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• Ocrelizumab for Psychosis by Autoimmunity

  NCT03971487

  Conditions:   Schizo-Affective Type of Psychosis;   Schizophrenia
  Interventions:   Behavioral: Psychosis and cognitive assessments;   Behavioral: Physical and neuro-cognitive evaluations;   Diagnostic Test: Safety labs and electrocardiogram;   Biological: Ocrelizumab infusion
  Sponsors:   The Methodist Hospital System;   Genentech, Inc.
  Not yet recruiting
• Repetitive Transcranial Magnetic Stimulation (rTMS) Self-Referential Processing (rTMS-SRP)

  NCT04068857

  Conditions:   Schizophrenia;   Schizo Affective Disorder
  Intervention:   Device: rTMS
  Sponsor:   Indiana University
  Recruiting
• A Controlled Study With Remote Web-based Adapted Physical Activity (e-APA) in Psychotic Disorders

  NCT03261817

  Conditions:   Schizophrenia;   Physical Activity;   Schizo Affective Disorder
  Interventions:   Behavioral: Physical activity (APA);   Behavioral: Health Education program (HE)
  Sponsors:   University Hospital, Caen;   Centre Hospitalier du Rouvray
  Recruiting
• Correlational Explorations Between Clinical Recovery and Personal Recovery

  NCT04125030

  Conditions:   Psychotic Disorders;   Mood Disorders
  Intervention:   Other: Validation of questionnaires
  Sponsors:   Jean-Francois Pelletier;   Yale University
  Recruiting
• Levetiracetam in Early Psychosis

  NCT03129360

  Conditions:   Psychosis;   Schizophrenia;   Schizo Affective Disorder;   Schizophreniform
  Intervention:   Drug: Levetiracetam
  Sponsors:   NYU Langone Health;   National Institutes of Health (NIH)
  Recruiting
• Effects of Intranasal Insulin on Neuroimaging Markers and Cognition in Patients With Psychotic Disorders

  NCT03943537

  Conditions:   Psychosis;   Schizophrenia;   Schizo Affective Disorder;   Bipolar I Disorder
  Intervention:   Drug: Intranasal Insulin
  Sponsor:   Mclean Hospital
  Not yet recruiting
• CBT-I as Early Intervention of Mood Disorders

  NCT03000894

  Condition:   Insomnia Due to Mental Disorder
  Intervention:   Behavioral: Cognitive Behavioral Therapy for Insomnia (CBT-I)
  Sponsors:   The University of Hong Kong;   Kowloon Hospital, Hong Kong
  Not yet recruiting
• L-arginine Study for Persistent Symptoms of Schizophrenia

  NCT04054973

  Conditions:   Schizo Affective Disorder;   Schizophrenia
  Interventions:   Drug: L-arginine;   Drug: Sapropterin Dihydrochloride
  Sponsor:   University of Massachusetts, Worcester
  Recruiting
• Financial Incentives to Improve Acceptance of Antipsychotic Injections

  NCT03192631

  Conditions:   Schizophrenia;   Schizo Affective Disorder;   Bipolar I Disorder
  Intervention:   Other: Financial incentive
  Sponsor:   Focus Community Mental Health Team
  Not yet recruiting
• Cromoglycate Adjunctive Therapy for Outpatients With Schizophrenia

  NCT03794076

  Conditions:   Schizophrenia;   Schizo Affective Disorder
  Interventions:   Drug: Cromoglycate;   Drug: Placebo
  Sponsors:   Vishwajit Nimgaonkar, MD PhD;   Stanley Medical Research Institute
  Recruiting
• D-serine Augmentation of Neuroplasticity

  NCT03711500

  Conditions:   Schizophrenia;   Schizo Affective Disorder
  Interventions:   Drug: D-serine;   Drug: Placebo
  Sponsors:   New York State Psychiatric Institute;   Nathan Kline Institute for Psychiatric Research
  Recruiting
• Cognitive Effects of Nimodipine in Patients With Schizophrenia

  NCT03671525

  Conditions:   Schizophrenia;   Schizo Affective Disorder
  Interventions:   Drug: Nimodipine;   Drug: Placebo oral capsule
  Sponsor:   Johns Hopkins University
  Recruiting
• Virtual Reality Avatar Therapy for People Hearing Voices

  NCT04099940

  Conditions:   Psychosis;   Schizophrenia;   Schizo Affective Disorder;   Hearing Voices When No One is Talking (Symptom)
  Interventions:   Behavioral: Virtual Reality Avatar Therapy (VRAT);   Behavioral: Assertiveness Training Program (ATP)
  Sponsor:   Psychiatric University Hospital, Zurich
  Not yet recruiting
• Reproductive Life Planning for Women With Mental Illness

  NCT03969589

  Conditions:   Psychotic Disorders;   Mood Disorders;   Stress Disorders, Post-Traumatic
  Interventions:   Behavioral: Reproductive Life Planning-Mental Health (RLP-MH) Intervention;   Other: Written Materials on Reproductive Life Planning
  Sponsor:   VA Office of Research and Development
  Recruiting
• Virtual Reality Training for Social Skills in Schizophrenia - Comparison With Cognitive Training

  NCT04005794

  Conditions:   Schizophrenia;   Schizo Affective Disorder;   Social Skills
  Interventions:   Behavioral: VR social skills training;   Behavioral: Cognitive training
  Sponsor:   Vanderbilt University
  Not yet recruiting
• Telmisartan Pilot Study on Treatment Resistant Schizophrenia

  NCT03868839

  Conditions:   Schizophrenia;   Schizo Affective Disorder;   Treatment-resistant Schizophrenia
  Intervention:   Drug: Telmisartan Pill
  Sponsor:   Xiaoduo Fan
  Recruiting
• Confirmatory Efficacy Trial of a Gluten-Free Diet in a Subgroup of Persons With Schizophrenia Who Have High Levels of IgG Anti-Gliadin Antibodies (AGA IG)

  NCT03183609

  Conditions:   Schizophrenia;   Gluten Sensitivity;   Schizo Affective Disorder
  Interventions:   Other: Gluten Flour in Protein Shake;   Other: Rice Flour in Protein Shake
  Sponsor:   University of Maryland, Baltimore
  Recruiting
• Multi-modal Assessment of Gamma-aminobutyric Acid (GABA) Function in Psychosis

  NCT04004416

  Conditions:   Schizophrenia;   Bipolar Disorder;   Healthy;   Psychosis;   Schizophreniform Disorders;   Schizo Affective Disorder
  Interventions:   Other: Placebo and fMRI;   Drug: Lorazepam and fMRI
  Sponsors:   University of Michigan;   National Institute of Mental Health (NIMH)
  Not yet recruiting
• Early Psychosis Intervention - Spreading Evidence-based Treatment

  NCT03919760

  Conditions:   First Episode Psychosis;   Schizophrenia, Childhood;   Psychosis;   Schizophrenia;   Schizoaffective Disorder;   Schizophreniform Disorders;   Bipolar I Disorder;   Schizophrenia Spectrum and Other Psychotic Disorders;   Affective Disorders, Psychotic;   Psychotic Disorder Due to Unspecified Substance
  Intervention:   Behavioral: NAVIGATE
  Sponsors:   Centre for Addiction and Mental Health;   Canadian Institutes of Health Research (CIHR);   Institute for Clinical Evaluative Sciences;   North Bay Regional Health Centre;   Health Sciences North;   Niagara Region Public Health;   Lakeridge Health Corporation
  Not yet recruiting
• Assessment and Treatment for Chronic Pain in Veterans With Serious Mental Illness

  NCT04118283

  Conditions:   Chronic Pain;   Schizophrenia;   Psychotic Disorders;   Bipolar Disorder;   Affective Disorders, Psychotic
  Interventions:   Behavioral: Cognitive Behavioral Therapy for Chronic Pain;   Behavioral: Health and Wellness
  Sponsors:   VA Office of Research and Development;   VA Maryland Health Care System
  Not yet recruiting
• Mental Health in Refugees and Asylum Seekers

  NCT03109028

  Condition:   Affective Disorders
  Interventions:   Behavioral: Peer-to-Peer-Groupintervention;   Behavioral: Smartphone-based-Intervention;   Behavioral: Gendersensitive-Groupintervention;   Behavioral: Empowerment-Groupintervention;   Behavioral: Adolescent-Groupintervention;   Other: Treatment as Ususal
  Sponsors:   Charite University, Berlin, Germany;   Zentralinstitut für Seelische Gesundheit Mannheim;   University of Potsdam;   University of Ulm;   Philipps University Marburg Medical Center;   RWTH Aachen University;   Ludwig-Maximilians - University of Munich
  Recruiting
• A Study of Pregnant and Postpartum Women With and Without Mood Disorders

  NCT03615794

  Conditions:   Bipolar Disorder;   Major Depressive Disorder;   Postpartum Depression;   Postpartum Psychosis
  Intervention:  
  Sponsor:   Johns Hopkins University
  Recruiting
• Bazedoxifene -Treatment for Women With Schizophrenia

  NCT04113993

  Conditions:   Schizophrenia;   Schizophreniform Disorders;   Schizo Affective Disorder
  Interventions:   Drug: Bazedoxifene Acetate;   Drug: Placebo
  Sponsors:   The Alfred;   Monash University;   Monash Health
  Not yet recruiting
• Compassion Meditation for Older Adults

  NCT03964246

  Condition:   Anxiety and Mood Disorders
  Interventions:   Behavioral: Compassion Meditation (CM) intervention;   Other: Heathy Aging Psychoeducation
  Sponsor:   VA Office of Research and Development
  Recruiting
• PrEP and Consumptions

  NCT03449771

  Conditions:   Psychoactive Substance Use;   Mood Disorders
  Intervention:   Other: self-administered questionnaire
  Sponsor:   University Hospital, Montpellier
  Recruiting
• Targeting Auditory Hallucinations With Alternating Current Stimulation

  NCT03221270

  Conditions:   Schizophrenia;   Schizo Affective Disorder
  Interventions:   Device: tACS (alpha);   Device: Sham tACS (alpha)
  Sponsors:   University of North Carolina, Chapel Hill;   National Institute of Mental Health (NIMH)
  Recruiting
• Brain Emotion Circuitry-Targeted Self-Monitoring and Regulation Therapy (BE-SMART)

  NCT03183388

  Condition:   Mood Disorders
  Intervention:   Behavioral: BE-SMART
  Sponsors:   Yale University;   National Institute of Mental Health (NIMH)
  Recruiting
• Memantine Effects on Sensorimotor Gating and Neurocognition in Schizophrenia

  NCT03860597

  Conditions:   Schizophrenia;   Schizo Affective Disorder;   Schizoaffective Disorder;   Healthy
  Interventions:   Drug: Memantine;   Drug: Placebos
  Sponsor:   University of California, San Diego
  Recruiting
• Effectiveness of Using the Progressive Goal Attainment Program in Anxiety and Mood Disorders

  NCT02819986

  Conditions:   Anxiety;   Mood Disorder
  Intervention:   Behavioral: Progressive Goal Attainment Program
  Sponsor:   St. Joseph's Healthcare Hamilton
  Recruiting
• Assessment of Cardiac Autonomic Behavior in Patients With Mood Disorders

  NCT01272518

  Conditions:   Mood Disorder;   Mania;   Depression
  Intervention:  
  Sponsor:   Sao Jose do Rio Preto Medical School
  Recruiting
• Hostile Interpretation Bias Training to Treat Irritability

  NCT03592368

  Conditions:   Irritable Mood;   Mood Disorders
  Intervention:   Device: IBT
  Sponsor:   University of Colorado, Denver
  Recruiting
• The Analysis of Physical, Physiological and Behavioral Data Collected From Sensors That Track the Mental Condition of Psychiatric Patients

  NCT03714893

  Condition:   Psychiatric Disorders Mood
  Intervention:   Device: Sensor wrist watch
  Sponsor:   Sheba Medical Center
  Not yet recruiting
• Biological Classification of Mental Disorders

  NCT03984084

  Conditions:   Mental Disorder;   Depressive Disorder;   Anxiety;   Trauma and Stressor Related Disorders
  Intervention:   Other: no intervention
  Sponsor:   Max-Planck-Institute of Psychiatry
  Recruiting
• Optimizing Long-Term Outcomes for Winter Depression With CBT-SAD and Light Therapy

  NCT03691792

  Condition:   Seasonal Affective Disorder
  Interventions:   Behavioral: Cognitive-Behavioral Therapy (CBT-SAD);   Other: Light Therapy
  Sponsors:   University of Vermont;   Teodor Postolache;   Kathryn Roecklein;   Peter Franzen;   Greg Siegle;   David Kolko;   Pamela Vacek
  Recruiting
• Study of Sensorimotor Compatibility Effects in Bipolar Affective Disorder.

  NCT03249857

  Condition:   Bipolar Affective Disorder
  Interventions:   Behavioral: cognitive tasks + IQ + MINI;   Behavioral: cognitive tasks
  Sponsor:   Centre Hospitalier Universitaire de Saint Etienne
  Recruiting
• Family Study of Affective and Anxiety Spectrum Disorders

  NCT00071786

  Conditions:   Mood Disorders;   Anxiety Disorders
  Intervention:  
  Sponsor:   National Institute of Mental Health (NIMH)
  Recruiting
• Telemetry-Triggered Educational Content Delivery Using MyChart in Mood Disorders

  NCT03575728

  Conditions:   Bipolar Disorder;   Mood Disorders
  Intervention:   Other: MyChart-MHT
  Sponsor:   Sunnybrook Health Sciences Centre
  Recruiting
• Evaluation of an App for Smartphones for People With a Bipolar Affective Disorder

  NCT03275714

  Condition:   Bipolar Affective Disorder
  Intervention:   Device: Smartphone APP
  Sponsor:   Medical University of Graz
  Recruiting
• Design and Methods of the Mood Disorder Cohort Research Consortium (MDCRC) Study

  NCT03088657

  Conditions:   Mood Disorders;   Bipolar Disorder;   Major Depressive Disorder
  Intervention:  
  Sponsors:   Korea University Anam Hospital;   Ministry of Health & Welfare, Korea;   Seoul National University Hospital;   Severance Hospital;   Seoul National University Bundang Hospital;   Samsung Medical Center;   Gyeongsang National University Hospital;   Pusan National University Hospital;   Chonnam National University Hospital;   National Center for Mental Health, Korea
  Recruiting
• Research of Unified Protocol for the Treatment of Common Mental Disorders in Adolescents in Hong Kong

  NCT04091139

  Conditions:   Depressive Disorder;   Anxiety Disorders
  Interventions:   Behavioral: Unified protocol for adolescents (UP-A);   Behavioral: Treatment as usual (TAU)
  Sponsors:   Chinese University of Hong Kong;   Castle Peak Hospital
  Recruiting
• A Clinical Trial Via Telepsychiatry of Treatments for the Management of Emotional Dysregulation in Youth

  NCT03911414

  Conditions:   Mood Disturbance;   Mood Disorders;   Natural Supplements;   Alternative Treatment
  Interventions:   Drug: Open-label Treatment with Omega-3 Fatty Acids + Inositol;   Drug: Open-label Treatment with N-acetylcysteine
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Outpatient Nurse Monitoring Under the Prevention of Recurrent Suicidal

  NCT02721316

  Conditions:   Mood Disorder;   Reactive Depression
  Intervention:   Other: Supported with intensive nursing follow post hospitalization
  Sponsor:   University Hospital, Montpellier
  Not yet recruiting
• A Pilot Study of Prophylactic Management of Lamotrigine in Pregnant Women

  NCT03774641

  Conditions:   Bipolar Disorder;   Major Depressive Disorder;   Schizo Affective Disorder
  Intervention:   Drug: Lamictal
  Sponsor:   Johns Hopkins University
  Recruiting
• Effect of Systemic Inflammation on Emotion and Cognition in Patients With Mood Disorder - A Vaccine Study

  NCT03523767

  Condition:   Major Depressive Disorder
  Interventions:   Biological: S.typhi Injection;   Biological: Normal Saline Injection
  Sponsor:   The University of Texas Health Science Center, Houston
  Recruiting
• Anti-stigma Intervention for Chinese American Older Adults

  NCT03820297

  Conditions:   Mood Disorders;   Anxiety Disorders
  Intervention:   Behavioral: 10 sessions of ASGI
  Sponsors:   NYU Langone Health;   Substance Abuse and Mental Health Services Administration (SAMHSA)
  Not yet recruiting
• Doing More With Less": Optimizing Psychotherapeutic Services in the Mental Health System

  NCT03608449

  Conditions:   Anxiety Disorder;   Affective Disorders;   Personality Disorders
  Intervention:   Other: questionnaires
  Sponsor:   Shalvata Mental Health Center
  Not yet recruiting
• Oxytocin on Irritability/Emotional Dysregulation of Disruptive Behavior and Mood Disorders

  NCT02824627

  Conditions:   Mood Disorder;   Disruptive Behavior Disorders
  Interventions:   Drug: Oxytocin;   Drug: Placebo
  Sponsor:   University of Nebraska
  Recruiting
• Multimodal Imaging of ECT Effects

  NCT02871141

  Condition:   Major Depressive Disorder
  Interventions:   Procedure: electroconvulsive therapy;   Drug: Antidepressant
  Sponsor:   Charite University, Berlin, Germany
  Recruiting
• Promoting Widowed Elders Lifestyle After Loss

  NCT02631291

  Conditions:   Mood Disorders;   Depression;   Anxiety;   Grief;   Bereavement;   Health Behavior
  Interventions:   Behavioral: Behavioral self-monitoring;   Behavioral: Behavioral self-monitoring + Motivational interviewing
  Sponsor:   University of Pittsburgh
  Recruiting
• Technology Enhanced Family Treatment

  NCT03913013

  Conditions:   Mood Disorders;   Bipolar Disorder;   Major Depression
  Intervention:   Behavioral: Family-Focused Treatment with MCC App
  Sponsors:   University of California, Los Angeles;   National Institute of Mental Health (NIMH)
  Recruiting
• Prevalence of Mood Disorders and Mental Health Service Use Among Immigrants in Santiago, Chile

  NCT04114565

  Condition:   Major Depressive Disorder
  Intervention:  
  Sponsors:   Pontificia Universidad Catolica de Chile;   Fondo Nacional de Desarrollo Científico y Tecnológico, Chile
  Recruiting
• Quantitative Investigation of Environment and Participation

  NCT04106960

  Conditions:   Supported Accommodation Residents;   Schizophrenia, Shizotypal and Delusional Disorders;   Mood Affective Disorders;   Disorders of Adult Personality and Behavior
  Intervention:   Other: No Intevention Used
  Sponsors:   Queen Margaret University;   NHS Lothian
  Not yet recruiting
• Racing and Crowded Thoughts in Mood Disorders

  NCT02036606

  Condition:   Bipolar Disorder
  Intervention:   Behavioral: questionary
  Sponsor:   University Hospital, Strasbourg, France
  Recruiting
• Pilot Study of Neuromodulation for Enhancement of Emotion Regulation in Bipolar Mood Disorders

  NCT03622749

  Conditions:   Bipolar Disorder;   Transcranial Magnetic Stimulation
  Intervention:   Device: Transcranial Magnetic Stimulation (TMS)
  Sponsors:   Massachusetts General Hospital;   National Institute of Neurological Disorders and Stroke (NINDS)
  Not yet recruiting
• Low Nicotine Content Cigarettes in Vulnerable Populations: Affective Disorders

  NCT04090879

  Condition:   Tobacco Use Disorder
  Interventions:   Other: Cigarettes with varying nicotine content;   Other: E-Cigarettes
  Sponsors:   Brown University;   Food and Drug Administration (FDA);   National Institute on Drug Abuse (NIDA);   University of Vermont
  Not yet recruiting
• The Psychobiology of Childhood Temperament

  NCT00060775

  Conditions:   Mood Disorders;   Anxiety Disorders;   Adolescents
  Intervention:  
  Sponsor:   National Institute of Mental Health (NIMH)
  Recruiting
• A Study on Better Cognitive Functioning Through Braintraining on the Internet

  NCT04006756

  Conditions:   Depression;   Late Life Mood Disorder;   Impaired Cognition;   Alteration in Mood;   Alteration in Cognition
  Interventions:   Behavioral: Online cognitive training 1;   Behavioral: Online cognitive training 2
  Sponsor:   VU University Medical Center
  Not yet recruiting
• Imaging SV2A in Mood Disorders

  NCT02734602

  Conditions:   Major Depressive Disorder;   Post-Traumatic Stress Disorder
  Interventions:   Drug: Ketamine;   Behavioral: Cognitive Testing;   Radiation: PET;   Device: MRI
  Sponsors:   Yale University;   VA Office of Research and Development
  Recruiting
• Effectiveness of the First French Psychoeducational Program on Unipolar Depression

  NCT02501226

  Conditions:   Unipolar Depressed Outpatients;   Mild Severity;   Without Psychotic Features
  Interventions:   Other: Treatment as usual;   Behavioral: ENVIE psychoeducational program
  Sponsors:   University Hospital, Montpellier;   Groupe Hospitalier de la Rochelle Ré Aunis;   Centre Hospitalier Universitaire de Besancon;   Centre Hospitalier Béziers;   University Hospital, Clermont-Ferrand;   Centre Hospitalier Universitaire de Nice;   Centre Hospitalier de l'Agglomération de Nevers;   Centre Psychothérapique de Nancy;   Hôpitaux à Bron;   Assistance Publique - Hôpitaux de Paris;   Centre Hospitalier Esquirol
  Recruiting
• Reducing the Rate and Duration of Re-ADMISsions Among Patients With Unipolar Disorder and Bipolar Disorder Using Smartphone-based Monitoring and Treatment - The RADMIS Trials

  NCT03033420

  Conditions:   Affective Disorders;   Unipolar Depression;   Bipolar Disorder
  Intervention:   Device: A smartphone-based monitoring system including a) an integrated feedback loop between patients and clinicians and b) context-aware CBT modules
  Sponsors:   Psychiatric Centre Rigshospitalet;   Technical University of Denmark
  Recruiting
• Studies of Brain Function and Course of Illness in Pediatric Bipolar Disorder

  NCT00025935

  Conditions:   Mood Disorder;   Bipolar Disorder
  Intervention:  
  Sponsor:   National Institute of Mental Health (NIMH)
  Recruiting
• DIMES - DIgital MEdicine Study for Adults With Schizophrenia, Bipolar I Disorder, or Major Depression Currently Using Aripiprazole

  NCT03881449

  Conditions:   Schizophrenia;   Major Depressive Disorder;   Bi-Polar Disorder;   Schizo Affective Disorder
  Intervention:   Combination Product: ABILIFY MYCITE
  Sponsors:   Durham VA Medical Center;   Otsuka Pharmaceutical Development and Commercialization, Inc.
  Recruiting
• EnBrace HR for PMS With Prominent Mood Symptoms or Menstrual Related Mood Disorders

  NCT04123483

  Conditions:   Premenstrual Syndrome;   Premenstrual Dysphoric Disorder;   Premenstrual Tension;   Menstrual Related Mood Disorder
  Intervention:   Drug: EnBrace HR Softgel
  Sponsors:   Massachusetts General Hospital;   JayMac Pharmaceuticals, LLC
  Not yet recruiting
• Targeting Adolescent Depressive Symptoms Via Brief, Web-Based Interventions

  NCT04066985

  Conditions:   Depression;   Depressive Disorder;   Behavioral Symptoms;   Mood Disorders;   Mental Disorders
  Interventions:   Behavioral: Growth Mindset Online Single-Session Program;   Behavioral: Self-Kindness Online Single-Session Program;   Behavioral: Supportive Therapy Online Single-Session Program (Control)
  Sponsors:   Child Mind Institute;   Stony Brook University
  Recruiting
• Effects of Behavioural Activation on Emotional Cognition and Mood

  NCT03995186

  Conditions:   Depression;   Depressive Disorder;   Mood Disorders;   Cognition
  Interventions:   Behavioral: Behavioural activation;   Behavioral: Activity monitoring
  Sponsor:   University of Oxford
  Recruiting
• Electronic Communication Augmented Mental Health Care

  NCT03925038

  Conditions:   Depressive Disorder;   Anxiety Disorders;   Bipolar Affective Disorder
  Interventions:   Behavioral: Augmented Care: Electronic media dashboard;   Behavioral: Treatment as Usual
  Sponsors:   Johns Hopkins University;   Once Upon a Time Foundation
  Recruiting
• Mechanisms of Rumination Change in Adolescent Depression

  NCT03859297

  Conditions:   Major Depressive Disorder;   Mood Disorders
  Interventions:   Behavioral: Rumination-Focused CBT;   Behavioral: Relaxation-based Therapy
  Sponsors:   University of Utah;   University of Exeter;   National Institute of Mental Health (NIMH)
  Not yet recruiting
• Effects of Seven Day Prucalopride Administration in Healthy Volunteers

  NCT03572790

  Conditions:   Molecular Mechanisms of Pharmacological Action;   Depression;   Depressive Disorder;   Mood Disorders;   Mental Disorders;   Antidepressive Agents;   Cognition
  Interventions:   Drug: Prucalopride;   Other: Placebo
  Sponsor:   University of Oxford
  Recruiting
• Treating Emotional Disorders in Primary Care With Psychological Techniques

  NCT01903096

  Conditions:   Anxiety Disorders;   Mood Disorders;   Somatization Disorder;   Pain Disorder
  Interventions:   Behavioral: Cognitive Behavioral Treatment;   Drug: Primary Care Treatment As Usual
  Sponsors:   Psicofundación: Fundación Española para Promoción, Desarrollo Científico y Profesional de la Psicolo;   Ministry of Health, Spain
  Recruiting
• Reaching and Engaging Depressed Senior Center Clients (REDS)

  NCT03246789

  Conditions:   Depression, Unipolar;   Mental Health Disorder
  Interventions:   Behavioral: Engage-M;   Behavioral: Wellness in Mind and Body
  Sponsors:   Weill Medical College of Cornell University;   New York City Department for the Aging;   National Institute of Mental Health (NIMH)
  Recruiting
• Mindfulness-Based Stress Reduction (MBSR) and Transcranial Direct Current Stimulation (tDCS)

  NCT03680664

  Conditions:   Anxiety Disorders;   Mood Disorders;   Transcranial Direct Current Stimulation;   tDCS;   Stress Reduction
  Interventions:   Device: Active tDCS;   Other: sham tDCS;   Behavioral: MBSR
  Sponsors:   Centre for Addiction and Mental Health;   University of Toronto
  Recruiting
• Cooperation for Primary Care Patients on Sick Leave for CMD: Care Manager and Workplace Intervention - CO-WORK-CARE

  NCT03250026

  Conditions:   Depressive Disorder;   Anxiety Disorders
  Interventions:   Behavioral: Workplace convergence dialogue;   Behavioral: Care Manager
  Sponsors:   Göteborg University;   Vastra Gotaland Region
  Recruiting
• Assisted Animal Therapy: ReAnimal

  NCT03898843

  Conditions:   Anxiety;   Mood Disorders;   Post Traumatic Stress Disorder
  Interventions:   Other: Animal assisted therapy;   Biological: Nasal swab sampling;   Behavioral: STAI-Y and POMS Questionnaires;   Procedure: physiological parameters measure;   Other: Visual Analog Scale (VAS);   Behavioral: Impact of Event Scale - Revised (IES-R);   Behavioral: satisfaction questionnaire;   Biological: Rectal swab sampling
  Sponsor:   Hospices Civils de Lyon
  Not yet recruiting
• An Eye Tracking Study of Affective Disorder Patients With Suicide Risk

  NCT03711045

  Conditions:   Major Depressive Disorder;   Bipolar Disorder;   Suicide
  Intervention:   Behavioral: eye-tracking
  Sponsor:   Central South University
  Recruiting
• Seasonal Affective Disorder and Visual Impairment

  NCT03403959

  Conditions:   Seasonal Affective Disorder;   Visual Impairment
  Intervention:   Device: light therapy
  Sponsors:   Psychiatric Centre Rigshospitalet;   Glostrup University Hospital, Copenhagen
  Recruiting
• Cannabidiol as an Adjunctive Treatment for Bipolar Depression

  NCT03310593

  Conditions:   Bipolar Disorder;   Bipolar Depression;   Bipolar Affective Disorder
  Interventions:   Drug: Cannabidiol;   Drug: Placebo
  Sponsors:   Hospital de Clinicas de Porto Alegre;   Federal University of Rio Grande do Sul;   University of Sao Paulo
  Recruiting
• Validation of an Automated Online Language Interpreting Tool - Phase Two.

  NCT03538860

  Conditions:   Mood Disorder;   Anxiety Disorder;   Substance Use Disorder;   Chronic Medical Condition
  Interventions:   Behavioral: Active comparator: Human interpreter;   Behavioral: Intervention: Asynchronous Telepsychiatry
  Sponsors:   University of California, Davis;   Agency for Healthcare Research and Quality (AHRQ)
  Recruiting
• Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy

  NCT03591224

  Conditions:   Depression;   Anxiety;   Major Depressive Disorder;   Generalized Anxiety Disorder;   Mood Disorders
  Interventions:   Other: Pharmacogenomic Testing;   Other: Pharmacist Standard of Care
  Sponsors:   John Papastergiou Pharmacy Ltd;   Green Shield Canada
  Recruiting
• Technology Enhanced Behavioral Activation Treatment for Substance Use

  NCT02707887

  Conditions:   Substance-Related Disorders;   Depressive Disorder;   Behavioral Symptoms;   Risk-Taking;   Sexual Behavior
  Interventions:   Behavioral: LETS ACT;   Behavioral: LETS ACT-SE;   Behavioral: Treatment as Usual
  Sponsors:   University of North Carolina, Chapel Hill;   National Institute on Drug Abuse (NIDA)
  Recruiting
• The Police-Mental Health Linkage System

  NCT03740139

  Conditions:   Mental Disorders, Severe;   Schizophrenia and Related Disorders;   Bipolar Disorder;   Depressive Disorder
  Intervention:   Other: The Police-Mental Health Linkage System
  Sponsors:   New York State Psychiatric Institute;   National Institute of Mental Health (NIMH)
  Recruiting
• Correlation Study Between Mental Behavioral Symptoms in Dementia Patients and Mood Disorders of Caregivers

  NCT03724344

  Condition:   Dementia
  Intervention:   Other: Cross section resaerch
  Sponsor:   Shanghai Mental Health Center
  Recruiting
• Ketamine for Mood Disorders With Suicidal Ideation

  NCT04099771

  Conditions:   Depressive Disorder, Major;   Suicidal Ideation
  Intervention:   Drug: Ketamine
  Sponsor:   The Miriam Hospital
  Recruiting
• Proactive, Personalized Postpartum Mental Healthcare

  NCT03803189

  Conditions:   Postpartum Depression;   Postpartum Blues;   Postpartum Anxiety;   Postpartum Mood Disorder
  Intervention:   Behavioral: Usual care plus eToolkit
  Sponsors:   Women's College Hospital;   Canadian Institutes of Health Research (CIHR);   North York General Hospital;   Michael Garron Hospital
  Recruiting
• Treatment With Quetiapine for Youth With Substance Use Disorders and Severe Mood Dysregulation

  NCT02845453

  Conditions:   Substance Use Disorders;   Bipolar Disorder;   Mood Disorders
  Interventions:   Drug: Quetiapine;   Drug: Placebo
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers

  NCT00024635

  Conditions:   Mood Disorder;   Anxiety Disorder;   Healthly Volunteers;   Bipolar Disorders;   Depression
  Intervention:  
  Sponsors:   National Institute of Mental Health (NIMH);   Suburban Hospital
  Recruiting
• Keeping Well:Online Cognitive Behavioral Therapy (CBT) for Pregnant Women With Depressive Symptoms

  NCT01909167

  Conditions:   Anxiety;   Mental Disorders;   Postpartum Depression;   Depressive Symptoms
  Interventions:   Behavioral: Online Cognitive Behavioral Therapy (CBT);   Other: Treatment as usual
  Sponsor:   Imperial College London
  Not yet recruiting
• Resilience in Adolescent Development

  NCT03458936

  Conditions:   Risk Assessment;   Resilience, Psychological;   Depression;   Mood Disorders;   Anxiety Disorders
  Intervention:  
  Sponsor:   University of Texas Southwestern Medical Center
  Recruiting
• Psychosocial Intervention for Women With Mood Disorders Seeking Treatment for Obesity

  NCT03743844

  Conditions:   Obesity;   Mood Disorders
  Intervention:   Behavioral: Compassion-focused psychoeducation group
  Sponsors:   Women's College Hospital;   Centre for Addiction and Mental Health;   Wharton Medical Clinic
  Not yet recruiting
• Study of Premenstrual Syndrome and Premenstrual Dysphoria

  NCT00001177

  Conditions:   PMS;   Premenstrual Mood Disorder;   PMDD;   Depression
  Intervention:  
  Sponsor:   National Institute of Mental Health (NIMH)
  Recruiting
• Continuous Theta Burst Stimulation as an add-on Treatment for Bipolar Depression

  NCT03603561

  Conditions:   Bipolar Disorder;   Bipolar Depression;   Bipolar I Disorder;   Bipolar II Disorder;   Depression;   Mood Disorders;   Mental Disorder
  Interventions:   Device: cTBS;   Device: Sham cTBS
  Sponsors:   Universiteit Antwerpen;   Universitair Ziekenhuis Brussel
  Recruiting
• e-Mindfulness for Depression

  NCT03922217

  Conditions:   Depression;   Mental Health Disorder
  Intervention:   Device: Mindful My Way
  Sponsor:   Washington University School of Medicine
  Recruiting
• Treating Smokers With Mental Illness

  NCT03822416

  Conditions:   Smoking Cessation;   Cigarette Smoking;   Schizophrenia;   Psychotic Disorders;   Major Depressive Disorder;   Bipolar Disorder I;   Bipolar II Disorder;   Mental Illness
  Interventions:   Drug: Nicotine patch;   Drug: Nicotine lozenge;   Behavioral: Therapy;   Other: Information
  Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   Hennepin County Medical Center, Minneapolis;   Brown University
  Recruiting
• A Family Depression Prevention Program

  NCT02021578

  Condition:   Depression
  Interventions:   Behavioral: Family Cognitive Behavioral Prevention;   Behavioral: Written information
  Sponsors:   Vanderbilt University;   San Diego State University
  Recruiting
• Paternal Involvement in Psychiatric Care of Adolescents Managed for Depression or Suicide Attempt

  NCT03661008

  Conditions:   Psychiatric Disorder;   Depression;   Suicide, Attempted;   Child Mental Disorder
  Intervention:  
  Sponsor:   Centre Hospitalier Universitaire de la Réunion
  Not yet recruiting
• Mobile Virtual Positive Experiences for Anhedonia

  NCT03715400

  Conditions:   Anhedonia;   Virtual Reality;   Depression;   Mood Disorders
  Intervention:   Behavioral: Positive Virtual Reality Training
  Sponsor:   University of California, Los Angeles
  Recruiting
• Mood Disorders Bladder Cancer

  NCT04036877

  Condition:   Bladder Cancer
  Intervention:   Other: Mood Disorder Assessment
  Sponsor:   University of Kansas Medical Center
  Not yet recruiting
• Appalachian Mind Health Initiative

  NCT04120285

  Condition:   Major Depressive Disorder
  Intervention:   Behavioral: remote internet-based cognitive behavior therapy (eCBT)
  Sponsors:   West Virginia University;   Patient-Centered Outcomes Research Institute
  Not yet recruiting
• Role Of Ketamine in Treatment-Resistant Major Depressive Disorder And Its Effect on Suicidality

  NCT04101474

  Condition:   Treatment Resistant Depression
  Intervention:   Drug: Ketamine
  Sponsor:   Assiut University
  Not yet recruiting
• Ketamine for Treatment Resistant MDD

  NCT04021433

  Condition:   Depressive Disorder, Major
  Intervention:   Drug: Ketamine
  Sponsor:   Hadassah Medical Organization
  Recruiting
• Mini Theta Burst TMS in MDD Patients

  NCT04014959

  Condition:   Major Depressive Disorder
  Intervention:   Combination Product: TMS/ fMRI Stimulation
  Sponsor:   University of Pennsylvania
  Recruiting
• The Role of HNKs in the Antidepressant Effect of Ketamine

  NCT03977675

  Condition:   Major Depressive Disorder
  Intervention:   Drug: Ketamine
  Sponsor:   Columbia University
  Recruiting
• Cerebellar Stroke and Mood Disorders

  NCT03515486

  Condition:   Stroke
  Intervention:   Other: Post stroke mood disorders evaluation
  Sponsor:   University Hospital, Bordeaux
  Recruiting
• Gut Feeling: Understanding the Mechanisms Underlying the Antidepressant Properties of Probiotics

  NCT03893162

  Condition:   Major Depressive Disorder
  Interventions:   Dietary Supplement: Multi-strain probiotic;   Other: Placebo
  Sponsor:   King's College London
  Recruiting
• Scopolamine in Healthy Volunteers

  NCT03874130

  Condition:   Major Depressive Disorder (MDD)
  Intervention:   Drug: Scopolamine
  Sponsor:   Repurposed Therapeutics, Inc.
  Recruiting
• Improving Brain Stimulation Through Imaging

  NCT03851380

  Conditions:   Depression;   Depressive Disorder, Treatment-Resistant
  Interventions:   Behavioral: Psychological / Functional Assessment;   Other: Structural and Functional MRI;   Device: Transcranial Magnetic Brain Stimulation and MR Image Guidance
  Sponsors:   VA Office of Research and Development;   Providence VA Medical Center;   Atlanta VA Medical Center
  Not yet recruiting
• ROOM-LIGHT: Effect of a Dynamic Lighting System in Depressed Inpatients

  NCT03821506

  Condition:   Major Depressive Disorder
  Interventions:   Device: Dynamic Light;   Device: Usual care
  Sponsors:   Mental Health Centre Copenhagen;   Mental Health Services in the Capital Region, Denmark;   Toyota-Fonden;   Grosserer L. F. Foghts Fond Denmark;   ELFORSK Danish Energy;   Technical University of Denmark
  Recruiting
• Contact: Developing New Clinical Management Strategies

  NCT03812588

  Condition:   Major Depressive Disorder
  Interventions:   Drug: Escitalopram;   Drug: Placebo
  Sponsors:   New York State Psychiatric Institute;   University of Haifa
  Recruiting
• The Role of Sex Steroids and Serotonin Brain Dynamics in Perinatal Mental Health

  NCT03795688

  Conditions:   Major Depressive Disorder;   Perinatal Depression
  Intervention:   Other: Pregnancy
  Sponsors:   Vibe G Frøkjær, MD, PhD;   Center for Integrated Molecular Brain Imaging, Copenhagen, Denmak;   Mental Health Centre Copenhagen;   University of Copenhagen
  Recruiting
• Vortioxetine in the Elderly vs. Selective Serotonin Reuptake Inhibitors (SSRIs): a Pragmatic Assessment

  NCT03779789

  Condition:   Major Depressive Disorder
  Interventions:   Drug: Vortioxetine;   Drug: Sertraline;   Drug: citalopram;   Drug: Escitalopram;   Drug: Paroxetine;   Drug: Fluoxetine;   Drug: Fluvoxamine
  Sponsors:   Azienda Ospedaliera Universitaria Integrata Verona;   University of Catania
  Not yet recruiting
• Effect of Vitamin D Administration Along With SSRIs in Patients With Major Depressive Disorder

  NCT03754712

  Condition:   MDD
  Intervention:   Dietary Supplement: Vitamin D3
  Sponsor:   Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
  Recruiting
• Efficacy and Safety of Accelerated Transcranial Magnetic Stimulation With H1-coil (dTMS)

  NCT03718013

  Condition:   Major Depressive Disorder
  Interventions:   Device: accelerated deep TMS;   Device: standard deep TMS
  Sponsor:   Sveti Ivan Psychiatric Hospital
  Recruiting
• Clinical, Neurocognitive, and Emotional Effects of Psilocybin in Depressed Patients - Proof of Concept

  NCT03715127

  Condition:   Depressive Disorder, Major
  Interventions:   Drug: Psilocybine oral capsule;   Drug: Placebo oral capsule
  Sponsors:   University of Zurich;   Schweizerischer Nationalfonds
  Recruiting
• Maintenance of Response After rTMS for Depression Using tDCS

  NCT03708159

  Condition:   Major Depressive Disorder
  Interventions:   Device: active tDCS + mindfulness meditation;   Other: sham tDCS + mindfulness meditation
  Sponsors:   Centre for Addiction and Mental Health;   University Health Network, Toronto
  Recruiting
• Ketamine Co-induction for Patients With Major Depressive Disorder

  NCT03666494

  Conditions:   Ketamine;   Depression;   Anesthesia
  Interventions:   Drug: Ketamine Hydrochloride;   Drug: Propofol;   Drug: Fentanyl
  Sponsor:   University of Saskatchewan
  Not yet recruiting
• Transcranial Magnetic Stimulation Study of Cortical Excitability as Marker of Antidepressant Response: EXCIPSY Study

  NCT03606850

  Condition:   Major Depressive Disorder
  Intervention:   Device: Measurements of markers of cortical excitability by TMS
  Sponsors:   Centre Hospitalier du Rouvray;   Centre hospitalier de Ville-Evrard, France;   University Hospital Caen, France
  Recruiting
• Modeling Multi-level Dyadic Behavior to Transform the Science and Practice of Psychotherapy Process and Outcome.

  NCT03594773

  Condition:   Major Depressive Disorder
  Interventions:   Behavioral: Cognitive Behavioral Therapy;   Behavioral: Interpersonal Psychotherapy
  Sponsors:   University of Pittsburgh;   Carnegie Mellon University
  Recruiting
• Pharmacogenetics Informed Tricyclic Antidepressant Dosing (PITA)

  NCT03548675

  Condition:   Depressive Disorder, Major
  Intervention:   Drug: TCA treatment
  Sponsors:   Radboud University;   ZonMw: The Netherlands Organisation for Health Research and Development
  Recruiting
• tDCS as add-on Treatment to Cognitive-Behavior Therapy in People With MDD

  NCT03548545

  Conditions:   Major Depressive Disorder;   CBT;   Transcranial Direct Current Stimulation
  Intervention:   Device: tDCS
  Sponsors:   University of Minho;   Fundação para a Ciência e a Tecnologia
  Recruiting
• Switching From SSRI to Desvenlafaxine on Cognitive Functioning

  NCT03432221

  Condition:   Major Depressive Disorder
  Intervention:   Drug: Desvenlafaxine
  Sponsors:   Corporacion Parc Tauli;   Pfizer
  Recruiting
• Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response

  NCT03367533

  Condition:   Depressive Disorder, Major
  Interventions:   Drug: Ketamine;   Drug: Perampanel;   Drug: Placebo
  Sponsor:   Yale University
  Recruiting
• McLean and Genomind Prospective Study

  NCT03113890

  Conditions:   Major Depressive Disorder;   PTSD
  Interventions:   Genetic: Phlebotomy - Folate;   Genetic: Cheek Swab;   Other: Self-report surveys
  Sponsors:   Mclean Hospital;   Genomind, LLC
  Recruiting
• Rapid Antidepressant Effects of Leucine

  NCT03079297

  Condition:   Major Depressive Disorder
  Interventions:   Drug: L-Leucine;   Other: Maltodextrin
  Sponsor:   University of Texas Southwestern Medical Center
  Recruiting
• Neurobiology of Treatment Responses in MDD

  NCT03068247

  Condition:   Major Depressive Disorder
  Interventions:   Drug: Duloxetine;   Drug: Placebo
  Sponsor:   University of Utah
  Not yet recruiting
• Comparative Effectiveness Research Trial for Antidepressant Incomplete and Non-responders With TRD

  NCT02977299

  Condition:   Treatment Resistant Major Depressive Disorder
  Interventions:   Drug: Aripiprazole;   Device: Repetitive transcranial magnetic stimulation (rTMS);   Drug: Venlafaxine XR
  Sponsors:   Massachusetts General Hospital;   Patient-Centered Outcomes Research Institute
  Recruiting
• Personalized rTMS for Resistant Depression

  NCT02863380

  Conditions:   Depressive Disorder;   Treatment-Resistant
  Interventions:   Procedure: Functional magnetic resonance imaging used to individualize rTMS protocol;   Device: Individualized rTMS (transcranial magnetic stimulation);   Device: Classical rTMS (transcranial magnetic stimulation);   Device: Classical tDCS (transcranial direct current stimulation)
  Sponsor:   University Hospital, Strasbourg, France
  Recruiting
• Loneliness and Occurrence of Suicide Attemps and Suicidal Ideas

  NCT02829671

  Condition:   Major Depressive Disorders
  Intervention:   Other: Clinical and biological assessment
  Sponsor:   University Hospital, Montpellier
  Not yet recruiting
• Neuropsychological Factors Associated With Vulnerability to Suicidal Behavior in Depressed Elderly Patients

  NCT02737540

  Condition:   Depressive Disorder, Major
  Intervention:  
  Sponsor:   Centre Hospitalier Universitaire de Nīmes
  Recruiting
• Supportive and Supportive-Expressive Treatment for Depression

  NCT02728557

  Condition:   Major Depressive Disorder
  Interventions:   Behavioral: Supportive-Expressive Therapy;   Behavioral: Supportive Therapy
  Sponsor:   University of Haifa
  Recruiting
• Study of Neural Responses Induced by Antidepressant Effects

  NCT02674529

  Condition:   Major Depressive Disorder
  Interventions:   Drug: Escitalopram;   Drug: Placebo
  Sponsor:   University of Pittsburgh
  Recruiting
• Intra-nasal vs. Intra-venous Ketamine Administration

  NCT02644629

  Condition:   Major Depressive Disorder
  Interventions:   Drug: Placebo;   Drug: Ketamine (1st phase);   Drug: Ketamine (2st phase)
  Sponsor:   Shalvata Mental Health Center
  Recruiting
• MetAbolism vaRiability of VEnLafaxine

  NCT02590185

  Condition:   Major Depressive Disorders
  Intervention:   Drug: cocktail probe drugs
  Sponsor:   Assistance Publique - Hôpitaux de Paris
  Recruiting
• miRNAs, Suicide, and Ketamine - Plasma Exosomal microRNAs as Novel Biomarkers for Suicidality and Treatment Outcome

  NCT02418195

  Condition:   Major Depressive Disorder
  Intervention:   Drug: ketamine
  Sponsors:   University of Alabama at Birmingham;   National Institute of Mental Health (NIMH)
  Recruiting
• Connectivity Affecting the Antidepressant REsponse Study

  NCT02332291

  Condition:   Major Depressive Disorder
  Interventions:   Drug: Escitalopram;   Drug: Bupropion XL
  Sponsor:   Vanderbilt University Medical Center
  Recruiting
• Treating Depression on a Day-to-day Basis: Development of a Tool for Physicians Based on a Smartphone Application

  NCT03678194

  Conditions:   Depression;   Psychiatric Disorder;   Brain Diseases;   Central Nervous System Diseases;   Nervous System Diseases
  Intervention:   Device: Smartphone Support System
  Sponsor:   Centre Hospitalier Charles Perrens, Bordeaux
  Not yet recruiting
• Effects of a Tissue Selective Estrogen Complex (TSEC) on Depression and the Neural Reward System in the Perimenopause"

  NCT03740009

  Conditions:   Perimenopausal Disorder;   Depression
  Intervention:   Drug: Bazedoxifene/Conjugated Estrogen
  Sponsors:   University of North Carolina, Chapel Hill;   Foundation of Hope, North Carolina
  Recruiting
• SMART-DAPPER: Leveraging the Depression And Primary-care Partnership for Effectiveness-implementation Research Project

  NCT03466346

  Conditions:   Depression, Unipolar;   Posttraumatic Stress Disorder;   Trauma
  Interventions:   Drug: Fluoxetine;   Behavioral: Interpersonal Psychotherapy
  Sponsors:   University of California, San Francisco;   University of Nairobi;   National Institute of Mental Health (NIMH);   Kenya Medical Research Institute;   University of California, San Diego;   Makerere University
  Not yet recruiting
• Comparing Engage to PST for Late Life Depression

  NCT02086201

  Condition:   Major Depression
  Interventions:   Behavioral: Problem Solving Therapy;   Behavioral: Engage
  Sponsors:   University of Washington;   Weill Medical College of Cornell University
  Recruiting
• Lipopolysaccharide (LPS) Challenge in Depression

  NCT03142919

  Condition:   Major Depressive Disorder
  Interventions:   Biological: Lipopolysaccharide;   Biological: Placebo
  Sponsor:   Laureate Institute for Brain Research, Inc.
  Recruiting
• Evaluation of the Genetics of Bipolar Disorder

  NCT00001174

  Conditions:   Mania;   Bipolar, Disorder;   Depression;   Mood Disorder;   Schizoaffective;   Manic Depression
  Intervention:  
  Sponsor:   National Institute of Mental Health (NIMH)
  Recruiting
• Characterization and Treatment of Adolescent Depression

  NCT03388606

  Condition:   Depression
  Intervention:  
  Sponsor:   National Institute of Mental Health (NIMH)
  Recruiting
• Step Away From Depression - Evaluation of a Pedometer Intervention With Inpatients With Major Depression

  NCT02850341

  Condition:   Depression
  Intervention:   Device: Pedometer
  Sponsor:   Charite University, Berlin, Germany
  Recruiting
• The Unified Protocol for the Treatment of Emotional Disorders in Spanish Public Mental Health System

  NCT03064477

  Conditions:   Emotional Disorder;   Anxiety Disorders;   Depressive Disorder
  Interventions:   Behavioral: Unified Protocol;   Behavioral: Cognitive Behavioral Therapy (TAU)
  Sponsors:   Universitat Jaume I;   Universidad de Zaragoza
  Recruiting
• A Study of Aerobic Exercise for Patients With Bipolar Disorder

  NCT03353337

  Conditions:   Bipolar Disorder;   Cognitive Symptom
  Interventions:   Behavioral: aerobic exercise;   Behavioral: Placebo controlled group
  Sponsor:   Guangzhou Psychiatric Hospital
  Not yet recruiting
• Reward Function and Therapy for Late-Life Depression

  NCT03688139

  Condition:   Major Depressive Disorder
  Interventions:   Behavioral: Engage Therapy;   Behavioral: Supportive Therapy
  Sponsors:   Weill Medical College of Cornell University;   National Institute of Mental Health (NIMH)
  Recruiting
• Chronobiology, Sleep Related Risk Factors and Light Therapy in Perinatal Depression: the Life-ON Project

  NCT02664467

  Conditions:   Depression;   Depression, Postpartum;   Depressive Disorder;   Depressive Disorder, Major;   Mood Disorders;   Pregnancy Complications;   Puerperal Disorders
  Intervention:   Device: Philips EnergyUp EnergyLight HF3419/01
  Sponsors:   Ospedale Regionale di Lugano;   University of Bologna;   University of Milan;   University of Turin, Italy
  Recruiting
• Promoting Enhanced Pharmacotherapy Choice Through Immunomarkers Evaluation in Depression

  NCT03993457

  Condition:   Depression
  Interventions:   Drug: Escitalopram;   Drug: Bupropion
  Sponsor:   University of Texas Southwestern Medical Center
  Recruiting
• Evaluation of mHealth for Serious Mental Illness

  NCT04068467

  Conditions:   Schizophrenia;   Schizoaffective Disorder;   Bipolar Disorder;   Major Depressive Disorder
  Interventions:   Other: Smartphone App;   Other: Waitlist Control
  Sponsor:   University of Washington
  Not yet recruiting
• Research of Anatomo-functional Biomarkers in Schizophrenia

  NCT03996122

  Condition:   Schizophrenia
  Intervention:   Other: fMRI
  Sponsor:   University Hospital, Caen
  Recruiting
• Effect of 4-session Metacognitive Training in Chinese Adult Outpatients With Schizophrenia Spectrum Disorders and Major Depressive Disorder

  NCT03449394

  Conditions:   Delusions;   Depression
  Intervention:   Other: Metacognitive Training
  Sponsor:   Chinese University of Hong Kong
  Recruiting
• Affective Touching on Poststroke Depression

  NCT03789994

  Condition:   Post-stroke Depression
  Interventions:   Behavioral: Affective touch;   Other: Fine motor exercise
  Sponsors:   Chinese University of Hong Kong;   Research Grants Council
  Not yet recruiting
• Minocycline Hydrochloride in Reducing Chemotherapy Induced Depression and Anxiety in Patients With Stage I-III Breast Cancer

  NCT02203552

  Conditions:   Anxiety Disorder;   Depression;   Recurrent Breast Cancer;   Stage IA Breast Cancer;   Stage IB Breast Cancer;   Stage II Breast Cancer;   Stage IIIA Breast Cancer;   Stage IIIB Breast Cancer;   Stage IIIC Breast Cancer
  Interventions:   Drug: minocycline hydrochloride;   Other: placebo;   Other: laboratory biomarker analysis;   Other: Questionnaire administration
  Sponsor:   Ohio State University Comprehensive Cancer Center
  Recruiting
• Nitrous Oxide for the Treatment of Major Depressive Disorder

  NCT03869736

  Conditions:   Depression;   Major Depressive Disorder
  Interventions:   Drug: Nitrous Oxide;   Drug: Placebo
  Sponsor:   Bayside Health
  Recruiting
• A Study of JNJ-61393215 in the Treatment of Depression

  NCT04080752

  Condition:   Major Depressive Disorder With Anxious Distress
  Interventions:   Drug: JNJ-61393215;   Drug: Placebo
  Sponsor:   Janssen Research & Development, LLC
  Recruiting
• Controlled Study to Evaluate the Safety and Efficacy of the Predictix Antidepressant Clinician Support Tool

  NCT04031157

  Condition:   Major Depressive Disorder
  Intervention:   Device: Predictix Antidepressant
  Sponsor:   Taliaz Ltd.
  Recruiting
• Efficacy of Eye Movement Desensitization & Reprocessing Versus Cognitive Behavioral Therapy in Post-Traumatic Stress and Depressive Disorders

  NCT04021329

  Condition:   Efficacy of Psychotherapy
  Intervention:   Behavioral: CBT Therapy
  Sponsor:   Khushal Khan Khattak Univeristy, Karak, Pakistan
  Not yet recruiting
• Mechanism of Action of tACS for the Treatment of MDD

  NCT03994081

  Conditions:   Major Depressive Disorder;   MDD
  Interventions:   Device: tACS;   Device: Sham tACS
  Sponsors:   University of North Carolina, Chapel Hill;   Foundation of Hope for Research and Treatment of Mental Illness
  Not yet recruiting
• Study With Vortioxetine on Emotional Functioning in Patients With Depression

  NCT03835715

  Condition:   Major Depressive Disorder
  Intervention:   Drug: Vortioxetine
  Sponsor:   H. Lundbeck A/S
  Recruiting
• to Explore the Effective Doses, and to Assess the Safety and Efficacy of Hypidone Hydrochloride Tablets

  NCT03739632

  Condition:   Major Depressive Disorder
  Interventions:   Drug: Hypidone Hydrochloride tablets;   Other: Placebo
  Sponsor:   Shanghai Synergy Pharmaceutical Sciences Co., Ltd.
  Not yet recruiting
• Group Metacognitive Therapy vs Clinical Management for Depression

  NCT03711123

  Condition:   Major Depressive Disorder
  Interventions:   Behavioral: Group metacognitive therapy;   Behavioral: Clinical management
  Sponsor:   University of Oslo
  Recruiting
• The Antidepressant Advisor Study

  NCT03628027

  Condition:   Major Depressive Disorder
  Intervention:   Device: Computerised decision support algorithm
  Sponsors:   King's College London;   NHS Lambeth Clinical Commissioning Group;   EMIS PLC;   D'Or Institute for Research and Education
  Recruiting
• Intervention to Prevent Peer Violence & Depressive Symptoms Among At-Risk Adolescents

  NCT03626103

  Conditions:   Depressive Disorder;   Violence
  Interventions:   Behavioral: + Brief ED Intervention (BI);   Behavioral: + Text
  Sponsors:   Rhode Island Hospital;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
  Recruiting
• Olfactory Training and Emotional State

  NCT03605524

  Conditions:   Depressive Symptoms;   Depressive Disorder, Major
  Intervention:   Other: Sensory training
  Sponsor:   University Hospital, Tours
  Recruiting
• A Study to Explore the Efficacy of JNJ-67953964 in the Treatment of Depression

  NCT03559192

  Condition:   Depressive Disorder, Major
  Interventions:   Drug: JNJ-67953964;   Drug: Placebo
  Sponsor:   Janssen Research & Development, LLC
  Recruiting
• Real-life Effectiveness of Vortioxetine in Depression

  NCT03555136

  Condition:   Major Depressive Disorder
  Intervention:   Drug: Vortioxetine
  Sponsor:   H. Lundbeck A/S
  Recruiting
• Cycloserine rTMS Plasticity Augmentation in Depression

  NCT03511599

  Condition:   Major Depressive Disorder
  Interventions:   Drug: Cycloserine;   Device: Transcranial Magnetic Stimulation;   Drug: Placebo Oral Tablet
  Sponsor:   University of Calgary
  Recruiting
• To Explore the Safety and Efficacy of Hypidone Hydrochloride Tablets in Treatment of Patients With MDD

  NCT03404466

  Condition:   Major Depressive Disorder
  Intervention:   Drug: Hypidone Hydrochloride tablets
  Sponsor:   Shanghai Synergy Pharmaceutical Sciences Co., Ltd.
  Recruiting
• Movement for Depression - An RCT Assessing the Effects of Physical Activity Promotion for People With MDD

  NCT03403881

  Condition:   Major Depressive Disorder
  Interventions:   Behavioral: Physical activity promotion + TAU;   Behavioral: Control
  Sponsor:   Hospital de Clinicas de Porto Alegre
  Recruiting
• Evolution of Dark Ideas When Introducing or Switching an Antidepressant

  NCT03327974

  Condition:   Current Major Depressive Disorder
  Intervention:   Other: DEPASSE Apllication
  Sponsor:   University Hospital, Montpellier
  Recruiting
• Cerebral Neuroinflammation During Major Depressive Episode

  NCT03314155

  Condition:   Depressive Disorder
  Intervention:   Diagnostic Test: Cerebral neuroinflammation evaluation
  Sponsors:   University Hospital, Toulouse;   Institut National de la Santé Et de la Recherche Médicale, France
  Recruiting
• Concurrent fMRI-guided rTMS and Cognitive Therapy for the Treatment of Major Depressive Episodes

  NCT03289923

  Condition:   Major Depressive Disorder
  Interventions:   Other: TMS+SST;   Other: Sham TMS + Sham Therapy;   Device: TMS;   Behavioral: Cogntive Therapy
  Sponsor:   National Institute of Mental Health (NIMH)
  Recruiting
• Effects of Schema Therapy vs. Cognitive Behavioral Therapy in Patients With Depression

  NCT03287362

  Condition:   Major Depressive Disorder
  Interventions:   Behavioral: schema therapy;   Behavioral: cognitive behavioral therapy;   Behavioral: individualized supportive therapy
  Sponsors:   Max-Planck-Institute of Psychiatry;   Ludwig-Maximilians - University of Munich
  Recruiting
• ECT Pulse Amplitude and Medial Temporal Lobe Engagement

  NCT02999269

  Condition:   Major Depressive Disorder
  Intervention:   Device: MECTA Spectrum 5000Q Amplitude
  Sponsors:   University of New Mexico;   The Mind Research Network;   University of Texas;   National Institute of Mental Health (NIMH)
  Recruiting
• Effects of Amygdala Neurofeedback on Depressive Symptoms

  NCT02709161

  Condition:   Major Depressive Disorder
  Interventions:   Behavioral: real-time fMRI neurofeedback: Amygdala;   Behavioral: real-time fMRI neurofeedback: HIPS
  Sponsor:   University of Pittsburgh
  Recruiting
• Korean Post Marketing Surveillance to Observe Effectiveness and Safety of PRISTIQ

  NCT02548949

  Condition:   Major Depressive Disorder
  Intervention:  
  Sponsor:   Pfizer
  Recruiting
• Adjunct Minocyline in Treatment-resistant Depression

  NCT02456948

  Condition:   Major Depressive Disorder
  Interventions:   Drug: Minocycline;   Drug: Placebo
  Sponsor:   Charite University, Berlin, Germany
  Recruiting
• Cognitive Behavior Therapy for Depression Depression

  NCT01868711

  Condition:   Major Depressive Disorder
  Intervention:   Behavioral: Cognitive Behavior Therapy
  Sponsor:   New York State Psychiatric Institute
  Recruiting
• Study to Evaluate the Safety and Efficacy of PEER Interactive Versus Treatment as Usual in Subjects With a Primary Diagnosis of Depression

  NCT01794559

  Condition:   Depressive Disorder
  Intervention:   Device: PEER Interactive Report
  Sponsor:   CNS Response
  Recruiting
• EpCS in Severe Treatment Resistant Depression

  NCT04124341

  Condition:   Treatment Resistant Depression
  Intervention:   Device: Epidural Prefrontal Cortical Stimulation (EpCS)
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Not yet recruiting
• Feasibility of Internet-delivered CBT for Adolescents With Depression

  NCT04117789

  Condition:   Major Depressive Disorder
  Interventions:   Behavioral: Therapist-guided internet-delivered cognitive behavior therapy for depression in adolescents;   Behavioral: Self-guided internet-delivered cognitive behavior therapy for depression in adolescents;   Other: Treatment as usual
  Sponsors:   Karolinska Institutet;   Stockholm County Council, Sweden
  Not yet recruiting
• FASTLANE II: Reducing Sex, Drug, and Mental Health Risk

  NCT04109014

  Conditions:   Methamphetamine Abuse;   HIV/AIDS;   Depression;   Sex, Unsafe
  Intervention:   Other: FASTLANE II
  Sponsors:   University of Southern California;   University of California, San Diego
  Not yet recruiting
• Adolescent Attention to Emotion Study

  NCT04105868

  Condition:   Depression
  Intervention:   Other: Neurofeedback
  Sponsors:   University of Pittsburgh;   National Institute of Mental Health (NIMH)
  Recruiting
• Enhanced Spatial Targeting in ECT Utilizing FEAST

  NCT04099342

  Condition:   Treatment Resistant Depression
  Interventions:   Device: FEAST;   Device: FEAST RP;   Device: FEAST RC
  Sponsor:   University of Minnesota - Clinical and Translational Science Institute
  Not yet recruiting
• Depression, Trauma, and Health: Efficacy of an mHealth App for Symptom Self-Management in College Students

  NCT04094792

  Condition:   Depression
  Intervention:   Device: Happify Breather App
  Sponsors:   University of Kentucky;   Happify Inc.
  Not yet recruiting
• Improving Preschool Outcomes by Addressing Maternal Depression in Head Start

  NCT04092010

  Condition:   Maternal Depression
  Interventions:   Behavioral: Problem-solving education (PSE);   Behavioral: Engagement sessions;   Behavioral: Usual care
  Sponsors:   Boston Medical Center;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
  Not yet recruiting
• Ketamine Treatment Effects on Synaptic Plasticity in Depression

  NCT04091971

  Condition:   Major Depressive Disorder
  Intervention:   Drug: Ketamine
  Sponsor:   New York State Psychiatric Institute
  Not yet recruiting
• Ketamine Interleaved With Electroconvulsive Therapy for Depression

  NCT04082858

  Condition:   Depression
  Interventions:   Drug: Ketamine;   Drug: Midazolam
  Sponsor:   St Patrick's Hospital, Ireland
  Not yet recruiting
• Neurofeedback In Treatment Resistant Depression

  NCT04078438

  Conditions:   Depression;   Neurofeedback
  Interventions:   Device: neurofeedback augmentation;   Drug: treatment as usual;   Other: psychotherapy placebo sessions
  Sponsor:   Yeungnam University Hospital
  Recruiting
• The Use of Collaborative Care in General Practice for Elderly Patients With Depression

  NCT04078282

  Condition:   Depression in Old Age
  Intervention:   Behavioral: Intervention group
  Sponsor:   University of Oslo
  Not yet recruiting
• Brain-derived Neurotrophic Factor and the Antidepressant Efficacy of Brain Stimulation

  NCT04076124

  Condition:   Treatment Resistant Depression
  Interventions:   Device: Active rTMS-DLPFC;   Device: Active iTBS-DLPFC;   Device: Sham TBS-DLPFC or Sham rTMS-DLPFC
  Sponsor:   Taipei Veterans General Hospital, Taiwan
  Recruiting
• Lifestyle Medicine for Depression 2019

  NCT04070417

  Condition:   Depression
  Intervention:   Behavioral: Lifestyle Medicine
  Sponsors:   Chinese University of Hong Kong;   University of Melbourne;   University of Western Sydney
  Not yet recruiting
• Behavioral Activation Therapy for Medical Students With Symptoms of Depression in Two Cities of Mexico

  NCT04069182

  Condition:   Depression, Anxiety
  Intervention:   Behavioral: Behavioral Activation Therapy
  Sponsors:   Universidad Autonoma de Baja California;   Universidad Autonoma de Ciudad Juarez;   Universidad Nacional Autonoma de Mexico
  Recruiting
• Development of a Predictive Index for Probable Depression Among Secondary School Students

  NCT04063202

  Conditions:   Depression;   Stress;   Youth
  Intervention:   Other: Observation
  Sponsor:   Chinese University of Hong Kong
  Not yet recruiting
• A Feasibility Study of an AI-Powered Clinical Decision Aid for Personalized Depression Treatment Selection

  NCT04061642

  Condition:   Depression
  Intervention:   Device: Clinical Decision Aid
  Sponsor:   Aifred Health Inc.
  Recruiting
• Near Infrared Spectroscopy (NIRS) for Assessment of Depression

  NCT04061148

  Condition:   Major Depressive Disorder
  Intervention:   Device: NIRSIT
  Sponsors:   University of California, San Francisco;   Obelab Inc.;   San Francisco Veterans Affairs Medical Center
  Recruiting
• Internet-based Cognitive Behavioural Therapy for Cardiac Patients

  NCT04053244

  Conditions:   Depression;   Cardiovascular Diseases
  Intervention:   Behavioral: internet-based cognitive behavioural therapy
  Sponsor:   University of British Columbia
  Recruiting
• The Safety, Efficacy, and Tolerability of Microbial Ecosystem Therapeutic-2 in People With Major Depression and/or Generalized Anxiety Disorder

  NCT04052451

  Condition:   Depression, Anxiety
  Intervention:   Biological: MET-2
  Sponsor:   NuBiyota
  Recruiting
• Biomarker-guided rTMS for Treatment Resistant Depression

  NCT04041479

  Conditions:   Treatment Resistant Depression;   Major Depressive Disorder
  Intervention:   Device: Repetitive Transcranial Magnetic Stimulation
  Sponsors:   Weill Medical College of Cornell University;   National Institute of Mental Health (NIMH);   University of Toronto
  Not yet recruiting
• Open-Label Safety Study of AXS-05 in Subjects With Depression

  NCT04039022

  Conditions:   Major Depressive Disorder;   Treatment Resistant Depression;   Depression
  Intervention:   Drug: AXS-05
  Sponsor:   Axsome Therapeutics, Inc.
  Recruiting
• Dorsomedial Prefrontal Cortex and the Antidepressant Efficacy of Theta Burst Stimulation in Depressed Patients

  NCT04037592

  Condition:   Treatment Resistant Depression
  Interventions:   Device: Active standardized iTBS-DMPFC;   Device: Active high-dosage iTBS-DMPFC;   Device: Sham standardized iTBS-DMPFC or high-dosage iTBS-DMPFC
  Sponsor:   Taipei Veterans General Hospital, Taiwan
  Recruiting
• Clinical Study of Escitalopram Oxalate Combined With taVNS in Depression and Concomitant Inflammatory Symptoms

  NCT04037111

  Conditions:   Major Depressive Disorder;   Rheumatoid Arthritis
  Interventions:   Device: Transcutaneous electrical vagus nerve stimulation;   Device: Sham vagus nerve stimulation;   Drug: drug treatment
  Sponsor:   Xijing Hospital
  Recruiting