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• A Study to Assess the Efficacy, Safety and Tolerability of KPL-716 in Reducing Pruritus in Chronic Pruritic Diseases

  NCT03858634

  Conditions:   Pruritus;   Chronic Idiopathic Urticaria;   Chronic Idiopathic Pruritus;   Lichen Planus;   Lichen Simplex Chronicus;   Plaque Psoriasis
  Interventions:   Drug: KPL-716;   Drug: Placebo
  Sponsor:   Kiniksa Pharmaceuticals, Ltd.
  Recruiting
• Study of Efficacy and Safety of Investigational Treatments in Patients With Moderate to Severe Hidradenitis Suppurativa

  NCT03827798

  Condition:   Hidradenitis Suppurativa
  Interventions:   Drug: CFZ533;   Drug: Placebo to CFZ533;   Drug: LYS006;   Drug: Placebo to LYS006
  Sponsor:   Novartis Pharmaceuticals
  Recruiting
• A Phase 2b Study of the Efficacy, Safety, and Tolerability of M1095 in Subjects With Moderate to Severe Psoriasis

  NCT03384745

  Condition:   Psoriasis
  Interventions:   Drug: M1095;   Drug: Placebo;   Drug: Secukinumab
  Sponsors:   Bond Avillion 2 Development LP;   Avillion LLP
  Recruiting
• 2a Study to Assess the Efficacy and Safety of REGN3500 Monotherapy and Combination of REGN3500 Plus Dupilumab in Adult Patients With Moderate-to-Severe Atopic Dermatitis

  NCT03736967

  Condition:   Atopic Dermatitis
  Interventions:   Drug: REGN3500;   Drug: Dupilumab;   Drug: REGN3500 + Dupilumab Combo;   Drug: Placebo
  Sponsors:   Regeneron Pharmaceuticals;   Sanofi
  Recruiting
• A Study of MD-7246 to Treat Abdominal Pain in Patients With Diarrhea-predominant Irritable Bowel Syndrome

  NCT03931785

  Condition:   Irritable Bowel Syndrome With Diarrhea (IBS-D)
  Interventions:   Drug: MD-7246;   Drug: Placebo
  Sponsors:   Ironwood Pharmaceuticals, Inc.;   Allergan Sales, LLC
  Recruiting
• Evaluation of Safety and Efficacy of Avacopan in Subjects With Moderate to Severe Hidradenitis Suppurativa

  NCT03852472

  Conditions:   Hidradenitis Suppurativa;   Acne Inversa
  Interventions:   Drug: Avacopan;   Other: Placebo
  Sponsor:   ChemoCentryx
  Recruiting
• A Study to Assess the Efficacy, Safety, and Tolerability of KPL-716 in Reducing Pruritus in Prurigo Nodularis

  NCT03816891

  Conditions:   Prurigo Nodularis;   Pruritis
  Interventions:   Drug: KPL-716;   Drug: Placebo
  Sponsor:   Kiniksa Pharmaceuticals, Ltd.
  Recruiting
• Study Evaluating Efficacy and Safety of PF-04965842 and Dupilumab in Adult Subjects With Moderate to Severe Atopic Dermatitis on Background Topical Therapy

  NCT03720470

  Conditions:   Dermatitis;   Dermatitis, Atopic;   Eczema;   Skin Diseases;   Skin Diseases, Genetic;   Genetic Diseases, Inborn;   Skin Diseases, Eczematous;   Hypersensitivity;   Hypersensitivity, Immediate;   Immune System Diseases
  Interventions:   Drug: PF-04965842 100 mg;   Drug: PF-04965842 200 mg;   Drug: Dupilumab;   Drug: Oral Placebo;   Drug: Injectable Placebo
  Sponsor:   Pfizer
  Recruiting
• Effects of Pneumatic Vitreolysis on Macular Hole

  NCT03677869

  Conditions:   Vitreomacular Traction (VMT);   and Full-thickness Macular Holes (MH)
  Intervention:   Device: Intraocular gas (C3F8)
  Sponsors:   Jaeb Center for Health Research;   National Institutes of Health (NIH);   National Eye Institute (NEI)
  Recruiting
• A Study of DCC-2618 vs Sunitinib in Advanced GIST Patients After Treatment With Imatinib

  NCT03673501

  Condition:   Gastrointestinal Stromal Tumors
  Interventions:   Drug: DCC-2618;   Drug: Sunitinib
  Sponsor:   Deciphera Pharmaceuticals LLC
  Recruiting
• XEN-45 Gel Stent Versus Trabeculectomy in Glaucoma: Gold-Standard Pathway Study (GPS)

  NCT03654885

  Condition:   Glaucoma
  Interventions:   Device: XEN group;   Procedure: Trabeculectomy
  Sponsor:   Allergan
  Recruiting
• Effects of Pneumatic Vitreolysis on Vitreomacular Traction

  NCT03647267

  Condition:   Vitreomacular Traction
  Interventions:   Device: Pneumatic Vitreolysis (C3F8 injection);   Other: Observation
  Sponsors:   Jaeb Center for Health Research;   National Institutes of Health (NIH);   National Eye Institute (NEI)
  Recruiting
• A Study Investigating the Efficacy, Safety, and PK Profile of ANB020 Administered to Adult Subjects With Moderate-to-Severe AD

  NCT03533751

  Condition:   Atopic Dermatitis
  Interventions:   Biological: etokimab (ANB020);   Drug: Placebo
  Sponsor:   AnaptysBio, Inc.
  Recruiting
• A Study of Baricitinib (LY3009104) in Adult Participants With Moderate to Severe Atopic Dermatitis

  NCT03435081

  Condition:   Atopic Dermatitis
  Interventions:   Drug: Baricitinib;   Drug: Placebo
  Sponsors:   Eli Lilly and Company;   Incyte Corporation
  Recruiting
• DRCR.Net Aflibercept vs. Bevacizumab + Deferred Aflibercept for the Treatment of CI-DME

  NCT03321513

  Condition:   Diabetic Macular Edema
  Interventions:   Drug: intravitreous aflibercept;   Drug: Bevacizumab + Deferred Aflibercept Group
  Sponsor:   Jaeb Center for Health Research
  Recruiting
• ECOSPOR III - SER-109 Versus Placebo in the Treatment of Adults With Recurrent Clostridium Difficile Infection

  NCT03183128

  Condition:   Clostridium Difficile Infection
  Interventions:   Drug: SER-109;   Drug: Placebo
  Sponsor:   Seres Therapeutics, Inc.
  Recruiting
• Efficacy and Safety of OBE2109 in Subjects With Heavy Menstrual Bleeding Associated With Uterine Fibroids

  NCT03070899

  Conditions:   Uterine Fibroids;   Heavy Menstrual Bleeding
  Interventions:   Drug: Placebo + Placebo Add-back;   Drug: OBE2109 + Placebo Add-back;   Drug: OBE2109 + Add-back
  Sponsor:   ObsEva SA
  Recruiting
• ASCENT-Study of Sacituzumab Govitecan in Refractory/Relapsed Triple-Negative Breast Cancer

  NCT02574455

  Condition:   Breast Cancer
  Interventions:   Drug: Sacituzumab govitecan;   Drug: Eribulin;   Drug: Capecitabine;   Drug: Gemcitabine;   Drug: Vinorelbine
  Sponsor:   Immunomedics, Inc.
  Recruiting
• A Study of Brentuximab Vedotin in Adults Age 60 and Above With Hodgkin Lymphoma (HL) and CD30-expressing Peripheral T-cell Lymphoma (PTCL)

  NCT01716806

  Conditions:   Hodgkin Disease;   Peripheral T Cell Lymphoma
  Interventions:   Drug: brentuximab vedotin;   Drug: bendamustine;   Drug: dacarbazine;   Drug: nivolumab
  Sponsors:   Seattle Genetics, Inc.;   Bristol-Myers Squibb
  Recruiting
• Efficacy and Safety of Oral Ibrexafungerp (SCY-078) vs. Placebo in Subjects With Acute Vulvovaginal Candidiasis

  NCT03987620

  Condition:   Candida Vulvovaginitis
  Interventions:   Drug: Ibrexafungerp;   Drug: Placebo
  Sponsors:   Scynexis, Inc.;   PPD
  Recruiting
• Dose Ranging Study to Assess Efficacy, Safety, Tolerability and Pharmacokinetics of PF-06700841 Topical Cream in Participants With Mild or Moderate Atopic Dermatitis

  NCT03903822

  Condition:   Atopic Dermatitis
  Interventions:   Drug: PF-06700841;   Drug: Vehicle (Placebo)
  Sponsor:   Pfizer
  Recruiting