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• Ocrelizumab for Psychosis by Autoimmunity

  NCT03971487

  Conditions:   Schizo-Affective Type of Psychosis;   Schizophrenia
  Interventions:   Behavioral: Psychosis and cognitive assessments;   Behavioral: Physical and neuro-cognitive evaluations;   Diagnostic Test: Safety labs and electrocardiogram;   Biological: Ocrelizumab infusion
  Sponsors:   The Methodist Hospital System;   Genentech, Inc.
  Recruiting
• A Controlled Study With Remote Web-based Adapted Physical Activity (e-APA) in Psychotic Disorders

  NCT03261817

  Conditions:   Schizophrenia;   Physical Activity;   Schizo Affective Disorder
  Interventions:   Behavioral: Physical activity (APA);   Behavioral: Health Education program (HE)
  Sponsors:   University Hospital, Caen;   Centre Hospitalier du Rouvray
  Recruiting
• Correlational Explorations Between Clinical Recovery and Personal Recovery

  NCT04125030

  Conditions:   Psychotic Disorders;   Mood Disorders
  Intervention:   Other: Validation of questionnaires
  Sponsors:   Jean-Francois Pelletier;   Yale University
  Recruiting
• Levetiracetam in Early Psychosis

  NCT03129360

  Conditions:   Psychosis;   Schizophrenia;   Schizo Affective Disorder;   Schizophreniform
  Intervention:   Drug: Levetiracetam
  Sponsors:   NYU Langone Health;   National Institutes of Health (NIH)
  Recruiting
• Effects of Intranasal Insulin on Neuroimaging Markers and Cognition in Patients With Psychotic Disorders

  NCT03943537

  Conditions:   Psychosis;   Schizophrenia;   Schizo Affective Disorder;   Bipolar I Disorder
  Intervention:   Drug: Intranasal Insulin
  Sponsor:   Mclean Hospital
  Not yet recruiting
• CBT-I as Early Intervention of Mood Disorders

  NCT03000894

  Condition:   Insomnia Due to Mental Disorder
  Intervention:   Behavioral: Cognitive Behavioral Therapy for Insomnia (CBT-I)
  Sponsors:   The University of Hong Kong;   Kowloon Hospital, Hong Kong
  Not yet recruiting
• L-arginine Study for Persistent Symptoms of Schizophrenia

  NCT04054973

  Conditions:   Schizo Affective Disorder;   Schizophrenia
  Interventions:   Drug: L-arginine;   Drug: Sapropterin Dihydrochloride
  Sponsor:   University of Massachusetts, Worcester
  Recruiting
• Financial Incentives to Improve Acceptance of Antipsychotic Injections

  NCT03192631

  Conditions:   Schizophrenia;   Schizo Affective Disorder;   Bipolar I Disorder
  Intervention:   Other: Financial incentive
  Sponsor:   Focus Community Mental Health Team
  Not yet recruiting
• Cromoglycate Adjunctive Therapy for Outpatients With Schizophrenia

  NCT03794076

  Conditions:   Schizophrenia;   Schizo Affective Disorder
  Interventions:   Drug: Cromoglycate;   Drug: Placebo
  Sponsors:   Vishwajit Nimgaonkar, MD PhD;   Stanley Medical Research Institute
  Recruiting
• D-serine Augmentation of Neuroplasticity

  NCT03711500

  Conditions:   Schizophrenia;   Schizo Affective Disorder
  Interventions:   Drug: D-serine;   Drug: Placebo
  Sponsors:   New York State Psychiatric Institute;   Nathan Kline Institute for Psychiatric Research
  Recruiting
• Cognitive Effects of Nimodipine in Patients With Schizophrenia

  NCT03671525

  Conditions:   Schizophrenia;   Schizo Affective Disorder
  Interventions:   Drug: Nimodipine;   Drug: Placebo oral capsule
  Sponsor:   Johns Hopkins University
  Recruiting
• Virtual Reality Avatar Therapy for People Hearing Voices

  NCT04099940

  Conditions:   Psychosis;   Schizophrenia;   Schizo Affective Disorder;   Hearing Voices When No One is Talking (Symptom)
  Interventions:   Behavioral: Virtual Reality Avatar Therapy (VRAT);   Behavioral: Assertiveness Training Program (ATP)
  Sponsor:   Psychiatric University Hospital, Zurich
  Not yet recruiting
• Reproductive Life Planning for Women With Mental Illness

  NCT03969589

  Conditions:   Psychotic Disorders;   Mood Disorders;   Stress Disorders, Post-Traumatic
  Interventions:   Behavioral: Reproductive Life Planning-Mental Health (RLP-MH) Intervention;   Other: Written Materials on Reproductive Life Planning
  Sponsor:   VA Office of Research and Development
  Recruiting
• Virtual Reality Training for Social Skills in Schizophrenia - Comparison With Cognitive Training

  NCT04005794

  Conditions:   Schizophrenia;   Schizo Affective Disorder;   Social Skills
  Interventions:   Behavioral: VR social skills training;   Behavioral: Cognitive training
  Sponsor:   Vanderbilt University
  Not yet recruiting
• Telmisartan Pilot Study on Treatment Resistant Schizophrenia

  NCT03868839

  Conditions:   Schizophrenia;   Schizo Affective Disorder;   Treatment-resistant Schizophrenia
  Intervention:   Drug: Telmisartan Pill
  Sponsor:   Xiaoduo Fan
  Recruiting
• Confirmatory Efficacy Trial of a Gluten-Free Diet in a Subgroup of Persons With Schizophrenia Who Have High Levels of IgG Anti-Gliadin Antibodies (AGA IG)

  NCT03183609

  Conditions:   Schizophrenia;   Gluten Sensitivity;   Schizo Affective Disorder
  Interventions:   Other: Gluten Flour in Protein Shake;   Other: Rice Flour in Protein Shake
  Sponsor:   University of Maryland, Baltimore
  Recruiting
• Multi-modal Assessment of Gamma-aminobutyric Acid (GABA) Function in Psychosis

  NCT04004416

  Conditions:   Schizophrenia;   Bipolar Disorder;   Healthy;   Psychosis;   Schizophreniform Disorders;   Schizo Affective Disorder
  Interventions:   Other: Placebo and fMRI;   Drug: Lorazepam and fMRI
  Sponsors:   University of Michigan;   National Institute of Mental Health (NIMH)
  Not yet recruiting
• Early Psychosis Intervention - Spreading Evidence-based Treatment

  NCT03919760

  Conditions:   First Episode Psychosis;   Schizophrenia, Childhood;   Psychosis;   Schizophrenia;   Schizoaffective Disorder;   Schizophreniform Disorders;   Bipolar I Disorder;   Schizophrenia Spectrum and Other Psychotic Disorders;   Affective Disorders, Psychotic;   Psychotic Disorder Due to Unspecified Substance
  Intervention:   Behavioral: NAVIGATE
  Sponsors:   Centre for Addiction and Mental Health;   Canadian Institutes of Health Research (CIHR);   Institute for Clinical Evaluative Sciences;   North Bay Regional Health Centre;   Health Sciences North;   Niagara Region Public Health;   Lakeridge Health Corporation
  Not yet recruiting
• Assessment and Treatment for Chronic Pain in Veterans With Serious Mental Illness

  NCT04118283

  Conditions:   Chronic Pain;   Schizophrenia;   Psychotic Disorders;   Bipolar Disorder;   Affective Disorders, Psychotic
  Interventions:   Behavioral: Cognitive Behavioral Therapy for Chronic Pain;   Behavioral: Health and Wellness
  Sponsors:   VA Office of Research and Development;   VA Maryland Health Care System
  Not yet recruiting
• Mental Health in Refugees and Asylum Seekers

  NCT03109028

  Condition:   Affective Disorders
  Interventions:   Behavioral: Peer-to-Peer-Groupintervention;   Behavioral: Smartphone-based-Intervention;   Behavioral: Gendersensitive-Groupintervention;   Behavioral: Empowerment-Groupintervention;   Behavioral: Adolescent-Groupintervention;   Other: Treatment as Ususal
  Sponsors:   Charite University, Berlin, Germany;   Zentralinstitut für Seelische Gesundheit Mannheim;   University of Potsdam;   University of Ulm;   Philipps University Marburg Medical Center;   RWTH Aachen University;   Ludwig-Maximilians - University of Munich
  Recruiting
• A Study of Pregnant and Postpartum Women With and Without Mood Disorders

  NCT03615794

  Conditions:   Bipolar Disorder;   Major Depressive Disorder;   Postpartum Depression;   Postpartum Psychosis
  Intervention:  
  Sponsor:   Johns Hopkins University
  Recruiting
• Effectiveness of Using the Progressive Goal Attainment Program in Anxiety and Mood Disorders

  NCT02819986

  Conditions:   Anxiety;   Mood Disorder
  Intervention:   Behavioral: Progressive Goal Attainment Program
  Sponsor:   St. Joseph's Healthcare Hamilton
  Recruiting
• Bazedoxifene -Treatment for Women With Schizophrenia

  NCT04113993

  Conditions:   Schizophrenia;   Schizophreniform Disorders;   Schizo Affective Disorder
  Interventions:   Drug: Bazedoxifene Acetate;   Drug: Placebo
  Sponsors:   The Alfred;   Monash University;   Monash Health
  Not yet recruiting
• Compassion Meditation for Older Adults

  NCT03964246

  Condition:   Anxiety and Mood Disorders
  Interventions:   Behavioral: Compassion Meditation (CM) intervention;   Other: Heathy Aging Psychoeducation
  Sponsor:   VA Office of Research and Development
  Recruiting
• PrEP and Consumptions

  NCT03449771

  Conditions:   Psychoactive Substance Use;   Mood Disorders
  Intervention:   Other: self-administered questionnaire
  Sponsor:   University Hospital, Montpellier
  Recruiting
• Targeting Auditory Hallucinations With Alternating Current Stimulation

  NCT03221270

  Conditions:   Schizophrenia;   Schizo Affective Disorder
  Interventions:   Device: tACS (alpha);   Device: Sham tACS (alpha)
  Sponsors:   University of North Carolina, Chapel Hill;   National Institute of Mental Health (NIMH)
  Recruiting
• Brain Emotion Circuitry-Targeted Self-Monitoring and Regulation Therapy (BE-SMART)

  NCT03183388

  Condition:   Mood Disorders
  Intervention:   Behavioral: BE-SMART
  Sponsors:   Yale University;   National Institute of Mental Health (NIMH)
  Recruiting
• Evaluation of an App for Smartphones for People With a Bipolar Affective Disorder

  NCT03275714

  Condition:   Bipolar Affective Disorder
  Intervention:   Device: Smartphone APP
  Sponsor:   Medical University of Graz
  Recruiting
• Memantine Effects on Sensorimotor Gating and Neurocognition in Schizophrenia

  NCT03860597

  Conditions:   Schizophrenia;   Schizo Affective Disorder;   Schizoaffective Disorder;   Healthy
  Interventions:   Drug: Memantine;   Drug: Placebos
  Sponsor:   University of California, San Diego
  Recruiting
• Assessment of Cardiac Autonomic Behavior in Patients With Mood Disorders

  NCT01272518

  Conditions:   Mood Disorder;   Mania;   Depression
  Intervention:  
  Sponsor:   Sao Jose do Rio Preto Medical School
  Recruiting
• Hostile Interpretation Bias Training to Treat Irritability

  NCT03592368

  Conditions:   Irritable Mood;   Mood Disorders
  Intervention:   Device: IBT
  Sponsor:   University of Colorado, Denver
  Recruiting
• The Analysis of Physical, Physiological and Behavioral Data Collected From Sensors That Track the Mental Condition of Psychiatric Patients

  NCT03714893

  Condition:   Psychiatric Disorders Mood
  Intervention:   Device: Sensor wrist watch
  Sponsor:   Sheba Medical Center
  Not yet recruiting
• Biological Classification of Mental Disorders

  NCT03984084

  Conditions:   Mental Disorder;   Depressive Disorder;   Anxiety;   Trauma and Stressor Related Disorders
  Intervention:   Other: no intervention
  Sponsor:   Max-Planck-Institute of Psychiatry
  Recruiting
• Studies of Brain Function and Course of Illness in Pediatric Bipolar Disorder

  NCT00025935

  Condition:   Mood Disorder
  Intervention:  
  Sponsor:   National Institute of Mental Health (NIMH)
  Recruiting
• Optimizing Long-Term Outcomes for Winter Depression With CBT-SAD and Light Therapy

  NCT03691792

  Condition:   Seasonal Affective Disorder
  Interventions:   Behavioral: Cognitive-Behavioral Therapy (CBT-SAD);   Other: Light Therapy
  Sponsors:   University of Vermont;   Teodor Postolache;   Kathryn Roecklein;   Peter Franzen;   Greg Siegle;   David Kolko;   Pamela Vacek
  Recruiting
• Pilot Study of Neuromodulation for Enhancement of Emotion Regulation in Bipolar Mood Disorders

  NCT03622749

  Conditions:   Bipolar Disorder;   Transcranial Magnetic Stimulation
  Intervention:   Device: Transcranial Magnetic Stimulation (TMS)
  Sponsors:   Massachusetts General Hospital;   National Institute of Neurological Disorders and Stroke (NINDS)
  Not yet recruiting
• Racing and Crowded Thoughts in Mood Disorders

  NCT02036606

  Condition:   Bipolar Disorder
  Intervention:   Behavioral: questionary
  Sponsor:   University Hospital, Strasbourg, France
  Recruiting
• Study of Sensorimotor Compatibility Effects in Bipolar Affective Disorder.

  NCT03249857

  Condition:   Bipolar Affective Disorder
  Interventions:   Behavioral: cognitive tasks + IQ + MINI;   Behavioral: cognitive tasks
  Sponsor:   Centre Hospitalier Universitaire de Saint Etienne
  Recruiting
• Family Study of Affective and Anxiety Spectrum Disorders

  NCT00071786

  Conditions:   Mood Disorders;   Anxiety Disorders
  Intervention:  
  Sponsor:   National Institute of Mental Health (NIMH)
  Recruiting
• Telemetry-Triggered Educational Content Delivery Using MyChart in Mood Disorders

  NCT03575728

  Conditions:   Bipolar Disorder;   Mood Disorders
  Intervention:   Other: MyChart-MHT
  Sponsor:   Sunnybrook Health Sciences Centre
  Recruiting
• Design and Methods of the Mood Disorder Cohort Research Consortium (MDCRC) Study

  NCT03088657

  Conditions:   Mood Disorders;   Bipolar Disorder;   Major Depressive Disorder
  Intervention:  
  Sponsors:   Korea University Anam Hospital;   Ministry of Health & Welfare, Korea;   Seoul National University Hospital;   Severance Hospital;   Seoul National University Bundang Hospital;   Samsung Medical Center;   Gyeongsang National University Hospital;   Pusan National University Hospital;   Chonnam National University Hospital;   National Center for Mental Health, Korea
  Recruiting
• Financial Incentives to Improve Medication Adherence

  NCT04191876

  Conditions:   Schizophrenia;   Schizo Affective Disorder;   Bipolar Disorder;   Depression
  Intervention:   Other: Wellth - Financial Incentives
  Sponsor:   Northwell Health
  Recruiting
• Research of Unified Protocol for the Treatment of Common Mental Disorders in Adolescents in Hong Kong

  NCT04091139

  Conditions:   Depressive Disorder;   Anxiety Disorders
  Interventions:   Behavioral: Unified protocol for adolescents (UP-A);   Behavioral: Treatment as usual (TAU)
  Sponsors:   Chinese University of Hong Kong;   Castle Peak Hospital
  Recruiting
• A Clinical Trial Via Telepsychiatry of Treatments for the Management of Emotional Dysregulation in Youth

  NCT03911414

  Conditions:   Mood Disturbance;   Mood Disorders;   Natural Supplements;   Alternative Treatment
  Interventions:   Drug: Open-label Treatment with Omega-3 Fatty Acids + Inositol;   Drug: Open-label Treatment with N-acetylcysteine
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Outpatient Nurse Monitoring Under the Prevention of Recurrent Suicidal

  NCT02721316

  Conditions:   Mood Disorder;   Reactive Depression
  Intervention:   Other: Supported with intensive nursing follow post hospitalization
  Sponsor:   University Hospital, Montpellier
  Not yet recruiting
• Validation of the Ontological Addiction Scale

  NCT04137471

  Conditions:   Mood Disorders;   Emotional Disorder
  Intervention:  
  Sponsor:   University Hospital, Montpellier
  Recruiting
• A Pilot Study of Prophylactic Management of Lamotrigine in Pregnant Women

  NCT03774641

  Conditions:   Bipolar Disorder;   Major Depressive Disorder;   Schizo Affective Disorder
  Intervention:   Drug: Lamictal
  Sponsor:   Johns Hopkins University
  Recruiting
• Effect of Systemic Inflammation on Emotion and Cognition in Patients With Mood Disorder - A Vaccine Study

  NCT03523767

  Condition:   Major Depressive Disorder
  Interventions:   Biological: S.typhi Injection;   Biological: Normal Saline Injection
  Sponsor:   The University of Texas Health Science Center, Houston
  Recruiting
• Anti-stigma Intervention for Chinese American Older Adults

  NCT03820297

  Conditions:   Mood Disorders;   Anxiety Disorders
  Intervention:   Behavioral: 10 sessions of ASGI
  Sponsors:   NYU Langone Health;   Substance Abuse and Mental Health Services Administration (SAMHSA)
  Not yet recruiting
• Doing More With Less": Optimizing Psychotherapeutic Services in the Mental Health System

  NCT03608449

  Conditions:   Anxiety Disorder;   Affective Disorders;   Personality Disorders
  Intervention:   Other: questionnaires
  Sponsor:   Shalvata Mental Health Center
  Not yet recruiting
• Digital Training for Non-Specialist Health Workers to Deliver a Brief Psychological Treatment for Depression

  NCT04157816

  Conditions:   Depression;   Mental Disorder;   Psychological
  Interventions:   Other: Face-to-Face Training;   Other: Digital Training;   Other: Coaching Support
  Sponsors:   Harvard Medical School;   Sangath
  Not yet recruiting
• Oxytocin on Irritability/Emotional Dysregulation of Disruptive Behavior and Mood Disorders

  NCT02824627

  Conditions:   Mood Disorder;   Disruptive Behavior Disorders
  Interventions:   Drug: Oxytocin;   Drug: Placebo
  Sponsor:   University of Nebraska
  Recruiting
• Multimodal Imaging of ECT Effects

  NCT02871141

  Condition:   Major Depressive Disorder
  Interventions:   Procedure: electroconvulsive therapy;   Drug: Antidepressant
  Sponsor:   Charite University, Berlin, Germany
  Recruiting
• Promoting Widowed Elders Lifestyle After Loss

  NCT02631291

  Conditions:   Mood Disorders;   Depression;   Anxiety;   Grief;   Bereavement;   Health Behavior
  Interventions:   Behavioral: Behavioral self-monitoring;   Behavioral: Behavioral self-monitoring + Motivational interviewing
  Sponsor:   University of Pittsburgh
  Recruiting
• Thoughts and Health - Preventing Depression in Adolescents

  NCT04128644

  Conditions:   Depression;   Adolescent Development;   Mental Disorder, Child
  Interventions:   Behavioral: Thoughts & health;   Other: Treatment as Usual
  Sponsor:   Vastra Gotaland Region
  Not yet recruiting
• Technology Enhanced Family Treatment

  NCT03913013

  Conditions:   Mood Disorders;   Bipolar Disorder;   Major Depression
  Intervention:   Behavioral: Family-Focused Treatment with MCC App
  Sponsors:   University of California, Los Angeles;   National Institute of Mental Health (NIMH)
  Recruiting
• Prevalence of Mood Disorders and Mental Health Service Use Among Immigrants in Santiago, Chile

  NCT04114565

  Condition:   Major Depressive Disorder
  Intervention:  
  Sponsors:   Pontificia Universidad Catolica de Chile;   Fondo Nacional de Desarrollo Científico y Tecnológico, Chile
  Recruiting
• Quantitative Investigation of Environment and Participation

  NCT04106960

  Conditions:   Supported Accommodation Residents;   Schizophrenia, Shizotypal and Delusional Disorders;   Mood Affective Disorders;   Disorders of Adult Personality and Behavior
  Intervention:   Other: No Intevention Used
  Sponsors:   Queen Margaret University;   NHS Lothian
  Not yet recruiting
• The Psychobiology of Childhood Temperament

  NCT00060775

  Conditions:   Mood Disorders;   Anxiety Disorders;   Adolescents
  Intervention:  
  Sponsor:   National Institute of Mental Health (NIMH)
  Recruiting
• A Study on Better Cognitive Functioning Through Braintraining on the Internet

  NCT04006756

  Conditions:   Depression;   Late Life Mood Disorder;   Impaired Cognition;   Alteration in Mood;   Alteration in Cognition
  Interventions:   Behavioral: Online cognitive training 1;   Behavioral: Online cognitive training 2
  Sponsor:   VU University Medical Center
  Not yet recruiting
• Imaging SV2A in Mood Disorders

  NCT02734602

  Conditions:   Major Depressive Disorder;   Post-Traumatic Stress Disorder
  Interventions:   Drug: Ketamine;   Behavioral: Cognitive Testing;   Radiation: PET;   Device: MRI
  Sponsors:   Yale University;   VA Office of Research and Development
  Recruiting
• Effectiveness of the First French Psychoeducational Program on Unipolar Depression

  NCT02501226

  Conditions:   Unipolar Depressed Outpatients;   Mild Severity;   Without Psychotic Features
  Interventions:   Other: Treatment as usual;   Behavioral: ENVIE psychoeducational program
  Sponsors:   University Hospital, Montpellier;   Groupe Hospitalier de la Rochelle Ré Aunis;   Centre Hospitalier Universitaire de Besancon;   Centre Hospitalier Béziers;   University Hospital, Clermont-Ferrand;   Centre Hospitalier Universitaire de Nice;   Centre Hospitalier de l'Agglomération de Nevers;   Centre Psychothérapique de Nancy;   Hôpitaux à Bron;   Assistance Publique - Hôpitaux de Paris;   Centre Hospitalier Esquirol
  Recruiting
• Reducing the Rate and Duration of Re-ADMISsions Among Patients With Unipolar Disorder and Bipolar Disorder Using Smartphone-based Monitoring and Treatment - The RADMIS Trials

  NCT03033420

  Conditions:   Affective Disorders;   Unipolar Depression;   Bipolar Disorder
  Intervention:   Device: A smartphone-based monitoring system including a) an integrated feedback loop between patients and clinicians and b) context-aware CBT modules
  Sponsors:   Psychiatric Centre Rigshospitalet;   Technical University of Denmark
  Recruiting
• Effect of Behavioral Intervention on Cannabinoid Receptors in BAD

  NCT04168697

  Conditions:   Bipolar Affective Disorder, Currently in Remission;   Bipolar Disorder I;   Bipolar Disorder II
  Intervention:   Behavioral: Wim Hof method
  Sponsor:   Wayne State University
  Not yet recruiting
• DIMES - DIgital MEdicine Study for Adults With Schizophrenia, Bipolar I Disorder, or Major Depression Currently Using Aripiprazole

  NCT03881449

  Conditions:   Schizophrenia;   Major Depressive Disorder;   Bi-Polar Disorder;   Schizo Affective Disorder
  Intervention:   Combination Product: ABILIFY MYCITE
  Sponsors:   Durham VA Medical Center;   Otsuka Pharmaceutical Development and Commercialization, Inc.
  Recruiting
• EnBrace HR for PMS With Prominent Mood Symptoms or Menstrual Related Mood Disorders

  NCT04123483

  Conditions:   Premenstrual Syndrome;   Premenstrual Dysphoric Disorder;   Premenstrual Tension;   Menstrual Related Mood Disorder
  Intervention:   Drug: EnBrace HR Softgel
  Sponsors:   Massachusetts General Hospital;   JayMac Pharmaceuticals, LLC
  Not yet recruiting
• Targeting Adolescent Depressive Symptoms Via Brief, Web-Based Interventions

  NCT04066985

  Conditions:   Depression;   Depressive Disorder;   Behavioral Symptoms;   Mood Disorders;   Mental Disorders
  Interventions:   Behavioral: Growth Mindset Online Single-Session Program;   Behavioral: Self-Kindness Online Single-Session Program;   Behavioral: Supportive Therapy Online Single-Session Program (Control)
  Sponsors:   Child Mind Institute;   Stony Brook University
  Recruiting
• Effects of Behavioural Activation on Emotional Cognition and Mood

  NCT03995186

  Conditions:   Depression;   Depressive Disorder;   Mood Disorders;   Cognition
  Interventions:   Behavioral: Behavioural activation;   Behavioral: Activity monitoring
  Sponsor:   University of Oxford
  Recruiting
• Electronic Communication Augmented Mental Health Care

  NCT03925038

  Conditions:   Depressive Disorder;   Anxiety Disorders;   Bipolar Affective Disorder
  Interventions:   Behavioral: Augmented Care: Electronic media dashboard;   Behavioral: Treatment as Usual
  Sponsors:   Johns Hopkins University;   Once Upon a Time Foundation
  Recruiting
• Mechanisms of Rumination Change in Adolescent Depression

  NCT03859297

  Conditions:   Major Depressive Disorder;   Mood Disorders
  Interventions:   Behavioral: Rumination-Focused CBT;   Behavioral: Relaxation-based Therapy
  Sponsors:   University of Utah;   University of Exeter;   National Institute of Mental Health (NIMH)
  Recruiting
• Effects of Seven Day Prucalopride Administration in Healthy Volunteers

  NCT03572790

  Conditions:   Molecular Mechanisms of Pharmacological Action;   Depression;   Depressive Disorder;   Mood Disorders;   Mental Disorders;   Antidepressive Agents;   Cognition
  Interventions:   Drug: Prucalopride;   Other: Placebo
  Sponsor:   University of Oxford
  Recruiting
• Ketamine for Mood Disorders With Suicidal Ideation

  NCT04099771

  Conditions:   Depressive Disorder, Major;   Suicidal Ideation
  Intervention:   Drug: Ketamine
  Sponsor:   The Miriam Hospital
  Recruiting
• Citalopram and Stress Reactivity

  NCT04161209

  Conditions:   Depression;   Depressive Disorder;   Mental Disorder;   Antidepressive Agents;   Cognition;   Stress
  Interventions:   Drug: Citalopram;   Other: Placebo
  Sponsors:   University of Oxford;   University of Bath
  Recruiting
• Citalopram and Self Emotional Processing

  NCT04169230

  Conditions:   Molecular Mechanisms of Pharmacological Action;   Depression;   Depressive Disorder;   Mental Disorder;   Antidepressive Agents;   Cognition
  Interventions:   Drug: Citalopram;   Drug: Placebo oral tablet
  Sponsors:   University of Oxford;   University of Bath
  Recruiting
• Reaching and Engaging Depressed Senior Center Clients (REDS)

  NCT03246789

  Conditions:   Depression, Unipolar;   Mental Health Disorder
  Interventions:   Behavioral: Engage-M;   Behavioral: Wellness in Mind and Body
  Sponsors:   Weill Medical College of Cornell University;   New York City Department for the Aging;   National Institute of Mental Health (NIMH)
  Recruiting
• Mindfulness-Based Stress Reduction (MBSR) and Transcranial Direct Current Stimulation (tDCS)

  NCT03680664

  Conditions:   Anxiety Disorders;   Mood Disorders;   Transcranial Direct Current Stimulation;   tDCS;   Stress Reduction
  Interventions:   Device: Active tDCS;   Other: sham tDCS;   Behavioral: MBSR
  Sponsors:   Centre for Addiction and Mental Health;   University of Toronto
  Recruiting
• An Investigation of the Relationship Between Omega-3 Fatty Acid Nutrition and Mental Health in Children and Adolescents

  NCT04158869

  Conditions:   Major Depressive Disorder;   Depression;   Child Mental Disorder
  Intervention:  
  Sponsors:   Swiss Federal Institute of Technology;   Psychiatric University Hospital, Zurich
  Recruiting
• Cooperation for Primary Care Patients on Sick Leave for CMD: Care Manager and Workplace Intervention - CO-WORK-CARE

  NCT03250026

  Conditions:   Depressive Disorder;   Anxiety Disorders
  Interventions:   Behavioral: Workplace convergence dialogue;   Behavioral: Care Manager
  Sponsors:   Göteborg University;   Vastra Gotaland Region
  Recruiting
• Assisted Animal Therapy: ReAnimal

  NCT03898843

  Conditions:   Anxiety;   Mood Disorders;   Post Traumatic Stress Disorder
  Interventions:   Other: Animal assisted therapy;   Biological: Nasal swab sampling;   Behavioral: STAI-Y and POMS Questionnaires;   Procedure: physiological parameters measure;   Other: Visual Analog Scale (VAS);   Behavioral: Impact of Event Scale - Revised (IES-R);   Behavioral: satisfaction questionnaire;   Biological: Rectal swab sampling
  Sponsor:   Hospices Civils de Lyon
  Not yet recruiting
• An Eye Tracking Study of Affective Disorder Patients With Suicide Risk

  NCT03711045

  Conditions:   Major Depressive Disorder;   Bipolar Disorder;   Suicide
  Intervention:   Behavioral: eye-tracking
  Sponsor:   Central South University
  Recruiting
• Seasonal Affective Disorder and Visual Impairment

  NCT03403959

  Conditions:   Seasonal Affective Disorder;   Visual Impairment
  Intervention:   Device: light therapy
  Sponsors:   Psychiatric Centre Rigshospitalet;   Glostrup University Hospital, Copenhagen
  Recruiting
• Cannabidiol as an Adjunctive Treatment for Bipolar Depression

  NCT03310593

  Conditions:   Bipolar Disorder;   Bipolar Depression;   Bipolar Affective Disorder
  Interventions:   Drug: Cannabidiol;   Drug: Placebo
  Sponsors:   Hospital de Clinicas de Porto Alegre;   Federal University of Rio Grande do Sul;   University of Sao Paulo
  Recruiting
• Validation of an Automated Online Language Interpreting Tool - Phase Two.

  NCT03538860

  Conditions:   Mood Disorder;   Anxiety Disorder;   Substance Use Disorder;   Chronic Medical Condition
  Interventions:   Behavioral: Active comparator: Human interpreter;   Behavioral: Intervention: Asynchronous Telepsychiatry
  Sponsors:   University of California, Davis;   Agency for Healthcare Research and Quality (AHRQ)
  Recruiting
• Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy

  NCT03591224

  Conditions:   Depression;   Anxiety;   Major Depressive Disorder;   Generalized Anxiety Disorder;   Mood Disorders
  Interventions:   Other: Pharmacogenomic Testing;   Other: Pharmacist Standard of Care
  Sponsors:   John Papastergiou Pharmacy Ltd;   Green Shield Canada
  Recruiting
• Technology Enhanced Behavioral Activation Treatment for Substance Use

  NCT02707887

  Conditions:   Substance-Related Disorders;   Depressive Disorder;   Behavioral Symptoms;   Risk-Taking;   Sexual Behavior
  Interventions:   Behavioral: LETS ACT;   Behavioral: LETS ACT-SE;   Behavioral: Treatment as Usual
  Sponsors:   University of North Carolina, Chapel Hill;   National Institute on Drug Abuse (NIDA)
  Recruiting
• The Police-Mental Health Linkage System

  NCT03740139

  Conditions:   Mental Disorders, Severe;   Schizophrenia and Related Disorders;   Bipolar Disorder;   Depressive Disorder
  Intervention:   Other: The Police-Mental Health Linkage System
  Sponsors:   New York State Psychiatric Institute;   National Institute of Mental Health (NIMH)
  Recruiting
• Correlation Study Between Mental Behavioral Symptoms in Dementia Patients and Mood Disorders of Caregivers

  NCT03724344

  Condition:   Dementia
  Intervention:   Other: Cross section resaerch
  Sponsor:   Shanghai Mental Health Center
  Recruiting
• Proactive, Personalized Postpartum Mental Healthcare

  NCT03803189

  Conditions:   Postpartum Depression;   Postpartum Blues;   Postpartum Anxiety;   Postpartum Mood Disorder
  Intervention:   Behavioral: Usual care plus eToolkit
  Sponsors:   Women's College Hospital;   Canadian Institutes of Health Research (CIHR);   North York General Hospital;   Michael Garron Hospital
  Recruiting
• Treatment With Quetiapine for Youth With Substance Use Disorders and Severe Mood Dysregulation

  NCT02845453

  Conditions:   Substance Use Disorders;   Bipolar Disorder;   Mood Disorders
  Interventions:   Drug: Quetiapine;   Drug: Placebo
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers

  NCT00024635

  Conditions:   Mood Disorder;   Anxiety Disorder;   Healthly Volunteers;   Bipolar Disorders;   Depression
  Intervention:  
  Sponsors:   National Institute of Mental Health (NIMH);   Suburban Hospital
  Recruiting
• Keeping Well:Online Cognitive Behavioral Therapy (CBT) for Pregnant Women With Depressive Symptoms

  NCT01909167

  Conditions:   Anxiety;   Mental Disorders;   Postpartum Depression;   Depressive Symptoms
  Interventions:   Behavioral: Online Cognitive Behavioral Therapy (CBT);   Other: Treatment as usual
  Sponsor:   Imperial College London
  Not yet recruiting
• A Personalized Approach to Effects of Affective Bias Modification on Symptom Change and Rumination

  NCT04137367

  Condition:   Major Depressive Disorder
  Interventions:   Behavioral: Affective bias modification;   Behavioral: Sham Affective bias modification
  Sponsors:   University of Oslo;   Extrastiftelsen;   Diakonhjemmet Hospital;   University of Oxford
  Recruiting
• Resilience in Adolescent Development

  NCT03458936

  Conditions:   Risk Assessment;   Resilience, Psychological;   Depression;   Mood Disorders;   Anxiety Disorders
  Intervention:  
  Sponsor:   University of Texas Southwestern Medical Center
  Recruiting
• Study of Premenstrual Syndrome and Premenstrual Dysphoria

  NCT00001177

  Conditions:   PMS;   Premenstrual Mood Disorder;   PMDD;   Depression
  Intervention:  
  Sponsor:   National Institute of Mental Health (NIMH)
  Recruiting
• Continuous Theta Burst Stimulation as an add-on Treatment for Bipolar Depression

  NCT03603561

  Conditions:   Bipolar Disorder;   Bipolar Depression;   Bipolar I Disorder;   Bipolar II Disorder;   Depression;   Mood Disorders;   Mental Disorder
  Interventions:   Device: cTBS;   Device: Sham cTBS
  Sponsors:   Universiteit Antwerpen;   Universitair Ziekenhuis Brussel
  Recruiting
• e-Mindfulness for Depression

  NCT03922217

  Conditions:   Depression;   Mental Health Disorder
  Intervention:   Device: Mindful My Way
  Sponsor:   Washington University School of Medicine
  Recruiting
• A Family Depression Prevention Program

  NCT02021578

  Condition:   Depression
  Interventions:   Behavioral: Family Cognitive Behavioral Prevention;   Behavioral: Written information
  Sponsors:   Vanderbilt University;   San Diego State University
  Recruiting
• Mobile Virtual Positive Experiences for Anhedonia

  NCT03715400

  Conditions:   Anhedonia;   Virtual Reality;   Depression;   Mood Disorders
  Intervention:   Behavioral: Positive Virtual Reality Training
  Sponsor:   University of California, Los Angeles
  Recruiting
• Mood Disorders Bladder Cancer

  NCT04036877

  Condition:   Bladder Cancer
  Intervention:   Other: Mood Disorder Assessment
  Sponsor:   University of Kansas Medical Center
  Recruiting
• Heart Rate Variability as a Clinical Marker in a Population of Anxio-depressive Patients

  NCT04192669

  Condition:   Anxio Depressive Disorder
  Intervention:   Device: Heart rate monitoring
  Sponsor:   Tatiana Besse-Hammer
  Recruiting
• A Clinical Trial of Fluvoxamine for Melancholia

  NCT04160377

  Conditions:   Depressive Disorder;   Endogenous Depression;   Melancholia
  Intervention:   Drug: Fluvoxamine
  Sponsor:   Lingjiang Li
  Recruiting
• A Study to Evaluate the Benefit of Opti-Me Application to Different Treatments of MDD

  NCT04148612

  Condition:   Depressive Disorder, Major
  Intervention:   Diagnostic Test: Opti-Me
  Sponsor:   ElMindA Ltd
  Not yet recruiting
• Appalachian Mind Health Initiative

  NCT04120285

  Condition:   Major Depressive Disorder
  Intervention:   Behavioral: remote internet-based cognitive behavior therapy (eCBT)
  Sponsors:   West Virginia University;   Patient-Centered Outcomes Research Institute
  Not yet recruiting
• Role Of Ketamine in Treatment-Resistant Major Depressive Disorder And Its Effect on Suicidality

  NCT04101474

  Condition:   Treatment Resistant Depression
  Intervention:   Drug: Ketamine
  Sponsor:   Assiut University
  Not yet recruiting
• Ketamine for Treatment Resistant MDD

  NCT04021433

  Condition:   Depressive Disorder, Major
  Intervention:   Drug: Ketamine
  Sponsor:   Hadassah Medical Organization
  Recruiting
• Cerebellar Stroke and Mood Disorders

  NCT03515486

  Condition:   Stroke
  Intervention:   Other: Post stroke mood disorders evaluation
  Sponsor:   University Hospital, Bordeaux
  Recruiting
• Mini Theta Burst TMS in MDD Patients

  NCT04014959

  Condition:   Major Depressive Disorder
  Intervention:   Combination Product: TMS/ fMRI Stimulation
  Sponsor:   University of Pennsylvania
  Recruiting
• The Role of HNKs in the Antidepressant Effect of Ketamine

  NCT03977675

  Condition:   Major Depressive Disorder
  Intervention:   Drug: Ketamine
  Sponsor:   Columbia University
  Recruiting
• Gut Feeling: Understanding the Mechanisms Underlying the Antidepressant Properties of Probiotics

  NCT03893162

  Condition:   Major Depressive Disorder
  Interventions:   Dietary Supplement: Multi-strain probiotic;   Other: Placebo
  Sponsor:   King's College London
  Recruiting
• Scopolamine in Healthy Volunteers

  NCT03874130

  Condition:   Major Depressive Disorder (MDD)
  Intervention:   Drug: Scopolamine
  Sponsor:   Repurposed Therapeutics, Inc.
  Recruiting
• Improving Brain Stimulation Through Imaging

  NCT03851380

  Conditions:   Depression;   Depressive Disorder, Treatment-Resistant
  Interventions:   Behavioral: Psychological / Functional Assessment;   Other: Structural and Functional MRI;   Device: Transcranial Magnetic Brain Stimulation and MR Image Guidance
  Sponsors:   VA Office of Research and Development;   Providence VA Medical Center;   Atlanta VA Medical Center
  Recruiting
• ROOM-LIGHT: Effect of a Dynamic Lighting System in Depressed Inpatients

  NCT03821506

  Condition:   Major Depressive Disorder
  Interventions:   Device: Dynamic Light;   Device: Usual care
  Sponsors:   Mental Health Centre Copenhagen;   Mental Health Services in the Capital Region, Denmark;   Toyota-Fonden;   Grosserer L. F. Foghts Fond Denmark;   ELFORSK Danish Energy;   Technical University of Denmark
  Recruiting
• Contact: Developing New Clinical Management Strategies

  NCT03812588

  Condition:   Major Depressive Disorder
  Interventions:   Drug: Escitalopram;   Drug: Placebo
  Sponsors:   New York State Psychiatric Institute;   University of Haifa
  Recruiting
• The Role of Sex Steroids and Serotonin Brain Dynamics in Perinatal Mental Health

  NCT03795688

  Conditions:   Major Depressive Disorder;   Perinatal Depression
  Intervention:   Other: Pregnancy
  Sponsors:   Vibe G Frøkjær, MD, PhD;   Center for Integrated Molecular Brain Imaging, Copenhagen, Denmak;   Mental Health Centre Copenhagen;   University of Copenhagen
  Recruiting
• Vortioxetine in the Elderly vs. Selective Serotonin Reuptake Inhibitors (SSRIs): a Pragmatic Assessment

  NCT03779789

  Condition:   Major Depressive Disorder
  Interventions:   Drug: Vortioxetine;   Drug: Sertraline;   Drug: citalopram;   Drug: Escitalopram;   Drug: Paroxetine;   Drug: Fluoxetine;   Drug: Fluvoxamine
  Sponsors:   Azienda Ospedaliera Universitaria Integrata Verona;   University of Catania
  Not yet recruiting
• Effect of Vitamin D Administration Along With SSRIs in Patients With Major Depressive Disorder

  NCT03754712

  Condition:   MDD
  Intervention:   Dietary Supplement: Vitamin D3
  Sponsor:   Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
  Recruiting
• Efficacy and Safety of Accelerated Transcranial Magnetic Stimulation With H1-coil (dTMS)

  NCT03718013

  Condition:   Major Depressive Disorder
  Interventions:   Device: accelerated deep TMS;   Device: standard deep TMS
  Sponsor:   Sveti Ivan Psychiatric Hospital
  Recruiting
• Clinical, Neurocognitive, and Emotional Effects of Psilocybin in Depressed Patients - Proof of Concept

  NCT03715127

  Condition:   Depressive Disorder, Major
  Interventions:   Drug: Psilocybine oral capsule;   Drug: Placebo oral capsule
  Sponsors:   University of Zurich;   Schweizerischer Nationalfonds
  Recruiting
• Maintenance of Response After rTMS for Depression Using tDCS

  NCT03708159

  Condition:   Major Depressive Disorder
  Interventions:   Device: active tDCS + mindfulness meditation;   Other: sham tDCS + mindfulness meditation
  Sponsors:   Centre for Addiction and Mental Health;   University Health Network, Toronto
  Recruiting
• Ketamine Co-induction for Patients With Major Depressive Disorder

  NCT03666494

  Conditions:   Ketamine;   Depression;   Anesthesia
  Interventions:   Drug: Ketamine Hydrochloride;   Drug: Propofol;   Drug: Fentanyl
  Sponsor:   University of Saskatchewan
  Not yet recruiting
• Transcranial Magnetic Stimulation Study of Cortical Excitability as Marker of Antidepressant Response: EXCIPSY Study

  NCT03606850

  Condition:   Major Depressive Disorder
  Intervention:   Device: Measurements of markers of cortical excitability by TMS
  Sponsors:   Centre Hospitalier du Rouvray;   Centre hospitalier de Ville-Evrard, France;   University Hospital Caen, France
  Recruiting
• Modeling Multi-level Dyadic Behavior to Transform the Science and Practice of Psychotherapy Process and Outcome.

  NCT03594773

  Condition:   Major Depressive Disorder
  Interventions:   Behavioral: Cognitive Behavioral Therapy;   Behavioral: Interpersonal Psychotherapy
  Sponsors:   University of Pittsburgh;   Carnegie Mellon University
  Recruiting
• Pharmacogenetics Informed Tricyclic Antidepressant Dosing (PITA)

  NCT03548675

  Condition:   Depressive Disorder, Major
  Intervention:   Drug: TCA treatment
  Sponsors:   Radboud University;   ZonMw: The Netherlands Organisation for Health Research and Development
  Recruiting
• tDCS as add-on Treatment to Cognitive-Behavior Therapy in People With MDD

  NCT03548545

  Conditions:   Major Depressive Disorder;   CBT;   Transcranial Direct Current Stimulation
  Intervention:   Device: tDCS
  Sponsors:   University of Minho;   Fundação para a Ciência e a Tecnologia
  Recruiting
• Switching From SSRI to Desvenlafaxine on Cognitive Functioning

  NCT03432221

  Condition:   Major Depressive Disorder
  Intervention:   Drug: Desvenlafaxine
  Sponsors:   Corporacion Parc Tauli;   Pfizer
  Recruiting
• Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response

  NCT03367533

  Condition:   Depressive Disorder, Major
  Interventions:   Drug: Ketamine;   Drug: Perampanel;   Drug: Placebo
  Sponsor:   Yale University
  Recruiting
• McLean and Genomind Prospective Study

  NCT03113890

  Conditions:   Major Depressive Disorder;   PTSD
  Interventions:   Genetic: Phlebotomy - Folate;   Genetic: Cheek Swab;   Other: Self-report surveys
  Sponsors:   Mclean Hospital;   Genomind, LLC
  Recruiting
• Rapid Antidepressant Effects of Leucine

  NCT03079297

  Condition:   Major Depressive Disorder
  Interventions:   Drug: L-Leucine;   Other: Maltodextrin
  Sponsor:   University of Texas Southwestern Medical Center
  Recruiting
• Neurobiology of Treatment Responses in MDD

  NCT03068247

  Condition:   Major Depressive Disorder
  Interventions:   Drug: Duloxetine;   Drug: Placebo
  Sponsor:   University of Utah
  Not yet recruiting
• Comparative Effectiveness Research Trial for Antidepressant Incomplete and Non-responders With TRD

  NCT02977299

  Condition:   Treatment Resistant Major Depressive Disorder
  Interventions:   Drug: Aripiprazole;   Device: Repetitive transcranial magnetic stimulation (rTMS);   Drug: Venlafaxine XR
  Sponsors:   Massachusetts General Hospital;   Patient-Centered Outcomes Research Institute
  Recruiting
• Personalized rTMS for Resistant Depression

  NCT02863380

  Conditions:   Depressive Disorder;   Treatment-Resistant
  Interventions:   Procedure: Functional magnetic resonance imaging used to individualize rTMS protocol;   Device: Individualized rTMS (transcranial magnetic stimulation);   Device: Classical rTMS (transcranial magnetic stimulation);   Device: Classical tDCS (transcranial direct current stimulation)
  Sponsor:   University Hospital, Strasbourg, France
  Recruiting
• Loneliness and Occurrence of Suicide Attemps and Suicidal Ideas

  NCT02829671

  Condition:   Major Depressive Disorders
  Intervention:   Other: Clinical and biological assessment
  Sponsor:   University Hospital, Montpellier
  Not yet recruiting
• Neuropsychological Factors Associated With Vulnerability to Suicidal Behavior in Depressed Elderly Patients

  NCT02737540

  Condition:   Depressive Disorder, Major
  Intervention:  
  Sponsor:   Centre Hospitalier Universitaire de Nīmes
  Recruiting
• Supportive and Supportive-Expressive Treatment for Depression

  NCT02728557

  Condition:   Major Depressive Disorder
  Interventions:   Behavioral: Supportive-Expressive Therapy;   Behavioral: Supportive Therapy
  Sponsor:   University of Haifa
  Recruiting
• Disorder-tailored Transcranial Direct Current Stimulation (tDCS) of the Prefrontal Cortex

  NCT02715128

  Condition:   Major Depressive Disorder
  Intervention:   Device: Transcranial direct current stimulation (tDCS)
  Sponsor:   Ludwig-Maximilians - University of Munich
  Not yet recruiting
• Study of Neural Responses Induced by Antidepressant Effects

  NCT02674529

  Condition:   Major Depressive Disorder
  Interventions:   Drug: Escitalopram;   Drug: Placebo
  Sponsor:   University of Pittsburgh
  Recruiting
• Intra-nasal vs. Intra-venous Ketamine Administration

  NCT02644629

  Condition:   Major Depressive Disorder
  Interventions:   Drug: Placebo;   Drug: Ketamine (1st phase);   Drug: Ketamine (2st phase)
  Sponsor:   Shalvata Mental Health Center
  Recruiting
• MetAbolism vaRiability of VEnLafaxine

  NCT02590185

  Condition:   Major Depressive Disorders
  Intervention:   Drug: cocktail probe drugs
  Sponsor:   Assistance Publique - Hôpitaux de Paris
  Recruiting
• miRNAs, Suicide, and Ketamine - Plasma Exosomal microRNAs as Novel Biomarkers for Suicidality and Treatment Outcome

  NCT02418195

  Condition:   Major Depressive Disorder
  Intervention:   Drug: ketamine
  Sponsors:   University of Alabama at Birmingham;   National Institute of Mental Health (NIMH)
  Recruiting
• Connectivity Affecting the Antidepressant REsponse Study

  NCT02332291

  Condition:   Major Depressive Disorder
  Interventions:   Drug: Escitalopram;   Drug: Bupropion XL
  Sponsor:   Vanderbilt University Medical Center
  Recruiting
• A Study of Aerobic Exercise for Patients With Bipolar Disorder

  NCT03353337

  Conditions:   Bipolar Disorder;   Cognitive Symptom
  Interventions:   Behavioral: aerobic exercise;   Behavioral: Placebo controlled group
  Sponsor:   Guangzhou Psychiatric Hospital
  Not yet recruiting
• Treating Depression on a Day-to-day Basis: Development of a Tool for Physicians Based on a Smartphone Application

  NCT03678194

  Conditions:   Depression;   Psychiatric Disorder;   Brain Diseases;   Central Nervous System Diseases;   Nervous System Diseases
  Intervention:   Device: Smartphone Support System
  Sponsor:   Centre Hospitalier Charles Perrens, Bordeaux
  Not yet recruiting
• Effects of a Tissue Selective Estrogen Complex (TSEC) on Depression and the Neural Reward System in the Perimenopause"

  NCT03740009

  Conditions:   Perimenopausal Disorder;   Depression
  Intervention:   Drug: Bazedoxifene/Conjugated Estrogen
  Sponsors:   University of North Carolina, Chapel Hill;   Foundation of Hope, North Carolina
  Recruiting
• SMART-DAPPER: Leveraging the Depression And Primary-care Partnership for Effectiveness-implementation Research Project

  NCT03466346

  Conditions:   Depression, Unipolar;   Posttraumatic Stress Disorder;   Trauma
  Interventions:   Drug: Fluoxetine;   Behavioral: Interpersonal Psychotherapy
  Sponsors:   University of California, San Francisco;   University of Nairobi;   National Institute of Mental Health (NIMH);   Kenya Medical Research Institute;   University of California, San Diego;   Makerere University
  Not yet recruiting
• Lipopolysaccharide (LPS) Challenge in Depression

  NCT03142919

  Condition:   Major Depressive Disorder
  Interventions:   Biological: Lipopolysaccharide;   Biological: Placebo
  Sponsor:   Laureate Institute for Brain Research, Inc.
  Recruiting
• Characterization and Treatment of Adolescent Depression

  NCT03388606

  Condition:   Depression
  Intervention:  
  Sponsor:   National Institute of Mental Health (NIMH)
  Recruiting
• Step Away From Depression - Evaluation of a Pedometer Intervention With Inpatients With Major Depression

  NCT02850341

  Condition:   Depression
  Intervention:   Device: Pedometer
  Sponsor:   Charite University, Berlin, Germany
  Recruiting
• The Unified Protocol for the Treatment of Emotional Disorders in Spanish Public Mental Health System

  NCT03064477

  Conditions:   Emotional Disorder;   Anxiety Disorders;   Depressive Disorder
  Interventions:   Behavioral: Unified Protocol;   Behavioral: Cognitive Behavioral Therapy (TAU)
  Sponsors:   Universitat Jaume I;   Universidad de Zaragoza
  Recruiting
• Reward Function and Therapy for Late-Life Depression

  NCT03688139

  Condition:   Major Depressive Disorder
  Interventions:   Behavioral: Engage Therapy;   Behavioral: Supportive Therapy
  Sponsors:   Weill Medical College of Cornell University;   National Institute of Mental Health (NIMH)
  Recruiting
• Promoting Enhanced Pharmacotherapy Choice Through Immunomarkers Evaluation in Depression

  NCT03993457

  Condition:   Depression
  Interventions:   Drug: Escitalopram;   Drug: Bupropion
  Sponsor:   University of Texas Southwestern Medical Center
  Recruiting
• Evaluation of mHealth for Serious Mental Illness

  NCT04068467

  Conditions:   Schizophrenia;   Schizoaffective Disorder;   Bipolar Disorder;   Major Depressive Disorder
  Interventions:   Other: Smartphone App;   Other: Waitlist Control
  Sponsor:   University of Washington
  Not yet recruiting
• Research of Anatomo-functional Biomarkers in Schizophrenia

  NCT03996122

  Condition:   Schizophrenia
  Intervention:   Other: fMRI
  Sponsor:   University Hospital, Caen
  Recruiting
• Effect of 4-session Metacognitive Training in Chinese Adult Outpatients With Schizophrenia Spectrum Disorders and Major Depressive Disorder

  NCT03449394

  Conditions:   Delusions;   Depression
  Intervention:   Other: Metacognitive Training
  Sponsor:   Chinese University of Hong Kong
  Recruiting
• Affective Touching on Poststroke Depression

  NCT03789994

  Condition:   Post-stroke Depression
  Interventions:   Behavioral: Affective touch;   Other: Fine motor exercise
  Sponsors:   Chinese University of Hong Kong;   Research Grants Council
  Not yet recruiting
• Minocycline Hydrochloride in Reducing Chemotherapy Induced Depression and Anxiety in Patients With Stage I-III Breast Cancer

  NCT02203552

  Conditions:   Anxiety Disorder;   Depression;   Recurrent Breast Cancer;   Stage IA Breast Cancer;   Stage IB Breast Cancer;   Stage II Breast Cancer;   Stage IIIA Breast Cancer;   Stage IIIB Breast Cancer;   Stage IIIC Breast Cancer
  Interventions:   Drug: minocycline hydrochloride;   Other: placebo;   Other: laboratory biomarker analysis;   Other: Questionnaire administration
  Sponsor:   Ohio State University Comprehensive Cancer Center
  Recruiting
• Nitrous Oxide for the Treatment of Major Depressive Disorder

  NCT03869736

  Conditions:   Depression;   Major Depressive Disorder
  Interventions:   Drug: Nitrous Oxide;   Drug: Placebo
  Sponsor:   Bayside Health
  Recruiting
• Study of the Synergistic Effects of Biofeedback and Transcranial Electrical Stimulation in Anxio-depressive Disorders

  NCT04189354

  Condition:   Anxio-depressive Disorder
  Intervention:   Device: Transcranial direct current stimulation (t-DCS) device
  Sponsor:   Tatiana Besse-Hammer
  Recruiting
• Post Marketing Study for the Evaluation of Predictix Antidepressant Clinician Software Support Tool in Prescribing Antidepressant Medication/s for the Treatment of Patients Suffering From Major Depressive Disorder

  NCT04138290

  Condition:   Major Depressive Disorder
  Intervention:   Device: Predictix Antidepressant Software tool
  Sponsor:   Taliaz Ltd.
  Not yet recruiting
• The Antidiabetic Metformin as a Novel Adjunct to Antidepressants in Major Depressive Disorder Patients

  NCT04088448

  Condition:   Major Depressive Disorder
  Interventions:   Drug: Placebo oral tablet;   Drug: Metformin
  Sponsor:   Sadat City University
  Recruiting
• Memory Enhancement by Gamma-hydroxybutyrate vs. Trazodone in Major Depressive Disorder.

  NCT04082806

  Condition:   Major Depressive Disorder
  Interventions:   Drug: GHB;   Drug: Trazodone;   Drug: Placebos
  Sponsor:   Erich Seifritz
  Not yet recruiting
• A Study of JNJ-61393215 in the Treatment of Depression

  NCT04080752

  Condition:   Major Depressive Disorder With Anxious Distress
  Interventions:   Drug: JNJ-61393215;   Drug: Placebo
  Sponsor:   Janssen Research & Development, LLC
  Recruiting
• The Phosphodiesterase 3 Inhibitor Cilostazol as an Adjunct to Antidepressants in Major Depressive Disorder Patients

  NCT04069819

  Condition:   Major Depressive Disorder
  Interventions:   Drug: Cilostazol 100 MG Oral Tablet;   Drug: Escitalopram;   Drug: Placebo
  Sponsor:   Sadat City University
  Recruiting
• Controlled Study to Evaluate the Safety and Efficacy of the Predictix Antidepressant Clinician Support Tool

  NCT04031157

  Condition:   Major Depressive Disorder
  Intervention:   Device: Predictix Antidepressant
  Sponsor:   Taliaz Ltd.
  Recruiting
• Efficacy of Eye Movement Desensitization & Reprocessing Versus Cognitive Behavioral Therapy in Post-Traumatic Stress and Depressive Disorders

  NCT04021329

  Condition:   Efficacy of Psychotherapy
  Intervention:   Behavioral: CBT Therapy
  Sponsor:   Khushal Khan Khattak Univeristy, Karak, Pakistan
  Not yet recruiting
• A Study to Evaluate SAGE-217 for Prevention of Relapse in Adult Subjects With Major Depressive Disorder

  NCT04007367

  Condition:   Major Depressive Disorder
  Interventions:   Drug: SAGE-217;   Drug: Placebo
  Sponsor:   Sage Therapeutics
  Recruiting
• Extension Study of Pimavanserin in Subjects With Major Depressive Disorder and Inadequate Response to Antidepressant Treatment

  NCT04000009

  Condition:   Adjunctive Treatment of Major Depressive Disorder
  Intervention:   Drug: Pimavanserin
  Sponsor:   ACADIA Pharmaceuticals Inc.
  Recruiting
• Study to Evaluate the Efficacy and Safety of Adjunctive Pimavanserin in Subjects With Major Depressive Disorder and Inadequate Response to Antidepressant Treatment

  NCT03999918

  Condition:   Adjunctive Treatment of Major Depressive Disorder
  Interventions:   Drug: Pimavanserin;   Drug: Placebo
  Sponsor:   ACADIA Pharmaceuticals Inc.
  Recruiting
• Mechanism of Action of tACS for the Treatment of MDD

  NCT03994081

  Conditions:   Major Depressive Disorder;   MDD
  Interventions:   Device: tACS;   Device: Sham tACS
  Sponsors:   University of North Carolina, Chapel Hill;   Foundation of Hope for Research and Treatment of Mental Illness
  Not yet recruiting
• Study to Evaluate the Efficacy and Safety of Adjunctive Pimavanserin in Subjects With Major Depressive Disorder and Inadequate Response to Antidepressant Treatment (CLARITY-2)

  NCT03968159

  Condition:   Adjunctive Treatment of Major Depressive Disorder
  Interventions:   Drug: Pimavanserin;   Drug: Placebo
  Sponsor:   ACADIA Pharmaceuticals Inc.
  Recruiting
• Adjunctive D-Cycloserine in Major Depressive Disorder

  NCT03937596

  Condition:   Major Depressive Disorder
  Interventions:   Drug: D-cycloserine;   Device: Transcranial Magnetic Stimulator;   Drug: Placebo oral capsule
  Sponsor:   University of Calgary
  Not yet recruiting
• Major Depressive Disorder: Early Prediction of Non-response to Antidepressant Therapy Via a Mobile Digital Scale

  NCT03872492

  Condition:   Depressive Disorder, Major
  Intervention:   Other: Digital Assessment on mobile
  Sponsor:   Ad scientiam
  Recruiting
• A Study of Psilocybin for Major Depressive Disorder (MDD)

  NCT03866174

  Condition:   Depressive Disorder, Major
  Interventions:   Drug: Psilocybin;   Drug: Niacin
  Sponsors:   Usona Institute;   Signant Health;   The Emmes Company, LLC
  Recruiting
• Study With Vortioxetine on Emotional Functioning in Patients With Depression

  NCT03835715

  Condition:   Major Depressive Disorder
  Intervention:   Drug: Vortioxetine
  Sponsor:   H. Lundbeck A/S
  Recruiting
• Waitlist-Control Trial of Smartphone CBT for Major Depressive Disorder (MDD)

  NCT03769350

  Condition:   Major Depressive Disorder
  Intervention:   Device: Smartphone-delivered CBT for MDD
  Sponsors:   Massachusetts General Hospital;   Telefónica S.A.
  Not yet recruiting
• Coaching Intervention in Women At-risk of Depressive Disorders

  NCT03751696

  Condition:   Depressive Disorder
  Interventions:   Behavioral: Group Coaching;   Behavioral: 'General wellbeing' class (GMWP)
  Sponsor:   The University of Hong Kong
  Not yet recruiting
• to Explore the Effective Doses, and to Assess the Safety and Efficacy of Hypidone Hydrochloride Tablets

  NCT03739632

  Condition:   Major Depressive Disorder
  Interventions:   Drug: Hypidone Hydrochloride tablets;   Other: Placebo
  Sponsor:   Shanghai Synergy Pharmaceutical Sciences Co., Ltd.
  Not yet recruiting
• The Object of This Study is to Evaluate the Efficacy, Safety and Tolerability of Cariprazine as an Adjunctive Treatment to Antidepressant Therapy (ADT) in Patients With Major Depressive Disorder (MDD) Who Have Had an Inadequate Response to Antidepressants Alone

  NCT03739203

  Condition:   Major Depressive Disorder
  Interventions:   Drug: Cariprazine;   Drug: Placebo
  Sponsor:   Allergan
  Recruiting
• Efficacy, Safety and Tolerability of Cariprazine as an Adjunctive Treatment to Antidepressant Therapy (ADT) in Patients With Major Depressive Disorder (MDD) Who Have Had an Inadequate Response to Antidepressants Alone

  NCT03738215

  Condition:   Major Depressive Disorder
  Interventions:   Drug: Cariprazine;   Drug: Placebo
  Sponsor:   Allergan
  Recruiting
• A Long-Term Study of Brexpiprazole in Patients With Major Depressive Disorder

  NCT03737474

  Condition:   Major Depressive Disorder
  Intervention:   Drug: Brexpiprazole
  Sponsor:   Otsuka Pharmaceutical Co., Ltd.
  Recruiting
• Group Metacognitive Therapy vs Clinical Management for Depression

  NCT03711123

  Condition:   Major Depressive Disorder
  Interventions:   Behavioral: Group metacognitive therapy;   Behavioral: Clinical management
  Sponsor:   University of Oslo
  Recruiting
• Characterization of Microbial, Immune and Epigenetic Biomarkers for Major Depressive Disorder and ECT Treatment

  NCT03703414

  Condition:   Major Depressive Disorder
  Intervention:   Diagnostic Test: Fecal microbiota composition analysis and blood cytokine level analysis
  Sponsor:   Ziv Hospital
  Not yet recruiting
• A Study of Brexpiprazole in Patients With Major Depressive Disorder

  NCT03697603

  Condition:   Major Depressive Disorder
  Interventions:   Drug: Brexpiprazole;   Drug: Placebo
  Sponsor:   Otsuka Pharmaceutical Co., Ltd.
  Recruiting
• A Multi-component Intervention to Improve Medication Adherence in People With Depressive Disorders

  NCT03668457

  Condition:   Depressive Disorder
  Interventions:   Behavioral: Intervention to Patients;   Behavioral: Intervention to Psychiatrists;   Other: Control
  Sponsors:   Servicio Canario de Salud;   University of La Laguna
  Not yet recruiting
• The Antidepressant Advisor Study

  NCT03628027

  Condition:   Major Depressive Disorder
  Intervention:   Device: Computerised decision support algorithm
  Sponsors:   King's College London;   NHS Lambeth Clinical Commissioning Group;   EMIS PLC;   D'Or Institute for Research and Education
  Recruiting
• Biomarkers of Theta Burst Stimulation in Major Depressive Disorder

  NCT03626181

  Condition:   Depressive Disorder, Treatment-Resistant
  Intervention:   Device: Theta Burst Stimulation ( Transcranial Magnetic Stimulation)
  Sponsor:   University of Calgary
  Recruiting
• Intervention to Prevent Peer Violence & Depressive Symptoms Among At-Risk Adolescents

  NCT03626103

  Conditions:   Depressive Disorder;   Violence
  Interventions:   Behavioral: + Brief ED Intervention (BI);   Behavioral: + Text
  Sponsors:   Rhode Island Hospital;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
  Recruiting
• Olfactory Training and Emotional State

  NCT03605524

  Conditions:   Depressive Symptoms;   Depressive Disorder, Major
  Intervention:   Other: Sensory training
  Sponsor:   University Hospital, Tours
  Recruiting
• Efficacy, Safety, and Tolerability of Levomilnacipran ER in Pediatric (7-17 Years) With Major Depressive Disorder

  NCT03569475

  Condition:   Major Depressive Disorder
  Interventions:   Drug: Levomilnacipran ER;   Drug: Fluoxetine;   Drug: Placebo
  Sponsor:   Allergan
  Recruiting
• A Study to Explore the Efficacy of JNJ-67953964 in the Treatment of Depression

  NCT03559192

  Condition:   Depressive Disorder, Major
  Interventions:   Drug: JNJ-67953964;   Drug: Placebo
  Sponsor:   Janssen Research & Development, LLC
  Recruiting
• The Study of Mindfulness-based Cognitive Therapy and Major Depressive Disorder

  NCT03558256

  Condition:   Major Depressive Disorder
  Interventions:   Behavioral: Mindfulness-based Cognitive Therapy;   Drug: Medication
  Sponsor:   Shanghai Mental Health Center
  Recruiting
• Real-life Effectiveness of Vortioxetine in Depression

  NCT03555136

  Condition:   Major Depressive Disorder
  Intervention:   Drug: Vortioxetine
  Sponsor:   H. Lundbeck A/S
  Recruiting
• Psilocybin - Induced Neuroplasticity in the Treatment of Major Depressive Disorder

  NCT03554174

  Condition:   Major Depressive Disorder
  Interventions:   Drug: Low Dose Psilocybin;   Drug: Placebo;   Drug: Medium Dose Psilocybin
  Sponsors:   Yale University;   Heffter Research Institute
  Recruiting
• A Trial to Evaluate the Efficacy, Safety & Tolerability of Brexpiprazole in the Maintenance Treatment of Adults With Major Depressive Disorder

  NCT03538691

  Condition:   Major Depressive Disorder
  Interventions:   Drug: Brexpiprazole;   Drug: Placebo;   Drug: Citalopram Hydrobromide;   Drug: Escitalopram;   Drug: Fluoxetine;   Drug: Paroxetine;   Drug: Sertraline;   Drug: Duloxetine;   Drug: Venlafaxine Extended Release Oral Capsule
  Sponsor:   Otsuka Pharmaceutical Development & Commercialization, Inc.
  Recruiting
• Cycloserine rTMS Plasticity Augmentation in Depression

  NCT03511599

  Condition:   Major Depressive Disorder
  Interventions:   Drug: Cycloserine;   Device: Transcranial Magnetic Stimulation;   Drug: Placebo Oral Tablet
  Sponsor:   University of Calgary
  Recruiting
• A Study to Evaluate the Efficacy and Safety of MIN-117 in Adult Patients With Major Depressive Disorder

  NCT03446846

  Condition:   Major Depressive Disorder
  Interventions:   Drug: MIN-117 2.5 mg;   Drug: MIN-117 5.0 mg;   Drug: Placebo
  Sponsor:   Minerva Neurosciences
  Recruiting
• Does Nurse Semi Structured Interview Added to a rTMS Improve Patients With Major Depressive Disorder?

  NCT03436823

  Condition:   Depressive Disorder, Major
  Interventions:   Other: nurse semi-structured interview;   Other: Music & Relaxation with eyes closed
  Sponsors:   Rennes University Hospital;   Ministry of Health, France
  Recruiting
• NMDA Modulation in Major Depressive Disorder in Late- Life

  NCT03414931

  Condition:   Depressive Disorder, Major
  Interventions:   Drug: NMDA;   Drug: Sertraline;   Drug: Placebo - Cap
  Sponsor:   Chang Gung Memorial Hospital
  Recruiting
• To Explore the Safety and Efficacy of Hypidone Hydrochloride Tablets in Treatment of Patients With MDD

  NCT03404466

  Condition:   Major Depressive Disorder
  Intervention:   Drug: Hypidone Hydrochloride tablets
  Sponsor:   Shanghai Synergy Pharmaceutical Sciences Co., Ltd.
  Recruiting
• Movement for Depression - An RCT Assessing the Effects of Physical Activity Promotion for People With MDD

  NCT03403881

  Condition:   Major Depressive Disorder
  Interventions:   Behavioral: Physical activity promotion + TAU;   Behavioral: Control
  Sponsor:   Hospital de Clinicas de Porto Alegre
  Recruiting
• A Study of Duloxetine (LY248686) in the Treatment of Japanese Children and Adolescents With Depressive Disorder

  NCT03395353

  Condition:   Depressive Disorder
  Intervention:   Drug: Duloxetine Hydrochloride
  Sponsors:   Eli Lilly and Company;   Shionogi
  Recruiting