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• Observation vs Early Removal of LAMS in EUS Guided Cholecystoenterostomy

  NCT04167072

  Conditions:   Cholecystitis, Acute;   Cholecystitis; Gallstone
  Intervention:   Procedure: Stent removal
  Sponsor:   Texas Tech University Health Sciences Center, El Paso
  Recruiting
• A Safety and Efficacy Study of IS-001 Injection in Patients Undergoing Robotic Hysterectomy

  NCT03937505

  Condition:   Ureter Injury
  Interventions:   Drug: IS-001;   Drug: No treatment
  Sponsor:   Intuitive Surgical
  Recruiting
• Comparison of Three Tissue Acquiring Techniques During EUS Guided Biopsies of Solid Pancreatic Tumors.

  NCT03264092

  Conditions:   Pancreatic Cancer;   Pancreatic Neoplasms
  Intervention:   Procedure: Endoscopic ultrasound guided fine needle biopsy
  Sponsor:   Texas Tech University Health Sciences Center, El Paso
  Recruiting
• Intracystic Injection of NanoPac® in Subjects With Mucinous Cystic Pancreatic Neoplasms

  NCT03188991

  Condition:   Pancreatic Mucinous-Cystic Neoplasm
  Intervention:   Drug: NanoPac®
  Sponsors:   NanOlogy, LLC;   US Biotest, Inc.
  Recruiting
• Trial of NanoPac® in Subjects With Locally Advanced Pancreatic Adenocarcinoma

  NCT03077685

  Condition:   Locally Advanced Pancreatic Adenocarcinoma
  Intervention:   Drug: NanoPac®
  Sponsors:   NanOlogy, LLC;   US Biotest, Inc.
  Recruiting
• Edtech-HPV: A Community Approach Using Education and Technology to Increase HPV Vaccination

  NCT03209713

  Condition:   Parents
  Interventions:   Behavioral: HPV Vaccine Education;   Behavioral: Text Messaging Reminder
  Sponsor:   Memorial Sloan Kettering Cancer Center
  Recruiting
• Bioequivalence Study of Ivermectin Cream 1% in Treatment of Moderate to Severe Facial Rosacea

  NCT04106726

  Condition:   Facial Rosacea
  Interventions:   Drug: Soolantra® Ivermectin cream 1%;   Drug: Ivermectin cream 1%;   Drug: Placebo for Ivermectin cream 1%
  Sponsors:   Zydus Worldwide DMCC;   Catawba Research, LLC
  Recruiting
• A Study of Verinurad and Allopurinol in Patients With Chronic Kidney Disease and Hyperuricaemia

  NCT03990363

  Condition:   Chronic Kidney Disease
  Interventions:   Drug: Verinurad;   Drug: Allopurinol;   Drug: Placebo for Verinurad;   Drug: Placebo for Allopurinol
  Sponsor:   AstraZeneca
  Recruiting
• MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study

  NCT03072927

  Condition:   Lumbar Spinal Stenosis
  Intervention:   Device: MILD
  Sponsor:   Vertos Medical, Inc.
  Recruiting
• Doxorubicin Hydrochloride and Cyclophosphamide Followed by Paclitaxel With or Without Carboplatin in Treating Patients With Triple-Negative Breast Cancer

  NCT02488967

  Conditions:   Breast Adenocarcinoma;   Estrogen Receptor Negative;   HER2/Neu Negative;   Progesterone Receptor Negative;   Stage IB Breast Cancer;   Stage IIA Breast Cancer;   Stage IIB Breast Cancer;   Stage IIIA Breast Cancer;   Stage IIIC Breast Cancer;   Triple-Negative Breast Carcinoma
  Interventions:   Drug: Carboplatin;   Drug: Cyclophosphamide;   Drug: Doxorubicin Hydrochloride;   Other: Laboratory Biomarker Analysis;   Drug: Paclitaxel
  Sponsors:   NRG Oncology;   National Cancer Institute (NCI)
  Recruiting
• Long-term Study to Evaluate and Clinical Outcomes in Patients With Favorable Intermediate Risk Localized Prostate Cancer

  NCT03290508

  Condition:   Prostate Cancer
  Intervention:   Diagnostic Test: Prolaris Testing
  Sponsor:   Myriad Genetic Laboratories, Inc.
  Recruiting
• Buspirone for Early Satiety and Symptoms of Gastroparesis

  NCT03587142

  Condition:   Gastroparesis
  Interventions:   Drug: Buspirone;   Drug: Placebo
  Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
  Recruiting
• A Study of Armour® Thyroid Compared to Synthetic T4 (Levothyroxine) in Previously Hypothyroid Participants

  NCT04124705

  Conditions:   Hypothyroidism;   Thyroid Disease;   Euthyroid;   Thyroid Gland;   Thyroid Hormones
  Interventions:   Drug: Armour® Thyroid;   Drug: Synthetic T4
  Sponsor:   Allergan
  Recruiting
• A Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of APP13007 to Treat Inflammation and Pain After Cataract Surgery

  NCT04089735

  Condition:   Ocular Inflammation and Pain
  Interventions:   Drug: APP13007, 0.05%;   Drug: APP13007, 0.1%;   Drug: APP13007 Placebo, 0.05%;   Drug: APP13007 Placebo, 0.1%
  Sponsor:   Formosa Pharmaceuticals, Inc.
  Recruiting
• CXA-10 Study in Subjects With Pulmonary Arterial Hypertension

  NCT04053543

  Condition:   PAH
  Intervention:   Drug: CXA-10
  Sponsors:   Complexa, Inc.;   Medpace, Inc.;   Innovative Analytics;   Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
  Recruiting
• Efficacy and Safety of Selonsertib in Participants With Moderate to Advanced Diabetic Kidney Disease

  NCT04026165

  Condition:   Diabetic Kidney Disease
  Interventions:   Drug: SEL;   Drug: Placebo
  Sponsor:   Gilead Sciences
  Recruiting
• An Investigational Study to Evaluate the Safety and Effectiveness of BMS-986165 With Background Treatment in Participants With Lupus Nephritis

  NCT03943147

  Condition:   Lupus Nephritis
  Interventions:   Drug: BMS-986165;   Drug: Placebo
  Sponsor:   Bristol-Myers Squibb
  Recruiting
• A Study of MD-7246 to Treat Abdominal Pain in Patients With Diarrhea-predominant Irritable Bowel Syndrome

  NCT03931785

  Condition:   Irritable Bowel Syndrome With Diarrhea (IBS-D)
  Interventions:   Drug: MD-7246;   Drug: Placebo
  Sponsors:   Ironwood Pharmaceuticals, Inc.;   Allergan Sales, LLC
  Recruiting
• A Study of JNJ-70033093 (BMS-986177) Versus Subcutaneous Enoxaparin in Participants Undergoing Elective Total Knee Replacement Surgery

  NCT03891524

  Condition:   Arthroplasty, Replacement, Knee
  Interventions:   Drug: JNJ-70033093 25 mg;   Drug: JNJ-70033093 50 mg;   Drug: JNJ-70033093 100 mg;   Drug: JNJ-70033093 200 mg;   Drug: Placebo;   Drug: Enoxaparin 40 mg
  Sponsors:   Janssen Research & Development, LLC;   Bristol-Myers Squibb
  Recruiting
• Comparison of SAR341402 to NovoLog in Adult Patients With Type 1 Diabetes Mellitus Also Using Insulin Glargine

  NCT03874715

  Condition:   Type 1 Diabetes Mellitus
  Interventions:   Drug: Insulin Aspart SAR341402;   Drug: Insulin Aspart;   Drug: Insulin glargine U100
  Sponsor:   Sanofi
  Recruiting
• A Research Study to See How Semaglutide Works Compared to Placebo in People With Type 2 Diabetes and Chronic Kidney Disease

  NCT03819153

  Condition:   Diabetes Mellitus, Type 2
  Interventions:   Drug: Semaglutide;   Drug: Placebo (semaglutide)
  Sponsor:   Novo Nordisk A/S
  Recruiting
• Safety, Tolerability and Efficacy of LMB763 in Patients With Diabetic Nephropathy

  NCT03804879

  Condition:   Diabetic Nephropathy
  Interventions:   Drug: LMB763;   Other: Placebo
  Sponsor:   Novartis Pharmaceuticals
  Recruiting
• Study of Vadadustat in Hemodialysis Patients With Anemia Switching From Epoetin Alfa

  NCT03799627

  Conditions:   Anemia;   Dialysis-dependent Chronic Kidney Disease
  Interventions:   Drug: Vadadustat;   Drug: Epoetin Alfa;   Drug: Vadadustat TIW
  Sponsor:   Akebia Therapeutics
  Recruiting
• End-stage Renal Disease (ESRD) Pilot Study

  NCT03787368

  Condition:   Renal Dialysis
  Interventions:   Drug: BAY1213790;   Drug: 0.9% sodium chloride solution
  Sponsor:   Bayer
  Recruiting
• A Study on BMS-986177 for the Prevention of a Stroke in Patients Receiving Aspirin and Clopidogrel

  NCT03766581

  Conditions:   Acute Ischemic Stroke;   Transient Ischemic Attack (TIA)
  Interventions:   Drug: BMS-986177;   Other: Placebo;   Drug: Clopidogrel;   Drug: Aspirin
  Sponsors:   Bristol-Myers Squibb;   Janssen, LP
  Recruiting
• A Study of the Efficacy and Safety of Relacorilant in Patients With Endogenous Cushing Syndrome

  NCT03697109

  Condition:   Cushing Syndrome
  Interventions:   Drug: Relacorilant;   Other: Placebo
  Sponsor:   Corcept Therapeutics
  Recruiting
• GB001 in Adult Subjects With Moderate to Severe Asthma

  NCT03683576

  Condition:   Asthma
  Interventions:   Drug: GB001;   Drug: Placebo Oral Tablet
  Sponsor:   GB001, Inc, a wholly owned subsidiary of Gossamer Bio, Inc.
  Recruiting
• Long-term Safety, Tolerability and Effectiveness Study of Ofatumumab in Patients With Relapsing MS

  NCT03650114

  Condition:   Relapsing Multiple Sclerosis
  Interventions:   Biological: Ofatumumab;   Biological: Tetanus toxoid (TT) containing vaccine (Td, Tdap);   Biological: 13-valent pneumococcal conjugate vaccine (13-PCV);   Biological: 23-valent pneumococcal polysaccharide vaccine (23-PPV);   Biological: Seasonal Quadrivalent influenza vaccine;   Biological: Keyhole limpet hemocyanin (KLH) neo-antigen
  Sponsor:   Novartis Pharmaceuticals
  Recruiting
• Safety and Efficacy of KPI-121 in Subjects With DED

  NCT03616899

  Condition:   Kerato Conjunctivitis Sicca
  Interventions:   Drug: KPI-121 Ophthalmic Suspension;   Drug: Vehicle
  Sponsor:   Kala Pharmaceuticals, Inc.
  Recruiting
• Dose-Exploration Evaluating the Efficacy and Safety of Voclosporin in Subjects With Focal Segmental Glomerulosclerosis

  NCT03598036

  Condition:   Focal Segmental Glomerulosclerosis
  Intervention:   Drug: Voclosporin
  Sponsor:   Aurinia Pharmaceuticals Inc.
  Recruiting
• EMPA-KIDNEY (The Study of Heart and Kidney Protection With Empagliflozin)

  NCT03594110

  Condition:   Chronic Kidney Disease
  Interventions:   Drug: Empagliflozin;   Drug: Matching placebo
  Sponsors:   Boehringer Ingelheim;   Medical Research Council Population Health Research Unit, CTSU, University of Oxford (academic lead);   Eli Lilly and Company
  Recruiting
• Trial of IW-3718 for 8 Weeks in Patients With Persistent Gastroesophageal Reflux Disease (GERD) Receiving Proton Pump Inhibitors

  NCT03561883

  Condition:   Gastroesophageal Reflux Disease (GERD)
  Interventions:   Drug: IW-3718;   Drug: placebo
  Sponsor:   Ironwood Pharmaceuticals, Inc.
  Recruiting
• A Study to Evaluate the Efficacy and Safety of TAK-906 in Adult Participants With Symptomatic Idiopathic or Diabetic Gastroparesis

  NCT03544229

  Conditions:   Diabetic Gastroparesis;   Idiopathic Gastroparesis
  Interventions:   Drug: TAK-906 Maleate;   Drug: TAK-906 Maleate Placebo
  Sponsor:   Millennium Pharmaceuticals, Inc.
  Recruiting
• A Phase 3 Adaptive Study to Evaluate the Safety and Efficacy of Inhaled Treprostinil in Patients With PH Due to COPD

  NCT03496623

  Conditions:   Pulmonary Hypertension;   Chronic Obstructive Pulmonary Disease
  Interventions:   Drug: Inhaled treprostinil solution;   Drug: Placebo solution
  Sponsor:   United Therapeutics
  Recruiting
• PRIMEx - A Study of 2 Doses of Oral CXA-10 in Pulmonary Arterial Hypertension (PAH)

  NCT03449524

  Condition:   PAH
  Interventions:   Drug: 75mg CXA-10;   Drug: 150mg CXA-10;   Other: Placebo
  Sponsors:   Complexa, Inc.;   Medpace, Inc.;   Philips Healthcare;   Cardiovascular Clinical Science Foundation;   MicroConstants;   Innovative Analytics;   Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
  Recruiting
• Study to Evaluate the Safety and Efficacy of Relamorelin in Patients With Diabetic Gastroparesis Study 02

  NCT03426345

  Conditions:   Gastroparesis;   Diabetes Mellitus
  Interventions:   Drug: Relamorelin;   Drug: Placebo
  Sponsor:   Allergan
  Recruiting
• FIRSTx - A Study of Oral CXA-10 in Primary Focal Segmental Glomerulosclerosis (FSGS)

  NCT03422510

  Condition:   Primary Focal Segmental Glomerulosclerosis
  Intervention:   Drug: CXA-10
  Sponsors:   Complexa, Inc.;   Kidney Research Network, formerly NephCure Accelerating Cures Institute;   Medpace, Inc.;   MicroConstants;   Arkana Labs;   NephCure Kidney International
  Recruiting
• Anemia Studies in Chronic Kidney Disease (CKD): Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor (PHI) Daprodustat in Non-Dialysis Subjects Evaluating Hemoglobin (Hgb) and Quality of Life (ASCEND-NHQ)

  NCT03409107

  Condition:   Anaemia
  Interventions:   Drug: Daprodustat (GSK1278863);   Drug: Placebo;   Drug: Iron therapy
  Sponsor:   GlaxoSmithKline
  Recruiting
• Talazoparib + Enzalutamide vs. Enzalutamide Monotherapy in mCRPC

  NCT03395197

  Condition:   mCRPC
  Interventions:   Drug: Talazoparib with enzalutamide;   Drug: Placebo with enzalutamide
  Sponsors:   Pfizer;   Astellas Pharma Inc
  Recruiting
• A Safety and Efficacy Study of Relamorelin in Diabetic Gastroparesis Study 04

  NCT03383146

  Conditions:   Gastroparesis;   Diabetes Mellitus
  Interventions:   Drug: Relamorelin;   Drug: Placebo
  Sponsor:   Allergan
  Recruiting
• Effect of Tumor Treating Fields (TTFields, 150 kHz) as Front-Line Treatment of Locally-advanced Pancreatic Adenocarcinoma Concomitant With Gemcitabine and Nab-paclitaxel (PANOVA-3)

  NCT03377491

  Condition:   Pancreas Adenocarcinoma
  Interventions:   Device: NovoTTF-100L(P);   Drug: Gemcitabine;   Drug: nab paclitaxel
  Sponsor:   NovoCure Ltd.
  Recruiting
• Palbociclib in Real World Practice

  NCT03280303

  Conditions:   Advanced Breast Cancer;   Metastatic Breast Cancer
  Intervention:   Other: non-interventional
  Sponsor:   Pfizer
  Recruiting
• Stellarex DCB Versus Standard Balloon Angioplasty for Treatment of Below-The-Knee (BTK) Arteries

  NCT03175744

  Condition:   Critical Limb Ischemia
  Interventions:   Device: Stellarex DCB;   Device: PTA Catheter
  Sponsor:   Spectranetics Corporation
  Recruiting
• An Effectiveness and Safety Study of Ixazomib in Combination With Lenalidomide and Dexamethasone (IRD) in Participants With Multiple Myeloma (MM) Previously Receiving a Bortezomib-based Induction Regimen (US MM-6)

  NCT03173092

  Condition:   Multiple Myeloma
  Interventions:   Drug: Ixazomib;   Drug: Lenalidomide;   Drug: Dexamethasone
  Sponsor:   Millennium Pharmaceuticals, Inc.
  Recruiting
• Extended Access Program to Assess Long-term Safety of Bardoxolone Methyl in Patients With Pulmonary Hypertension RANGER

  NCT03068130

  Condition:   Pulmonary Hypertension
  Intervention:   Drug: Bardoxolone methyl
  Sponsor:   Reata Pharmaceuticals, Inc.
  Recruiting
• A Study to Evaluate the Effect of Dapagliflozin on Renal Outcomes and Cardiovascular Mortality in Patients With Chronic Kidney Disease

  NCT03036150

  Condition:   Chronic Kidney Disease
  Interventions:   Drug: Dapagliflozin;   Drug: Placebo
  Sponsor:   AstraZeneca
  Recruiting
• QUILT-3.032: A Multicenter Clinical Trial of Intravesical Bacillus Calmette-Guerin (BCG) in Combination With ALT-803 in Patients With BCG Unresponsive High Grade Non-Muscle Invasive Bladder Cancer

  NCT03022825

  Condition:   Bladder Cancer
  Interventions:   Drug: ALT-803;   Drug: BCG
  Sponsor:   Altor BioScience
  Recruiting
• TARGET Post-Approval Study

  NCT02800863

  Condition:   Complex Regional Pain Syndrome (CRPS)
  Interventions:   Device: Dorsal Root Ganglion (DRG) Stimulation (Axium™ Neurostimulator System);   Device: Dorsal Root Ganglion (DRG) Stimulation (Proclaim™ Neurostimulator System)
  Sponsor:   Abbott Medical Devices
  Recruiting
• A Dose Ranging Study Evaluating Efficacy and Safety of NI-03

  NCT02693093

  Condition:   Chronic Pancreatitis
  Interventions:   Drug: NI-03;   Drug: Placebo
  Sponsor:   Kangen Pharmaceuticals, Inc
  Recruiting
• The PARTNER 3 - Trial - The Safety and Effectiveness of the SAPIEN 3 Transcatheter Heart Valve in Low Risk Patients With Aortic Stenosis

  NCT02675114

  Condition:   Aortic Stenosis
  Interventions:   Procedure: Surgical aortic valve replacement (SAVR);   Device: Transcatheter Aortic Valve Replacement (TAVR)
  Sponsor:   Edwards Lifesciences
  Recruiting
• A Comparison of Bimatoprost SR to Selective Laser Trabeculoplasty in Patients With Open-Angle Glaucoma or Ocular Hypertension

  NCT02636946

  Conditions:   Glaucoma;   Open-Angle Ocular Hypertension
  Interventions:   Drug: Bimatoprost SR;   Drug: Sham Bimatoprost SR;   Procedure: Selective Laser Trabeculoplasty;   Procedure: Sham Selective Laser Trabeculoplasty
  Sponsor:   Allergan
  Recruiting
• Safety and Efficacy of Inhaled Treprostinil in Adult PH With ILD Including CPFE

  NCT02630316

  Conditions:   Pulmonary Hypertension;   Interstitial Lung Disease;   Combined Pulmonary Fibrosis and Emphysema
  Interventions:   Drug: Inhaled Treprostinil;   Drug: Placebo
  Sponsor:   United Therapeutics
  Recruiting
• CLUSTER Trial for Outbreak Detection and Response

  NCT04053075

  Condition:   Cluster Detection
  Interventions:   Other: Routine cluster detection;   Other: Enhanced cluster detection
  Sponsors:   Harvard Pilgrim Health Care;   Hospital Corporation of America (HCA) Healthcare;   Brigham and Women's Hospital;   University of California, Irvine;   Harvard School of Public Health;   Rush University;   Duke University;   University of Massachusetts, Amherst;   University of California, San Francisco;   Cook County Health & Hospitals System;   Centers for Disease Control and Prevention
  Recruiting
• A Phase III Study Assessing the Efficacy and Safety of DE-117 Ophthalmic Solution Compared With Timolol Maleate Ophthalmic Solution 0.5% in Subjects With Glaucoma or Ocular Hypertension - Spectrum 3 Study

  NCT03691649

  Condition:   Glaucoma and Ocular Hypertension
  Interventions:   Drug: DE-117 Ophthalmic Solution;   Drug: Timolol Maleate Ophthalmic Solution 0.5%
  Sponsor:   Santen Inc.
  Recruiting
• A 5-year Longitudinal Observational Study of Patients Undergoing Therapy for IMISC

  NCT03661866

  Conditions:   Atopic Dermatitis;   Alopecia;   Hidradenitis Suppurativa;   Vitiligo;   Psoriasis
  Intervention:  
  Sponsor:   Target PharmaSolutions, Inc.
  Recruiting
• Axitinib and Nivolumab in Treating Patients With Unresectable or Metastatic TFE/Translocation Renal Cell Carcinoma

  NCT03595124

  Conditions:   Metastatic Renal Cell Carcinoma;   Renal Cell Carcinoma Associated With Xp11.2 Translocations/TFE3 Gene Fusions;   Stage III Renal Cell Cancer AJCC v8;   Stage IV Renal Cell Cancer AJCC v8;   Unresectable Renal Cell Carcinoma
  Interventions:   Drug: Axitinib;   Biological: Nivolumab
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• A Phase III Study of Efficacy and Safety of Ligelizumab in the Treatment of CSU in Adolescents and Adults Inadequately Controlled With H1-antihistamines.

  NCT03580356

  Condition:   Chronic Spontaneous Urticaria
  Interventions:   Biological: Ligelizumab;   Biological: Omalizumab;   Other: Placebo
  Sponsor:   Novartis Pharmaceuticals
  Recruiting
• Study of Sparsentan in Patients With Primary Focal Segmental Glomerulosclerosis (FSGS)

  NCT03493685

  Condition:   Focal Segmental Glomerulosclerosis
  Interventions:   Drug: sparsentan;   Drug: irbesartan
  Sponsor:   Retrophin, Inc.
  Recruiting
• Carvedilol in Preventing Heart Failure in Childhood Cancer Survivors

  NCT02717507

  Condition:   Cancer Survivor
  Interventions:   Drug: Carvedilol;   Other: Laboratory Biomarker Analysis;   Other: Pharmacogenomic Study;   Other: Pharmacological Study;   Other: Placebo;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration
  Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• A Registry for Patients With Chronic Hypoparathyroidism

  NCT01922440

  Condition:   Chronic Hypoparathyroidism
  Intervention:   Drug: Combination product (Natpara) and drug or supplements [Disease and drug registry]
  Sponsor:   Shire
  Recruiting