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• Digital Home Blood Pressure Monitoring in Type B Aortic Dissection Patients

  NCT04116684

  Conditions:   Aortic Dissection;   Hypertension
  Intervention:   Device: Withings Digital Blood Pressure Monitor
  Sponsor:   The Cleveland Clinic
  Recruiting
• Self-Management in Parents of Technology-Dependent Children

  NCT04105244

  Conditions:   Caregivers;   Parents;   Self-Management;   Chronic Illnesses, Multiple
  Intervention:   Behavioral: Resourcefulness Training©
  Sponsor:   University Hospitals Cleveland Medical Center
  Recruiting
• Peripheral Blood Mononuclear Cells Response In Healthy Controls, Heavy Drinkers, and Patients With Alcoholic Hepatitis

  NCT04088370

  Condition:   Alcoholic Hepatitis
  Intervention:   Other: Blood Draw
  Sponsor:   The Cleveland Clinic
  Recruiting
• S-Nitrosylation (SNO) Therapy During Autologous Blood Transfusion

  NCT03999229

  Condition:   Transfusion Related Complication
  Interventions:   Drug: SNO;   Drug: Normal Saline;   Drug: Red Blood Cell
  Sponsors:   James Reynolds;   Case Western Reserve University;   National Heart, Lung, and Blood Institute (NHLBI)
  Recruiting
• GSNOR Phenotyping/GSNO Challenge

  NCT03926741

  Conditions:   Asthma;   Healthy Volunteers
  Intervention:   Drug: GSNO
  Sponsors:   James Reynolds;   University Hospitals Cleveland Medical Center;   Case Western Reserve University;   National Heart, Lung, and Blood Institute (NHLBI)
  Recruiting
• Simple Fall-Arrest Harness vs. Adjustable Harness

  NCT03651297

  Conditions:   Fall Accident;   Fall Injury;   Balancing Interference
  Interventions:   Other: Balance training with Fall-Arrest harness;   Other: Balance training with Adjustable harness
  Sponsor:   Cleveland State University
  Recruiting
• Computerized Vestibular Rehabilitation

  NCT03589859

  Condition:   Vestibular Diseases
  Intervention:  
  Sponsor:   VA Office of Research and Development
  Recruiting
• Monocyte Biomarkers in Moderate to Severe Plaque Psoriasis Subjects Treated With Apremilast

  NCT03442088

  Condition:   Plaque Psoriasis
  Intervention:   Drug: Apremilast
  Sponsor:   University Hospitals Cleveland Medical Center
  Recruiting
• Feasibility of a Social Media-based Weight Loss Program for Low Socioeconomic Status Individuals

  NCT03337230

  Condition:   Obesity
  Interventions:   Behavioral: Physical Activity;   Behavioral: Diet;   Behavioral: Social Support
  Sponsor:   Case Comprehensive Cancer Center
  Recruiting
• Getting Ahead for Cancer Control

  NCT03247634

  Condition:   Cancer Prevention
  Intervention:   Behavioral: Getting Ahead in a Just-Gettin'-By World
  Sponsor:   Case Comprehensive Cancer Center
  Recruiting
• Ethanol Induces Skeletal Muscle Autophagy

  NCT03209791

  Condition:   Alcoholic Liver Disease
  Intervention:   Other: Biopsies
  Sponsor:   The Cleveland Clinic
  Recruiting
• Mechanisms of Malnutrition in Cirrhosis With Portosystemic Shunting

  NCT03121404

  Condition:   Cirrhosis
  Intervention:   Procedure: Rectus abdominis muscle biopsy
  Sponsor:   The Cleveland Clinic
  Recruiting
• Cytoscopic Antibiotic Irrigant to Reduce Postoperative Urinary Tract Infection

  NCT03099863

  Condition:   Urinary Tract Infections
  Interventions:   Drug: Cystoscopic Fluid containing Neosporin G. U. Irrigant;   Procedure: Cystoscopy;   Drug: Cystoscopic Fluid/Placebo
  Sponsor:   MetroHealth Medical Center
  Recruiting
• Enhancing Quitline Services for African American Smokers

  NCT03064971

  Condition:   Tobacco Use Cessation
  Interventions:   Behavioral: Standard Care;   Behavioral: smoking cessation DVD;   Behavioral: PTF DVD
  Sponsors:   Case Comprehensive Cancer Center;   American Cancer Society, Inc.;   Alere Wellbeing;   North Carolina Tobacco Quitline
  Recruiting
• Individualizing Disease Prevention for Middle-Aged Adults

  NCT03023813

  Condition:   Primary Health Care
  Intervention:   Other: Intervention
  Sponsor:   Glen Taksler
  Recruiting
• Cleveland Heart and Metabolic Prevention Study

  NCT03012022

  Condition:   Heart Failure Risk Factors in Healthy Individuals
  Intervention:  
  Sponsors:   The Cleveland Clinic;   National Heart, Lung, and Blood Institute (NHLBI)
  Recruiting
• Online Information and Support for Distance Caregivers

  NCT02666183

  Condition:   Advanced Cancer
  Interventions:   Behavioral: Video-C;   Behavioral: Nurse Coaching;   Behavioral: Web-Only
  Sponsor:   Case Comprehensive Cancer Center
  Recruiting
• DISCOVER Study: Microscope-integrated Intraoperative OCT Study

  NCT02423213

  Conditions:   Retinal Diseases;   Fuchs Endothelial Dystrophy;   Macular Hole;   Epiretinal Membrane;   Retinal Detachment
  Intervention:  
  Sponsors:   The Cleveland Clinic;   National Eye Institute (NEI)
  Recruiting
• Genetics of Uveitis

  NCT02357238

  Conditions:   Uveitis;   Infectious Uveitis
  Intervention:  
  Sponsor:   The Cleveland Clinic
  Recruiting
• Effects of Donepezil HCL on Task-Activated fMRI Brain Activation in Healthy Older Adults at Genetic Risk for Alzheimer's Disease

  NCT02087865

  Condition:   Genetic Risk for Alzheimer's Disease
  Interventions:   Drug: donepezil HCL;   Drug: Placebo
  Sponsors:   The Cleveland Clinic;   National Institute on Aging (NIA)
  Recruiting
• Analysis of Anterior Chamber Inflammation by Optical Coherence Tomography

  NCT01746537

  Condition:   Uveitis
  Intervention:  
  Sponsor:   The Cleveland Clinic
  Recruiting
• Asthma Inflammation Research

  NCT01536522

  Conditions:   Asthma;   Allergic Asthma;   Non-allergic Asthma
  Interventions:   Dietary Supplement: Nutritional approach for asthma;   Dietary Supplement: Low Caloric Shake;   Biological: whole lung allergen challenge
  Sponsor:   The Cleveland Clinic
  Recruiting
• Biospecimen Repository for Cardiac Arrhythmias at the Cleveland Clinic

  NCT00921986

  Condition:   Arrhythmias, Cardiac
  Intervention:  
  Sponsor:   The Cleveland Clinic
  Recruiting
• Effects of Semaglutide in HIV-Associated Lipohypertrophy

  NCT04019197

  Conditions:   HIV/AIDS;   Lipohypertrophy;   Obesity
  Interventions:   Drug: Semaglutide Injectable Product;   Drug: Placebo
  Sponsors:   Case Western Reserve University;   Medical University of South Carolina;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
  Recruiting
• Peripheral Nerve Stimulation(PNS) for Subacromial Impingement Syndrome(SIS)

  NCT03752619

  Conditions:   Shoulder Pain;   Shoulder Impingement Syndrome;   Shoulder Tendinitis;   Shoulder Bursitis;   Pain, Shoulder
  Interventions:   Device: Contracting Producing Peripheral Nerve Stimulation;   Device: Non Contracting Producing Peripheral Nerve Stimulation;   Other: Physical Therapy
  Sponsors:   MetroHealth Medical Center;   Vanderbilt University
  Recruiting
• A Lay-Led Intervention for War and Refugee Related Trauma

  NCT03502278

  Condition:   PTSD
  Intervention:   Behavioral: Islamic Trauma Healing
  Sponsors:   University of Washington;   National Institute of Mental Health (NIMH);   Seattle Pacific University;   Case Western Reserve University
  Recruiting
• Belun Ring Validation Study for Assessment of Obstructive Sleep Apnea

  NCT03997916

  Condition:   Obstructive Sleep Apnea
  Interventions:   Device: Belun Ring;   Diagnostic Test: PSG
  Sponsors:   University Hospitals Cleveland Medical Center;   Belun Technology Company Limited
  Recruiting
• Improving SCI Rehabilitation Interventions by Retraining the Brain

  NCT03892746

  Condition:   Cervical Spinal Cord Injruy
  Interventions:   Device: Active tDCS + task oriented practice;   Device: Sham tDCS + task oriented practice
  Sponsors:   The Cleveland Clinic;   United States Department of Defense
  Recruiting
• Interstitial Cystitis: Examination of the Central Autonomic Network

  NCT03008382

  Conditions:   Interstitial Cystitis/Painful Bladder Syndrome;   Myofascial Pelvic Pain
  Interventions:   Drug: Metoprolol Tartrate Oral Tablet;   Drug: Placebo Oral Tablet
  Sponsors:   Medical College of Wisconsin;   NorthShore University HealthSystem;   Case Western Reserve University
  Recruiting
• Multicenter Imaging in Lead Extraction Study

  NCT03772704

  Condition:   Mechanical Complication of Cardiac Electronic Device
  Intervention:  
  Sponsors:   The Cleveland Clinic;   Philips Healthcare
  Recruiting
• MS PATHS Normative Sub-Study

  NCT02996084

  Condition:   Healthy Volunteer
  Intervention:  
  Sponsor:   Biogen
  Recruiting
• Lifestyle Intervention in Preparation for Pregnancy (LIPP)

  NCT03146156

  Conditions:   Obesity;   Lifestyle-related Condition;   Macrosomia, Fetal
  Intervention:   Behavioral: Lifestyle Intervention
  Sponsors:   Tufts Medical Center;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   Pennington Biomedical Research Center;   The Cleveland Clinic;   MetroHealth Medical Center;   Massachusetts General Hospital
  Recruiting
• Sickle Cell Disease, Hemechip

  NCT03948516

  Condition:   Sickle Cell Disease
  Intervention:   Device: HemeChip
  Sponsors:   University Hospitals Cleveland Medical Center;   US federal government;   Amino Kano Teaching Hospital;   Murtala Mohammed Specialist Hospital;   Hasiya Bayero Pediatric Hospital;   University of Nebraska;   University of North Carolina, Chapel Hill;   Case Western Reserve University
  Recruiting
• A Study to Evaluate the Safety and Efficacy of MEDI8897 for the Prevention of Medically Attended RSV LRTI in Healthy Late Preterm and Term Infants

  NCT03979313

  Condition:   Respiratory Syncytial Virus Infections
  Interventions:   Drug: MEDI8897;   Drug: Placebo
  Sponsor:   MedImmune LLC
  Recruiting
• Combination Chemotherapy With or Without Blinatumomab in Treating Patients With Newly Diagnosed BCR-ABL-Negative B Lineage Acute Lymphoblastic Leukemia

  NCT02003222

  Conditions:   Acute Lymphoblastic Leukemia;   B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative
  Interventions:   Procedure: Allogeneic Hematopoietic Stem Cell Transplantation;   Biological: Blinatumomab;   Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: Daunorubicin Hydrochloride;   Drug: Dexamethasone;   Drug: Etoposide;   Other: Laboratory Biomarker Analysis;   Drug: Mercaptopurine;   Drug: Methotrexate;   Drug: Pegaspargase;   Drug: Prednisone;   Biological: Rituximab;   Drug: Vincristine Sulfate
  Sponsors:   National Cancer Institute (NCI);   Canadian Cancer Trials Group
  Recruiting
• North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)

  NCT01694940

  Conditions:   Mitochondrial Disorders;   Mitochondrial Genetic Disorders;   Mitochondrial Diseases;   Disorder of Mitochondrial Respiratory Chain Complexes;   Deletion and Duplication of Mitochondrial DNA
  Intervention:  
  Sponsors:   Columbia University;   National Institute of Neurological Disorders and Stroke (NINDS)
  Recruiting
• Evaluation of the Precision and Sensitivity of Tilmanocept Uptake Value (TUV) on Tc 99m Tilmanocept Planar Imaging

  NCT03938636

  Condition:   Rheumatoid Arthritis
  Intervention:   Drug: TC99m-tilmanocept
  Sponsor:   Navidea Biopharmaceuticals
  Recruiting
• Safety and Tolerability of M254 in Healthy Volunteers and Immune Thrombocytopenic Purpura (ITP) Patients

  NCT03866577

  Condition:   Immune Thrombocytopenic Purpura (ITP)
  Interventions:   Biological: Biological: M254;   Drug: Placebo;   Biological: Intravenous immunoglobulin (IVIg)
  Sponsor:   Momenta Pharmaceuticals, Inc.
  Recruiting
• Alcoholic Hepatitis Network Observational Study

  NCT03850899

  Condition:   Alcoholic Hepatitis
  Intervention:  
  Sponsors:   Indiana University;   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
  Recruiting
• Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults With Blood Cancers Undergoing Donor Stem Cell Transplant

  NCT03779854

  Conditions:   Acute Biphenotypic Leukemia;   Acute Leukemia;   Acute Leukemia of Ambiguous Lineage;   Acute Lymphoblastic Leukemia;   Acute Undifferentiated Leukemia;   Allogeneic Hematopoietic Stem Cell Transplantation Recipient;   Blastic Plasmacytoid Dendritic Cell Neoplasm;   Blasts Under 25 Percent of Bone Marrow Nucleated Cells;   Blasts Under 5 Percent of Bone Marrow Nucleated Cells;   Mixed Phenotype Acute Leukemia;   Myelodysplastic Syndrome With Excess Blasts-1;   Myelodysplastic Syndrome With Excess Blasts-2
  Interventions:   Radiation: Total-Body Irradiation;   Drug: Thiotepa;   Drug: Fludarabine;   Drug: Cyclophosphamide;   Drug: Busulfan;   Biological: Allogeneic Hematopoietic Stem Cell Transplantation (unmanipulated T cell replete BM);   Drug: Tacrolimus;   Drug: Methotrexate;   Biological: Allogeneic Hematopoietic Stem Cell Transplantation (naive T cell-depleted PBSC)
  Sponsors:   Fred Hutchinson Cancer Research Center;   National Cancer Institute (NCI)
  Recruiting
• Phase 3 Pivotal Trial of NanoFlu™ in Older Adults

  NCT04120194

  Condition:   Influenza, Human
  Interventions:   Biological: NanoFlu;   Biological: Fluzone Quadrivalent
  Sponsor:   Novavax
  Recruiting
• A Randomized Trial of Pessary in Singleton Pregnancies With a Short Cervix

  NCT02901626

  Conditions:   Short Cervix;   Preterm Delivery
  Intervention:   Device: Pessary
  Sponsors:   The George Washington University Biostatistics Center;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
  Recruiting
• Respiratory Syncytial Virus (RSV) Investigational Vaccine in Infants Aged 6 and 7 Months Likely to be Unexposed to RSV

  NCT03636906

  Condition:   Respiratory Syncytial Virus Infections
  Interventions:   Biological: Respiratory syncytial virus (RSV) vaccine GSK3389245A;   Biological: Bexsero;   Biological: Nimenrix;   Biological: Menveo;   Biological: Synflorix;   Drug: Placebo
  Sponsor:   GlaxoSmithKline
  Recruiting
• A Study of an Ad26.RSV.preF-based Regimen in the Prevention of Reverse Transcriptase Polymerase Chain Reaction (RT-PCR)-Confirmed Respiratory Syncytial Virus (RSV)-Mediated Lower Respiratory Tract Disease in Adults Aged 65 Years and Older

  NCT03982199

  Conditions:   Respiratory Syncytial Viruses;   Respiratory Tract Diseases
  Interventions:   Biological: RSV Vaccine;   Biological: Placebo
  Sponsor:   Janssen Vaccines & Prevention B.V.
  Recruiting
• NeuMoDx PrEDiCTiNG Study Evaluation Plan

  NCT03970850

  Conditions:   Chlamydia Trachomatis Infection;   Neisseria Gonorrheae Infection
  Interventions:   Diagnostic Test: NeuMoDx CT/NG Assay;   Diagnostic Test: FDA-cleared NAATs
  Sponsors:   NeuMoDx Molecular, Inc.;   NAMSA
  Recruiting
• Study of a Levonorgestrel 52 mg Intrauterine System for the Treatment of Heavy Menstrual Bleeding

  NCT03642210

  Condition:   Menorrhagia
  Intervention:   Combination Product: Levonorgestrel 52 mg intrauterine system
  Sponsor:   Medicines360
  Recruiting
• A Study to Evaluate Scales for Repetitive and Restricted Behaviors in Children, Adolescents, and Adults With Autism Spectrum Disorder (ASD)

  NCT03611075

  Condition:   Autism Spectrum Disorder
  Intervention:   Other: No Intervention
  Sponsor:   Hoffmann-La Roche
  Recruiting
• Study of the Safety and Effectiveness of Motiva Implants®

  NCT03579901

  Condition:   Breast Implants
  Intervention:   Device: Silicone gel-filled breast implants - Motiva Implants® Investigational breast implants
  Sponsors:   Motiva USA LLC;   ICON plc;   Experien Group;   Biostatistical Consulting, Inc.
  Recruiting
• Study Comparing Emergency Contraception Effectiveness in Women Who Weight ≥ 80 kg

  NCT03537768

  Condition:   Contraception
  Interventions:   Drug: Ulipristal Acetate;   Drug: Levonorgestrel
  Sponsors:   Health Decisions;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
  Recruiting
• Evaluation of Patient Outcomes From the Kidney Allograft Outcomes AlloSure Registry

  NCT03326076

  Condition:   Kidney Transplant Rejection
  Interventions:   Diagnostic Test: Donor-derived cell-free DNA (AlloSure®);   Other: Standard care;   Diagnostic Test: Peripheral blood gene expression profiling (AlloMap Kidney);   Diagnostic Test: Analytic platform (IBox)
  Sponsor:   CareDx
  Recruiting
• Transfusion Trigger After Operations in High Cardiac Risk Patients

  NCT03229941

  Conditions:   Myocardial Infarction;   Coronary Revascularization;   Acute Renal Failure
  Intervention:   Procedure: Blood Transfusion
  Sponsor:   VA Office of Research and Development
  Recruiting
• A Trial to Describe the Immunogenicity and Safety of 2 Doses of Bivalent rLP2086 (Trumenba) and a Pentavalent Meningococcal Vaccine in Healthy Subjects >=10 to <26 Years of Age.

  NCT03135834

  Condition:   Meningococcal Vaccine
  Interventions:   Biological: MenABCWY;   Biological: Saline;   Biological: rLP2086;   Biological: MenACWY-CRM
  Sponsor:   Pfizer
  Recruiting
• Study to Assess Outcomes in Women Undergoing Either Hysteroscopic Sterilization (Essure®) or Laparoscopic Tubal Sterilization

  NCT03127722

  Condition:   Contraception
  Interventions:   Procedure: Blood draw;   Device: ESSURE (BAY1454032);   Procedure: Laparoscopic tubal sterilization
  Sponsor:   Bayer
  Recruiting
• Stimulation Of the Left Ventricular Endocardium for Cardiac Resynchronization Therapy in Non-Responders and Previously Untreatable Patients (SOLVE CRT)

  NCT02922036

  Condition:   Heart Failure
  Intervention:   Device: WiSE System
  Sponsor:   EBR Systems, Inc.
  Recruiting
• Pediatric ACL: Understanding Treatment Options

  NCT02772770

  Condition:   Anterior Cruciate Ligament Reconstruction
  Interventions:   Other: Non-operative treatment group will undergo standardized treatment which will include rehabilitation, bracing and certain activity restrictions;   Procedure: Surgical technique: Transphyseal reconstruction;   Procedure: Surgical technique: Partial transphyseal reconstruction;   Procedure: Surgical technique: Physeal sparing reconstruction by the Anderson method;   Procedure: Surgical technique: Physeal sparing reconstruction by the Micheli/Kocher method
  Sponsors:   Boston Children’s Hospital;   Children's Hospital of Philadelphia;   Children's Hospital Medical Center, Cincinnati;   Rady Children's Hospital, San Diego;   Washington University School of Medicine;   Children's Healthcare of Atlanta;   The Cleveland Clinic;   Tennessee Orthopedic Alliance;   Hospital for Special Surgery, New York;   Stanford University
  Recruiting
• Strategy to Prevent the Onset of Clinically-Apparent Rheumatoid Arthritis

  NCT02603146

  Conditions:   Healthy Participants;   Rheumatoid Arthritis (RA) Prevention
  Interventions:   Drug: Hydroxychloroquine;   Drug: HCQ Placebo
  Sponsors:   National Institute of Allergy and Infectious Diseases (NIAID);   Autoimmunity Centers of Excellence
  Recruiting
• Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL)

  NCT02365922

  Conditions:   FTLD;   Progressive Supranuclear Palsy (PSP);   Frontotemporal Dementia (FTD);   Corticobasal Degeneration (CBD);   PPA Syndrome;   Behavioral Variant Frontotemporal Dementia (bvFTD);   Semantic Variant Primary Progressive Aphasia (svPPA);   Nonfluent Variant Primary Progressive Aphasia (nfvPPA);   FTD With Amyotrophic Lateral Sclerosis (FTD/ALS);   Amyotrophic Lateral Sclerosis (ALS);   Oligosymptomatic PSP (oPSP);   Corticobasal Syndrome (CBS)
  Intervention:  
  Sponsors:   University of California, San Francisco;   National Center for Advancing Translational Science (NCATS);   National Institute of Neurological Disorders and Stroke (NINDS);   The Bluefield Project;   Tau Consortium
  Recruiting
• Phenotype, Genotype & Biomarkers in ALS and Related Disorders

  NCT02327845

  Conditions:   Amyotrophic Lateral Sclerosis;   Frontotemporal Dementia;   Primary Lateral Sclerosis;   Hereditary Spastic Paraplegia;   Progressive Muscular Atrophy;   Multisystem Proteinopathy
  Intervention:  
  Sponsors:   University of Miami;   National Institute of Neurological Disorders and Stroke (NINDS);   National Center for Advancing Translational Science (NCATS);   St. Jude Children's Research Hospital;   ALS Association
  Recruiting
• Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort

  NCT01574053

  Condition:   Huntington's Disease
  Intervention:  
  Sponsor:   CHDI Foundation, Inc.
  Recruiting
• Filgrastim-Mobilized Stem Cells for Transplantation Using Unrelated Donors

  NCT00785525

  Condition:   Healthy
  Intervention:   Drug: Filgrastim
  Sponsors:   Center for International Blood and Marrow Transplant Research;   National Marrow Donor Program
  Recruiting