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• Improving Safety of Transitions to Skilled Nursing Care Using Videoconferencing

  NCT03832257

  Condition:   Acute Disease
  Interventions:   Other: ECHO CT Intervention;   Other: Matched Non-Participating Facilities
  Sponsors:   Beth Israel Deaconess Medical Center;   Brown University;   Hebrew SeniorLife
  Recruiting
• A Geriatric Oncology Collaborative Care Intervention for Older Adults With Advanced Cancer

  NCT03721926

  Condition:   Other Cancer
  Interventions:   Other: Usual Care;   Other: Geriatric Oncology Collaborative Care
  Sponsors:   Massachusetts General Hospital;   National Cancer Institute (NCI)
  Recruiting
• Elevate! : An Elderly Breast Cancer Cohort Study

  NCT03818087

  Condition:   Breast Cancer
  Intervention:   Behavioral: Observational cohort
  Sponsors:   Dana-Farber Cancer Institute;   Susan G. Komen Breast Cancer Foundation
  Recruiting
• Discussing Stopping Cancer Screening and Prognosis With Older Adults

  NCT03480282

  Condition:   Cancer Screening
  Intervention:   Other: Prognosis information and Provider Scripts
  Sponsor:   Beth Israel Deaconess Medical Center
  Recruiting
• Is There an Alternative to Immediate Home Physical Therapy Following Total Knee Arthroplasty

  NCT04060251

  Condition:   Total Knee Arthroplasty
  Interventions:   Device: CyMedica e-vive™ System; CY-1000;   Other: iGetBetter telemedicine physical therapy
  Sponsors:   Wolfgang Fitz, M.D.;   CyMedica Orthopedics, Inc
  Recruiting
• Mechanism of Action of Electroconvulsive Therapy

  NCT04059952

  Conditions:   Unipolar Depression;   Bipolar Depression
  Intervention:   Procedure: Electroconvulsive Therapy
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Netarsudil Use After Descemetorhexis Without Endothelial Keratoplasty

  NCT04057053

  Conditions:   Fuchs' Endothelial Dystrophy;   Cataract
  Intervention:   Drug: Netarsudil 0.02% Ophthalmic Solution
  Sponsor:   Massachusetts Eye and Ear Infirmary
  Recruiting
• Neurological Impacts of Artificial Sweeteners in the Context of Diet Sodas

  NCT04048681

  Condition:   Obesity
  Interventions:   Behavioral: diet soda;   Behavioral: Regular soda;   Behavioral: Carbonated Water
  Sponsor:   Beth Israel Deaconess Medical Center
  Recruiting
• Integrating Mind Body Skills and Physical Activity in Older Adults With Mild Cognitive Impairment (MCI) and Chronic Pain

  NCT04044183

  Conditions:   Chronic Pain;   Mild Cognitive Impairment;   Older Adults;   Physical Activity
  Interventions:   Behavioral: Active Brains;   Behavioral: Active Brains with Fitbit
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Mind Body Therapy for the Treatment of Chronic Pain

  NCT04039139

  Conditions:   Chronic Pain;   Chronic Pain Syndrome
  Interventions:   Behavioral: Mind Body Intervention 1;   Behavioral: Mind Body Intervention 2
  Sponsor:   Beth Israel Deaconess Medical Center
  Recruiting
• Effect of Dried Fruit Intake on Acid-base Balance

  NCT04030351

  Condition:   Acid-Base Balance Disorder
  Intervention:   Other: food - dried fruit
  Sponsors:   Tufts University;   Tufts Medical Center
  Recruiting
• Understanding Chronic Lymphocytic Leukemia

  NCT04028531

  Condition:   Chronic Lymphocytic Leukemia
  Intervention:  
  Sponsors:   Dana-Farber Cancer Institute;   National Cancer Institute (NCI)
  Recruiting
• PET Fibrin Imaging of DVT and PE

  NCT04022915

  Conditions:   Pulmonary Embolism;   Deep Vein Thrombosis;   Venous Thromboembolism
  Interventions:   Drug: 64Cu-FBP8;   Diagnostic Test: PET-CT imaging
  Sponsors:   Peter David Caravan;   National Heart, Lung, and Blood Institute (NHLBI)
  Recruiting
• H+ Mobilization With Dialysate Bicarbonate Variation

  NCT04020757

  Condition:   Chronic Kidney Disease
  Interventions:   Device: variation in dialysis bicarbonate;   Dietary Supplement: Zone Perfect bar
  Sponsors:   Tufts Medical Center;   Dialysis Clinic, Inc.
  Recruiting
• Dietary Restriction in Vascular Surgery

  NCT04013412

  Conditions:   Vascular Diseases;   Surgery
  Intervention:   Dietary Supplement: Protein-Calorie Restriction
  Sponsor:   Brigham and Women's Hospital
  Recruiting
• PREDICT 2: Personalized Responses to Dietary Composition Trial 2

  NCT03983733

  Conditions:   Diabetes;   Heart Diseases;   Diet Habit;   Diet Modification;   Microbial Colonization;   Healthy;   Obesity;   Metabolism
  Intervention:   Other: Dietary Intervention
  Sponsors:   Zoe Global Limited;   Massachusetts General Hospital;   Stanford University;   King's College London;   Tufts University
  Recruiting
• Internet-based Videoconferencing to Address Alcohol Use and Pain

  NCT03982433

  Conditions:   Chronic Pain;   Alcohol Use, Unspecified
  Intervention:   Behavioral: Motivation and Cognitive Behavioral Management for Alcohol and Pain
  Sponsors:   Boston University Charles River Campus;   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
  Recruiting
• A Pilot Study of Quantitative Tumor Oxygen Measurements in Cervical Cancer

  NCT03970083

  Conditions:   Gynecologic Cancer;   Cervical Cancer
  Intervention:  
  Sponsor:   Dana-Farber Cancer Institute
  Recruiting
• Multimodal Mobile Intervention Application (App) to Address Sexual Dysfunction in Hematopoietic Stem Cell Transplant Survivors

  NCT03967379

  Condition:   Other Cancer
  Interventions:   Behavioral: Mobile App + enhanced standard care;   Other: Enhanced Standard Care
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Upper Extremity Rehabilitation With the BURT Robotic Arm

  NCT03965403

  Conditions:   Stroke;   Hemiparesis
  Intervention:   Device: Arm motor function retraining with BURT
  Sponsor:   Spaulding Rehabilitation Hospital
  Recruiting
• AKT Inhibitor, Ipatasertib, With Endocrine and CDK 4/6 Inhibitor for Patients With Metastatic Breast Cancer (TAKTIC)

  NCT03959891

  Condition:   Breast Cancer
  Interventions:   Drug: Ipatasertib;   Drug: Fulvestrant;   Drug: Aromatase Inhibitor;   Drug: Palbociclib
  Sponsors:   Massachusetts General Hospital;   Genentech, Inc.
  Recruiting
• Version 2 of the Smoking Cessation Smartphone App "Smiling Instead of Smoking" (SiS)

  NCT03951766

  Conditions:   Smoking Cessation;   Smoking, Tobacco
  Intervention:   Behavioral: Smiling Instead of Smoking (SiS) App Version 2
  Sponsors:   Massachusetts General Hospital;   American Cancer Society, Inc.
  Recruiting
• Real-time Intervention for Suicide Risk Reduction

  NCT03950765

  Conditions:   Suicide, Attempted;   Suicide and Self-harm
  Intervention:   Behavioral: Ecological momentary intervention
  Sponsors:   Harvard University;   National Institute of Mental Health (NIMH);   Massachusetts General Hospital
  Recruiting
• Body Composition Ultrasound for Patients With Heart Failure

  NCT03948776

  Condition:   Heart Failure
  Interventions:   Diagnostic Test: BodyMetrix body composition ultrasound;   Diagnostic Test: BodyMetrix body composition ultrasound only
  Sponsor:   Tufts Medical Center
  Recruiting
• Global Atrophie Biomarker Evaluation Study (GABiE)

  NCT03935126

  Condition:   Age-related Macular Degeneration
  Intervention:   Diagnostic Test: Diagnostics
  Sponsor:   Boehringer Ingelheim
  Recruiting
• 3D Printer Modified CPAP Mask for Obstructive Sleep Apnea

  NCT03932383

  Condition:   Obstructive Sleep Apnea
  Intervention:   Device: Custom CPAP mask
  Sponsor:   Beth Israel Deaconess Medical Center
  Recruiting
• A Novel Pharmacological Therapy for Obstructive Sleep Apnea

  NCT03919955

  Condition:   Sleep Apnea
  Interventions:   Drug: Atomoxetine;   Drug: Oxybutynin;   Drug: Placebo
  Sponsor:   Brigham and Women's Hospital
  Recruiting
• Addressing Disparities in Lupus Care Through an Integrated Care Management Program

  NCT03915652

  Condition:   Systemic Lupus Erythematosus
  Intervention:   Behavioral: Rheum iCMP
  Sponsors:   Brigham and Women's Hospital;   Partners HealthCare
  Recruiting
• Acceptance and Commitment Therapy (ACT) - Based Treatment Development for Cancer Patients Treated for Pain

  NCT03910296

  Condition:   Cancer
  Intervention:   Behavioral: Acceptance & Commitment Therapy
  Sponsor:   Dana-Farber Cancer Institute
  Recruiting
• Arthroscopic Labral Repair Versus Physical Therapy for Tears of the Acetabular Labrum

  NCT03909178

  Conditions:   Acetabular Labrum Tear;   Femoro Acetabular Impingement;   Hip Arthroscopy;   Physical Therapy;   Osteoarthritis, Hip
  Interventions:   Procedure: Hip Arthroscopy Surgery with Acetabular Labral Repair;   Procedure: Physical Therapy Focused on the Hip and Hemi-pelvis
  Sponsor:   Massachusetts General Hospital
  Recruiting
• BMAC Use With Labral Repair

  NCT03909139

  Conditions:   Acetabular Labrum Tear;   Pincer Lesion;   Femoro Acetabular Impingement;   Chondral Defect;   Bone Marrow Aspirate Concentrate;   Mesenchymal Stem Cell
  Intervention:   Biological: BMAC
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Safety, Tolerability and Potential Efficacy of AVT001 in Patients With Type 1 Diabetes

  NCT03895996

  Condition:   Type 1 Diabetes Mellitus
  Interventions:   Drug: AVT001;   Other: Placebo
  Sponsor:   Avotres Inc.
  Recruiting
• Mental Training for Adults With Mild Cognitive Impairment

  NCT03895346

  Conditions:   Mild Cognitive Impairment;   Aging
  Interventions:   Behavioral: Mindfulness;   Behavioral: Brain Games and Puzzles
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Induction TPN Followed by Nivolumab With Radiation in Locoregionally Advanced Laryngeal and Hypopharyngeal Cancer

  NCT03894891

  Condition:   Head and Neck Cancer
  Interventions:   Drug: Nivolumab;   Drug: Cisplatin;   Drug: Docetaxel;   Radiation: Radioimmunotherapy
  Sponsors:   Dana-Farber Cancer Institute;   Bristol-Myers Squibb
  Recruiting
• Combination Pharmacological Interventions for Multiple Mechanisms of Obstructive Sleep Apnea

  NCT03892772

  Condition:   Sleep Apnea
  Interventions:   Drug: SAS0421a;   Drug: SAS0421b;   Drug: SAS0421c;   Drug: SAS0421d;   Drug: placebo
  Sponsor:   Brigham and Women's Hospital
  Recruiting
• Investigation of Cannabidiol for Reduction of NeuroInflammation in Chronic Back Pain

  NCT03891264

  Condition:   Back Pain, Low
  Intervention:   Drug: Cannabidiol
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Incidence and Nature of Respiratory Impairment in Consecutive Patients Undergoing Bronchoscopy Under Conscious Sedation: A Pilot Study

  NCT03886454

  Conditions:   Conscious Sedation;   Bronchoscopy
  Intervention:  
  Sponsors:   Tufts Medical Center;   Natalie V. Zucker Research Grant
  Recruiting
• Investigation of 2X-121 in Patients With Advanced Ovarian Cancer Selected by the 2X-121 DRP®

  NCT03878849

  Condition:   Advanced Ovarian Cancer
  Interventions:   Drug: 2X-121;   Device: 2X-121 DRP®
  Sponsors:   Oncology Venture;   Alcedis GmbH;   Amarex Clinical Research
  Recruiting
• MBCT Delivered Via Group Videoconferencing for ACS Patients With Elevated Depression Symptoms

  NCT03878160

  Conditions:   Acute Coronary Syndrome;   Depression;   Myocardial Infarction;   Unstable Angina;   STEMI;   NSTEMI - Non-ST Segment Elevation MI
  Interventions:   Other: Focus Group;   Other: Individual Interview
  Sponsors:   Massachusetts General Hospital;   National Center for Complementary and Integrative Health (NCCIH)
  Recruiting
• Clinical Pre-screening Protocol for Ovarian Cancer

  NCT03877796

  Condition:   Ovarian Cancer
  Intervention:   Device: Drug Response Predictor® (DRP)
  Sponsors:   Oncology Venture;   Amarex Clinical Research
  Recruiting
• Study of Postoperative Radiation Therapy for HPV Associated Oropharyngeal Squamous Cell Carcinoma

  NCT03875716

  Condition:   Head and Neck Cancer
  Intervention:   Radiation: Radiation therapy
  Sponsor:   Dana-Farber Cancer Institute
  Recruiting
• Food Talk: A New App for Daily Food Monitoring

  NCT03869658

  Condition:   Dietary Intake
  Intervention:   Behavioral: COCO application
  Sponsors:   Tufts University;   Massachusetts Institute of Technology
  Recruiting
• Low Intensity Focused Ultrasound Treatment for Drug-Resistant Epilepsy: An Efficacy Trial

  NCT03868293

  Condition:   Drug Resistant Epilepsy
  Intervention:   Device: Focused ultrasound
  Sponsor:   Brigham and Women's Hospital
  Recruiting
• Growing Together: Women in Opioid Treatment and Their Infants

  NCT03866694

  Condition:   Substance-Related Disorders
  Interventions:   Behavioral: BRIGHT;   Other: STAR/TAU+
  Sponsors:   Boston University Charles River Campus;   Health Resources and Services Administration (HRSA);   Institute for Health and Recovery (IHR);   Boston University;   Boston University School of Social Work
  Recruiting
• Characterizing the Electroencephalogram Signature of Fentanyl During Induction of General Anesthesia

  NCT03866278

  Condition:   Anesthesia
  Intervention:  
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Exploring the Efficacy and Feasibility of the LymphaTech Scanner for Breast Cancer-Related Lymphedema Screening

  NCT03861975

  Condition:   Breast Cancer
  Intervention:  
  Sponsors:   Massachusetts General Hospital;   Heinz Family Foundation
  Recruiting
• Impact of Metabolic Health on Sperm Epigenetic Marks in Humans

  NCT03860558

  Conditions:   Overweight;   Type 2 Diabetes Mellitus;   Type 1 Diabetes Mellitus
  Interventions:   Other: Lifestyle Intervention;   Other: No Intervention
  Sponsor:   Joslin Diabetes Center
  Recruiting
• Pharmacological Activation of HMN for OSA Aim 2

  NCT03858751

  Condition:   Obstructive Sleep Apnea
  Interventions:   Drug: Placebo oral capsule;   Drug: LTM1201AZ;   Drug: LTM1201AT;   Drug: LTM1201AG;   Drug: LTM1201AD
  Sponsor:   Brigham and Women's Hospital
  Recruiting
• EHR-embedded OCDT in Breast or GI Cancer

  NCT03858712

  Conditions:   Oral Cancer Directed Therapy;   Breast Cancer;   Gastrointestinal Cancer;   Oral Chemotherapy
  Interventions:   Other: Active Care Team Alert;   Other: Passive Care Team Alert
  Sponsor:   Dana-Farber Cancer Institute
  Recruiting
• Nutrition Status of Adults With PKU Before and During Treatment With Pegvaliase

  NCT03856203

  Condition:   Phenylketonurias
  Intervention:  
  Sponsors:   Boston Children’s Hospital;   BioMarin Pharmaceutical
  Recruiting
• Wellness Tool in Anesthesia Providers

  NCT03844308

  Conditions:   Burnout, Professional;   Occupational Stress;   Affective Symptoms
  Intervention:   Behavioral: Isha Kriya Meditation
  Sponsor:   Beth Israel Deaconess Medical Center
  Recruiting
• Feasibility of the LUM Imaging System for Peritoneal Surface Malignancies

  NCT03834272

  Condition:   Peritoneal Metastases
  Intervention:   Combination Product: LUM Imaging System
  Sponsor:   Lumicell, Inc.
  Recruiting
• Growth Hormone Dynamics and Cardiac Steatosis in HIV

  NCT03826160

  Conditions:   Human Immunodeficiency Virus;   Lipodystrophy;   Cardiac Disease
  Intervention:  
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Yoga for Painful Chemotherapy-Induced Peripheral Neuropathy: A Pilot, Randomized-Controlled Study

  NCT03824860

  Conditions:   Chemotherapy-induced Peripheral Neuropathy;   Yoga;   Chronic Pain;   Neuropathic Pain
  Intervention:   Behavioral: Yoga
  Sponsors:   Dana-Farber Cancer Institute;   Oncology Nursing Foundation
  Recruiting
• Exercise Training to Improve Cognitive Function

  NCT03824639

  Condition:   Mild Cognitive Impairment
  Interventions:   Behavioral: Structured exercise;   Behavioral: Health Education
  Sponsor:   VA Office of Research and Development
  Recruiting
• The Use of Virtual Reality for Lumbar Pain Management in an Outpatient Spine Clinic

  NCT03819907

  Condition:   Chronic Low Back Pain
  Interventions:   Combination Product: Audiovisual Guided Relaxation;   Combination Product: Virtual Reality Guided Relaxation
  Sponsor:   Spaulding Rehabilitation Hospital
  Recruiting
• Suvorexant on Sleep Disturbance in Patients With Chronic Insomnia and Suboptimally Controlled Type 2 Diabetes

  NCT03818581

  Conditions:   Type 2 Diabetes Mellitus;   Insomnia;   Sleep Disorder;   Inflammation
  Interventions:   Drug: Suvorexant;   Other: Placebo
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Implementing a Virtual Tobacco Treatment for Cancer Patients in Community Oncology Practices

  NCT03808818

  Conditions:   Carcinoma In Situ;   Current Smoker;   Malignant Neoplasm;   Primary Neoplasm;   Recurrent Neoplasm
  Interventions:   Other: Behavioral, Psychological or Informational Intervention;   Drug: Nicotine Replacement;   Other: Quality-of-Life Assessment;   Other: Survey Administration;   Other: Tobacco Cessation Counseling
  Sponsors:   ECOG-ACRIN Cancer Research Group;   National Cancer Institute (NCI)
  Recruiting
• Multimodal Sexual Dysfunction Intervention In HCT

  NCT03803696

  Conditions:   Hematopoietic Stem Cell Transplantation;   Hematologic Diseases;   Sexual Dysfunction
  Interventions:   Behavioral: Enhanced Standard Care;   Behavioral: Multimodal Intervention to Address Sexual Dysfunction
  Sponsors:   Massachusetts General Hospital;   American Cancer Society, Inc.
  Recruiting
• Nutrition Status of Adults Treated With Pegvaliase

  NCT03792451

  Condition:   Phenylketonurias
  Intervention:   Drug: Pegvaliase
  Sponsors:   Boston Children’s Hospital;   BioMarin Pharmaceutical
  Recruiting
• Secukinumab for NLD (Cosentyx) in Patients With Necrobiosis Lipoidica Diabeticorum (NLD)

  NCT03791060

  Condition:   Necrobiosis Lipoidica Diabeticorum
  Intervention:   Drug: Secukinumab
  Sponsors:   Beth Israel Deaconess Medical Center;   Novartis Pharmaceuticals
  Recruiting
• NIMBUS: Nivolumab Plus Ipilimumab in Metastatic Hypermutated HER2-negative Breast Cancer

  NCT03789110

  Condition:   Breast Cancer
  Interventions:   Drug: Nivolumab;   Drug: Ipilimumab
  Sponsors:   Dana-Farber Cancer Institute;   Bristol-Myers Squibb
  Recruiting
• Dendritic Cell (DC)/Myeloma Fusions in Combination With Nivolumab in Patients With Relapsed Multiple Myeloma

  NCT03782064

  Condition:   Multiple Myeloma
  Interventions:   Drug: Nivolumab;   Biological: DC/myeloma fusions/GM-CSF
  Sponsors:   Dana-Farber Cancer Institute;   Bristol-Myers Squibb
  Recruiting
• A Virtual Reality Study of Cognitive Biases in Body Dysmorphic Disorder

  NCT03773549

  Conditions:   Body Dysmorphic Disorders;   Healthy
  Intervention:   Other: Virtual reality experience
  Sponsor:   Massachusetts General Hospital
  Recruiting
• GENetic Education Risk Assessment and TEsting Study

  NCT03762590

  Condition:   Candidates for Hereditary Pancreatic Cancer Testing
  Interventions:   Other: Doxy.me genetic education +/- Color Genomics genetic education;   Other: Color Genomics genetic education
  Sponsors:   Dana-Farber Cancer Institute;   M.D. Anderson Cancer Center;   Johns Hopkins University;   University of California, San Diego;   Mayo Clinic;   Weill Cornell Medicine;   Stand Up To Cancer;   Lustgarten Foundation
  Recruiting
• A Study of Technology to Improve Glucose Control in Participants With Type 1 Diabetes

  NCT03758430

  Condition:   Diabetes Mellitus, Type 1
  Interventions:   Other: Meal-Tagging App;   Device: Fitness Tracker
  Sponsors:   Eli Lilly and Company;   Joslin Diabetes Center
  Recruiting
• ENGAGE for Brain Health

  NCT03750682

  Condition:   Motoric Cognitive Risk Syndrome
  Interventions:   Other: Physical Activity (PA) Intervention;   Other: Healthy Aging Education (HE) Intervention
  Sponsors:   Tufts University;   Boston Older Americans Independence Center;   Somerville Council on Aging, Massachusetts
  Recruiting
• Prospective Study of the Prosigna Assay on Neoadjuvant Clinical Decision-making in Women With HR+/Her2- Breast Cancer

  NCT03749421

  Condition:   Breast Cancer
  Intervention:   Other: Prosigna PAM-50 assay
  Sponsors:   Dana-Farber Cancer Institute;   NanoString Technologies, Inc.
  Recruiting
• Acute Raspberry Intake on Metabolic Control and Cognitive Function

  NCT03743792

  Conditions:   Aging;   Age-related Cognitive Decline;   Obesity
  Interventions:   Dietary Supplement: Active breakfast;   Dietary Supplement: Control breakfast
  Sponsor:   USDA Human Nutrition Research Center on Aging
  Recruiting
• Psychological Intervention for Caregivers of Patients With Malignant Gliomas

  NCT03735498

  Condition:   Malignant Glioma
  Intervention:   Other: Psychological Intervention
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Pilot Study of Cognitive Behavioral Therapy-Informed Physical Therapy Intervention in Functional Neurological Disorders

  NCT03731078

  Condition:   Functional Neurological Disorder
  Intervention:   Other: CBT Informed physical therapy Intervention
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Computerized Decision Support to Increase Detection of Chronic Thromboembolic Pulmonary Hypertension in Patients With Prior Pulmonary Embolism

  NCT03729544

  Condition:   Chronic Thromboembolic Pulmonary Hypertension
  Intervention:   Behavioral: On-screen computerized decision support alert
  Sponsors:   Brigham and Women's Hospital;   Bayer
  Recruiting
• Computerized Decision Support for Prevention of VTE in Hospitalized Medical Patients Across the Continuum of Care (DC-eALERT)

  NCT03728166

  Condition:   Venous Thromboembolism
  Intervention:   Behavioral: Electronic alert
  Sponsors:   Brigham and Women's Hospital;   Portola Pharmaceuticals
  Recruiting
• A Phase 1/2a Study of PGT121, VRC07-523LS and PGDM1400 Monoclonal Antibodies in HIV-uninfected and HIV-infected Adults

  NCT03721510

  Condition:   HIV/AIDS
  Interventions:   Biological: PGT121 + VRC07-523LS;   Biological: PGT121 + VRC07-523LS + PGDM1400
  Sponsors:   International AIDS Vaccine Initiative;   Beth Israel Deaconess Medical Center;   Vaccine Research Center (VRC), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH)
  Recruiting
• Ex Vivo TCR αβ T Cell Depletion for Graft-Versus-Host Disease Prophylaxis in Mismatched Donor Peripheral Blood Stem Cell Transplantation for Hematologic Malignancies

  NCT03717480

  Condition:   Hematologic Malignancy
  Intervention:   Device: ClinicMACs
  Sponsor:   Dana-Farber Cancer Institute
  Recruiting
• Smartphone Technology to Alleviate Malignant Pain (STAMP)

  NCT03717402

  Conditions:   Cancer;   Pain Management;   Opioid Use
  Interventions:   Other: STAMP App;   Other: No access to STAMP App
  Sponsors:   Dana-Farber Cancer Institute;   National Institute of Nursing Research (NINR)
  Recruiting
• Feasibility of the LUM Imaging System for Detection of Cancer to the Brain

  NCT03717142

  Conditions:   Low Grade Glioma of Brain;   Glioblastoma;   Metastasis to Brain
  Intervention:   Combination Product: LUM Imaging System
  Sponsor:   Lumicell, Inc.
  Recruiting
• Electron Beam Intraoperative Radiation Therapy Following Chemoradiation in Patients With Pancreatic Cancer With Vascular Involvement

  NCT03716531

  Condition:   Pancreas Cancer
  Intervention:   Radiation: IORT
  Sponsors:   Massachusetts General Hospital;   IntraOp/Mobetron
  Recruiting
• 24 Month Open Label Study of the Tolerability and Efficacy of Inotersen in TTR Amyloid Cardiomyopathy Patients

  NCT03702829

  Condition:   Amyloidosis
  Intervention:   Drug: Inotersen
  Sponsor:   Brigham and Women's Hospital
  Recruiting
• Rivaroxaban vs. Warfarin for Post Cardiac Surgery Atrial Fibrillation

  NCT03702582

  Conditions:   Atrial Fibrillation;   Stroke;   Bleeding
  Interventions:   Drug: Rivaroxaban;   Drug: Warfarin
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Evaluation of Safety of Xeno-Skin™ for Treatment of Severe and Extensive, Partial and Full Thickness Burns

  NCT03695939

  Condition:   Burn Wound
  Intervention:   Biological: Xeno-Skin™
  Sponsors:   XenoTherapeutics, Inc.;   Massachusetts General Hospital
  Recruiting
• Developing Viability Index for Machine Perfused Livers

  NCT03694691

  Condition:   Liver Cirrhoses
  Intervention:   Diagnostic Test: Liver Biopsy
  Sponsors:   Massachusetts General Hospital;   Shriner's
  Recruiting
• Predicting Progression of Developing Myeloma in a High-Risk Screened Population (PROMISE)

  NCT03689595

  Condition:   Multiple Myeloma
  Intervention:   Other: Sample of Blood
  Sponsors:   Dana-Farber Cancer Institute;   Stand Up To Cancer
  Recruiting
• Clinical Trial to Evaluate the Efficacy of OC-01 Nasal Spray on Goblet Cell and Meibomian Gland Stimulation (The IMPERIAL Study)

  NCT03688802

  Condition:   Dry Eye Disease
  Interventions:   Drug: OC-01;   Drug: Placebo
  Sponsor:   Oyster Point Pharma, Inc.
  Recruiting
• The Digital Incentive Spirometer (DIS): Improving Adherence to Incentive Spirometry

  NCT03686631

  Conditions:   Post-Op Infection;   Adherence, Patient;   Pulmonary Atelectasis;   Incentive Spirometry;   Post-Op Complication
  Intervention:   Behavioral: Smartphone Arm
  Sponsor:   Beth Israel Deaconess Medical Center
  Recruiting
• Effect of Dupilumab on Sleep Apnea in Patients With Rhinosinusitis

  NCT03675022

  Conditions:   Sleep Apnea;   Rhinosinusitis Chronic
  Intervention:   Drug: Dupilumab
  Sponsor:   Brigham and Women's Hospital
  Recruiting
• Ruxolitinib for Bronchiolitis Obliterans Syndrome (BOS) After Allogeneic Hematopoietic Cell Transplantation (HCT)

  NCT03674047

  Condition:   Other Cancer
  Intervention:   Drug: ruxolitinib
  Sponsors:   Massachusetts General Hospital;   Incyte Corporation
  Recruiting
• The BRIgHT Program: Building Resilience in HIV Together

  NCT03673098

  Condition:   Resilience, Psychological
  Intervention:   Behavioral: Adapted 3RP
  Sponsors:   Massachusetts General Hospital;   National Center for Complementary and Integrative Health (NCCIH)
  Recruiting
• Paresthesia Free Spinal Cord Stimulation (PF-SCS)

  NCT03670147

  Conditions:   SCS;   Chronic Pain
  Intervention:   Device: PF-SCS programming
  Sponsor:   Massachusetts General Hospital
  Recruiting
• OMega-3 Fatty Acid for the Immune Modulation of Colon Cancer

  NCT03661047

  Condition:   Colon Cancer
  Intervention:   Drug: AMR101 (VASCEPA, icosapent ethyl)
  Sponsors:   Mingyang Song;   Harvard School of Public Health
  Recruiting
• Development of a Positive Psychology Intervention to Improve Mood and HRQoL in Patients Post-HSCT - Proof of Concept

  NCT03654404

  Conditions:   Hematologic Malignancy;   Hematopoietic/Lymphoid Cancer;   Blood Cancer
  Intervention:   Behavioral: Positive Psychology Intervention
  Sponsors:   Dana-Farber Cancer Institute;   Harvard Medical School
  Recruiting
• Durapore vs. Hy-Tape to Secure The Endotracheal Tube

  NCT03633877

  Condition:   Erythema
  Intervention:   Device: DuraporeTM and Hy-Tape®
  Sponsor:   Tufts Medical Center
  Recruiting
• Pan-genotypic Direct Acting Antiviral Therapy in Donor HCV-positive to Recipient HCV-negative Lung Transplant

  NCT03625687

  Conditions:   Respiratory Failure;   Hepatitis C
  Intervention:   Drug: Clinically prescribed direct acting antiviral (Mavyret or Epclusa) HCV treatment for 12 weeks
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Tai Chi and Wellness Education for Older Veterans

  NCT03624868

  Conditions:   Physical Activity;   PTSD;   Satisfaction
  Interventions:   Behavioral: Tai Chi;   Behavioral: Wellness Education
  Sponsors:   VA Boston Healthcare System;   National Institute on Aging (NIA);   Boston University
  Recruiting
• Virtual Reality in the Operating Room

  NCT03614325

  Conditions:   Anesthesia, Intravenous;   Pain, Postoperative;   Delayed Recovery From Anesthesia;   Satisfaction;   Relaxation Therapy
  Intervention:   Other: Virtual Reality Immersive Relaxation
  Sponsors:   Beth Israel Deaconess Medical Center;   VRHealth Group Ltd
  Recruiting
• Venetoclax Added to Fludarabine + Busulfan Prior to Transplant for AML, MDS, and MDS/MPN

  NCT03613532

  Conditions:   Acute Myeloid Leukemia (AML);   Myelodysplastic Syndrome (MDS);   Chronic Myelomonocytic Leukemia (CMML);   MDS/Myeloproliferative Neoplasm-unclassifiable (MDS/MPN-unclassifiable);   Hematopoietic Stem Cell Transplant
  Interventions:   Drug: Venetoclax;   Drug: Fludarabine;   Drug: Busulfan
  Sponsor:   Jacqueline Garcia, MD
  Recruiting
• Inpatient ICOUGH RECOVERY App Version 2.0

  NCT03599037

  Conditions:   Post Operative Complications;   Pneumonia
  Intervention:   Other: ICOUGH Recovery App v2.0
  Sponsor:   Boston Medical Center
  Recruiting
• Topical Calcipotriene Treatment for Breast Cancer Immunoprevention

  NCT03596073

  Condition:   Breast Cancer
  Interventions:   Drug: Topical Calcipotriene Ointment;   Other: Topical Vaseline
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Shingrix Vaccine in Patients With Moderate to Severe Ulcerative Colitis on Tofacitinib

  NCT03591770

  Condition:   Inflammatory Bowel Diseases
  Intervention:   Biological: SHINGRIX
  Sponsor:   Boston Medical Center
  Recruiting
• Osimertinib In EGFR Mutant Lung Cancer

  NCT03586453

  Condition:   Carcinoma, Non-Small-Cell Lung
  Intervention:   Drug: Osimertinib
  Sponsors:   Dana-Farber Cancer Institute;   AstraZeneca
  Recruiting
• OKS for Gait Instability

  NCT03579186

  Conditions:   Gait, Unsteady;   Vestibular Disorder
  Intervention:   Device: OKS
  Sponsor:   Beth Israel Deaconess Medical Center
  Recruiting
• Engaging Working Memory and Distress Tolerance to Aid Smoking Cessation

  NCT03565497

  Condition:   Smoking Cessation
  Interventions:   Behavioral: Wellness Education Control Condition;   Behavioral: Mindfulness Training;   Behavioral: Mindfulness Training Plus IE
  Sponsor:   Boston University Charles River Campus
  Recruiting
• IDH1 Inhibition Using Ivosidenib as Maintenance Therapy for IDH1-mutant Myeloid Neoplasms Following Allogeneic Stem Cell Transplantation

  NCT03564821

  Condition:   IDH1 Mutation Myeloid Neoplasms
  Intervention:   Drug: Ivosidenib
  Sponsors:   Massachusetts General Hospital;   Agios Pharmaceuticals, Inc.
  Recruiting
• Golf Instruction Versus Tai Chi for People With Parkinson's Disease

  NCT03563807

  Conditions:   Parkinson Disease;   Movement Disorders;   Neuro-Degenerative Disease
  Interventions:   Other: Golf Instruction;   Other: Tai Chi Class
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Mobile-based Social Services Screening and Referral Tool in an Pediatric Emergency Department

  NCT03562910

  Conditions:   Poverty;   Social Determinants of Health;   Mobile Applications;   Pediatric ALL;   Emergencies
  Intervention:   Other: HelpSteps application
  Sponsors:   Boston Children’s Hospital;   Verizon Foundation
  Recruiting
• A Randomized Controlled Trial of an Advanced Care Planning Video Decision Support Tool for Patients With End-Stage Liver Disease

  NCT03557086

  Condition:   End Stage Liver Disease
  Interventions:   Behavioral: Advance Care Planning Video Decision Support Tool;   Other: Verbal Narrative
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Preliminary Evaluation of [68Ga]CBP8 in Healthy Individuals, Lung Cancer, and Idiopathic Pulmonary Fibrosis Patients

  NCT03535545

  Conditions:   Pulmonary Fibrosis;   Lung Cancer
  Interventions:   Drug: [68Ga]CBP8;   Diagnostic Test: PET Imaging
  Sponsors:   Massachusetts General Hospital;   National Heart, Lung, and Blood Institute (NHLBI)
  Recruiting
• Central and Peripheral Effects of Cognitive Behavioral Therapy on Brain-Gut Axis Signaling in Gastroparetic Patients

  NCT03531450

  Condition:   Gastroparesis
  Intervention:   Behavioral: Cognitive Behavioral Therapy
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Application of IV 99mTc-tilmanocept for Imaging of Macrophage-specific Inflammation

  NCT03523130

  Condition:   HIV
  Intervention:   Diagnostic Test: Imaging
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Biktarvy for Non-Occupational Post-Exposure Prophylaxis (nPEP)

  NCT03499483

  Condition:   HIV Prevention
  Intervention:   Drug: bictegravir
  Sponsor:   Fenway Community Health
  Recruiting
• Examining the Association Between Pre-existing Sleep Disturbance and Postoperative Delirium

  NCT03498560

  Condition:   Delirium
  Intervention:   Device: PSG
  Sponsor:   Massachusetts General Hospital
  Recruiting
• A Study of Prexasertib (LY2606368), CHK1 Inhibitor, and LY3300054, PD-L1 Inhibitor, in Patients With Advanced Solid Tumors

  NCT03495323

  Condition:   Cancer
  Interventions:   Drug: LY3300054;   Drug: Prexasertib
  Sponsors:   Dana-Farber Cancer Institute;   Eli Lilly and Company
  Recruiting
• Prospective Phenotyping of Autonomous Aldosterone Secretion

  NCT03484130

  Conditions:   Aldosterone Disorder;   Adrenal Gland Disease;   Blood Pressure
  Interventions:   Dietary Supplement: Sodium loaded diet;   Dietary Supplement: Restricted sodium diet;   Drug: Angiotensin II;   Drug: Para-Aminohippurate
  Sponsors:   Brigham and Women's Hospital;   National Institutes of Health (NIH)
  Recruiting
• Biorepository Studying the Relationship Between Biomarkers and Heart Failure

  NCT03480633

  Conditions:   Heart Failure With Normal Ejection Fraction;   Heart Failure With Reduced Ejection Fraction
  Intervention:  
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Study of Pancreatic Enzyme Replacement on Completion of Adjuvant Chemotherapy for Resected Pancreatic Adenocarcinoma

  NCT03469258

  Condition:   Pancreatic Cancer
  Intervention:   Drug: Pancrelipase
  Sponsors:   Dana-Farber Cancer Institute;   Allergan
  Recruiting
• EEG Changes With Guided Online Meditation

  NCT03459690

  Condition:   Meditation
  Interventions:   Behavioral: Meditation;   Device: Enobio 32- EEG machine
  Sponsor:   Beth Israel Deaconess Medical Center
  Recruiting
• The TCF7L2 Gene: Dietary Prevention of T2DM

  NCT03458494

  Conditions:   Type2 Diabetes;   Glucose, High Blood
  Interventions:   Other: Mediterranean Diet;   Other: Low-fat diet
  Sponsors:   Tufts University;   Allen Foundation Inc.
  Recruiting
• MCS110 With BRAF/MEK Inhibition in Patients With Melanoma

  NCT03455764

  Condition:   Melanoma
  Interventions:   Drug: MCS110;   Drug: Dabrafenib;   Drug: Trametinib
  Sponsors:   Dana-Farber Cancer Institute;   Novartis
  Recruiting
• OKS for the Treatment of Hemispatial Neglect

  NCT03451708

  Conditions:   Neglect, Hemispatial;   Neglect, Sensory;   Neglect, Hemisensory
  Intervention:   Device: OKS
  Sponsors:   Beth Israel Deaconess Medical Center;   Johns Hopkins University
  Recruiting
• Mobile Medical Application for Cost-effective Strabismus Screening

  NCT03450980

  Condition:   Strabismus
  Intervention:   Other: EyeTurn App
  Sponsors:   Massachusetts Eye and Ear Infirmary;   National Eye Institute (NEI)
  Recruiting
• Thiamine as a Metabolic Resuscitator After Cardiac Arrest

  NCT03450707

  Condition:   Cardiac Arrest
  Interventions:   Drug: Thiamine 500 mg IV;   Other: Placebo
  Sponsors:   Michael Donnino;   National Heart, Lung, and Blood Institute (NHLBI)
  Recruiting
• Treadmill Exercise in Metabolic Syndrome

  NCT03435315

  Condition:   Metabolic Syndrome
  Interventions:   Other: Treadmill Exercise- behavioral approach;   Other: Treadmill Exercise- traditional approach
  Sponsor:   Beth Israel Deaconess Medical Center
  Recruiting
• Depression and Body Image Distress Following Mastectomy With Reconstruction

  NCT03428399

  Conditions:   Breast Cancer;   BRCA1 Mutation;   BRCA2 Mutation
  Intervention:   Other: Psychosocial variables
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Decision-making Impairments in OCD: An Integrated Behavioral Economics Model

  NCT03420495

  Condition:   Obsessive-Compulsive Disorder
  Intervention:   Behavioral: Decision-Making Tasks
  Sponsors:   Massachusetts General Hospital;   Obsessive Compulsive Foundation
  Recruiting
• Fecal Microbiota Transplant as Treatment of Hepatic Encephalopathy

  NCT03420482

  Condition:   Hepatic Encephalopathy
  Interventions:   Drug: Fecal Microbiota Transplant (FMT) oral capsules;   Drug: Placebo oral capsule
  Sponsors:   Massachusetts General Hospital;   Center for Microbiome Informatics and Therapeutics
  Recruiting
• Preliminary Study 2 to Test the Effects of Ambulatory Voice Biofeedback

  NCT03416868

  Conditions:   Vocal Fold Nodules;   Muscle Tension Dysphonia
  Intervention:   Behavioral: Ambulatory voice biofeedback
  Sponsors:   Massachusetts General Hospital;   National Institute on Deafness and Other Communication Disorders (NIDCD)
  Recruiting
• Preliminary Study 1 to Test the Effects of Ambulatory Voice Biofeedback

  NCT03416829

  Condition:   Vocal Fold Nodules
  Intervention:   Behavioral: Ambulatory voice biofeedback
  Sponsors:   Massachusetts General Hospital;   National Institute on Deafness and Other Communication Disorders (NIDCD)
  Recruiting
• The Role of Cognitive Control in the Transdiagnostic Conceptualization of "Intrusive Thoughts"

  NCT03414619

  Conditions:   Obsessive-Compulsive Disorder;   Generalized Anxiety Disorder;   Major Depressive Disorder
  Intervention:   Behavioral: Cognitive Control Tasks and Script Driven Imagery
  Sponsors:   Massachusetts General Hospital;   Health Resources in Action, Inc.
  Recruiting
• Integrating Mind-Body Skills With Physical Activity to Improve Physical and Emotional Outcomes in Patients With Chronic Pain

  NCT03412916

  Conditions:   Pain;   Chronic Pain;   Physical Activity
  Interventions:   Behavioral: p3RP;   Behavioral: p3RP-DMD
  Sponsor:   Massachusetts General Hospital
  Recruiting
• 25-Hydroxyvitamin D Pharmacokinetic Study

  NCT03401541

  Conditions:   Vitamin D Deficiency;   Fat Malabsorption
  Interventions:   Drug: Calcifediol;   Drug: Calciferol
  Sponsor:   Boston University
  Recruiting
• Neuroimaging Biomarkers of Prognosis in Motor Functional Neurological Disorders

  NCT03398070

  Condition:   Conversion Disorder
  Intervention:   Other: Standard of Care
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Treatment of Macular Edema After Cataract Surgery With Subconjunctival Aflibercept

  NCT03396861

  Condition:   Irvine-Gass Syndrome
  Intervention:   Drug: Aflibercept
  Sponsors:   Tufts Medical Center;   Regeneron Pharmaceuticals
  Recruiting
• Electronic Symptom Monitoring Intervention for Hospitalized Patients With Cancer

  NCT03396510

  Condition:   Cancer
  Intervention:   Other: IMPROVED intervention
  Sponsors:   Massachusetts General Hospital;   Alliance for Clinical Trials in Oncology Cancer Control Program (CCP)
  Recruiting
• Hypoglycemia and the Gut Microbiome

  NCT03385707

  Condition:   Hypoglycemia
  Intervention:   Device: Dexcom continuous glucose monitor and activity monitor
  Sponsor:   Joslin Diabetes Center
  Recruiting
• (Botox) Mechanisms of Action in Altering the Molecular Environment in Which Pain Fibers Exist

  NCT03381261

  Condition:   Migraine
  Intervention:   Drug: Botulinum toxin type A
  Sponsors:   Massachusetts General Hospital;   Beth Israel Deaconess Medical Center
  Recruiting
• Growth Hormone Releasing Hormone Analog to Improve Nonalcoholic Fatty Liver Disease and Associated Cardiovascular Risk

  NCT03375788

  Conditions:   Non-Alcoholic Fatty Liver Disease;   Obesity;   Obesity, Abdominal;   Liver Fat;   Fatty Liver
  Interventions:   Drug: Tesamorelin;   Drug: Identical Placebo
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Psychological Intervention Mobile App for Patients With AML

  NCT03372291

  Condition:   Acute Myeloid Leukemia
  Interventions:   Other: Usual Care;   Other: Psychological intervention
  Sponsor:   Massachusetts General Hospital
  Recruiting
• BOLSTER: Building Out Lifelines for Safety, Trust, Empowerment and Renewal

  NCT03367247

  Condition:   Ovarian Cancer
  Intervention:   Other: Bolster
  Sponsors:   Dana-Farber Cancer Institute;   National Cancer Institute (NCI)
  Recruiting
• Stepping Into Survivorship: Harnessing Behavioral Economics to Improve Quality of Life in Ovarian Cancer

  NCT03364673

  Condition:   Ovarian Cancer
  Interventions:   Other: Fitness Tracker;   Other: Social Incentive (Way to Health)
  Sponsors:   Dana-Farber Cancer Institute;   National Cancer Institute (NCI)
  Recruiting
• Bridge: Proactive Psychiatry Consultation and Case Management for Patients With Cancer

  NCT03360695

  Conditions:   Cancer;   Severe Major Depression;   Schizophrenia;   Bipolar Disorder;   Lung Cancer;   Breast Cancer;   Head and Neck Cancer;   Gastrointestinal Cancer
  Interventions:   Other: Proactive Psychiatry Consultation (PPC);   Other: Enhanced Usual Care (EUC)
  Sponsors:   Massachusetts General Hospital;   Harvard Risk Management Foundation;   National Cancer Institute (NCI)
  Recruiting
• Continuous Glucose Monitoring to Reduce Hypoglycemia and Improve Safety in Patients With Hypoglycemia After Gastric Surgery

  NCT03353415

  Conditions:   Hypoglycemia, Reactive;   Hypoglycemia
  Intervention:   Device: Dexcom continuous glucose monitor
  Sponsors:   Joslin Diabetes Center;   DexCom, Inc.
  Recruiting
• Physical Activity In Gastrointestinal Cancer

  NCT03331406

  Conditions:   Metastatic Gastrointestinal Cancer;   Physical Activity
  Intervention:   Other: Physical Activity Program
  Sponsor:   Dana-Farber Cancer Institute
  Recruiting
• Psychological Intervention for Caregivers of Patients Undergoing Stem Cell Transplant

  NCT03328663

  Condition:   Cancer
  Interventions:   Other: CARE;   Other: Standard Transplant Care
  Sponsors:   Massachusetts General Hospital;   National Cancer Institute (NCI)
  Recruiting
• APOA2 Gene, Diet, Inflammation and Gut Health

  NCT03322449

  Condition:   Inflammation
  Interventions:   Other: Animal Diet;   Other: Plant Diet
  Sponsor:   Tufts University
  Recruiting
• Kidney Information Network for Disease Research and Education

  NCT03321604

  Conditions:   ESRD;   Fabry Disease;   Rare Diseases;   Kidney Diseases;   End Stage Renal Disease;   Genetic Diseases, X-Linked
  Intervention:  
  Sponsors:   Massachusetts General Hospital;   Genzyme, a Sanofi Company;   Scott and White Hospital & Clinic
  Recruiting
• Measuring Skin Elasticity in Lymphedema Patients

  NCT03313999

  Conditions:   Diagnoses Disease;   Lymphedema
  Intervention:   Device: Lymphedema Indentometer
  Sponsor:   Beth Israel Deaconess Medical Center
  Recruiting
• HCV Post-Exposure Prophylaxis for Health Care Workers

  NCT03313414

  Condition:   Hepatitis C
  Intervention:   Drug: Sofosbuvir/Velpatasvir Treatment for 14 days
  Sponsors:   Massachusetts General Hospital;   Gilead Sciences
  Recruiting
• A Collaborative Palliative and Leukemia Care Model for Patients With AML Receiving Non-Intensive Therapy

  NCT03310918

  Condition:   Acute Myeloid Leukemia
  Interventions:   Other: Palliative Care;   Other: Standard Leukemia care
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Study of the CDK4/6 Inhibitor Abemaciclib in Solid Tumors Harboring Genetic Alterations in Genes Encoding D-type Cyclins or Amplification of CDK4 or CDK6

  NCT03310879

  Condition:   Cancer
  Intervention:   Drug: Abemaciclib
  Sponsors:   Dana-Farber Cancer Institute;   Eli Lilly and Company
  Recruiting
• Adapted Cognitive Behavioral Treatment for Depression in Patients With Moderate to Severe Traumatic Brain Injury

  NCT03307070

  Conditions:   Major Depressive Disorder;   Traumatic Brain Injury
  Interventions:   Behavioral: Cognitive Behavioral Therapy for individuals with TBI;   Other: Waitlist Control
  Sponsors:   Massachusetts General Hospital;   Spaulding Rehabilitation Hospital
  Recruiting
• Acetaminophen Given Per Os and Intravenous in Sinus Surgery

  NCT03295214

  Condition:   Acetaminophen
  Intervention:   Drug: Acetaminophen
  Sponsor:   Massachusetts Eye and Ear Infirmary
  Recruiting
• Study of Core Needle Biopsy and Cryoablation of an Enlarging Tumor in Patients With Metastatic Lung Cancer and Metastatic Melanoma Receiving Post-progression Immune Checkpoint Inhibitor Therapy

  NCT03290677

  Condition:   Lung Cancer
  Interventions:   Procedure: Cryoablation;   Procedure: Biopsy
  Sponsors:   Massachusetts General Hospital;   William M. Wood Foundation
  Recruiting
• Local Control, Quality of Life and Toxicities in Adults With Benign or Indolent Brain Tumors Undergoing Proton Radiation Therapy

  NCT03286335

  Condition:   Brain Tumor
  Intervention:   Radiation: Proton Radiation
  Sponsor:   Massachusetts General Hospital
  Recruiting
• A Pilot Study of FOLFIRINOX in Combination With Neoadjuvant Radiation for Gastric and GE Junction Cancers

  NCT03279237

  Condition:   GastroEsophageal Cancer
  Interventions:   Drug: Irinotecan;   Drug: Oxaliplatin;   Drug: Leucovorin;   Drug: 5-Fluorouracil;   Drug: Paclitaxel;   Radiation: Radiation Therapy;   Drug: Carboplatin
  Sponsors:   Massachusetts General Hospital;   National Cancer Institute (NCI)
  Recruiting
• INCB039110 in Combination With Dabrafenib and Trametinib in Patients With BRAF-mutant Melanoma and Other Solid Tumors.

  NCT03272464

  Condition:   Melanoma
  Interventions:   Drug: Trametinib;   Drug: Dabrafenib;   Drug: INCB039110
  Sponsors:   Massachusetts General Hospital;   Incyte Corporation
  Recruiting
• Effect of a Probiotic Mixture on the Gut Microbiome and Fatigue in Patients With Quiescent Inflammatory Bowel Disease

  NCT03266484

  Conditions:   Inflammatory Bowel Diseases;   Crohn Disease;   Ulcerative Colitis
  Interventions:   Dietary Supplement: Probiotic Mixture;   Dietary Supplement: Placebo
  Sponsors:   Massachusetts General Hospital;   Winclove Bio Industries BV
  Recruiting
• Validation of a Single Rest-Stress Imaging Protocol for Myocardial Perfusion Imaging

  NCT03265535

  Conditions:   Coronary Artery Disease;   Myocardial Ischemia
  Intervention:   Diagnostic Test: Single-Scan Two-Injection Protocol
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Evaluation of PET/MR in Patients Selected for Ablation Therapy

  NCT03265431

  Condition:   Arrhythmias, Cardiac
  Intervention:   Drug: 18F-TPP
  Sponsor:   Massachusetts General Hospital
  Recruiting
• PRECISION Study: Evaluating the Accuracy of the LabPatch Continuous Glucose Monitor

  NCT03262415

  Conditions:   Type1 Diabetes Mellitus;   Type 2 Diabetes Mellitus
  Intervention:   Device: LabPatch Continuous Glucose Monitoring (CGM)
  Sponsors:   Joslin Diabetes Center;   Cambridge Medical Technologies, LLC
  Recruiting
• Esophageal Deviation in Atrial Fibrillation Ablation

  NCT03261973

  Condition:   Atrial Fibrillation
  Intervention:   Device: DV8
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Recovering From Intimate Partner Violence Through Strengths and Empowerment (RISE)

  NCT03261700

  Conditions:   Intimate Partner Violence;   Empowerment
  Interventions:   Behavioral: RISE;   Other: Information and referral condition
  Sponsors:   VA Office of Research and Development;   VA Boston Healthcare System;   VA Connecticut Healthcare System
  Recruiting
• Feasibility of Outpatient Closed Loop Control With the Bionic Pancreas in Cystic Fibrosis Related Diabetes

  NCT03258853

  Condition:   Cystic Fibrosis-related Diabetes
  Interventions:   Device: Bionic Pancreas;   Other: Usual Care
  Sponsors:   Massachusetts General Hospital;   Boston University
  Recruiting
• Nivolumab Plus Ipilimumab in Thyroid Cancer

  NCT03246958

  Condition:   Thyroid Cancer
  Interventions:   Drug: Nivolumab;   Drug: Ipilimumab
  Sponsors:   Dana-Farber Cancer Institute;   Bristol-Myers Squibb
  Recruiting
• Oral Versus Intravenous Sedation for Ocular Procedures

  NCT03246724

  Conditions:   Surgery;   Sedation
  Interventions:   Drug: Triazolam;   Drug: Midazolam;   Drug: Microcrystalline Cellulose;   Drug: Sodium chloride 0.9%
  Sponsor:   Boston Medical Center
  Recruiting
• Trial to Reduce Antimicrobial Use In Nursing Home Residents With Alzheimer's Disease and Other Dementias

  NCT03244917

  Conditions:   Dementia;   Infection, Bacterial
  Intervention:   Behavioral: TRAIN-AD
  Sponsor:   Hebrew Rehabilitation Center, Boston
  Recruiting
• Post-Operative Ambulatory Challenge and Exercise (PACE) Trial

  NCT03234933

  Condition:   Cancer
  Intervention:   Device: Mobility Tracker
  Sponsor:   Dana-Farber Cancer Institute
  Recruiting
• Patient Navigation to Improve Patient-Centered Cancer Care

  NCT03226405

  Condition:   Cancer
  Interventions:   Other: Patient Navigation Program;   Other: Usual Care
  Sponsor:   Massachusetts General Hospital
  Recruiting
• A Study of Ulocuplumab And Ibrutinib in Symptomatic Patients With Mutated CXCR4 Waldenstrom's Macroglobulinemia

  NCT03225716

  Condition:   Waldenstrom's Macroglobulinemia
  Interventions:   Drug: Ulocuplumab;   Drug: Ibrutinib
  Sponsors:   Dana-Farber Cancer Institute;   Bristol-Myers Squibb
  Recruiting
• Validation of Novel Predictive Score for Patients With Spinal Metastases

  NCT03224650

  Condition:   Spinal Metastases
  Intervention:  
  Sponsor:   Brigham and Women's Hospital
  Recruiting
• Effect of Medical Marijuana on Neurocognition and Escalation of Use

  NCT03224468

  Conditions:   Pain;   Insomnia;   Depression;   Anxiety
  Intervention:   Drug: Medical Marijuana
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Researching Emotions And Cardiac Health: Phase III

  NCT03220204

  Conditions:   Congestive Heart Failure;   Emotions;   Patient Compliance
  Interventions:   Behavioral: PP-based health behavior intervention;   Behavioral: MI-based educational control condition
  Sponsors:   Massachusetts General Hospital;   National Institutes of Health (NIH);   National Heart, Lung, and Blood Institute (NHLBI)
  Recruiting
• Initiating Substance Use Disorder Treatment for Hospitalized Opioid Use Disorder Patients.

  NCT03212794

  Condition:   Opioid-use Disorder
  Intervention:   Behavioral: Recovery coach
  Sponsors:   Brigham and Women's Hospital;   National Institute on Drug Abuse (NIDA)
  Recruiting
• DAA Treatment in Donor HCV-positive to Recipient HCV-negative Heart Transplant

  NCT03208244

  Conditions:   End Stage Heart Disease;   Hepatitis C
  Intervention:   Drug: Clinically prescribed direct acting antiviral
  Sponsor:   Massachusetts General Hospital
  Recruiting
• DAA Treatment in Donor HCV-positive to Recipient HCV-negative Liver Transplant

  NCT03208127

  Conditions:   End Stage Liver Disease;   Hepatitis C
  Intervention:   Drug: Treatment with Direct Acting Antiviral tablet
  Sponsor:   Massachusetts General Hospital
  Recruiting
• A Phase IB/II Study of Alectinib Combined With Cobimetinib in Advanced ALK-Rearranged (ALK+) NSCLC

  NCT03202940

  Condition:   Non-small Cell Lung Cancer
  Interventions:   Drug: Alectinib;   Drug: Cobimetinib
  Sponsors:   Massachusetts General Hospital;   Genentech, Inc.
  Recruiting
• Open Lung Strategy, Gas Distribution and Right Heart Function in ARDS Patients

  NCT03202641

  Conditions:   ARDS, Human;   Lung Injury, Acute;   Respiratory Distress Syndrome;   Mechanical Ventilation Complication;   Alveolar Edema;   Right Heart Failure;   Right Ventricular Dysfunction
  Interventions:   Procedure: PEEP ARDSnet;   Procedure: PEEP LRM
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Measurement of Renal Functional Reserve

  NCT03190070

  Condition:   Kidney Diseases
  Intervention:   Dietary Supplement: Ingestion of protein
  Sponsor:   Brigham and Women's Hospital
  Recruiting
• A Psychological-behavioral Intervention to Increase Activity in Type 2 Diabetes

  NCT03164538

  Condition:   Type 2 Diabetes Mellitus
  Interventions:   Behavioral: Positive Psychology + Motivational Interviewing;   Behavioral: Diabetes Education
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Oral Tofacitinib in Adult Subjects With Discoid Lupus Erythematosus (DLE) and Systemic Lupus Erythematosus (SLE)

  NCT03159936

  Conditions:   Discoid Lupus Erythematosus;   Systemic Lupus Erythematosus
  Intervention:   Biological: Tofacitinib citrate
  Sponsors:   Tufts Medical Center;   Pfizer
  Recruiting
• A Psychological-behavioral Intervention for Physical Activity in Type 2 Diabetes

  NCT03150199

  Condition:   Type2 Diabetes
  Interventions:   Behavioral: Positive Psychology + Motivational Interviewing;   Behavioral: MI-based Health Education Intervention
  Sponsor:   Massachusetts General Hospital
  Recruiting
• A Phase 2 Study of Lamivudine in Patients With p53 Mutant Metastatic Colorectal Cancer

  NCT03144804

  Condition:   Colorectal Cancer Metastatic
  Intervention:   Drug: Lamivudine
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Abemaciclib for Patients With Retinoblastoma-Positive, Triple Negative Metastatic Breast Cancer

  NCT03130439

  Condition:   Breast Cancer
  Intervention:   Drug: Abemaciclib
  Sponsors:   Dana-Farber Cancer Institute;   Eli Lilly and Company
  Recruiting
• Feasibility Assessment of the Blood Pressure Imager, a Continuous Blood Pressure Monitor

  NCT03128944

  Conditions:   Blood Pressure;   Hypertension
  Intervention:  
  Sponsor:   Tufts University
  Recruiting
• Nivolumab and Ipilimumab and Radiation Therapy in MSS and MSI High Colorectal and Pancreatic Cancer

  NCT03104439

  Conditions:   Microsatellite Stable Colorectal Cancer;   Pancreatic Cancer;   MSI High Colorectal Cancer
  Interventions:   Drug: Nivolumab;   Drug: Ipilimumab;   Radiation: Radiation Therapy
  Sponsors:   Massachusetts General Hospital;   Bristol-Myers Squibb
  Recruiting
• Migraine and Homeostasis:What Can we Learn From Glucose

  NCT03097536

  Condition:   Migraine Headache
  Intervention:   Other: Luna Bar
  Sponsor:   Beth Israel Deaconess Medical Center
  Recruiting
• Group Therapy for Depressed Dementia Caregivers

  NCT03092050

  Condition:   Depression
  Interventions:   Behavioral: Guided Imagery and Mindfulness;   Behavioral: Facilitated Discussion
  Sponsors:   Massachusetts General Hospital;   National Institute on Aging (NIA)
  Recruiting
• Prevention of Post Mastectomy With Intraoperative Ketamine

  NCT03090776

  Conditions:   Pain, Postoperative;   Post-Mastectomy Chronic Pain Syndrome
  Interventions:   Drug: Ketamine;   Other: Placebo saline
  Sponsors:   Brigham and Women's Hospital;   National Institutes of Health (NIH);   National Institute of General Medical Sciences (NIGMS)
  Recruiting
• Utility of Cortical Bone Tissue Properties in the Assessment of Fracture Risk

  NCT03076034

  Conditions:   Distal Radius Fracture;   Osteoporosis;   Hip Fractures
  Intervention:   Device: Reference Point Indentation
  Sponsors:   Beth Israel Deaconess Medical Center;   Brigham and Women's Hospital
  Recruiting
• Improving Walking Quality and Quantity in Osteoarthritis (IWALQQ-OA)

  NCT03064139

  Condition:   Knee Osteoarthritis
  Interventions:   Behavioral: MCG;   Behavioral: SCG
  Sponsors:   Boston University Charles River Campus;   Boston University;   University of Delaware
  Recruiting
• Laser Enucleation of Prostate (LEP) Versus Transurethral Resection of Prostate (TURP)

  NCT03062111

  Condition:   Benign Prostatic Hyperplasia
  Interventions:   Procedure: ProTouch Laser Enucleation of Prostate (LEP);   Procedure: Transurethral Resection of Prostate (TURP)
  Sponsor:   Boston University
  Recruiting
• A Clinical Trial Testing Root Coverage With Acellular Dermal Matrix in Thin and Thick Gingival Biotypes

  NCT03057730

  Condition:   Gingival Recession
  Intervention:   Biological: Acellular Dermal Matrix
  Sponsor:   Tufts University
  Recruiting
• Combination Study of Prexasertib and Olaparib in Patients With Advanced Solid Tumors

  NCT03057145

  Condition:   Solid Tumor
  Interventions:   Drug: Prexasertib;   Drug: Olaparib
  Sponsors:   Khanh Do;   Eli Lilly and Company;   AstraZeneca
  Recruiting
• Study of Regorafenib in Patients With Advanced Myeloid Malignancies

  NCT03042689

  Condition:   Acute Myeloid Leukemia
  Intervention:   Drug: Regorafenib
  Sponsors:   Massachusetts General Hospital;   Bayer
  Recruiting
• The HOPE Trial:Helping Our Patients Excel

  NCT03022032

  Condition:   Gynecologic Cancer
  Interventions:   Device: Fitbit Zip;   Other: HOPE App;   Other: Standard of Care;   Device: Fitbit Charge 2
  Sponsor:   Dana-Farber Cancer Institute
  Recruiting
• Azacitidine, Durvalumab, and Tremelimumab in Recurrent and/or Metastatic Head and Neck Cancer Patients

  NCT03019003

  Condition:   Head and Neck Cancer
  Interventions:   Drug: Azacitidine;   Drug: Durvalumab;   Drug: Tremelimumab
  Sponsors:   Massachusetts General Hospital;   AstraZeneca
  Recruiting
• Mindful Steps: Promoting Physical Activity

  NCT03003780

  Conditions:   Copd;   Heart Failure
  Intervention:   Behavioral: Mindful Steps
  Sponsor:   Beth Israel Deaconess Medical Center
  Recruiting
• A Study Of Changes In PD-L1 Expression During Preoperative Treatment With Nab-Paclitaxel And Pembrolizumab In Hormone Receptor-Positive Breast Cancer

  NCT02999477

  Condition:   Breast Cancer
  Interventions:   Drug: Pembrolizumab;   Drug: Nab-Paclitaxel;   Procedure: Biopsy
  Sponsors:   Dana-Farber Cancer Institute;   Merck Sharp & Dohme Corp.
  Recruiting
• Activated Vitamin D for the Prevention and Treatment of Acute Kidney Injury

  NCT02962102

  Conditions:   Critically Ill;   Acute Kidney Injury
  Interventions:   Drug: Calcifediol;   Drug: Calcitriol;   Drug: Placebos
  Sponsors:   David Leaf;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
  Recruiting
• An Adjunctive Family Intervention for Individual Posttraumatic Stress Disorder Treatment

  NCT02956434

  Condition:   Posttraumatic Neuroses
  Intervention:   Behavioral: Brief Family Intervention
  Sponsor:   VA Office of Research and Development
  Recruiting
• A Study Combining NeoVax, a Personalized NeoAntigen Cancer Vaccine, With Ipilimumab to Treat High-risk Renal Cell Carcinoma

  NCT02950766

  Condition:   Kidney Cancer
  Interventions:   Drug: NeoVax;   Drug: Ipilimumab
  Sponsors:   Patrick Ott, MD;   Bristol-Myers Squibb;   Oncovir, Inc.
  Recruiting