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• Community-based Intervention Effects on Older Adults' Physical Activity

  NCT03326141

  Conditions:   Exercise;   Physical Activity;   Accidental Fall;   Motivation;   Older Adults
  Interventions:   Behavioral: Otago Exercise Program;   Device: Physical activity monitors (e.g., Fitbit);   Behavioral: Interpersonal Behavior Change Strategies;   Behavioral: Intrapersonal Behavior Change Strategies;   Other: Information about Health and Wellness
  Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   National Institute of Nursing Research (NINR)
  Recruiting
• The ACT Trial: Effects of Combined Aerobic Exercise and Cognitive Training in MCI

  NCT03313895

  Condition:   Mild Cognitive Impairment
  Interventions:   Behavioral: ACT;   Behavioral: Cycling Only;   Behavioral: Cognitive Training Only;   Behavioral: Stretching and Mental Stimulating Activities
  Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   University of Rochester;   Mayo Clinic;   University of St Thomas
  Recruiting
• Post-contracture Release Radiation for Dupuytren's Disease

  NCT04122313

  Conditions:   Dupuytren's Disease;   Dupuytren Contracture;   Dupuytren Disease of Palm and Finger;   Dupuytren Disease of Finger;   Dupuytrens Contracture of Both Hands;   Dupuytren's Disease of Palm of Right Hand;   Dupuytren's Disease of Palm of Left Hand;   Dupuytren Contracture of Right Palm;   Dupuytren Contracture of Left Palm;   Dupuytren's Contracture Left;   Dupuytren's Contracture Right
  Intervention:   Other: Evaluation of Dupuytren's Disease Treatment
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• Traumatic Nightmares Treated by NightWare (To Arouse Not Awaken)

  NCT04040387

  Conditions:   Stress Disorders, Post-Traumatic;   Combat Disorders;   Ptsd;   Nightmare;   Nightmares, REM-Sleep Type;   Nightmare Disorder With Associated Non-Sleep Disorder
  Interventions:   Device: NightWare Therapeutic System;   Device: Sham NightWare
  Sponsors:   NightWare;   Minneapolis Veterans Affairs Medical Center
  Recruiting
• Problem-Solving Therapy for Depressive Symptoms and Quality of Life in Stroke Survivor-Caregiver Dyads

  NCT04035681

  Conditions:   Stroke;   Quality of Life;   Depression
  Interventions:   Behavioral: Problem-Solving Therapy;   Other: Stroke-Related Health Education
  Sponsors:   Allina Health System;   University of Minnesota, MN
  Recruiting
• Repeated Ketamine Infusions for Comorbid PTSD and MDD in Veterans

  NCT04032301

  Conditions:   Post-Traumatic Stress Disorders;   Major Depressive Disorder
  Interventions:   Drug: Ketamine;   Other: Normal Saline
  Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   Minneapolis Veterans Affairs Medical Center
  Recruiting
• FT516 in Subjects With Advanced Hematologic Malignancies

  NCT04023071

  Conditions:   Acute Myelogenous Leukemia;   B-cell Lymphoma
  Interventions:   Drug: FT516;   Drug: Rituximab;   Drug: Obinutuzumab;   Drug: Cyclophosphamide;   Drug: Fludarabine;   Drug: IL-2
  Sponsor:   Fate Therapeutics
  Recruiting
• Cf-DNA Assay During Treatment of Acute Rejection

  NCT04019353

  Conditions:   Kidney Transplant Failure and Rejection;   Kidney Transplant; Complications;   Kidney Transplant Rejection;   Transplant; Complication, Rejection;   Transplant Dysfunction
  Intervention:   Genetic: cf-DNA Collection
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• Allogeneic Skin Grafting

  NCT04015947

  Condition:   GVHD
  Intervention:   Device: CelluTome® Epidermal Harvesting System
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• State-dependent Pathophysiological Oscillations in Parkinson's Disease and Treatment With DBS Using the Medtronic RC+S

  NCT04011449

  Conditions:   Parkinson Disease;   Parkinson
  Intervention:   Device: Medtronic RC+S DBS system
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• Positive Affect Treatment (PAT) to Target Reward Mechanisms in Anorexia Nervosa

  NCT04007900

  Conditions:   Anorexia Nervosa;   Anorexia
  Intervention:   Behavioral: Positive Affect Treatment
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• Pilot Phase for an Acute Evaluation of a Non-Implantable Electrical Continence Device

  NCT04001426

  Condition:   Urinary Bladder, Overactive
  Intervention:   Device: The FemPulse System
  Sponsor:   FemPulse Corporation
  Recruiting
• Hepatic Energy Fluxes in NASH and NAS Patients

  NCT03997422

  Conditions:   NASH - Nonalcoholic Steatohepatitis;   NAS;   Overweight or Obesity;   Weight Loss;   Bariatric Surgery Candidate
  Intervention:   Procedure: Vertical Sleeve Gastrectomy (VSG)
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• Assessment of Complete Pathologic Response After Neoadjuvant Chemotherapy for Breast Cancer

  NCT03981705

  Conditions:   TN ER-/PR-/HER2- Breast Cancer;   Triple Negative Breast Cancer;   HER2-positive Breast Cancer;   ERany/PRany/HER2+ Breast Cancer
  Intervention:   Radiation: Standard Trimodality Breast Imaging
  Sponsor:   Masonic Cancer Center, University of Minnesota
  Recruiting
• Ketamine and Prolonged Exposure in PTSD

  NCT03960658

  Condition:   Post-traumatic Stress Disorder
  Intervention:   Drug: ketamine-enhanced prolonged exposure
  Sponsor:   Minneapolis Veterans Affairs Medical Center
  Recruiting
• Low Sulfur Fecal Transplant for Ulcerative Colitis

  NCT03948919

  Condition:   Ulcerative Colitis
  Interventions:   Drug: Fecal microbiota;   Other: Placebo
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• Androgen Deprivation Therapy (ADT) and Pembrolizumab for Advanced Stage Androgen Receptor-positive Salivary Gland Carcinoma

  NCT03942653

  Condition:   Salivary Gland Carcinoma
  Interventions:   Drug: Goserelin Acetate;   Drug: Pembrolizumab
  Sponsors:   Big Ten Cancer Research Consortium;   Merck Sharp & Dohme Corp.;   TerSera Therapeutics
  Recruiting
• The MOMENTUM Study (Monitoring Maternal Emergency Navigation and Triage on Mfangano

  NCT03942536

  Conditions:   Pregnancy;   Neonatal Care;   Emergency Care
  Intervention:   Other: Focus Group Discussion
  Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   Maseno University
  Recruiting
• The Effect of Vitamin C on Wound Healing In Mandibular Fracture Patients

  NCT03938584

  Conditions:   Vitamin C Deficiency;   Smoking;   Surgery;   Surgery--Complications;   Wound;   Wound Complication;   Wound Infection;   Wound Dehiscence;   Wound of Skin;   Mandible Fracture;   Mandible Open Fracture;   Mandible Closed Fracture;   Mandibular Fractures;   Ascorbic Acid Deficiency;   Oxidative Stress;   Inflammation
  Interventions:   Dietary Supplement: Vitamin C;   Other: Placebo
  Sponsors:   Hennepin Healthcare Research Institute.;   Regions Hospital;   University of Minnesota, MN
  Recruiting
• Training for Health Professionals In Tanzania

  NCT03923582

  Conditions:   Health Knowledge, Attitudes, Practice;   Training
  Intervention:   Behavioral: Health Curriculum Training
  Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   Muhimbili University of Health and Allied Sciences;   Johns Hopkins University
  Recruiting
• The Role of Cytomegalovirus and Inflammation on Patient Symptoms and Outcomes in Ovarian Cancer

  NCT03921658

  Conditions:   Ovarian Cancer;   Fallopian Tube Cancer;   Primary Peritoneal Carcinoma
  Intervention:  
  Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   United States Department of Defense
  Recruiting
• Care to Plan: a Tailored Resource for Family Members of Persons With Dementia

  NCT03901456

  Conditions:   Dementia;   Alzheimer Disease;   Memory Loss
  Interventions:   Behavioral: Care to Plan;   Behavioral: Usual Care
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• Adoptive Transfer of Haploidentical NK Cells and N-803

  NCT03899480

  Conditions:   Hiv;   HIV Infections;   Immune Deficiency
  Intervention:   Biological: Haploidentical Natural Killer (NK) Cells
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• The DEtermining Statin Intolerance FOr Rosuvastatin (DESIFOR) Trial

  NCT03889314

  Conditions:   Cardiovascular Risk Factor;   Cardiovascular Diseases;   Adverse Effect
  Interventions:   Drug: Rosuvastatin 20mg;   Other: Placebo
  Sponsor:   Minneapolis Heart Institute Foundation
  Recruiting
• Advanced Reperfusion Strategies for Refractory Cardiac Arrest

  NCT03880565

  Conditions:   Cardiac Arrest;   Extracorporeal Membrane Oxygenation Complication;   Ventricular Fibrillation;   Pulseless Ventricular Tachycardia;   Out-Of-Hospital Cardiac Arrest
  Interventions:   Device: Early Extracorporeal Membrane Oxygenation (ECMO) Facilitated Resuscitation;   Device: Standard Advanced Cardiac Life Support (ACLS) Resuscitation
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• Laser Assisted Delivery of Minoxidil in Androgenetic Alopecia

  NCT03852992

  Conditions:   Male Pattern Hair Loss;   Androgenetic Alopecia;   Male Pattern Baldness
  Interventions:   Drug: Post-Laser Minoxidil 2%;   Drug: At-Home Minoxidil 5%;   Device: Laser;   Drug: Post-laser 5mg minoxidil;   Drug: Post-laser 10mg minoxidil;   Drug: Post-laser 20mg minoxidil
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• Intra-Portal Alone Versus Intra- and Extra-Portal Transplantation of Pancreatic Islets After Total Pancreatectomy for Chronic Pancreatitis

  NCT03779139

  Conditions:   Chronic Pancreatitis;   Diabetes Mellitus;   Islet Cell Transplantation
  Interventions:   Procedure: Intrahepatic islets and islets in the omental pouch;   Procedure: Intrahepatic islets alone;   Other: Normal Volunteers
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• Scaling and Root Planing (SRP) With and Without Minocycline HCl Microspheres, 1 mg

  NCT03762915

  Conditions:   SRP;   Minocycline HCl Microspheres;   Biomarkers
  Intervention:   Drug: minocycline HCl microspheres
  Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   Bausch Health Companies, INC.
  Recruiting
• Isometric Intervention for Lateral Elbow Tendinopathy

  NCT03756155

  Conditions:   Lateral Elbow Tendinopathy;   Elbow Pain;   Elbows Tendonitis;   Elbow Sprain;   Elbow Injury
  Intervention:   Procedure: isometric intervention
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• Laryngeal Vibration for Spasmodic Dysphonia

  NCT03746509

  Condition:   Spasmodic Dysphonia
  Interventions:   Device: Laryngeal Vibration (Treatment);   Device: Laryngeal Vibration (Comparator)
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• Genotypic Versus Phenotypic Susceptibility Testing of Positive Blood Cultures

  NCT03744728

  Condition:   Bloodstream Infection
  Interventions:   Diagnostic Test: Accelerate PhenoTest™ BC kit;   Diagnostic Test: Standard of Care
  Sponsor:   Accelerate Diagnostics, Inc.
  Recruiting
• Trial of Indole-3-Carbinol and Silibinin

  NCT03687073

  Condition:   Smoking
  Interventions:   Drug: Indole-3-Carbinol;   Drug: Silibinin;   Drug: Silibin
  Sponsor:   Masonic Cancer Center, University of Minnesota
  Recruiting
• A Study of FMT in Patients With AML Allo HSCT in Recipients

  NCT03678493

  Conditions:   Acute Myeloid Leukemia;   Allogeneic Hematopoietic Cell Transplantation
  Interventions:   Biological: Fecal Microbiota Transplant (FMT);   Other: Placebo
  Sponsor:   Masonic Cancer Center, University of Minnesota
  Recruiting
• Spectroscopic Magnetic Resonance Imaging of Glioma

  NCT03677999

  Condition:   Brain Tumor-Glioma
  Intervention:   Diagnostic Test: MEGA-PRESS sequence Magnetic Resonance Spectroscopy
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• Neuromodulation Augmented Cognitive Training to Improve Cognitive Flexibility in Anorexia Nervosa

  NCT03647943

  Conditions:   Active tDCS;   Sham tDCS
  Interventions:   Device: Transcranial direct current stimulation;   Device: Sham transcranial direct current stimulation
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• Evaluation of Diaphragm Movement After an Interscalene Block

  NCT03636542

  Condition:   Phrenic Nerve Paralysis
  Interventions:   Drug: liposomal bupivacaine;   Drug: bupivacaine
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• mGlide RCT: A Clinical Glide Path To Close the Guideline-to-Practice Gap In HTN Management

  NCT03612271

  Condition:   Hypertension
  Intervention:   Behavioral: mGlide
  Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   National Heart, Lung, and Blood Institute (NHLBI)
  Recruiting
• Improving Self-Efficacy, Resolving Inflammaging Allo HSCT Survivors in Personal Training

  NCT03609203

  Condition:   Allogeneic HCT Survivors
  Interventions:   Other: 10 Weeks of Strength Trailing;   Other: Group Nutrition Discussion: week 1, week 5 and week 10
  Sponsor:   Masonic Cancer Center, University of Minnesota
  Recruiting
• Pec Infiltration With Liposomal Bupivacaine for Breast Surgery

  NCT03599635

  Condition:   Acute Pain
  Interventions:   Drug: liposomal bupivacaine;   Drug: Bupivacaine
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• Liposome Bupivacaine Interscalene Total Shoulder

  NCT03587636

  Condition:   Acute Pain
  Interventions:   Drug: liposome bupivacaine;   Drug: Bupivacaine
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• Liposome Bupivacaine in Interscalene Block for Rotator Cuff Repair

  NCT03587584

  Condition:   Acute Pain
  Interventions:   Drug: liposomal bupivacaine;   Drug: Bupivacaine
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• Effect of Constraint-Induced Gaming Therapy in an Acute Care Setting

  NCT03578536

  Condition:   Stroke
  Intervention:   Device: Recovery Rapids
  Sponsor:   VA Office of Research and Development
  Recruiting
• Splenic Embolization for Portal Hypertension

  NCT03532750

  Condition:   Portal Hypertension
  Interventions:   Device: Particle;   Device: Coil
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• Role of CGMS Usage in Predicting Risk for Hypoglycemia

  NCT03481530

  Conditions:   Type 2 Diabetes Mellitus;   Hypoglycemia
  Intervention:   Device: Continuing Glucose Monitor System
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• The Impact of Oxytocin on the Neurobiology of Anorexia Nervosa

  NCT03414112

  Condition:   Anorexia Nervosa
  Intervention:   Biological: Intranasal oxytocin
  Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   Klarman Foundation
  Recruiting
• Post C-Section Pain Control Using EXPAREL

  NCT03377595

  Condition:   Pain, Postoperative
  Intervention:   Drug: Exparel
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• Role of Neurogenic Inflammation and Topical 6% Gabapentin Therapy in Symptomatic Scarring Alopecia

  NCT03346668

  Conditions:   Scarring Alopecia;   Frontal Fibrosing Alopecia;   Lichen Planopilaris;   Central Centrifugal Cicatricial Alopecia;   Central Centrifugal Scarring Alopecia
  Intervention:   Drug: Topical gabapentin
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• Assessing Leg Control in People With Chronic Stroke

  NCT03271463

  Condition:   Chronic Stroke
  Intervention:   Behavioral: Selective Control Assessment of Lower Extremity (SCALE)
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• Safety of Transarterial Chemoembolization (TACE) in the Setting of an Elevated Bilirubin

  NCT03259581

  Conditions:   Hepatocellular Carcinoma;   Bilirubinemia
  Intervention:   Combination Product: Transarterial chemoembolization
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• High-Intensity Aerobic Lifelong Training--AF

  NCT03241433

  Condition:   Atrial Fibrillation
  Interventions:   Other: High intensity interval training;   Other: Moderate intensity continuous training;   Other: No Exercise
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• Applying Neuromodulation to Accelerate Training Effects

  NCT03224559

  Condition:   Cognition
  Intervention:   Device: Transcranial Electrical Stimulation
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• Role of Exogenous and Endogenous Sex Hormones on Tenofovir and Emtricitabine Disposition in Female Genital Tract

  NCT03218085

  Conditions:   HIV/AIDS;   Menopause;   Inflammation Vagina
  Interventions:   Drug: Tenofovir;   Drug: Emtricitabine
  Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   American College of Clinical Pharmacy
  Recruiting
• GTB-3550 (CD16/IL-15/CD33) Tri-Specific Killer Engager (TriKE™) for High Risk Heme Malignancies

  NCT03214666

  Conditions:   High-risk Myelodysplastic Syndromes;   Acute Myelogenous Leukemia;   Systemic Mastocytosis;   Mast Cell Leukemia
  Interventions:   Drug: GTB-3550 TriKE™ Phase I;   Drug: GTB-3550 TriKE™ Phase II
  Sponsor:   GT Biopharma, Inc.
  Recruiting
• Photobiomodulation Therapy and Nerve Density for Patients With Diabetic or Chemotherapy-associated Neuropathy

  NCT03195868

  Conditions:   Neuropathy;   Neuropathy, Diabetic;   Neuropathy Toxic
  Intervention:   Device: Realief Therapy
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• Leg Exercise During ECMO

  NCT03135210

  Condition:   Refractory Respiratory Failure
  Interventions:   Other: Open-Chain Leg Exercise;   Device: Closed-Chain Leg Exercise
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• Circuit-Based Deep Brain Stimulation for Parkinson's Disease; Udall Project 1 Aim 2 and 3

  NCT03079037

  Condition:   Parkinson Disease
  Intervention:   Device: Stimulation
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• IP ALT-803 Followed by SQ ALT-803 for Ovarian Cancer

  NCT03054909

  Conditions:   FIGO Stage III and IV Ovarian Cancer;   FIGO Stage III and IV Fallopian Tube Cancer;   FIGO Stage III Primary Peritoneal Cancer
  Interventions:   Biological: ALT-803 Subcutaneous;   Biological: ALT-803 Intraperitoneal
  Sponsor:   Masonic Cancer Center, University of Minnesota
  Recruiting
• Epidural Stimulation After Neurologic Damage

  NCT03026816

  Conditions:   Spinal Cord Injuries;   Paraplegia, Complete
  Intervention:   Device: Epidural Spinal Cord Stimulation
  Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   Minnesota Office of Higher Education;   Minneapolis Veterans Affairs Medical Center;   Hennepin Healthcare Research Institute.;   Hennepin County Medical Center, Minneapolis
  Recruiting
• Ph I Trial of NAM NK Cells and IL-2 for Adult Pts With MM and NHL

  NCT03019666

  Conditions:   Multiple Myeloma;   Non-Hodgkin Lymphoma;   Diffuse Large B Cell Lymphoma;   Mantle-Cell Lymphoma;   Follicular Lymphoma;   Indolent B Cell Lymphoma;   Primary Mediastinal Lymphoma;   Lymphoplasmacytic Lymphoma
  Intervention:   Biological: Nicotinamide Expanded Haploidentical or Mismatched Related Donor Natural Killer Cells
  Sponsor:   Masonic Cancer Center, University of Minnesota
  Recruiting
• Microbiota or Placebo After Antimicrobial Therapy for Recurrent C. Difficile at Home (MATCH)

  NCT03005379

  Condition:   Clostridium Difficile Infection
  Interventions:   Drug: Fecal Microbiota Therapy (FMT);   Drug: Placebo
  Sponsor:   VA Office of Research and Development
  Recruiting
• Glucobrassicin-Brussel Sprout Effect on D10 Phe Metabolism

  NCT02999399

  Condition:   Smoking
  Interventions:   Other: Brussel Sprouts;   Drug: Deuterated Phenanthrene
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• Relapse Prophylaxis With N-803 for AML and MDS Pts Following Allo HSCT

  NCT02989844

  Conditions:   Acute Myelogenous Leukemia (AML);   Myelodysplastic Syndrome (MDS)
  Intervention:   Drug: N-803
  Sponsor:   Masonic Cancer Center, University of Minnesota
  Recruiting
• Assessment of Brain Activities in Cervical Dystonia

  NCT02959645

  Condition:   Cervical Dystonia
  Intervention:  
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• The Residential Care Transition Module

  NCT02915939

  Conditions:   Alzheimer Disease;   Dementia
  Intervention:   Behavioral: The Residential Care Transition Module
  Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   Johns Hopkins University;   NYU Langone Health;   Benjamin Rose Institute;   Emory University
  Recruiting
• The LoBAG Diet and Type 2 Diabetes Mellitus

  NCT02717078

  Condition:   Type 2 Diabetes Mellitus
  Intervention:   Other: Diet Therapy
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• Anti-inflammatory Therapy to Improve Outcomes After TPIAT

  NCT02713997

  Condition:   Pancreatitis, Chronic; Diabetes; Transplant
  Interventions:   Drug: etanercept;   Drug: Alpha 1-Antitrypsin
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• Use of Entresto Sacubitril/Valsartan for the Treatment of Peripheral Arterial Disease

  NCT02636283

  Condition:   Peripheral Arterial Disease
  Interventions:   Drug: Entresto;   Drug: Placebo group
  Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   American Heart Association
  Recruiting
• Accelerated Contrast-Enhanced High Resolution Whole Heart Cardiac MRI

  NCT02550366

  Condition:   Cardiac Disease
  Intervention:   Drug: MRI Contrast
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• Beta-blockers in Pulmonary Arterial Hypertension

  NCT02507011

  Condition:   Pulmonary Arterial Hypertension
  Interventions:   Drug: Carvedilol;   Drug: Placebo
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• Predicting Rupture of Abdominal Aortic Aneurysm (AAA) by Anatomic and Hemodynamic Markers From In-vivo and In-vitro Imaging.

  NCT02463760

  Condition:   Aortic Aneurysm, Abdominal
  Intervention:   Other: Medical imaging
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• MRI Technical Development and Applications in Kidney Disease

  NCT02421497

  Conditions:   Chronic Kidney Diseases;   Kidney Transplantation;   Dialysis;   Cognition Disorders
  Intervention:  
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• Treatment of Chronic Itch in Atopic Dermatitis (Eczema)

  NCT02268448

  Condition:   Cutaneous Nerves CNS Itch
  Interventions:   Drug: Clonidine;   Drug: Naltrexone
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• The Effect of Chlorhexidine on the Oral and Lung Microbiota in Chronic Obstructive Pulmonary Disease

  NCT02252588

  Condition:   Chronic Obstructive Pulmonary Disease
  Interventions:   Drug: Chlorhexidine;   Other: Placebo
  Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   Veterans Medical Research Foundation;   Flight Attendant Medical Research Institute
  Recruiting
• Mapping Chemical and Microbiological Heterogeneity Throughout Explanted Cystic Fibrosis Lung Specimens

  NCT02128711

  Condition:   Cystic Fibrosis
  Intervention:  
  Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   National Heart, Lung, and Blood Institute (NHLBI)
  Recruiting
• A Proactive Walking Trial to Reduce Pain in Black Veterans

  NCT01983228

  Condition:   Musculoskeletal Pain
  Intervention:   Behavioral: Intervention Condition
  Sponsor:   VA Office of Research and Development
  Recruiting
• Spinal Cord Stimulation to Treat Hypertension

  NCT02828436

  Condition:   Hypertension
  Interventions:   Device: Precision Spectra System;   Behavioral: Exercise Intervention
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• Neoadjuvant Combination Targeted and Immunotherapy for Patients With High-Risk Stage III Melanoma

  NCT03554083

  Conditions:   Clinical Stage III Cutaneous Melanoma AJCC v8;   Pathologic Stage III Cutaneous Melanoma AJCC v8;   Pathologic Stage IIIA Cutaneous Melanoma AJCC v8;   Pathologic Stage IIIB Cutaneous Melanoma AJCC v8;   Pathologic Stage IIIC Cutaneous Melanoma AJCC v8;   Pathologic Stage IIID Cutaneous Melanoma AJCC v8
  Interventions:   Drug: Atezolizumab;   Drug: Cobimetinib;   Drug: Vemurafenib
  Sponsors:   Mayo Clinic;   National Cancer Institute (NCI);   Genentech, Inc.;   Stand Up To Cancer
  Recruiting
• Safety and Efficacy Study of the SoundBite™ Crossing System With ACTIVE Wire in Coronary CTOs.

  NCT03521804

  Condition:   Chronic Total Occlusion of Coronary Artery
  Intervention:   Device: SoundBite™ Crossing System Active Wire 14
  Sponsors:   SoundBite Medical Solutions, Inc.;   ethica Clinical Research Inc.;   Cardiovascular Research Foundation, New York
  Recruiting
• Role of Oxidative Stress and Inflammation in Type 1 Gaucher Disease (GD1)

  NCT02583672

  Condition:   Gaucher Disease Type 1
  Intervention:   Drug: N-acetylcysteine
  Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   Rare Diseases Clinical Research Network;   National Center for Advancing Translational Science (NCATS);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   National Institute of Neurological Disorders and Stroke (NINDS);   Lysosomal Disease Network
  Recruiting
• Study Of Drinks With Artificial Sweeteners in People With Type 2 Diabetes

  NCT03944616

  Condition:   Type 2 Diabetes
  Interventions:   Behavioral: Diet Beverage;   Behavioral: Water
  Sponsors:   University of California, Irvine;   University of Minnesota, MN;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
  Recruiting
• Pioglitazone for the Treatment of Alcohol Use Disorder

  NCT03864146

  Condition:   Alcohol Use Disorder
  Intervention:   Behavioral: Brief Behavioral Compliance Enhancement Treatment
  Sponsor:   VA Office of Research and Development
  Recruiting
• Seven vs. 14 Days Treatment for Male Urinary Tract Infection

  NCT01994538

  Condition:   Urinary Tract Infections
  Interventions:   Other: Longer therapy duration;   Other: Shorter therapy duration
  Sponsor:   VA Office of Research and Development
  Recruiting
• Lung Volume Recruitment Combined With Expiratory Muscle Strength Training in ALS

  NCT03202017

  Condition:   Amyotrophic Lateral Sclerosis
  Interventions:   Procedure: Expiratory Muscle Strength Training (EMST);   Procedure: EMST + Lung Volume Recruitment (LVR)
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• Phase I/II Study of APS001F With Flucytosine and Maltose in Solid Tumors

  NCT01562626

  Conditions:   Tumors;   Neoplasms;   Cancer
  Interventions:   Drug: APS001F;   Drug: Flucytosine (5-FC);   Drug: 10% maltose
  Sponsor:   Anaeropharma Science, Inc.
  Recruiting
• Improving Outcome for Family Caregivers of Older Adults With Complex Conditions: The Adult Day Plus (ADS Plus) Program

  NCT02927821

  Condition:   Stress
  Intervention:   Behavioral: ADS Plus
  Sponsors:   Johns Hopkins University;   University of Minnesota - Clinical and Translational Science Institute;   National Institute on Aging (NIA)
  Recruiting
• Study of Palifermin (Kepivance) in Persons Undergoing Unrelated Donor Allogeneic Hematopoietic Cell Transplantation

  NCT02356159

  Conditions:   Myelodysplastic Syndrome;   Hodgkin's Lymphoma;   Non-Hodgkin's Lymphoma;   Acute Leukemia;   Multiple Myeloma
  Interventions:   Biological: Rituximab;   Drug: Conditioning Chemotherapy;   Drug: TMS;   Drug: FLAG;   Drug: EPOCH-F;   Procedure: Hematopoietic Stem Cell Transplant;   Drug: Palifermin
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Levetiracetam for Alzheimer's Disease-Associated Network Hyperexcitability

  NCT02002819

  Condition:   Alzheimer's Disease
  Intervention:   Drug: levetiracetam
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• EXPAREL Facia Iliaca Compartment Block for Intertrochanteric Hip Fracture

  NCT03955458

  Conditions:   Hip Fractures;   Intertrochanteric Fractures
  Interventions:   Drug: EXPAREL;   Drug: Ropivacaine;   Drug: Bupivacaine Hydrochloride
  Sponsor:   Pacira Pharmaceuticals, Inc
  Recruiting
• Non-Invasive and Non-Contact Intracranial Pressure Waveform Recording Using Dynamic Video Ophthalmoscopy

  NCT04046523

  Condition:   Intracranial Pressure Increase
  Intervention:   Device: Video ophthalmoscope
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• Minnesota Adrenoleukodystrophy Registry Study (MARS) and Biobank

  NCT03789721

  Condition:   ALD (Adrenoleukodystrophy)
  Interventions:   Other: Medical Record Abstraction;   Other: Biospecimen Sample Collection
  Sponsor:   Masonic Cancer Center, University of Minnesota
  Recruiting
• Monitoring of Immune and Microbial Reconstitution in (HCT) and Novel Immunotherapies

  NCT03557749

  Conditions:   Immune and Microbial Reconstitution;   Systemic Viral Infection;   Acute-graft-versus-host Disease;   Chronic Graft-versus-host-disease;   Recurrent Malignancy;   Cytokine Release Syndrome;   Allogenic Related Donors;   Cell Therapy/Immunotherapy Patients
  Interventions:   Diagnostic Test: Blood Sample;   Diagnostic Test: Stool Sample;   Diagnostic Test: Urine Sample;   Diagnostic Test: Bronchoalveolar Lavage (BAL) fluid;   Diagnostic Test: Gastrointestinal biopsy x 2-4;   Diagnostic Test: Skin biopsy;   Diagnostic Test: Skin, mouth, and/or ocular swab;   Diagnostic Test: Apheresis Product;   Diagnostic Test: Final cellular product
  Sponsor:   Masonic Cancer Center, University of Minnesota
  Recruiting
• International PPB/DICER1 Registry

  NCT03382158

  Conditions:   Pleuropulmonary Blastoma;   Sertoli-Leydig Cell Tumor;   DICER1 Syndrome;   Cystic Nephroma;   Wilms Tumor;   Pineoblastoma;   Renal Sarcoma;   Nodular Hyperplasia of Thyroid;   Nasal Chondromesenchymal Hamartoma;   Ciliary Body Medulloepithelioma;   Neuroblastoma;   Pituitary Cancer;   Embryonal Rhabdomyosarcoma
  Intervention:  
  Sponsors:   Children's Hospitals and Clinics of Minnesota;   Children's Research Institute;   Washington University School of Medicine;   ResourcePath, LLC;   Beijing Children's Hospital;   University of Cambridge;   Emory University;   Dana-Farber Cancer Institute
  Recruiting
• Auto Stem Cell Transplant for Lymphoma Patients

  NCT03125642

  Conditions:   Non-Hodgkin Lymphoma;   Hodgkin Lymphoma
  Interventions:   Drug: Etoposide;   Drug: BCNU;   Drug: AraC;   Drug: Melphalan;   Procedure: Peripheral blood stem cell transplantation;   Biological: G-CSF;   Drug: Cyclophosphamide;   Radiation: Total Body Irradiation
  Sponsor:   Masonic Cancer Center, University of Minnesota
  Recruiting
• The Impact of Tibial Tubercle-trochlear Groove Distance and Patellar Height on the Outcome of Isolated Medial Patellofemoral Ligament Reconstruction

  NCT03076008

  Condition:   Patellar Dislocation
  Intervention:   Other: Observational
  Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine;   Ohio State University;   OrthoSport Victoria
  Recruiting
• Reduced Intensity (RIC) Conditioning And Transplantation of HLA-Haploidentical Related Hematopoietic

  NCT02988466

  Condition:   Hematologic Malignancies
  Interventions:   Biological: Haplo HCT <55 years old;   Biological: Haplo HCT ≥55 years old;   Drug: GVHD Prophylaxis;   Biological: Haplo HCT ≥55 and < 65 years old;   Biological: Haplo HCT ≥65 and ≤75 years old
  Sponsor:   Masonic Cancer Center, University of Minnesota
  Recruiting
• New Ulm at HOME (Healthy Offerings Via the Mealtime Environment), NU-HOME

  NCT02973815

  Conditions:   Obesity, Childhood;   Physical Activity;   Food Intake;   Rural Health
  Intervention:   Behavioral: NU-HOME Intervention
  Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   Allina Health System;   Minneapolis Heart Institute Foundation
  Recruiting
• UCB Transplant for Hematological Diseases Using a Non Myeloablative Prep

  NCT02722668

  Conditions:   Acute Leukemia;   Acute Myeloid Leukemia;   Acute Lymphoblastic Leukemia/Lymphoma;   Burkitt's Lymphoma;   Natural Killer Cell Malignancies;   Chronic Myelogenous Leukemia;   Myelodysplastic Syndrome;   Large-cell Lymphoma;   Hodgkin Lymphoma;   Multiple Myeloma;   Relapsed Chronic Lymphocytic Leukemia;   Relapsed Small Lymphocytic Lymphoma;   Marginal Zone B-cell Lymphoma;   Follicular Lymphoma;   Lymphoplasmacytic Lymphoma;   Mantle-cell Lymphoma;   Prolymphocytic Leukemia;   Bone Marrow Failure Syndromes;   Myeloproliferative Neoplasms/Myelofibrosis;   Biphenotypic/Undifferentiated/Prolymphocytic Leukemias;   MRD Positive Leukemia;   Leukemia or MDS in Aplasia;   Relapsed T-Cell Lymphoma;   Relapsed Multiple Myeloma;   Plasma Cell Leukemia
  Interventions:   Drug: Fludarabine;   Drug: Cyclophosphamide;   Drug: MMF;   Drug: Sirolimus;   Radiation: TBI;   Biological: Umbilical cord blood cell infusion;   Biological: ATG
  Sponsor:   Masonic Cancer Center, University of Minnesota
  Recruiting
• Exemestane in Post-Menopausal Women With NSCLC

  NCT02666105

  Condition:   Non-Small Cell Lung Cancer
  Intervention:   Drug: Exemestane
  Sponsor:   Masonic Cancer Center, University of Minnesota
  Recruiting
• Allo HSCT Using RIC for Hematological Diseases

  NCT02661035

  Conditions:   Acute Myelogenous Leukemia;   Acute Lymphocytic Leukemia;   Chronic Myelogenous Leukemia;   Plasma Cell Leukemia;   Myelodysplastic Syndromes;   Chronic Lymphocytic Leukemia;   Small Lymphocytic Lymphoma;   B-Cell Lymphoma;   Follicular Lymphoma;   Lymphoplasmacytic Lymphoma;   Mantle-Cell Lymphoma;   Prolymphocytic Leukemia;   Lymphoblastic Lymphoma;   Burkitt's Lymphoma;   Non-Hodgkin's Lymphoma;   Multiple Myeloma;   Myeloproliferative Syndromes;   Hematological Diseases
  Interventions:   Drug: Allopurinol;   Drug: Fludarabine;   Drug: Cyclophosphamide;   Drug: ATG;   Radiation: TBI;   Drug: Tacrolimus;   Drug: MMF;   Biological: Peripheral Blood Stem Cells;   Biological: Related or Unrelated Bone Marrow Cells
  Sponsor:   Masonic Cancer Center, University of Minnesota
  Recruiting
• Gulf War Illness Inflammation Reduction Trial

  NCT02506192

  Conditions:   Chronic Inflammation;   Chronic Pain;   Fatigue;   Cognitive Impairment
  Interventions:   Drug: Delayed-Release Prednisone;   Drug: Placebo
  Sponsors:   Minneapolis Veterans Affairs Medical Center;   United States Department of Defense
  Recruiting
• Hematopoietic Stem Cell Transplant for Dyskeratosis Congenita or Severe Aplastic Anemia

  NCT02162420

  Conditions:   Dyskeratosis Congenita;   Aplastic Anemia
  Interventions:   Drug: Alemtuzumab;   Drug: Fludarabine;   Drug: Cyclophosphamide;   Radiation: Total Body Irradiation;   Biological: Stem Cell Transplant;   Drug: Anti-thymocyte globulin
  Sponsor:   Masonic Cancer Center, University of Minnesota
  Recruiting
• Treatment of Graft Failure After Hematopoietic Stem Cell Transplantation

  NCT02161783

  Conditions:   Primary Graft Failure;   Secondary Graft Failure
  Interventions:   Drug: Fludarabine;   Drug: Cyclophosphamide;   Radiation: Total Body Irradiation;   Biological: Hematopoietic stem cell infusion
  Sponsor:   Masonic Cancer Center, University of Minnesota
  Recruiting
• ValGanciclovir Versus ValAcyclovir for Viral Prophylaxis in Kidney Transplantation

  NCT01972035

  Conditions:   Transplantation Infection;   Epstein-Barr Virus Infections;   Cytomegalovirus Infections
  Interventions:   Drug: Valacyclovir;   Drug: Valganciclovir
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• International Ovarian & Testicular Stromal Tumor Registry

  NCT01970696

  Conditions:   Ovarian Stromal Tumor;   Testicular Stromal Tumors;   Ovarian Small Cell Carcinoma;   DICER1 Gene Mutation
  Intervention:  
  Sponsors:   Children's Hospitals and Clinics of Minnesota;   Children's Research Institute;   Dana-Farber Cancer Institute;   Washington University School of Medicine;   University of Texas Southwestern Medical Center;   M.D. Anderson Cancer Center;   Children's Hospital Colorado;   Rutgers University;   Massachusetts General Hospital;   Klinikum Dortmund Wirbelsäulenchirurgie;   ResourcePath, LLC
  Recruiting
• Protocol For A Research Database For Hematopoietic Stem Cell Transplantation, Other Cellular Therapies and Marrow Toxic Injuries

  NCT01166009

  Conditions:   Autologous Stem Cell Transplantation;   Allogeneic Stem Cell Transplantation;   Solid Tumors;   Blood Cancers
  Intervention:  
  Sponsor:   Center for International Blood and Marrow Transplant Research
  Recruiting
• Stem Cell Transplant in Treating Patients With Acute Myeloid Leukemia

  NCT00630565

  Condition:   Leukemia
  Interventions:   Biological: sargramostim;   Drug: busulfan;   Drug: cyclophosphamide;   Drug: dexamethasone;   Drug: etoposide;   Procedure: bone marrow transplantation;   Procedure: hematopoietic stem cell transplantation;   Procedure: peripheral blood stem cell transplantation;   Radiation: total-body irradiation
  Sponsor:   Masonic Cancer Center, University of Minnesota
  Recruiting
• Natural History and Structural Functional Relationships in Fabry Renal Disease Treatment Outcomes(Changes)in Fabry Renal Disease Study

  NCT01581424

  Condition:   Fabry Disease
  Intervention:  
  Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   Rare Diseases Clinical Research Network;   National Center for Advancing Translational Science (NCATS);   National Institute of Neurological Disorders and Stroke (NINDS);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   Washington University School of Medicine;   Haukeland University Hospital
  Recruiting
• Alport Syndrome Treatments and Outcomes Registry

  NCT00481130

  Condition:   Alport Syndrome
  Intervention:  
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors

  NCT00432094

  Conditions:   Childhood Germ Cell Tumor;   Ovarian Cancer;   Teratoma
  Interventions:   Drug: carboplatin;   Drug: etoposide;   Drug: ifosfamide;   Drug: paclitaxel;   Drug: thiotepa;   Procedure: autologous hematopoietic stem cell transplantation;   Drug: Mesna;   Biological: filgrastim
  Sponsor:   Masonic Cancer Center, University of Minnesota
  Recruiting
• A Test-Drive Strategy for the Prescription of Prosthetic Feet for People With Leg Amputations

  NCT03651830

  Condition:   Amputation
  Interventions:   Device: Prosthetic Foot Emulator;   Device: Commercially available prosthetic feet
  Sponsors:   Seattle Institute for Biomedical and Clinical Research;   VA Puget Sound Health Care System;   Minneapolis Veterans Affairs Medical Center;   Brooke Army Medical Center;   Stanford University;   University of Washington
  Recruiting
• Long-term, Non-interventional, Observational Study Following Treatment With Fate Therapeutics FT500 Cellular Immunotherapy

  NCT04106167

  Conditions:   Advanced Solid Tumor;   Lymphoma;   Gastric Cancer;   Colorectal Cancer;   Head and Neck Cancer;   Squamous Cell Carcinoma;   EGFR Positive Solid Tumor;   HER2-positive Breast Cancer;   Hepatocellular Carcinoma;   Small-cell Lung Cancer;   Renal Cell Carcinoma;   Pancreas Cancer;   Melanoma;   NSCLC;   Urothelial Carcinoma;   Cervical Cancer;   Microsatellite Instability;   Merkel Cell Carcinoma
  Intervention:   Genetic: Allogeneic natural killer (NK) cell
  Sponsor:   Fate Therapeutics
  Recruiting
• UrApp for Childhood Nephrotic Syndrome Management (Incident Cohort)

  NCT04075656

  Condition:   Idiopathic Nephrotic Syndrome
  Interventions:   Behavioral: Standard of Care;   Behavioral: UrApp
  Sponsors:   Emory University;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
  Recruiting
• FT500 as Monotherapy and in Combination With Immune Checkpoint Inhibitors in Subjects With Advanced Solid Tumors

  NCT03841110

  Conditions:   Advanced Solid Tumors;   Lymphoma;   Gastric Cancer;   Colorectal Cancer;   Head and Neck Cancer;   Squamous Cell Carcinoma;   EGFR Positive Solid Tumor;   HER2-positive Breast Cancer;   Hepatocellular Carcinoma;   Small Cell Lung Cancer;   Renal Cell Carcinoma;   Pancreas Cancer;   Melanoma;   NSCLC;   Urothelial Carcinoma;   Cervical Cancer;   Microsatellite Instability;   Merkel Cell Carcinoma
  Interventions:   Drug: FT500;   Drug: Nivolumab;   Drug: Pembrolizumab;   Drug: Atezolizumab;   Drug: Cyclophosphamide;   Drug: Fludarabine
  Sponsor:   Fate Therapeutics
  Recruiting
• Pembrolizumab in Treating Participants With Recurrent Ovarian Cancer

  NCT03732950

  Conditions:   Recurrent Fallopian Tube Carcinoma;   Recurrent Ovarian Carcinoma;   Recurrent Primary Peritoneal Carcinoma
  Intervention:   Biological: Pembrolizumab
  Sponsors:   Jonsson Comprehensive Cancer Center;   National Cancer Institute (NCI)
  Recruiting
• Sacral Nerve Stimulation in Improving Bladder After Acute Traumatic Spinal Cord Injury

  NCT03083366

  Conditions:   Spinal Cord Injury, Acute;   Neurogenic Bladder;   Incontinence;   Urinary Tract Infections
  Intervention:   Device: PrimeAdvanced Surescan 97702 Neurostimulator - Medtronic (Minneapolis, MN)
  Sponsors:   University of Utah;   University of Minnesota - Clinical and Translational Science Institute;   University of Michigan
  Recruiting
• Allogeneic Hematopoietic Cell Transplantation for Disorders of T-cell Proliferation and/or Dysregulation

  NCT03663933

  Conditions:   Lymphoproliferative Disorders;   Autoimmune Lymphoproliferative;   Primary T-cell Immunodeficiency Disorders;   Immune System Diseases;   Common Variable Immunodeficiency
  Interventions:   Drug: Immunosuppression Only Conditioning (IOC);   Drug: Reduced Intensity Conditioning (RIC);   Drug: GVHD Prophylaxis;   Procedure: Allogeneic HSC
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Improving Veteran Adherence to Treatment for PTSD Through Partnering With Families

  NCT03256227

  Condition:   Posttraumatic Stress Disorder
  Interventions:   Behavioral: Family Supported Prolonged Exposure;   Behavioral: Standard Prolonged Exposure
  Sponsor:   VA Office of Research and Development
  Recruiting
• Aging and Cognitive Health Evaluation in Elders (ACHIEVE)

  NCT03243422

  Conditions:   Aging;   Cognitive Decline
  Interventions:   Other: Successful aging education intervention;   Other: Hearing intervention
  Sponsors:   Johns Hopkins Bloomberg School of Public Health;   University of North Carolina;   University of South Florida;   University of Pittsburgh;   University of Mississippi Medical Center;   Wake Forest University;   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• A Phase 1 Study to Evaluate SNDX- 6352 in Subjects With Active cGVHD

  NCT03604692

  Condition:   Chronic Graft-versus-host-disease
  Intervention:   Drug: SNDX-6352
  Sponsor:   Syndax Pharmaceuticals
  Recruiting
• A Study of CNSA-001 in Primary Tetrahydrobiopterin Deficient Patients With Hyperphenylalaninemia

  NCT03519711

  Conditions:   BH4 Deficiency;   Hyperphenylalaninemia, Non-Phenylketonuric
  Intervention:   Drug: CNSA-001
  Sponsor:   Censa Pharmaceuticals, Inc.
  Recruiting
• A Registry of Patients With Primary Choroidal Melanoma (CM) or Indeterminate Lesions (ILs)

  NCT03941379

  Conditions:   Choroidal Melanoma;   Indeterminate Lesions of Eye
  Intervention:  
  Sponsor:   Aura Biosciences
  Recruiting
• walk2Wellness: Long-term Effects of Walkasins® Wearable Sensory Prosthesis

  NCT03538756

  Conditions:   Sensory Peripheral Neuropathy;   Balance; Distorted;   Sensation Disorders
  Intervention:   Device: Walkasins
  Sponsor:   RxFunction Inc.
  Recruiting
• FATE-NK100 as Monotherapy and in Combination With Monoclonal Antibody in Subjects With Advanced Solid Tumors

  NCT03319459

  Conditions:   HER2 Positive Gastric Cancer;   Colorectal Cancer;   Head and Neck Squamous Cell Carcinoma;   EGFR Positive Solid Tumor;   Advanced Solid Tumors;   HER2-positive Breast Cancer;   Hepatocellular Carcinoma;   Non Small Cell Lung Cancer;   Renal Cell Carcinoma;   Pancreatic Cancer;   Melanoma
  Interventions:   Drug: FATE-NK100;   Drug: Cetuximab;   Drug: Trastuzumab
  Sponsor:   Fate Therapeutics
  Recruiting
• Exemestane in Treating Patients With Complex Atypical Hyperplasia of the Endometrium/Endometrial Intraepithelial Neoplasia or Low Grade Endometrial Cancer

  NCT03300557

  Conditions:   Atypical Hyperplasia;   Endometrial Intraepithelial Neoplasia;   FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma;   FIGO Grade 2 Endometrial Endometrioid Adenocarcinoma
  Interventions:   Drug: Exemestane;   Other: Laboratory Biomarker Analysis;   Other: Pharmacokinetic Study;   Other: Questionnaire Administration
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Trial Comparing Relapse Rates Between Standard Ureteroscopic Removal Of Ureteral Stone And Standard Removal With Additional Ureterorenic Clearing Of Non-Symptomatic Stones In The Kidney

  NCT02210650

  Condition:   Ureteral Stones
  Interventions:   Procedure: Ureteral stone removal;   Procedure: Asymptomatic kidney stones and ureteral stone removed
  Sponsors:   Indiana Kidney Stone Institute;   University of Washington Medical Center Department of Urology (Seattle, WA);   VA Puget Sound Health Care System
  Recruiting
• Pelvital Stress Urinary Incontinence Training Device: P-SUIT

  NCT02954042

  Condition:   Incontinence
  Interventions:   Device: Pelvital probe;   Device: Placebo Probe
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Recruiting
• Retinoid 9cUAB30 in Producing a Biologic Effect in Patients With Early Stage Breast Cancer

  NCT02876640

  Conditions:   Early-Stage Breast Carcinoma;   Invasive Breast Carcinoma
  Interventions:   Drug: Retinoid 9cUAB30;   Procedure: Therapeutic Conventional Surgery
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• CoQ10 in Gulf War Illness

  NCT02865460

  Conditions:   Gulf War Illness;   Chronic Fatigue;   Ubiquinol;   Coenzyme Q10
  Interventions:   Drug: Ubiquinol;   Drug: Placebo
  Sponsor:   VA Office of Research and Development
  Recruiting
• Low InTensity Exercise Intervention in PAD

  NCT02538900

  Condition:   Peripheral Artery Disease
  Interventions:   Behavioral: Exercise;   Other: Attention control
  Sponsors:   Northwestern University;   National Heart, Lung, and Blood Institute (NHLBI)
  Recruiting
• Phase II Nivolumab and Ramucirumab for Patients With Previously-Treated Mesothelioma

  NCT03502746

  Condition:   Mesothelioma, Malignant
  Interventions:   Drug: Nivolumab;   Drug: Ramucirumab
  Sponsors:   Arkadiusz Z. Dudek, MD;   HealthPartners Institute Regions Cancer Care Center;   Eli Lilly and Company;   Bristol-Myers Squibb
  Recruiting
• Psychosocial Rehabilitation After Moral Injury and Loss With Adaptive Disclosure

  NCT03056157

  Conditions:   Post-traumatic Stress Disorder;   Moral Injury;   Traumatic Loss
  Interventions:   Behavioral: Adaptive Disclosure for Moral Injury and Loss;   Behavioral: Present Centered Therapy
  Sponsors:   VA Office of Research and Development;   Minneapolis Veterans Affairs Medical Center;   San Francisco Veterans Affairs Medical Center;   San Diego Veterans Healthcare System
  Recruiting
• Obinutuzumab in cGVHD After Allogeneic Peripheral Blood Stem Cell Transplantation

  NCT02867384

  Condition:   Graft vs. Host Disease
  Interventions:   Drug: Obinutuzumab;   Drug: Placebo
  Sponsors:   Dana-Farber Cancer Institute;   Roche-Genentech
  Recruiting
• Mindful Movement for Physical Activity and Wellbeing in Older Adults- A Hybrid Effectiveness-Implementation Study

  NCT03929393

  Conditions:   Physical Inactivty;   Wellbeing;   Mindfulness
  Interventions:   Behavioral: Mindful Movement;   Other: Keys to Health & Wellbeing
  Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   YMCA
  Recruiting
• Testing The Addition of a New Anti-cancer Drug, Venetoclax, to the Usual Treatment (Ibrutinib and Obinutuzumab) in Untreated, Older Patients With Chronic Lymphocytic Leukemia

  NCT03737981

  Condition:   Chronic Lymphocytic Leukemia
  Interventions:   Drug: Ibrutinib;   Biological: Obinutuzumab;   Other: Observation;   Drug: Venetoclax
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Palbociclib and Letrozole or Fulvestrant in Treating Patients With Estrogen Receptor Positive, HER2 Negative Metastatic Breast Cancer

  NCT03633331

  Conditions:   Estrogen Receptor-positive Breast Cancer;   HER2/Neu Negative;   Stage IV Breast Cancer AJCC v6 and v7
  Interventions:   Drug: Palbociclib;   Drug: Letrozole;   Drug: Fulvestrant;   Other: Questionnaire Administration;   Other: Quality-of-Life Assessment
  Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI)
  Recruiting
• Dried Blood Spot Testing of CMV Detection in HCT Recipients

  NCT03910478

  Condition:   Cytomegalovirus Infection
  Interventions:   Device: DBS Self-Collection Kit;   Other: Standard Control Strategy
  Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
  Recruiting
• Evaluation of Transcatheter Aortic Valve Replacement Compared to SurveilLance for Patients With AsYmptomatic Severe Aortic Stenosis

  NCT03042104

  Conditions:   Aortic Stenosis;   Heart Diseases
  Intervention:   Device: Edwards SAPIEN 3 THV
  Sponsor:   Edwards Lifesciences
  Recruiting
• Diuretic Comparison Project

  NCT02185417

  Condition:   Hypertension
  Interventions:   Drug: Hydrochlorothiazide (HCTZ);   Drug: Chlorthalidone
  Sponsor:   VA Office of Research and Development
  Recruiting
• Mepo for EoE Study

  NCT03656380

  Conditions:   EoE;   Eosinophilic Esophagitis
  Interventions:   Drug: Mepolizumab 300 mg;   Drug: Mepolizumab 100 mg;   Other: Placebo
  Sponsors:   University of North Carolina, Chapel Hill;   GlaxoSmithKline;   University of Utah;   Northwestern University;   Minnesota Gastroenterology, P.A.
  Recruiting
• RESOLUTE ONYX Post-Approval Study (Bifurcation Cohort)

  NCT03584464

  Condition:   Coronary Artery Disease
  Intervention:   Device: Resolute Onyx™ Zotarolimus-Eluting Coronary Stent System
  Sponsor:   Medtronic Vascular
  Recruiting
• Adenosine Contrast CorrELations in Evaluating RevAscularizaTION

  NCT03557385

  Condition:   Percutaneous Coronary Intervention
  Interventions:   Drug: Iopamidol;   Drug: adenosine;   Device: Navvus® Catheter;   Device: CVi® Contrast Delivery System
  Sponsors:   Duke University;   Acist Medical Systems
  Recruiting
• Vaccine Therapy in Reducing the Frequency of Cytomegalovirus Events in Patients With Hematologic Malignancies Undergoing Donor Stem Cell Transplant

  NCT02396134

  Conditions:   Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive;   Adult Acute Lymphoblastic Leukemia in Remission;   Adult Acute Myeloid Leukemia in Remission;   Adult Hodgkin Lymphoma;   Adult Non-Hodgkin Lymphoma;   Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive;   Cytomegaloviral Infection;   Hematopoietic and Lymphoid Cell Neoplasm;   HLA-A*0201 Positive Cells Present;   Myelodysplastic Syndrome;   Adult Lymphoblastic Lymphoma;   Chronic Lymphocytic Leukemia;   Myelofibrosis;   Myeloproliferative Neoplasm
  Interventions:   Biological: CMVpp65-A*0201 peptide vaccine;   Other: Placebo;   Other: Laboratory Biomarker Analysis
  Sponsors:   City of Hope Medical Center;   National Cancer Institute (NCI)
  Recruiting
• A Study of CCX140-B in Subjects With Primary FSGS and Nephrotic Syndrome

  NCT03703908

  Condition:   Focal Segmental Glomerulosclerosis
  Intervention:   Drug: CCX140-B
  Sponsor:   ChemoCentryx
  Recruiting
• Phase II Trial of Continuation Therapy in Advanced NSCLC

  NCT03083808

  Condition:   Non-Small-Cell Lung Cancer
  Intervention:   Drug: Pembrolizumab
  Sponsors:   Greg Durm, MD;   Merck Sharp & Dohme Corp.;   Big Ten Cancer Research Consortium
  Recruiting
• Wellclub Shoulder Therapy Outcome Validation

  NCT02954185

  Condition:   Shoulder Pain
  Interventions:   Device: WellClub;   Behavioral: Standard Therapy
  Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   Fairview Sports Physical Therapy Program
  Recruiting
• Naloxegol in Treating Patients With Stage IIIB-IV Non-small Cell Lung Cancer

  NCT03087708

  Conditions:   Stage IIIB Non-Small Cell Lung Cancer;   Stage IV Non-small Cell Lung Cancer
  Interventions:   Drug: Naloxegol;   Other: Placebo;   Other: Laboratory Biomarker Analysis;   Other: Quality-of-Life Assessment
  Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI)
  Recruiting
• Firstline Pembrolizumab Alone or in Combination With Pemetrexed and Carboplatin in Induction/Maintenance or Postprogression in Treating Patients With Stage IV Non-squamous Non-small Cell Lung Cancer

  NCT03793179

  Conditions:   Lung Non-Squamous Non-Small Cell Carcinoma;   Stage IIIB Lung Cancer AJCC v8;   Stage IIIC Lung Cancer AJCC v8;   Stage IVA Lung Cancer AJCC v8
  Interventions:   Drug: Carboplatin;   Biological: Pembrolizumab;   Drug: Pemetrexed
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Ibrutinib and Obinutuzumab With or Without Venetoclax in Treating Patients With Chronic Lymphocytic Leukemia

  NCT03701282

  Conditions:   Chronic Lymphocytic Leukemia;   Small Lymphocytic Lymphoma
  Interventions:   Drug: Ibrutinib;   Biological: Obinutuzumab;   Other: Quality-of-Life Assessment;   Drug: Venetoclax
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Olanzapine With or Without Fosaprepitant Dimeglumine in Preventing Chemotherapy Induced Nausea and Vomiting in Cancer Patients Receiving Highly Emetogenic Chemotherapy

  NCT03578081

  Condition:   Malignant Neoplasm
  Interventions:   Drug: Palonosetron Hydrochloride;   Drug: Ondansetron Hydrochloride;   Drug: Dexamethasone;   Drug: Fosaprepitant Dimeglumine;   Drug: Olanzapine;   Other: Placebo
  Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI)
  Recruiting
• Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair

  NCT02912559

  Conditions:   Colon Adenocarcinoma;   DNA Repair Disorder;   Lynch Syndrome;   Stage III Colon Cancer AJCC v7;   Stage IIIA Colon Cancer AJCC v7;   Stage IIIB Colon Cancer AJCC v7;   Stage IIIC Colon Cancer AJCC v7
  Interventions:   Drug: Atezolizumab;   Drug: Fluorouracil;   Other: Laboratory Biomarker Analysis;   Drug: Leucovorin Calcium;   Drug: Oxaliplatin;   Other: Quality-of-Life Assessment
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

  NCT02465060

  Conditions:   Advanced Malignant Solid Neoplasm;   Bladder Carcinoma;   Breast Carcinoma;   Cervical Carcinoma;   Colon Carcinoma;   Colorectal Carcinoma;   Endometrial Carcinoma;   Esophageal Carcinoma;   Gastric Carcinoma;   Glioma;   Head and Neck Carcinoma;   Kidney Carcinoma;   Liver and Intrahepatic Bile Duct Carcinoma;   Lung Carcinoma;   Lymphoma;   Malignant Uterine Neoplasm;   Melanoma;   Ovarian Carcinoma;   Pancreatic Carcinoma;   Plasma Cell Myeloma;   Prostate Carcinoma;   Rectal Carcinoma;   Recurrent Bladder Carcinoma;   Recurrent Breast Carcinoma;   Recurrent Cervical Carcinoma;   Recurrent Colon Carcinoma;   Recurrent Colorectal Carcinoma;   Recurrent Esophageal Carcinoma;   Recurrent Gastric Carcinoma;   Recurrent Glioma;   Recurrent Head and Neck Carcinoma;   Recurrent Liver Carcinoma;   Recurrent Lung Carcinoma;   Recurrent Lymphoma;   Recurrent Malignant Solid Neoplasm;   Recurrent Melanoma;   Recurrent Ovarian Carcinoma;   Recurrent Pancreatic Carcinoma;   Recurrent Plasma Cell Myeloma;   Recurrent Prostate Carcinoma;   Recurrent Rectal Carcinoma;   Recurrent Skin Carcinoma;   Recurrent Thyroid Gland Carcinoma;   Recurrent Uterine Corpus Carcinoma;   Refractory Lymphoma;   Refractory Malignant Solid Neoplasm;   Refractory Plasma Cell Myeloma;   Skin Carcinoma;   Thyroid Gland Carcinoma;   Uterine Corpus Cancer
  Interventions:   Drug: Adavosertib;   Drug: Afatinib;   Drug: Afatinib Dimaleate;   Drug: Binimetinib;   Drug: Capivasertib;   Drug: Copanlisib;   Drug: Copanlisib Hydrochloride;   Drug: Crizotinib;   Other: Cytology Specimen Collection Procedure;   Drug: Dabrafenib;   Drug: Dabrafenib Mesylate;   Drug: Dasatinib;   Drug: Defactinib;   Drug: Defactinib Hydrochloride;   Drug: Erdafitinib;   Drug: FGFR Inhibitor AZD4547;   Drug: Ipatasertib;   Other: Laboratory Biomarker Analysis;   Drug: Larotrectinib;   Drug: Larotrectinib Sulfate;   Biological: Nivolumab;   Drug: Osimertinib;   Drug: Palbociclib;   Biological: Pertuzumab;   Drug: PI3K-beta Inhibitor GSK2636771;   Drug: Sapanisertib;   Drug: Sunitinib Malate;   Drug: Taselisib;   Drug: Trametinib;   Biological: Trastuzumab;   Biological: Trastuzumab Emtansine;   Drug: Ulixertinib;   Drug: Vismodegib
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Crizotinib in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been Removed by Surgery and ALK Fusion Mutations (An ALCHEMIST Treatment Trial)

  NCT02201992

  Conditions:   ALK Gene Rearrangement;   ALK Gene Translocation;   ALK Positive;   Stage IB Non-Small Cell Lung Carcinoma AJCC v7;   Stage II Non-Small Cell Lung Cancer AJCC v7;   Stage IIA Non-Small Cell Lung Carcinoma AJCC v7;   Stage IIB Non-Small Cell Lung Carcinoma AJCC v7;   Stage IIIA Non-Small Cell Lung Cancer AJCC v7
  Interventions:   Other: Clinical Observation;   Drug: Crizotinib;   Other: Laboratory Biomarker Analysis
  Sponsors:   ECOG-ACRIN Cancer Research Group;   National Cancer Institute (NCI)
  Recruiting
• Genetic Testing in Screening Patients With Stage IB-IIIA Non-Small Cell Lung Cancer That Has Been or Will Be Removed by Surgery (The ALCHEMIST Screening Trial)

  NCT02194738

  Conditions:   Lung Adenocarcinoma;   Lung Large Cell Carcinoma;   Stage IB Lung Non-Small Cell Carcinoma AJCC v7;   Stage IB Lung Squamous Cell Carcinoma AJCC v7;   Stage II Lung Non-Small Cell Cancer AJCC v7;   Stage II Lung Squamous Cell Carcinoma AJCC v7;   Stage IIA Lung Non-Small Cell Carcinoma AJCC v7;   Stage IIA Lung Squamous Cell Carcinoma AJCC v7;   Stage IIB Lung Non-Small Cell Carcinoma AJCC v7;   Stage IIB Lung Squamous Cell Carcinoma AJCC v7;   Stage IIIA Lung Non-Small Cell Cancer AJCC v7;   Stage IIIA Lung Squamous Cell Carcinoma AJCC v7
  Interventions:   Other: Clinical Observation;   Drug: Crizotinib;   Other: Cytology Specimen Collection Procedure;   Drug: Erlotinib Hydrochloride;   Biological: Nivolumab;   Other: Placebo
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Erlotinib Hydrochloride in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been Completely Removed by Surgery (An ALCHEMIST Treatment Trial)

  NCT02193282

  Conditions:   EGFR Exon 19 Deletion Mutation;   EGFR NP_005219.2:p.L858R;   Stage IB Lung Non-Small Cell Carcinoma AJCC v7;   Stage II Lung Non-Small Cell Cancer AJCC v7;   Stage IIA Lung Non-Small Cell Carcinoma AJCC v7;   Stage IIB Lung Non-Small Cell Carcinoma AJCC v7;   Stage IIIA Lung Non-Small Cell Cancer AJCC v7
  Interventions:   Other: Clinical Observation;   Drug: Erlotinib Hydrochloride;   Other: Laboratory Biomarker Analysis;   Other: Placebo
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Efficacy and Safety of Implantable Cardioverter-Defibrillator (ICD) Implantation in the Elderly

  NCT02121158

  Conditions:   Cardiomyopathy;   Coronary Artery Disease;   Congestive Heart Failure;   Myocardial Infarction
  Interventions:   Device: Implantable Cardioverter Defibrillator;   Other: Optimal Medical Therapy
  Sponsor:   VA Office of Research and Development
  Recruiting
• S1803, Daratumumab/rHuPh20 +/- Lenalidomide as Post-ASCT Maintenance for MM w/MRD to Direct Therapy Duration

  NCT04071457

  Condition:   Multiple Myeloma
  Interventions:   Drug: Lenalidomide;   Drug: Daratumumab/rHuPH20
  Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI);   Janssen, LP;   Adaptive
  Recruiting
• Bupropion in Reducing Cancer Related Fatigue in Stage I-III Breast Cancer Survivors

  NCT03996265

  Conditions:   Anatomic Stage I Breast Cancer AJCC v8;   Anatomic Stage IA Breast Cancer AJCC v8;   Anatomic Stage IB Breast Cancer AJCC v8;   Anatomic Stage II Breast Cancer AJCC v8;   Anatomic Stage IIA Breast Cancer AJCC v8;   Anatomic Stage IIB Breast Cancer AJCC v8;   Anatomic Stage III Breast Cancer AJCC v8;   Anatomic Stage IIIA Breast Cancer AJCC v8;   Anatomic Stage IIIB Breast Cancer AJCC v8;   Anatomic Stage IIIC Breast Cancer AJCC v8;   Cancer Fatigue;   Cancer Survivor;   Complete Remission;   Prognostic Stage I Breast Cancer AJCC v8;   Prognostic Stage IA Breast Cancer AJCC v8;   Prognostic Stage IB Breast Cancer AJCC v8;   Prognostic Stage II Breast Cancer AJCC v8;   Prognostic Stage IIA Breast Cancer AJCC v8;   Prognostic Stage IIB Breast Cancer AJCC v8;   Prognostic Stage III Breast Cancer AJCC v8;   Prognostic Stage IIIA Breast Cancer AJCC v8;   Prognostic Stage IIIB Breast Cancer AJCC v8;   Prognostic Stage IIIC Breast Cancer AJCC v8
  Interventions:   Drug: Bupropion Hydrochloride Controlled-release;   Other: Placebo;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration
  Sponsors:   Gary Morrow;   National Cancer Institute (NCI)
  Recruiting
• Ramucirumab and Pembrolizumab Versus Standard of Care in Treating Patients With Stage IV or Recurrent Non-small Cell Lung Cancer (A Lung-MAP Non-Match Treatment Trial)

  NCT03971474

  Conditions:   Recurrent Lung Non-Small Cell Carcinoma;   Stage IV Lung Cancer AJCC v8;   Stage IVA Lung Cancer AJCC v8;   Stage IVB Lung Cancer AJCC v8
  Interventions:   Drug: Docetaxel;   Drug: Gemcitabine;   Drug: Gemcitabine Hydrochloride;   Biological: Pembrolizumab;   Drug: Pemetrexed;   Drug: Pemetrexed Disodium;   Biological: Ramucirumab
  Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• Avelumab With or Without Cetuximab in Treating Patients With Advanced Skin Squamous Cell Cancer

  NCT03944941

  Conditions:   Skin Squamous Cell Carcinoma;   Metastatic Skin Cancer
  Interventions:   Drug: Avelumab;   Drug: Cetuximab
  Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI)
  Recruiting
• Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma

  NCT03937635

  Condition:   Smoldering Plasma Cell Myeloma
  Interventions:   Biological: Daratumumab;   Drug: Dexamethasone;   Drug: Lenalidomide;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration
  Sponsors:   ECOG-ACRIN Cancer Research Group;   National Cancer Institute (NCI)
  Recruiting
• Tenofovir Alafenamide in Preventing Liver Complications in Participants With Current or Past Hepatitis B Virus Who Are Receiving Anti-Cancer Therapy for Solid Tumors

  NCT03887702

  Conditions:   Hepatitis B Virus Positive;   Malignant Solid Neoplasm
  Interventions:   Other: Best Practice;   Other: Laboratory Biomarker Analysis;   Drug: Tenofovir Alafenamide
  Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

  NCT03866382

  Conditions:   Bladder Adenocarcinoma;   Bladder Mixed Adenocarcinoma;   Bladder Small Cell Carcinoma;   Bladder Squamous Cell Carcinoma;   Chromophobe Renal Cell Carcinoma;   Infiltrating Bladder Lymphoepithelioma-Like Carcinoma;   Infiltrating Bladder Urothelial Carcinoma;   Infiltrating Bladder Urothelial Carcinoma With Giant Cells;   Infiltrating Bladder Urothelial Carcinoma, Nested Variant;   Infiltrating Bladder Urothelial Carcinoma, Plasmacytoid Variant;   Infiltrating Bladder Urothelial Carcinoma, Sarcomatoid Variant;   Kidney Medullary Carcinoma;   Large Cell Neuroendocrine Carcinoma;   Metastatic Bladder Carcinoma;   Metastatic Bladder Large Cell Neuroendocrine Carcinoma;   Metastatic Bladder Small Cell Carcinoma;   Metastatic Bladder Squamous Cell Carcinoma;   Metastatic Infiltrating Bladder Urothelial Carcinoma, Clear Cell Variant;   Metastatic Infiltrating Bladder Urothelial Carcinoma, Lipid-Rich Variant;   Metastatic Infiltrating Bladder Urothelial Carcinoma, Micropapillary Variant;   Metastatic Infiltrating Bladder Urothelial Carcinoma, Plasmacytoid Variant;   Metastatic Infiltrating Bladder Urothelial Carcinoma, Sarcomatoid Variant;   Metastatic Kidney Medullary Carcinoma;   Metastatic Malignant Genitourinary System Neoplasm;   Metastatic Penile Carcinoma;   Metastatic Prostate Small Cell Carcinoma;   Metastatic Sarcomatoid Renal Cell Carcinoma;   Papillary Renal Cell Carcinoma;   Sarcomatoid Renal Cell Carcinoma;   Stage IV Bladder Cancer AJCC v8;   Stage IV Penile Cancer AJCC v8;   Stage IV Prostate Cancer AJCC v8;   Stage IV Renal Cell Cancer AJCC v8;   Stage IVA Bladder Cancer AJCC v8;   Stage IVA Prostate Cancer AJCC v8;   Stage IVB Bladder Cancer AJCC v8;   Stage IVB Prostate Cancer AJCC v8;   Testicular Leydig Cell Tumor;   Testicular Sertoli Cell Tumor
  Interventions:   Drug: Cabozantinib;   Drug: Cabozantinib S-malate;   Biological: Ipilimumab;   Biological: Nivolumab
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Dexamethasone in Reducing Everolimus-Induced Oral Stomatitis in Patients With Cancer

  NCT03839940

  Condition:   Malignant Neoplasm
  Interventions:   Drug: Dexamethasone;   Other: Placebo;   Other: Questionnaire;   Other: Quality-of-Life Assessment;   Drug: Everolimus
  Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI)
  Recruiting
• Testing Maintenance Immunotherapy Versus Observation in Patients With Oropharynx Cancer

  NCT03811015

  Conditions:   Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8;   Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8;   Pathologic Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8;   Pathologic Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
  Interventions:   Drug: Cisplatin;   Radiation: Intensity-Modulated Radiation Therapy;   Biological: Nivolumab;   Other: Patient Observation
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Immunotherapy With Nivolumab and Ipilimumab Followed by Nivolumab or Nivolumab With Cabozantinib for Patients With Advanced Kidney Cancer, The PDIGREE Study

  NCT03793166

  Conditions:   Clear Cell Renal Cell Carcinoma;   Metastatic Malignant Neoplasm in Lymph Node;   Metastatic Malignant Neoplasm in the Bone;   Metastatic Malignant Neoplasm in the Soft Tissues;   Metastatic Malignant Neoplasm in the Viscera;   Sarcomatoid Renal Cell Carcinoma;   Stage IV Renal Cell Cancer AJCC v8
  Interventions:   Drug: Cabozantinib;   Biological: Ipilimumab;   Biological: Nivolumab;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Gemcitabine Hydrochloride and Cisplatin With or Without Nab-Paclitaxel in Treating Patients With Newly Diagnosed Advanced Biliary Tract Cancers

  NCT03768414

  Conditions:   Stage III Distal Bile Duct Cancer AJCC v8;   Stage III Gallbladder Cancer AJCC v8;   Stage III Intrahepatic Cholangiocarcinoma AJCC v8;   Stage IIIA Distal Bile Duct Cancer AJCC v8;   Stage IIIA Gallbladder Cancer AJCC v8;   Stage IIIA Intrahepatic Cholangiocarcinoma AJCC v8;   Stage IIIB Distal Bile Duct Cancer AJCC v8;   Stage IIIB Gallbladder Cancer AJCC v8;   Stage IIIB Intrahepatic Cholangiocarcinoma AJCC v8;   Stage IV Distal Bile Duct Cancer AJCC v8;   Stage IV Gallbladder Cancer AJCC v8;   Stage IV Intrahepatic Cholangiocarcinoma AJCC v8;   Stage IVA Gallbladder Cancer AJCC v8;   Stage IVB Gallbladder Cancer AJCC v8;   Unresectable Extrahepatic Bile Duct Carcinoma;   Unresectable Gallbladder Carcinoma;   Unresectable Intrahepatic Cholangiocarcinoma
  Interventions:   Drug: Cisplatin;   Drug: Gemcitabine Hydrochloride;   Drug: Nab-paclitaxel
  Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• Biomarker/ALK Inhibitor Combinations in Treating Patients With Stage IV ALK Positive Non-squamous Non-small Cell Lung Cancer (The NCI-NRG ALK Protocol)

  NCT03737994

  Conditions:   Lung Non-Squamous Non-Small Cell Carcinoma;   Stage IV Lung Cancer AJCC v8;   Stage IVA Lung Cancer AJCC v8;   Stage IVB Lung Cancer AJCC v8
  Interventions:   Drug: Alectinib;   Drug: Brigatinib;   Drug: Carboplatin;   Drug: Ceritinib;   Drug: Cisplatin;   Drug: Crizotinib;   Drug: Ensartinib;   Drug: Lorlatinib;   Drug: Pemetrexed
  Sponsors:   National Cancer Institute (NCI);   NRG Oncology
  Recruiting
• Pembrolizumab Compared to Standard of Care Observation in Treating Patients With Completely Resected Stage I-III Merkel Cell Cancer

  NCT03712605

  Conditions:   Pathologic Stage I Merkel Cell Carcinoma AJCC v8;   Pathologic Stage II Merkel Cell Carcinoma AJCC v8;   Pathologic Stage IIA Merkel Cell Carcinoma AJCC v8;   Pathologic Stage IIB Merkel Cell Carcinoma AJCC v8;   Pathologic Stage III Merkel Cell Carcinoma AJCC v8;   Pathologic Stage IIIA Merkel Cell Carcinoma AJCC v8;   Pathologic Stage IIIB Merkel Cell Carcinoma AJCC v8
  Interventions:   Other: Best Practice;   Biological: Pembrolizumab;   Radiation: Radiation Therapy
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Daunorubicin and Cytarabine With or Without Uproleselan in Treating Older Adult Patients With Acute Myeloid Leukemia Receiving Intensive Induction Chemotherapy

  NCT03701308

  Condition:   Acute Myeloid Leukemia
  Interventions:   Drug: Cytarabine;   Drug: Daunorubicin;   Drug: Uproleselan
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Pembrolizumab in Treating Patients With Stage III-IV High-Risk Melanoma Before and After Surgery

  NCT03698019

  Conditions:   Acral Lentiginous Melanoma;   Clinical Stage III Cutaneous Melanoma AJCC v8;   Clinical Stage IV Cutaneous Melanoma AJCC v8;   Mucosal Melanoma;   Pathologic Stage III Cutaneous Melanoma AJCC v8;   Pathologic Stage IIIA Cutaneous Melanoma AJCC v8;   Pathologic Stage IIIB Cutaneous Melanoma AJCC v8;   Pathologic Stage IIIC Cutaneous Melanoma AJCC v8;   Pathologic Stage IIID Cutaneous Melanoma AJCC v8;   Pathologic Stage IV Cutaneous Melanoma AJCC v8
  Interventions:   Biological: Pembrolizumab;   Procedure: Therapeutic Conventional Surgery
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Carboplatin and Paclitaxel With or Without Ramucirumab in Treating Patients With Locally Advanced, Recurrent, or Metastatic Thymic Cancer That Cannot Be Removed by Surgery

  NCT03694002

  Conditions:   Locally Advanced Thymic Carcinoma;   Metastatic Thymic Carcinoma;   Recurrent Thymic Carcinoma;   Unresectable Thymic Carcinoma
  Interventions:   Drug: Carboplatin;   Drug: Paclitaxel;   Biological: Ramucirumab
  Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• Ruxolitinib Phosphate and Dasatinib or Nilotinib in Treating Patients With Chronic Myeloid Leukemia

  NCT03654768

  Condition:   Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive
  Interventions:   Drug: Dasatinib;   Other: Laboratory Biomarker Analysis;   Drug: Nilotinib;   Drug: Ruxolitinib Phosphate
  Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• Dose Dense Gemcitabine and Cisplatin Without Cystectomy for Patients With Muscle Invasive Bladder Urothelial Cancer and Select Genetic Alterations

  NCT03609216

  Conditions:   Infiltrating Bladder Urothelial Carcinoma;   Stage II Bladder Urothelial Carcinoma;   Stage III Bladder Urothelial Carcinoma
  Interventions:   Drug: Gemcitabine Hydrochloride;   Drug: Cisplatin;   Biological: Pegfilgrastim;   Procedure: Conventional Surgery;   Procedure: Radical Cystectomy;   Other: Chemoradiotherapy
  Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI)
  Recruiting
• S1702 Isatuximab in Treating Patients With Relapsed or Refractory Primary Amyloidosis

  NCT03499808

  Conditions:   Amorphous, Eosinophilic, and Acellular Deposit;   Constipation;   Diarrhea;   Early Satiety;   Gastrointestinal Hemorrhage;   Hepatomegaly;   Lymphadenopathy;   Macroglossia;   Nausea;   Primary Systemic Amyloidosis;   Purpura;   Recurrent Primary Amyloidosis;   Refractory Primary Amyloidosis
  Interventions:   Biological: Isatuximab;   Other: Laboratory Biomarker Analysis
  Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• Testing Ramipril to Prevent Memory Loss in People With Glioblastoma

  NCT03475186

  Conditions:   Glioblastoma;   Radiotherapy; Complications;   Cognitive Decline;   Chemoradiation
  Intervention:   Drug: Ramipril
  Sponsors:   Wake Forest University Health Sciences;   National Cancer Institute (NCI)
  Recruiting
• Study to Investigate CSL112 in Subjects With Acute Coronary Syndrome

  NCT03473223

  Condition:   Acute Coronary Syndrome
  Interventions:   Biological: Apolipoprotein A-I [human] (apoA-I);   Other: Placebo
  Sponsor:   CSL Behring
  Recruiting
• S1501 Carvedilol in Preventing Cardiac Toxicity in Patients With Metastatic HER-2-Positive Breast Cancer

  NCT03418961

  Conditions:   Cardiotoxicity;   HER2/Neu Positive;   Metastatic Malignant Neoplasm in the Brain;   Recurrent Breast Carcinoma;   Stage IV Breast Cancer AJCC v6 and v7
  Interventions:   Drug: Carvedilol;   Other: Laboratory Biomarker Analysis;   Other: Patient Observation
  Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• Hypofractionated Radiation Therapy After Mastectomy in Preventing Recurrence in Patients With Stage IIa-IIIa Breast Cancer

  NCT03414970

  Conditions:   Ductal Breast Carcinoma;   Invasive Breast Carcinoma;   Lobular Breast Carcinoma;   Medullary Breast Carcinoma;   Stage II Breast Cancer;   Stage IIA Breast Cancer;   Stage IIB Breast Cancer;   Stage IIIA Breast Cancer;   Tubular Breast Carcinoma
  Interventions:   Radiation: Radiation Therapy;   Other: Questionnaire Administration;   Other: Quality-of-Life Assessment;   Other: Laboratory Biomarker Analysis;   Radiation: Hypofractionated Radiation Therapy
  Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI);   Canadian Cancer Trials Group
  Recruiting
• Cabozantinib S-malate in Treating Patients With Neuroendocrine Tumors Previously Treated With Everolimus That Are Locally Advanced, Metastatic, or Cannot Be Removed by Surgery

  NCT03375320

  Conditions:   Atypical Carcinoid Tumor;   Carcinoid Tumor;   Digestive System Neuroendocrine Neoplasm;   Functioning Pancreatic Neuroendocrine Tumor;   Intermediate Grade Lung Neuroendocrine Neoplasm;   Low Grade Lung Neuroendocrine Neoplasm;   Lung Atypical Carcinoid Tumor;   Lung Carcinoid Tumor;   Metastatic Digestive System Neuroendocrine Tumor G1;   Neuroendocrine Neoplasm;   Non-Functioning Pancreatic Neuroendocrine Tumor;   Pancreatic Neuroendocrine Tumor;   Serotonin-Producing Pancreatic Neuroendocrine Tumor;   Stage IIIA Digestive System Neuroendocrine Tumor AJCC v7;   Stage IIIB Digestive System Neuroendocrine Tumor AJCC v7;   Stage IV Digestive System Neuroendocrine Tumor AJCC v7
  Interventions:   Drug: Cabozantinib S-malate;   Other: Laboratory Biomarker Analysis;   Other: Placebo;   Other: Quality-of-Life Assessment
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• BIOMARKER TRIAL of APALUTAMIDE and RADIATION for RECURRENT PROSTATE CANCER

  NCT03371719

  Conditions:   PSA Progression;   Stage III Prostate Adenocarcinoma;   Stage IV Prostate Adenocarcinoma
  Interventions:   Drug: Apalutamide;   Radiation: External Beam Radiation Therapy;   Other: Placebo
  Sponsors:   NRG Oncology;   National Cancer Institute (NCI)
  Recruiting
• Javelin Parp Medley: Avelumab Plus Talazoparib In Locally Advanced Or Metastatic Solid Tumors

  NCT03330405

  Condition:   Avelumab in Combination With Talazoparib Will be Investigated in Patients With Locally Advanced (Primary or Recurrent) or Metastatic Solid Tumors
  Interventions:   Drug: Avelumab Phase 1b;   Drug: Talazoparib Phase 1b;   Drug: Avelumab Phase 2;   Drug: Talazoparib Phase 2
  Sponsor:   Pfizer
  Recruiting
• Pembrolizumab With or Without Stereotactic Body Radiation Therapy in Treating Patients With Advanced or Metastatic Merkel Cell Cancer

  NCT03304639

  Conditions:   Stage III Merkel Cell Carcinoma AJCC v7;   Stage IIIA Merkel Cell Carcinoma AJCC v7;   Stage IIIB Merkel Cell Carcinoma AJCC v7;   Stage IV Merkel Cell Carcinoma AJCC v7
  Interventions:   Biological: Pembrolizumab;   Radiation: Stereotactic Body Radiation Therapy
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Pembrolizumab in Treating Patients With Locally Advanced Bladder Cancer

  NCT03244384

  Conditions:   Stage II Bladder Urothelial Carcinoma AJCC v6 and v7;   Stage III Bladder Urothelial Carcinoma AJCC v6 and v7
  Interventions:   Other: Clinical Observation;   Other: Laboratory Biomarker Analysis;   Biological: Pembrolizumab;   Other: Pharmacological Study;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Nivolumab After Combined Modality Therapy in Treating Patients With High Risk Stage II-IIIB Anal Cancer

  NCT03233711

  Conditions:   Anal Basaloid Carcinoma;   Anal Canal Cloacogenic Carcinoma;   Anal Margin Squamous Cell Carcinoma;   Stage IIB Anal Cancer AJCC v8;   Stage IIIA Anal Cancer AJCC v8;   Stage IIIB Anal Cancer AJCC v8;   Stage IIIC Anal Cancer AJCC v8
  Interventions:   Biological: Nivolumab;   Other: Patient Observation
  Sponsors:   National Cancer Institute (NCI);   Canadian Cancer Trials Group
  Recruiting
• Vemurafenib and Cobimetinib in Treating Patients With BRAF V600E Mutation Positive Craniopharyngioma

  NCT03224767

  Conditions:   BRAF V600E Mutation Present;   Papillary Craniopharyngioma
  Interventions:   Drug: Vemurafenib;   Drug: Cobimetinib;   Other: Laboratory Biomarker Analysis;   Other: Quality-of-Life Assessment
  Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI)
  Recruiting
• Low-Dose Ibuprofen in Improving Cognitive Impairment in Patients With Non-metastatic Colorectal Cancer Receiving Chemotherapy

  NCT03186638

  Conditions:   Caregiver;   Cognitive Impairment;   Stage 0 Colorectal Cancer AJCC v6 and v7;   Stage I Colorectal Cancer AJCC v6 and v7;   Stage II Colorectal Cancer AJCC v7;   Stage IIA Colorectal Cancer AJCC v7;   Stage IIB Colorectal Cancer AJCC v7;   Stage IIC Colorectal Cancer AJCC v7;   Stage III Colorectal Cancer AJCC v7;   Stage IIIA Colorectal Cancer AJCC v7;   Stage IIIB Colorectal Cancer AJCC v7;   Stage IIIC Colorectal Cancer AJCC v7
  Interventions:   Drug: Ibuprofen;   Other: Placebo;   Other: Questionnaire Administration
  Sponsors:   Gary Morrow;   National Cancer Institute (NCI)
  Recruiting
• Bupropion Hydrochloride in Improving Sexual Desire in Women With Breast or Gynecologic Cancer

  NCT03180294

  Conditions:   Breast Carcinoma;   Cervical Carcinoma;   Ovarian Carcinoma;   Postmenopausal;   Uterine Corpus Cancer;   Vaginal Carcinoma;   Vulvar Carcinoma
  Interventions:   Drug: Bupropion Hydrochloride;   Other: Placebo
  Sponsors:   NRG Oncology;   National Cancer Institute (NCI)
  Recruiting
• Profiling Biospecimens From Cancer Patients to Screen for Molecular Alterations Related to Treatment Selection

  NCT03061305

  Conditions:   Cancer;   Adult Solid Tumor;   Lymphoma
  Intervention:  
  Sponsor:   Strata Oncology
  Recruiting
• Stepped-Care Telehealth for Distress in Rural Cancer Survivors

  NCT03060096

  Conditions:   Anxiety;   Depressive Symptoms;   Sleep Disturbance;   Recurrent Disease;   Fatigue;   Quality of Life;   Cancer
  Interventions:   Other: Severe Anxiety/depression: High Intensity Stepped Care;   Other: Moderate Anxiety/depression: Low Intensity Stepped care;   Other: Enhanced Usual Care Control
  Sponsors:   Wake Forest University Health Sciences;   National Cancer Institute (NCI)
  Recruiting
• Ipilimumab With or Without Nivolumab in Treating Patients With Melanoma That Is Stage IV or Stage III and Cannot Be Removed by Surgery

  NCT03033576

  Conditions:   Advanced Melanoma;   Melanoma of Unknown Primary;   Mucosal Melanoma;   Refractory Melanoma;   Stage III Cutaneous Melanoma AJCC v7;   Stage IIIA Cutaneous Melanoma AJCC v7;   Stage IIIB Cutaneous Melanoma AJCC v7;   Stage IIIC Cutaneous Melanoma AJCC v7;   Stage IV Cutaneous Melanoma AJCC v6 and v7;   Unresectable Cutaneous Melanoma;   Unresectable Melanoma
  Interventions:   Biological: Ipilimumab;   Biological: Nivolumab
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• A Study of Rucaparib Versus Physician's Choice of Therapy in Patients With Metastatic Castration-resistant Prostate Cancer and Homologous Recombination Gene Deficiency

  NCT02975934

  Condition:   Metastatic Castration Resistant Prostate Cancer
  Interventions:   Drug: Rucaparib;   Drug: Abiraterone acetate or Enzalutamide or Docetaxel
  Sponsors:   Clovis Oncology, Inc.;   Foundation Medicine
  Recruiting
• Pembrolizumab in Treating Patients With Triple-Negative Breast Cancer

  NCT02954874

  Conditions:   Invasive Breast Carcinoma;   Stage 0 Breast Cancer AJCC v6 and v7;   Stage I Breast Cancer AJCC v7;   Stage IA Breast Cancer AJCC v7;   Stage IB Breast Cancer AJCC v7;   Stage II Breast Cancer AJCC v6 and v7;   Stage IIA Breast Cancer AJCC v6 and v7;   Stage IIB Breast Cancer AJCC v6 and v7;   Stage III Breast Cancer AJCC v7;   Stage IIIA Breast Cancer AJCC v7;   Stage IIIB Breast Cancer AJCC v7;   Stage IIIC Breast Cancer AJCC v7;   Triple-Negative Breast Carcinoma
  Interventions:   Other: Laboratory Biomarker Analysis;   Other: Patient Observation;   Biological: Pembrolizumab;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration;   Radiation: Radiation Therapy
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Aspirin in Preventing Recurrence of Cancer in Patients With HER2 Negative Stage II-III Breast Cancer After Chemotherapy, Surgery, and/or Radiation Therapy

  NCT02927249

  Condition:   Node Positive HER2 Negative Breast Cancer
  Interventions:   Other: Placebo;   Drug: Aspirin
  Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI);   United States Department of Defense;   Bayer;   Canadian Cancer Trials Group
  Recruiting
• Nivolumab and Ipilimumab in Treating Patients With Rare Tumors

  NCT02834013

  Conditions:   Acinar Cell Carcinoma;   Adenoid Cystic Carcinoma;   Adrenal Cortex Carcinoma;   Adrenal Gland Pheochromocytoma;   Anal Canal Neuroendocrine Carcinoma;   Anal Canal Undifferentiated Carcinoma;   Angiosarcoma;   Apocrine Neoplasm;   Appendix Mucinous Adenocarcinoma;   Bartholin Gland Transitional Cell Carcinoma;   Basal Cell Carcinoma;   Bladder Adenocarcinoma;   Cervical Adenocarcinoma;   Cervical Clear Cell Adenocarcinoma;   Cholangiocarcinoma;   Chordoma;   Colorectal Squamous Cell Carcinoma;   Desmoid-Type Fibromatosis;   Endometrial Transitional Cell Carcinoma;   Endometrioid Adenocarcinoma;   Esophageal Neuroendocrine Carcinoma;   Esophageal Undifferentiated Carcinoma;   Extrahepatic Bile Duct Carcinoma;   Extramammary Paget Disease;   Fallopian Tube Adenocarcinoma;   Fallopian Tube Transitional Cell Carcinoma;   Fibromyxoid Tumor;   Gallbladder Carcinoma;   Gastric Neuroendocrine Carcinoma;   Gastric Squamous Cell Carcinoma;   Gastric Undifferentiated Carcinoma;   Gastrointestinal Stromal Tumor;   Gestational Trophoblastic Tumor;   Giant Cell Carcinoma;   Intestinal Neuroendocrine Carcinoma;   Intrahepatic Cholangiocarcinoma;   Lung Carcinoid Tumor;   Lung Sarcomatoid Carcinoma;   Major Salivary Gland Carcinoma;   Malignant Odontogenic Neoplasm;   Malignant Peripheral Nerve Sheath Tumor;   Malignant Testicular Sex Cord-Stromal Tumor;   Metaplastic Breast Carcinoma;   Metastatic Malignant Neoplasm of Unknown Primary;   Minimally Invasive Lung Adenocarcinoma;   Mixed Mesodermal (Mullerian) Tumor;   Mucinous Adenocarcinoma;   Mucinous Cystadenocarcinoma;   Nasal Cavity Adenocarcinoma;   Nasal Cavity Carcinoma;   Nasopharyngeal Carcinoma;   Nasopharyngeal Papillary Adenocarcinoma;   Nasopharyngeal Undifferentiated Carcinoma;   Oral Cavity Carcinoma;   Oropharyngeal Undifferentiated Carcinoma;   Ovarian Adenocarcinoma;   Ovarian Clear Cell Adenocarcinoma;   Ovarian Germ Cell Tumor;   Ovarian Mucinous Adenocarcinoma;   Ovarian Squamous Cell Carcinoma;   Ovarian Transitional Cell Carcinoma;   Pancreatic Acinar Cell Carcinoma;   Pancreatic Neuroendocrine Carcinoma;   Paraganglioma;   Paranasal Sinus Adenocarcinoma;   Paranasal Sinus Carcinoma;   Parathyroid Gland Carcinoma;   PEComa;   Peritoneal Mesothelioma;   Pituitary Gland Carcinoma;   Placental Choriocarcinoma;   Primary Peritoneal High Grade Serous Adenocarcinoma;   Pseudomyxoma Peritonei;   Rare Disorder;   Scrotal Squamous Cell Carcinoma;   Seminal Vesicle Adenocarcinoma;   Seminoma;   Serous Cystadenocarcinoma;   Small Intestinal Adenocarcinoma;   Small Intestinal Squamous Cell Carcinoma;   Solid Neoplasm;   Spindle Cell Neoplasm;   Squamous Cell Carcinoma of the Penis;   Teratoma With Somatic-Type Malignancy;   Testicular Non-Seminomatous Germ Cell Tumor;   Thyroid Gland Carcinoma;   Tracheal Carcinoma;   Transitional Cell Carcinoma;   Ureter Adenocarcinoma;   Ureter Squamous Cell Carcinoma;   Urethral Adenocarcinoma;   Urethral Squamous Cell Carcinoma;   Vaginal Adenocarcinoma;   Vaginal Squamous Cell Carcinoma, Not Otherwise Specified;   Vulvar Carcinoma
  Interventions:   Procedure: Biospecimen Collection;   Biological: Ipilimumab;   Biological: Nivolumab
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Phase 3 Randomized Placebo Controlled Clinical Trial of Donepezil

  NCT02822573

  Conditions:   Cognitive Dysfunction;   Memory Impairment
  Interventions:   Drug: Donepezil 5 mg;   Drug: Placebo
  Sponsors:   Wake Forest University Health Sciences;   National Cancer Institute (NCI)
  Recruiting
• Pembrolizumab in Treating Patients With Desmoplastic Melanoma That Can or Cannot Be Removed by Surgery

  NCT02775851

  Condition:   Desmoplastic Melanoma
  Interventions:   Biological: Pembrolizumab;   Procedure: Therapeutic Conventional Surgery
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Cabozantinib S-Malate, Crizotinib, Savolitinib, or Sunitinib Malate in Treating Patients With Locally Advanced or Metastatic Kidney Cancer

  NCT02761057

  Conditions:   Stage III Renal Cell Cancer AJCC v7;   Stage IV Renal Cell Cancer AJCC v7;   Type 1 Papillary Renal Cell Carcinoma;   Type 2 Papillary Renal Cell Carcinoma;   Unresectable Renal Cell Carcinoma
  Interventions:   Drug: Cabozantinib;   Drug: Cabozantinib S-malate;   Drug: Crizotinib;   Drug: Savolitinib;   Drug: Sunitinib;   Drug: Sunitinib Malate
  Sponsors:   National Cancer Institute (NCI);   Canadian Cancer Trials Group
  Recruiting
• Breast Cancer WEight Loss Study (BWEL Study)

  NCT02750826

  Condition:   Breast Carcinoma
  Interventions:   Other: Health Education Program;   Other: Weight Loss Intervention
  Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI);   Division of Cancer Control;   NIH Biomarker, Imaging and Quality of Life Studies Funding Program (BIQSFP);   Canadian Cancer Trials Group
  Recruiting
• Direct Oral Anticoagulants (DOACs) Versus LMWH +/- Warfarin for VTE in Cancer

  NCT02744092

  Conditions:   Cancer;   Venous Thromboembolism;   Deep Vein Thrombosis (DVT);   Pulmonary Embolism (PE);   Blood Clot
  Interventions:   Drug: Rivaroxaban;   Drug: Apixaban;   Drug: Edoxaban;   Drug: Dabigatran;   Drug: Warfarin;   Drug: Dalteparin;   Drug: Enoxaparin;   Drug: Fondaparinux
  Sponsors:   Alliance Foundation Trials, LLC.;   Patient-Centered Outcomes Research Institute
  Recruiting
• Doxorubicin Hydrochloride and Cyclophosphamide Followed by Paclitaxel With or Without Carboplatin in Treating Patients With Triple-Negative Breast Cancer

  NCT02488967

  Conditions:   Breast Adenocarcinoma;   Estrogen Receptor Negative;   HER2/Neu Negative;   Progesterone Receptor Negative;   Stage IB Breast Cancer;   Stage IIA Breast Cancer;   Stage IIB Breast Cancer;   Stage IIIA Breast Cancer;   Stage IIIC Breast Cancer;   Triple-Negative Breast Carcinoma
  Interventions:   Drug: Carboplatin;   Drug: Cyclophosphamide;   Drug: Doxorubicin Hydrochloride;   Other: Laboratory Biomarker Analysis;   Drug: Paclitaxel
  Sponsors:   NRG Oncology;   National Cancer Institute (NCI)
  Recruiting