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• Nature Video to Improve Older Adult Health: A Feasibility Study.

  NCT03722316

  Conditions:   Mild Dementia;   Mild Cognitive Impairment
  Interventions:   Other: Immersive Nature Video;   Other: Neutral Video
  Sponsors:   University of Southern California;   Front Porch Center for Innovation and Wellbeing
  Recruiting
• A Smartphone App to Improve Physical Activity

  NCT03417440

  Condition:   Sedentary Lifestyle
  Interventions:   Other: Physical Activity (PA) Tracker App;   Other: On Your Feet;   Other: Coach Me;   Other: Proof Positive
  Sponsors:   University of Southern California;   National Institute on Aging (NIA);   University of California, Los Angeles
  Recruiting
• A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of TAK-994 in Healthy Participants

  NCT03933488

  Condition:   Healthy Participants
  Interventions:   Drug: TAK-994;   Drug: TAK-994 Placebo
  Sponsor:   Takeda
  Recruiting
• Lu AF82422 in Healthy Non-Japanese and Japanese Subjects and in Patients With Parkinson's Disease

  NCT03611569

  Conditions:   Healthy;   Parkinson Disease
  Interventions:   Drug: Lu AF82422;   Drug: Placebo
  Sponsor:   H. Lundbeck A/S
  Recruiting
• Safety and Tolerability Study Of PF-06835375 In Subjects With Seropositive Systemic Lupus Erythematosus Or Rheumatoid Arthritis

  NCT03334851

  Conditions:   Systemic Lupus Erythematosus;   Rheumatoid Arthritis
  Interventions:   Drug: PF-06835375;   Drug: Placebo
  Sponsor:   Pfizer
  Recruiting
• DRCR.Net Aflibercept vs. Bevacizumab + Deferred Aflibercept for the Treatment of CI-DME

  NCT03321513

  Condition:   Diabetic Macular Edema
  Interventions:   Drug: intravitreous aflibercept;   Drug: Bevacizumab + Deferred Aflibercept Group
  Sponsor:   Jaeb Center for Health Research
  Recruiting
• MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study

  NCT03072927

  Condition:   Lumbar Spinal Stenosis
  Intervention:   Device: MILD
  Sponsor:   Vertos Medical, Inc.
  Recruiting
• Sustained Effect of Droxidopa in Symptomatic Neurogenic Orthostatic Hypotension

  NCT02586623

  Condition:   Symptomatic Neurogenic Orthostatic Hypotension
  Interventions:   Drug: Droxidopa capsules;   Drug: Placebo capsules
  Sponsor:   Lundbeck Northera Ltd.
  Recruiting
• Safety Follow-up Study in Subjects With Silicone Gel-filled Breast Implants as Compared Both to Saline-filled Breast Implants and to National Norms

  NCT00443274

  Condition:   Breast Implant
  Interventions:   Other: NBIR Placeholder;   Device: 410 Arm;   Device: BIFs
  Sponsor:   Allergan
  Recruiting
• Phase 3 Trial of Elacestrant vs. Standard of Care for the Treatment of Patients With ER+/HER2- Advanced Breast Cancer

  NCT03778931

  Condition:   Breast Cancer
  Interventions:   Drug: Elacestrant;   Drug: Standard of Care
  Sponsor:   Radius Pharmaceuticals, Inc.
  Recruiting
• ECG Belt for CRT Response

  NCT03504020

  Condition:   Heart Failure
  Intervention:   Device: ECG Belt Research System
  Sponsor:   Medtronic Cardiac Rhythm and Heart Failure
  Recruiting
• A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Subcutaneous Infusions of ABBV-951 in Subjects With Parkinson's Disease

  NCT03033498

  Condition:   Parkinson's Disease (PD)
  Intervention:   Drug: ABBV-951
  Sponsor:   AbbVie
  Recruiting
• A Pivotal Study of the Premia Spine TOPS™ System

  NCT03012776

  Conditions:   Lumbar Spinal Stenosis;   Degenerative Spondylolisthesis
  Interventions:   Device: Total Posterior Spine System (TOPS);   Procedure: Transforaminal Lumbar Interbody Fusion (TLIF)
  Sponsor:   Premia Spine
  Recruiting
• Safety, Tolerability, Pharmacokinetics and Activity of K0706

  NCT02629692

  Conditions:   Chronic Myeloid Leukemia (for Part B and C);   Healthy (For Part A)
  Interventions:   Drug: K0706;   Drug: Placebo
  Sponsor:   Sun Pharma Advanced Research Company Limited
  Recruiting
• Oral Factor XIa Inhibitor for the Prevention of New Ischemic Stroke in Patients Receiving Aspirin and Clopidogrel Following Acute Ischemic Stroke or Transient Ischemic Attack (TIA)

  NCT03766581

  Conditions:   Acute Ischemic Stroke;   Transient Ischemic Attack (TIA)
  Interventions:   Drug: BMS-986177;   Other: BMS-986177 Placebo;   Drug: Clopidogrel;   Drug: Aspirin
  Sponsors:   Bristol-Myers Squibb;   Janssen, LP
  Recruiting
• A Study of LY3454738 in Healthy Participants and Participants With Atopic Dermatitis

  NCT03750643

  Condition:   Dermatitis, Atopic
  Interventions:   Drug: LY3454738;   Drug: Placebo
  Sponsor:   Eli Lilly and Company
  Recruiting
• DE-117 Spectrum 5 Study

  NCT03697811

  Condition:   Primary Open-angle Glaucoma and Ocular Hypertension
  Intervention:   Drug: DE-117 Ophthalmic Solution
  Sponsor:   Santen Inc.
  Recruiting
• Efficacy and Safety Trial of Conbercept Intravitreal Injection for Neovascular Age-related Macular Degeneration (PANDA-2)

  NCT03630952

  Condition:   Neovascular Age-related Macular Degeneration
  Interventions:   Biological: 0.5 mg Conbercept Intravitreal Injection;   Biological: 1.0 mg Conbercept Intravitreal Injection;   Biological: 2.0 mg Aflibercept Intravitreal Injection
  Sponsor:   Chengdu Kanghong Biotech Co., Ltd.
  Recruiting
• Obalon Balloon System Post-Approval Study

  NCT03570034

  Condition:   Obesity
  Intervention:   Device: Obalon Balloon System
  Sponsor:   Obalon Therapeutics, Inc.
  Recruiting
• Safety and Efficacy of NYX-783 in Subjects With Post-Traumatic Stress Disorder

  NCT04044664

  Condition:   Post-Traumatic Stress Disorder
  Interventions:   Drug: Placebo oral capsule;   Drug: NYX-783
  Sponsors:   Aptinyx;   Premier Research Group plc;   Massachusetts General Hospital
  Recruiting
• Study to Evaluate the Efficacy and Safety of Adjunctive Pimavanserin in Subjects With Major Depressive Disorder and Inadequate Response to Antidepressant Treatment (CLARITY-2)

  NCT03968159

  Condition:   Adjunctive Treatment of Major Depressive Disorder
  Interventions:   Drug: Pimavanserin;   Drug: Placebo
  Sponsor:   ACADIA Pharmaceuticals Inc.
  Recruiting
• A Study of the Effect and Safety of Sparsentan in the Treatment of Patients With IgA Nephropathy

  NCT03762850

  Condition:   Immunoglobulin A Nephropathy
  Interventions:   Drug: sparsentan;   Drug: irbesartan
  Sponsor:   Retrophin, Inc.
  Recruiting
• QUILT-2.023: A Study of ALT-803, a Fusion Protein Activator of Natural Killer and T-Cells, in Combination With Pembrolizumab vs Pembrolizumab Alone as First-Line Treatment for Patients With Metastatic NSCLC.

  NCT03520686

  Condition:   Non Small Cell Lung Cancer
  Interventions:   Drug: ALT-803 + Pembrolizumab;   Drug: Pembrolizumab
  Sponsors:   Altor BioScience;   NantCell, Inc.
  Recruiting
• QUILT-3.055: A Study of ALT-803 in Combination With PD-1/PD-L1 Checkpoint Inhibitor in Patients With Advanced Cancer

  NCT03228667

  Conditions:   Non-Small Cell Lung Cancer;   Small Cell Lung Cancer;   Urothelial Carcinoma;   Head and Neck Squamous Cell Carcinoma;   Merkel Cell Carcinoma;   Melanoma;   Renal Cell Carcinoma;   Gastric Cancer;   Cervical Cancer;   Hepatocellular Carcinoma;   Microsatellite Instability;   Mismatch Repair Deficiency;   Colorectal Cancer
  Interventions:   Drug: ALT-803 + Pembrolizumab;   Drug: ALT-803 + Nivolumab;   Drug: ALT-803 + Atezolizumab;   Drug: ALT-803 + Avelumab
  Sponsor:   Altor BioScience
  Recruiting
• A Clinical Effectiveness Study Examining the Efficacy and Safety of ONS-5010 in Subjects With Neovascular Age-related Macular Degeneration (AMD)

  NCT03834753

  Conditions:   Age-related Macular Degeneration;   Neovascular Age-related Macular Degeneration;   Wet Macular Degeneration
  Interventions:   Biological: bevacizumab;   Biological: ranibizumab
  Sponsor:   Outlook Therapeutics, Inc.
  Recruiting
• A Study to Evaluate the Efficacy of SAGE-217 in the Treatment of Adult Subjects With Major Depressive Disorder

  NCT03672175

  Condition:   Major Depressive Disorder
  Interventions:   Drug: SAGE-217;   Drug: Placebo
  Sponsor:   Sage Therapeutics
  Recruiting
• Long-term Safety and Efficacy Extension Trial of Bimatoprost SR

  NCT03891446

  Conditions:   Open-Angle Glaucoma;   Ocular Hypertension
  Intervention:   Drug: Bimatoprost SR
  Sponsor:   Allergan
  Recruiting
• Comparison of Bimatoprost SR to Selective Laser Trabeculoplasty in Patients With Open-Angle Glaucoma or Ocular Hypertension

  NCT02507687

  Conditions:   Glaucoma, Open-Angle;   Ocular Hypertension
  Interventions:   Drug: Bimatoprost SR;   Drug: Sham Bimatoprost SR;   Procedure: Selective Laser Trabeculoplasty;   Procedure: Sham Selective Laser Trabeculoplasty
  Sponsor:   Allergan
  Recruiting
• Persistence of Effect and Safety of Valbenazine for the Treatment of Tardive Dyskinesia

  NCT03891862

  Condition:   Tardive Dyskinesia (TD)
  Interventions:   Drug: Valbenazine;   Drug: Placebo oral capsule
  Sponsor:   Neurocrine Biosciences
  Recruiting
• Strategic Management to Optimize Response To Cardiac Resynchronization Therapy

  NCT03089281

  Condition:   Heart Failure
  Intervention:   Device: CRT-D
  Sponsor:   Boston Scientific Corporation
  Recruiting
• A 24-Month Study to Evaluate the Efficacy and Safety of Elenbecestat (E2609) in Subjects With Early Alzheimer's Disease_

  NCT03036280

  Condition:   Alzheimer's Disease
  Interventions:   Drug: Elenbecestat (E2609);   Drug: Placebo
  Sponsors:   Eisai Co., Ltd.;   Biogen
  Recruiting
• Tenecteplase in Stroke Patients Between 4 and 24 Hours

  NCT03785678

  Condition:   THROMBOLYSIS
  Interventions:   Biological: Tenecteplase;   Other: Placebo
  Sponsor:   Genentech, Inc.
  Recruiting
• Safety and Efficacy of KPI-121 in Subjects With DED

  NCT03616899

  Condition:   Kerato Conjunctivitis Sicca
  Interventions:   Drug: KPI-121 Ophthalmic Suspension;   Drug: Vehicle
  Sponsor:   Kala Pharmaceuticals, Inc.
  Recruiting
• Lacripep™ in Subjects With Dry Eye Associated With Primary Sjögren's Syndrome

  NCT03226444

  Conditions:   Primary Sjögren Syndrome;   Dry Eye
  Interventions:   Drug: 0.005% Lacripep;   Drug: 0.01% Lacripep;   Drug: Placebo
  Sponsor:   TearSolutions, Inc.
  Recruiting
• A Cariprazine Study in the Prevention of Relapse in Bipolar I Disorder Patients Whose Current Episode is Manic or Depressive, With or Without Mixed Features

  NCT03573297

  Conditions:   Bipolar I Disorder;   Mania;   Depression
  Interventions:   Drug: Cariprazine;   Drug: Placebo
  Sponsor:   Forest Laboratories
  Recruiting
• A Study to Evaluate the Effect of Testosterone Replacement Therapy (TRT) on the Incidence of Major Adverse Cardiovascular Events (MACE) and Efficacy Measures in Hypogonadal Men ( TRAVERSE )

  NCT03518034

  Conditions:   Hypogonadism;   Cardiovascular Diseases
  Interventions:   Drug: Testosterone;   Drug: Placebo
  Sponsors:   AbbVie;   Acerus Pharmaceuticals Corporation;   Allergan Sales, LLC;   Endo Pharmaceuticals;   Upsher-Smith Laboratories
  Recruiting
• Talazoparib For Neoadjuvant Treatment Of Germline Brca1/2 Mutation Patients With Early Triple-negative Breast Cancer

  NCT03499353

  Condition:   Early Breast Cancer
  Intervention:   Drug: TALAZOPARIB
  Sponsor:   Pfizer
  Recruiting
• Safety and Efficacy Study of Gantenerumab in Participants With Early Alzheimer's Disease (AD)

  NCT03443973

  Condition:   Alzheimer's Disease
  Interventions:   Drug: Gantenerumab;   Drug: Placebo
  Sponsor:   Hoffmann-La Roche
  Recruiting
• A Phase II Study of M2951 in Systemic Lupus Erythematosus (SLE)

  NCT02975336

  Condition:   Systemic Lupus Erythematosus
  Interventions:   Drug: Placebo;   Drug: M2951
  Sponsors:   EMD Serono Research & Development Institute, Inc.;   Merck KGaA, Darmstadt, Germany
  Recruiting
• Anemia Studies in Chronic Kidney Disease: Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor Daprodustat-Non-Dialysis (ASCEND-ND)

  NCT02876835

  Condition:   Anaemia
  Interventions:   Drug: Daprodustat;   Drug: Darbepoetin alfa;   Drug: Placebo;   Drug: Iron Therapy
  Sponsor:   GlaxoSmithKline
  Recruiting
• A Long-term Safety Study of Esketamine Nasal Spray in Treatment-resistant Depression

  NCT02782104

  Condition:   Depressive Disorder, Treatment-Resistant
  Intervention:   Drug: Esketamine Nasal Spray
  Sponsor:   Janssen Research & Development, LLC
  Recruiting
• Long Term, Extension Study of the Safety and Efficacy of AVP-786 for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type

  NCT02446132

  Condition:   Agitation in Patients With Dementia of the Alzheimer's Type
  Intervention:   Drug: AVP-786
  Sponsor:   Avanir Pharmaceuticals
  Recruiting
• Efficacy and Safety Study to Evaluate Vadadustat for the Maintenance Treatment of Anemia in Subjects With Non-dialysis-dependent Chronic Kidney Disease (NDD-CKD)

  NCT02680574

  Conditions:   Anemia;   Non-dialysis-dependent Chronic Kidney Disease
  Interventions:   Drug: vadadustat;   Drug: darbepoetin alfa
  Sponsor:   Akebia Therapeutics
  Recruiting
• Efficacy and Safety Study to Evaluate Vadadustat for the Correction of Anemia in Subjects With Non-dialysis-dependent Chronic Kidney Disease (NDD-CKD)

  NCT02648347

  Conditions:   Anemia;   Non-dialysis-dependent Chronic Kidney Disease
  Interventions:   Drug: vadadustat;   Drug: darbepoetin alfa
  Sponsor:   Akebia Therapeutics
  Recruiting
• Baroreflex Activation Therapy for Heart Failure

  NCT02627196

  Condition:   Heart Failure
  Interventions:   Device: BAROSTIM NEO® System;   Drug: Medical Management
  Sponsor:   CVRx, Inc.
  Recruiting
• Safety and Effectiveness of Belimumab in Systemic Lupus Erythematosus Registry

  NCT01729455

  Condition:   Systemic Lupus Erythematosus
  Interventions:   Biological: BENLYSTA;   Other: SLE treatment
  Sponsors:   Human Genome Sciences Inc., a GSK Company;   GlaxoSmithKline
  Recruiting
• Vision Testing in Patients With Partial Seizures Receiving Either Lyrica or Placebo

  NCT00351611

  Condition:   Epilepsies, Partial
  Interventions:   Drug: Lyrica (pregabalin);   Drug: placebo
  Sponsor:   Pfizer
  Recruiting
• A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements

  NCT03093116

  Conditions:   Locally Advanced Solid Tumors;   Metastatic Solid Tumors
  Intervention:   Drug: Oral repotrectinib (TPX-0005)
  Sponsor:   Turning Point Therapeutics, Inc.
  Recruiting
• A Phase III Study Assessing the Efficacy and Safety of DE-117 Ophthalmic Solution Compared With Timolol Maleate Ophthalmic Solution 0.5% in Subjects With Glaucoma or Ocular Hypertension - Spectrum 4 Study

  NCT03691662

  Condition:   Glaucoma and Ocular Hypertension
  Interventions:   Drug: DE-117 Ophthalmic Solution;   Drug: Timolol Maleate Ophthalmic Solution 0.5%
  Sponsor:   Santen Inc.
  Recruiting
• A Study of Ustekinumab in Participants With Active Systemic Lupus Erythematosus

  NCT03517722

  Condition:   Lupus Erythematosus, Systemic
  Interventions:   Drug: Placebo;   Drug: Ustekinumab (approximately 6 mg/kg);   Drug: Ustekinumab 90 mg
  Sponsor:   Janssen Research & Development, LLC
  Recruiting
• Evaluate TV-46000 as Maintenance Treatment in Adult and Adolescent Patients With Schizophrenia

  NCT03503318

  Condition:   Schizophrenia
  Interventions:   Drug: TV-46000 - A;   Drug: TV-46000 - B;   Drug: Placebo
  Sponsor:   Teva Branded Pharmaceutical Products, R&D Inc.
  Recruiting
• Safety and Efficacy of TRx0237 in Subjects With Early Alzheimer's Disease

  NCT03446001

  Condition:   Alzheimer Disease
  Interventions:   Drug: TRx0237 8 mg/day;   Drug: Placebo;   Drug: TRx0237 16 mg/day
  Sponsor:   TauRx Therapeutics Ltd
  Recruiting
• A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)

  NCT01351545

  Conditions:   Hematologic Malignancies;   Inherited Disorders of Metabolism;   Inherited Abnormalities of Platelets;   Histiocytic Disorders;   Acute Myelogenous Leukemia (AML or ANLL);   Acute Lymphoblastic Leukemia (ALL);   Other Acute Leukemia;   Chronic Myelogenous Leukemia (CML);   Myelodysplastic (MDS) / Myeloproliferative (MPN) Diseases;   Other Leukemia;   Hodgkin Lymphoma;   Non-hodgkin Lymphoma;   Multiple Myeloma/ Plasma Cell Disorder (PCD);   Inherited Abnormalities of Erythrocyte Differentiation or Function;   Disorders of the Immune System;   Automimmune Diseases;   Severe Aplastic Anemia
  Intervention:   Drug: A multicenter access and distribution protocol for unlicensed cryopreserved cord blood units (CBUs)
  Sponsors:   Center for International Blood and Marrow Transplant Research;   National Marrow Donor Program
  Recruiting