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• tSCI Contrast Enhanced Ultrasound Study

  NCT04056988

  Condition:   Acute Spinal Cord Injury
  Intervention:   Drug: Perflutren Lipid Microsphere
  Sponsor:   University of Washington
  Recruiting
• Comparison of Transcutaneous and Epidural Spinal Stimulation for Improving Function

  NCT04043715

  Conditions:   Spinal Cord Injuries;   Spinal Cord Diseases;   Central Nervous System Diseases;   Nervous System Diseases;   Trauma, Nervous System;   Wounds and Injuries
  Interventions:   Device: Transcutaneous spinal stimulation;   Device: Epidural spinal stimulation
  Sponsors:   University of Washington;   U.S. National Science Foundation
  Recruiting
• Online Prenatal Trial in Mindfulness Sleep Management

  NCT04016428

  Conditions:   Pregnancy Related;   Insomnia;   Depression
  Interventions:   Behavioral: OPTIMISM;   Behavioral: Sleep Education
  Sponsors:   University of Washington;   National Institute of Nursing Research (NINR)
  Recruiting
• Validation of Diagnostics to Identify Glucose-6-phosphate Dehydrogenase Activity in the US

  NCT04010695

  Condition:   G6PD Deficiency
  Intervention:   Diagnostic Test: STANDARD G6PD
  Sponsors:   PATH;   Fred Hutchinson Cancer Research Center
  Recruiting
• Veterans Nature Therapy (Vet Hike)

  NCT03997344

  Condition:   Posttraumatic Stress Disorders
  Interventions:   Behavioral: Group nature hikes;   Behavioral: Group urban hikes
  Sponsors:   University of Washington;   VA Puget Sound Health Care System;   Recreational Equipment, Inc. (REI)
  Recruiting
• Harm Reduction for Tobacco Smoking With Support of Tobacco-Replacing Electronic Nicotine Delivery Systems

  NCT03962660

  Condition:   Smoking, Tobacco
  Interventions:   Other: HaRTS-TRENDS;   Other: Standard Care (SC)
  Sponsors:   University of Washington;   Downtown Emergency Service Center;   Washington State University
  Recruiting
• Validation of Consumer Activity Monitors in Postoperative Total Arthroplasty Patients

  NCT03958370

  Conditions:   Arthropathy of Knee;   Arthritis Knee;   Arthritis, Degenerative
  Intervention:   Other: Fitbit
  Sponsors:   Benaroya Research Institute;   Virginia Mason Hospital/Medical Center
  Recruiting
• Dental Hygiene and Peri-Implant Tissues Homeostasis Ancillary Study

  NCT03917264

  Condition:   Peri-Implantitis
  Interventions:   Procedure: Peri-implantitis debridement;   Other: Dental hygiene procedures
  Sponsors:   University of Washington;   Royalty Research Fund - University of Washington
  Recruiting
• Living in Full Even (LIFE) With Pain Study

  NCT03916276

  Conditions:   Musculoskeletal Pain;   Chronic Pain
  Interventions:   Behavioral: Cognitive Therapy (CT);   Behavioral: Mindfulness Meditation (MM);   Behavioral: Activation Skills (AS)
  Sponsors:   University of Washington;   National Center for Complementary and Integrative Health (NCCIH)
  Recruiting
• Modified Immune Cells (Autologous CAR T Cells) in Treating Patients With Advanced, Recurrent Platinum Resistant Ovarian, Fallopian Tube or Primary Peritoneal Cancer

  NCT03907527

  Conditions:   Platinum-Resistant Fallopian Tube Carcinoma;   Platinum-Resistant Ovarian Carcinoma;   Platinum-Resistant Primary Peritoneal Carcinoma;   Progressive Disease;   Recurrent Fallopian Tube Carcinoma;   Recurrent Ovarian Carcinoma;   Recurrent Primary Peritoneal Carcinoma;   Refractory Fallopian Tube Carcinoma;   Refractory Ovarian Carcinoma;   Refractory Primary Peritoneal Carcinoma;   Stage III Fallopian Tube Cancer AJCC v8;   Stage III Ovarian Cancer AJCC v8;   Stage III Primary Peritoneal Cancer AJCC v8;   Stage IIIA Fallopian Tube Cancer AJCC v8;   Stage IIIA Ovarian Cancer AJCC v8;   Stage IIIA Primary Peritoneal Cancer AJCC v8;   Stage IIIA1 Fallopian Tube Cancer AJCC v8;   Stage IIIA1 Ovarian Cancer AJCC v8;   Stage IIIA2 Fallopian Tube Cancer AJCC v8;   Stage IIIA2 Ovarian Cancer AJCC v8;   Stage IIIB Fallopian Tube Cancer AJCC v8;   Stage IIIB Ovarian Cancer AJCC v8;   Stage IIIB Primary Peritoneal Cancer AJCC v8;   Stage IIIC Fallopian Tube Cancer AJCC v8;   Stage IIIC Ovarian Cancer AJCC v8;   Stage IIIC Primary Peritoneal Cancer AJCC v8;   Stage IV Fallopian Tube Cancer AJCC v8;   Stage IV Ovarian Cancer AJCC v8;   Stage IV Primary Peritoneal Cancer AJCC v8;   Stage IVA Fallopian Tube Cancer AJCC v8;   Stage IVA Ovarian Cancer AJCC v8;   Stage IVA Primary Peritoneal Cancer AJCC v8;   Stage IVB Fallopian Tube Cancer AJCC v8;   Stage IVB Ovarian Cancer AJCC v8;   Stage IVB Primary Peritoneal Cancer AJCC v8
  Intervention:   Biological: PRGN-3005 UltraCAR-T cells
  Sponsors:   Fred Hutchinson Cancer Research Center;   National Cancer Institute (NCI);   Precigen, Inc
  Recruiting
• Adherence and Perspiration While Wearing Lower Limb Prostheses

  NCT03900845

  Condition:   Lower Extremity Amputation
  Interventions:   Device: Dynamic Air Exchange - Rising Edge Design (DAE-RED);   Device: Perforated elastomeric liner;   Device: As-prescribed prosthesis
  Sponsors:   Seattle Institute for Biomedical and Clinical Research;   United States Department of Defense
  Recruiting
• Management of Pleural Space Infections

  NCT03873766

  Conditions:   Empyema, Pleural;   Parapneumonic Effusion
  Interventions:   Drug: Intrapleural Medications;   Procedure: Surgery;   Procedure: Pleural Sampling;   Procedure: Pleural fluid drainage;   Radiation: Protocol Image #1;   Other: Surgical Consultation;   Radiation: Protocol Image #2: Chest X-ray PA/Lateral;   Behavioral: Quality of Life
  Sponsor:   Swedish Medical Center
  Recruiting
• Self-Management Interventions for Chronic Pain Relief With Cancer Survivors

  NCT03867760

  Condition:   Chronic Pain
  Interventions:   Behavioral: Recorded Hypnosis Intervention;   Behavioral: Recorded Relaxation Intervention
  Sponsors:   University of Washington;   National Institute of Nursing Research (NINR)
  Recruiting
• Intramuscular Mechanisms of Androgen Deprivation-related Sarcopenia

  NCT03867357

  Conditions:   Metastatic Prostate Cancer;   Androgen Deprivation Therapy
  Intervention:   Drug: GnRH agonist
  Sponsors:   Seattle Institute for Biomedical and Clinical Research;   United States Department of Defense;   University of Washington
  Recruiting
• The Efficacy of Hypnotic Cognitive Therapy for Chronic Pain in SCI

  NCT03857672

  Conditions:   Spinal Cord Injuries;   Chronic Pain
  Intervention:   Behavioral: Hypnotic Cognitive Therapy (HYPNOCT)
  Sponsors:   University of Washington;   The Craig H. Neilsen Foundation
  Recruiting
• TAP Blocks vs. IV Lidocaine for Kidney Transplants

  NCT03843879

  Condition:   Postoperative Pain
  Interventions:   Procedure: Transversus Abdominis Plane Block;   Drug: Intravenous Lidocaine
  Sponsor:   Benaroya Research Institute
  Recruiting
• Poststroke Depression in Hemorrhagic Stroke

  NCT03826875

  Conditions:   Stroke Hemorrhagic;   Depression
  Interventions:   Drug: Fluoxetine;   Drug: Placebo
  Sponsor:   University of Washington
  Recruiting
• Feasibility of Partners in Care Program for Caregivers of Patients With Acute Myeloid Leukemia

  NCT03806192

  Conditions:   Acute Myeloid Leukemia;   Caregiver
  Interventions:   Behavioral: Telephone-Based Intervention;   Other: Behavioral, Psychological or Informational Intervention;   Other: Questionnaire Administration
  Sponsors:   University of Washington;   National Cancer Institute (NCI)
  Recruiting
• Effects of SGLT-2 Inhibition on Myocardial Fibrosis and Inflammation as Assessed by Cardiac MRI in Patients With DM2

  NCT03782259

  Conditions:   Type 2 Diabetes Mellitus;   Myocardial Fibrosis;   Myocardial Inflammation
  Interventions:   Drug: dapagliflozin;   Other: Placebo
  Sponsors:   University of Washington;   AstraZeneca
  Recruiting
• Pilot Trial of Resistant Starch in Stage II-III Colorectal Cancer Survivors

  NCT03781778

  Conditions:   Colon Cancer;   Rectal Cancer
  Interventions:   Other: Dietary Intervention (resistant starch);   Other: Dietary Intervention (regular starch);   Other: Questionnaire Administration
  Sponsors:   Fred Hutchinson Cancer Research Center;   National Cancer Institute (NCI)
  Recruiting
• Acute Exercise Intervention in Reducing Breast Cancer Risk in Healthy Participants

  NCT03779867

  Conditions:   Healthy Subject;   Breast Cancer Female
  Interventions:   Behavioral: Exercise Intervention;   Other: Resting;   Other: Biomarker Analysis;   Other: Questionnaire Administration
  Sponsors:   Fred Hutchinson Cancer Research Center;   National Cancer Institute (NCI)
  Recruiting
• Nivolumab and Ipilimumab and Stereotactic Body Radiation Therapy in Treating Patients With Salivary Gland Cancers

  NCT03749460

  Conditions:   Larynx;   Lip;   Oral Cavity Cancer;   Pharynx Cancer
  Interventions:   Biological: Nivolumab;   Biological: Ipilimumab;   Radiation: Stereotactic Body Radiation Therapy
  Sponsor:   University of Washington
  Recruiting
• Gene-Modified Immune Cells (FH-MCVA2TCR) in Treating Patients With Metastatic or Unresectable Merkel Cell Cancer

  NCT03747484

  Condition:   Other Skin
  Interventions:   Biological: Autologous MCPyV-specific HLA-A02-restricted TCR-transduced CD4+ and CD8+ T-cells FH-MCVA2TCR;   Drug: Avelumab;   Radiation: Radiation Therapy
  Sponsors:   Fred Hutchinson Cancer Research Center;   National Cancer Institute (NCI);   Bluebird Biosciences
  Recruiting
• Healthy Aging Resources to Thrive (HART)

  NCT03739762

  Condition:   Sedentary Lifestyle
  Interventions:   Behavioral: i-STAND;   Other: Healthy Living control
  Sponsors:   Kaiser Permanente;   National Heart, Lung, and Blood Institute (NHLBI)
  Recruiting
• Occupational Therapist-Led Work Intervention in Facilitating Work Maintenance or Re-entry to the Workforce in Patients With Stage I to III Breast Cancer Undergoing Chemotherapy

  NCT03723863

  Conditions:   Breast Cancer Stage I;   Breast Cancer Stage III;   Breast Cancer Stage II;   Breast Cancer Stage IIA;   Breast Cancer Stage IIB;   Breast Cancer Stage IIIA;   Breast Cancer Stage IIIB;   Breast Cancer Stage IIIc;   Breast Cancer
  Intervention:   Behavioral: Occupational Therapy
  Sponsor:   University of Washington
  Recruiting
• Facilitating Communication Study

  NCT03721952

  Conditions:   Chronic Disease;   Neoplasm Metastasis;   Lung Neoplasm;   Pulmonary Disease, Chronic Obstructive;   Heart Failure, Congestive;   Liver Cirrhosis;   Kidney Failure, Chronic;   Multiple Organ Failure;   Health Care Quality, Access, and Evaluation;   Intensive Care Units;   Palliative Care, Health Services;   Palliative Care, Patient Care;   Lung Diseases, Interstitial
  Intervention:   Behavioral: Facilitator-Based Intervention
  Sponsor:   University of Washington
  Recruiting
• 211At-BC8-B10 and Donor Stem Cell Transplant in Treating Relapsed or Refractory AML, ALL, or Myelodysplastic Syndrome

  NCT03670966

  Conditions:   Acute Lymphoblastic Leukemia in Remission;   Acute Myeloid Leukemia in Remission;   Chronic Myelomonocytic Leukemia;   Myeloproliferative Neoplasm, Unclassifiable
  Interventions:   Biological: Astatine At 211 Anti-CD45 Monoclonal Antibody BC8-B10;   Drug: Fludarabine;   Drug: Cyclophosphamide;   Radiation: Total-Body Irradiation;   Procedure: Peripheral Blood Stem Cell Transplantation;   Procedure: Bone Marrow Transplantation;   Drug: Tacrolimus;   Drug: Mycophenolate Mofetil;   Drug: Sirolimus;   Biological: Granulocyte Colony-Stimulating Factor
  Sponsors:   Fred Hutchinson Cancer Research Center;   National Cancer Institute (NCI)
  Recruiting
• Nanoparticle Albumin-Bound Rapamycin and Pazopanib Hydrochloride in Patients With Nonadipocytic Soft Tissue Sarcomas

  NCT03660930

  Condition:   Soft Tissue Sarcoma
  Interventions:   Drug: Nanoparticle Albumin-Bound Rapamycin;   Drug: Pazopanib hydrochloride
  Sponsor:   University of Washington
  Recruiting
• The Effects of Moderate Exercise on Distress, Quality of Life, and Biomarkers of Angiogenesis and Chronic Stress in Ovarian Cancer Survivors

  NCT03641287

  Conditions:   Ovarian Cancer;   Fallopian Tube Adenocarcinoma;   Fallopian Tube Adenosarcoma;   Fallopian Tube Carcinosarcoma;   Fallopian Tube Clear Cell Adenocarcinoma;   Fallopian Tube Endometrioid Adenocarcinoma;   Fallopian Tube Mucinous Adenocarcinoma;   Fallopian Tube Serous Adenocarcinoma;   Fallopian Tube Transitional Cell Carcinoma;   Fallopian Tube Undifferentiated Carcinoma;   Malignant Ovarian Brenner Tumor;   Ovarian Adenocarcinoma;   Ovarian Adenosarcoma;   Ovarian Carcinosarcoma;   Ovarian Clear Cell Adenocarcinoma;   Ovarian Endometrioid Adenocarcinoma;   Ovarian Mucinous Adenocarcinoma;   Ovarian Seromucinous Carcinoma;   Ovarian Serous Adenocarcinoma;   Ovarian Transitional Cell Carcinoma;   Ovarian Undifferentiated Carcinoma;   Primary Peritoneal Serous Adenocarcinoma
  Interventions:   Other: Exercise Counseling;   Other: Aerobic Exercise;   Other: Physiological Support;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration;   Other: Best Practice
  Sponsor:   University of Washington
  Recruiting
• Genetic Influences on Response to Gait Rehabilitation in Parkinson's Disease

  NCT03607695

  Condition:   Parkinson's Disease
  Intervention:   Other: Gait training
  Sponsors:   VA Office of Research and Development;   University of Washington
  Recruiting
• CAMS Relational Agent System (CAMS-RAS) for Suicide Prevention

  NCT03584386

  Condition:   Suicide
  Intervention:   Device: V-CAMS
  Sponsors:   Evidence-Based Practice Institute, Seattle, WA;   University of Florida;   Mayo Clinic;   Allina Health;   Aurora Health Care;   Harborview Injury Prevention and Research Center;   The Catholic University of America
  Recruiting
• Enhanced E-cigarette Coaching Intervention for Dual Users of Cigarettes and E-cigarettes

  NCT03575468

  Condition:   Smoking Cessation
  Interventions:   Behavioral: Enhanced E-cigarette Coaching;   Behavioral: Quitline treatment as usual
  Sponsors:   Alere Wellbeing;   University of Oklahoma;   SRI International;   H. Lee Moffitt Cancer Center and Research Institute
  Recruiting
• Olaparib Before Surgery in Treating Participants With Localized Prostate Cancer

  NCT03570476

  Conditions:   ATM Biallelic Inactivation;   ATM Gene Mutation;   ATM Monoallelic Inactivation;   BRCA1 Biallelic Inactivation;   BRCA1 Gene Mutation;   BRCA2 Biallelic Inactivation;   BRCA2 Gene Mutation;   FANCA Biallelic Inactivation;   Homologous Recombination Deficiency;   PALB2 Biallelic Inactivation;   PALB2 Gene Mutation;   Prostate Adenocarcinoma Without Evidence of Neuroendocrine Differentiation;   Stage I Prostate Cancer AJCC v8;   Stage II Prostate Cancer AJCC v8;   Stage IIA Prostate Cancer AJCC v8;   Stage IIB Prostate Cancer AJCC v8;   Stage IIC Prostate Cancer AJCC v8
  Interventions:   Drug: Olaparib;   Procedure: Radical Prostatectomy
  Sponsors:   University of Washington;   National Cancer Institute (NCI)
  Recruiting
• Audio-visual Stimulation: Sleep Dose Response

  NCT03569865

  Conditions:   Insomnia Chronic;   Osteoarthritis;   Pain, Chronic
  Intervention:   Device: Audiovisual Stimulation
  Sponsor:   University of Washington
  Recruiting
• Repurposing a Histamine Antagonist to Benefit Patients With Pulmonary Hypertension

  NCT03554291

  Conditions:   Pulmonary Arterial Hypertension;   Right Heart Failure
  Interventions:   Drug: Famotidine 20 MG;   Other: Placebo
  Sponsors:   University of Washington;   National Heart, Lung, and Blood Institute (NHLBI)
  Recruiting
• Innovations in Dementia Empowerment and Action

  NCT03550131

  Conditions:   Alzheimer Disease;   Dementia
  Interventions:   Behavioral: Innovations in Dementia Empowerment and Action (IDEA);   Behavioral: Reducing Disabilities in Alzheimer's Disease (RDAD)
  Sponsor:   University of Washington
  Recruiting
• Predicting Responses to PTSD Treatment With Iris and Cardiovascular Tests

  NCT03539614

  Condition:   Posttraumatic Stress Disorder
  Interventions:   Drug: Prazosin;   Drug: Placebo
  Sponsor:   VA Office of Research and Development
  Recruiting
• Pivot-Flex Foot: Optimal Coupling Ratio Between Transverse and Sagittal-plane Motions Using a Torsionally Adaptive Prosthesis for Individuals With Lower Limb Amputation

  NCT03532100

  Condition:   Lower Extremity Amputation
  Interventions:   Device: Torsionally adaptive prosthesis with 0:1 coupling ratio;   Device: Torsionally adaptive prosthesis with 1:6 coupling ratio;   Device: Torsionally adaptive prosthesis with 1:4 coupling ratio;   Device: Torsionally adaptive prosthesis with 1:3 coupling ratio;   Device: Torsionally adaptive prosthesis with 1:2 coupling ratio
  Sponsor:   VA Office of Research and Development
  Recruiting
• Do Rocker Bottom Shoes and Ankle-Foot Orthoses Reduce Pain and Improve Mobility for Ankle Osteoarthritis Patients

  NCT03524729

  Conditions:   Ankle Osteoarthritis;   Healthy Ankles
  Interventions:   Device: Rocker bottom shoe;   Device: Ankle foot orthosis;   Device: Standard walking shoe
  Sponsor:   VA Office of Research and Development
  Recruiting
• Durvalumab, Tremelimumab and Stereotactic Body Radiation Therapy in Treating Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

  NCT03522584

  Conditions:   Metastatic Head and Neck Squamous Cell Carcinoma;   Recurrent Head and Neck Squamous Cell Carcinoma
  Interventions:   Biological: Durvalumab;   Other: Laboratory Biomarker Analysis;   Radiation: Stereotactic Body Radiation Therapy;   Biological: Tremelimumab
  Sponsors:   University of Washington;   National Cancer Institute (NCI)
  Recruiting
• Selecting Effective Combinations of Treatment for Low Back Pain

  NCT03520387

  Condition:   Low Back Pain
  Interventions:   Procedure: Lumbar medial branch nerve radiofrequency ablation (LRFA);   Procedure: Simulated LRFA with targeted steroid injections;   Behavioral: AcTIVE-CBT;   Behavioral: TBSCE
  Sponsor:   VA Office of Research and Development
  Recruiting
• CESM ABMR Breast Cancer Screening Trial

  NCT03517813

  Condition:   Breast Cancer Screening
  Intervention:   Device: Contrast-enhanced Spectral Mammography (CESM)
  Sponsor:   University of Washington
  Recruiting
• Testosterone and Olaparib in Treating Participants With Castration-Resistant Prostate Cancer

  NCT03516812

  Conditions:   Castration Levels of Testosterone;   Castration-Resistant Prostate Carcinoma;   Prostate Adenocarcinoma;   PSA Level Greater Than or Equal to One;   PSA Progression
  Interventions:   Other: Laboratory Biomarker Analysis;   Drug: Olaparib;   Other: Quality-of-Life Assessment;   Other: Survey Administration;   Drug: Testosterone Enanthate;   Drug: Testosterone Cypionate
  Sponsors:   University of Washington;   National Cancer Institute (NCI)
  Recruiting
• Stem Cell Transplant to Treat Patients With Favorable or Intermediate Risk Minimal Residual Disease Negative Acute Myeloid Leukemia

  NCT03515707

  Conditions:   Acute Myeloid Leukemia;   Minimal Residual Disease Negativity
  Interventions:   Procedure: Autologous Hematopoietic Stem Cell Transplantation;   Drug: Busulfan;   Drug: Etoposide;   Other: Laboratory Biomarker Analysis
  Sponsors:   Fred Hutchinson Cancer Research Center;   National Cancer Institute (NCI)
  Recruiting
• Genetic Testing for Men With Metastatic Prostate Cancer

  NCT03503097

  Conditions:   Metastatic Prostate Carcinoma;   Stage IV Prostate Cancer AJCC v8;   Stage IVB Prostate Cancer AJCC v8
  Interventions:   Procedure: Biospecimen Collection;   Other: Genetic Counseling;   Other: Genetic Testing;   Other: Laboratory Biomarker Analysis;   Behavioral: Questionnaire
  Sponsors:   University of Washington;   National Cancer Institute (NCI)
  Recruiting
• BCMA-Specific CAR T-Cells Combined With a Gamma Secretase Inhibitor (JSMD194) to Treat Relapsed or Persistent Multiple Myeloma

  NCT03502577

  Conditions:   Recurrent Plasma Cell Myeloma;   Refractory Plasma Cell Myeloma
  Interventions:   Biological: BCMA-specific CAR-expressing T Lymphocytes;   Drug: Cyclophosphamide;   Drug: Fludarabine;   Drug: Gamma-Secretase Inhibitor LY3039478;   Other: Laboratory Biomarker Analysis;   Other: Pharmacokinetic Study
  Sponsors:   Fred Hutchinson Cancer Research Center;   National Cancer Institute (NCI)
  Recruiting
• Pembrolizumab in Untreated B-Cell Non-Hodgkin Lymphoproliferative Diseases

  NCT03498612

  Conditions:   B-Cell Non-Hodgkin Lymphoma;   Follicular Lymphoma;   Indolent Non-Hodgkin Lymphoma;   Marginal Zone Lymphoma
  Interventions:   Other: Laboratory Biomarker Analysis;   Biological: Pembrolizumab
  Sponsors:   University of Washington;   National Cancer Institute (NCI)
  Recruiting
• MRI Characterization of Mammographically Detected DCIS

  NCT03495011

  Condition:   Breast Cancer, Stage 0
  Interventions:   Diagnostic Test: Breast MRI;   Other: Laboratory Biomarker Analysis
  Sponsors:   University of Washington;   National Cancer Institute (NCI)
  Recruiting
• Neutron Radiation Therapy and Pembrolizumab in Treating Participants With Advanced Urothelial Carcinoma

  NCT03486197

  Condition:   Urothelial Carcinoma
  Interventions:   Other: Laboratory Biomarker Analysis;   Biological: Pembrolizumab;   Radiation: Radiation Therapy
  Sponsors:   University of Washington;   National Cancer Institute (NCI)
  Recruiting
• A Prospective Trial of Virtual Home Rehabilitation After Burn Injury

  NCT03475654

  Conditions:   Burns;   Burn Scar;   Contracture
  Interventions:   Behavioral: Technology-assisted rehabilitation;   Behavioral: Usual care
  Sponsor:   University of Washington
  Recruiting
• Clinical Trial of Sodium Nitrite for Out of Hospital Cardiac Arrest

  NCT03452917

  Condition:   Out-Of-Hospital Cardiac Arrest
  Interventions:   Drug: Placebo;   Drug: sodium nitrite 45 mg;   Drug: sodium nitrite 60 mg
  Sponsors:   University of Washington;   National Heart, Lung, and Blood Institute (NHLBI)
  Recruiting
• Docetaxel, Carboplatin, and Rucaparib Camsylate in Treating Patients With Metastatic Castration Resistant Prostate Cancer With Homologous Recombination DNA Repair Deficiency

  NCT03442556

  Conditions:   ATM Gene Mutation;   BRCA1 Gene Mutation;   BRCA2 Gene Mutation;   Castration Levels of Testosterone;   Castration-Resistant Prostate Carcinoma;   Homologous Recombination Deficiency;   Prostate Carcinoma Metastatic in the Bone;   PSA Level Greater Than or Equal to Two;   PSA Progression;   Stage IV Prostate Adenocarcinoma AJCC v7
  Interventions:   Drug: Carboplatin;   Drug: Docetaxel;   Other: Laboratory Biomarker Analysis;   Drug: Rucaparib Camsylate
  Sponsors:   University of Washington;   National Cancer Institute (NCI)
  Recruiting
• Improving the Detection, Classification and Treatment of Misaligned Arthritic Ankles

  NCT03440008

  Condition:   Ankle Osteoarthritis
  Interventions:   Other: Dynamic 3D bone motion capture;   Device: wedged insole
  Sponsor:   VA Office of Research and Development
  Recruiting
• Microprocessor Knees in Early Rehabilitation

  NCT03433300

  Condition:   Amputation
  Interventions:   Device: Ottobock Kenevo/C-Leg;   Device: Ottobock 3R60/3R62
  Sponsors:   University of Washington;   United States Department of Defense;   Otto Bock Healthcare Products GmbH
  Recruiting
• Efficacy Trial of Stress Check-Up

  NCT03423394

  Condition:   Posttraumatic Stress Disorder
  Interventions:   Behavioral: Motivational Enhancement Therapy;   Behavioral: Treatment as Usual
  Sponsors:   University of Washington;   United States Department of Defense
  Recruiting
• Immune Changes Following Trabectedin in Patients With Metastatic or Unresectable Sarcoma

  NCT03397186

  Conditions:   Myxoid Liposarcoma;   Round Cell Liposarcoma;   Stage III Soft Tissue Sarcoma AJCC v7;   Stage IV Soft Tissue Sarcoma AJCC v7;   Metastatic Soft Tissue Sarcoma;   Unresectable Soft Tissue Sarcoma
  Interventions:   Procedure: Biopsy;   Other: Laboratory Biomarker Analysis;   Drug: Trabectedin
  Sponsors:   Fred Hutchinson Cancer Research Center;   National Cancer Institute (NCI);   Janssen Pharmaceuticals
  Recruiting
• High Throughput Drug Sensitivity and Genomics Data in Developing Individualized Treatment in Patients With Relapsed or Refractory Multiple Myeloma or Plasma Cell Leukemia

  NCT03389347

  Conditions:   Plasma Cell Leukemia;   Recurrent Plasma Cell Myeloma;   Refractory Plasma Cell Myeloma
  Interventions:   Procedure: Biospecimen Collection;   Device: High Throughput Screening;   Other: Laboratory Biomarker Analysis
  Sponsors:   University of Washington;   National Cancer Institute (NCI)
  Recruiting
• Dental Hygiene and Peri-Implant Tissues Homeostasis

  NCT03384446

  Condition:   Peri-Implantitis
  Interventions:   Other: Tooth-borne treatment;   Other: Implant-specific treatment
  Sponsors:   University of Washington;   Osteogenics Biomedical
  Recruiting
• Immunotherapy With BCMA CAR-T Cells in Treating Patients With BCMA Positive Relapsed or Refractory Multiple Myeloma

  NCT03338972

  Conditions:   Recurrent Plasma Cell Myeloma;   Refractory Plasma Cell Myeloma;   TNFRSF17 Positive
  Interventions:   Biological: Autologous Anti-BCMA-CAR-expressing CD4+/CD8+ T-lymphocytes FCARH143;   Drug: Cyclophosphamide;   Drug: Fludarabine;   Other: Laboratory Biomarker Analysis;   Procedure: Leukapheresis
  Sponsors:   Fred Hutchinson Cancer Research Center;   Juno Therapeutics, Inc.;   National Cancer Institute (NCI)
  Recruiting
• Doxorubicin Hydrochloride, Pembrolizumab, Vinblastine, and Dacarbazine in Treating Patients With Classical Hodgkin Lymphoma

  NCT03331341

  Condition:   Classical Hodgkin Lymphoma
  Interventions:   Drug: Dacarbazine;   Drug: Doxorubicin Hydrochloride;   Other: Laboratory Biomarker Analysis;   Biological: Pembrolizumab;   Drug: Vinblastine
  Sponsors:   University of Washington;   National Cancer Institute (NCI);   Merck Sharp & Dohme Corp.
  Recruiting
• Microgrid II - Electrocorticography Signals for Human Hand Prosthetics

  NCT03289572

  Condition:   Epilepsy Intractable
  Intervention:  
  Sponsor:   University of Washington
  Recruiting
• A Phase I/II Study to Evaluate the Safety of Cellular Immunotherapy Using Autologous T Cells Engineered to Express a CD20-Specific Chimeric Antigen Receptor for Patients With Relapsed or Refractory B Cell Non-Hodgkin Lymphomas

  NCT03277729

  Conditions:   CD20 Positive;   Recurrent B-Cell Non-Hodgkin Lymphoma;   Recurrent Chronic Lymphocytic Leukemia;   Recurrent Diffuse Large B-Cell Lymphoma;   Recurrent Follicular Lymphoma;   Recurrent Lymphoplasmacytic Lymphoma;   Recurrent Mantle Cell Lymphoma;   Recurrent Marginal Zone Lymphoma;   Refractory B-Cell Non-Hodgkin Lymphoma;   Refractory Diffuse Large B-Cell Lymphoma;   Refractory Follicular Lymphoma;   Refractory Lymphoplasmacytic Lymphoma;   Refractory Mantle Cell Lymphoma;   Refractory Transformed Non-Hodgkin Lymphoma;   Recurrent Transformed B-cell Non-Hodgkin Lymphoma;   Recurrent Transformed Chronic Lymphocytic Leukemia;   Refractory Marginal Zone Lymphoma;   Refractory Transformed B-cell Non-Hodgkin Lymphoma;   Refractory Transformed Chronic Lymphocytic Leukemia
  Interventions:   Biological: Chimeric Antigen Receptor T-Cell Therapy;   Drug: Cyclophosphamide;   Drug: Fludarabine;   Other: Laboratory Biomarker Analysis;   Procedure: Leukapheresis
  Sponsors:   Fred Hutchinson Cancer Research Center;   National Cancer Institute (NCI)
  Recruiting
• Panobinostat, Carfilzomib, and Dexamethasone in Patients With Relapsed or Refractory Multiple Myeloma

  NCT03256045

  Conditions:   Recurrent Plasma Cell Myeloma;   Refractory Plasma Cell Myeloma
  Interventions:   Drug: Carfilzomib;   Other: Chemosensitivity Assay;   Drug: Dexamethasone;   Other: Laboratory Biomarker Analysis;   Drug: Panobinostat
  Sponsors:   University of Washington;   National Cancer Institute (NCI)
  Recruiting
• Prazosin and CSF Biomarkers in mTBI

  NCT03221751

  Condition:   Dementia
  Interventions:   Drug: prazosin hydrochloride;   Drug: placebo
  Sponsor:   VA Office of Research and Development
  Recruiting
• 211^At-BC8-B10 Before Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome, or Mixed-Phenotype Acute Leukemia

  NCT03128034

  Conditions:   Acute Lymphoblastic Leukemia in Remission;   Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome;   Acute Myeloid Leukemia in Remission;   High Risk Myelodysplastic Syndrome;   Chronic Myelomonocytic Leukemia;   Myelodysplastic Syndrome With Excess Blasts;   Recurrent Acute Myeloid Leukemia;   Refractory Acute Lymphoblastic Leukemia;   Recurrent Acute Lymphoblastic Leukemia;   Recurrent Mixed Phenotype Acute Leukemia;   Refractory Acute Myeloid Leukemia;   Refractory Mixed Phenotype Acute Leukemia
  Interventions:   Drug: Cyclosporine;   Drug: Fludarabine Phosphate;   Other: Laboratory Biomarker Analysis;   Drug: Mycophenolate Mofetil;   Procedure: Peripheral Blood Stem Cell Transplantation;   Other: Pharmacological Study;   Radiation: Pretargeted Radioimmunotherapy;   Drug: Sirolimus;   Radiation: Total-Body Irradiation;   Device: Fludarabine
  Sponsors:   Fred Hutchinson Cancer Research Center;   National Cancer Institute (NCI)
  Recruiting
• TracelT Hydrogel in Localizing Bladder Tumors in Patients Undergoing Radiation Therapy for Bladder Cancer

  NCT03125226

  Condition:   Bladder Carcinoma
  Intervention:   Device: Polyethylene Glycol Hydrogel
  Sponsors:   University of Washington;   National Cancer Institute (NCI)
  Recruiting
• Genes Contributing to Hereditary Ovarian Cancer in Women and BRCA1/2 Wildtype Families

  NCT03119285

  Condition:   Ovarian Cancer
  Intervention:  
  Sponsor:   University of Washington
  Recruiting
• huJCAR014 CAR-T Cells in Treating Adult Patients With Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma or Acute Lymphoblastic Leukemia

  NCT03103971

  Conditions:   Adult B Acute Lymphoblastic Leukemia;   BCL2 Gene Rearrangement;   BCL6 Gene Rearrangement;   CD19 Positive;   Diffuse Large B-Cell Lymphoma, Not Otherwise Specified;   MYC Gene Rearrangement;   Recurrent Adult Acute Lymphoblastic Leukemia;   Recurrent B-Cell Non-Hodgkin Lymphoma;   Recurrent Diffuse Large B-Cell Lymphoma;   Recurrent Primary Mediastinal (Thymic) Large B-Cell Cell Lymphoma;   Refractory Adult Acute Lymphoblastic Leukemia;   Refractory B-Cell Non-Hodgkin Lymphoma;   Refractory Diffuse Large B-Cell Lymphoma;   Refractory Primary Mediastinal (Thymic) Large B-Cell Cell Lymphoma;   Recurrent Transformed Non-Hodgkin Lymphoma
  Interventions:   Biological: Autologous Human Anti-CD19CAR-4-1BB-CD3zeta-EGFRt-expressing CD4+/CD8+ T-lymphocytes;   Drug: Cyclophosphamide;   Drug: Fludarabine;   Other: Laboratory Biomarker Analysis;   Procedure: Leukapheresis;   Other: Pharmacological Study
  Sponsors:   Fred Hutchinson Cancer Research Center;   National Cancer Institute (NCI)
  Recruiting
• Avelumab and Trabectedin in Treating Patients With Liposarcoma or Leiomyosarcoma That is Metastatic or Cannot Be Removed by Surgery

  NCT03074318

  Conditions:   Metastatic Leiomyosarcoma;   Metastatic Liposarcoma;   Unresectable Leiomyosarcoma;   Unresectable Liposarcoma
  Interventions:   Drug: Avelumab;   Drug: Trabectedin
  Sponsors:   Fred Hutchinson Cancer Research Center;   National Cancer Institute (NCI)
  Recruiting
• Groups for Regaining Our Wellbeing

  NCT03058952

  Conditions:   Gulf War;   Fatigue;   Pain;   Depression
  Interventions:   Behavioral: Mindfulness-Based Stress Reduction;   Behavioral: Chronic Disease Self-Management Program
  Sponsor:   VA Office of Research and Development
  Recruiting
• HPV Vaccine Therapy in Interrupting Progression in Patients With High-Grade Vulvar or Anal Lesions

  NCT03051516

  Conditions:   High Grade Anal Canal Squamous Intraepithelial Neoplasia;   Vulvar High Grade Squamous Intraepithelial Lesion
  Interventions:   Other: Laboratory Biomarker Analysis;   Other: Placebo;   Other: Questionnaire Administration;   Biological: Recombinant Human Papillomavirus Nonavalent Vaccine
  Sponsors:   Fred Hutchinson Cancer Research Center;   National Cancer Institute (NCI)
  Recruiting
• Etoposide, Prednisone, Vincristine Sulfate, Cyclophosphamide, and Doxorubicin in Treating Patients With Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma

  NCT03023046

  Conditions:   Acute Lymphoblastic Leukemia;   Lymphoblastic Lymphoma;   Philadelphia Chromosome Positive
  Interventions:   Drug: Cyclophosphamide;   Drug: Dasatinib;   Drug: Doxorubicin;   Drug: Etoposide;   Drug: Imatinib Mesylate;   Other: Laboratory Biomarker Analysis;   Drug: Prednisone;   Biological: Rituximab;   Drug: Vincristine Sulfate
  Sponsors:   University of Washington;   National Cancer Institute (NCI)
  Recruiting
• Higher or Lower Dose Cladribine, Cytarabine, and Mitoxantrone in Treating Medically Less Fit Patients With Newly Diagnosed Acute Myeloid Leukemia or Myeloid Neoplasm

  NCT03012672

  Conditions:   Acute Leukemia of Ambiguous Lineage;   Acute Myeloid Leukemia;   Myeloid Neoplasm
  Interventions:   Drug: Cladribine;   Drug: Cytarabine;   Biological: Granulocyte Colony-Stimulating Factor;   Drug: Mitoxantrone Hydrochloride;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration
  Sponsors:   Fred Hutchinson Cancer Research Center;   National Cancer Institute (NCI)
  Recruiting
• Patient Fitness and Body Composition During Hematopoietic Stem Cell Transplantation

  NCT02990130

  Condition:   Hematologic Malignancy
  Intervention:   Other: Observational
  Sponsor:   Garcia, Jose M., MD, PhD
  Recruiting
• Metabolic and QOL Effects of GH Treatment in Patients With TBI and AGHD

  NCT02988687

  Condition:   Adult-Onset Growth Hormone Deficiency
  Intervention:  
  Sponsor:   Garcia, Jose M., MD, PhD
  Recruiting
• Strong Men, Strong Communities Diabetes Risk Reduction in American Indian Men

  NCT02953977

  Condition:   Diabetes
  Intervention:   Behavioral: Diabetes Prevention Program
  Sponsor:   Washington State University
  Recruiting
• Clearance of 25-hydroxyvitamin D in Chronic Kidney Disease

  NCT02937350

  Condition:   Chronic Kidney Disease
  Intervention:   Drug: D6-25-hydroxyvitamin D3
  Sponsors:   University of Washington;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
  Recruiting
• Short-Term Exposure for PTSD

  NCT02874898

  Conditions:   Chronic Post-Traumatic Stress Disorder;   Marijuana Abuse
  Intervention:   Behavioral: Brief Imaginal Exposure
  Sponsors:   University of Washington;   National Institute on Drug Abuse (NIDA)
  Recruiting
• Pembrolizumab in Treating Minimal Residual Disease in Patients With Acute Lymphoblastic Leukemia

  NCT02767934

  Conditions:   B Acute Lymphoblastic Leukemia;   Minimal Residual Disease;   Recurrent Acute Lymphoblastic Leukemia;   T Acute Lymphoblastic Leukemia
  Interventions:   Other: Laboratory Biomarker Analysis;   Biological: Pembrolizumab
  Sponsors:   University of Washington;   National Cancer Institute (NCI)
  Recruiting
• Early Allogeneic Hematopoietic Cell Transplantation in Treating Patients With Relapsed or Refractory High-Grade Myeloid Neoplasms

  NCT02756572

  Conditions:   Blasts 10 Percent or More of Bone Marrow Nucleated Cells;   Chronic Myelomonocytic Leukemia-2;   High Grade Malignant Neoplasm;   Myelodysplastic Syndrome;   Myelodysplastic Syndrome With Excess Blasts-2;   Myeloid Neoplasm;   Previously Treated Myelodysplastic Syndrome;   Recurrent Acute Myeloid Leukemia;   Refractory Acute Myeloid Leukemia
  Interventions:   Drug: Cladribine;   Drug: Cyclosporine;   Drug: Cytarabine;   Biological: Filgrastim;   Drug: Fludarabine Phosphate;   Procedure: Allogeneic Hematopoietic Stem Cell Transplantation;   Other: Laboratory Biomarker Analysis;   Drug: Melphalan;   Drug: Mitoxantrone Hydrochloride;   Drug: Mycophenolate Mofetil;   Other: Questionnaire Administration;   Drug: Sirolimus;   Radiation: Total-Body Irradiation;   Drug: Melphalan Hydrochloride
  Sponsors:   University of Washington;   National Cancer Institute (NCI)
  Recruiting
• JCAR014 and Durvalumab in Treating Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma

  NCT02706405

  Conditions:   BCL2 Gene Rearrangement;   BCL6 Gene Rearrangement;   CD19 Positive;   Diffuse Large B-Cell Lymphoma, Not Otherwise Specified;   High-Grade B-Cell Lymphoma With MYC, BCL2, and BCL6 Rearrangements;   MYC Gene Rearrangement;   Recurrent Diffuse Large B-Cell Lymphoma;   Recurrent Primary Mediastinal (Thymic) Large B-Cell Cell Lymphoma;   Refractory Diffuse Large B-Cell Lymphoma;   Refractory Primary Mediastinal (Thymic) Large B-Cell Cell Lymphoma
  Interventions:   Biological: Autologous Anti-CD19CAR-4-1BB-CD3zeta-EGFRt-expressing CD4+/CD8+ Central Memory T-lymphocytes JCAR014;   Drug: Cyclophosphamide;   Biological: Durvalumab;   Drug: Fludarabine Phosphate;   Other: Laboratory Biomarker Analysis;   Other: Pharmacological Study
  Sponsors:   Fred Hutchinson Cancer Research Center;   AstraZeneca;   Juno Therapeutics, Inc.;   MedImmune LLC;   National Cancer Institute (NCI)
  Recruiting
• Docetaxel and Carboplatin in Treating Patients With Metastatic, Castration Resistant Prostate Cancer Containing Inactivated Genes in the BRCA 1/2 Pathway

  NCT02598895

  Conditions:   Castration Levels of Testosterone;   Castration-Resistant Prostate Carcinoma;   Metastatic Prostate Carcinoma;   Prostate Carcinoma Metastatic in the Bone;   PSA Progression;   Stage IV Prostate Cancer
  Interventions:   Drug: Carboplatin;   Drug: Docetaxel;   Other: Laboratory Biomarker Analysis
  Sponsors:   University of Washington;   National Cancer Institute (NCI)
  Recruiting
• Continuous Glucose Monitoring During and After Surgery

  NCT02572856

  Condition:   Diabetes
  Intervention:   Device: Continuous Glucose Monitor (CGM)
  Sponsors:   University of Washington;   DexCom, Inc.
  Recruiting
• Sirolimus, Docetaxel, and Carboplatin in Treating Patients With Metastatic Castration-Resistant Prostate Cancer

  NCT02565901

  Conditions:   Castration Levels of Testosterone;   Castration-Resistant Prostate Carcinoma;   Metastatic Prostate Carcinoma;   Prostate Carcinoma Metastatic in the Bone;   PSA Level Greater Than or Equal to Two;   PSA Progression;   Stage IV Prostate Cancer AJCC v7
  Interventions:   Drug: Carboplatin;   Drug: Docetaxel;   Other: Laboratory Biomarker Analysis;   Drug: Sirolimus
  Sponsors:   University of Washington;   National Cancer Institute (NCI)
  Recruiting
• Diet and Exercise Program to Promote Weight Loss and Improve Health in Men With Low- or Low-Intermediate-Risk Prostate Cancer

  NCT02454517

  Conditions:   Obesity;   Overweight;   Prostate Adenocarcinoma;   Stage I Prostate Cancer AJCC V7;   Stage IIA Prostate Cancer AJCC v7
  Interventions:   Behavioral: Behavioral Dietary Intervention;   Behavioral: Exercise Intervention;   Other: Informational Intervention;   Other: Laboratory Biomarker Analysis;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration
  Sponsors:   Fred Hutchinson Cancer Research Center;   National Cancer Institute (NCI)
  Recruiting
• Ixazomib Citrate and Rituximab in Treating Patients With Indolent B-cell Non-Hodgkin Lymphoma

  NCT02339922

  Conditions:   Chronic Lymphocytic Leukemia;   Follicular Lymphoma;   Lymphoplasmacytic Lymphoma;   Mantle Cell Lymphoma;   Marginal Zone Lymphoma;   Recurrent Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue;   Refractory Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue;   Small Lymphocytic Lymphoma;   Waldenstrom Macroglobulinemia
  Interventions:   Drug: Ixazomib Citrate;   Other: Laboratory Biomarker Analysis;   Biological: Rituximab
  Sponsors:   University of Washington;   National Cancer Institute (NCI)
  Recruiting
• Stereotactic Body Radiotherapy for Stage I-III Prostate Cancer

  NCT02334579

  Conditions:   Prostate Cancer;   Prostatic Cancer;   Prostate Neoplasms;   Prostatic Neoplasms;   Cancer of the Prostate
  Intervention:   Radiation: CyberKnife Stereotactic Radiosurgery
  Sponsor:   Swedish Medical Center
  Recruiting
• Chronic Postconcussive Headache: A Placebo-Controlled Treatment Trial of Prazosin

  NCT02266329

  Conditions:   Posttraumatic Headache;   Combat Disorders;   Post Concussion Syndrome;   Headache;   Mild Traumatic Brain Injury;   Posttraumatic Migraine
  Interventions:   Drug: prazosin hydrochloride;   Drug: placebo
  Sponsor:   VA Office of Research and Development
  Recruiting
• JAK Inhibitor Before Donor Stem Cell Transplant in Treating Patients With Primary or Secondary Myelofibrosis

  NCT02251821

  Conditions:   Primary Myelofibrosis;   Secondary Myelofibrosis
  Interventions:   Procedure: Allogeneic Hematopoietic Stem Cell Transplantation;   Drug: Busulfan;   Drug: Cyclophosphamide;   Drug: Fludarabine Phosphate;   Other: Laboratory Biomarker Analysis;   Drug: Melphalan;   Drug: Methotrexate;   Drug: Mycophenolate Mofetil;   Drug: Ruxolitinib;   Drug: Tacrolimus;   Radiation: Total-Body Irradiation;   Procedure: Umbilical Cord Blood Transplantation
  Sponsors:   Fred Hutchinson Cancer Research Center;   National Cancer Institute (NCI);   National Heart, Lung, and Blood Institute (NHLBI)
  Recruiting
• Vaccine Therapy in Treating Patients With HER2-Negative Stage III-IV Breast Cancer

  NCT02157051

  Conditions:   HER2/Neu Negative;   Recurrent Breast Carcinoma;   Stage IIIA Breast Cancer;   Stage IIIB Breast Cancer;   Stage IIIC Breast Cancer;   Stage IV Breast Cancer;   Stage III Breast Cancer
  Interventions:   Biological: CD105/Yb-1/SOX2/CDH3/MDM2-polyepitope Plasmid DNA Vaccine;   Other: Laboratory Biomarker Analysis
  Sponsors:   University of Washington;   United States Department of Defense;   National Cancer Institute (NCI)
  Recruiting
• Branched Thoracic Endovascular Grafts for the Treatment of Thoraco-abdominal Aortic

  NCT01874197

  Condition:   Thoracoabdominal Aortic Aneurysm, Without Rupture
  Intervention:   Device: B-TEVAR device
  Sponsor:   University of Washington
  Recruiting
• Brentuximab Vedotin With or Without Nivolumab in Treating Patients With Relapsed or Refractory CD30+ Lymphoma

  NCT01703949

  Conditions:   CD30-Positive Neoplastic Cells Present;   Recurrent Hodgkin Lymphoma;   Recurrent Non-Hodgkin Lymphoma;   Refractory Hodgkin Lymphoma;   Refractory Non-Hodgkin Lymphoma
  Interventions:   Drug: Brentuximab Vedotin;   Other: Laboratory Biomarker Analysis;   Biological: Nivolumab
  Sponsors:   University of Washington;   National Cancer Institute (NCI)
  Recruiting
• Sulfur Colloid SPECT/CT in Measuring Liver Function in Patients With Primary or Metastatic Liver Cancer Undergoing Radiation Therapy or Surgery

  NCT02881554

  Conditions:   Hepatocellular Carcinoma;   Intrahepatic Cholangiocarcinoma;   Stage IV Liver Cancer;   Stage IVA Liver Cancer;   Stage IVB Liver Cancer;   Vascular Thrombosis
  Interventions:   Procedure: Computed Tomography;   Procedure: Single Photon Emission Computed Tomography;   Drug: Technetium Tc-99m Sulfur Colloid
  Sponsors:   University of Washington;   National Cancer Institute (NCI)
  Recruiting
• FLARE RT for Patients With Stage IIB-IIIB Non-small Cell Lung Cancer: Personalizing Radiation Therapy Using PET/CT and SPECT/CT Imaging

  NCT02773238

  Conditions:   Stage IIB Non-Small Cell Lung Carcinoma AJCC v7;   Stage IIIA Non-Small Cell Lung Cancer AJCC v7;   Stage IIIB Non-Small Cell Lung Cancer AJCC v7
  Interventions:   Procedure: Computed Tomography;   Radiation: Fludeoxyglucose F-18;   Other: Laboratory Biomarker Analysis;   Procedure: Positron Emission Tomography;   Radiation: Radiation Therapy;   Procedure: Single Photon Emission Computed Tomography;   Radiation: Technetium Tc-99m Albumin Aggregated;   Radiation: Technetium Tc-99m Sulfur Colloid
  Sponsors:   University of Washington;   National Cancer Institute (NCI)
  Recruiting
• High-Dose Y-90-Ibritumomab Tiuxetan Added to Reduced-Intensity Allogeneic Stem Cell Transplant Regimen for Relapsed or Refractory Aggressive B-Cell Lymphoma

  NCT01434472

  Conditions:   Post-Transplant Lymphoproliferative Disorder;   Recurrent Adult Diffuse Large Cell Lymphoma;   Recurrent B-Cell Non-Hodgkin Lymphoma;   Recurrent Burkitt Lymphoma;   Refractory B-Cell Non-Hodgkin Lymphoma;   Refractory Burkitt Lymphoma;   Refractory Diffuse Large B-Cell Lymphoma
  Interventions:   Procedure: Allogeneic Hematopoietic Stem Cell Transplantation;   Drug: Cyclosporine;   Drug: Fludarabine Phosphate;   Radiation: Indium In-111 Ibritumomab Tiuxetan;   Drug: Mycophenolate Mofetil;   Other: Pharmacological Study;   Biological: Rituximab;   Radiation: Total-Body Irradiation;   Radiation: Yttrium Y-90 Ibritumomab Tiuxetan;   Drug: Fludarabine
  Sponsors:   Fred Hutchinson Cancer Research Center;   National Cancer Institute (NCI)
  Recruiting
• Orthotic Dose Response Study

  NCT02629731

  Conditions:   Ankle Osteoarthritis;   Flat Foot or Pes Planus
  Intervention:   Device: custom orthoses with varying degrees of hindfoot posting
  Sponsors:   VA Office of Research and Development;   University of Washington
  Recruiting
• Optimization of Human Cortical Stimulation

  NCT01198964

  Conditions:   Epilepsy;   Brain Injury
  Intervention:   Procedure: Low-level cortical stimulation
  Sponsor:   University of Washington
  Recruiting
• Analysis of Tumors From Patients With Inherited Cancers Having Had Two Surgeries (Primary + Recurrent, or 2 Separate Types of Cancer)

  NCT01167842

  Conditions:   Breast Cancer;   Ovarian Cancer
  Intervention:  
  Sponsors:   University of Washington;   National Institutes of Health (NIH);   National Cancer Institute (NCI);   Fred Hutchinson Cancer Research Center
  Recruiting
• Vaccine Therapy in Preventing Cancer Recurrence in Patients With Non-Metastatic, Node Positive, HER2 Negative Breast Cancer That is in Remission

  NCT02780401

  Conditions:   HER2/Neu Negative;   No Evidence of Disease;   One or More Positive Axillary Nodes;   Stage IB Breast Cancer;   Stage II Breast Cancer;   Stage IIA Breast Cancer;   Stage IIB Breast Cancer;   Stage III Breast Cancer;   Stage IIIA Breast Cancer;   Stage IIIB Breast Cancer;   Stage IIIC Breast Cancer
  Interventions:   Other: Laboratory Biomarker Analysis;   Biological: pUMVC3-IGFBP2-HER2-IGF1R Plasmid DNA Vaccine;   Biological: Sargramostim
  Sponsors:   University of Washington;   National Cancer Institute (NCI);   University of Wisconsin, Madison
  Recruiting
• CISTO: Comparison of Intravesical Therapy and Surgery as Treatment Options for Bladder Cancer

  NCT03933826

  Conditions:   Bladder Cancer;   Cancer of the Bladder, Recurrent;   Non-muscle Invasive Bladder Cancer
  Intervention:  
  Sponsors:   University of Washington;   Patient-Centered Outcomes Research Institute
  Recruiting
• TR1801-ADC in Patients With Tumors That Express c-Met

  NCT03859752

  Condition:   Unspecified Adult Solid Tumor, Protocol Specific
  Intervention:   Biological: TR1801-ADC
  Sponsors:   Tanabe Research Laboratories USA Inc;   Open Innovation Partners
  Recruiting
• Trial of Adherence App for Buprenorphine Treatment (TAAB) Study

  NCT03779997

  Condition:   Opioid-Related Disorders
  Intervention:   Behavioral: Video-based DOT Application
  Sponsors:   University of Washington;   National Institute on Drug Abuse (NIDA);   emocha Mobile Health, Inc.
  Recruiting
• Trial of Azithromycin vs. Doxycycline for the Treatment of Rectal Chlamydia in MSM

  NCT03608774

  Condition:   Anal Chlamydia Infection
  Interventions:   Drug: Azithromycin;   Drug: Doxycycline;   Other: Placebo
  Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
  Recruiting
• A Lay-Led Intervention for War and Refugee Related Trauma

  NCT03502278

  Condition:   PTSD
  Intervention:   Behavioral: Islamic Trauma Healing
  Sponsors:   University of Washington;   National Institute of Mental Health (NIMH);   Seattle Pacific University;   Case Western Reserve University
  Recruiting
• Vaccine to Prevent Recurrence in Patients With HER-2 Positive Breast Cancer

  NCT03384914

  Conditions:   Breast Cancer Female;   Breast Cancer, Male;   Breast Cancer Stage I;   Breast Cancer Stage II;   Breast Cancer Stage III;   Residual Disease;   HER2-positive Breast Cancer;   HER2 Positive Breast Carcinoma
  Interventions:   Biological: DC1 Vaccine;   Biological: WOKVAC Vaccine
  Sponsors:   H. Lee Moffitt Cancer Center and Research Institute;   United States Department of Defense
  Recruiting
• Stand up to Cancer: MAGENTA (Making Genetic Testing Accessible)

  NCT02993068

  Conditions:   BARD1 Gene Mutation;   BRCA1 Gene Mutation;   BRCA2 Gene Mutation;   BRIP1 Gene Mutation;   Estrogen Receptor Negative;   HER2/Neu Negative;   MLH1 Gene Mutation;   MSH2 Gene Mutation;   MSH6 Gene Mutation;   PALB2 Gene Mutation;   PMS2 Gene Mutation;   Progesterone Receptor Negative;   RAD51C Gene Mutation;   RAD51D Gene Mutation;   Triple-Negative Breast Carcinoma
  Interventions:   Other: Educational Intervention;   Other: Genetic Counseling;   Other: Laboratory Biomarker Analysis;   Other: Questionnaire Administration
  Sponsors:   M.D. Anderson Cancer Center;   National Cancer Institute (NCI)
  Recruiting
• Apalutamide in Treating Patients With Prostate Cancer Who Are in Active Surveillance

  NCT02721979

  Conditions:   Prostate Adenocarcinoma;   Testosterone Greater Than or Equal to 150 ng/dL
  Interventions:   Drug: Apalutamide;   Other: Laboratory Biomarker Analysis;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration
  Sponsors:   University of Washington;   Janssen Scientific Affairs, LLC;   National Cancer Institute (NCI)
  Recruiting
• Advancing Symptom Alleviation With Palliative Treatment

  NCT02713347

  Conditions:   Heart Failure;   Pulmonary Disease, Chronic Obstructive;   Emphysema;   Pulmonary Fibrosis, Interstitial Lung Disease
  Intervention:   Behavioral: ADAPT Intervention
  Sponsor:   VA Office of Research and Development
  Recruiting
• Afatinib Dimaleate and Capecitabine in Treating Patients With Advanced Refractory Solid Tumors, Pancreatic Cancer or Biliary Cancer

  NCT02451553

  Conditions:   Advanced Malignant Solid Neoplasm;   Bile Duct Carcinoma;   Recurrent Malignant Solid Neoplasm;   Recurrent Pancreatic Carcinoma;   Stage III Pancreatic Cancer AJCC v6 and v7;   Stage IVA Pancreatic Cancer;   Stage IVB Pancreatic Cancer
  Interventions:   Drug: Afatinib Dimaleate;   Drug: Capecitabine;   Other: Laboratory Biomarker Analysis
  Sponsors:   University of Washington;   National Cancer Institute (NCI)
  Recruiting
• Aztreonam for Pharyngeal Gonorrhea

  NCT03867734

  Conditions:   Gonorrhea of Pharynx;   Gonorrhea
  Intervention:   Drug: Aztreonam
  Sponsor:   University of Washington
  Recruiting
• Yeego! Healthy Eating & Gardening

  NCT03778021

  Conditions:   Dietary Habits;   Health Behavior;   Eating Behavior
  Interventions:   Behavioral: Behavioral Gardening Exposure;   Behavioral: Healthy Eating and Gardening Curriculum;   Behavioral: Family Workshops
  Sponsor:   Fred Hutchinson Cancer Research Center
  Recruiting
• HA-1 T TCR T Cell Immunotherapy for the Treating of Patients With Relapsed or Refractory Acute Leukemia After Donor Stem Cell Transplant

  NCT03326921

  Conditions:   HLA-A*0201 HA-1 Positive Cells Present;   Juvenile Myelomonocytic Leukemia;   Recurrent Acute Biphenotypic Leukemia;   Recurrent Acute Undifferentiated Leukemia;   Recurrent Childhood Acute Lymphoblastic Leukemia;   Recurrent Childhood Acute Myeloid Leukemia;   Refractory Acute Lymphoblastic Leukemia;   Refractory Adult Acute Lymphoblastic Leukemia;   Allogeneic Hematopoietic Stem Cell Transplantation Recipient;   Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive;   Chronic Myelomonocytic Leukemia;   Donor;   Recurrent Blastic Plasmacytoid Dendritic Cell Neoplasm;   Recurrent Myelodysplastic Syndrome;   Refractory Blastic Plasmacytoid Dendritic Cell Neoplasm;   Refractory Myelodysplastic Syndrome;   Acute Undifferentiated Leukemia;   Blast Cells Present;   Blastic Plasmacytoid Dendritic Cell Neoplasm;   Blasts 5 Percent or More of Bone Marrow Nucleated Cells;   Minimal Residual Disease;   Mixed Phenotype Acute Leukemia;   Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive;   Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive;   Recurrent Acute Lymphoblastic Leukemia;   Recurrent Acute Myeloid Leukemia
  Interventions:   Biological: CD8+ and CD4+ Donor Memory T-cells-expressing HA1-Specific TCR;   Drug: Fludarabine;   Other: Laboratory Biomarker Analysis
  Sponsors:   Fred Hutchinson Cancer Research Center;   Alex's Lemonade Stand Foundation;   National Cancer Institute (NCI);   The Leukemia and Lymphoma Society
  Recruiting
• Comparison of Triple GVHD Prophylaxis Regimens for Nonmyeloablative or Reduced Intensity Conditioning Unrelated Mobilized Blood Cell Transplantation

  NCT03246906

  Conditions:   Acute Lymphoblastic Leukemia;   Acute Myeloid Leukemia;   Aggressive Non-Hodgkin Lymphoma;   Chronic Lymphocytic Leukemia;   Diffuse Large B-Cell Lymphoma;   Hematopoietic Cell Transplant Recipient;   Loss of Chromosome 17p;   Mantle Cell Lymphoma;   Myelodysplastic Syndrome;   Myelodysplastic/Myeloproliferative Neoplasm;   Prolymphocytic Leukemia;   Recurrent Chronic Lymphocytic Leukemia;   Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive;   Recurrent Hodgkin Lymphoma;   Recurrent Plasma Cell Myeloma;   Recurrent Small Lymphocytic Lymphoma;   Recurrent Waldenstrom Macroglobulinemia
  Interventions:   Procedure: Allogeneic Hematopoietic Stem Cell Transplantation;   Drug: Cyclophosphamide;   Drug: Cyclosporine;   Drug: Mycophenolate Mofetil;   Drug: Sirolimus
  Sponsors:   Fred Hutchinson Cancer Research Center;   National Cancer Institute (NCI)
  Recruiting
• Preventing HIV Among Native Americans Through the Treatment PTSD & Substance Use

  NCT03112369

  Condition:   HIV Prevention
  Interventions:   Behavioral: Narrative Exposure Therapy (NET);   Behavioral: Motivational Interviewing w/Skills Training (MIST)
  Sponsors:   University of Washington;   National Institute on Minority Health and Health Disparities (NIMHD)
  Recruiting
• VillageWhere: Innovative Mobile Technology for Youth With Conduct Disorder and Their Parents

  NCT03065517

  Condition:   Child Behavior Disorders
  Interventions:   Device: VillageWhere App;   Device: Attention-Control Placebo App
  Sponsors:   Evidence-Based Practice Institute, Seattle, WA;   National Institute of Mental Health (NIMH);   University of Maryland, College Park
  Recruiting
• H2O VR for Burns 2015

  NCT02729259

  Conditions:   Pain;   Burn
  Interventions:   Behavioral: Virtual Reality Snowworld;   Behavioral: Virtual Reality slides of nature;   Behavioral: Control standard nurse wound care
  Sponsors:   National Institute of General Medical Sciences (NIGMS);   University of Washington
  Recruiting
• Veteran Peer Coaches Optimizing and Advancing Cardiac Health

  NCT02697422

  Conditions:   Cardiovascular Disease (CVD);   Hypertension;   Hyperlipemia;   Obesity
  Intervention:   Other: Community-based peer health coach intervention
  Sponsor:   VA Office of Research and Development
  Recruiting
• Virtual Reality Water Friendly Wound Care

  NCT02646787

  Condition:   Pain
  Interventions:   Behavioral: Active Virtual Reality;   Behavioral: Passive Virtual Reality
  Sponsors:   University of Washington;   National Institutes of Health (NIH);   National Institute of General Medical Sciences (NIGMS);   University of Texas
  Recruiting
• High Throughput Drug Sensitivity Assay and Genomics- Guided Treatment of Patients With Relapsed or Refractory Acute Leukemia

  NCT02551718

  Conditions:   Acute Leukemia of Ambiguous Lineage;   Recurrent Adult Acute Lymphoblastic Leukemia;   Recurrent Adult Acute Myeloid Leukemia;   Recurrent Childhood Acute Lymphoblastic Leukemia;   Recurrent Childhood Acute Myeloid Leukemia;   Refractory Acute Myeloid Leukemia;   Refractory Adult Acute Lymphoblastic Leukemia;   Refractory Childhood Acute Lymphoblastic Leukemia
  Interventions:   Other: Chemosensitivity Assay;   Other: Cytology Specimen Collection Procedure;   Genetic: Gene Expression Analysis;   Genetic: Genetic Variation Analysis;   Drug: In Vitro Sensitivity-Directed Chemotherapy
  Sponsors:   University of Washington;   National Cancer Institute (NCI)
  Recruiting
• Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies

  NCT01028716

  Conditions:   Acute Biphenotypic Leukemia;   Acute Erythroid Leukemia in Remission;   Acute Leukemia in Remission;   Acute Lymphoblastic Leukemia in Remission;   Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome;   Acute Myeloid Leukemia in Remission;   Acute Myeloid Leukemia With FLT3/ITD Mutation;   Acute Myeloid Leukemia With Inv(3) (q21.3;q26.2); GATA2, MECOM;   Acute Myeloid Leukemia With Multilineage Dysplasia;   Acute Myeloid Leukemia With t(6;9) (p23;q34.1); DEK-NUP214;   Acute Undifferentiated Leukemia;   Adult Acute Lymphoblastic Leukemia in Complete Remission;   B Acute Lymphoblastic Leukemia With t(1;19)(q23;p13.3); E2A-PBX1 (TCF3-PBX1);   B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1;   Burkitt Lymphoma;   Childhood Acute Lymphoblastic Leukemia in Complete Remission;   DS Stage II Plasma Cell Myeloma;   DS Stage III Plasma Cell Myeloma;   Myelodysplastic Syndrome;   Recurrent Anaplastic Large Cell Lymphoma;   Blasts Under 5 Percent of Bone Marrow Nucleated Cells;   Recurrent Follicular Lymphoma;   Recurrent Hodgkin Lymphoma;   Recurrent Mantle Cell Lymphoma;   Recurrent Marginal Zone Lymphoma;   Recurrent Plasma Cell Myeloma;   Refractory Plasma Cell Myeloma;   Secondary Acute Myeloid Leukemia;   T Lymphoblastic Lymphoma;   Hematopoietic Cell Transplant Recipient
  Interventions:   Drug: Cyclophosphamide;   Biological: Filgrastim;   Drug: Fludarabine Phosphate;   Procedure: Laboratory Biomarker Analysis;   Drug: Mycophenolate Mofetil;   Procedure: Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation;   Procedure: Peripheral Blood Stem Cell Transplantation;   Drug: Tacrolimus;   Radiation: Total-Body Irradiation;   Drug: Fludarabine
  Sponsors:   Fred Hutchinson Cancer Research Center;   National Cancer Institute (NCI)
  Recruiting
• Diet Intervention for Hypertension: Adaptation and Dissemination to Native Communities

  NCT02796313

  Condition:   Hypertension
  Interventions:   Behavioral: DASH Groceries + Weekly Sessions;   Behavioral: Groceries + Brochure
  Sponsors:   Washington State University;   Oklahoma State University
  Recruiting
• Preventing Levodopa Induced Dyskinesia in Parkinson's Disease With HMG-CoA Reductase Inhibitors

  NCT04064294

  Conditions:   Parkinson Disease;   Dyskinesia, Drug-Induced
  Intervention:   Drug: Intravenous Infusion
  Sponsor:   Oregon Health and Science University
  Recruiting
• Optimizing a Mobile Mindfulness Intervention for ICU Survivors

  NCT04038567

  Condition:   Cardiorespiratory Failure
  Intervention:   Behavioral: Mobile mindfulness-based training
  Sponsors:   Duke University;   University of Washington;   University of Colorado, Denver;   National Center for Complementary and Integrative Health (NCCIH)
  Recruiting
• MRI Study of Infinity DBS System

  NCT03884231

  Conditions:   Movement Disorders;   Parkinson Disease;   Essential Tremor;   Tremor;   Dystonia
  Intervention:   Procedure: MRI imaging procedure
  Sponsor:   Abbott Medical Devices
  Recruiting
• FemPulse Therapy for Overactive Bladder in Women

  NCT03784170

  Condition:   Urinary Bladder, Overactive
  Intervention:   Device: FemPulse System
  Sponsor:   FemPulse Corporation
  Recruiting
• A Test-Drive Strategy for the Prescription of Prosthetic Feet for People With Leg Amputations

  NCT03651830

  Condition:   Amputation
  Interventions:   Device: Prosthetic Foot Emulator;   Device: Commercially available prosthetic feet
  Sponsors:   Seattle Institute for Biomedical and Clinical Research;   VA Puget Sound Health Care System;   Minneapolis Veterans Affairs Medical Center;   Brooke Army Medical Center;   Stanford University;   University of Washington
  Recruiting
• Inpatient Palliative Care for Patients Undergoing Hematopoietic Stem Cell Transplantation

  NCT03641378

  Condition:   Stem Cell Transplant
  Interventions:   Other: Palliative Care Intervention;   Other: Standard Transplant Care
  Sponsors:   Massachusetts General Hospital;   National Institutes of Health (NIH);   National Cancer Institute (NCI)
  Recruiting
• Promoting Smoking Cessation in Lung Cancer Screening Through Proactive Treatment

  NCT03612804

  Conditions:   Smoking Reduction;   Tobacco Use;   Tobacco Smoking;   Tomography;   Lung Diseases;   Lung Neoplasms
  Interventions:   Behavioral: Unsigned note to provider about cessation medication prescription;   Behavioral: Proactive Telephone Counseling from VA Quitline
  Sponsors:   VA Office of Research and Development;   Fred Hutchinson Cancer Research Center
  Recruiting
• CPX-351 (Vyxeos™) for Transplant Eligible, Higher Risk Patients With Myelodysplastic Syndrome

  NCT03572764

  Condition:   Myelodysplastic Syndromes
  Interventions:   Drug: CPX-351;   Procedure: Research skin biopsy;   Procedure: Research blood draw;   Procedure: Research bone marrow aspirate
  Sponsors:   Washington University School of Medicine;   Jazz Pharmaceuticals
  Recruiting
• Pembrolizumab Plus Y90 Radioembolization in HCC Subjects

  NCT03099564

  Condition:   Hepatocellular Carcinoma
  Interventions:   Drug: Pembrolizumab;   Device: Y90 radioembolization
  Sponsors:   Autumn McRee, MD;   Merck Sharp & Dohme Corp.;   Hoosier Cancer Research Network
  Recruiting
• Precise Local Injection of Anti-cancer Drugs Using Presage's CIVO™ Device in Soft Tissue Sarcoma

  NCT03056599

  Condition:   Soft Tissue Sarcoma Adult
  Interventions:   Drug: Multiple drug microinjection;   Device: CIVO device
  Sponsors:   Presage Biosciences;   Fred Hutchinson Cancer Research Center;   University of Washington;   Northwell Health;   Oregon Health and Science University
  Recruiting
• Alpers Huttenlocher Natural History Study

  NCT03034512

  Condition:   Alpers Huttenlocher Syndrome
  Intervention:  
  Sponsors:   Columbia University;   Seattle Children's Hospital;   National Institute of Neurological Disorders and Stroke (NINDS)
  Recruiting
• Study of Immunotherapy in Combination With Ublituximab and Umbralisib in Patients With Relapsed-refractory CLL or Richter's Transformation

  NCT02535286

  Conditions:   Chronic Lymphocytic Leukemia;   Richter Syndrome
  Interventions:   Drug: Umbralisib;   Biological: ublituximab;   Biological: TG-1501
  Sponsors:   TG Therapeutics, Inc.;   Memorial Sloan Kettering Cancer Center
  Recruiting
• Trial Comparing Relapse Rates Between Standard Ureteroscopic Removal Of Ureteral Stone And Standard Removal With Additional Ureterorenic Clearing Of Non-Symptomatic Stones In The Kidney

  NCT02210650

  Condition:   Ureteral Stones
  Interventions:   Procedure: Ureteral stone removal;   Procedure: Asymptomatic kidney stones and ureteral stone removed
  Sponsors:   Indiana Kidney Stone Institute;   University of Washington Medical Center Department of Urology (Seattle, WA);   VA Puget Sound Health Care System
  Recruiting
• Chemotherapy in Treating Patients With Myelodysplastic Syndrome Before Donor Stem Cell Transplant

  NCT01812252

  Conditions:   Chronic Myelomonocytic Leukemia;   de Novo Myelodysplastic Syndrome;   Myelodysplastic Syndrome;   Secondary Myelodysplastic Syndrome
  Interventions:   Drug: Azacitidine;   Drug: Decitabine;   Other: Quality-of-Life Assessment
  Sponsors:   Fred Hutchinson Cancer Research Center;   National Cancer Institute (NCI)
  Recruiting
• Carmustine, Etoposide, Cytarabine, Melphalan, and Antithymocyte Globulin Followed by Peripheral Blood Stem Cell Transplant in Treating Patients With Autoimmune Neurologic Disease That Did Not Respond to Previous Therapy

  NCT00716066

  Condition:   Autoimmune Disease
  Interventions:   Biological: Anti-Thymocyte Globulin;   Procedure: Autologous Hematopoietic Stem Cell Transplantation;   Drug: Carmustine;   Drug: Cytarabine;   Drug: Etoposide;   Other: Laboratory Biomarker Analysis;   Drug: Melphalan;   Procedure: Peripheral Blood Stem Cell Transplantation;   Drug: Prednisone;   Procedure: Syngeneic Bone Marrow Transplantation
  Sponsors:   Fred Hutchinson Cancer Research Center;   National Cancer Institute (NCI)
  Recruiting
• Communication During Hospitalization About Resuscitation Trial

  NCT02984124

  Conditions:   Severe Life-limiting COPD;   Severe Life-limiting Heart Failure;   Severe Life-limiting Cirrhosis;   Severe Life-limiting Malignancy;   Severe Functional Impairment
  Interventions:   Behavioral: Informed Assent Discussion;   Behavioral: Usual Care with Attention Control
  Sponsors:   University of Vermont;   University of Washington;   Medical University of South Carolina;   University of California, San Francisco
  Recruiting
• A Phase 1 Study to Evaluate SNDX- 6352 in Subjects With Active cGVHD

  NCT03604692

  Condition:   Chronic Graft-versus-host-disease
  Intervention:   Drug: SNDX-6352
  Sponsor:   Syndax Pharmaceuticals
  Recruiting
• Neurocognition in Congenital Central Hypoventilation Syndrome (CCHS)

  NCT03568669

  Conditions:   Congenital Central Hypoventilation Syndrome;   Congenital Central Hypoventilation;   CCHS;   CCHS With Hirschsprung Disease;   CCHS With Neural Crest Tumor;   CCHS With Neuroblastoma
  Intervention:   Other: NIH Toolbox Cognition Battery
  Sponsors:   Debra Weese-Mayer;   Ann & Robert H Lurie Children's Hospital of Chicago;   Seattle Children's Hospital;   Children's Hospital Los Angeles
  Recruiting
• Initial and Chronic Methicillin Resistant Staphylococcus Aureus (MRSA) Infection in Cystic Fibrosis (CF)

  NCT02684422

  Conditions:   Methicillin-Resistant Staphylococcus Aureus;   Cystic Fibrosis
  Intervention:   Other: Intervention N/A. Observational study
  Sponsor:   University of North Carolina, Chapel Hill
  Recruiting
• HSCT for Patients With Fanconi Anemia Using Risk-Adjusted Chemotherapy

  NCT02143830

  Conditions:   Fanconi Anemia;   Severe Marrow Failure;   Myelodysplastic Syndrome (MDS);   Acute Myelogenous Leukemia (AML)
  Interventions:   Drug: Busulfan;   Drug: Cyclophosphamide;   Drug: Fludarabine;   Drug: rabbit ATG;   Drug: G-CSF;   Biological: Peripheral blood stem cell
  Sponsors:   Children's Hospital Medical Center, Cincinnati;   Memorial Sloan Kettering Cancer Center;   Fred Hutchinson Cancer Research Center
  Recruiting
• Evaluation of Efficacy and Safety of Neoadjuvant Treatment With Pamrevlumab in Combination With Chemotherapy (Gemcitabine and Nab-paclitaxel) in Locally Advanced Pancreatic Cancer

  NCT03941093

  Condition:   Pancreatic Cancer Non-resectable
  Interventions:   Drug: Pamrevlumab + Gemcitabine + Nab-paclitaxel;   Drug: Placebo + Gemcitabine + Nab-paclitaxel
  Sponsor:   FibroGen
  Recruiting
• Impact of Physical Activity and Diet on Symptom Experience in People Living With HIV

  NCT03790501

  Condition:   HIV/AIDS
  Intervention:   Other: No intervention
  Sponsors:   Case Western Reserve University;   University of Alabama at Birmingham
  Recruiting
• A Safety Study of SEA-BCMA in Patients With Multiple Myeloma

  NCT03582033

  Condition:   Multiple Myeloma
  Intervention:   Drug: SEA-BCMA
  Sponsor:   Seattle Genetics, Inc.
  Recruiting
• Pentoxifylline and Tocopherol (PENTO) in the Treatment of Medication-related Osteonecrosis of the Jaw (MRONJ)

  NCT03040778

  Conditions:   Medication-related Osteonecrosis of the Jaw;   Bisphosphonate-related Osteonecrosis of the Jaw;   Avascular Necrosis
  Interventions:   Drug: Pentoxifylline;   Drug: Placebo;   Drug: Tocopherol
  Sponsors:   University of Washington;   University of Alabama at Birmingham;   New York Center for Orthognathic and Maxillofacial Surgery;   Oregon Health and Science University;   University of Michigan
  Recruiting
• Pelvital Stress Urinary Incontinence Training Device: P-SUIT

  NCT02954042

  Condition:   Incontinence
  Interventions:   Device: Pelvital probe;   Device: Placebo Probe
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• Pembrolizumab in Refractory Metastatic Anal Cancer

  NCT02919969

  Condition:   Anal Cancer
  Intervention:   Drug: Pembrolizumab
  Sponsors:   Dana-Farber Cancer Institute;   Merck Sharp & Dohme Corp.
  Recruiting
• Treosulfan, Fludarabine Phosphate, and Total-Body Irradiation in Treating Patients With Hematological Cancer Who Are Undergoing Umbilical Cord Blood Transplant

  NCT00796068

  Conditions:   Acute Biphenotypic Leukemia;   Acute Lymphoblastic Leukemia in Remission;   Acute Myeloid Leukemia in Remission;   Blasts Under 5 Percent of Bone Marrow Nucleated Cells;   Chronic Myelogenous Leukemia, BCR-ABL1 Positive;   Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive;   Myelodysplastic Syndrome
  Interventions:   Drug: Cyclosporine;   Drug: Fludarabine Phosphate;   Other: Laboratory Biomarker Analysis;   Drug: Mycophenolate Mofetil;   Radiation: Total-Body Irradiation;   Drug: Treosulfan;   Procedure: Umbilical Cord Blood Transplantation
  Sponsors:   Fred Hutchinson Cancer Research Center;   National Cancer Institute (NCI)
  Recruiting
• Cholinesterase Inhibitor Discontinuation

  NCT02248636

  Condition:   Dementia
  Interventions:   Drug: Cholinesterase inhibitor;   Drug: Sham discontinuation
  Sponsor:   VA Office of Research and Development
  Recruiting
• Ibrutinib and Obinutuzumab With or Without Venetoclax in Treating Older Patients With Untreated Chronic Lymphocytic Leukemia

  NCT03737981

  Condition:   Chronic Lymphocytic Leukemia
  Interventions:   Drug: Ibrutinib;   Biological: Obinutuzumab;   Other: Observation;   Drug: Venetoclax
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Palbociclib and Letrozole or Fulvestrant in Treating Patients With Estrogen Receptor Positive, HER2 Negative Metastatic Breast Cancer

  NCT03633331

  Conditions:   Estrogen Receptor-positive Breast Cancer;   HER2/Neu Negative;   Stage IV Breast Cancer AJCC v6 and v7
  Interventions:   Drug: Palbociclib;   Drug: Letrozole;   Drug: Fulvestrant;   Other: Questionnaire Administration;   Other: Quality-of-Life Assessment
  Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI)
  Recruiting
• A Study of Bendamustine and Rituximab Alone Versus in Combination With Acalabrutinib in Subjects With Previously Untreated Mantle Cell Lymphoma

  NCT02972840

  Condition:   Lymphoma, Mantle Cell
  Interventions:   Drug: Acalabrutinib in combination with bendamustine and rituximab;   Drug: Placebo in combination with bendamustine and rituximab
  Sponsor:   Acerta Pharma BV
  Recruiting
• Diffusion MRI-1 Imaging Database

  NCT03775694

  Conditions:   Epilepsy;   Tumor;   Healthy;   Other
  Intervention:   Device: dMRI Scan
  Sponsor:   Medtronic Surgical Technologies
  Recruiting
• EXtremely Early-onset Type 1 Diabetes EXtremely Early-onset Type 1 Diabetes (A Musketeers' Memorandum Study)

  NCT03369821

  Condition:   Type1 Diabetes Mellitus
  Interventions:   Diagnostic Test: Beta Cell Loss and Immune Function;   Other: Immune Function with RNAseq
  Sponsors:   University of Exeter;   Royal Devon and Exeter NHS Foundation Trust;   King's College London;   City of Hope National Medical Center;   Benaroya Research Institute
  Recruiting
• Efficacy and Safety of Pegzilarginase in Patients With Arginase 1 Deficiency

  NCT03921541

  Conditions:   Arginase I Deficiency;   Hyperargininemia
  Interventions:   Drug: Pegzilarginase;   Drug: Placebo
  Sponsor:   Aeglea Biotherapeutics
  Recruiting
• Dried Blood Spot Testing of CMV Detection in HCT Recipients

  NCT03910478

  Condition:   Cytomegalovirus Infection
  Interventions:   Device: DBS Self-Collection Kit;   Other: Standard Control Strategy
  Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
  Recruiting
• Second-line Study of PEGPH20 and Pembro for HA High Metastatic PDAC

  NCT03634332

  Conditions:   Pancreatic Ductal Adenocarcinoma;   Pancreatic Cancer;   Pancreatic Neoplasms
  Interventions:   Drug: PEGPH20;   Biological: Pembrolizumab
  Sponsors:   Pancreatic Cancer Research Team;   Merck Sharp & Dohme Corp.;   Halozyme Therapeutics;   University of Washington
  Recruiting
• Evaluating the Efficacy and Safety of Transitioning Patients From Natalizumab to Ocrelizumab

  NCT03157830

  Condition:   Relapsing Remitting Multiple Sclerosis
  Intervention:  
  Sponsors:   Providence Health & Services;   Genentech, Inc.
  Recruiting
• A Study of AG-636 in the Treatment of Subjects With Advanced Lymphoma

  NCT03834584

  Condition:   Lymphoma
  Intervention:   Drug: AG-636
  Sponsor:   Agios Pharmaceuticals, Inc.
  Recruiting
• Spinraza in Adult Spinal Muscular Atrophy

  NCT03709784

  Conditions:   Spinal Muscular Atrophy;   Spinal Muscular Atrophy Type II;   Spinal Muscular Atrophy Type 3
  Intervention:   Other: Observational study to examine safety, tolerability, and effectiveness of SPINRAZA® prescribed as part of standard of care
  Sponsor:   Washington University School of Medicine
  Recruiting
• A Phase 1 Study of Voruciclib in Subjects With B-Cell Malignancies or AML

  NCT03547115

  Conditions:   Follicular Lymphoma (FL);   Mantle Cell Lymphoma (MCL);   Marginal Zone Lymphoma (MZL);   Small Lymphocytic Lymphoma (SLL);   Chronic Lymphocytic Leukemia (CLL);   Diffuse Large B-cell Lymphoma (DLBCL);   Acute Myeloid Leukemia (AML)
  Intervention:   Drug: Voruciclib
  Sponsor:   MEI Pharma, Inc.
  Recruiting
• PhII Trial Panitumumab, Nivolumab, Ipilimumab in Kras/Nras/BRAF Wild-type MSS Refractory mCRC

  NCT03442569

  Condition:   Colon Cancer
  Interventions:   Drug: Panitumumab;   Drug: Nivolumab;   Drug: Ipilimumab
  Sponsors:   UNC Lineberger Comprehensive Cancer Center;   Amgen;   Bristol-Myers Squibb
  Recruiting
• A Study of Daratumumab in Patients With Relapsed or Refractory Waldenström Macroglobulinemia

  NCT03187262

  Condition:   Waldenström Macroglobulinemia
  Intervention:   Drug: Daratumumab
  Sponsors:   Dana-Farber Cancer Institute;   Janssen, LP
  Recruiting
• SEL24/MEN1703 in Patients With Acute Myeloid Leukemia

  NCT03008187

  Condition:   Acute Myeloid Leukemia
  Intervention:   Drug: SEL24/MEN1703
  Sponsors:   Menarini Group;   Medpace, Inc.;   Theradex
  Recruiting
• Randomized Trial of Early Hemodynamic Management of Patients Following Acute Spinal Cord Injury

  NCT02878850

  Condition:   Spinal Cord Injury
  Intervention:   Other: Augmented Blood Pressure
  Sponsors:   Oregon Health and Science University;   United States Department of Defense
  Recruiting
• Use of an Experimental Drug, CC-115, With Enzalutamide in Men With Castration-Resistant Prostate Cancer

  NCT02833883

  Conditions:   Prostate Cancer;   Castration Resistant Prostate Cancer
  Interventions:   Drug: Enzalutamide;   Drug: CC-115
  Sponsors:   Memorial Sloan Kettering Cancer Center;   Celgene Corporation
  Recruiting
• Vaccine Therapy in Reducing the Frequency of Cytomegalovirus Events in Patients With Hematologic Malignancies Undergoing Donor Stem Cell Transplant

  NCT02396134

  Conditions:   Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive;   Adult Acute Lymphoblastic Leukemia in Remission;   Adult Acute Myeloid Leukemia in Remission;   Adult Hodgkin Lymphoma;   Adult Non-Hodgkin Lymphoma;   Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive;   Cytomegaloviral Infection;   Hematopoietic and Lymphoid Cell Neoplasm;   HLA-A*0201 Positive Cells Present;   Myelodysplastic Syndrome;   Adult Lymphoblastic Lymphoma;   Chronic Lymphocytic Leukemia;   Myelofibrosis;   Myeloproliferative Neoplasm
  Interventions:   Biological: CMVpp65-A*0201 peptide vaccine;   Other: Placebo;   Other: Laboratory Biomarker Analysis
  Sponsors:   City of Hope Medical Center;   National Cancer Institute (NCI)
  Recruiting
• Ibrutinib and Obinutuzumab With or Without Venetoclax in Treating Patients With Chronic Lymphocytic Leukemia

  NCT03701282

  Conditions:   CCND1/IGHG1 Fusion Negative;   Chronic Lymphocytic Leukemia;   Small Lymphocytic Lymphoma;   t(11;14) Negative
  Interventions:   Drug: Ibrutinib;   Biological: Obinutuzumab;   Other: Quality-of-Life Assessment;   Drug: Venetoclax
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Carboplatin and Paclitaxel With or Without Ramucirumab in Treating Patients With Locally Advanced, Recurrent, or Metastatic Thymic Cancer That Cannot Be Removed by Surgery

  NCT03694002

  Conditions:   Locally Advanced Thymic Carcinoma;   Metastatic Thymic Carcinoma;   Recurrent Thymic Carcinoma;   Unresectable Thymic Carcinoma
  Interventions:   Drug: Carboplatin;   Drug: Paclitaxel;   Biological: Ramucirumab
  Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• Ruxolitinib Phosphate and Dasatinib or Nilotinib in Treating Patients With Chronic Myeloid Leukemia

  NCT03654768

  Condition:   Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive
  Interventions:   Drug: Dasatinib;   Other: Laboratory Biomarker Analysis;   Drug: Nilotinib;   Drug: Ruxolitinib Phosphate
  Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• S1501 Carvedilol in Preventing Cardiac Toxicity in Patients With Metastatic HER-2-Positive Breast Cancer

  NCT03418961

  Conditions:   Cardiotoxicity;   HER2/Neu Positive;   Metastatic Malignant Neoplasm in the Brain;   Recurrent Breast Carcinoma;   Stage IV Breast Cancer AJCC v6 and v7
  Interventions:   Drug: Carvedilol;   Other: Laboratory Biomarker Analysis;   Other: Patient Observation
  Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• Pembrolizumab in Treating Patients With Locally Advanced Bladder Cancer

  NCT03244384

  Conditions:   Stage II Bladder Urothelial Carcinoma AJCC v6 and v7;   Stage III Bladder Urothelial Carcinoma AJCC v6 and v7
  Interventions:   Other: Clinical Observation;   Other: Laboratory Biomarker Analysis;   Biological: Pembrolizumab;   Other: Pharmacological Study;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Nivolumab After Combined Modality Therapy in Treating Patients With High Risk Stage II-IIIB Anal Cancer

  NCT03233711

  Conditions:   Anal Basaloid Carcinoma;   Anal Canal Cloacogenic Carcinoma;   Anal Margin Squamous Cell Carcinoma;   Stage IIB Anal Cancer AJCC v8;   Stage IIIA Anal Cancer AJCC v8;   Stage IIIB Anal Cancer AJCC v8;   Stage IIIC Anal Cancer AJCC v8
  Interventions:   Biological: Nivolumab;   Other: Patient Observation
  Sponsors:   National Cancer Institute (NCI);   Canadian Cancer Trials Group
  Recruiting
• Aspirin in Preventing Recurrence of Cancer in Patients With HER2 Negative Stage II-III Breast Cancer After Chemotherapy, Surgery, and/or Radiation Therapy

  NCT02927249

  Condition:   Node Positive HER2 Negative Breast Cancer
  Interventions:   Other: Placebo;   Drug: Aspirin
  Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI);   United States Department of Defense;   Bayer;   Canadian Cancer Trials Group
  Recruiting
• Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair

  NCT02912559

  Conditions:   Colon Adenocarcinoma;   DNA Repair Disorder;   Lynch Syndrome;   Stage III Colon Cancer AJCC v7;   Stage IIIA Colon Cancer AJCC v7;   Stage IIIB Colon Cancer AJCC v7;   Stage IIIC Colon Cancer AJCC v7
  Interventions:   Drug: Atezolizumab;   Drug: Fluorouracil;   Other: Laboratory Biomarker Analysis;   Drug: Leucovorin Calcium;   Drug: Oxaliplatin;   Other: Quality-of-Life Assessment
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Nivolumab and Ipilimumab in Treating Patients With Rare Tumors

  NCT02834013

  Conditions:   Acinar Cell Carcinoma;   Adenoid Cystic Carcinoma;   Adrenal Cortex Carcinoma;   Adrenal Gland Pheochromocytoma;   Anal Canal Neuroendocrine Carcinoma;   Anal Canal Undifferentiated Carcinoma;   Angiosarcoma;   Apocrine Neoplasm;   Appendix Mucinous Adenocarcinoma;   Bartholin Gland Transitional Cell Carcinoma;   Basal Cell Carcinoma;   Bladder Adenocarcinoma;   Cervical Adenocarcinoma;   Cervical Clear Cell Adenocarcinoma;   Cholangiocarcinoma;   Chordoma;   Colorectal Squamous Cell Carcinoma;   Desmoid-Type Fibromatosis;   Endometrial Transitional Cell Carcinoma;   Endometrioid Adenocarcinoma;   Esophageal Neuroendocrine Carcinoma;   Esophageal Undifferentiated Carcinoma;   Extrahepatic Bile Duct Carcinoma;   Extramammary Paget Disease;   Fallopian Tube Adenocarcinoma;   Fallopian Tube Transitional Cell Carcinoma;   Fibromyxoid Tumor;   Gallbladder Carcinoma;   Gastric Neuroendocrine Carcinoma;   Gastric Squamous Cell Carcinoma;   Gastric Undifferentiated Carcinoma;   Gastrointestinal Stromal Tumor;   Gestational Trophoblastic Tumor;   Giant Cell Carcinoma;   Intestinal Neuroendocrine Carcinoma;   Intrahepatic Cholangiocarcinoma;   Lung Carcinoid Tumor;   Lung Sarcomatoid Carcinoma;   Major Salivary Gland Carcinoma;   Malignant Odontogenic Neoplasm;   Malignant Peripheral Nerve Sheath Tumor;   Malignant Testicular Sex Cord-Stromal Tumor;   Metaplastic Breast Carcinoma;   Metastatic Malignant Neoplasm of Unknown Primary;   Minimally Invasive Lung Adenocarcinoma;   Mixed Mesodermal (Mullerian) Tumor;   Mucinous Adenocarcinoma;   Mucinous Cystadenocarcinoma;   Nasal Cavity Adenocarcinoma;   Nasal Cavity Carcinoma;   Nasopharyngeal Carcinoma;   Nasopharyngeal Papillary Adenocarcinoma;   Nasopharyngeal Undifferentiated Carcinoma;   Oral Cavity Carcinoma;   Oropharyngeal Undifferentiated Carcinoma;   Ovarian Adenocarcinoma;   Ovarian Clear Cell Adenocarcinoma;   Ovarian Germ Cell Tumor;   Ovarian Mucinous Adenocarcinoma;   Ovarian Squamous Cell Carcinoma;   Ovarian Transitional Cell Carcinoma;   Pancreatic Acinar Cell Carcinoma;   Pancreatic Neuroendocrine Carcinoma;   Paraganglioma;   Paranasal Sinus Adenocarcinoma;   Paranasal Sinus Carcinoma;   Parathyroid Gland Carcinoma;   PEComa;   Peritoneal Mesothelioma;   Pituitary Gland Carcinoma;   Placental Choriocarcinoma;   Primary Peritoneal High Grade Serous Adenocarcinoma;   Pseudomyxoma Peritonei;   Rare Disorder;   Scrotal Squamous Cell Carcinoma;   Seminal Vesicle Adenocarcinoma;   Seminoma;   Serous Cystadenocarcinoma;   Small Intestinal Adenocarcinoma;   Small Intestinal Squamous Cell Carcinoma;   Solid Neoplasm;   Spindle Cell Neoplasm;   Squamous Cell Carcinoma of the Penis;   Teratoma With Somatic-Type Malignancy;   Testicular Non-Seminomatous Germ Cell Tumor;   Thyroid Gland Carcinoma;   Tracheal Carcinoma;   Transitional Cell Carcinoma;   Ureter Adenocarcinoma;   Ureter Squamous Cell Carcinoma;   Urethral Adenocarcinoma;   Urethral Squamous Cell Carcinoma;   Vaginal Adenocarcinoma;   Vaginal Squamous Cell Carcinoma, Not Otherwise Specified;   Vulvar Carcinoma
  Interventions:   Procedure: Biospecimen Collection;   Biological: Ipilimumab;   Biological: Nivolumab
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Breast Cancer WEight Loss Study (BWEL Study)

  NCT02750826

  Condition:   Breast Carcinoma
  Interventions:   Other: Health Education Program;   Other: Weight Loss Intervention
  Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI);   Division of Cancer Control;   NIH Biomarker, Imaging and Quality of Life Studies Funding Program (BIQSFP);   Canadian Cancer Trials Group
  Recruiting
• Ramucirumab and Pembrolizumab Versus Standard of Care in Treating Patients With Stage IV or Recurrent Non-small Cell Lung Cancer (A Lung-MAP Non-Match Treatment Trial)

  NCT03971474

  Conditions:   Recurrent Lung Non-Small Cell Carcinoma;   Stage IV Lung Cancer AJCC v8;   Stage IVA Lung Cancer AJCC v8;   Stage IVB Lung Cancer AJCC v8
  Interventions:   Drug: Docetaxel;   Drug: Gemcitabine;   Drug: Gemcitabine Hydrochloride;   Biological: Pembrolizumab;   Drug: Pemetrexed;   Drug: Pemetrexed Disodium;   Biological: Ramucirumab
  Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• Ipilimumab With or Without Nivolumab in Treating Patients With Melanoma That Is Stage IV or Stage III and Cannot Be Removed by Surgery

  NCT03033576

  Conditions:   Advanced Melanoma;   Melanoma of Unknown Primary;   Mucosal Melanoma;   Refractory Melanoma;   Stage III Cutaneous Melanoma AJCC v7;   Stage IIIA Cutaneous Melanoma AJCC v7;   Stage IIIB Cutaneous Melanoma AJCC v7;   Stage IIIC Cutaneous Melanoma AJCC v7;   Stage IV Cutaneous Melanoma AJCC v6 and v7;   Unresectable Cutaneous Melanoma;   Unresectable Melanoma
  Interventions:   Biological: Ipilimumab;   Biological: Nivolumab
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Firstline Pembrolizumab Alone or in Combination With Pemetrexed and Carboplatin in Induction/Maintenance or Postprogression in Treating Patients With Stage IV Non-squamous Non-small Cell Lung Cancer

  NCT03793179

  Conditions:   Lung Non-Squamous Non-Small Cell Carcinoma;   PD-L1 Positive;   Stage IIIB Lung Cancer AJCC v8;   Stage IIIC Lung Cancer AJCC v8;   Stage IVA Lung Cancer AJCC v8
  Interventions:   Drug: Carboplatin;   Biological: Pembrolizumab;   Drug: Pemetrexed
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Gemcitabine Hydrochloride and Cisplatin With or Without Nab-Paclitaxel in Treating Patients With Newly Diagnosed Advanced Biliary Tract Cancers

  NCT03768414

  Conditions:   Stage III Distal Bile Duct Cancer AJCC v8;   Stage III Gallbladder Cancer AJCC v8;   Stage III Intrahepatic Cholangiocarcinoma AJCC v8;   Stage IIIA Distal Bile Duct Cancer AJCC v8;   Stage IIIA Gallbladder Cancer AJCC v8;   Stage IIIA Intrahepatic Cholangiocarcinoma AJCC v8;   Stage IIIB Distal Bile Duct Cancer AJCC v8;   Stage IIIB Gallbladder Cancer AJCC v8;   Stage IIIB Intrahepatic Cholangiocarcinoma AJCC v8;   Stage IV Distal Bile Duct Cancer AJCC v8;   Stage IV Gallbladder Cancer AJCC v8;   Stage IV Intrahepatic Cholangiocarcinoma AJCC v8;   Stage IVA Gallbladder Cancer AJCC v8;   Stage IVB Gallbladder Cancer AJCC v8;   Unresectable Extrahepatic Bile Duct Carcinoma;   Unresectable Gallbladder Carcinoma;   Unresectable Intrahepatic Cholangiocarcinoma
  Interventions:   Drug: Cisplatin;   Drug: Gemcitabine Hydrochloride;   Drug: Nab-paclitaxel
  Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• Serum Tumor Marker Directed Disease Monitoring in Patients With Hormone Receptor Positive Her2 Negative Metastatic Breast Cancer

  NCT03723928

  Conditions:   Anatomic Stage IV Breast Cancer AJCC v8;   Estrogen Receptor Positive;   HER2/Neu Negative;   Progesterone Receptor Positive;   Prognostic Stage IV Breast Cancer AJCC v8;   Elevated CA15-3 or CEA or CA27-29
  Interventions:   Other: Usual care disease monitoring;   Other: Serum Tumor Marker directed disease monitoring;   Other: Quality-of-Life Assessment;   Other: Anxiety Questionnaire Administration
  Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

  NCT02465060

  Conditions:   Advanced Malignant Solid Neoplasm;   Bladder Carcinoma;   Breast Carcinoma;   Cervical Carcinoma;   Colon Carcinoma;   Colorectal Carcinoma;   Endometrial Carcinoma;   Esophageal Carcinoma;   Gastric Carcinoma;   Glioma;   Head and Neck Carcinoma;   Kidney Carcinoma;   Liver and Intrahepatic Bile Duct Carcinoma;   Lung Carcinoma;   Lymphoma;   Malignant Uterine Neoplasm;   Melanoma;   Ovarian Carcinoma;   Pancreatic Carcinoma;   Plasma Cell Myeloma;   Prostate Carcinoma;   Rectal Carcinoma;   Recurrent Bladder Carcinoma;   Recurrent Breast Carcinoma;   Recurrent Cervical Carcinoma;   Recurrent Colon Carcinoma;   Recurrent Colorectal Carcinoma;   Recurrent Esophageal Carcinoma;   Recurrent Gastric Carcinoma;   Recurrent Glioma;   Recurrent Head and Neck Carcinoma;   Recurrent Liver Carcinoma;   Recurrent Lung Carcinoma;   Recurrent Lymphoma;   Recurrent Malignant Solid Neoplasm;   Recurrent Melanoma;   Recurrent Ovarian Carcinoma;   Recurrent Pancreatic Carcinoma;   Recurrent Plasma Cell Myeloma;   Recurrent Prostate Carcinoma;   Recurrent Rectal Carcinoma;   Recurrent Skin Carcinoma;   Recurrent Thyroid Gland Carcinoma;   Recurrent Uterine Corpus Carcinoma;   Refractory Lymphoma;   Refractory Malignant Solid Neoplasm;   Refractory Plasma Cell Myeloma;   Skin Carcinoma;   Thyroid Gland Carcinoma;   Uterine Corpus Cancer
  Interventions:   Drug: Adavosertib;   Drug: Afatinib;   Drug: Afatinib Dimaleate;   Drug: Binimetinib;   Drug: Capivasertib;   Drug: Copanlisib;   Drug: Copanlisib Hydrochloride;   Drug: Crizotinib;   Other: Cytology Specimen Collection Procedure;   Drug: Dabrafenib;   Drug: Dabrafenib Mesylate;   Drug: Dasatinib;   Drug: Defactinib;   Drug: Defactinib Hydrochloride;   Drug: Erdafitinib;   Drug: FGFR Inhibitor AZD4547;   Drug: Ipatasertib;   Other: Laboratory Biomarker Analysis;   Drug: Larotrectinib;   Drug: Larotrectinib Sulfate;   Biological: Nivolumab;   Drug: Osimertinib;   Drug: Palbociclib;   Biological: Pertuzumab;   Drug: PI3K-beta Inhibitor GSK2636771;   Drug: Sapanisertib;   Drug: Sunitinib Malate;   Drug: Taselisib;   Drug: Trametinib;   Biological: Trastuzumab;   Biological: Trastuzumab Emtansine;   Drug: Ulixertinib;   Drug: Vismodegib
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Pembrolizumab in Treating Patients With Stage III-IV High-Risk Melanoma Before and After Surgery

  NCT03698019

  Conditions:   Acral Lentiginous Melanoma;   Clinical Stage III Cutaneous Melanoma AJCC v8;   Clinical Stage IV Cutaneous Melanoma AJCC v8;   Mucosal Melanoma;   Pathologic Stage III Cutaneous Melanoma AJCC v8;   Pathologic Stage IIIA Cutaneous Melanoma AJCC v8;   Pathologic Stage IIIB Cutaneous Melanoma AJCC v8;   Pathologic Stage IIIC Cutaneous Melanoma AJCC v8;   Pathologic Stage IIID Cutaneous Melanoma AJCC v8;   Pathologic Stage IV Cutaneous Melanoma AJCC v8
  Interventions:   Biological: Pembrolizumab;   Procedure: Therapeutic Conventional Surgery
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Cediranib Maleate and Olaparib or Standard Chemotherapy in Treating Patients With Recurrent Platinum-Resistant or -Refractory Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

  NCT02502266

  Conditions:   Deleterious BRCA1 Gene Mutation;   Deleterious BRCA2 Gene Mutation;   Fallopian Tube Clear Cell Adenocarcinoma;   Fallopian Tube Endometrioid Adenocarcinoma;   Fallopian Tube Serous Adenocarcinoma;   Fallopian Tube Transitional Cell Carcinoma;   Fallopian Tube Undifferentiated Carcinoma;   Ovarian Clear Cell Adenocarcinoma;   Ovarian Endometrioid Adenocarcinoma;   Ovarian Seromucinous Carcinoma;   Ovarian Serous Adenocarcinoma;   Ovarian Transitional Cell Carcinoma;   Ovarian Undifferentiated Carcinoma;   Primary Peritoneal Serous Adenocarcinoma;   Recurrent Fallopian Tube Carcinoma;   Recurrent Ovarian Carcinoma;   Recurrent Primary Peritoneal Carcinoma
  Interventions:   Drug: Cediranib;   Drug: Cediranib Maleate;   Other: Laboratory Biomarker Analysis;   Drug: Olaparib;   Drug: Paclitaxel;   Drug: Pegylated Liposomal Doxorubicin Hydrochloride;   Other: Questionnaire Administration;   Drug: Topotecan;   Drug: Topotecan Hydrochloride
  Sponsors:   National Cancer Institute (NCI);   NRG Oncology
  Recruiting
• Doxorubicin Hydrochloride and Cyclophosphamide Followed by Paclitaxel With or Without Carboplatin in Treating Patients With Triple-Negative Breast Cancer

  NCT02488967

  Conditions:   Breast Adenocarcinoma;   Estrogen Receptor Negative;   HER2/Neu Negative;   Progesterone Receptor Negative;   Stage IB Breast Cancer;   Stage IIA Breast Cancer;   Stage IIB Breast Cancer;   Stage IIIA Breast Cancer;   Stage IIIC Breast Cancer;   Triple-Negative Breast Carcinoma
  Interventions:   Drug: Carboplatin;   Drug: Cyclophosphamide;   Drug: Doxorubicin Hydrochloride;   Other: Laboratory Biomarker Analysis;   Drug: Paclitaxel
  Sponsors:   NRG Oncology;   National Cancer Institute (NCI)
  Recruiting
• S1702 Isatuximab in Treating Patients With Relapsed or Refractory Primary Amyloidosis

  NCT03499808

  Conditions:   Amorphous, Eosinophilic, and Acellular Deposit;   Constipation;   Diarrhea;   Early Satiety;   Gastrointestinal Hemorrhage;   Hepatomegaly;   Lymphadenopathy;   Macroglossia;   Nausea;   Primary Systemic Amyloidosis;   Purpura;   Recurrent Primary Amyloidosis;   Refractory Primary Amyloidosis
  Interventions:   Biological: Isatuximab;   Other: Laboratory Biomarker Analysis
  Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• Hypofractionated Radiation Therapy After Mastectomy in Preventing Recurrence in Patients With Stage IIa-IIIa Breast Cancer

  NCT03414970

  Conditions:   Ductal Breast Carcinoma;   Invasive Breast Carcinoma;   Lobular Breast Carcinoma;   Medullary Breast Carcinoma;   Stage II Breast Cancer;   Stage IIA Breast Cancer;   Stage IIB Breast Cancer;   Stage IIIA Breast Cancer;   Tubular Breast Carcinoma
  Interventions:   Radiation: Radiation Therapy;   Other: Questionnaire Administration;   Other: Quality-of-Life Assessment;   Other: Laboratory Biomarker Analysis;   Radiation: Hypofractionated Radiation Therapy
  Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI);   Canadian Cancer Trials Group
  Recruiting
• Crizotinib in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been Removed by Surgery and ALK Fusion Mutations (An ALCHEMIST Treatment Trial)

  NCT02201992

  Conditions:   ALK Gene Rearrangement;   ALK Gene Translocation;   ALK Positive;   Stage IB Non-Small Cell Lung Carcinoma AJCC v7;   Stage II Non-Small Cell Lung Cancer AJCC v7;   Stage IIA Non-Small Cell Lung Carcinoma AJCC v7;   Stage IIB Non-Small Cell Lung Carcinoma AJCC v7;   Stage IIIA Non-Small Cell Lung Cancer AJCC v7
  Interventions:   Other: Clinical Observation;   Drug: Crizotinib;   Other: Laboratory Biomarker Analysis
  Sponsors:   ECOG-ACRIN Cancer Research Group;   National Cancer Institute (NCI)
  Recruiting
• Genetic Testing in Screening Patients With Stage IB-IIIA Non-Small Cell Lung Cancer That Has Been or Will Be Removed by Surgery (The ALCHEMIST Screening Trial)

  NCT02194738

  Conditions:   Lung Adenocarcinoma;   Lung Large Cell Carcinoma;   Stage IB Lung Non-Small Cell Carcinoma AJCC v7;   Stage IB Lung Squamous Cell Carcinoma AJCC v7;   Stage II Lung Non-Small Cell Cancer AJCC v7;   Stage II Lung Squamous Cell Carcinoma AJCC v7;   Stage IIA Lung Non-Small Cell Carcinoma AJCC v7;   Stage IIA Lung Squamous Cell Carcinoma AJCC v7;   Stage IIB Lung Non-Small Cell Carcinoma AJCC v7;   Stage IIB Lung Squamous Cell Carcinoma AJCC v7;   Stage IIIA Lung Non-Small Cell Cancer AJCC v7;   Stage IIIA Lung Squamous Cell Carcinoma AJCC v7
  Interventions:   Other: Clinical Observation;   Drug: Crizotinib;   Other: Cytology Specimen Collection Procedure;   Drug: Erlotinib Hydrochloride;   Biological: Nivolumab;   Other: Placebo
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Erlotinib Hydrochloride in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been Completely Removed by Surgery (An ALCHEMIST Treatment Trial)

  NCT02193282

  Conditions:   ALK Gene Rearrangement;   EGFR Exon 19 Deletion Mutation;   EGFR NP_005219.2:p.L858R;   Stage IB Lung Non-Small Cell Carcinoma AJCC v7;   Stage II Lung Non-Small Cell Cancer AJCC v7;   Stage IIA Lung Non-Small Cell Carcinoma AJCC v7;   Stage IIB Lung Non-Small Cell Carcinoma AJCC v7;   Stage IIIA Lung Non-Small Cell Cancer AJCC v7
  Interventions:   Other: Clinical Observation;   Drug: Erlotinib Hydrochloride;   Other: Laboratory Biomarker Analysis;   Other: Placebo
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Dabrafenib and Trametinib Followed by Ipilimumab and Nivolumab or Ipilimumab and Nivolumab Followed by Dabrafenib and Trametinib in Treating Patients With Stage III-IV BRAFV600 Melanoma

  NCT02224781

  Conditions:   BRAF NP_004324.2:p.V600X;   Metastatic Melanoma;   Progressive Disease;   Recurrent Melanoma;   Stage III Cutaneous Melanoma AJCC v7;   Stage IIIA Cutaneous Melanoma AJCC v7;   Stage IIIB Cutaneous Melanoma AJCC v7;   Stage IIIC Cutaneous Melanoma AJCC v7;   Stage IV Cutaneous Melanoma AJCC v6 and v7;   Unresectable Cutaneous Melanoma
  Interventions:   Drug: Dabrafenib;   Drug: Dabrafenib Mesylate;   Biological: Ipilimumab;   Biological: Nivolumab;   Other: Quality-of-Life Assessment;   Drug: Trametinib;   Drug: Trametinib Dimethyl Sulfoxide
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Low-Dose Ibuprofen in Improving Cognitive Impairment in Patients With Non-metastatic Colorectal Cancer Receiving Chemotherapy

  NCT03186638

  Conditions:   Caregiver;   Cognitive Impairment;   Stage 0 Colorectal Cancer AJCC v6 and v7;   Stage I Colorectal Cancer AJCC v6 and v7;   Stage II Colorectal Cancer AJCC v7;   Stage IIA Colorectal Cancer AJCC v7;   Stage IIB Colorectal Cancer AJCC v7;   Stage IIC Colorectal Cancer AJCC v7;   Stage III Colorectal Cancer AJCC v7;   Stage IIIA Colorectal Cancer AJCC v7;   Stage IIIB Colorectal Cancer AJCC v7;   Stage IIIC Colorectal Cancer AJCC v7
  Interventions:   Drug: Ibuprofen;   Other: Placebo;   Other: Questionnaire Administration
  Sponsors:   Gary Morrow;   National Cancer Institute (NCI)
  Recruiting
• Naloxegol in Treating Patients With Stage IIIB-IV Non-small Cell Lung Cancer

  NCT03087708

  Conditions:   Stage IIIB Non-Small Cell Lung Cancer;   Stage IV Non-small Cell Lung Cancer
  Interventions:   Drug: Naloxegol;   Other: Placebo;   Other: Laboratory Biomarker Analysis;   Other: Quality-of-Life Assessment
  Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI)
  Recruiting
• Comparison of Axillary Lymph Node Dissection With Axillary Radiation for Patients With Node-Positive Breast Cancer Treated With Chemotherapy

  NCT01901094

  Conditions:   Stage II Breast Cancer;   Stage IIIA Breast Cancer
  Interventions:   Procedure: Axillary Lymph Node Dissection (ALND);   Radiation: Nodal Radiation Therapy;   Radiation: Axillary Radiation Therapy
  Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI);   Canadian Cancer Trials Group
  Recruiting
• Pembrolizumab in Treating Patients With Triple-Negative Breast Cancer

  NCT02954874

  Conditions:   Estrogen Receptor Negative;   HER2/Neu Negative;   Invasive Breast Carcinoma;   Progesterone Receptor Negative;   Stage 0 Breast Cancer AJCC v6 and v7;   Stage I Breast Cancer AJCC v7;   Stage IA Breast Cancer AJCC v7;   Stage IB Breast Cancer AJCC v7;   Stage II Breast Cancer AJCC v6 and v7;   Stage IIA Breast Cancer AJCC v6 and v7;   Stage IIB Breast Cancer AJCC v6 and v7;   Stage III Breast Cancer AJCC v7;   Stage IIIA Breast Cancer AJCC v7;   Stage IIIB Breast Cancer AJCC v7;   Stage IIIC Breast Cancer AJCC v7;   Triple-Negative Breast Carcinoma
  Interventions:   Other: Laboratory Biomarker Analysis;   Other: Patient Observation;   Biological: Pembrolizumab;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration;   Radiation: Radiation Therapy
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Veliparib, Pembrolizumab, and Combination Chemotherapy in Treating Patient With Locally Advanced Rectal Cancer

  NCT02921256

  Conditions:   Rectal Adenocarcinoma;   Stage II Rectal Cancer AJCC v7;   Stage III Rectal Cancer AJCC v7
  Interventions:   Drug: Capecitabine;   Drug: Fluorouracil;   Radiation: Intensity-Modulated Radiation Therapy;   Drug: Leucovorin Calcium;   Drug: Oxaliplatin;   Biological: Pembrolizumab;   Drug: Veliparib
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Combination Chemotherapy With or Without Blinatumomab in Treating Patients With Newly Diagnosed BCR-ABL-Negative B Lineage Acute Lymphoblastic Leukemia

  NCT02003222

  Conditions:   Acute Lymphoblastic Leukemia;   B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative;   BCR/ABL1 Fusion Protein Negative;   Untreated Adult Acute Lymphoblastic Leukemia
  Interventions:   Procedure: Allogeneic Hematopoietic Stem Cell Transplantation;   Biological: Blinatumomab;   Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: Daunorubicin Hydrochloride;   Drug: Dexamethasone;   Drug: Etoposide;   Other: Laboratory Biomarker Analysis;   Drug: Mercaptopurine;   Drug: Methotrexate;   Drug: Pegaspargase;   Drug: Prednisone;   Biological: Rituximab;   Drug: Vincristine Sulfate
  Sponsors:   National Cancer Institute (NCI);   Canadian Cancer Trials Group
  Recruiting
• S1505: Combination Chemotherapy or Gemcitabine Hydrochloride and Paclitaxel Albumin-Stabilized Nanoparticle Formulation Before Surgery in Treating Patients With Pancreatic Cancer That Can Be Removed by Surgery

  NCT02562716

  Conditions:   Pancreatic Adenocarcinoma;   Resectable Pancreatic Carcinoma
  Interventions:   Drug: Fluorouracil;   Drug: Gemcitabine Hydrochloride;   Drug: Irinotecan Hydrochloride;   Drug: Oxaliplatin;   Drug: Paclitaxel Albumin-Stabilized Nanoparticle Formulation;   Procedure: Pancreatectomy
  Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• S0820, Adenoma and Second Primary Prevention Trial

  NCT01349881

  Condition:   Colorectal Neoplasms
  Interventions:   Drug: Eflornithine placebo & sulindac placebo;   Drug: eflornithine & sulindac placebo;   Drug: Eflornithine placebo & sulindac;   Drug: Eflornithine plus sulindac
  Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI);   Cancer Prevention Pharmaceuticals, Inc.
  Recruiting