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• The Brain Stimulation and Physical Therapy Study

  NCT04181658

  Conditions:   Fall;   Gait, Unsteady;   Aging;   Accidental Fall
  Interventions:   Other: Real tDCS and Physical Therapy;   Other: Sham stimulation and Physical Therapy
  Sponsor:   Hebrew Rehabilitation Center, Boston
  Recruiting
• Impact of Protein and Alkali Supplementation on Skeletal Muscle in Older Adults

  NCT04048616

  Conditions:   Age-Related Sarcopenia;   Muscle Loss
  Interventions:   Dietary Supplement: whey protein isolate;   Dietary Supplement: potassium bicarbonate (KHCO3);   Other: microcrystalline cellulose;   Other: maltodextrin powder
  Sponsors:   Tufts University;   National Institute on Aging (NIA)
  Recruiting
• Predicting SSRI Efficacy in Veterans With PTSD

  NCT04183205

  Condition:   Posttraumatic Stress Disorder
  Interventions:   Diagnostic Test: LDAEP;   Drug: Placebo;   Drug: sertraline
  Sponsors:   VA Office of Research and Development;   Middlebury College;   Suffolk University;   Massachusetts General Hospital
  Recruiting
• Image Guided Targeted Photoablation for the Treatment of Localized Hyperhidrosis

  NCT04178161

  Condition:   Hyperhidrosis
  Intervention:   Device: Laser treatment
  Sponsors:   Massachusetts General Hospital;   Sciton
  Recruiting
• Neuromodulation of Executive Function in the ADHD Brain

  NCT04175028

  Condition:   Attention Deficit Hyperactivity Disorder
  Intervention:   Device: Transcranial Direct Current Stimulation
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Even-Up For Ankle Fracture

  NCT04164563

  Conditions:   Arthralgia;   Trouble Balancing
  Intervention:   Device: Even-Up
  Sponsor:   Brigham and Women's Hospital
  Recruiting
• Initiating Early Control of Migraine Pain and Associated Symptoms

  NCT04163185

  Condition:   Migraine
  Interventions:   Drug: AXS-07 (MoSEIC meloxicam and rizatriptan);   Drug: Placebo
  Sponsor:   Axsome Therapeutics, Inc.
  Recruiting
• Control:Diabetes Pilot Study I

  NCT04158921

  Conditions:   Insulin Treated Type 2 Diabetes Mellitus;   Diabetes Mellitus, Type 1
  Intervention:   Other: Control:Diabetes mobile app
  Sponsor:   Brigham and Women's Hospital
  Recruiting
• Virtual Reality for Pain Management in Orthopaedic Patients

  NCT04152447

  Condition:   Pain, Musculoskeletal
  Intervention:   Device: VR device
  Sponsors:   Massachusetts General Hospital;   Orthopaedic Trauma Association
  Recruiting
• Identification of Genetic Causes of Calcific Aortic Valve Disease

  NCT04149600

  Conditions:   Calcific Aortic Stenosis;   Calcific Aortic Stenosis - Bicuspid Valve;   Aortic Valve Disease;   Aortic Valve Calcification;   Aortic Diseases;   Aortic Aneurysm;   Aortic Valve Cusp Abnormality;   Aortic Valve Disease Mixed;   Aortic Valve Insufficiency
  Intervention:   Procedure: Patients scheduled to undergo aortic valve replacement or aortic surgery at BIDMC will be approached for participation in this study.
  Sponsors:   Beth Israel Deaconess Medical Center;   Brigham and Women's Hospital
  Recruiting
• Effectiveness of a Walking Intervention on Impact Loading and Pain

  NCT04148807

  Conditions:   Osteoarthritis, Knee;   Knee Pain Chronic
  Interventions:   Behavioral: Gait Retraining;   Behavioral: Control
  Sponsor:   Northeastern University
  Recruiting
• NEURO-TTRansform: A Study to Evaluate the Efficacy and Safety of AKCEA-TTR-LRx in Participants With Hereditary Transthyretin-Mediated Amyloid Polyneuropathy

  NCT04136184

  Condition:   Hereditary Transthyretin-Mediated Amyloid Polyneuropathy
  Interventions:   Drug: AKCEA-TTR-LRx;   Drug: Inotersen
  Sponsors:   Ionis Pharmaceuticals, Inc.;   Akcea Therapeutics
  Recruiting
• A Phase 2 Study to Evaluate the Safety, Tolerability, PK and PD of ELX-02 in Cystic Fibrosis Patients With G542X Allele

  NCT04135495

  Condition:   Cystic Fibrosis
  Intervention:   Drug: ELX-02
  Sponsor:   Eloxx Pharmaceuticals, Inc.
  Recruiting
• HIV Exposure In Utero and Metabolic Disease Risk in HIV-Negative Young Adults

  NCT04132830

  Condition:   HIV-exposed Uninfected
  Intervention:  
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Effect of Tai Chi as Treatment for IBS-C

  NCT04132804

  Condition:   Irritable Bowel Syndrome With Constipation
  Intervention:   Behavioral: Tai Chi
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Electronic Pill Bottle Monitoring to Promote Medication Adherence for People With Multiple Sclerosis

  NCT04130256

  Condition:   Multiple Sclerosis
  Intervention:   Device: Electronic Pill Bottle
  Sponsors:   Massachusetts General Hospital;   National Multiple Sclerosis Society;   Pillsy, Inc.
  Recruiting
• Effects of Gender-Affirming Hormone Therapy Among Transgender Women

  NCT04128488

  Conditions:   Transgender Women;   HIV/AIDS;   Cardiovascular Diseases;   Metabolic Disease;   Coagulopathy
  Interventions:   Other: Abdominal MR Imaging;   Other: Cardiac MRI/MRS;   Other: Oral Glucose Tolerance Testing;   Other: Whole Body, Lumbar Spine, and Hip DEXA Imaging
  Sponsors:   Massachusetts General Hospital;   National Heart, Lung, and Blood Institute (NHLBI);   National Institutes of Health (NIH)
  Recruiting
• Predicting the Success of Dry Eye Disease Interventions Using Clinical Tests

  NCT04125134

  Condition:   Dry Eye
  Intervention:   Drug: Preservative-free Refresh Optive Advanced Lubricant Eye Drops
  Sponsor:   Tufts Medical Center
  Recruiting
• A Pilot Study of BXCL701 in Patients With Pancreatic Cancer

  NCT04123574

  Conditions:   Cancer of Pancreas;   Cancer of the Pancreas;   Neoplasms, Pancreatic;   Pancreas Cancer;   Pancreatic Cancer
  Intervention:   Drug: Talabostat Mesylate
  Sponsors:   BioXcel Therapeutics Inc;   IQVIA Biotech
  Recruiting
• The Impact of Music on Nociceptive Processing

  NCT04087564

  Conditions:   Pain, Acute;   Pain, Chronic;   Anxiety;   Anxiety Disorders;   Catastrophization;   Healthy
  Intervention:   Other: music intervention
  Sponsor:   Brigham and Women's Hospital
  Recruiting
• Dexamethasone Implant for Retinal Detachment in Uveal Melanoma

  NCT04082962

  Condition:   Exudative Retinal Detachment and Uveal Melanoma
  Intervention:   Drug: Dexamethasone intravitreal implant
  Sponsor:   Ivana K. Kim
  Recruiting
• Trans-abdominal Fetal Pulse Oximetry: Signal Integrity

  NCT04081623

  Condition:   Fetal Distress
  Intervention:   Device: Raydiant Oximetry Sensing System
  Sponsor:   Raydiant Oximetry, Inc.
  Recruiting
• Trans-abdominal Fetal Pulse Oximetry: Tissue Light Scattering

  NCT04081584

  Condition:   Fetal Distress
  Intervention:   Device: ISS Device
  Sponsor:   Raydiant Oximetry, Inc.
  Recruiting
• EEG Monitoring in the Emergency Department

  NCT04070521

  Conditions:   Drug Overdose;   Substance Abuse;   Alcohol Abuse
  Intervention:   Other: Observational EEG Monitoring
  Sponsors:   Massachusetts General Hospital;   Brigham and Women's Hospital
  Recruiting
• Treating Depression in Patients With De Quervain's Tenosynovitis; An Integrated Web Based Skills Intervention

  NCT04069741

  Condition:   De Quervain Disease
  Interventions:   Other: Decision Aid;   Behavioral: Toolkit for de Quervain's
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Is There an Alternative to Immediate Home Physical Therapy Following Total Knee Arthroplasty

  NCT04060251

  Condition:   Total Knee Arthroplasty
  Interventions:   Device: CyMedica e-vive™ System; CY-1000;   Other: iGetBetter telemedicine physical therapy
  Sponsors:   Wolfgang Fitz, M.D.;   CyMedica Orthopedics, Inc
  Recruiting
• Mechanism of Action of Electroconvulsive Therapy

  NCT04059952

  Conditions:   Unipolar Depression;   Bipolar Depression
  Intervention:   Procedure: Electroconvulsive Therapy
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Netarsudil Use After Descemetorhexis Without Endothelial Keratoplasty

  NCT04057053

  Conditions:   Fuchs' Endothelial Dystrophy;   Cataract
  Intervention:   Drug: Netarsudil 0.02% Ophthalmic Solution
  Sponsor:   Massachusetts Eye and Ear Infirmary
  Recruiting
• Integrating Mind Body Skills and Physical Activity in Older Adults With Mild Cognitive Impairment (MCI) and Chronic Pain

  NCT04044183

  Conditions:   Chronic Pain;   Mild Cognitive Impairment;   Older Adults;   Physical Activity
  Interventions:   Behavioral: Active Brains;   Behavioral: Active Brains with Fitbit
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Study to Evaluate Sacituzumab Govitecan in Combination With Talazoparib in Patients With Metastatic Breast Cancer.

  NCT04039230

  Condition:   Breast Cancer
  Interventions:   Drug: Talazoparib;   Drug: Sacituzumab Govitecan
  Sponsors:   Massachusetts General Hospital;   Pfizer
  Recruiting
• Mind Body Therapy for the Treatment of Chronic Pain

  NCT04039139

  Conditions:   Chronic Pain;   Chronic Pain Syndrome
  Interventions:   Behavioral: Mind Body Intervention 1;   Behavioral: Mind Body Intervention 2
  Sponsor:   Beth Israel Deaconess Medical Center
  Recruiting
• Waitlist-Control Trial of Smartphone CBT for Body Dysmorphic Disorder (BDD)

  NCT04034693

  Condition:   Body Dysmorphic Disorders
  Intervention:   Device: Smartphone-delivered CBT for BDD
  Sponsors:   Telefónica Innovación Alpha, S.L;   Massachusetts General Hospital
  Recruiting
• Aspirin for the Treatment of Nonalcoholic Fatty Liver Disease

  NCT04031729

  Conditions:   Nonalcoholic Fatty Liver;   Nonalcoholic Steatohepatitis
  Interventions:   Drug: Aspirin 81 mg;   Drug: Placebo oral tablet
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Screening Magnetic Resonance Imaging of the Brain in Patients With Breast Cancer

  NCT04030507

  Conditions:   Breast Cancer;   HER2-positive Breast Cancer;   Triple Negative Breast Cancer;   Hormone Receptor Positive Malignant Neoplasm of Breast;   Inflammatory Breast Cancer;   Metastatic Breast Cancer
  Intervention:   Device: MRI
  Sponsors:   Dana-Farber Cancer Institute;   Conquer Cancer Foundation
  Recruiting
• Effect of Dried Fruit Intake on Acid-base Balance

  NCT04030351

  Condition:   Acid-Base Balance Disorder
  Intervention:   Other: food - dried fruit
  Sponsors:   Tufts University;   Tufts Medical Center
  Recruiting
• Understanding Chronic Lymphocytic Leukemia

  NCT04028531

  Condition:   Chronic Lymphocytic Leukemia
  Intervention:  
  Sponsors:   Dana-Farber Cancer Institute;   National Cancer Institute (NCI)
  Recruiting
• Medication Abortion for Pregnancy of Unknown Location

  NCT04026789

  Condition:   Pregnancy Related
  Interventions:   Other: Same-day-start;   Other: Delay-for-diagnosis
  Sponsor:   Planned Parenthood League of Massachusetts
  Recruiting
• Bone Modeling Effects of Combined Anabolic/Antiresorptive Administration

  NCT04026256

  Condition:   Postmenopausal Osteoporosis
  Interventions:   Drug: Teriparatide;   Drug: Denosumab
  Sponsor:   Massachusetts General Hospital
  Recruiting
• A Phase 1 Trial of CIML NK Cell Infusion for Myeloid Disease Relapse After Haploidentical Hematopoietic Cell Transplantation

  NCT04024761

  Condition:   Leukemia
  Interventions:   Biological: CIML NK;   Drug: Fludarabine;   Drug: Cyclophosphamide
  Sponsors:   Rizwan Romee;   The Leukemia and Lymphoma Society
  Recruiting
• PET Fibrin Imaging of DVT and PE

  NCT04022915

  Conditions:   Pulmonary Embolism;   Deep Vein Thrombosis;   Venous Thromboembolism
  Interventions:   Drug: 64Cu-FBP8;   Diagnostic Test: PET-CT imaging
  Sponsors:   Peter David Caravan;   National Heart, Lung, and Blood Institute (NHLBI)
  Recruiting
• H+ Mobilization With Dialysate Bicarbonate Variation

  NCT04020757

  Condition:   Chronic Kidney Disease
  Interventions:   Device: variation in dialysis bicarbonate;   Dietary Supplement: Zone Perfect bar
  Sponsors:   Tufts Medical Center;   Dialysis Clinic, Inc.
  Recruiting
• 18Fluorine-Fluciclovine PET/CT for Staging Muscle Invasive Bladder Cancer Preceding Radical Cystectomy

  NCT04018053

  Conditions:   Bladder Cancer;   Urothelial Carcinoma
  Interventions:   Drug: 18F-fluciclovine;   Device: PET/CT
  Sponsors:   Dana-Farber Cancer Institute;   Blue Earth Diagnostics
  Recruiting
• The PATHFINDER Study: A Feasibility Trial

  NCT04016740

  Conditions:   Coronary Artery Disease;   Delirium
  Interventions:   Drug: Ropivacaine;   Drug: Ketamine;   Drug: Remifentanil;   Drug: Dexmedetomidine;   Drug: Rocuronium;   Drug: Propofol;   Drug: Sevoflurane;   Device: EEG monitoring
  Sponsor:   Beth Israel Deaconess Medical Center
  Recruiting
• Dietary Restriction in Vascular Surgery

  NCT04013412

  Conditions:   Vascular Diseases;   Surgery
  Intervention:   Dietary Supplement: Protein-Calorie Restriction
  Sponsor:   Brigham and Women's Hospital
  Recruiting
• Prepared Meals to Prime and Perpetuate Reduced Dietary Sodium Intake in Hemodialysis

  NCT03990311

  Conditions:   Hypertension in Dialysis Patients;   Fluid Overload in Dialysis Patients
  Interventions:   Other: Sodium Restricted Meals;   Other: Control
  Sponsor:   Tufts Medical Center
  Recruiting
• PREDICT 2: Personalized Responses to Dietary Composition Trial 2

  NCT03983733

  Conditions:   Diabetes;   Heart Diseases;   Diet Habit;   Diet Modification;   Microbial Colonization;   Healthy;   Obesity;   Metabolism
  Intervention:   Other: Dietary Intervention
  Sponsors:   Zoe Global Limited;   Massachusetts General Hospital;   Stanford University;   King's College London;   Tufts University
  Recruiting
• Internet-based Videoconferencing to Address Alcohol Use and Pain

  NCT03982433

  Conditions:   Chronic Pain;   Alcohol Use, Unspecified
  Intervention:   Behavioral: Motivation and Cognitive Behavioral Management for Alcohol and Pain
  Sponsors:   Boston University Charles River Campus;   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
  Recruiting
• Development of Novel Behavioral Intervention for Sustainable Weight Loss in Hispanic Adults With Obesity

  NCT03978416

  Condition:   Obesity
  Intervention:   Behavioral: Healthy Weight for Living for Hispanics
  Sponsors:   Tufts University;   Tufts Clinical and Translational Science Institute
  Recruiting
• Highly Challenging Balance Program to Reduce Fall Rate in PD

  NCT03972969

  Condition:   Parkinson's Disease
  Interventions:   Behavioral: Facility-based structured exercise;   Behavioral: Home-based structured exercise;   Behavioral: Health education
  Sponsor:   VA Office of Research and Development
  Recruiting
• Multimodal Mobile Intervention Application (App) to Address Sexual Dysfunction in Hematopoietic Stem Cell Transplant Survivors

  NCT03967379

  Condition:   Other Cancer
  Interventions:   Behavioral: Mobile App + enhanced standard care;   Other: Enhanced Standard Care
  Sponsor:   Massachusetts General Hospital
  Recruiting
• AKT Inhibitor, Ipatasertib, With Endocrine and CDK 4/6 Inhibitor for Patients With Metastatic Breast Cancer (TAKTIC)

  NCT03959891

  Condition:   Breast Cancer
  Interventions:   Drug: Ipatasertib;   Drug: Fulvestrant;   Drug: Aromatase Inhibitor;   Drug: Palbociclib
  Sponsors:   Massachusetts General Hospital;   Genentech, Inc.
  Recruiting
• Version 2 of the Smoking Cessation Smartphone App "Smiling Instead of Smoking" (SiS)

  NCT03951766

  Conditions:   Smoking Cessation;   Smoking, Tobacco
  Intervention:   Behavioral: Smiling Instead of Smoking (SiS) App Version 2
  Sponsors:   Massachusetts General Hospital;   American Cancer Society, Inc.
  Recruiting
• Real-time Intervention for Suicide Risk Reduction

  NCT03950765

  Conditions:   Suicide, Attempted;   Suicide and Self-harm
  Intervention:   Behavioral: Ecological momentary intervention
  Sponsors:   Harvard University;   National Institute of Mental Health (NIMH);   Massachusetts General Hospital
  Recruiting
• Body Composition Ultrasound for Patients With Heart Failure

  NCT03948776

  Condition:   Heart Failure
  Interventions:   Diagnostic Test: BodyMetrix body composition ultrasound;   Diagnostic Test: BodyMetrix body composition ultrasound only
  Sponsor:   Tufts Medical Center
  Recruiting
• Global Atrophie Biomarker Evaluation Study (GABiE)

  NCT03935126

  Condition:   Age-related Macular Degeneration
  Intervention:   Diagnostic Test: Diagnostics
  Sponsor:   Boehringer Ingelheim
  Recruiting
• A Novel Pharmacological Therapy for Obstructive Sleep Apnea

  NCT03919955

  Condition:   Sleep Apnea
  Interventions:   Drug: Atomoxetine;   Drug: Oxybutynin;   Drug: Placebo
  Sponsor:   Brigham and Women's Hospital
  Recruiting
• Comparison of 1550nm Fractional Laser Alone Versus in Combination With Microneedling for the Treatment of Acne Scars

  NCT03901417

  Condition:   Acne Scars
  Interventions:   Device: Fraxel Restore (Non-ablative Fractional Laser);   Device: Fraxel Restore (Non-ablative fractional laser) and SkinPen (Microneedling Device)
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Induction TPN Followed by Nivolumab With Radiation in Locoregionally Advanced Laryngeal and Hypopharyngeal Cancer

  NCT03894891

  Condition:   Head and Neck Cancer
  Interventions:   Drug: Nivolumab;   Drug: Cisplatin;   Drug: Docetaxel;   Radiation: Radioimmunotherapy
  Sponsors:   Dana-Farber Cancer Institute;   Bristol-Myers Squibb
  Recruiting
• Combination Pharmacological Interventions for Multiple Mechanisms of Obstructive Sleep Apnea

  NCT03892772

  Condition:   Sleep Apnea
  Interventions:   Drug: SAS0421a;   Drug: SAS0421b;   Drug: SAS0421c;   Drug: SAS0421d;   Drug: placebo
  Sponsor:   Brigham and Women's Hospital
  Recruiting
• Investigation of Cannabidiol for Reduction of NeuroInflammation in Chronic Back Pain

  NCT03891264

  Condition:   Back Pain, Low
  Intervention:   Drug: Cannabidiol
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Small Moments Big Impact (SMBI)

  NCT03887832

  Condition:   Empathy
  Interventions:   Other: SMBI digital app;   Behavioral: media package;   Other: standard newborn and infant care
  Sponsor:   Boston Medical Center
  Recruiting
• Gamma Induction for Alzheimer's Disease

  NCT03880240

  Conditions:   Alzheimer Disease;   Mild Cognitive Impairment
  Interventions:   Device: Transcranial Alternating Current Stimulation (tACS);   Other: Sham Transcranial Alternating Current Stimulation
  Sponsors:   Beth Israel Deaconess Medical Center;   Massachusetts General Hospital;   National Institutes of Health (NIH);   National Institute on Aging (NIA)
  Recruiting
• MBCT Delivered Via Group Videoconferencing for ACS Patients With Elevated Depression Symptoms

  NCT03878160

  Conditions:   Acute Coronary Syndrome;   Depression;   Myocardial Infarction;   Unstable Angina;   STEMI;   NSTEMI - Non-ST Segment Elevation MI
  Interventions:   Other: Focus Group;   Other: Individual Interview
  Sponsors:   Massachusetts General Hospital;   National Center for Complementary and Integrative Health (NCCIH)
  Recruiting
• Study of Postoperative Radiation Therapy for HPV Associated Oropharyngeal Squamous Cell Carcinoma

  NCT03875716

  Condition:   Head and Neck Cancer
  Intervention:   Radiation: Radiation therapy
  Sponsor:   Dana-Farber Cancer Institute
  Recruiting
• Treating Hyperexcitability in AD With Levetiracetam

  NCT03875638

  Condition:   Alzheimer Disease, Early Onset
  Interventions:   Drug: Levetiracetam;   Drug: Placebo oral capsule
  Sponsor:   Beth Israel Deaconess Medical Center
  Recruiting
• Pharmacological Activation of HMN for OSA Aim 2

  NCT03858751

  Condition:   Obstructive Sleep Apnea
  Interventions:   Drug: Placebo oral capsule;   Drug: LTM1201AZ;   Drug: LTM1201AT;   Drug: LTM1201AG;   Drug: LTM1201AD
  Sponsor:   Brigham and Women's Hospital
  Recruiting
• EHR-embedded OCDT in Breast or GI Cancer

  NCT03858712

  Conditions:   Oral Cancer Directed Therapy;   Breast Cancer;   Gastrointestinal Cancer;   Oral Chemotherapy
  Interventions:   Other: Active Care Team Alert;   Other: Passive Care Team Alert
  Sponsor:   Dana-Farber Cancer Institute
  Recruiting
• Healthy Mind Healthy You: A Study of Mindfulness

  NCT03844321

  Condition:   Stress
  Interventions:   Behavioral: Mindfulness-Based Cognitive Therapy;   Behavioral: Mindfulness Light
  Sponsors:   Massachusetts General Hospital;   University of South Florida;   Global Healthy Living Foundation;   University of North Carolina;   University of California, Los Angeles;   Genetic Alliance;   COPD Foundation;   The Duchenne Registry;   University of California, San Francisco;   Children's Hospital Medical Center, Cincinnati;   Hugo W. Moser Research Institute at Kennedy Krieger, Inc.;   Accelerated Cure Project for Multiple Sclerosis;   Mayo Clinic;   Phelan-McDermid Syndrome Foundation;   Immune Deficiency Foundation;   Brigham and Women's Hospital;   University of Pennsylvania
  Recruiting
• Wellness Tool in Anesthesia Providers

  NCT03844308

  Conditions:   Burnout, Professional;   Occupational Stress;   Affective Symptoms
  Intervention:   Behavioral: Isha Kriya Meditation
  Sponsor:   Beth Israel Deaconess Medical Center
  Recruiting
• Growth Hormone Dynamics and Cardiac Steatosis in HIV

  NCT03826160

  Conditions:   Human Immunodeficiency Virus;   Lipodystrophy;   Cardiac Disease
  Intervention:  
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Yoga for Painful Chemotherapy-Induced Peripheral Neuropathy: A Pilot, Randomized-Controlled Study

  NCT03824860

  Conditions:   Chemotherapy-induced Peripheral Neuropathy;   Yoga;   Chronic Pain;   Neuropathic Pain
  Intervention:   Behavioral: Yoga
  Sponsors:   Dana-Farber Cancer Institute;   Oncology Nursing Foundation
  Recruiting
• Exercise Training to Improve Cognitive Function

  NCT03824639

  Condition:   Mild Cognitive Impairment
  Interventions:   Behavioral: Structured exercise;   Behavioral: Health Education
  Sponsor:   VA Office of Research and Development
  Recruiting
• A Pilot Study of Tomographic Optical Breast Imaging (DBT-TOBI) to Monitor Response to Neoadjuvant Therapy

  NCT03822312

  Condition:   Breast Cancer
  Interventions:   Device: DBT-TOBI;   Device: MRI-TOBI
  Sponsors:   Massachusetts General Hospital;   National Cancer Institute (NCI)
  Recruiting
• Suvorexant on Sleep Disturbance in Patients With Chronic Insomnia and Suboptimally Controlled Type 2 Diabetes

  NCT03818581

  Conditions:   Type 2 Diabetes Mellitus;   Insomnia;   Sleep Disorder;   Inflammation
  Interventions:   Drug: Suvorexant;   Other: Placebo
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Sleep and Circadian Treatments for Shift Workers

  NCT03813654

  Conditions:   Shift-Work Sleep Disorder;   Shift-Work Related Sleep Disturbance
  Interventions:   Behavioral: 8-h Afternoon-Evening Sleep;   Behavioral: 8-h Free Sleep
  Sponsor:   Brigham and Women's Hospital
  Recruiting
• COPD Access to Pulmonary Rehabilitation Intervention

  NCT03794921

  Condition:   COPD
  Intervention:   Other: Every Step Counts
  Sponsor:   VA Office of Research and Development
  Recruiting
• Nutrition Status of Adults Treated With Pegvaliase

  NCT03792451

  Condition:   Phenylketonurias
  Intervention:   Drug: Pegvaliase
  Sponsors:   Boston Children’s Hospital;   BioMarin Pharmaceutical
  Recruiting
• The Use of Dantrolene to Improve Analgesia in Posterior Lumbar Surgery

  NCT03762109

  Condition:   Lumbar Spine Injury
  Interventions:   Drug: Dantrolene;   Drug: Placebo Oral Tablet
  Sponsor:   Beth Israel Deaconess Medical Center
  Recruiting
• A Study of Technology to Improve Glucose Control in Participants With Type 1 Diabetes

  NCT03758430

  Condition:   Diabetes Mellitus, Type 1
  Interventions:   Other: Meal-Tagging App;   Device: Fitness Tracker
  Sponsors:   Eli Lilly and Company;   Joslin Diabetes Center
  Recruiting
• The Effect of SLC19A3 Inhibition on the Pharmacokinetics of Thiamine

  NCT03746106

  Conditions:   Vitamin B1 Deficiency;   Thiamine Deficiency
  Interventions:   Drug: Trimethoprim;   Drug: Metformin;   Dietary Supplement: Vitamin B1
  Sponsors:   University of California, San Francisco;   Tufts University;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   University of California, Davis
  Recruiting
• Computerized Decision Support to Increase Detection of Chronic Thromboembolic Pulmonary Hypertension in Patients With Prior Pulmonary Embolism

  NCT03729544

  Condition:   Chronic Thromboembolic Pulmonary Hypertension
  Intervention:   Behavioral: On-screen computerized decision support alert
  Sponsors:   Brigham and Women's Hospital;   Bayer
  Recruiting
• Computerized Decision Support for Prevention of VTE in Hospitalized Medical Patients Across the Continuum of Care (DC-eALERT)

  NCT03728166

  Condition:   Venous Thromboembolism
  Intervention:   Behavioral: Electronic alert
  Sponsors:   Brigham and Women's Hospital;   Portola Pharmaceuticals
  Recruiting
• Ex Vivo TCR αβ T Cell Depletion for Graft-Versus-Host Disease Prophylaxis in Mismatched Donor Peripheral Blood Stem Cell Transplantation for Hematologic Malignancies

  NCT03717480

  Condition:   Hematologic Malignancy
  Intervention:   Device: ClinicMACs
  Sponsor:   Dana-Farber Cancer Institute
  Recruiting
• Adaptive Support Ventilation in Acute Respiratory Distress Syndrome

  NCT03715751

  Condition:   Acute Respiratory Distress Syndrome
  Interventions:   Other: ASV;   Other: Lung Protective Ventilation
  Sponsor:   Beth Israel Deaconess Medical Center
  Recruiting
• 24 Month Open Label Study of the Tolerability and Efficacy of Inotersen in TTR Amyloid Cardiomyopathy Patients

  NCT03702829

  Condition:   Amyloidosis
  Intervention:   Drug: Inotersen
  Sponsor:   Brigham and Women's Hospital
  Recruiting
• Recovering Together: Building Resiliency in Dyads of Patients Admitted to the Neuroscience Intensive Care Unit (NICU) and Their Caregivers

  NCT03694678

  Condition:   Acute Brain Injuries
  Intervention:   Behavioral: Recovering Together
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Safety and Efficacy of Nivolumab in Treating Oral Proliferative Verrucous Leukoplakia

  NCT03692325

  Condition:   Leukoplakia, Oral
  Intervention:   Drug: Nivolumab
  Sponsors:   Dana-Farber Cancer Institute;   Bristol-Myers Squibb
  Recruiting
• Predicting Progression of Developing Myeloma in a High-Risk Screened Population (PROMISE)

  NCT03689595

  Condition:   Multiple Myeloma
  Intervention:   Other: Sample of Blood
  Sponsors:   Dana-Farber Cancer Institute;   Stand Up To Cancer
  Recruiting
• Effect of Dupilumab on Sleep Apnea in Patients With Rhinosinusitis

  NCT03675022

  Conditions:   Sleep Apnea;   Rhinosinusitis Chronic
  Intervention:   Drug: Dupilumab
  Sponsor:   Brigham and Women's Hospital
  Recruiting
• Ruxolitinib for Bronchiolitis Obliterans Syndrome (BOS) After Allogeneic Hematopoietic Cell Transplantation (HCT)

  NCT03674047

  Condition:   Other Cancer
  Intervention:   Drug: ruxolitinib
  Sponsors:   Massachusetts General Hospital;   Incyte Corporation
  Recruiting
• The BRIgHT Program: Building Resilience in HIV Together

  NCT03673098

  Condition:   Resilience, Psychological
  Intervention:   Behavioral: Adapted 3RP
  Sponsors:   Massachusetts General Hospital;   National Center for Complementary and Integrative Health (NCCIH)
  Recruiting
• Paresthesia Free Spinal Cord Stimulation (PF-SCS)

  NCT03670147

  Conditions:   SCS;   Chronic Pain
  Intervention:   Device: PF-SCS programming
  Sponsor:   Massachusetts General Hospital
  Recruiting
• OMega-3 Fatty Acid for the Immune Modulation of Colon Cancer

  NCT03661047

  Condition:   Colon Cancer
  Intervention:   Drug: AMR101 (VASCEPA, icosapent ethyl)
  Sponsors:   Mingyang Song;   Harvard School of Public Health
  Recruiting
• Peri-Transfusion QOL Assessments (PTQA): A New Paradigm of Transfusion Decision Support for Patients With MDS

  NCT03660228

  Condition:   Myelodysplastic Syndromes
  Intervention:   Other: Peri-Transfusion QOL Assessment
  Sponsors:   Dana-Farber Cancer Institute;   Vera and Joseph Dresner Foundation
  Recruiting
• Development of a Positive Psychology Intervention to Improve Mood and HRQoL in Patients Post-HSCT - Proof of Concept

  NCT03654404

  Conditions:   Hematologic Malignancy;   Hematopoietic/Lymphoid Cancer;   Blood Cancer
  Intervention:   Behavioral: Positive Psychology Intervention
  Sponsors:   Dana-Farber Cancer Institute;   Harvard Medical School
  Recruiting
• Durapore vs. Hy-Tape to Secure The Endotracheal Tube

  NCT03633877

  Condition:   Erythema
  Intervention:   Device: DuraporeTM and Hy-Tape®
  Sponsor:   Tufts Medical Center
  Recruiting
• Venetoclax Added to Fludarabine + Busulfan Prior to Transplant for AML, MDS, and MDS/MPN

  NCT03613532

  Conditions:   Acute Myeloid Leukemia (AML);   Myelodysplastic Syndrome (MDS);   Chronic Myelomonocytic Leukemia (CMML);   MDS/Myeloproliferative Neoplasm-unclassifiable (MDS/MPN-unclassifiable);   Hematopoietic Stem Cell Transplant
  Interventions:   Drug: Venetoclax;   Drug: Fludarabine;   Drug: Busulfan
  Sponsor:   Jacqueline Garcia, MD
  Recruiting
• Inpatient ICOUGH RECOVERY App Version 2.0

  NCT03599037

  Conditions:   Post Operative Complications;   Pneumonia
  Intervention:   Other: ICOUGH Recovery App v2.0
  Sponsor:   Boston Medical Center
  Recruiting
• Topical Calcipotriene Treatment for Breast Cancer Immunoprevention

  NCT03596073

  Condition:   Breast Cancer
  Interventions:   Drug: Topical Calcipotriene Ointment;   Other: Topical Vaseline
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Shingrix Vaccine in Patients With Moderate to Severe Ulcerative Colitis on Tofacitinib

  NCT03591770

  Condition:   Inflammatory Bowel Diseases
  Intervention:   Biological: SHINGRIX
  Sponsor:   Boston Medical Center
  Recruiting
• Osimertinib In EGFR Mutant Lung Cancer

  NCT03586453

  Condition:   Carcinoma, Non-Small-Cell Lung
  Intervention:   Drug: Osimertinib
  Sponsors:   Dana-Farber Cancer Institute;   AstraZeneca
  Recruiting
• OKS for Gait Instability

  NCT03579186

  Conditions:   Gait, Unsteady;   Vestibular Disorder
  Intervention:   Device: OKS
  Sponsor:   Beth Israel Deaconess Medical Center
  Recruiting
• Efficacy and Safety of 0.25% Timolol Gel in Enhancing Full Thickness Skin Grafts Healing and Cosmetic Outcomes

  NCT03579160

  Conditions:   Wound of Skin;   Wound Heal;   Surgical Wound;   Full Thickness Skin Graft Healing
  Interventions:   Drug: 0.25% timolol gel with full-thickness skin grafts;   Other: Vaseline dressing
  Sponsor:   Brigham and Women's Hospital
  Recruiting
• Liver Transplantation With Tregs at MGH

  NCT03577431

  Condition:   Liver Transplant
  Interventions:   Biological: arTreg-CSB;   Procedure: leukapheresis;   Drug: cyclophosphamide;   Drug: mesna;   Drug: everolimus
  Sponsors:   National Institute of Allergy and Infectious Diseases (NIAID);   Immune Tolerance Network (ITN)
  Recruiting
• Multimodality Intervention for Function and Metabolism in SCI

  NCT03576001

  Condition:   Spinal Cord Injuries
  Interventions:   Drug: Testosterone Undecanoate;   Behavioral: hybrid exercise
  Sponsors:   Brigham and Women's Hospital;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   Spaulding Rehabilitation Hospital
  Recruiting
• Engaging Working Memory and Distress Tolerance to Aid Smoking Cessation

  NCT03565497

  Condition:   Smoking Cessation
  Interventions:   Behavioral: Wellness Education Control Condition;   Behavioral: Mindfulness Training;   Behavioral: Mindfulness Training Plus IE
  Sponsor:   Boston University Charles River Campus
  Recruiting
• Mobile-based Social Services Screening and Referral Tool in an Pediatric Emergency Department

  NCT03562910

  Conditions:   Poverty;   Social Determinants of Health;   Mobile Applications;   Pediatric ALL;   Emergencies
  Intervention:   Other: HelpSteps application
  Sponsors:   Boston Children’s Hospital;   Verizon Foundation
  Recruiting
• A Randomized Controlled Trial of an Advanced Care Planning Video Decision Support Tool for Patients With End-Stage Liver Disease

  NCT03557086

  Condition:   End Stage Liver Disease
  Interventions:   Behavioral: Advance Care Planning Video Decision Support Tool;   Other: Verbal Narrative
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Efficacy and Safety of a Nanofat-seeded Biological Scaffold in Healing Lower Limb Surgical Defects

  NCT03548610

  Conditions:   Wound of Skin;   Non-melanoma Skin Cancer;   Skin Graft Complications;   Wound of Lower Leg;   Wound of Knee
  Intervention:   Other: Nanofat-seeded biological scaffold on surgical defect
  Sponsor:   Brigham and Women's Hospital
  Recruiting
• Preliminary Evaluation of [68Ga]CBP8 in Healthy Individuals, Lung Cancer, and Idiopathic Pulmonary Fibrosis Patients

  NCT03535545

  Conditions:   Pulmonary Fibrosis;   Lung Cancer
  Interventions:   Drug: [68Ga]CBP8;   Diagnostic Test: PET Imaging
  Sponsors:   Massachusetts General Hospital;   National Heart, Lung, and Blood Institute (NHLBI)
  Recruiting
• Prospective Study of BK Virus Disease After Allogeneic Hematopoietic-cell Transplantation: Defining BK Disease's Natural History, Clinical Spectrum, Immunology, and Outcomes

  NCT03532971

  Condition:   BK Virus Infection
  Interventions:   Other: Symptom index questionnaire;   Diagnostic Test: BK polyomavirus PCR;   Other: quality of life questionnaires
  Sponsor:   Dana-Farber Cancer Institute
  Recruiting
• Central and Peripheral Effects of Cognitive Behavioral Therapy on Brain-Gut Axis Signaling in Gastroparetic Patients

  NCT03531450

  Condition:   Gastroparesis
  Intervention:   Behavioral: Cognitive Behavioral Therapy
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Nutrition in Patient With Critical Limb Ischemia

  NCT03529019

  Conditions:   Critical Limb Ischemia;   Malnutrition;   Nutritional Supplements
  Interventions:   Drug: Ensure Surgery Immunonutrition Shake;   Drug: Ensure Enlive Advanced Nutrition Shake
  Sponsors:   Boston Medical Center;   Vascular & Endovascular Surgery Society;   Abbott
  Recruiting
• Application of IV 99mTc-tilmanocept for Imaging of Macrophage-specific Inflammation

  NCT03523130

  Condition:   HIV
  Intervention:   Diagnostic Test: Imaging
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Paricalcitol Plus Gemcitabine and Nab-paclitaxel in Metastatic Pancreatic Cancer

  NCT03520790

  Condition:   Pancreatic Cancer
  Interventions:   Drug: Gemcitabine;   Drug: Nab-paclitaxel;   Drug: Paricalcitol;   Other: Placebo
  Sponsors:   Dana-Farber Cancer Institute;   Stand Up To Cancer;   Lustgarten Foundation;   American Association for Cancer Research
  Recruiting
• Clinician Decision Support Algorithm for Chemotherapy-Induced Peripheral Neuropathy

  NCT03514680

  Conditions:   Cancer;   Chemotherapy-induced Peripheral Neuropathy
  Intervention:   Behavioral: CIPN Assessment and Management Algorithm
  Sponsor:   Dana-Farber Cancer Institute
  Recruiting
• Examining the Association Between Pre-existing Sleep Disturbance and Postoperative Delirium

  NCT03498560

  Condition:   Delirium
  Intervention:   Device: PSG
  Sponsor:   Massachusetts General Hospital
  Recruiting
• A Study of Prexasertib (LY2606368), CHK1 Inhibitor, and LY3300054, PD-L1 Inhibitor, in Patients With Advanced Solid Tumors

  NCT03495323

  Condition:   Cancer
  Interventions:   Drug: LY3300054;   Drug: Prexasertib
  Sponsors:   Dana-Farber Cancer Institute;   Eli Lilly and Company
  Recruiting
• Prospective Phenotyping of Autonomous Aldosterone Secretion

  NCT03484130

  Conditions:   Aldosterone Disorder;   Adrenal Gland Disease;   Blood Pressure
  Interventions:   Dietary Supplement: Sodium loaded diet;   Dietary Supplement: Restricted sodium diet;   Drug: Angiotensin II;   Drug: Para-Aminohippurate
  Sponsors:   Brigham and Women's Hospital;   National Institutes of Health (NIH)
  Recruiting
• Identification of Predictors for Coronary Plaque Erosion in Patients With Acute Coronary Syndrome

  NCT03479723

  Condition:   Acute Coronary Syndrome
  Intervention:  
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Efficacy and Safety of 0.25% Timolol Gel in Healing Surgical Open Wounds

  NCT03452072

  Conditions:   Wound of Skin;   Wound Heal;   Wound Open;   Surgical Wound
  Interventions:   Drug: 0.25% Timolol gel with paraffin gauze dressings;   Other: Vaseline dressing
  Sponsor:   Brigham and Women's Hospital
  Recruiting
• Mobile Medical Application for Cost-effective Strabismus Screening

  NCT03450980

  Condition:   Strabismus
  Intervention:   Other: EyeTurn App
  Sponsors:   Massachusetts Eye and Ear Infirmary;   National Eye Institute (NEI)
  Recruiting
• Thiamine as a Metabolic Resuscitator After Cardiac Arrest

  NCT03450707

  Condition:   Cardiac Arrest
  Interventions:   Drug: Thiamine 500 mg IV;   Other: Placebo
  Sponsors:   Michael Donnino;   National Heart, Lung, and Blood Institute (NHLBI)
  Recruiting
• Depression and Body Image Distress Following Mastectomy With Reconstruction

  NCT03428399

  Conditions:   Breast Cancer;   BRCA1 Mutation;   BRCA2 Mutation
  Intervention:   Other: Psychosocial variables
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Decision-making Impairments in OCD: An Integrated Behavioral Economics Model

  NCT03420495

  Condition:   Obsessive-Compulsive Disorder
  Intervention:   Behavioral: Decision-Making Tasks
  Sponsors:   Massachusetts General Hospital;   Obsessive Compulsive Foundation
  Recruiting
• Fecal Microbiota Transplant as Treatment of Hepatic Encephalopathy

  NCT03420482

  Condition:   Hepatic Encephalopathy
  Interventions:   Drug: Fecal Microbiota Transplant (FMT) oral capsules;   Drug: Placebo oral capsule
  Sponsors:   Massachusetts General Hospital;   Center for Microbiome Informatics and Therapeutics
  Recruiting
• The Role of Cognitive Control in the Transdiagnostic Conceptualization of "Intrusive Thoughts"

  NCT03414619

  Conditions:   Obsessive-Compulsive Disorder;   Generalized Anxiety Disorder;   Major Depressive Disorder
  Intervention:   Behavioral: Cognitive Control Tasks and Script Driven Imagery
  Sponsors:   Massachusetts General Hospital;   Health Resources in Action, Inc.
  Recruiting
• rTMS as a Treatment for PPA

  NCT03406429

  Conditions:   Logopenic Variant Primary Progressive Aphasia;   Non-Fluent Primary Progressive Aphasia
  Interventions:   Device: Active rTMS;   Device: SHAM rTMS
  Sponsor:   Massachusetts General Hospital
  Recruiting
• 25-Hydroxyvitamin D Pharmacokinetic Study

  NCT03401541

  Conditions:   Vitamin D Deficiency;   Fat Malabsorption
  Interventions:   Drug: Calcifediol;   Drug: Calciferol
  Sponsor:   Boston University
  Recruiting
• Stereotactic Radiation in Patients With Small Cell Lung Cancer and 1-6 Brain Metastases

  NCT03391362

  Conditions:   Brain Metastases;   Small Cell Lung Cancer
  Intervention:   Radiation: Stereotactic Radiation
  Sponsor:   Dana-Farber Cancer Institute
  Recruiting
• Growth Hormone Releasing Hormone Analog to Improve Nonalcoholic Fatty Liver Disease and Associated Cardiovascular Risk

  NCT03375788

  Conditions:   Non-Alcoholic Fatty Liver Disease;   Obesity;   Obesity, Abdominal;   Liver Fat;   Fatty Liver
  Interventions:   Drug: Tesamorelin;   Drug: Identical Placebo
  Sponsor:   Massachusetts General Hospital
  Recruiting
• BOLSTER: Building Out Lifelines for Safety, Trust, Empowerment and Renewal

  NCT03367247

  Condition:   Ovarian Cancer
  Interventions:   Behavioral: BOLSTER;   Other: Enhanced Discharge Planning (EDP)
  Sponsors:   Dana-Farber Cancer Institute;   National Cancer Institute (NCI)
  Recruiting
• Bridge: Proactive Psychiatry Consultation and Case Management for Patients With Cancer

  NCT03360695

  Conditions:   Cancer;   Severe Major Depression;   Schizophrenia;   Bipolar Disorder;   Lung Cancer;   Breast Cancer;   Head and Neck Cancer;   Gastrointestinal Cancer
  Interventions:   Other: Proactive Psychiatry Consultation (PPC);   Other: Enhanced Usual Care (EUC)
  Sponsors:   Massachusetts General Hospital;   Harvard Risk Management Foundation;   National Cancer Institute (NCI)
  Recruiting
• Neodjuvant Nivolumab and Lirilumab, Followed by Surgery, Followed by Adjuvant Nivolumab and Lirilumab, in SCCHN

  NCT03341936

  Condition:   Squamous Cell Carcinoma of the Head and Neck
  Interventions:   Drug: Nivolumab;   Drug: Lirilumab
  Sponsors:   Dana-Farber Cancer Institute;   Bristol-Myers Squibb
  Recruiting
• Physical Activity In Gastrointestinal Cancer

  NCT03331406

  Conditions:   Metastatic Gastrointestinal Cancer;   Physical Activity
  Intervention:   Other: Physical Activity Program
  Sponsor:   Dana-Farber Cancer Institute
  Recruiting
• Psychological Intervention for Caregivers of Patients Undergoing Stem Cell Transplant

  NCT03328663

  Condition:   Cancer
  Interventions:   Other: CARE;   Other: Standard Transplant Care
  Sponsors:   Massachusetts General Hospital;   National Cancer Institute (NCI)
  Recruiting
• Therapeutic Control of Aspirin-Exacerbated Respiratory Disease With Ifetroban

  NCT03326063

  Conditions:   Nasal Polyps;   Asthma, Aspirin-Induced;   Aspirin-exacerbated Respiratory Disease;   Aspirin-Sensitive Asthma With Nasal Polyps
  Interventions:   Drug: Ifetroban;   Drug: Placebo
  Sponsor:   Brigham and Women's Hospital
  Recruiting
• APOA2 Gene, Diet, Inflammation and Gut Health

  NCT03322449

  Condition:   Inflammation
  Interventions:   Other: Animal Diet;   Other: Plant Diet
  Sponsor:   Tufts University
  Recruiting
• Kidney Information Network for Disease Research and Education

  NCT03321604

  Conditions:   ESRD;   Fabry Disease;   Rare Diseases;   Kidney Diseases;   End Stage Renal Disease;   Genetic Diseases, X-Linked
  Intervention:  
  Sponsors:   Massachusetts General Hospital;   Genzyme, a Sanofi Company;   Scott and White Hospital & Clinic
  Recruiting
• HCV Post-Exposure Prophylaxis for Health Care Workers

  NCT03313414

  Condition:   Hepatitis C
  Intervention:   Drug: Sofosbuvir/Velpatasvir Treatment for 14 days
  Sponsors:   Massachusetts General Hospital;   Gilead Sciences
  Recruiting
• Study of the CDK4/6 Inhibitor Abemaciclib in Solid Tumors Harboring Genetic Alterations in Genes Encoding D-type Cyclins or Amplification of CDK4 or CDK6

  NCT03310879

  Condition:   Cancer
  Intervention:   Drug: Abemaciclib
  Sponsors:   Dana-Farber Cancer Institute;   Eli Lilly and Company
  Recruiting
• Study of Core Needle Biopsy and Cryoablation of an Enlarging Tumor in Patients With Metastatic Lung Cancer and Metastatic Melanoma Receiving Post-progression Immune Checkpoint Inhibitor Therapy

  NCT03290677

  Condition:   Lung Cancer
  Interventions:   Procedure: Cryoablation;   Procedure: Biopsy
  Sponsors:   Massachusetts General Hospital;   William M. Wood Foundation
  Recruiting
• Local Control, Quality of Life and Toxicities in Adults With Benign or Indolent Brain Tumors Undergoing Proton Radiation Therapy

  NCT03286335

  Condition:   Brain Tumor
  Intervention:   Radiation: Proton Radiation
  Sponsor:   Massachusetts General Hospital
  Recruiting
• A Pilot Study of FOLFIRINOX in Combination With Neoadjuvant Radiation for Gastric and GE Junction Cancers

  NCT03279237

  Condition:   GastroEsophageal Cancer
  Interventions:   Drug: Irinotecan;   Drug: Oxaliplatin;   Drug: Leucovorin;   Drug: 5-Fluorouracil;   Drug: Paclitaxel;   Radiation: Radiation Therapy;   Drug: Carboplatin
  Sponsors:   Massachusetts General Hospital;   National Cancer Institute (NCI)
  Recruiting
• INCB039110 in Combination With Dabrafenib and Trametinib in Patients With BRAF-mutant Melanoma and Other Solid Tumors.

  NCT03272464

  Condition:   Melanoma
  Interventions:   Drug: Trametinib;   Drug: Dabrafenib;   Drug: INCB039110
  Sponsors:   Massachusetts General Hospital;   Incyte Corporation
  Recruiting
• The Differential Impact of Proton Beam Irradiation Versus Conventional Radiation on Organs-at-risk in Stage II-III Breast Cancer Patients

  NCT03270072

  Conditions:   Breast Cancer Stage II;   Breast Cancer Stage III
  Intervention:  
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Esophageal Deviation in Atrial Fibrillation Ablation

  NCT03261973

  Condition:   Atrial Fibrillation
  Intervention:   Device: DV8
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Recovering From Intimate Partner Violence Through Strengths and Empowerment (RISE)

  NCT03261700

  Conditions:   Intimate Partner Violence;   Empowerment
  Interventions:   Behavioral: RISE;   Other: Information and referral condition
  Sponsors:   VA Office of Research and Development;   VA Boston Healthcare System
  Recruiting
• Feasibility of Outpatient Closed Loop Control With the Bionic Pancreas in Cystic Fibrosis Related Diabetes

  NCT03258853

  Condition:   Cystic Fibrosis-related Diabetes
  Interventions:   Device: Bionic Pancreas;   Other: Usual Care
  Sponsors:   Massachusetts General Hospital;   Boston University
  Recruiting
• Effect of Combined Morphine and Duloxetine on Chronic Pain

  NCT03249558

  Conditions:   Chronic Low Back Pain;   Chronic Neck Pain
  Interventions:   Drug: Morphine;   Drug: Duloxetine;   Drug: Placebo
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Nivolumab Plus Ipilimumab in Thyroid Cancer

  NCT03246958

  Condition:   Thyroid Cancer
  Interventions:   Drug: Nivolumab;   Drug: Ipilimumab
  Sponsors:   Dana-Farber Cancer Institute;   Bristol-Myers Squibb
  Recruiting
• Oral Versus Intravenous Sedation for Ocular Procedures

  NCT03246724

  Conditions:   Surgery;   Sedation
  Interventions:   Drug: Triazolam;   Drug: Midazolam;   Drug: Microcrystalline Cellulose;   Drug: Sodium chloride 0.9%
  Sponsor:   Boston Medical Center
  Recruiting
• Trial to Reduce Antimicrobial Use In Nursing Home Residents With Alzheimer's Disease and Other Dementias

  NCT03244917

  Conditions:   Dementia;   Infection, Bacterial
  Intervention:   Behavioral: TRAIN-AD
  Sponsor:   Hebrew Rehabilitation Center, Boston
  Recruiting
• Novel Strategies to Improve Immunomodulation and Non-invasive Clinical Monitoring in VCA

  NCT03241719

  Conditions:   Amputation, Traumatic;   Amputation;Traumatic;Old;   Face Injury;   Face; Deformity;   Abdominal Wall Defect
  Intervention:   Drug: IL-2
  Sponsor:   Brigham and Women's Hospital
  Recruiting
• Adhering to Dietary Approaches for Personal Taste (ADAPT), Exam 1

  NCT03226938

  Condition:   Dietary Habits
  Intervention:  
  Sponsor:   Tufts University
  Recruiting
• Patient Navigation to Improve Patient-Centered Cancer Care

  NCT03226405

  Condition:   Cancer
  Interventions:   Other: Patient Navigation Program;   Other: Usual Care
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Effect of Medical Marijuana on Neurocognition and Escalation of Use

  NCT03224468

  Conditions:   Pain;   Insomnia;   Depression;   Anxiety
  Intervention:   Drug: Medical Marijuana
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Study of TAS-102 Plus Radiation Therapy for the Treatment of the Liver in Patients With Hepatic Metastases From Colorectal Cancer

  NCT03223779

  Condition:   Colorectal Cancer
  Interventions:   Drug: TAS-102;   Radiation: Photon SBRT
  Sponsors:   Massachusetts General Hospital;   Taiho Oncology, Inc.
  Recruiting
• A Clinical Trial of PGDM1400 and PGT121 and VRC07-523LS Monoclonal Antibodies in HIV-infected and HIV-uninfected Adults

  NCT03205917

  Condition:   HIV Infections
  Interventions:   Biological: PGDM1400/Placebo (3mg/kg IV);   Biological: PGDM1400/Placebo (10mg/kg IV);   Biological: PGDM1400/Placebo (30mg/kg IV);   Biological: PGDM1400 + PGT121/Placebo (3mg/kg + 3mg/kg IV);   Biological: PGDM1400 + PGT121/Placebo (10mg/kg + 10mg/kg IV);   Biological: PGDM1400 + PGT121/Placebo (30mg/kg + 30mg/kg IV);   Biological: PGDM1400 + PGT121 + VRC07-523LS (20mg/kg + 20mg/kg + 20 mg/kg IV);   Biological: PGDM1400 + PGT121 (MTD IV)
  Sponsors:   International AIDS Vaccine Initiative;   Beth Israel Deaconess Medical Center;   Ragon Institute of MGH, MIT and Harvard;   University of Texas Health, Houston AIDS Research Team (HART);   Orlando Immunology Clinic
  Recruiting
• A Phase IB/II Study of Alectinib Combined With Cobimetinib in Advanced ALK-Rearranged (ALK+) NSCLC

  NCT03202940

  Condition:   Non-small Cell Lung Cancer
  Interventions:   Drug: Alectinib;   Drug: Cobimetinib
  Sponsors:   Massachusetts General Hospital;   Genentech, Inc.
  Recruiting
• Open Lung Strategy, Gas Distribution and Right Heart Function in ARDS Patients

  NCT03202641

  Conditions:   ARDS, Human;   Lung Injury, Acute;   Respiratory Distress Syndrome;   Mechanical Ventilation Complication;   Alveolar Edema;   Right Heart Failure;   Right Ventricular Dysfunction
  Interventions:   Procedure: PEEP ARDSnet;   Procedure: PEEP LRM
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Guided Meditation as an Adjunct to Enhance Postoperative Recovery

  NCT03198039

  Condition:   Feasibility of a Meditation Program Perioperatively
  Intervention:   Behavioral: Meditation
  Sponsor:   Beth Israel Deaconess Medical Center
  Recruiting
• Measurement of Renal Functional Reserve

  NCT03190070

  Condition:   Kidney Diseases
  Intervention:   Dietary Supplement: Ingestion of protein
  Sponsor:   Brigham and Women's Hospital
  Recruiting
• A Psychological-behavioral Intervention to Increase Activity in Type 2 Diabetes

  NCT03164538

  Condition:   Type 2 Diabetes Mellitus
  Interventions:   Behavioral: Positive Psychology + Motivational Interviewing;   Behavioral: Diabetes Education
  Sponsor:   Massachusetts General Hospital
  Recruiting
• A Psychological-behavioral Intervention for Physical Activity in Type 2 Diabetes

  NCT03150199

  Condition:   Type2 Diabetes
  Interventions:   Behavioral: Positive Psychology + Motivational Interviewing;   Behavioral: MI-based Health Education Intervention
  Sponsor:   Massachusetts General Hospital
  Recruiting
• A Phase 2 Study of Lamivudine in Patients With p53 Mutant Metastatic Colorectal Cancer

  NCT03144804

  Condition:   Colorectal Cancer Metastatic
  Intervention:   Drug: Lamivudine
  Sponsor:   Massachusetts General Hospital
  Recruiting
• The ICON Study: Outcomes After FMT for Patients With IBD and CDI

  NCT03106844

  Conditions:   Inflammatory Bowel Diseases;   Clostridium Difficile Infection
  Intervention:   Drug: Fecal Microbiota Transplantation
  Sponsors:   Brigham and Women's Hospital;   Indiana University;   Icahn School of Medicine at Mount Sinai;   The Miriam Hospital
  Recruiting
• Nivolumab and Ipilimumab and Radiation Therapy in MSS and MSI High Colorectal and Pancreatic Cancer

  NCT03104439

  Conditions:   Microsatellite Stable Colorectal Cancer;   Pancreatic Cancer;   MSI High Colorectal Cancer
  Interventions:   Drug: Nivolumab;   Drug: Ipilimumab;   Radiation: Radiation Therapy
  Sponsors:   Massachusetts General Hospital;   Bristol-Myers Squibb
  Recruiting
• Bronchial NIR Image-guided Resection

  NCT03097575

  Condition:   Sentinel Lymph Node
  Interventions:   Drug: ICG Intervention;   Device: Near Infrared Imaging
  Sponsors:   Massachusetts General Hospital;   Society of University Surgeons;   Brigham and Women's Hospital
  Recruiting
• Prevention of Post Mastectomy With Intraoperative Ketamine

  NCT03090776

  Conditions:   Pain, Postoperative;   Post-Mastectomy Chronic Pain Syndrome
  Interventions:   Drug: Ketamine;   Other: Placebo saline
  Sponsors:   Brigham and Women's Hospital;   National Institutes of Health (NIH);   National Institute of General Medical Sciences (NIGMS)
  Recruiting
• Targeting PD-1 Therapy Resistance With Focused High or High and Low Dose Radiation in SCCHN

  NCT03085719

  Condition:   Head and Neck Cancer
  Interventions:   Drug: Pembrolizumab;   Radiation: Radiation
  Sponsors:   Dana-Farber Cancer Institute;   Merck Sharp & Dohme Corp.
  Recruiting
• Utility of Cortical Bone Tissue Properties in the Assessment of Fracture Risk

  NCT03076034

  Conditions:   Distal Radius Fracture;   Osteoporosis;   Hip Fractures
  Intervention:   Device: Reference Point Indentation
  Sponsors:   Beth Israel Deaconess Medical Center;   Brigham and Women's Hospital
  Recruiting
• Improving Walking Quality and Quantity in Osteoarthritis (IWALQQ-OA)

  NCT03064139

  Condition:   Knee Osteoarthritis
  Interventions:   Behavioral: MCG;   Behavioral: SCG
  Sponsors:   Boston University Charles River Campus;   Boston University;   University of Delaware
  Recruiting
• Combination Study of Prexasertib and Olaparib in Patients With Advanced Solid Tumors

  NCT03057145

  Condition:   Solid Tumor
  Interventions:   Drug: Prexasertib;   Drug: Olaparib
  Sponsors:   Khanh Do;   Eli Lilly and Company;   AstraZeneca
  Recruiting
• Mechanisms Underlying the Blood Pressure Lowering Effect of Sleep

  NCT03043963

  Condition:   Hypertension
  Interventions:   Behavioral: Sleep Extension;   Behavioral: Sleep Timing
  Sponsor:   Beth Israel Deaconess Medical Center
  Recruiting
• Study of Regorafenib in Patients With Advanced Myeloid Malignancies

  NCT03042689

  Condition:   Acute Myeloid Leukemia
  Intervention:   Drug: Regorafenib
  Sponsors:   Massachusetts General Hospital;   Bayer
  Recruiting
• Partners Calciphylaxis Biobank

  NCT03032835

  Conditions:   Calciphylaxis;   Calcific Uremic Arteriolopathy;   End Stage Renal Disease;   Chronic Kidney Diseases
  Intervention:  
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Molecular and Genetic Analysis of Lung Cancer

  NCT03029325

  Condition:   Lung Cancer
  Intervention:  
  Sponsors:   Massachusetts General Hospital;   National Cancer Institute (NCI)
  Recruiting
• Azacitidine, Durvalumab, and Tremelimumab in Recurrent and/or Metastatic Head and Neck Cancer Patients

  NCT03019003

  Condition:   Head and Neck Cancer
  Interventions:   Drug: Azacitidine;   Drug: Durvalumab;   Drug: Tremelimumab
  Sponsors:   Massachusetts General Hospital;   AstraZeneca
  Recruiting
• Turmeric for Patients With Basal Joint Arthritis

  NCT03017118

  Condition:   Thumb Osteoarthritis
  Interventions:   Dietary Supplement: Turmeric;   Other: Placebo
  Sponsor:   Massachusetts General Hospital
  Recruiting
• A Study Of Changes In PD-L1 Expression During Preoperative Treatment With Nab-Paclitaxel And Pembrolizumab In Hormone Receptor-Positive Breast Cancer

  NCT02999477

  Condition:   Breast Cancer
  Interventions:   Drug: Pembrolizumab;   Drug: Nab-Paclitaxel;   Procedure: Biopsy
  Sponsors:   Dana-Farber Cancer Institute;   Merck Sharp & Dohme Corp.
  Recruiting
• Natural History of Barrett's Esophagus Using Tethered Capsule Endomicroscopy

  NCT02994693

  Conditions:   Barrett Esophagus;   Barretts Esophagus With Dysplasia
  Intervention:   Device: OFDI capsule imaging
  Sponsors:   Massachusetts General Hospital;   National Institutes of Health (NIH);   National Cancer Institute (NCI)
  Recruiting
• Activated Vitamin D for the Prevention and Treatment of Acute Kidney Injury

  NCT02962102

  Conditions:   Critically Ill;   Acute Kidney Injury
  Interventions:   Drug: Calcifediol;   Drug: Calcitriol;   Drug: Placebos
  Sponsors:   David Leaf;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
  Recruiting
• An Adjunctive Family Intervention for Individual Posttraumatic Stress Disorder Treatment

  NCT02956434

  Condition:   Posttraumatic Neuroses
  Intervention:   Behavioral: Brief Family Intervention
  Sponsor:   VA Office of Research and Development
  Recruiting
• Pilot Study for TCE Imaging of the Esophagus Using an OFDI Capsule With a Compact Imaging System

  NCT02947971

  Condition:   Barrett's Esophagus
  Intervention:   Device: Experimental OFDI Imaging
  Sponsors:   Massachusetts General Hospital;   National Institutes of Health (NIH);   National Cancer Institute (NCI)
  Recruiting
• A Study of Lorlatinib in Advanced ALK and ROS1 Rearranged Lung Cancer With CNS Metastasis in the Absence of Measurable Extracranial Lesions

  NCT02927340

  Condition:   Non-Small Cell Lung Cancer (NSCLC)
  Intervention:   Drug: Lorlatinib
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Real-Time Assessment Of Breast Cancer Lumpectomy Specimen Margins With Nonlinear Microscopy

  NCT02926729

  Condition:   Breast Cancer
  Interventions:   Device: nonlinear microscopy imaging of excised surgical margins;   Procedure: standard lumpectomy without nonlinear microscopy imaging
  Sponsors:   Dana-Farber Cancer Institute;   Massachusetts Institute of Technology
  Recruiting
• Predicting Rehabilitation Outcomes in Bilingual Aphasia Using Computational Modeling

  NCT02916524

  Condition:   Aphasia
  Intervention:   Behavioral: Semantic Feature Analysis (SFA)
  Sponsors:   Boston University Charles River Campus;   National Institute on Deafness and Other Communication Disorders (NIDCD)
  Recruiting
• Bright Light Therapy for Non-motor Symptoms in Parkinson's Disease

  NCT02909192

  Condition:   Parkinson's Disease
  Intervention:   Device: Light Therapy Device
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Interdisciplinary Study of A Novel Anticonvulsant in Alcoholism

  NCT02901041

  Condition:   Alcohol Dependence
  Interventions:   Drug: Zonisamide;   Behavioral: Take Control;   Drug: Placebo (for Zonisamide)
  Sponsors:   Boston University Charles River Campus;   Mclean Hospital;   University of Houston
  Recruiting
• Family Engagement in Safety Reporting

  NCT02877017

  Condition:   Family Reported Errors and Adverse Events
  Intervention:   Behavioral: Family safety reporting intervention
  Sponsor:   Boston Children’s Hospital
  Recruiting
• A Study of LY2606368 (Prexasertib) in Patients With Solid Tumors With Replicative Stress or Homologous Repair Deficiency

  NCT02873975

  Condition:   Advanced Cancers
  Intervention:   Drug: LY2606368
  Sponsor:   Dana-Farber Cancer Institute
  Recruiting
• Trial To Test Safety And Efficacy Of Vaccination For Incurable HPV 16-Related Oropharyngeal, Cervical And Anal Cancer

  NCT02865135

  Conditions:   Cancer of Head and Neck;   Cancer of Cervix;   Cancer of Anus
  Intervention:   Drug: DPX-E7 vaccine
  Sponsors:   Dana-Farber Cancer Institute;   Stand Up To Cancer
  Recruiting
• Minimizing ICU Neurological Dysfunction With Dexmedetomidine-induced Sleep

  NCT02856594

  Conditions:   Postoperative Delirium;   Sleep;   Anesthesia
  Interventions:   Drug: Dexmedetomidine;   Drug: Placebo
  Sponsors:   Massachusetts General Hospital;   National Institute on Aging (NIA)
  Recruiting
• Effect of Nitric Oxide in Cardiac Surgery Patients With Endothelial Dysfunction.

  NCT02836899

  Condition:   Acute Kidney Injury
  Interventions:   Drug: Nitric Oxide;   Other: Placebo
  Sponsors:   Massachusetts General Hospital;   Ichinose, Fumito, M.D., Ph.D., Massachusetts General Hospital;   Kenneth, Shelton, M.D., Massachusetts General Hospital;   Kacmarek, Robert M., Ph.D., Massachusetts General Hospital;   Sundt, Thoralf M., M.D., Massachusetts General Hospital;   Villavicencio-Theoduloz, Mauricio A., M.D., Massachusetts General Hospital;   Thompson, Boyd Taylor, M.D., Massachusetts General Hospital;   Bonventre, Joseph V., M.D., Brigham Women Hospital;   Shann, Kenneth G., Massachusetts General Hospital;   Zapol, Warren M., M.D.;   Marrazzo, Francesco, M.D., Massachusetts General Hospital;   Spina, Stefano, M.D., Massachusetts General Hospital;   Zadek, Francesco, M.D., Massachusetts General Hospital;   Rezoagli, Emanuele, M.D., Massachusetts General Hospital;   National Heart, Lung, and Blood Institute (NHLBI)
  Recruiting
• Impact of Smoking and Its Cessation on Systemic and Airway Immune Activation

  NCT02836067

  Conditions:   HIV;   Smoking
  Interventions:   Behavioral: Counseling;   Other: Smoking Cessation drugs;   Procedure: Bronchoscopy;   Procedure: Blood Draw;   Behavioral: Questionnaires
  Sponsors:   Boston Medical Center;   National Institute on Drug Abuse (NIDA)
  Recruiting
• Influence of Lumbar Ultrasound on Resident Learning Curve for Lateral Labor Epidural Placement

  NCT02826668

  Conditions:   Labor Epidural;   Lumbar Ultrasound
  Intervention:   Other: Ultrasound
  Sponsor:   Brigham and Women's Hospital
  Recruiting
• A Study Of Blinatumomab For The Treatment Of Relapsed Or Refractory Indolent Non-Hodgkin Lymphoma

  NCT02811679

  Condition:   Non-Hodgkin Lymphoma
  Intervention:   Drug: Blinatumomab
  Sponsors:   Massachusetts General Hospital;   Amgen
  Recruiting
• Effect of Sclerotherapy on Fistulas and Sinus Tracts in Hidradenitis Suppurativa

  NCT02805595

  Condition:   Hidradenitis Suppurativa
  Interventions:   Drug: 23.4% Hypertonic saline;   Drug: Saline
  Sponsor:   Beth Israel Deaconess Medical Center
  Recruiting
• Improving Psychosocial Functioning in Older Veterans With PTSD

  NCT02803125

  Condition:   Posttraumatic Stress Disorder
  Interventions:   Behavioral: Psychosocial intervention;   Behavioral: Support group control
  Sponsor:   VA Office of Research and Development
  Recruiting