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• Effect of Dry Roasted Peanuts and Boiled Peanuts on Glycemic Control

  NCT04171648

  Conditions:   Diabetes Mellitus;   Glycemic Control
  Interventions:   Other: Roasted Peanut Treatment;   Other: Boiled Peanut Treatment
  Sponsor:   North Carolina State University
  Recruiting
• Observational Study Evaluating the Safety of ADASUVE® in Agitation Associated With Schizophrenia or Bipolar I Disorder

  NCT03513549

  Condition:   Agitation,Psychomotor
  Intervention:   Drug: Loxapine 10 MG
  Sponsors:   Galen Limited;   Pharmaceutical Research Associates
  Recruiting
• Assisting Smokers to Switch to a JUUL E-Cigarette by Devaluing Combustible Cigarettes

  NCT04188197

  Conditions:   Smoking Cessation;   Harm Reduction;   E-Cig Use;   Cigarette Smoking;   Tobacco Dependence;   Tobacco Use Cessation
  Intervention:   Other: JUUL
  Sponsors:   Rose Research Center, LLC;   Foundation for a Smoke-Free World
  Recruiting
• Optimizing Overactive Bladder Treatment

  NCT03904407

  Condition:   Overactive Bladder
  Interventions:   Other: Lactobacillus Probiotic Capsule;   Other: Matching Lactobacillus Probiotic Placebo Capsule
  Sponsors:   University of North Carolina, Chapel Hill;   Society of Urodynamics, Female Pelvic Medicine and Urogenital Reconstruction
  Recruiting
• Development of a Cabozantinib (Cabometyx) Symptom Management Application for Use in Patients With Renal Cancer

  NCT03867045

  Condition:   Metastatic Renal Cell Carcinoma Treated With Cabozantinib
  Intervention:   Device: Usability of an electronic symptom management application
  Sponsors:   Duke University;   Exelixis
  Recruiting
• Abuse Liability of Reduced Nicotine Content Cigarettes in the Context of Concurrent E-Cigarette Use

  NCT02870218

  Conditions:   Nicotine Addiction;   Cigarette Smoking
  Interventions:   Drug: Smoking research cigarettes with e-cigarette;   Drug: Nicotine discrimination thresholds
  Sponsors:   Rose Research Center, LLC;   National Institutes of Health (NIH);   Food and Drug Administration (FDA);   National Institute on Drug Abuse (NIDA)
  Recruiting
• Longitudinal Effects of a Sexual Health Intervention: HEART

  NCT04156516

  Conditions:   STD;   Adolescent Behavior
  Interventions:   Behavioral: HEART;   Behavioral: HealthyMinds
  Sponsor:   North Carolina State University
  Recruiting
• Placebo Controlled, Multiple Ascending Dose Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of SAP-001 in Gout Patients

  NCT04040816

  Conditions:   Gout;   Hyperuricemia
  Intervention:   Drug: SAP-001
  Sponsor:   Shanton Pharma Co., Ltd.
  Recruiting
• Study of Efficacy and Safety of LOU064 in Inadequately Controlled Asthma Patients

  NCT03944707

  Condition:   Asthma
  Intervention:   Drug: LOU064 or placebo treatment
  Sponsor:   Novartis Pharmaceuticals
  Recruiting
• P53 Mutational Status and cf HPV DNA for the Management of HPV-associated OPSCC

  NCT03077243

  Conditions:   Carcinoma, Squamous Cell;   Head and Neck Neoplasms;   Oropharyngeal Neoplasms
  Interventions:   Radiation: Intensity Modulated Radiotherapy (IMRT) - deintensified;   Radiation: Intensity Modulated Radiotherapy (IMRT) - standard;   Drug: Cisplatin (or alternative) - deintensified;   Drug: Cisplatin (or alternative) - standard;   Procedure: Assessment for surgical evaluation
  Sponsor:   UNC Lineberger Comprehensive Cancer Center
  Recruiting
• Environmental Polymorphisms Registry

  NCT00341237

  Conditions:   Diabetes;   Heart Disease;   Asthma
  Intervention:  
  Sponsor:   National Institute of Environmental Health Sciences (NIEHS)
  Recruiting
• Pharmacokinetics of Dabrafenib in Subjects With Renal Impairment

  NCT02852239

  Condition:   Renal Impairment
  Intervention:   Drug: dabrafenib
  Sponsor:   Novartis Pharmaceuticals
  Recruiting
• Breast Cancer WEight Loss Study (BWEL Study)

  NCT02750826

  Condition:   Breast Carcinoma
  Interventions:   Other: Health Education Program;   Other: Weight Loss Intervention
  Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI);   Division of Cancer Control;   NIH Biomarker, Imaging and Quality of Life Studies Funding Program (BIQSFP);   Canadian Cancer Trials Group
  Recruiting
• Aspirin in Preventing Recurrence of Cancer in Patients With HER2 Negative Stage II-III Breast Cancer After Chemotherapy, Surgery, and/or Radiation Therapy

  NCT02927249

  Condition:   Node Positive HER2 Negative Breast Cancer
  Interventions:   Other: Placebo;   Drug: Aspirin
  Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI);   United States Department of Defense;   Bayer;   Canadian Cancer Trials Group
  Recruiting
• Clinical Trial of Neoadjuvant Chemotherapy With Atezolizumab or Placebo in Patients With Triple-Negative Breast Cancer Followed After Surgery by Atezolizumab or Placebo

  NCT03281954

  Condition:   Triple Negative Breast Cancer
  Interventions:   Drug: Placebo;   Drug: Atezolizumab
  Sponsors:   NSABP Foundation Inc;   Genentech, Inc.;   Hoffmann-La Roche
  Recruiting
• Evaluation of Major Cardiovascular Events in Patients With, or at High Risk for, Cardiovascular Disease Who Are Statin Intolerant Treated With Bempedoic Acid (ETC-1002) or Placebo

  NCT02993406

  Conditions:   Cardiovascular Diseases;   Statin Adverse Reaction
  Interventions:   Drug: Bempedoic acid 180 mg tablet;   Drug: Matching placebo tablet
  Sponsors:   Esperion Therapeutics;   The Cleveland Clinic
  Recruiting
• Doxorubicin Hydrochloride and Cyclophosphamide Followed by Paclitaxel With or Without Carboplatin in Treating Patients With Triple-Negative Breast Cancer

  NCT02488967

  Conditions:   Breast Adenocarcinoma;   Estrogen Receptor Negative;   HER2/Neu Negative;   Progesterone Receptor Negative;   Stage IB Breast Cancer;   Stage IIA Breast Cancer;   Stage IIB Breast Cancer;   Stage IIIA Breast Cancer;   Stage IIIC Breast Cancer;   Triple-Negative Breast Carcinoma
  Interventions:   Drug: Carboplatin;   Drug: Cyclophosphamide;   Drug: Doxorubicin Hydrochloride;   Other: Laboratory Biomarker Analysis;   Drug: Paclitaxel
  Sponsors:   NRG Oncology;   National Cancer Institute (NCI)
  Recruiting
• Standard of Care Therapy With or Without Stereotactic Radiosurgery and/or Surgery in Treating Patients With Limited Metastatic Breast Cancer

  NCT02364557

  Conditions:   Dyspnea;   Fatigue;   Nausea and Vomiting;   Pain;   Stage IV Breast Cancer
  Interventions:   Radiation: Stereotactic Radiosurgery;   Procedure: Therapeutic Conventional Surgery;   Other: Laboratory Biomarker Analysis
  Sponsors:   NRG Oncology;   National Cancer Institute (NCI)
  Recruiting
• A Study to Find Out How Safe Long-term Treatment With Fezolinetant is in Women With Hot Flashes Going Through Menopause

  NCT04003389

  Condition:   Hot Flashes
  Interventions:   Drug: fezolinetant;   Drug: placebo
  Sponsor:   Astellas Pharma Global Development, Inc.
  Recruiting
• A Study to Find Out if Fezolinetant Helps Reduce Moderate to Severe Hot Flashes in Women Going Through Menopause

  NCT04003155

  Condition:   Hot Flashes
  Interventions:   Drug: fezolinetant;   Drug: placebo
  Sponsor:   Astellas Pharma Global Development, Inc.
  Recruiting
• A Study to Assess the Safety and Effectiveness of Pridopidine Compared to Placebo in the Treatment of Levodopa-Induced Dyskinesia in Patients With Parkinson's Disease

  NCT03922711

  Condition:   Parkinson Disease
  Interventions:   Drug: Pridopidine;   Drug: Placebo
  Sponsor:   Prilenia
  Recruiting
• To Evaluate the Safety and Tolerability of Atogepant 10mg, 30 mg and 60 mg Once a Day for the Prevention of Migraine in Participants With Episodic Migraine

  NCT03777059

  Condition:   Episodic Migraine
  Interventions:   Drug: Atogepant 30 mg;   Drug: Atogepant 60 mg;   Drug: Placebo;   Drug: Atogepant 10 mg
  Sponsor:   Allergan
  Recruiting
• A Trial of IW-3718 for 8 Weeks in Patients With Persistent Gastroesophageal Reflux Disease (GERD) Receiving Proton Pump Inhibitors

  NCT03561090

  Condition:   Gastroesophageal Reflux Disease (GERD)
  Interventions:   Drug: IW-3718;   Drug: placebo
  Sponsor:   Ironwood Pharmaceuticals, Inc.
  Recruiting
• The DES BTK Vascular Stent System vs PTA in Subjects With Critical Limb Ischemia

  NCT03551496

  Condition:   Critical Limb Ischemia
  Interventions:   Combination Product: Drug Eluting Stent - Below the Knee;   Device: Standard PTA Control Arm
  Sponsor:   Boston Scientific Corporation
  Recruiting
• Hemodynamic-GUIDEd Management of Heart Failure

  NCT03387813

  Conditions:   Heart Failure;   Heart Failure, Systolic;   Heart Failure, Diastolic;   Heart Failure NYHA Class II;   Heart Failure NYHA Class III;   Heart Failure NYHA Class IV;   Heart Failure，Congestive;   Heart Failure With Reduced Ejection Fraction;   Heart Failure With Normal Ejection Fraction;   Heart Failure; With Decompensation
  Intervention:   Device: CardioMEMS™ HF System
  Sponsor:   Abbott Medical Devices
  Recruiting
• Care Optimization Through Patient and Hospital Engagement Clinical Trial for Heart Failure

  NCT03035474

  Condition:   Heart Failure
  Interventions:   Other: Digital Engagement;   Other: Direct Engagement
  Sponsors:   Duke University;   Duke Clinical Research Institute
  Recruiting
• Shockwave Medical Peripheral Lithoplasty System Study for PAD (Disrupt PAD III)

  NCT02923193

  Condition:   Peripheral Arterial Disease
  Interventions:   Device: Shockwave Lithoplasty® Peripheral Lithoplasty System;   Drug: Medtronic IN.PACT (DCB)
  Sponsor:   Shockwave Medical, Inc.
  Recruiting
• Safety and Efficacy Study of JNJ-64304500 in Participants With Moderately to Severely Active Crohn's Disease

  NCT02877134

  Condition:   Crohn Disease
  Interventions:   Drug: JNJ-64304500;   Drug: Placebo;   Drug: Ustekinumab
  Sponsor:   Janssen Research & Development, LLC
  Recruiting
• Long-term Study to Evaluate and Clinical Outcomes in Patients With Favorable Intermediate Risk Localized Prostate Cancer

  NCT03290508

  Condition:   Prostate Cancer
  Intervention:   Diagnostic Test: Prolaris Testing
  Sponsor:   Myriad Genetic Laboratories, Inc.
  Recruiting
• Evaluation of Transcatheter Aortic Valve Replacement Compared to SurveilLance for Patients With AsYmptomatic Severe Aortic Stenosis

  NCT03042104

  Conditions:   Aortic Stenosis;   Heart Diseases
  Intervention:   Device: Edwards SAPIEN 3 THV
  Sponsor:   Edwards Lifesciences
  Recruiting
• Registry of Older Patients With Cancer

  NCT01137825

  Conditions:   Chronic Myeloproliferative Disorders;   Cognitive/Functional Effects;   Leukemia;   Lymphoma;   Lymphoproliferative Disorder;   Multiple Myeloma and Plasma Cell Neoplasm;   Myelodysplastic Syndromes;   Myelodysplastic/Myeloproliferative Neoplasms;   Unspecified Adult Solid Tumor, Protocol Specific
  Intervention:  
  Sponsors:   UNC Lineberger Comprehensive Cancer Center;   National Cancer Institute (NCI)
  Recruiting
• Transvenous Lead Removal Post-Market Clinical Study

  NCT03688412

  Condition:   Cardiac Electrophysiology
  Intervention:   Device: Cook lead extraction devices
  Sponsor:   Cook Research Incorporated
  Recruiting
• Rucaparib in Treating Patients With Genomic LOH High and/or Deleterious BRCA1/2 Mutation Stage IV or Recurrent Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial)

  NCT03845296

  Conditions:   Deleterious BRCA1 Gene Mutation;   Deleterious BRCA2 Gene Mutation;   Loss of Heterozygosity;   Lung Non-Small Cell Squamous Carcinoma;   Recurrent Large Cell Lung Carcinoma;   Recurrent Lung Adenocarcinoma;   Recurrent Lung Non-Small Cell Carcinoma;   Recurrent Non-Squamous Non-Small Cell Lung Carcinoma;   Stage IV Lung Cancer AJCC v8;   Stage IVA Lung Cancer AJCC v8;   Stage IVB Lung Cancer AJCC v8
  Intervention:   Drug: Rucaparib
  Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• Comparative Effectiveness Study Telerehab Versus Conventional

  NCT03468868

  Condition:   Multiple Sclerosis
  Intervention:   Behavioral: Exercise program for people with MS
  Sponsors:   Shepherd Center, Atlanta GA;   University of Alabama at Birmingham;   University of North Carolina, Chapel Hill;   University of Georgia;   The Cleveland Clinic;   University of Colorado, Denver;   Marquette University;   Accelerated Cure Project for Multiple Sclerosis;   Patient-Centered Outcomes Research Institute
  Recruiting
• A Registry for Hereditary Cancer Risk Assessment and Genetic Testing

  NCT04015102

  Condition:   Prostate Cancer
  Intervention:  
  Sponsors:   Myriad Genetic Laboratories, Inc.;   Carolina Urologic Research Center
  Recruiting
• AltaValve Early Feasibility Study Protocol

  NCT03997305

  Conditions:   Mitral Regurgitation;   Mitral Insufficiency;   Mitral Valve Incompetence;   Mitral Valve Regurgitation;   Mitral Incompetence
  Intervention:   Device: AltaValve
  Sponsor:   4C Medical Technologies, Inc.
  Recruiting
• A Study To Evaluate The Efficacy And Safety Of TNX-102 SL In Patients With Fibromyalgia

  NCT04172831

  Condition:   Fibromyalgia
  Interventions:   Drug: TNX-102 SL;   Drug: Placebo SL Tablet
  Sponsor:   Tonix Pharmaceuticals, Inc.
  Recruiting
• Study to Assess the Safety and Immunogenicity of a Single Dose of a Quadrivalent Meningococcal (MenACYW) Conjugate Vaccine in Older Adults Who Received a Primary Vaccination (3 or More Years Earlier) in Study MET49

  NCT04142242

  Condition:   Meningococcal Infection (Healthy Volunteers)
  Interventions:   Biological: Meningococcal polysaccharide (serogroups A, C, Y, and W) tetanus toxoid conjugate vaccine MenACYW conjugate vaccine;   Other: Blood sample
  Sponsor:   Sanofi Pasteur, a Sanofi Company
  Recruiting
• Evaluating the Safety and Efficacy of Tradipitant vs. Placebo in Idiopathic and Diabetic Gastroparesis

  NCT04028492

  Conditions:   Idiopathic Gastroparesis;   Diabetic Gastroparesis;   Gastroparesis
  Interventions:   Drug: Tradipitant;   Drug: Placebo
  Sponsor:   Vanda Pharmaceuticals
  Recruiting
• Study of Azeliragon in Patients With Mild Alzheimer's Disease and Impaired Glucose Tolerance

  NCT03980730

  Condition:   Alzheimer Disease
  Interventions:   Drug: Azeliragon;   Drug: Placebo
  Sponsor:   vTv Therapeutics
  Recruiting
• A Study to Test the Effectiveness and Safety of Fremanezumab on Patients With Fibromyalgia

  NCT03965091

  Condition:   Fibromyalgia
  Interventions:   Drug: Fremanezumab - Dose A;   Drug: Fremanezumab - Dose B;   Drug: Placebo
  Sponsor:   Teva Branded Pharmaceutical Products, R&D Inc.
  Recruiting
• Once-Nightly Sodium Oxybate for Treatment of Excessive Daytime Sleepiness and Cataplexy in Narcolepsy

  NCT02720744

  Conditions:   Excessive Daytime Sleepiness;   Cataplexy;   Narcolepsy
  Interventions:   Drug: Sodium Oxybate;   Drug: Placebo
  Sponsor:   Avadel
  Recruiting
• A Study of Suboptimally Controlled Participants Previously Taking Oral or Infusion Disease-Modifying Drugs (DMDs) for Relapsing Forms of Multiple Sclerosis (RMS)

  NCT03933202

  Condition:   Multiple Sclerosis
  Intervention:   Drug: Cladribine Tablets
  Sponsors:   EMD Serono Research & Development Institute, Inc.;   Merck KGaA, Darmstadt, Germany
  Recruiting
• A Study of MD-7246 to Treat Abdominal Pain in Patients With Diarrhea-predominant Irritable Bowel Syndrome

  NCT03931785

  Condition:   Irritable Bowel Syndrome With Diarrhea (IBS-D)
  Interventions:   Drug: MD-7246;   Drug: Placebo
  Sponsors:   Ironwood Pharmaceuticals, Inc.;   Allergan Sales, LLC
  Recruiting
• Clostridium Difficile Vaccine 2-Dose Versus 3-Dose Study

  NCT03918629

  Condition:   Clostridium Difficile Associated Disease
  Interventions:   Biological: Clostridium difficile;   Biological: Placebo
  Sponsor:   Pfizer
  Recruiting
• Study to Evaluate the Efficacy, Safety and Tolerability of Vibegron in Men With Overactive Bladder (OAB) Symptoms on Pharmacological Therapy for Benign Prostatic Hyperplasia (BPH)

  NCT03902080

  Condition:   Overactive Bladder
  Interventions:   Drug: Vibegron;   Drug: Placebo
  Sponsor:   Urovant Sciences GmbH
  Recruiting
• A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate STS101 in the Acute Treatment of Migraine

  NCT03901482

  Conditions:   Migraine;   Migraine With Aura;   Migraine Without Aura
  Interventions:   Drug: Dihydroergotamine;   Drug: Placebos
  Sponsor:   Satsuma Pharmaceuticals, Inc.
  Recruiting
• A Study of Baricitinib (LY3009104) in Adults With Severe or Very Severe Alopecia Areata

  NCT03899259

  Condition:   Alopecia Areata
  Interventions:   Drug: Baricitinib;   Drug: Placebo
  Sponsors:   Eli Lilly and Company;   Incyte Corporation
  Recruiting
• An Extension Study of MOM-M281-004 to Evaluate the Safety, Tolerability, and Efficacy of M281 Administered to Patients With Generalized Myasthenia Gravis

  NCT03896295

  Condition:   Generalized Myasthenia Gravis
  Intervention:   Drug: M281
  Sponsor:   Momenta Pharmaceuticals, Inc.
  Recruiting
• Efficacy, Safety, and Tolerability of Atogepant for the Prevention of Chronic Migraine

  NCT03855137

  Condition:   Chronic Migraine
  Interventions:   Drug: Atogepant 30 mg;   Drug: Atogepant 60 mg;   Drug: Placebo
  Sponsor:   Allergan
  Recruiting
• Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

  NCT03851445

  Condition:   Previously Treated Non-Small Cell Lung Cancer
  Intervention:   Drug: Screening Platform
  Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• Dose Ranging Study To Assess Efficacy, Safety and Tolerability Of PF-06700841 Topical Cream In Psoriasis

  NCT03850483

  Condition:   Psoriasis
  Interventions:   Drug: PF-06700841;   Drug: Vehicle (Placebo)
  Sponsor:   Pfizer
  Recruiting
• XIENCE 28 USA Study

  NCT03815175

  Conditions:   Bleeding Disorder;   Ischemic Stroke;   Hemorrhagic Stroke;   Hematological Diseases;   Thrombocytopenia;   Coagulation Disorder;   Anemia;   Renal Insufficiency;   Coronary Artery Disease
  Interventions:   Device: XIENCE;   Drug: DAPT (aspirin and/or P2Y12 receptor inhibitor)
  Sponsor:   Abbott Medical Devices
  Recruiting
• A Single Ascending Dose Study in Adults (Stage 1) and Single Ascending Dose-Finding Study (Stage 2) in Elderly Subjects With ASP3772, A Pneumococcal Vaccine

  NCT03803202

  Conditions:   Healthy Volunteers;   Pneumococcal Disease
  Interventions:   Biological: ASP3772;   Biological: PCV13;   Biological: PPSV23
  Sponsors:   Astellas Pharma Global Development, Inc.;   Affinivax
  Recruiting
• Orally Administered ENT-01 for Parkinson's Disease-Related Constipation (KARMET)

  NCT03781791

  Conditions:   Constipation;   Parkinson Disease
  Interventions:   Drug: Active Investigational Treatment ENT-01;   Drug: Placebo Treatment
  Sponsor:   Enterin Inc.
  Recruiting
• A Study to Evaluate the Safety and Tolerability of ABBV-951 in Subjects With Parkinson's Disease (PD)

  NCT03781167

  Condition:   Parkinson's Disease (PD)
  Intervention:   Drug: ABBV-951
  Sponsor:   AbbVie
  Recruiting
• A Study to Evaluate the Safety, Tolerability, Efficacy, Pharmacokinetics and Pharmacodynamics of M281 Administered to Adults With Generalized Myasthenia Gravis

  NCT03772587

  Condition:   Generalized Myasthenia Gravis
  Interventions:   Drug: M281;   Other: Placebo
  Sponsor:   Momenta Pharmaceuticals, Inc.
  Recruiting
• Study to Assess the Effect of Omecamtiv Mecarbil on Exercise Capacity in Subjects With Heart Failure

  NCT03759392

  Condition:   Heart Failure With Reduced Ejection Fraction
  Interventions:   Drug: Omecamtiv Mecarbil;   Drug: Placebo
  Sponsors:   Amgen;   Cytokinetics;   Servier
  Recruiting
• A Study to Assess Efficacy and Safety of SER‑287 in Adults With Active Mild-to-Moderate Ulcerative Colitis

  NCT03759041

  Condition:   Ulcerative Colitis
  Interventions:   Drug: Vancomycin Pre-Treatment;   Drug: Placebo for Vancomycin Pre-Treatment;   Drug: SER-287;   Drug: Placebo for SER-287
  Sponsor:   Seres Therapeutics, Inc.
  Recruiting
• A Study to Assess the Safety of GRF6021 Infusions in Subjects With Parkinson's Disease and Cognitive Impairment

  NCT03713957

  Condition:   Parkinson Disease
  Interventions:   Drug: GRF6021;   Other: Placebo
  Sponsors:   Alkahest, Inc.;   Michael J. Fox Foundation for Parkinson's Research
  Recruiting
• Study to Assess the Long Term Safety and Tolerability of ACT-541468 in Adult and Elderly Subjects Suffering From Difficulties to Sleep

  NCT03679884

  Condition:   Insomnia Disorder
  Interventions:   Drug: ACT-541468 10 mg;   Drug: ACT-541468 25 mg;   Drug: ACT-541468 50 mg;   Drug: Placebo
  Sponsor:   Idorsia Pharmaceuticals Ltd.
  Recruiting
• Single and Multiple Ascending Doses of MEDI6570 in Subjects With Type 2 Diabetes Mellitus

  NCT03654313

  Conditions:   Atherosclerosis;   Cardiovascular Disease
  Interventions:   Biological: MEDI6570;   Biological: Placebo;   Biological: Part B Placebo
  Sponsor:   MedImmune LLC
  Recruiting
• Long-term Safety, Tolerability and Effectiveness Study of Ofatumumab in Patients With Relapsing MS

  NCT03650114

  Condition:   Relapsing Multiple Sclerosis
  Interventions:   Biological: Ofatumumab;   Biological: Tetanus toxoid (TT) containing vaccine (Td, Tdap);   Biological: 13-valent pneumococcal conjugate vaccine (13-PCV);   Biological: 23-valent pneumococcal polysaccharide vaccine (23-PPV);   Biological: Seasonal Quadrivalent influenza vaccine;   Biological: Keyhole limpet hemocyanin (KLH) neo-antigen
  Sponsor:   Novartis Pharmaceuticals
  Recruiting
• REPRISE IV: LOTUS Edge Valve System in Intermediate Surgical Risk Subjects

  NCT03618095

  Condition:   Aortic Valve Stenosis
  Intervention:   Device: LOTUS Edge Valve System
  Sponsor:   Boston Scientific Corporation
  Recruiting
• Safety and Efficacy of KPI-121 in Subjects With DED

  NCT03616899

  Condition:   Kerato Conjunctivitis Sicca
  Interventions:   Drug: KPI-121 Ophthalmic Suspension;   Drug: Vehicle
  Sponsor:   Kala Pharmaceuticals, Inc.
  Recruiting
• Long-term Extension Trial in Subjects With Atopic Dermatitis Who Participated in Previous Tralokinumab Trials - ECZTEND

  NCT03587805

  Condition:   Atopic Dermatitis
  Intervention:   Drug: Tralokinumab
  Sponsor:   LEO Pharma
  Recruiting
• ATOP TRIAL: T-DM1 in HER2 Positive Breast Cancer

  NCT03587740

  Condition:   Breast Cancer
  Intervention:   Drug: T-DM1
  Sponsors:   Dana-Farber Cancer Institute;   Susan G. Komen Breast Cancer Foundation;   Gateway for Cancer Research
  Recruiting
• PSD502 in Subjects With Premature Ejaculation

  NCT03578783

  Condition:   Premature Ejaculation
  Interventions:   Drug: Placebo;   Drug: PSD502
  Sponsor:   Plethora Solutions Ltd
  Recruiting
• Study to Assess the Efficacy and Safety of ACT-541468 in Adult and Elderly Subjects Suffering From Difficulties to Sleep

  NCT03575104

  Condition:   Insomnia Disorder
  Interventions:   Drug: ACT-541468;   Other: Placebo
  Sponsor:   Idorsia Pharmaceuticals Ltd.
  Recruiting
• A Cariprazine Study in the Prevention of Relapse in Bipolar I Disorder Patients Whose Current Episode is Manic or Depressive, With or Without Mixed Features

  NCT03573297

  Conditions:   Bipolar I Disorder;   Mania;   Depression
  Interventions:   Drug: Cariprazine;   Drug: Placebo
  Sponsor:   Forest Laboratories
  Recruiting
• A Study to Evaluate the Efficacy and Safety of TAK-906 in Adult Participants With Symptomatic Idiopathic or Diabetic Gastroparesis

  NCT03544229

  Conditions:   Diabetic Gastroparesis;   Idiopathic Gastroparesis
  Interventions:   Drug: TAK-906 Maleate;   Drug: TAK-906 Maleate Placebo
  Sponsor:   Millennium Pharmaceuticals, Inc.
  Recruiting
• A Multicenter Study of the Efficacy and Safety of JZP-258 in the Treatment of Idiopathic Hypersomnia (IH) With an Open-label Safety Extension

  NCT03533114

  Condition:   Idiopathic Hypersomnia
  Interventions:   Drug: JZP-258;   Drug: Placebo Oral Solution
  Sponsor:   Jazz Pharmaceuticals
  Recruiting
• Effect of Sotagliflozin on Cardiovascular Events in Patients With Type 2 Diabetes Post Worsening Heart Failure (SOLOIST-WHF Trial)

  NCT03521934

  Condition:   Heart Failure-Type 2 Diabetes Mellitus
  Interventions:   Drug: Sotagliflozin (SAR439954);   Drug: Placebo
  Sponsor:   Sanofi
  Recruiting
• A Study to Evaluate the Effect of Testosterone Replacement Therapy (TRT) on the Incidence of Major Adverse Cardiovascular Events (MACE) and Efficacy Measures in Hypogonadal Men

  NCT03518034

  Conditions:   Hypogonadism;   Cardiovascular Diseases
  Interventions:   Drug: Testosterone;   Drug: Placebo
  Sponsors:   AbbVie;   Acerus Pharmaceuticals Corporation;   Allergan Sales, LLC;   Endo Pharmaceuticals;   Upsher-Smith Laboratories
  Recruiting
• ECG Belt for CRT Response

  NCT03504020

  Condition:   Heart Failure
  Intervention:   Device: ECG Belt Research System
  Sponsor:   Medtronic Cardiac Rhythm and Heart Failure
  Recruiting
• Reducing Lung CongestIon Symptoms in Advanced Heart Failure

  NCT03499236

  Condition:   Heart Failure
  Interventions:   Device: V-Wave Interatrial Shunt;   Other: Control
  Sponsor:   V-Wave Ltd
  Recruiting
• To Assess the Patients' Ability to Self-Administer Fasinumab

  NCT03491904

  Conditions:   Osteoarthritis, Knee;   Osteoarthritis, Hip
  Interventions:   Drug: Fasinumab AI;   Drug: Fasinumab PFS
  Sponsors:   Regeneron Pharmaceuticals;   Teva Pharmaceutical Industries, Ltd.
  Recruiting
• FLExAbility Sensor Enabled Substrate Targeted Ablation for the Reduction of VT Study

  NCT03490201

  Condition:   Ventricular Tachycardia
  Interventions:   Device: Market Approved RF Ablation System;   Device: FlexAbility SE Ablation Catheter
  Sponsor:   Abbott Medical Devices
  Recruiting
• Benefits of µCor in Ambulatory Decompensated Heart Failure

  NCT03476187

  Condition:   Heart Failure
  Intervention:   Device: µCor
  Sponsor:   Zoll Medical Corporation
  Recruiting
• Study to Investigate CSL112 in Subjects With Acute Coronary Syndrome

  NCT03473223

  Condition:   Acute Coronary Syndrome
  Interventions:   Biological: Apolipoprotein A-I [human] (apoA-I);   Other: Placebo
  Sponsor:   CSL Behring
  Recruiting
• Study To Evaluate the Efficacy, Safety and Tolerability of E2027 in Participants With Dementia With Lewy Bodies

  NCT03467152

  Condition:   Dementia With Lewy Bodies
  Interventions:   Drug: E2027;   Drug: Placebo
  Sponsor:   Eisai Inc.
  Recruiting
• Safety and Efficacy of Adalimumab Versus Ustekinumab for One Year

  NCT03464136

  Condition:   Crohn Disease
  Interventions:   Biological: Placebo for Ustekinumab;   Biological: Placebo for Adalimumab;   Biological: Ustekinumab (6 mg/kg);   Biological: Ustekinumab (90 mg);   Biological: Adalimumab (40 mg)
  Sponsor:   Janssen Scientific Affairs, LLC
  Recruiting
• Efficacy and Safety Study of Gantenerumab in Participants With Early Alzheimer's Disease (AD)

  NCT03444870

  Condition:   Alzheimer Disease
  Interventions:   Drug: Gantenerumab;   Drug: Placebo
  Sponsor:   Hoffmann-La Roche
  Recruiting
• Safety and Efficacy Study of Gantenerumab in Participants With Early Alzheimer's Disease (AD)

  NCT03443973

  Condition:   Alzheimer's Disease
  Interventions:   Drug: Gantenerumab;   Drug: Placebo
  Sponsor:   Hoffmann-La Roche
  Recruiting
• Oral Sulopenem-etzadroxil/Probenecid Versus Ciprofloxacin for Uncomplicated Urinary Tract Infection in Adult Women

  NCT03354598

  Condition:   Uncomplicated Urinary Tract Infections
  Interventions:   Drug: Sulopenem-Etzadroxil/Probenecid;   Drug: Ciprofloxacin
  Sponsor:   Iterum Therapeutics, International Limited
  Recruiting
• A Study of the Efficacy and Safety of Upadacitnib (ABT-494) in Subjects With Moderately to Severely Active Crohn's Disease Who Have Inadequately Responded to or Are Intolerant to Conventional and/or Biologic Therapies

  NCT03345849

  Condition:   Crohn's Disease
  Interventions:   Drug: Upadacitinib;   Drug: Placebo for Upadacitinib
  Sponsor:   AbbVie
  Recruiting
• A Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Subjects With Moderately to Severely Active Crohn's Disease Who Have Inadequately Responded to or Are Intolerant to Biologic Therapy

  NCT03345836

  Condition:   Crohn's Disease
  Interventions:   Other: Matching placebo for upadacitinib;   Drug: upadacitinib
  Sponsor:   AbbVie
  Recruiting
• Safety and Tolerability Study Of PF-06835375 In Subjects With Seropositive Systemic Lupus Erythematosus Or Rheumatoid Arthritis

  NCT03334851

  Conditions:   Systemic Lupus Erythematosus;   Rheumatoid Arthritis
  Interventions:   Drug: PF-06835375;   Drug: Placebo
  Sponsor:   Pfizer
  Recruiting
• An Investigational Study to Evaluate BMS-986165 in Patients With Systemic Lupus Erythematosus

  NCT03252587

  Condition:   Systemic Lupus Erythematosus
  Interventions:   Drug: BMS-986165;   Other: Placebo
  Sponsor:   Bristol-Myers Squibb
  Recruiting
• Electronic Patient Reporting of Symptoms During Cancer Treatment

  NCT03249090

  Conditions:   Advanced Cancer;   Metastatic Cancer
  Interventions:   Other: Patient Self-Reporting of Symptoms;   Other: Usual Care Delivery
  Sponsors:   Alliance Foundation Trials, LLC.;   Patient-Centered Outcomes Research Institute;   University of North Carolina;   Mayo Clinic;   American Society of Clinical Oncology;   American Cancer Society, Inc.;   Dana-Farber Cancer Institute
  Recruiting
• Pembrolizumab in Treating Patients With Locally Advanced Bladder Cancer

  NCT03244384

  Conditions:   Stage II Bladder Urothelial Carcinoma AJCC v6 and v7;   Stage III Bladder Urothelial Carcinoma AJCC v6 and v7
  Interventions:   Other: Clinical Observation;   Other: Laboratory Biomarker Analysis;   Biological: Pembrolizumab;   Other: Pharmacological Study;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Nivolumab After Combined Modality Therapy in Treating Patients With High Risk Stage II-IIIB Anal Cancer

  NCT03233711

  Conditions:   Anal Basaloid Carcinoma;   Anal Canal Cloacogenic Carcinoma;   Anal Margin Squamous Cell Carcinoma;   Stage IIB Anal Cancer AJCC v8;   Stage IIIA Anal Cancer AJCC v8;   Stage IIIB Anal Cancer AJCC v8;   Stage IIIC Anal Cancer AJCC v8
  Interventions:   Biological: Nivolumab;   Other: Patient Observation
  Sponsors:   National Cancer Institute (NCI);   Canadian Cancer Trials Group
  Recruiting
• Stellarex DCB Versus Standard Balloon Angioplasty for Treatment of Below-The-Knee (BTK) Arteries

  NCT03175744

  Condition:   Critical Limb Ischemia
  Interventions:   Device: Stellarex DCB;   Device: PTA Catheter
  Sponsor:   Spectranetics Corporation
  Recruiting
• An Effectiveness-Implementation Trial of SPIRIT in ESRD

  NCT03138564

  Condition:   End Stage Renal Disease
  Interventions:   Behavioral: SPIRIT;   Behavioral: Comparison Condition
  Sponsors:   Emory University;   National Institute of Nursing Research (NINR)
  Recruiting
• Study to Assess Outcomes in Women Undergoing Either Hysteroscopic Sterilization (Essure®) or Laparoscopic Tubal Sterilization

  NCT03127722

  Condition:   Contraception
  Interventions:   Procedure: Blood draw;   Device: ESSURE (BAY1454032);   Procedure: Laparoscopic tubal sterilization
  Sponsor:   Bayer
  Recruiting
• Evaluation of Treatment Strategies for Severe CaLcIfic Coronary Arteries: Orbital Atherectomy vs. Conventional Angioplasty Technique Prior to Implantation of Drug-Eluting StEnts: The ECLIPSE Trial

  NCT03108456

  Conditions:   Coronary Artery Disease;   Ischemic Heart Disease;   Non ST Segment Elevation Myocardial Infarction
  Interventions:   Device: Orbital Atherectomy;   Device: Balloon
  Sponsors:   Cardiovascular Systems Inc;   Cardiovascular Research Foundation, New York
  Recruiting
• A Study of the Efficacy and Safety of Risankizumab in Subjects With Crohn's Disease Who Responded to Induction Treatment in M16-006 or M15-991; or Completed M15-989

  NCT03105102

  Condition:   Crohn's Disease
  Interventions:   Drug: placebo for risankizumab SC;   Drug: risankizumab IV;   Drug: placebo for risankizumab IV;   Drug: risankizumab SC
  Sponsor:   AbbVie
  Recruiting
• Efficacy and Safety of Filgotinib in the Treatment of Perianal Fistulizing Crohn's Disease

  NCT03077412

  Condition:   Fistulizing Crohn's Disease
  Interventions:   Drug: Filgotinib;   Drug: Placebo to match filgotinib
  Sponsors:   Gilead Sciences;   Galapagos NV
  Recruiting
• MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study

  NCT03072927

  Condition:   Lumbar Spinal Stenosis
  Intervention:   Device: MILD
  Sponsor:   Vertos Medical, Inc.
  Recruiting
• Pemafibrate to Reduce Cardiovascular OutcoMes by Reducing Triglycerides IN patiENts With diabeTes (PROMINENT)

  NCT03071692

  Conditions:   Type2 Diabetes;   Dyslipidemia
  Interventions:   Drug: K-877;   Drug: Placebo
  Sponsors:   Kowa Research Institute, Inc.;   Brigham and Women's Hospital
  Recruiting
• Profiling Biospecimens From Cancer Patients to Screen for Molecular Alterations Related to Treatment Selection

  NCT03061305

  Conditions:   Cancer;   Adult Solid Tumor;   Lymphoma
  Intervention:  
  Sponsor:   Strata Oncology
  Recruiting
• Efficacy and Safety of Filgotinib in the Treatment of Small Bowel Crohn's Disease (SBCD)

  NCT03046056

  Condition:   Small Bowel Crohn's Disease
  Interventions:   Drug: Filgotinib;   Drug: Placebo to match filgotinib
  Sponsors:   Gilead Sciences;   Galapagos NV
  Recruiting
• AURORA: Phase 3 Study for the Efficacy and Safety of CVC for the Treatment of Liver Fibrosis in Adults With NASH

  NCT03028740

  Condition:   Nonalcoholic Steatohepatitis
  Interventions:   Drug: Cenicriviroc;   Drug: Placebo
  Sponsor:   Tobira Therapeutics, Inc.
  Recruiting
• QUILT-3.032: A Multicenter Clinical Trial of Intravesical Bacillus Calmette-Guerin (BCG) in Combination With ALT-803 in Patients With BCG Unresponsive High Grade Non-Muscle Invasive Bladder Cancer

  NCT03022825

  Condition:   Bladder Cancer
  Interventions:   Drug: ALT-803;   Drug: BCG
  Sponsor:   Altor BioScience
  Recruiting
• Comparison of Operative to Monitoring and Endocrine Therapy (COMET) Trial For Low Risk DCIS

  NCT02926911

  Conditions:   DCIS;   Ductal Carcinoma in Situ
  Interventions:   Other: Guideline Concordant Care;   Other: Active Surveillance
  Sponsors:   Alliance Foundation Trials, LLC.;   Patient-Centered Outcomes Research Institute;   Duke University;   Dana-Farber Cancer Institute;   M.D. Anderson Cancer Center;   New York University;   Washington University School of Medicine
  Recruiting
• Filgotinib in the Induction and Maintenance of Remission in Adults With Moderately to Severely Active Crohn's Disease

  NCT02914561

  Condition:   Crohn's Disease
  Interventions:   Drug: Filgotinib;   Drug: Placebo to match filgotinib
  Sponsors:   Gilead Sciences;   Galapagos NV
  Recruiting
• Anemia Studies in Chronic Kidney Disease: Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor Daprodustat-Non-Dialysis (ASCEND-ND)

  NCT02876835

  Condition:   Anaemia
  Interventions:   Drug: Daprodustat;   Drug: Darbepoetin alfa;   Drug: Placebo;   Drug: Iron Therapy
  Sponsor:   GlaxoSmithKline
  Recruiting
• Study to Assess the Efficacy and Safety of Ublituximab + TGR-1202 With or Without Bendamustine and TGR-1202 Alone in Patients With Previously Treated Non-Hodgkins Lymphoma

  NCT02793583

  Conditions:   Diffuse Large B-Cell Lymphoma;   Follicular Lymphoma;   Marginal Zone Lymphoma;   Mantle Cell Lymphoma
  Interventions:   Drug: TGR-1202 + Ublituximab;   Drug: TGR-1202;   Drug: TGR-1202 + Ublituximab + Bendamustine
  Sponsor:   TG Therapeutics, Inc.
  Recruiting
• The PARTNER 3 - Trial - The Safety and Effectiveness of the SAPIEN 3 Transcatheter Heart Valve in Low Risk Patients With Aortic Stenosis

  NCT02675114

  Condition:   Aortic Stenosis
  Interventions:   Procedure: Surgical aortic valve replacement (SAVR);   Device: Transcatheter Aortic Valve Replacement (TAVR)
  Sponsor:   Edwards Lifesciences
  Recruiting
• Baroreflex Activation Therapy for Heart Failure

  NCT02627196

  Condition:   Heart Failure
  Interventions:   Device: BAROSTIM NEO® System;   Drug: Medical Management
  Sponsor:   CVRx, Inc.
  Recruiting
• An Open-Label Phase 3 Study to Examine the Long-Term Safety, Tolerability and Efficacy of APL-130277 for the Acute Treatment of "OFF" Episodes in Patients With Parkinson's Disease

  NCT02542696

  Condition:   Parkinson Disease
  Intervention:   Drug: APL-130277
  Sponsor:   Sunovion
  Recruiting
• Osimertinib and Navitoclax in Treating Patients With EGFR-Positive Previously Treated Advanced or Metastatic Non-small Cell Lung Cancer

  NCT02520778

  Conditions:   Advanced Lung Non-Squamous Non-Small Cell Carcinoma;   Metastatic Lung Non-Squamous Non-Small Cell Carcinoma;   Stage III Lung Non-Small Cell Cancer AJCC v7;   Stage IIIA Lung Non-Small Cell Cancer AJCC v7;   Stage IIIB Lung Non-Small Cell Cancer AJCC v7;   Stage IV Lung Non-Small Cell Cancer AJCC v7
  Interventions:   Drug: Navitoclax;   Drug: Osimertinib
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Cediranib Maleate and Olaparib or Standard Chemotherapy in Treating Patients With Recurrent Platinum-Resistant or -Refractory Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

  NCT02502266

  Conditions:   Fallopian Tube Clear Cell Adenocarcinoma;   Fallopian Tube Endometrioid Adenocarcinoma;   Fallopian Tube Serous Adenocarcinoma;   Fallopian Tube Transitional Cell Carcinoma;   Fallopian Tube Undifferentiated Carcinoma;   Ovarian Clear Cell Adenocarcinoma;   Ovarian Endometrioid Adenocarcinoma;   Ovarian Seromucinous Carcinoma;   Ovarian Serous Adenocarcinoma;   Ovarian Transitional Cell Carcinoma;   Ovarian Undifferentiated Carcinoma;   Primary Peritoneal Serous Adenocarcinoma;   Recurrent Fallopian Tube Carcinoma;   Recurrent Ovarian Carcinoma;   Recurrent Primary Peritoneal Carcinoma
  Interventions:   Drug: Cediranib;   Drug: Cediranib Maleate;   Drug: Olaparib;   Drug: Paclitaxel;   Drug: Pegylated Liposomal Doxorubicin Hydrochloride;   Other: Questionnaire Administration;   Drug: Topotecan;   Drug: Topotecan Hydrochloride
  Sponsors:   National Cancer Institute (NCI);   NRG Oncology
  Recruiting
• Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

  NCT02465060

  Conditions:   Advanced Malignant Solid Neoplasm;   Bladder Carcinoma;   Breast Carcinoma;   Cervical Carcinoma;   Colon Carcinoma;   Colorectal Carcinoma;   Endometrial Carcinoma;   Esophageal Carcinoma;   Gastric Carcinoma;   Glioma;   Head and Neck Carcinoma;   Kidney Carcinoma;   Liver and Intrahepatic Bile Duct Carcinoma;   Lung Carcinoma;   Lymphoma;   Malignant Uterine Neoplasm;   Melanoma;   Ovarian Carcinoma;   Pancreatic Carcinoma;   Plasma Cell Myeloma;   Prostate Carcinoma;   Rectal Carcinoma;   Recurrent Bladder Carcinoma;   Recurrent Breast Carcinoma;   Recurrent Cervical Carcinoma;   Recurrent Colon Carcinoma;   Recurrent Colorectal Carcinoma;   Recurrent Esophageal Carcinoma;   Recurrent Gastric Carcinoma;   Recurrent Glioma;   Recurrent Head and Neck Carcinoma;   Recurrent Liver Carcinoma;   Recurrent Lung Carcinoma;   Recurrent Lymphoma;   Recurrent Malignant Solid Neoplasm;   Recurrent Melanoma;   Recurrent Ovarian Carcinoma;   Recurrent Pancreatic Carcinoma;   Recurrent Plasma Cell Myeloma;   Recurrent Prostate Carcinoma;   Recurrent Rectal Carcinoma;   Recurrent Skin Carcinoma;   Recurrent Thyroid Gland Carcinoma;   Recurrent Uterine Corpus Carcinoma;   Refractory Lymphoma;   Refractory Malignant Solid Neoplasm;   Refractory Plasma Cell Myeloma;   Skin Carcinoma;   Thyroid Gland Carcinoma;   Uterine Corpus Cancer
  Interventions:   Drug: Adavosertib;   Drug: Afatinib;   Drug: Afatinib Dimaleate;   Drug: Binimetinib;   Drug: Capivasertib;   Drug: Copanlisib;   Drug: Copanlisib Hydrochloride;   Drug: Crizotinib;   Other: Cytology Specimen Collection Procedure;   Drug: Dabrafenib;   Drug: Dabrafenib Mesylate;   Drug: Dasatinib;   Drug: Defactinib;   Drug: Defactinib Hydrochloride;   Drug: Erdafitinib;   Drug: FGFR Inhibitor AZD4547;   Drug: Ipatasertib;   Other: Laboratory Biomarker Analysis;   Drug: Larotrectinib;   Drug: Larotrectinib Sulfate;   Biological: Nivolumab;   Drug: Osimertinib;   Drug: Palbociclib;   Biological: Pertuzumab;   Drug: PI3K-beta Inhibitor GSK2636771;   Drug: Sapanisertib;   Drug: Sunitinib Malate;   Drug: Taselisib;   Drug: Trametinib;   Biological: Trastuzumab;   Biological: Trastuzumab Emtansine;   Drug: Ulixertinib;   Drug: Vismodegib
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• A Study in Patients With Acute Major Bleeding to Evaluate the Ability of Andexanet Alfa to Reverse the Anticoagulation Effect of Direct and Indirect Oral Anticoagulants (Extension Study)

  NCT02329327

  Condition:   Bleeding
  Intervention:   Biological: Andexanet
  Sponsors:   Portola Pharmaceuticals;   Population Health Research Institute
  Recruiting
• Genetic Testing in Screening Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been or Will Be Removed by Surgery (The ALCHEMIST Screening Trial)

  NCT02194738

  Conditions:   Lung Adenocarcinoma;   Lung Large Cell Carcinoma;   Resectable Lung Non-Small Cell Carcinoma;   Stage IB Lung Non-Small Cell Carcinoma AJCC v7;   Stage IB Lung Squamous Cell Carcinoma AJCC v7;   Stage II Lung Non-Small Cell Cancer AJCC v7;   Stage II Lung Squamous Cell Carcinoma AJCC v7;   Stage IIA Lung Non-Small Cell Carcinoma AJCC v7;   Stage IIA Lung Squamous Cell Carcinoma AJCC v7;   Stage IIB Lung Non-Small Cell Carcinoma AJCC v7;   Stage IIB Lung Squamous Cell Carcinoma AJCC v7;   Stage IIIA Lung Non-Small Cell Cancer AJCC v7;   Stage IIIA Lung Squamous Cell Carcinoma AJCC v7
  Interventions:   Other: Clinical Observation;   Drug: Crizotinib;   Other: Cytology Specimen Collection Procedure;   Drug: Erlotinib;   Drug: Erlotinib Hydrochloride;   Biological: Nivolumab;   Other: Placebo
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Erlotinib Hydrochloride in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been Completely Removed by Surgery (An ALCHEMIST Treatment Trial)

  NCT02193282

  Conditions:   EGFR Exon 19 Deletion Mutation;   EGFR NP_005219.2:p.L858R;   Stage IB Lung Non-Small Cell Carcinoma AJCC v7;   Stage II Lung Non-Small Cell Cancer AJCC v7;   Stage IIA Lung Non-Small Cell Carcinoma AJCC v7;   Stage IIB Lung Non-Small Cell Carcinoma AJCC v7;   Stage IIIA Lung Non-Small Cell Cancer AJCC v7
  Interventions:   Other: Clinical Observation;   Drug: Erlotinib;   Drug: Erlotinib Hydrochloride;   Other: Laboratory Biomarker Analysis;   Other: Placebo
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• A Study of Intravesical BCG in Combination With ALT-803 in Patients With Non-Muscle Invasive Bladder Cancer

  NCT02138734

  Condition:   Non-muscle Invasive Bladder Cancer
  Interventions:   Biological: BCG+ALT-803;   Biological: BCG
  Sponsor:   Altor BioScience
  Recruiting
• Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

  NCT02089217

  Condition:   Carotid Stenosis
  Interventions:   Procedure: Carotid endarterectomy (CEA);   Device: Carotid Stenting (CAS);   Other: Intensive Medical Management - no CEA;   Other: Intensive Medical Management - no CAS
  Sponsors:   Thomas G. Brott, M.D.;   National Institute of Neurological Disorders and Stroke (NINDS)
  Recruiting
• Best Endovascular vs. Best Surgical Therapy in Patients With Critical Limb Ischemia

  NCT02060630

  Condition:   Critical Limb Ischemia
  Interventions:   Procedure: Open surgical revascularization;   Device: Endovascular revascularization
  Sponsors:   New England Research Institutes;   Brigham and Women's Hospital;   Massachusetts General Hospital;   Boston Medical Center;   National Heart, Lung, and Blood Institute (NHLBI)
  Recruiting
• Dimethyl Fumarate (DMF) Observational Study

  NCT02047097

  Condition:   Multiple Sclerosis
  Intervention:   Drug: dimethyl fumarate
  Sponsor:   Biogen
  Recruiting
• Lenalidomide Plus Rituximab Followed by Lenalidomide Versus Rituximab Maintenance for Relapsed/Refractory Follicular, Marginal Zone or Mantle Cell Lymphoma.

  NCT01996865

  Condition:   Lymphoma, Non-Hodgkin
  Interventions:   Drug: Lenalidomide;   Drug: Rituximab
  Sponsor:   Celgene
  Recruiting
• Apixaban for the Reduction of Thrombo-Embolism in Patients With Device-Detected Sub-Clinical Atrial Fibrillation

  NCT01938248

  Conditions:   Atrial Fibrillation;   Stroke
  Interventions:   Drug: Apixaban;   Drug: aspirin
  Sponsors:   Population Health Research Institute;   Bristol-Myers Squibb;   Pfizer;   Medtronic;   Canadian Institutes of Health Research (CIHR);   Hamilton Health Sciences Foundation
  Recruiting
• Safety and Effectiveness of Belimumab in Systemic Lupus Erythematosus Registry

  NCT01729455

  Condition:   Systemic Lupus Erythematosus
  Interventions:   Biological: BENLYSTA;   Other: SLE treatment
  Sponsors:   Human Genome Sciences Inc., a GSK Company;   GlaxoSmithKline
  Recruiting
• Radiation Therapy Regimens in Treating Patients With Limited-Stage Small Cell Lung Cancer Receiving Cisplatin and Etoposide

  NCT00632853

  Condition:   Lung Cancer
  Interventions:   Radiation: Standard Radiation Dose Therapy;   Drug: cisplatin;   Drug: etoposide;   Radiation: High Radiation Dose Therapy;   Drug: carboplatin
  Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI)
  Recruiting
• Psoriasis Longitudinal Assessment and Registry (PSOLAR)

  NCT00508547

  Conditions:   Psoriasis;   Arthritis, Psoriatic
  Interventions:   Biological: Ustekinumab;   Biological: Biological therapies other than infliximab, ustekinumab and guselkumab;   Drug: Conventional systemic agents;   Biological: Infliximab;   Biological: Guselkumab
  Sponsor:   Janssen Scientific Affairs, LLC
  Recruiting
• Setmelanotide (RM-493), Melanocortin-4 Receptor (MC4R) Agonist, in Bardet-Biedl Syndrome (BBS) and Alström Syndrome (AS) Patients With Moderate to Severe Obesity

  NCT03746522

  Conditions:   Bardet Biedl Syndrome (BBS);   Alström Syndrome (AS)
  Interventions:   Drug: Setmelanotide;   Drug: Placebos
  Sponsor:   Rhythm Pharmaceuticals, Inc.
  Recruiting
• Phase 3 Study of Oral Ibrexafungerp (SCY-078) Vs. Placebo in Subjects With Recurrent Vulvovaginal Candidiasis (VVC)

  NCT04029116

  Condition:   Recurrent Vulvovaginal Candidiasis
  Interventions:   Drug: Fluconazole Tablet;   Drug: IBREXAFUNGERP;   Drug: Placebo oral tablet
  Sponsor:   Scynexis, Inc.
  Recruiting
• Evaluation of the Efficacy and Safety of Lebrikizumab in Moderate to Severe Atopic Dermatitis

  NCT04146363

  Condition:   Atopic Dermatitis
  Interventions:   Biological: Lebrikizumab;   Other: Placebo
  Sponsor:   Dermira, Inc.
  Recruiting
• Topical Ruxolitinib Evaluation in Vitiligo Study 1 (TRuE-V1)

  NCT04052425

  Condition:   Non-segmental Vitiligo
  Interventions:   Drug: Ruxolitinib cream;   Drug: Vehicle
  Sponsor:   Incyte Corporation
  Recruiting
• A Study of Crisaborole Ointment 2%; Crisaborole Vehicle; TCS and TCI in Subjects Aged ≥ 2 Years, With Mild-moderate AD

  NCT03539601

  Condition:   Atopic Dermatitis
  Interventions:   Drug: Crisaborole ointment, 2%;   Drug: Hydrocortisone butyrate cream, 0.1%;   Drug: Pimecrolimus cream, 1%;   Drug: Crisaborole Vehicle
  Sponsor:   Pfizer
  Recruiting
• Safety, Tolerability, and Immunogenicity of V114 in Healthy Infants (V114-029)

  NCT03893448

  Conditions:   Pneumococcal Infections;   Pneumococcal Vaccines
  Interventions:   Biological: V114;   Biological: Prevnar 13™;   Biological: RotaTeq™;   Biological: Pentacel™;   Biological: RECOMBIVAX HB™;   Biological: VAQTA™;   Biological: M-M-R™;   Biological: VARIVAX™;   Biological: HIBERIX™
  Sponsor:   Merck Sharp & Dohme Corp.
  Recruiting
• Study to Investigate Efficacy and Safety of PF-04965842 in Subjects Aged 12 Years and Over With Moderate to Severe Atopic Dermatitis With the Option of Rescue Treatment in Flaring Subjects

  NCT03627767

  Conditions:   Dermatitis;   Dermatitis, Atopic;   Eczema;   Skin Diseases;   Skin Diseases, Genetic;   Genetic Diseases, Inborn;   Skin Diseases, Eczematous;   Hypersensitivity;   Hypersensitivity, Immediate;   Immune System Diseases
  Interventions:   Drug: PF-04965842 100 mg;   Drug: PF-04965842 200 mg;   Drug: Placebo
  Sponsor:   Pfizer
  Recruiting
• Disrupt CAD III With the Shockwave Coronary IVL System

  NCT03595176

  Conditions:   Coronary Artery Disease;   Myocardial Infarction
  Intervention:   Device: Lithotripsy
  Sponsor:   Shockwave Medical, Inc.
  Recruiting
• Study to Evaluate Efficacy and Safety of PF-04965842 With or Without Topical Medications in Subjects Aged 12 Years and Older With Moderate to Severe Atopic Dermatitis

  NCT03422822

  Condition:   Dermatitis, Atopic
  Interventions:   Drug: PF-04965842 100 mg;   Drug: PF-04965842 200 mg;   Drug: Placebo
  Sponsor:   Pfizer
  Recruiting
• A Study of the Efficacy and Safety of Risankizumab in Subjects With Moderately to Severely Active Crohn's Disease

  NCT03105128

  Condition:   Crohn's Disease
  Interventions:   Drug: placebo for risankizumab;   Drug: risankizumab IV;   Drug: risankizumab SC
  Sponsor:   AbbVie
  Recruiting
• A Study to Assess the Efficacy and Safety of Risankizumab in Subjects With Moderately to Severely Active Crohn's Disease Who Failed Prior Biologic Treatment

  NCT03104413

  Condition:   Crohn's Disease
  Interventions:   Drug: placebo for risankizumab IV;   Drug: risankizumab SC;   Drug: risankizumab IV
  Sponsor:   AbbVie
  Recruiting
• Setmelanotide Phase 2 Treatment Trial in Patients With Rare Genetic Disorders of Obesity

  NCT03013543

  Conditions:   Pro-opiomelanocortin (POMC) Deficiency Obesity (Heterozygous or Epigenetic);   Leptin Receptor Deficiency Obesity;   Bardet-Biedl Syndrome;   Alstrom Syndrome;   Smith-Magenis Syndrome
  Intervention:   Drug: Setmelanotide
  Sponsor:   Rhythm Pharmaceuticals, Inc.
  Recruiting
• Chronic Hypertension and Pregnancy (CHAP) Project

  NCT02299414

  Condition:   Hypertension
  Interventions:   Drug: Anti-hypertensive therapy;   Other: No anti-hypertensive therapy (unless BP is severe)
  Sponsors:   University of Alabama at Birmingham;   Columbia University;   Drexel University College of Medicine;   Rutgers, The State University of New Jersey;   Lehigh Valley Hospital;   Saint Peters University Hospital;   Christiana Care Health Services;   Washington University School of Medicine;   Duke University;   University of Texas Southwestern Medical Center;   The University of Texas Health Science Center, Houston;   Stanford University;   University of Pennsylvania;   The University of Texas Medical Branch, Galveston;   University of Utah;   Intermountain Health Care, Inc.;   University of California, San Francisco;   Johns Hopkins University;   University of Pittsburgh;   Ochsner Health System;   University of North Carolina, Chapel Hill;   National Heart, Lung, and Blood Institute (NHLBI);   WakeMed Health and Hospitals;   San Francisco General Hospital;   McKay-Dee Hospital;   Winthrop University Hospital;   New York Hospital Queens;   Latter Day Saints Hospital;   Lyndon B Johnson General Hospital;   Virtua Medical Group;   Bayview Medical Center;   Duke Regional Hospital;   Utah Valley Regional Medical Center;   Northwestern;   Brown (WIHRI);   Baylor College of Medicine;   Case Western/Metro Health;   Ohio State University;   University of Iowa;   University of California, San Diego;   Indiana University;   Unity Point Health-Meriter Hospital WI;   Weill Medical College of Cornell University;   University of Oklahoma;   Medical University of South Carolina;   Beaumont Hospital;   University of Colorado, Denver;   University of Kansas Medical Center;   Denver Health and Hospital Authority;   Gundersen Health System;   Aurora Health Care;   Oregon Health and Science University;   Medical College of Wisconsin;   Temple University;   New Jersey Medical School;   University of South Alabama;   Vanderbilt University;   University of Arkansas;   Miami Valley Hospital;   Emory University;   St. Luke's Hospital and Health Network, Pennsylvania;   Cleveland Clinic Fairview Hospital;   University of Tennessee Health Science Center;   TriHealth Inc.;   Cleveland Clinic Hillcrest Hospital;   Tulane University;   Yale University;   Arrowhead Regional Medical Center;   Geisinger Clinic
  Recruiting
• Safety and Efficacy Study of Lotus Valve for Transcatheter Aortic Valve Replacement

  NCT02202434

  Condition:   Aortic Stenosis
  Interventions:   Device: Lotus Valve System;   Device: CoreValve/Evolut R Transcatheter Aortic Valve Replacement System;   Device: LOTUS Edge Valve System
  Sponsor:   Boston Scientific Corporation
  Recruiting
• Product Surveillance Registry

  NCT01524276

  Conditions:   Cardiac Rhythm Disorders;   Urological Disorders;   Neurological Disorders;   Cardiovascular Disorders;   Digestive Disorders;   Intracranial Aneurysm;   Mechanical Circulatory Support
  Intervention:  
  Sponsor:   Medtronic
  Recruiting
• Safety Study in Patients With Multiple Sclerosis Treated Fingolimod or Other Approved Disease-modifying Therapies

  NCT01442194

  Condition:   Multiple Sclerosis
  Interventions:   Drug: other disease-modifying therapy;   Drug: Fingolimod
  Sponsor:   Novartis Pharmaceuticals
  Recruiting
• Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products

  NCT00271180

  Conditions:   Arrhythmia;   Bradycardia;   Heart Failure;   Sinus Tachycardia
  Intervention:   Device: Device
  Sponsor:   Medtronic
  Recruiting