condition:   Bacterial Vaginoses
  Intervention:   Drug: Secnidazole
  Sponsor:   Lupin Research Inc
  Recruiting
• Effects of a Orally Inhaled Fluticasone Furoate on Growth Velocity in Prepubertal, Paediatric Subjects With Asthma Over a Year

  NCT02889809

  Condition:   Asthma
  Interventions:   Drug: Fluticasone furoate;   Drug: Placebo;   Drug: Montelukast;   Drug: Short Acting Beta 2 Agonist
  Sponsor:   GlaxoSmithKline
  Recruiting
• IBP-9414 for the Prevention of Necrotizing Enterocolitis - The Connection Study

  NCT03978000

  Condition:   Necrotizing Enterocolitis
  Interventions:   Drug: IBP-9414;   Drug: Placebo
  Sponsor:   Infant Bacterial Therapeutics
  Recruiting
• KP415 Open-Label Safety Study in Children (6-12 Years of Age) With ADHD

  NCT03460652

  Condition:   ADHD
  Intervention:   Drug: KP415 oral capsule
  Sponsor:   KemPharm, Inc.
  Completed
• JAK1 Inhibitor With Medicated Topical Therapy in Adolescents With Atopic Dermatitis

  NCT03796676

  Condition:   Atopic Dermatitis
  Interventions:   Drug: Placebo;   Drug: PF-04965842;   Drug: PF04965842
  Sponsor:   Pfizer
  Recruiting
• Immunogenicity and Safety of a Quadrivalent Meningococcal Conjugate Vaccine When Administered Concomitantly With Routine Pediatric Vaccines in Healthy Infants and Toddlers in the US

  NCT03537508

  Condition:   Meningococcal Infections
  Interventions:   Biological: MenACYW conjugate vaccine;   Biological: MenACYW-135 conjugate vaccine;   Biological: DTaP-IPV//Hib vaccine;   Biological: Pneumococcal 13-valent conjugate vaccine;   Biological: Pentavalent rotavirus vaccine;   Biological: Hepatitis B vaccine;   Biological: Measles, mumps, rubella (MMR) vaccine;   Biological: Varicella vaccine;   Biological: Hepatitis A vaccine
  Sponsor:   Sanofi Pasteur, a Sanofi Company
  Recruiting