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• Cognitive Biomarkers in Pediatric Brain Tumor Patients

  NCT02914067

  Condition:   Childhood Brain Tumor
  Interventions:   Other: Neurocognitive testing;   Device: rsfcMRI
  Sponsors:   Washington University School of Medicine;   Children's Discovery Institute
  Recruiting
• FET-PET/MRI for Surgical Assessment of Pediatric Brain Tumors

  NCT03451123

  Condition:   Pediatric Brain Tumors
  Intervention:   Drug: FET PET/MRI
  Sponsor:   University of Alabama at Birmingham
  Recruiting
• Therapeutic Targeting of Sex Differences in Pediatric Brain Tumor Glycolysis

  NCT03591861

  Condition:   Pediatric Brain Tumor
  Interventions:   Procedure: Ketogenic diet;   Drug: BCNU
  Sponsor:   Washington University School of Medicine
  Recruiting
• Ferumoxytol in Magnetic Resonance Imaging of Pediatric Patients With Brain Tumors

  NCT03234309

  Condition:   Childhood Brain Neoplasm
  Interventions:   Drug: Ferumoxytol;   Procedure: Magnetic Resonance Imaging
  Sponsors:   OHSU Knight Cancer Institute;   National Cancer Institute (NCI)
  Recruiting
• In Vivo Characterization of Macrophages in Pediatric Patients With Malignant Brain Tumors Using Ferumoxytol-enhanced MRI

  NCT03179449

  Condition:   Childhood Brain Neoplasm
  Interventions:   Diagnostic Test: Diagnostic (ferumoxytol-enhanced MRI);   Procedure: Surgery;   Drug: Ferumoxytol;   Other: Tissue Analysis
  Sponsors:   Michael Iv;   National Cancer Institute (NCI)
  Recruiting
• Understanding the Late Effects of Surviving a Pediatric Brain Tumor

  NCT03208387

  Conditions:   Brain Tumor;   Pediatric Brain Tumor;   Pediatric Cancer
  Interventions:   Diagnostic Test: Diffusion tensor imaging (DTI);   Diagnostic Test: Resting state functional connectivity MRI (rs-fcMRI);   Behavioral: Wechsler Intelligence Scale for Children - 5th edition (WISC-V);   Behavioral: California Verbal Learning Test (CVLT-C);   Behavioral: Beery Test of Visual Motor Integration 6th edition;   Behavioral: Grooved Pegboard;   Behavioral: PedsQL Multidimensional Fatigue Scale;   Diagnostic Test: MRI
  Sponsor:   Memorial Sloan Kettering Cancer Center
  Recruiting
• International HIT-MED Registry (I-HIT-MED)

  NCT02417324

  Condition:   Childhood Brain Tumor
  Intervention:  
  Sponsor:   Universitätsklinikum Hamburg-Eppendorf
  Recruiting
• Neoepitope-based Personalized Vaccine Approach in Pediatric Patients With Recurrent Brain Tumors

  NCT03068832

  Condition:   Pediatric Brain Tumor
  Interventions:   Biological: Personalized peptide vaccine;   Drug: Poly ICLC;   Procedure: Peripheral blood draw
  Sponsor:   Washington University School of Medicine
  Not yet recruiting
• Components of Social Functioning in Survivors of Pediatric Brain Tumors

  NCT03361033

  Conditions:   Brain Tumor, Pediatric;   Medulloblastoma, Pediatric
  Intervention:  
  Sponsors:   St. Jude Children's Research Hospital;   American Cancer Society, Inc.
  Recruiting
• Phase I Study of Mebendazole Therapy for Recurrent/Progressive Pediatric Brain Tumors

  NCT02644291

  Conditions:   Medulloblastoma;   Astrocytoma, Grade III;   Glioblastoma;   Anaplastic Astrocytoma;   Brain Stem Neoplasms, Malignant;   Oligodendroblastoma;   Anaplastic Oligodendroglioma;   Malignant Glioma
  Intervention:   Drug: Mebendazole
  Sponsor:   Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
  Recruiting
• Using MRI-Guided Laser Heat Ablation to Induce Disruption of the Peritumoral Blood Brain Barrier to Enhance Delivery and Efficacy of Treatment of Pediatric Brain Tumors

  NCT02372409

  Conditions:   Glioma;   Pilocytic Astrocytoma;   Anaplastic Astrocytoma;   Glioblastoma;   Mixed Oligoastrocytoma;   Mixed Glioma;   Oligodendroglioma;   Optic Glioma;   Astrocytoma
  Interventions:   Device: MRI-guided laser ablation;   Drug: Doxorubicin;   Drug: Etoposide;   Device: Dynamic contrast-enhanced (DCE) MRI;   Device: Dynamic susceptibility contrast (DSC) MRI
  Sponsor:   Washington University School of Medicine
  Recruiting
• Testing the Safety and Tolerability of CX-4945 in Patients With Recurrent Medulloblastoma Who May or May Not Have Surgery

  NCT03904862

  Condition:   Medulloblastoma, Childhood
  Intervention:   Drug: CX 4945
  Sponsors:   Pediatric Brain Tumor Consortium;   St. Jude Children's Research Hospital;   National Cancer Institute (NCI)
  Recruiting
• Computer Training Program for Younger Patients With a Brain Tumor Who Underwent Radiation Therapy

  NCT01503086

  Conditions:   Brain Neoplasm;   Recurrent Brain Neoplasm
  Interventions:   Procedure: Cognitive Assessment;   Other: Computer-Assisted Cognitive Training;   Procedure: Psychosocial Assessment and Care;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration
  Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• Creating a Decision Support System for the Corporate Management of Physical Therapy

  NCT03586401

  Conditions:   Childhood Acute Lymphoblastic Leukemia in Remission;   Childhood Brain Tumor;   Physical Activity;   Physical Disability
  Intervention:  
  Sponsor:   Federal Research Institute of Pediatric Hematology, Oncology and Immunology
  Recruiting
• Re-Irradiation of Progressive or Recurrent DIPG

  NCT03126266

  Condition:   Recurrent or Progressive Diffuse Intrinsic Pontine Glioma
  Intervention:   Radiation: re-irradiation
  Sponsors:   University of Calgary;   Janeway Children's Health and Rehabilitation Centre;   IWK Health Centre;   St. Justine's Hospital;   Montreal Children's Hospital of the MUHC;   CHU de Quebec-Universite Laval;   Children's Hospital of Eastern Ontario;   The Hospital for Sick Children;   McMaster Children's Hospital;   London Health Sciences Centre;   CancerCare Manitoba;   Stollery Children's Hospital;   Alberta Children's Hospital;   British Columbia Children's Hospital
  Recruiting
• PRecISion Medicine for Children With Cancer

  NCT03336931

  Conditions:   Childhood Cancer;   Childhood Solid Tumor;   Childhood Brain Tumor;   Childhood Leukemia;   Refractory Cancer;   Relapsed Cancer
  Intervention:   Diagnostic Test: Molecular profiling and drug testing
  Sponsors:   Sydney Children's Hospitals Network;   Children's Cancer Institute Australia;   Australian and New Zealand Children's Haematology/Oncology Group;   Garvan Institute of Medical Research;   German Cancer Research Center
  Recruiting
• HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors

  NCT03911388

  Conditions:   Neoplasms, Brain;   Glioblastoma Multiforme;   Glioblastoma of Cerebellum;   Neoplasms;   Astrocytoma;   Astrocytoma, Cerebellar;   Neuroectodermal Tumors;   Neuroectodermal Tumors, Primitive;   Cerebellar PNET, Childhood;   Cerebellar Neoplasms;   Cerebellar Neoplasms, Primary;   Cerebellar Neoplasm, Malignant;   Cerebellar Neoplasm Malignant Primary;   Neoplasm Metastases;   Neoplasm Malignant;   Neoplasms, Neuroepithelial;   Neoplasms, Germ Cell and Embryonal;   Neoplasms by Histologic Type;   Neoplasms, Glandular and Epithelial;   Neoplasms, Nerve Tissue;   Central Nervous System Neoplasms, Primary;   Central Nervous System Neoplasms, Malignant;   Nervous System Neoplasms;   Neoplasms by Site;   Brain Diseases;   Central Nervous System Diseases;   Nervous System Diseases;   Medulloblastoma Recurrent;   HSV;   Virus;   Pediatric Brain Tumor;   Nervous System Cancer;   Primitive Neuroectodermal Tumor (PNET) of Cerebellum
  Intervention:   Biological: G207
  Sponsor:   University of Alabama at Birmingham
  Recruiting
• Dose Escalation Study of CLR 131 in Children and Adolescents With Relapsed or Refractory Malignant Tumors Including But Not Limited to Neuroblastoma, Rhabdomyosarcoma, Ewings Sarcoma, and Osteosarcoma

  NCT03478462

  Conditions:   Pediatric Solid Tumor;   Pediatric Lymphoma;   Pediatric Brain Tumor;   DIPG;   Neuroblastoma;   Ewing Sarcoma;   Rhabdomyosarcoma;   Osteosarcoma
  Intervention:   Drug: CLR 131
  Sponsor:   Cellectar Biosciences, Inc.
  Recruiting
• Clinical Benefit of Using Molecular Profiling to Determine an Individualized Treatment Plan for Patients With High Grade Glioma

  NCT03739372

  Conditions:   Glioma;   Glioma of Brain;   Cancer;   Pediatric Cancer;   Pediatric Brain Tumor;   Astrocytoma;   Glioblastoma;   Hemispheric
  Intervention:   Other: Specialized tumor board recommendation
  Sponsors:   University of California, San Francisco;   Pacific Pediatric Neuro-Oncology Consortium
  Recruiting
• SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors

  NCT03434262

  Conditions:   Anaplastic Astrocytoma;   Anaplastic Ependymoma;   Anaplastic Ganglioglioma;   Anaplastic Meningioma;   Anaplastic Oligodendroglioma;   Pleomorphic Xanthoastrocytoma, Anaplastic;   Atypical Teratoid/Rhabdoid Tumor;   Brain Cancer;   Brain Tumor;   Central Nervous System Neoplasms;   Choroid Plexus Carcinoma;   CNS Embryonal Tumor With Rhabdoid Features;   Ganglioneuroblastoma of Central Nervous System;   CNS Tumor;   Embryonal Tumor of CNS;   Ependymoma;   Glioblastoma;   Glioma;   Glioma, Malignant;   Medulloblastoma;   Medulloblastoma; Unspecified Site;   Medulloepithelioma;   Neuroepithelial Tumor;   Neoplasms;   Neoplasms, Neuroepithelial;   Papillary Tumor of the Pineal Region (High-grade Only);   Pediatric Brain Tumor;   Pineal Parenchymal Tumor of Intermediate Differentiation (High-grade Only);   Pineoblastoma;   Primitive Neuroectodermal Tumor;   Recurrent Medulloblastoma;   Refractory Brain Tumor;   Neuroblastoma. CNS;   Glioblastoma, IDH-mutant;   Glioblastoma, IDH-wildtype;   Medulloblastoma, Group 3;   Medulloblastoma, Group 4;   Glioma, High Grade;   Neuroepithelial Tumor, High Grade;   Medulloblastoma, SHH-activated and TP53 Mutant;   Medulloblastoma, SHH-activated and TP53 Wildtype;   Medulloblastoma, Chromosome 9q Loss;   Medulloblastoma, Non-WNT Non-SHH, NOS;   Medulloblastoma, Non-WNT/Non-SHH;   Medulloblastoma, PTCH1 Mutation;   Medulloblastoma, WNT-activated;   Ependymoma, Recurrent;   Glioma, Recurrent High Grade;   Glioma, Recurrent Malignant;   Embryonal Tumor, NOS;   Glioma, Diffuse Midline, H3K27M-mutant;   Embryonal Tumor With Multilayered Rosettes (ETMR);   Ependymoma, NOS, WHO Grade III;   Ependymoma, NOS, WHO Grade II;   Medulloblastoma, G3/G4;   Ependymoma, RELA Fusion Positive
  Interventions:   Drug: Gemcitabine;   Drug: ribociclib;   Drug: sonidegib;   Drug: trametinib;   Biological: filgrastim
  Sponsors:   St. Jude Children's Research Hospital;   Novartis Pharmaceuticals
  Recruiting
• Ex Vivo Drug Sensitivity Testing and Mutation Profiling

  NCT03860376

  Conditions:   Recurrent Childhood Acute Myeloid Leukemia;   Recurrent Childhood Acute Lymphoblastic Leukemia;   Recurrent Childhood Large Cell Lymphoma;   Refractory Childhood Acute Lymphoblastic Leukemia;   Refractory Childhood Hodgkin Lymphoma;   Refractory Childhood Malignant Germ Cell Neoplasm;   Recurrent Childhood Brain Tumor;   Recurrent Childhood Brainstem Glioma;   Recurrent Childhood Rhabdomyosarcoma;   Recurrent Childhood Soft Tissue Sarcoma;   Recurrent Childhood Ependymoma;   Recurrent Childhood Lymphoblastic Lymphoma;   Recurrent Childhood Gliosarcoma;   Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive
  Intervention:  
  Sponsors:   Florida International University;   Nicklaus Children's Hospital f/k/a Miami Children's Hospital
  Recruiting
• Methionine PET/CT Studies In Patients With Cancer

  NCT00840047

  Conditions:   Brain Tumors and/or Solid Tumors Including;   Brain Stem Glioma;   High Grade CNS Tumors;   Ependymoma;   Medulloblastoma;   Craniopharyngioma;   Low Grade CNS Tumors;   Hodgkin Lymphoma;   Non Hodgkin Lymphoma;   Ewing Sarcoma;   Osteosarcoma;   Rhabdomyosarcoma;   Neuroblastoma;   Other
  Intervention:   Drug: Methionine
  Sponsor:   St. Jude Children's Research Hospital
  Recruiting
• Neurobehavioral Outcomes and Quality of Life in Pediatric Patients With Brain or Head/Neck Tumors Receiving Proton or Photon Radiotherapy

  NCT02608762

  Condition:   Brain Tumor
  Intervention:   Radiation: standard adjuvant local radiation therapy or cranial radiation therapy
  Sponsor:   Chang Gung Memorial Hospital
  Recruiting
• Strict Classic Ketogenic Diet as a Therapy for Recurrent or Progressive and Refractory Brain Tumors in Children

  NCT03955068

  Conditions:   Recurrent Brain Tumor, Childhood;   Ketogenic Diet
  Intervention:   Other: Strict Classic Ketogenic Diet
  Sponsor:   Daniel Bowers
  Not yet recruiting
• Social Emotional Development in Young Children With Cancer

  NCT03086421

  Conditions:   Solid Tumor, Childhood;   Brain Tumor, Pediatric
  Intervention:   Behavioral: Questionnaires
  Sponsors:   St. Jude Children's Research Hospital;   American Cancer Society, Inc.
  Recruiting
• Multicenter Registry for Patients With Childhood.Onset Craniopharyngioma, Xanthogranuloma, Cysts of Rathke's Pouch, Meningioma, Pituitary Adenoma, Arachnoid Cysts

  NCT04158284

  Conditions:   Craniopharyngioma;   Obesity
  Intervention:  
  Sponsors:   Klinikum Oldenburg gGmbH;   Gesellschaft für Pädiatrische Onkologie und Hämatologie (GPOH);   Deutsche Gesellschaft für Kinderendokrinologie und Diabetologie (DGKED);   Deutsche Gesellschaft für Endokrinologie (DGE);   Arbeitsgemeinschaft Pädiatrische Radioonkologie (APRO);   Deutschen Gesellschaft für Radioonkologie (DEGRO)
  Recruiting
• The Diagnostic Value of 18F-FET PET/MRI for CNS Tumors in Children and Adolescents

  NCT03402425

  Conditions:   Positron-Emission Tomography;   Brain Neoplasms, Childhood
  Intervention:   Diagnostic Test: 18F-FET PET
  Sponsors:   Rigshospitalet, Denmark;   Børnecancerfonden
  Recruiting
• A Longitudinal Assessment of Frailty in Young Adult Survivors of Childhood Cancer

  NCT02256137

  Conditions:   Acute Lymphoblastic Leukemia;   Brain Tumor;   Hodgkin Lymphoma
  Intervention:  
  Sponsors:   St. Jude Children's Research Hospital;   National Cancer Institute (NCI)
  Recruiting
• International Society of Paediatric Oncology (SIOP) PNET 5 Medulloblastoma

  NCT02066220

  Condition:   Brain Tumors
  Interventions:   Radiation: Radiotherapy without Carboplatin;   Drug: Reduced-intensity maintenance chemotherapy;   Radiation: Radiotherapy with Carboplatin;   Drug: Maintenance chemotherapy
  Sponsors:   Universitätsklinikum Hamburg-Eppendorf;   Deutsche Kinderkrebsstiftung
  Recruiting
• Study of GDC-0084 in Pediatric Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma or Diffuse Midline Gliomas

  NCT03696355

  Condition:   Brain and Central Nervous System Tumors
  Interventions:   Drug: GDC-0084;   Radiation: radiation therapy
  Sponsors:   St. Jude Children's Research Hospital;   Kazia Therapeutics Limited
  Recruiting
• A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma

  NCT01878617

  Condition:   Medulloblastoma
  Interventions:   Radiation: Craniospinal Irradiation with boost to the primary tumor site;   Drug: Cyclophosphamide;   Drug: Cisplatin;   Drug: Vincristine;   Drug: Vismodegib;   Drug: Pemetrexed;   Drug: Gemcitabine;   Other: Aerobic Training;   Other: Neurocognitive Remediation
  Sponsors:   St. Jude Children's Research Hospital;   Genentech, Inc.;   National Cancer Institute (NCI)
  Recruiting
• Children and Adolescents With Leukemia, Brain Tumors, and Sarcomas

  NCT04101123

  Conditions:   Leukemia;   Brain Tumor;   Sarcoma;   Childhood Cancer;   Cancer;   Adolescent Cancer
  Intervention:   Other: Non-Interventional
  Sponsor:   Martin-Luther-Universität Halle-Wittenberg
  Not yet recruiting
• Study of the Bromodomain (BRD) and Extra-Terminal Domain (BET) Inhibitor BMS-986158 in Pediatric Cancer

  NCT03936465

  Conditions:   Solid Tumor, Childhood;   Lymphoma;   Brain Tumor, Pediatric
  Intervention:   Drug: BMS-986158
  Sponsors:   Dana-Farber Cancer Institute;   Stand Up To Cancer
  Recruiting
• Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, Hypermutated Brain Tumors, Ependymoma or Medulloblastoma

  NCT02359565

  Conditions:   Constitutional Mismatch Repair Deficiency Syndrome;   Lynch Syndrome;   Malignant Glioma;   Recurrent Brain Neoplasm;   Recurrent Childhood Ependymoma;   Recurrent Diffuse Intrinsic Pontine Glioma;   Recurrent Medulloblastoma;   Refractory Brain Neoplasm;   Refractory Diffuse Intrinsic Pontine Glioma;   Refractory Ependymoma;   Refractory Medulloblastoma
  Interventions:   Procedure: Diffusion Tensor Imaging;   Procedure: Diffusion Weighted Imaging;   Procedure: Dynamic Contrast-Enhanced Magnetic Resonance Imaging;   Procedure: Dynamic Susceptibility Contrast-Enhanced Magnetic Resonance Imaging;   Other: Laboratory Biomarker Analysis;   Procedure: Magnetic Resonance Spectroscopic Imaging;   Biological: Pembrolizumab;   Procedure: Perfusion Magnetic Resonance Imaging
  Sponsor:   National Cancer Institute (NCI)
  Recruiting