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• The Effect of Aspirin on REducing iNflammation in Human in Vivo Model of Acute Lung Injury

  NCT01659307

  Condition:   Acute Lung Injury
  Interventions:   Drug: Aspirin 75mg;   Drug: Lactose powder;   Drug: Aspirin 1200mg
  Sponsors:   Belfast Health and Social Care Trust;   The Intensive Care Society United Kingdom;   Northern Ireland Clinical Trials Unit;   Queen's University, Belfast
  Recruiting
• Macrophage Programing in Acute Lung Injury

  NCT03844893

  Condition:   Acute Respiratory Distress Syndrome
  Intervention:   Procedure: Mini bal
  Sponsor:   National Jewish Health
  Not yet recruiting
• The ASTERS Study: Assessing the Role of Sphingolipids in AcuTE Respiratory Distress Syndrome (ARDS)

  NCT03654352

  Conditions:   Acute Lung Injury;   Acute Respiratory Distress Syndrome
  Intervention:  
  Sponsor:   University of Kentucky
  Recruiting
• The Role of Circulating CircRNAs and MicroRNAs in Acute Lung Injury

  NCT03766204

  Conditions:   Acute Lung Injury;   Acute Respiratory Distress Syndrome
  Intervention:  
  Sponsor:   Changhai Hospital
  Recruiting
• Iloprost in Acute Respiratory Distress Syndrome

  NCT03111212

  Condition:   Respiratory Distress Syndrome, Adult
  Interventions:   Drug: Iloprost;   Drug: control
  Sponsor:   University Hospital Tuebingen
  Recruiting
• Mesenchymal Stromal Cells For Acute Respiratory Distress Syndrome

  NCT03818854

  Condition:   Respiratory Distress Syndrome, Adult
  Interventions:   Biological: Human Mesenchymal Stromal Cells;   Biological: Cell Reconstitution Media
  Sponsors:   Michael A. Matthay;   United States Department of Defense;   Harborview Injury Prevention and Research Center;   Oregon Health and Science University;   Vanderbilt University Medical Center;   The University of Texas Health Science Center, Houston;   University of Minnesota - Clinical and Translational Science Institute
  Not yet recruiting
• Repair of Acute Respiratory Distress Syndrome by Stromal Cell Administration (REALIST)

  NCT03042143

  Condition:   Acute Respiratory Distress Syndrome
  Interventions:   Biological: Human umbilical cord derived CD362 enriched MSCs;   Biological: Placebo (Plasma-Lyte 148)
  Sponsors:   Belfast Health and Social Care Trust;   Queen's University, Belfast;   Northern Ireland Clinical Trials Unit;   NHS Blood and Transplant
  Recruiting
• Establishment of a Biomarkers-based Early Warning System of Acute Respiratory Distress Syndrome (ARDS)

  NCT03236272

  Condition:   Respiratory Distress Syndrome, Adult
  Intervention:  
  Sponsor:   Mingdong Hu
  Recruiting
• Sigh Ventilation to Increase Ventilator-Free Days in Victims of Trauma at Risk for Acute Respiratory Distress Syndrome

  NCT02582957

  Condition:   Acute Respiratory Distress Syndrome
  Intervention:   Other: Sigh breaths
  Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   United States Department of Defense;   University of Colorado, Denver
  Recruiting
• Acute Respiratory Distress Syndrome in Taiwan

  NCT03260348

  Condition:   Acute Respiratory Distress Syndrome
  Intervention:  
  Sponsor:   Chang Gung Memorial Hospital
  Not yet recruiting
• Pediatric Acute Respiratory Distress Syndrome Ventilation Bundle

  NCT03504176

  Condition:   Acute Respiratory Distress Syndrome
  Intervention:   Other: Ventilation bundle
  Sponsor:   KK Women's and Children's Hospital
  Recruiting
• Adaptive Support Ventilation in Acute Respiratory Distress Syndrome

  NCT03715751

  Condition:   Acute Respiratory Distress Syndrome
  Interventions:   Other: ASV;   Other: Lung Protective Ventilation
  Sponsor:   Beth Israel Deaconess Medical Center
  Recruiting
• Immune Alveolar Alterations During Pneumonia-Associated Acute Respiratory Distress Syndrome

  NCT03971006

  Condition:   Acute Respiratory Distress Syndrome
  Intervention:  
  Sponsor:   Assistance Publique - Hôpitaux de Paris
  Not yet recruiting
• N-Acetyl-cysteine in Early Acute Respiratory Distress Syndrome

  NCT03346681

  Condition:   Acute Respiratory Distress Syndrome
  Intervention:   Drug: N-acetyl cysteine
  Sponsor:   Prisma Health-Midlands
  Recruiting
• Safety and Efficacy Study of Inhaled Carbon Monoxide to Treat Acute Respiratory Distress Syndrome (ARDS)

  NCT03799874

  Condition:   Acute Respiratory Distress Syndrome
  Interventions:   Drug: Inhaled Carbon Monoxide at 200ppm;   Other: Inhaled Medical air
  Sponsors:   Brigham and Women's Hospital;   Massachusetts General Hospital;   Weill Medical College of Cornell University;   Duke University;   Durham VA Medical Center
  Recruiting
• Individualized Positive End-expiratory Pressure Guided by End-expiratory Lung Volume in the Acute Respiratory Distress Syndrome

  NCT04012073

  Condition:   Respiratory Distress Syndrome, Adult
  Interventions:   Device: Invasive Mechanical ventilation;   Drug: Neuromuscular Blocking Agents;   Procedure: Prone positioning;   Procedure: Resume of spontaneous breathing;   Procedure: Rescue treatments;   Procedure: Weaning from PEEP;   Procedure: Weaning from mechanical ventilation;   Procedure: Extubation
  Sponsors:   Fondazione Policlinico Universitario Agostino Gemelli IRCCS;   ClinicalTrialCenter;   FerrarioDati;   General Electric
  Not yet recruiting
• Prediction of Outcomes With a Miniaturized Transesophageal Echocardiography Probe in Patients With Acute Respiratory Distress Syndrome

  NCT03763773

  Condition:   Acute Respiratory Distress Syndrome
  Intervention:  
  Sponsor:   University Hospital, Lille
  Recruiting
• Efficacy and Safety Study of HLCM051(MultiStem®) for Pneumonic Acute Respiratory Distress Syndrome

  NCT03807804

  Condition:   Respiratory Distress Syndrome, Adult
  Intervention:   Biological: HLCM051
  Sponsor:   Healios K.K.
  Recruiting
• The Strategy of "Pulmonary Opening by Titration of Positive End-expiratory Pressure" Means of a Pulmonary Recruitment Maneuver in Patients With Acute Respiratory Distress Syndrome: for Which Patients?

  NCT04028336

  Condition:   Respiratory Distress Syndrome, Adult
  Intervention:   Other: TITRATION
  Sponsor:   Centre Hospitalier de Lens
  Not yet recruiting
• Post-discharge Outcomes of Pediatric Acute Respiratory Distress Syndrome

  NCT03585582

  Condition:   Pediatric Acute Respiratory Distress Syndrome
  Intervention:   Other: Prospective follow-up
  Sponsors:   St. Justine's Hospital;   Canadian Institutes of Health Research (CIHR)
  Not yet recruiting
• Epidemiological Study of Neonatal Acute Respiratory Distress Syndrome (ARDS)

  NCT03311165

  Condition:   Neonatal Acute Respiratory Distress Syndrome(ARDS)
  Intervention:   Other: no intervention
  Sponsors:   Daping Hospital and the Research Institute of Surgery of the Third Military Medical University;   Daping Hospital of Army Medical University;   Jiulongpo No.1 People's Hospital;   Guiyang Maternity and Child Health Care Hospital;   Yan'an Affiliated Hospital of Kunming Medical University;   The Children's Hospital of Zhejiang University School of Medicine;   Lanzhou General Hospital of PLA;   Changhai hospital of Navy Medical University;   General hospital of Rocket Army;   No 252 hospital of PLA;   No 301 hospital of PLA;   No 88 hospital of PLA;   Xinqiao hospital of Army Medical University;   Bethune International Peace Hospital;   No 251 hospital of PLA;   People's Hospital of Xinjiang Uygur Autonomous Region;   Children's Hospital of Chongqing Medical University;   Gansu Provincial Maternity and Child-Care Hospital;   Chengdu Women and Children's Center Hospital;   Children hospital of Hunan Province;   Wuhan general hospital of PLA;   Jinan general hospital of PLA;   The 306 Hospital of People's Liberation Army;   No 452 hospital of PLA;   Xijing hospital of air force Medical University;   307 Hospital of PLA;   No 202 hospital of PLA;   Tianjin armed police children hospital;   Beijing 302 Hospital;   Xinan hospital of Army Medical University;   Southern Medical University, China;   Children Hospital of Fudan University;   NorthWest Women and Children Hospital;   First Affiliated Hospital of Xinjiang Medical University;   No 155 hospital of PLA;   Guangzhou general hospital of PLA;   Urumqi general hospital of PLA;   No 211 hospital of PLA;   First Affiliated Hospital of Harbin Medical University
  Recruiting
• Measurement of Lung Elastance and Transpulmonary Pressure Using Two Different Methods (Lungbarometry)

  NCT02948530

  Condition:   Acute Lung Injury
  Intervention:  
  Sponsor:   Stefan Lundin
  Recruiting
• Clinical Evaluation of a Point of Care (POC) Assay to Identify Phenotypes in the Acute Respiratory Distress Syndrome

  NCT04009330

  Condition:   Acute Respiratory Distress Syndrome (ARDS)
  Intervention:   Diagnostic Test: POC Assay
  Sponsors:   Queen's University, Belfast;   Northern Ireland Clinical Trials Unit;   Innovate UK
  Not yet recruiting
• Safety Study of Inhaled Carbon Monoxide to Treat Acute Respiratory Distress Syndrome (ARDS)

  NCT02425579

  Condition:   Acute Respiratory Distress Syndrome (ARDS)
  Interventions:   Drug: Inhaled Carbon Monoxide at 100ppm (4 participants);   Drug: Placebo for Inhaled Carbon Monoxide at 100ppm (2 participants);   Drug: Inhaled Carbon Monoxide at 200ppm (4 participants);   Drug: Placebo for Inhaled Carbon Monoxide at 200ppm (2 participants);   Drug: Open-label algorithm-specified dose of iCO to achieve COHb of 6-8% (6 participants)
  Sponsors:   Brigham and Women's Hospital;   Weill Medical College of Cornell University;   Massachusetts General Hospital;   Duke University
  Recruiting
• The Study of ELEctronic Cigarette Toxicity in a Human Model in Vivo Model of Inflammation and Vascular Dysfunction

  NCT02739438

  Condition:   Acute Lung Injury
  Interventions:   Other: Electronic cigarette use;   Other: Cigarette use;   Other: Control group
  Sponsor:   Queen's University, Belfast
  Recruiting
• Prevention of Ulinastatin on Acute Respiratory Distress Syndrome (ARDS)

  NCT03089957

  Conditions:   Acute Respiratory Distress Syndrome;   Critical Illness
  Interventions:   Drug: Ulinastatin;   Other: Usual care
  Sponsors:   Peking University Third Hospital;   Chinese PLA General Hospital;   The First Affiliated Hospital of Zhengzhou University;   Peking University Shenzhen Hospital;   Central Hospital of Zi Bo;   Beijing Anzhen Hospital;   The Second Affiliated Hospital of Dalian Medical University;   First Affiliated Hospital of Guangxi Medical University;   Beijing Shijitan Hospital Affiliated to Capital Medical University
  Recruiting
• Electrical Impedance Tomography for Optimization of Positive End-Expiratory Pressure: Acute Respiratory Distress Syndrome

  NCT03793842

  Conditions:   Acute Respiratory Distress Syndrome;   ARDS
  Interventions:   Other: Usual care;   Device: PEEP titration by EIT
  Sponsor:   University of Michigan
  Recruiting
• Transfusion of Red Blood Cells for Acute Respiratory Distress Syndrome(ARDS) in Neonates

  NCT03296059

  Conditions:   Red Blood Cells(RBC);   Acute Respiratory Distress Syndrome (ARDS)
  Interventions:   Other: conventional treatment with RBC transfusion;   Other: conventional treatment
  Sponsor:   Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
  Recruiting
• Invasive Ventilation for Neonates With Acute Respiratory Distress Syndrome(ARDS)

  NCT03591796

  Conditions:   Acute Respiratory Distress Syndrome;   Conventional Mechanical Ventilation;   High Frequency Oscillation Ventilation
  Interventions:   Device: HFOV;   Device: CMV
  Sponsors:   Daping Hospital and the Research Institute of Surgery of the Third Military Medical University;   Children's Hospital of Chongqing Medical University;   Jiulongpo No.1 People's Hospital;   Chongqing Maternal and Child Health Hospital;   The First Affiliated Hospital of Anhui Medical University;   Children’s Hospital of The Capital Institute of Pediatrics;   Peking University Third Hospital;   First Hospital of Tsinghua University;   Women and Children's Hospital, Branch of Chongqing Sanxia Central Hospital;   First Affiliated Hospital of Chongqing Medical University;   Quanzhou Children's Hospital;   Xiamen Maternity & Child Care Hospital;   Zhujiang Hospital;   Guangdong Academy of Medical Science and General Hospital;   Guangdong Women and Children Hospital;   Women and Children’s Health Hospital of Yulin;   Women and Children Health Care Hospitalof GuangXi Zhuang Autonomous;   Second Affiliated Hospital of Guangzhou Medical University;   Guiyang Maternal and Child Health Care Hospital;   Zunyi First People's Hospital;   Second Hospital of Lanzhou University;   Gansu Provincial Maternity and Child-Care Hospital;   LanZhou University;   First Affiliated Hospital of Harbin Medical University;   First Affiliated Hospital of Xinjiang Medical University;   Zhengzhou Children's Hospital, China;   Third Affiliated Hospital of Zhengzhou University;   the Maternal and Child Health Hospital of Hainan Province;   Bethune International Peace Hospital;   Wuhan Union Hospital, China;   Children’s Hospital of Nanjing Medical University;   First Hospital of Jilin University;   Children's Hospital of Fudan University;   Maternal and Children’s Healthcare Hospital of Taian;   The Second Hospital of Shandong University;   Shanxi Provincial Maternity and Children's Hospital;   Chengdu Women and Children's Center Hospital;   The Affiliated Hospital Of Southwest Medical University;   Affiliated Hospital of Southwest Medical University;   Shenzhen People’s Hospital, The Second Medical College of Jinan University;   Tianjin Central Hospital of Gynecology Obstetrics;   People's Hospital of Xinjiang Uygur Autonomous Region;   Kunming Children's Hospital;   The First People's Hospital of Yunnan;   The First Affiliated Hospital of Kunming Medical College;   Yan’an Hospital Affiliated to Kunming Medical University;   Women and Children’s Health Hospital of Qujing;   The People's Hospital of Dehong Autonomous Prefecture;   Yinchuan No 1 people’s Hospital Affiliated of Ningxia Medical University;   The Children's Hospital of Zhejiang University School of Medicine;   Women's Hospital School Of Medicine Zhejiang University;   Beijing 302 Hospital;   Hunan Children's Hospital;   Women and Children Hospital of Qinghai Province;   Jiangxi Province Children's Hospital;   Inner Mongolia People's Hospital;   Mianyang Central Hospital;   People's Liberation Army No.202 Hospital;   Ningbo Women & Children's Hospital;   Shanghai Children's Medical Center;   First Affiliated Hospital of Guangxi Medical University;   Nanjing Medical University;   Qinhuangdao Maternal and Child Health Care Hospital;   Xuzhou Children Hospital;   The First Affiliated Hospital of Zhengzhou University;   Xianyang children’s Hospital
  Recruiting
• Clinical Decision Support for Mechanical Ventilation of Patients With ARDS

  NCT03984175

  Condition:   Acute Respiratory Distress Syndrome
  Intervention:   Procedure: Implementation of Processes
  Sponsors:   Intermountain Health Care, Inc.;   National Institutes of Health (NIH);   McKay-Dee Hospital;   Utah Valley Hospital;   Dixie Regional Hospital
  Recruiting
• Human Umbilical Cord Mesenchymal Stem Cells (MSCs) Therapy in ARDS

  NCT03608592

  Condition:   Acute Respiratory Distress Syndrome
  Interventions:   Biological: umbilical cord derived mesenchymal stem cells (UCMSCs) suspension;   Biological: normal saline
  Sponsor:   Sun Yat-sen University
  Not yet recruiting
• Comparison of Positive End Expiratory Pressure Titration Methods in ARDS Patients

  NCT03281473

  Condition:   Acute Respiratory Distress Syndrome
  Interventions:   Other: Strategy 1;   Other: Strategy 2
  Sponsor:   University Hospital, Angers
  Recruiting
• A Strategy to Improve Implementation of LTVV for Patients w/ ARDS

  NCT03051139

  Condition:   Acute Respiratory Distress Syndrome
  Intervention:   Behavioral: Multi-component LTVV implementation strategy
  Sponsors:   Northwestern University;   National Heart, Lung, and Blood Institute (NHLBI)
  Not yet recruiting
• A Comparison of Optimal PEEP Determination Guided by EIT and G5 Device in Moderate and Severe ARDS Patients

  NCT03112512

  Condition:   Acute Respiratory Distress Syndrome
  Interventions:   Device: optimal PEEP guided by EIT;   Device: optimal PEEP guided by G5 ventilator
  Sponsor:   Mei-Yun Chang
  Recruiting
• Evaluation of Safety & Efficacy of BIO-11006 Inhalation Solution in Patients With ARDS

  NCT03202394

  Condition:   Respiratory Distress Syndrome, Adult
  Interventions:   Drug: BIO-11006;   Drug: Placebo
  Sponsor:   BioMarck Pharmaceuticals, Ltd.
  Recruiting
• Invasive Ventilation Strategies for Neonates With Acute Respiratory Distress Syndrome Syndrome (ARDS)

  NCT03372525

  Conditions:   Acute Respiratory Distress Syndrome;   Bronchopulmonary Dysplasia;   High Frequency Oscillation Ventilation
  Interventions:   Device: HFOV;   Device: CMV
  Sponsors:   Daping Hospital and the Research Institute of Surgery of the Third Military Medical University;   Children's Hospital of Chongqing Medical University
  Recruiting
• Treprostinil Sodium Inhalation for Patients At High Risk for ARDS

  NCT02370095

  Condition:   Respiratory Distress Syndrome, Adult
  Interventions:   Drug: Treprostinil Inhalation Solution;   Drug: Placebo
  Sponsors:   University of North Carolina, Chapel Hill;   United Therapeutics
  Recruiting
• Imaging of Peri-operative (periOP) Lung Injury

  NCT02978885

  Conditions:   Acute Lung Injury;   Chronic Obstructive Pulmonary Disease (COPD)
  Interventions:   Radiation: SPECT-CT imaging;   Drug: AxV-128/Tc
  Sponsors:   Columbia University;   National Heart, Lung, and Blood Institute (NHLBI)
  Recruiting
• Identifying PARDS Endotypes

  NCT03539783

  Conditions:   Respiratory Distress Syndrome;   Respiratory Distress Syndrome, Adult
  Intervention:   Diagnostic Test: Respiratory epithelial cell brushing
  Sponsor:   Children's Hospital Medical Center, Cincinnati
  Recruiting
• Artificial Increase in Chest Wall Elastance as an Alternative to Prone Positioning in Moderate-to-severe ARDS.

  NCT03719937

  Condition:   Acute Respiratory Distress Syndrome
  Intervention:   Device: weight on the anterior chest of the patient
  Sponsor:   Catholic University of the Sacred Heart
  Recruiting
• A Comparison of Optimal PEEP Determination Guided by EIT and Conventional Protective Ventilation Tool in ARDS Patients

  NCT03498807

  Conditions:   ARDS;   Acute Respiratory Distress Syndrome
  Interventions:   Device: Ventiltor P/V Loop;   Device: Electrical Impedance Tomography
  Sponsor:   Hui-Ju Hsu
  Recruiting
• Determination of the Best Positive End-expiratory Pressure (PEEP)

  NCT03969407

  Conditions:   Positive Expiratory Pressure;   Acute Respiratory Distress Syndrome
  Intervention:  
  Sponsor:   Centre Chirurgical Marie Lannelongue
  Recruiting
• Inflammation and Distribution of Pulmonary Ventilation Before and After Tracheal Intubation in ARDS Patients

  NCT03513809

  Conditions:   Acute Hypoxemic Respiratory Failure;   Acute Respiratory Distress Syndrome
  Intervention:   Device: Thoracic electrical impedance tomography
  Sponsors:   Pontificia Universidad Catolica de Chile;   Comisión Nacional de Investigación Científica y Tecnológica
  Recruiting
• The Value of Combined Critical Care Ultrasound and PAC Monitor Oriented Therapy Protocol to Patients of ARDS With ACP

  NCT03971331

  Conditions:   Respiratory Distress Syndrome, Adult;   Ventricular Dysfunction, Right
  Intervention:   Device: PAC catheter and critical care ultrasound examination
  Sponsor:   Kang Yan
  Not yet recruiting
• Long Term Outcome on Brain and Lung of Different Oxygen Strategies in ARDS Patients

  NCT03621293

  Condition:   Acute Respiratory Distress Syndrome
  Intervention:   Drug: Modulation of Inspired Fraction of Oxygen (FiO2)
  Sponsor:   Centre Hospitalier Universitaire de Besancon
  Recruiting
• Continuous Negative Abdominal Pressure in ARDS (CNAP in ARDS)

  NCT03425318

  Condition:   Acute Respiratory Distress Syndrome
  Intervention:   Device: CNAP
  Sponsors:   The Hospital for Sick Children;   St. Michael's Hospital, Toronto
  Not yet recruiting
• Sevoflurane PharmacokInetics in ARDS

  NCT04023305

  Condition:   Acute Respiratory Distress Syndrome
  Intervention:   Drug: Deep sedation by Sevoflurane on the Morphotype of ARDS in ICU patieNts
  Sponsor:   University Hospital, Clermont-Ferrand
  Not yet recruiting
• STUDY OF ELECTRICAL STIMULATION IN PULMONARY FUNCTION IN INTENSIVE CARE UNIT

  NCT03712215

  Condition:   Respiratory Distress Syndrome, Adult
  Intervention:   Other: Rehabilitation
  Sponsors:   Universidade Metodista de Piracicaba;   Universidade do Estado do Pará
  Recruiting
• Non-invasive Fluid Management

  NCT02892799

  Condition:   Respiratory Distress Syndrome, Adult
  Interventions:   Other: NICOM-Guided Diuresis;   Other: Standard of Care
  Sponsor:   Intermountain Health Care, Inc.
  Recruiting
• New Lung Ventilation Strategies Guided by Transpulmonary Pressure in VV-ECMO for Severe ARDS

  NCT02439151

  Condition:   Respiratory Distress Syndrome, Adult
  Interventions:   Device: New lung ventilation strategy;   Device: Conventional ventilation strategy
  Sponsor:   Rui Wang
  Recruiting
• Ultra-protective Pulmonary Ventilation Supported by Low Flow ECCO2R for Severe ARDS

  NCT02252094

  Condition:   Respiratory Distress Syndrome, Adult
  Interventions:   Device: Prismalung;   Other: Ultra-protective ventilation;   Other: Conventional Lung Protective Ventilation
  Sponsors:   National University Health System, Singapore;   Baxter Healthcare Corporation
  Recruiting
• Hemoglobin Concentration in Patients With an Acute Respiratory Distress Syndrome

  NCT03871166

  Condition:   ARDS, Human
  Intervention:   Other: Blood transfusion
  Sponsor:   Charite University, Berlin, Germany
  Recruiting
• Heliox for Neonate With Acute Respiratory Distress Syndrome (ARDS)

  NCT03217149

  Condition:   ARDS
  Interventions:   Drug: heliox combined with MV;   Drug: MV
  Sponsor:   Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
  Recruiting
• Surfactant for Neonate With Acute Respiratory Distress Syndrome (ARDS)

  NCT03217162

  Condition:   ARDS
  Interventions:   Drug: surfactant combined with mechanical ventilation (MV);   Drug: mechanical ventilation (MV)
  Sponsor:   Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
  Recruiting
• Procollagen-3 Driven Corticosteroids for Persistent Acute Respiratory Distress Syndrome

  NCT03371498

  Condition:   Persistent ARDS
  Interventions:   Drug: Methylprednisolone;   Drug: Methylprednisolone placebo
  Sponsor:   Assistance Publique Hopitaux De Marseille
  Recruiting
• Validation of a Semi-automatized Method to Detect Cyclic Hyperinflation on CT-scan in ARDS

  NCT03870009

  Condition:   Acute Respiratory Distress Syndrome (ARDS)
  Intervention:   Other: ARDS patients
  Sponsor:   Hospices Civils de Lyon
  Recruiting
• The Effect of Negatively Fluid Balancing Speed for ICU Patients With Acute Respiratory Distress Syndrome

  NCT03552601

  Condition:   Fluid Loss
  Interventions:   Other: traditional speed;   Other: faster speed
  Sponsor:   Qingdao University
  Recruiting
• PROSpect: Prone and Oscillation Pediatric Clinical Trial

  NCT03896763

  Condition:   Acute Respiratory Distress Syndrome in Children
  Intervention:   Other: Either supine or prone positioning and either CMV or HFOV
  Sponsors:   University of Pennsylvania;   National Heart, Lung, and Blood Institute (NHLBI);   Duke University;   University Medical Center Groningen;   Boston Children’s Hospital
  Recruiting
• Molecular Epidemiology of ARDS

  NCT00006496

  Conditions:   Acute Respiratory Distress Syndrome;   Lung Diseases
  Intervention:  
  Sponsors:   Massachusetts General Hospital;   National Heart, Lung, and Blood Institute (NHLBI)
  Recruiting
• A Multiple Centre,Random Control Study :Early Use of Airway Pressure Release Ventilation (APRV) Plus Protocol in ARDS

  NCT03549910

  Condition:   Acute Respiratory Distress Syndrome
  Interventions:   Procedure: APRVplus protocol;   Procedure: Low tidal volume ventilation
  Sponsor:   West China Hospital
  Not yet recruiting
• Pilot RCT of Therapeutic Hypothermia Plus Neuromuscular Blockade in ARDS Patients

  NCT03376854

  Condition:   Respiratory Distress Syndrome, Adult
  Interventions:   Device: Hypothermia;   Drug: Neuromuscular Blocking Agents;   Device: Standard of Care
  Sponsor:   University of Maryland, Baltimore
  Recruiting
• Acute Respiratory Distress Syndrome(ARDS) in Neonates

  NCT03227289

  Conditions:   ARDS;   NRDS
  Interventions:   Other: Stayed in NRDS;   Other: Converted to ARDS
  Sponsor:   Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
  Recruiting
• Selective High Frequency Oscillatory Ventilation (HFOV) for Neonates

  NCT03736707

  Conditions:   Respiratory Distress Syndrome;   Acute Respiratory Distress Syndrome;   High Frequency Oscillatory Ventilation
  Interventions:   Device: Selective HFOV;   Device: CMV
  Sponsors:   Daping Hospital and the Research Institute of Surgery of the Third Military Medical University;   Children's Hospital of Chongqing Medical University;   Jiulongpo No.1 People's Hospital;   Chongqing Maternal and Child Health Hospital;   The First Affiliated Hospital of Anhui Medical University;   Children’s Hospital of The Capital Institute of Pediatrics;   Peking University Third Hospital;   First Hospital of Tsinghua University;   Women and Children's Hospital, Branch of Chongqing Sanxia Central Hospital;   First Affiliated Hospital of Chongqing Medical University;   Quanzhou Children's Hospital;   Xiamen Maternity & Child Care Hospital;   Zhujiang Hospital;   Nanfang Hospital of Southern Medical University;   Guangdong Academy of Medical Science and General Hospital;   Guangdong Women and Children Hospital;   Women and Children’s Health Hospital of Yulin;   Women and Children Health Care Hospitalof GuangXi Zhuang Autonomous;   Second Affiliated Hospital of Guangzhou Medical University;   Guiyang Maternal and Child Health Care Hospital;   Zunyi First People's Hospital;   Second Hospital of Lanzhou University;   Gansu Provincial Maternity and Child-Care Hospital;   LanZhou University;   First Affiliated Hospital of Harbin Medical University;   First Affiliated Hospital of Xinjiang Medical University;   Zhengzhou Children's Hospital, China;   Third Affiliated Hospital of Zhengzhou University;   the Maternal and Child Health Hospital of Hainan Province;   Bethune International Peace Hospital;   Wuhan Union Hospital, China;   Children’s Hospital of Nanjing Medical University;   First Hospital of Jilin University;   Children's Hospital of Fudan University;   Maternal and Children’s Healthcare Hospital of Taian;   The Second Hospital of Shandong University;   Shanxi Provincial Maternity and Children's Hospital;   Chengdu Women and Children's Center Hospital;   The Affiliated Hospital Of Southwest Medical University;   Affiliated Hospital of Southwest Medical University;   Shenzhen People’s Hospital, The Second Medical College of Jinan University;   Tianjin Central Hospital of Gynecology Obstetrics;   People's Hospital of Xinjiang Uygur Autonomous Region;   Kunming Children's Hospital;   The First People's Hospital of Yunnan;   The First Affiliated Hospital of Kunming Medical College;   Yan’an Hospital Affiliated to Kunming Medical University;   Women and Children’s Health Hospital of Qujing;   The People's Hospital of Dehong Autonomous Prefecture;   Yinchuan No 1 people’s Hospital Affiliated of Ningxia Medical University;   The Children's Hospital of Zhejiang University School of Medicine;   Women's Hospital School Of Medicine Zhejiang University;   Beijing 302 Hospital;   Hunan Children's Hospital;   Women and Children Hospital of Qinghai Province;   Jiangxi Province Children's Hospital;   Inner Mongolia People's Hospital;   Mianyang Central Hospital;   People's Liberation Army No.202 Hospital;   Ningbo Women & Children's Hospital;   Shanghai Children's Medical Center;   First Affiliated Hospital of Guangxi Medical University;   Nanjing Medical University;   Xianyang children’s Hospital;   Qinhuangdao Maternal and Child Health Care Hospital;   Xuzhou Children Hospital
  Recruiting
• Effect of Inhalation Sedation Compared With Propofol on the Sepsis-related Acute Respiratory Distress Syndrome Course

  NCT04014218

  Condition:   ARDS
  Interventions:   Drug: Inhalation Sedation;   Drug: Intravenous Sedation
  Sponsors:   Moscow Regional Research and Clinical Institute Moniki n.a. M.F. Vladimirskiy;   I.M. Sechenov First Moscow State Medical University
  Recruiting
• PGE1 as Additive Anticoagulant in ECMO-Therapy

  NCT02895373

  Conditions:   Respiratory Distress Syndrome, Adult;   Extracorporeal Membrane Oxygenation
  Interventions:   Drug: Alprostadil;   Drug: 0.9% sodium chloride solution
  Sponsor:   Thomas Staudinger
  Recruiting
• A Modified Mathematical Model to Calculate Power Received by Mechanically Ventilated Patients With Different Etiologies

  NCT04046380

  Condition:   Acute Respiratory Distress Syndrome, Mechanical Ventilation, Respiratory Mechanics, Ventilator-induced Lung Injury
  Intervention:   Diagnostic Test: work of breath measurement and calculation
  Sponsor:   Changhua Christian Hospital
  Not yet recruiting
• Careful Ventilation in Acute Respiratory Distress Syndrome

  NCT03963622

  Condition:   ARDS
  Interventions:   Other: Respiratory Mechanics;   Other: Standard Ventilation Strategy
  Sponsor:   St. Michael's Hospital, Toronto
  Not yet recruiting
• Mitochondrial Dysfunction of Alveolar and Circulating Immune Cells During Acute Respiratory Distress Syndrome: Impact of Infectious Aggression and Alveolar Stretching as a Result of Mechanical Ventilation.

  NCT03955887

  Conditions:   Lung Diseases;   Mechanical Ventilation;   Bronchoalveolar Lavage
  Interventions:   Biological: bronchoalveolar lavage fluid (BAL);   Biological: Venous blood
  Sponsor:   Centre Hospitalier Universitaire Dijon
  Recruiting
• Effect of Randomization to Neuromuscular Blockade on Physical Functional Impairment and Recovery in ARDS

  NCT03038906

  Conditions:   Acute Respiratory Distress Syndrome;   Neuromyopathies
  Intervention:  
  Sponsor:   University of Washington
  Recruiting
• Inhaled Dornase Alpha to Reduce Respiratory Failure After Severe Trauma

  NCT03368092

  Conditions:   Multiple Trauma;   Respiratory Distress Syndrome, Adult
  Interventions:   Drug: Dornase Alfa Inhalant Solution [Pulmozyme];   Drug: Placebos
  Sponsor:   University Hospital, Strasbourg, France
  Not yet recruiting
• Sampling in ARDS Patients Under Inhaled Sedation

  NCT03964155

  Condition:   Acute Distress Respiratory
  Intervention:   Biological: Sample
  Sponsor:   University Hospital, Clermont-Ferrand
  Not yet recruiting
• Lung Protection in ARDS Using Neurally Adjusted Ventilatory Assist

  NCT03868982

  Conditions:   ARDS, Human;   Mechanical Ventilation Pressure High
  Intervention:   Device: Neurally adjusted ventilatory assist
  Sponsor:   Fu Jen Catholic University
  Not yet recruiting
• Acute CorPulmonale and ARDS Circulation Protection China Study China (ACPC)

  NCT03827863

  Conditions:   ARDS (Acute Respiratory Distress Syndrome);   Acute Cor Pulmonale
  Intervention:   Device: TTE
  Sponsor:   Peking Union Medical College Hospital
  Not yet recruiting
• Alveolar Recruitment Maneuvers, Intracerebral Hemodynamic and Oxygenation

  NCT02574169

  Conditions:   Cerebral Injuries;   Acute Respiratory Distress Syndrome (ARDS)
  Interventions:   Other: alveolar recruitment maneuvers group 1;   Other: alveolar recruitment maneuvers group 2
  Sponsor:   University Hospital, Toulouse
  Recruiting
• Re-Evaluation of Systemic Early Neuromuscular Blockade and Transthoracic Ultrasound Assessment of the Diaphragm

  NCT03132896

  Conditions:   Acute Respiratory Distress Syndrome;   Diaphragm Injury;   Neuromuscular Blockade
  Intervention:  
  Sponsor:   University Health Network, Toronto
  Recruiting
• Echocardiographic Evaluation in ARDS Patients

  NCT03920189

  Conditions:   Acute Respiratory Distress Syndrome;   Mechanical Ventilation;   Echocardiographic Ultrasound
  Intervention:   Diagnostic Test: echocariographic ultrasound
  Sponsor:   University of Milan
  Recruiting
• Hemodynamic Effects of PEEP in ARDS

  NCT03896802

  Conditions:   Acute Respiratory Distress Syndrome;   Mechanical Ventilation;   ARDS, Human
  Intervention:   Procedure: Physiological assesment
  Sponsor:   University of Milan
  Recruiting
• The Effect of Positive End-Expiratory Pressure on Functional Residual Capacity During Mechanical Ventilation

  NCT03511651

  Conditions:   Mechanical Ventilation;   Acute Respiratory Distress Syndrome;   Functional Residual Capacity
  Intervention:   Procedure: PEEP
  Sponsor:   Capital Medical University
  Not yet recruiting
• Innate Immune Response During Community Acquired Pneumonia

  NCT03379207

  Conditions:   Community-acquired Pneumonia;   Acute Respiratory Distress Syndrome;   Innate Immunity
  Interventions:   Other: Blood samples;   Other: Tracheal Aspirates;   Other: Surplus of Broncho-alveolar lavage fluid
  Sponsor:   University Hospital, Tours
  Recruiting
• Assessing Lung Inhomogeneity During Ventilation for Acute Hypoxemic Respiratory Failure

  NCT03589482

  Conditions:   Acute Respiratory Distress Syndrome;   Mechanical Ventilation Pressure High;   Hypoxemic Respiratory Failure
  Interventions:   Device: Electrical Impedance Tomography;   Other: ExPRESS-derived PEEP level
  Sponsor:   University Health Network, Toronto
  Recruiting
• ECMO for Critically Ill Patients With Respiratory Failure and/or Circulatory Failure

  NCT04031794

  Conditions:   Severe Acute Respiratory Distress Syndrome;   Refractory Hypoxemia
  Intervention:   Device: Extra Corporeal Membrane Oxygenator (ECMO)
  Sponsor:   Mahidol University
  Recruiting
• Cerebrovascular Hemodynamics in Patients With ARDS.

  NCT03949738

  Condition:   ARDS
  Intervention:   Diagnostic Test: Near-infrared spectroscopy-based assessement of cerebral autoregulation.
  Sponsor:   Universitätsklinikum Hamburg-Eppendorf
  Recruiting
• Sigh in Acute Hypoxemic Respiratory Failure

  NCT03201263

  Conditions:   Respiratory Failure;   Acute Respiratory Distress Syndrome;   Ventilator Lung
  Interventions:   Procedure: Sigh;   Procedure: Standard of care
  Sponsors:   Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico;   European Society of Intensive Care Medicine;   University of Milan;   University of Milano Bicocca
  Recruiting
• REstricted Versus Liberal Positive End-Expiratory Pressure in Patients Without ARDS

  NCT03167580

  Condition:   Ventilator-free Days
  Interventions:   Procedure: restricted PEEP;   Procedure: liberal PEEP
  Sponsors:   Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA);   ZonMw: The Netherlands Organisation for Health Research and Development;   Amphia Hospital;   Gelre Hospitals;   Isala;   Maastricht University Medical Center;   Medical Center Haaglanden;   Onze Lieve Vrouwe Gasthuis;   St. Antonius Hospital;   VU University Medical Center;   Westfriesgasthuis;   Spaarne Gasthuis;   HagaZiekenhuis;   Rijnstate Hospital
  Recruiting
• Registry on the EXperience of Extracorporeal CO2 Removal in Intensive Care Units

  NCT02965079

  Conditions:   Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease;   Patients With Acute Respiratory Distress Syndrome
  Intervention:   Device: ECCO2R
  Sponsor:   Rexecor
  Recruiting
• A Study Promoting Critical Illness Recovery in the Elderly-- Pilot

  NCT02963558

  Conditions:   Acute Respiratory Distress Syndrome;   Critical Illness;   Critical Care
  Intervention:   Device: cycle ergometry
  Sponsor:   Wake Forest University Health Sciences
  Recruiting
• Lung Alveolar Recruitment and Individualized PEEP Setting in Patients With ARDS

  NCT02361398

  Condition:   the PEEP Setting of ARDS
  Intervention:   Other: the EIT guide the individualized PEEP Setting
  Sponsor:   Peking Union Medical College Hospital
  Recruiting
• Low Frequency, Ultra-low Tidal Volume Ventilation in Patients With ARDS and VV-ECMO

  NCT03764319

  Conditions:   ARDS;   Acute Lung Injury;   Extracorporeal Membrane Oxygenation;   Respiratory Distress Syndrome;   Respiratory Tract Diseases;   Lung Diseases;   Lung Injury, Acute
  Interventions:   Other: Ultra-protective ventilator settings;   Other: Standard ventilator settings
  Sponsor:   Medical University of Vienna
  Recruiting
• Pragmatic Investigation of Volume Targeted Ventilation-1

  NCT03909854

  Conditions:   Respiratory Failure;   Acute Respiratory Distress Syndrome (ARDS);   Ventilator Lung
  Intervention:   Device: mode of mechanical ventilation
  Sponsor:   Wake Forest University Health Sciences
  Not yet recruiting
• PEEP-induced Changed in RRI as Physiological Background of Ventilator-induced Kidney Injury

  NCT03969914

  Conditions:   Respiratory Distress Syndrome, Adult;   Respiration, Artificial;   Acute Kidney Injury
  Intervention:   Procedure: PEEP changes
  Sponsor:   Università degli Studi di Ferrara
  Recruiting
• The Effects of Music Therapy on Adult Patients Requiring Mechanical Ventilation in the ICU

  NCT03642002

  Conditions:   Acute Respiratory Distress Syndrome;   Acute Hypoxemic Respiratory Failure;   Acute Hypercapnic Respiratory Failure
  Interventions:   Other: Toning;   Other: Ocean drum & SOK melody;   Other: SOK;   Behavioral: Process;   Other: Holding Harmonic Container
  Sponsor:   Icahn School of Medicine at Mount Sinai
  Recruiting
• the Effect of High Dose Ascorbic Acid on Critically Ill Patients With ARDS

  NCT03780933

  Condition:   Acute Respiratory Distress
  Intervention:   Dietary Supplement: vitamin c
  Sponsor:   Misr International University
  Recruiting
• Telehealth-Enhanced Patient-Oriented Recovery Trajectory After ICU

  NCT03926533

  Conditions:   Critical Illness;   Acute Respiratory Distress Syndrome;   Septic Shock
  Intervention:   Other: Telehealth
  Sponsors:   Vanderbilt University;   American Association of Critical-Care Nurses
  Not yet recruiting
• Ultrasonographic Assessment of the Effect of CPB Acute Lung Injury

  NCT03619525

  Condition:   Lung Ultrasound
  Intervention:   Procedure: lung recruitment
  Sponsor:   Cairo University
  Recruiting
• Traumatic Brain Injury Associated Radiological DVT Incidence and Significance Study

  NCT03937947

  Conditions:   Traumatic Brain Injury;   Deep Vein Thrombosis;   Acute Lung Injury;   Ventilator Associated Pneumonia
  Intervention:  
  Sponsors:   NHS Lothian;   Edinburgh Clinical Trials Unit
  Recruiting
• Enhanced Lung Protective Ventilation With ECCO2R During ARDS

  NCT03525691

  Conditions:   ARDS, Human;   Ventilator-Induced Lung Injury
  Intervention:   Device: Low flow Extracorporeal CO2 removal
  Sponsor:   Hôpital Européen Marseille
  Recruiting
• Ventilation's Parameters Applied in Emergency Medicine. A Prospective Observational Study

  NCT03351920

  Conditions:   Mechanical Ventilation;   Acute Respiratory Distress Syndrome;   Protective Ventilation;   Survival
  Intervention:   Other: mechanical ventilation
  Sponsor:   Poitiers University Hospital
  Recruiting
• Efficacy and Safety of Curosurf® in Patients Invasively Ventilated for Severe Bronchiolitis Under 12 Months of Age

  NCT03959384

  Condition:   Bronchiolitis, Viral
  Interventions:   Drug: Curosurf 80Mg/Ml Intratracheal Suspension;   Other: Ambient Air
  Sponsor:   Azienda Ospedaliera Universitaria Integrata Verona
  Recruiting
• STAT-STatin and Aspirin in Trauma

  NCT02901067

  Conditions:   Wounds and Injuries;   Venous Thromboembolism
  Interventions:   Drug: Aspirin and Rosuvastatin;   Drug: Placebo (for Aspirin and Rosuvastatin)
  Sponsor:   Denver Health and Hospital Authority
  Recruiting
• The Evaluation of NETs, Caspase-1 and Cytokines in ARDS Patients

  NCT03227107

  Condition:   ARDS
  Intervention:  
  Sponsors:   Xiangya Hospital of Central South University;   National Natural Science Foundation of China
  Recruiting
• Measuring Heart and Lung Function in Critical Care

  NCT03424798

  Conditions:   Respiratory Distress Syndrome, Adult;   Critical Illness;   Mechanical Ventilation Complication;   Haemodynamic Instability;   Gas Exchange Impairment
  Intervention:   Device: Inspiwave
  Sponsor:   University of Oxford
  Recruiting
• A Clinical Study on Levosimendan Improvement of Prognosis of ARDS Patients by Optimizing Pulmonary Hemodynamics

  NCT04020003

  Condition:   ARDS, Human
  Intervention:   Drug: Levosimendan
  Sponsor:   Shenzhen Second People's Hospital
  Recruiting
• ECCO2R - Mechanical Power Study

  NCT03939260

  Conditions:   ARDS, Human;   Extracorporeal CO2 Removal;   Mechanical Power
  Intervention:   Other: Extracorporeal CO2 Removal
  Sponsor:   University of Milan
  Recruiting
• Decrease of Lesions Induced by Mechanical Ventilation During ARDS

  NCT03918603

  Condition:   ARDS, Human
  Intervention:   Other: ventral décubitus
  Sponsor:   Assistance Publique Hopitaux De Marseille
  Not yet recruiting
• Alveolar Macrophage Programming Following Endotoxin Exposure

  NCT03859050

  Condition:   ARDS, Human
  Intervention:   Other: bronchoscopy with intrabronchial administration of lipopolysaccharide
  Sponsor:   National Jewish Health
  Not yet recruiting
• Clinical Study of Titrating PEEP of Different Methods on Right Heart Function

  NCT03845556

  Condition:   ARDS, Human
  Intervention:  
  Sponsors:   Southeast University, China;   Zhongda Hospital
  Recruiting
• LIght Sedation Pressure Support

  NCT03783468

  Condition:   ARDS, Human
  Intervention:   Other: decrease of sedation doses and switch of ventilator settings
  Sponsor:   University Hospital, Lille
  Not yet recruiting
• Screening Expiratory Flow Limitation by Flow-time Curve

  NCT03215316

  Condition:   ARDS, Human
  Intervention:  
  Sponsor:   St. Michael's Hospital, Toronto
  Recruiting
• Long Term Follow up of Children Enrolled in the REDvent Study

  NCT03709199

  Conditions:   Respiratory Distress Syndrome, Adult;   Ventilator-Induced Lung Injury;   Neurocognitive Dysfunction;   Quality of Life;   Respiration Disorders
  Interventions:   Diagnostic Test: Ventilation Inhomogeneity;   Diagnostic Test: Diaphragm Ultrasound;   Diagnostic Test: Respiratory Inductance Plethysmography;   Diagnostic Test: Spirometry;   Diagnostic Test: Functional Residual Capacity;   Diagnostic Test: MIP/MEP;   Diagnostic Test: 6 minute walk test;   Diagnostic Test: Neurocognitive Testing;   Diagnostic Test: Emotional Health Assessment;   Diagnostic Test: Health Related Quality of Life;   Diagnostic Test: Functional Status;   Diagnostic Test: Respiratory Status Questionnaire
  Sponsor:   Children's Hospital Los Angeles
  Recruiting
• Implementation of Lung Protective Ventilation in Patients With Acute Respiratory Failure

  NCT03225807

  Conditions:   Acute Respiratory Distress Syndrome;   ARDS;   Respiratory Distress Syndrome, Acute;   Respiratory Insufficiency;   Respiratory Distress Syndrome;   Shock Lung;   Severe Acute Respiratory Syndrome
  Intervention:  
  Sponsor:   Intermountain Health Care, Inc.
  Recruiting
• Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Inhalation to Improve Host Defense and Pulmonary Barrier Restoration

  NCT02595060

  Condition:   ARDS
  Interventions:   Drug: inhaled molgramostim (rhGM-CSF);   Drug: inhaled placebo
  Sponsor:   University of Giessen
  Recruiting
• Comparison Between Limited Driving Pressure Ventilation and Conventional Mechanical Ventilation Strategies in Medical Intensive Care Patients With Acute Respiratory Failure

  NCT04035915

  Conditions:   on Invasive Mechanical Ventilation;   ARDS;   Respiratory Failure
  Interventions:   Procedure: Limited driving pressure;   Procedure: Conventional mechanical ventilation strategies
  Sponsor:   Mahidol University
  Recruiting
• METEOR Think NIV Pilot

  NCT04052542

  Condition:   Acute Respiratory Failure
  Interventions:   Behavioral: Traditional online continuing education;   Behavioral: Interprofessional education;   Behavioral: Just-in-time education
  Sponsors:   University of Pittsburgh;   National Heart, Lung, and Blood Institute (NHLBI)
  Not yet recruiting
• Caffeine Treatment in in the Delivery Room

  NCT04044976

  Condition:   Respiratory Distress Syndrome
  Intervention:   Drug: Caffeine Citrate
  Sponsor:   University of Florence
  Not yet recruiting
• HFNC During Bronchoscopy for Bronchoalveolar Lavage

  NCT04016480

  Conditions:   Acute Respiratory Failure;   Bronchoscopy;   Bronchoalveolar Lavage
  Interventions:   Device: High Flow Nasal Cannula;   Device: Conventional Oxygen Therapy
  Sponsor:   University Magna Graecia
  Not yet recruiting
• Respiratory Effect of the LISA Method With Sedation by Propofol Versus Absence of Sedation.

  NCT04016246

  Condition:   Respiratory Distress Syndrome in Premature Infant
  Interventions:   Drug: Propofol-Lipuro;   Drug: Placebos
  Sponsor:   University Hospital, Grenoble
  Not yet recruiting
• Efficacy of High Velocity Nasal Insufflation

  NCT03929055

  Conditions:   Acute Respiratory Failure;   Diaphragmatic Function;   Esophageal Pressure
  Intervention:   Device: Physiological assesment
  Sponsor:   University of Milan
  Recruiting
• Bougie or Stylet In Patients Undergoing Intubation Emergently (BOUGIE)

  NCT03928925

  Condition:   Acute Respiratory Failure
  Interventions:   Other: Bougie;   Other: Endotracheal Tube with Stylet
  Sponsor:   Vanderbilt University Medical Center
  Recruiting
• Evaluation of the Effectiveness of Vibroacoustic Therapy in the Complex Treatment of Acute Respiratory Failure

  NCT03911947

  Condition:   Respiratory Failure
  Intervention:   Device: Vibrolung
  Sponsor:   Astana Medical University
  Recruiting
• Surfactant Administration Via Thin Catheter Using a Specially Adapted Video Laryngoscope

  NCT03846960

  Condition:   Respiratory Distress Syndrome
  Interventions:   Device: using specially adapted VNscope;   Drug: surfactant administration
  Sponsors:   HaEmek Medical Center, Israel;   Carmel Medical Center
  Not yet recruiting
• Patient-ventilator Synchronisation Study for Intensive Care Unit Patients

  NCT03787173

  Condition:   Acute Respiratory Failure
  Interventions:   Device: Optimized;   Device: Automated
  Sponsors:   Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer;   Hamilton Medical AG
  Recruiting
• Effects of Secretion Removal in Ventilated Patients

  NCT03758547

  Condition:   Acute Respiratory Failure
  Interventions:   Device: in-exufflator technique;   Device: percussion technique
  Sponsors:   Azienda Ospedaliera Universitaria di Bologna Policlinico S. Orsola Malpighi;   Fondazione Salvatore Maugeri
  Not yet recruiting
• Cerebral Perfusion and Acute Respiratory Failure

  NCT03733795

  Condition:   Cerebral Blood Flow and Neonates During Acute Respiratory Failure
  Intervention:   Other: TCD
  Sponsors:   Liverpool John Moores University;   Alder Hey Children's NHS Foundation Trust
  Recruiting
• High-Flow Oxygen Therapy Following Tracheostomy

  NCT03721419

  Condition:   Acute Respiratory Failure
  Interventions:   Device: High Flow High Humidity device;   Device: Low Flow High Humidity device
  Sponsor:   Barnes-Jewish Hospital
  Recruiting
• Physiological Changes With High-Flow Nasal Cannula

  NCT03700606

  Condition:   Respiratory Distress Syndrome in Premature Infant
  Interventions:   Procedure: High flow nasal cannula;   Procedure: Nasal CPAP
  Sponsor:   Sharp HealthCare
  Recruiting
• High Flow Nasal Cannulas in Children

  NCT03689686

  Condition:   Acute Respiratory Failure
  Intervention:   Device: Noninvasive Respiratory Support
  Sponsor:   Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
  Recruiting
• Effect of Steroid Administration on Maternal Blood Levels of hLPCAT1 mRNA

  NCT03562182

  Conditions:   Fetal Lung Maturity;   Respiratory Distress Syndrome in Premature Infant
  Intervention:   Other: blood draw
  Sponsor:   Wayne State University
  Recruiting
• Use of Gentle Synchronized Negative Pressure in Helping Babies Breathe

  NCT03510169

  Conditions:   Respiratory Distress Syndrome;   TTN;   RDS of Prematurity;   Respiratory Distress, Newborn
  Intervention:   Device: NeoVest
  Sponsor:   St. Michael's Hospital, Toronto
  Recruiting
• Umbilical Vein Needle Catheterization for Endotracheal Intubation.

  NCT03359993

  Condition:   Infant Respiratory Distress Syndrome
  Intervention:   Procedure: Premedication of intubation
  Sponsor:   Centre Hospitalier René Dubos
  Recruiting
• Nasal Intermittent Positive Pressure Ventilation(NIPPV) vs Continuous Positive Airway Pressure for Respiratory Distress Syndrome

  NCT03226977

  Conditions:   Nasal Intermittent Positive Pressure Ventilation;   Nasal Continuous Positive Airway Pressure
  Interventions:   Device: NIPPV;   Device: NCPAP
  Sponsors:   Daping Hospital and the Research Institute of Surgery of the Third Military Medical University;   Guiyang Maternity and Child Health Care Hospital;   Children's Hospital of Chongqing Medical University;   Chongqing Maternal and Child Health Hospital;   Yan'an Affiliated Hospital of Kunming Medical University;   The Children's Hospital of Zhejiang University School of Medicine;   Chengdu Women's and Children's Central Hospital;   Kunming Children's Hospital;   Shanxi Provincial Maternity and Children's Hospital;   Children's Hospital of Fudan University;   Guangdong Women and Children Hospital;   Nanjing Children's Hospital;   Jiulongpo No.1 People's Hospital
  Recruiting
• Nasal High Frequency Oscillation for Respiratory Distress Syndrome in Twins Infants

  NCT03206489

  Condition:   Nasal High Frequency Oscillation Ventilation
  Interventions:   Device: noninvasive high-frequency ventilation (nHFOV);   Device: nasal continuous positive airway pressure (nCPAP)
  Sponsor:   Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
  Recruiting
• A Trial Comparing Noninvasive Ventilation Strategies in Preterm Infants Following Extubation

  NCT03181958

  Condition:   Intubated Infants Were Intend to Extubation Using Noninvasive Ventilation Strategies
  Interventions:   Device: NHFOV;   Device: NCPAP;   Device: NIPPV
  Sponsors:   Daping Hospital and the Research Institute of Surgery of the Third Military Medical University;   Children's Hospital of Chongqing Medical University;   Jiulongpo No.1 People's Hospital;   Chongqing Maternal and Child Health Hospital;   The First Affiliated Hospital of Anhui Medical University;   Children’s Hospital of The Capital Institute of Pediatrics;   Peking University Third Hospital;   First Hospital of Tsinghua University;   Women and Children's Hospital, Branch of Chongqing Sanxia Central Hospital;   First Affiliated Hospital of Chongqing Medical University;   Quanzhou Children's Hospital;   Xiamen Maternity & Child Care Hospital;   Zhujiang Hospital;   Nanfang Hospital of Southern Medical University;   Guangdong Academy of Medical Science and General Hospital;   Guangdong Women and Children Hospital;   Women and Children’s Health Hospital of Yulin;   Women and Children Health Care Hospitalof GuangXi Zhuang Autonomous;   Second Affiliated Hospital of Guangzhou Medical University;   Guiyang Maternal and Child Health Care Hospital;   Zunyi First People's Hospital;   Second Hospital of Lanzhou University;   Gansu Provincial Maternity and Child-Care Hospital;   LanZhou University;   First Affiliated Hospital of Harbin Medical University;   First Affiliated Hospital of Xinjiang Medical University;   Zhengzhou Children's Hospital, China;   Third Affiliated Hospital of Zhengzhou University;   the Maternal and Child Health Hospital of Hainan Province;   Bethune International Peace Hospital;   Wuhan Union Hospital, China;   Children’s Hospital of Nanjing Medical University;   First Hospital of Jilin University;   Children's Hospital of Fudan University;   Maternal and Children’s Healthcare Hospital of Taian;   The Second Hospital of Shandong University;   Shanxi Provincial Maternity and Children's Hospital;   Chengdu Women and Children's Center Hospital;   The Affiliated Hospital Of Southwest Medical University;   Affiliated Hospital of Southwest Medical University;   Shenzhen People’s Hospital, The Second Medical College of Jinan University;   Tianjin Central Hospital of Gynecology Obstetrics;   People's Hospital of Xinjiang Uygur Autonomous Region;   Kunming Children's Hospital;   The First People's Hospital of Yunnan;   The First Affiliated Hospital of Kunming Medical College;   Yan’an Hospital Affiliated to Kunming Medical University;   Women and Children’s Health Hospital of Qujing;   The People's Hospital of Dehong Autonomous Prefecture;   Yinchuan No 1 people’s Hospital Affiliated of Ningxia Medical University;   The Children's Hospital of Zhejiang University School of Medicine;   Women's Hospital School Of Medicine Zhejiang University;   Beijing 302 Hospital;   Hunan Children's Hospital;   Women and Children Hospital of Qinghai Province;   Jiangxi Province Children's Hospital;   Inner Mongolia People's Hospital;   Mianyang Central Hospital;   People's Liberation Army No.202 Hospital;   Ningbo Women & Children's Hospital;   Shanghai Children's Medical Center;   First Affiliated Hospital of Guangxi Medical University;   Nanjing Medical University;   Qinhuangdao Maternal and Child Health Care Hospital;   Xuzhou Children Hospital;   South Paris University Hospitals, Catholic University of the Sacred Heart;   The First Affiliated Hospital of Zhengzhou University;   Xianyang children’s Hospital
  Recruiting
• Fluid Restriction in Respiratory Distress of the Newborn

  NCT03120585

  Condition:   Respiratory Distress Syndrome, Newborn
  Intervention:   Other: Fluid Management Intervention
  Sponsors:   Abhishek Makkar, MD;   Icahn School of Medicine at Mount Sinai;   Universidad Abierta Interamericana
  Recruiting
• Mobile Critical Care Recovery Program for Acute Respiratory Failure Survivors

  NCT03053245

  Conditions:   Acute Respiratory Failure;   Post-Intensive Care Syndrome
  Interventions:   Behavioral: Mobile Critical Care Program;   Behavioral: Attention Control
  Sponsor:   Indiana University
  Recruiting
• HFNC Alone or Associated With NIV for Immunocompromised Patients Admitted to ICU for Acute Respiratory Failure

  NCT02978300

  Conditions:   Acute Respiratory Failure;   Immunosuppression
  Interventions:   Device: NIV/HFNC;   Device: HFNC
  Sponsor:   Poitiers University Hospital
  Recruiting
• Dexmedetomidine Versus Standard Clinical Practice During Non Invasive Mechanical Ventilation

  NCT02958150

  Condition:   Acute Respiratory Failure
  Interventions:   Drug: Dexmedetomidine;   Procedure: Standard Clinical Practice
  Sponsor:   Basque Health Service
  Recruiting
• Sleep Quality and Risk of Intubation in Intensive Care Units Patients With Hypoxemic Acute Respiratory Failure

  NCT02907008

  Conditions:   Sleep Quality;   Hypoxemic Acute Respiratory Failure;   Intubation Risk
  Intervention:   Other: Polysomnography
  Sponsor:   Poitiers University Hospital
  Recruiting
• Diaphragm Electrical Activity of Preterm Infants on nCPAP Versus NIHFV

  NCT02267018

  Condition:   Respiratory Distress Syndrome, Newborn
  Intervention:   Device: Drager VN500 Ventilator
  Sponsor:   Sunnybrook Health Sciences Centre
  Recruiting
• New Indirect Calorimetry Device for Energy Expenditure Measurement

  NCT02024958

  Condition:   Acute Respiratory Failure
  Intervention:  
  Sponsors:   University Hospital, Geneva;   Helse-Bergen HF;   University of Lausanne Hospitals;   Medical University of Vienna;   Rabin Medical Center;   Karolinska University Hospital
  Recruiting
• Neurally Adjusted Ventilatory Assist (NAVA) Study in Adults With Acute Respiratory Failure

  NCT01730794

  Condition:   Acute Respiratory Failure
  Interventions:   Other: NAVA ventilation;   Other: Conventional Lung Protective Ventilation
  Sponsors:   Massachusetts General Hospital;   Dr. Negrin University Hospital
  Recruiting
• Early Non-invasive Ventilation Outside the Intensive Care Unit

  NCT01572337

  Condition:   Early Acute Respiratory Failure
  Interventions:   Procedure: Non-invasive ventilation;   Other: Standard care
  Sponsor:   Università Vita-Salute San Raffaele
  Recruiting
• Improving Non-invasive Ventilation

  NCT01571986

  Condition:   Acute Respiratory Failure
  Intervention:   Procedure: Non-invasive ventilation
  Sponsor:   Università Vita-Salute San Raffaele
  Recruiting
• Lung Protection Strategy in Open Heart Surgery: Which Tidal Volume is Better 8ml/kg or 6ml/kg

  NCT03651817

  Conditions:   Lung Injury, Acute;   Ventilator-Induced Lung Injury;   Ventilator Adverse Event
  Intervention:   Device: Mechanical ventilation
  Sponsor:   Kocaeli University
  Recruiting
• Recovery From ICUAW Following Severe Respiratory and Cardiac Failure

  NCT03753412

  Conditions:   Intensive Care Unit Syndrome;   Intensive Care Neuropathy;   Intensive Care (ICU) Myopathy;   Acute Respiratory Distress Syndrome;   Cardiac Failure;   Respiratory Failure;   Critical Illness Myopathy
  Intervention:  
  Sponsors:   Barts & The London NHS Trust;   Queen Mary University of London;   Barts Charity
  Recruiting
• pRotective vEntilation With Veno-venouS Lung assisT in Respiratory Failure

  NCT02654327

  Condition:   Acute Respiratory Failure With Hypoxia
  Intervention:   Device: VV-ECCO2R to enable lower tidal volume mechanical ventilation
  Sponsors:   Belfast Health and Social Care Trust;   Queen's University, Belfast;   Northern Ireland Clinical Trials Unit
  Recruiting
• Peer Support for Post Intensive Care Syndrome Self-Management

  NCT03788096

  Conditions:   Critical Illness;   Sepsis;   Shock, Septic;   Shock;   Respiratory Failure;   Respiratory Distress Syndrome, Adult;   Shock, Hypovolemic;   Chronic Disease
  Interventions:   Behavioral: Peer Support with Motivational Interviewing;   Behavioral: Usual Care Group
  Sponsor:   University of Texas at Austin
  Not yet recruiting
• New Automated System for Continuous Real-time Monitoring of Transpulmonary Pressure

  NCT03945409

  Conditions:   Acute Respiratory Failure;   Ventilator-Induced Lung Injury
  Intervention:   Device: OPTIVENT
  Sponsor:   University of Milan
  Recruiting
• Impact of Neurophysiological Facilitation of Respiration in Preterm Neonates

  NCT04019886

  Condition:   Neonatal Respiratory Distress Syndrome
  Intervention:   Other: Neurophysiological Facilitation of Respiration
  Sponsor:   Asir John Samuel
  Not yet recruiting
• Budesonide With Intratracheal Surfactants in Extremely Preterm Infants

  NCT04019106

  Conditions:   Bronchopulmonary Dysplasia;   Respiratory Distress Syndrome in Premature Infant
  Intervention:   Drug: Budesonide in bovine lipid extract surfactant (BLES)
  Sponsors:   University of Manitoba;   Health Sciences Centre, Winnipeg, Manitoba;   St. Boniface General Hospital Research Centre;   Manitoba Institute of Child Health;   University of Utah;   Winnipeg Rh Institute Foundation Inc.;   BLES Biochemicals Inc.
  Not yet recruiting
• Breathing Variability and NAVA in Neonates

  NCT04000568

  Conditions:   Neonatal Respiratory Distress Syndrome;   Prematurity
  Intervention:   Other: Respiratory support: NAVA -NIV and PC-NIV
  Sponsors:   Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico;   Politecnico di Milano
  Recruiting
• SuperNO2VA™ and General Anesthesia Postoperative Care

  NCT03969615

  Conditions:   Hypoxemia;   Acute Respiratory Failure
  Interventions:   Device: SuperNO2VA nasal positive airway pressure devic;   Device: Supplemental oxygen
  Sponsors:   Vyaire Medical;   M.D. Anderson Cancer Center
  Recruiting
• Feasibility and Impact of Volume Targeted Ventilation in the Delivery Room

  NCT03938532

  Conditions:   Prematurity;   BPD - Bronchopulmonary Dysplasia;   Respiratory Distress Syndrome, Newborn
  Interventions:   Device: Volume Targeted Ventilation (VTV) using the Philips Respironics NM3 monitor;   Device: Tidal Volume Measurement using the Philips Respironics NM3 monitor
  Sponsor:   Baystate Medical Center
  Recruiting
• CPAP vs.Unsynchronized NIPPV at Equal Mean Airway Pressure

  NCT03670732

  Conditions:   Prematurity;   Respiratory Distress Syndrome;   Apnea of Prematurity
  Interventions:   Other: continuous positive airway pressure;   Other: nasal intermittent positive pressure ventilation
  Sponsor:   Women and Infants Hospital of Rhode Island
  Recruiting
• High-Flow Nasal Oxygen Cannula Compared to Non-Invasive Ventilation in Adult Patients With AcuTE Respiratory Failure

  NCT03643939

  Conditions:   Respiratory Insufficiency;   Respiratory Failure
  Interventions:   Device: High Flow Nasal Catheter;   Device: Noninvasive ventilation
  Sponsors:   Hospital do Coracao;   Ministry of Health, Brazil;   Berry Consultants
  Not yet recruiting
• Effects of L‑Carnitine Supplementation on Respiratory Distress Syndrome

  NCT03630367

  Condition:   Premature Birth
  Interventions:   Drug: Dexamethasone;   Drug: L-Carnitine 1G/5mL Injection
  Sponsor:   Assiut University
  Recruiting
• Enteral Nutrition Tolerance And REspiratory Support (ENTARES)

  NCT03548324

  Conditions:   Very Low Birth Weight Infant;   Respiratory Distress Syndrome in Premature Infant;   Enteral Feeding Intolerance
  Interventions:   Device: HHHFNC;   Device: NCPAP
  Sponsor:   University of Turin, Italy
  Recruiting
• Surfactant for Neonatal Respiratory Distress Syndrome at High Altitude Areas:a Prospective Cohort Study

  NCT03479450

  Condition:   Surfactant
  Intervention:   Drug: surfactant
  Sponsors:   Daping Hospital and the Research Institute of Surgery of the Third Military Medical University;   the first people hospital of Tibet autonomous region;   the second people hospital of Lasa;   the first people hospital of Shigatse;   the first people hospital of Lasa;   the people hospital of Linzhi;   the people hospital of Laqu
  Not yet recruiting
• Effect of Antenatal Corticosteroids on Neonatal Morbidity.

  NCT03446937

  Condition:   Neonatal Respiratory Distress Syndrome
  Interventions:   Drug: Dexamethasone Sodium Phosphate Injection;   Drug: Betamethasone Sodium Phosphate Injection (Medication);   Drug: Water for injection
  Sponsor:   Ahmadu Bello University Teaching Hospital
  Recruiting
• Behavioral Activation-Rehabilitation to Improve Depressive Symptoms & Physical Function After Acute Respiratory Failure

  NCT03431493

  Conditions:   Respiratory Insufficiency;   Depression;   Rehabilitation;   Critical Care
  Intervention:   Behavioral: Behavioral Activation - Rehabilitation
  Sponsors:   Johns Hopkins University;   National Heart, Lung, and Blood Institute (NHLBI)
  Recruiting
• Comparison of Two Different NCPAP Methods in Preterm Infants With Respiratory Distress Syndrome

  NCT03400670

  Condition:   Ventilatory Failure
  Intervention:   Device: ventilator NCPAP
  Sponsor:   Zekai Tahir Burak Women's Health Research and Education Hospital
  Recruiting
• Intratracheal Budesonide/Surfactant Prevents BPD

  NCT03275415

  Conditions:   Respiratory Distress Syndrome;   Bronchopulmonary Dysplasia
  Interventions:   Drug: budesonide;   Drug: Saline
  Sponsors:   Taipei Medical University;   Taipei Medical University Hospital;   National Taiwan University Hospital;   Taipei Veterans General Hospital, Taiwan;   Mackay Memorial Hospital;   Chung Shan Medical University;   Chang Gung Memorial Hospital;   China Medical University Hospital
  Not yet recruiting
• Tissue Doppler Ultrasound During Spontaneous Breathing and Non-invasive Ventilation in the Post-extubation Period.

  NCT03978221

  Conditions:   Acute Respiratory Failure;   Non-invasive Ventilation
  Intervention:   Other: Post-extubation TDI
  Sponsor:   Azienda Ospedaliero Universitaria Maggiore della Carita
  Recruiting
• A Dose-Ranging Study to Determine the Efficacy, Safety and Tolerability of AeroFact

  NCT03969992

  Condition:   Respiratory Distress Syndrome in Premature Infant
  Interventions:   Drug: AeroFact;   Other: nCPAP
  Sponsor:   Aerogen Pharma Limited
  Not yet recruiting
• Rounding Summaries for Families of Critically Ill Patients

  NCT03969810

  Conditions:   Acute Respiratory Failure;   Intensive Care Unit Syndrome;   Communication
  Intervention:   Behavioral: Rounding Summary
  Sponsor:   Rush University Medical Center
  Not yet recruiting
• Study of Therapeutic Exercise in Acute Respiratory Failure to Improve Neuromuscular Disability Trial

  NCT03863470

  Conditions:   Critical Illness;   Acute Respiratory Failure
  Intervention:   Behavioral: Early mobilization intervention
  Sponsor:   University of Pennsylvania
  Recruiting
• Glycocalyx Biomarkers in ARDS for Clinical Prognosis and Pulmonary Fibrosis

  NCT03854565

  Conditions:   ARDS, Human;   Endothelial Dysfunction;   Mechanical Ventilation Pressure High
  Intervention:   Diagnostic Test: Glycocalyx measurement，respiratory mechanics measurement
  Sponsor:   Southeast University, China
  Not yet recruiting
• NHFOV vs NIPPV vs nCPAP in Preterm Infants With Respiratory Distress Syndrome

  NCT03842462

  Condition:   Preterm Infant
  Interventions:   Other: nCPAP;   Other: NIPPV;   Other: NHFOV
  Sponsor:   Jiulongpo No.1 People's Hospital
  Not yet recruiting
• Ventilatory Monitoring in Children With Respiratory Distress Syndrome With Electrical Impedance Tomography

  NCT03768921

  Condition:   Respiratory Distress Syndrome
  Intervention:   Other: PEEP Titriation
  Sponsors:   Universidade Metodista de Piracicaba;   Universidade do Estado do Pará
  Recruiting
• Study on the Effects of Different Premedication for LISA on Stress and Cerebral Tissue Oxygenation in Preterm Infants

  NCT03718507

  Conditions:   Respiratory Distress Syndrome;   Surfactant Deficiency Syndrome Neonatal;   Near Infrared Spectroscopy
  Interventions:   Drug: Fentanyl;   Drug: Sucrose 24% Oral Solution
  Sponsors:   ASST Fatebenefratelli Sacco;   Gianluca Lista
  Not yet recruiting
• Optimal Settings of Non Invasive Respiratory Support in Preterm Newborns

  NCT03592134

  Conditions:   Preterm Infant;   Respiratory Distress Syndrome
  Intervention:   Other: esophageal pressure measurement
  Sponsor:   Hôpital Necker-Enfants Malades
  Recruiting
• PK of Piperacillin/Tazobactam in Adults Undergoing ECMO

  NCT03467854

  Condition:   Acute Respiratory Failure With Hypoxia
  Intervention:  
  Sponsor:   Columbia University
  Recruiting
• Diaphragmatic Electrical Activity in Preterm Infants on Non-Invasive Ventilation

  NCT03422549

  Conditions:   Respiratory Distress Syndrome, Newborn;   Chronic Lung Disease of Newborn (Diagnosis)
  Intervention:   Device: Drager VN500 Ventilator
  Sponsors:   University of British Columbia;   Sunnybrook Health Sciences Centre
  Recruiting
• RAM Cannula Versus Short Bi-nasal Cannula in Respiratory Distress Syndrome

  NCT03366714

  Condition:   Respiratory Distress Syndrome, Newborn
  Interventions:   Device: nasal CPAP support with RAM cannula;   Device: nasal CPAP support with Hudson cannula
  Sponsor:   Inonu University
  Recruiting
• Conduct of Nasal High Flow Oxygen in Acute Respiratory Failure

  NCT03311087

  Conditions:   Acute Respiratory Failure With Hypoxia;   Hypoxemia
  Intervention:  
  Sponsor:   Hôpital Louis Mourier
  Recruiting
• Bi-level Positive Airway Pressure for Respiratory Distress Syndrome in Twins Infants

  NCT03235661

  Conditions:   nCPAP;   BiPAP;   Respiratory Distress Syndrome
  Interventions:   Device: BiPAP;   Device: nCPAP
  Sponsor:   Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
  Recruiting
• Diaphragm Electrical Activity of Preterm Infants on nCPAP With Binasal Prongs Versus RAM Cannula

  NCT03121781

  Conditions:   Preterm Infants;   Respiratory Distress Syndrome;   CPAP;   RAM Cannula;   Diaphragm Electrical Activity
  Intervention:   Other: respiratory support- interface
  Sponsor:   Sunnybrook Health Sciences Centre
  Recruiting
• Nutrition and Exercise in Critical Illness

  NCT03021902

  Condition:   Acute Respiratory Failure
  Interventions:   Drug: IV amino acids;   Device: In-bed cycle ergometry exercise
  Sponsors:   Clinical Evaluation Research Unit at Kingston General Hospital;   University of Vermont;   Johns Hopkins University
  Recruiting
• NIPPV and nBiPAP Methods in Preterm Infants With Respiratory Distress Syndrome

  NCT02901652

  Conditions:   Prematurity;   Respiratory Distress Syndrome
  Intervention:   Device: noninvasive respiratory support devices
  Sponsor:   Zekai Tahir Burak Women's Health Research and Education Hospital
  Recruiting
• Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: The PROMIZING Study

  NCT02447692

  Conditions:   Critically Ill;   Acute Respiratory Failure
  Interventions:   Other: PSV ventilation strategy;   Other: PAV+ ventilation strategy
  Sponsors:   Lawson Health Research Institute;   Canadian Institutes of Health Research (CIHR);   Medtronic;   Canadian Critical Care Trials Group
  Recruiting
• Surfactant Via Endotracheal Tube vs. Laryngeal Mask Airway (LMA) in Preterm Neonates With Respiratory Distress Syndrome

  NCT02164734

  Condition:   Respiratory Distress Syndrome, Newborn
  Interventions:   Device: Endotracheal intubation;   Device: Laryngeal mask airway;   Drug: remifentanil
  Sponsors:   Albany Medical College;   University of Rochester;   ONY
  Recruiting
• Goal Directed Fluid Therapy Guided Fluid Management in Pneumoresection

  NCT03237351

  Condition:   Goal-directed Fluid Therapy
  Intervention:   Device: Fluid therapy
  Sponsor:   ZhiHeng Liu
  Recruiting
• Automatic Oxygen Control (SPOC) in Preterm Infants

  NCT03785899

  Conditions:   Infantile Respiratory Distress Syndrome;   Ventilator Lung; Newborn
  Interventions:   Device: SPOCnew;   Device: 8s SpO2 averaging;   Device: SPOCold;   Device: 2s SpO2 averaging
  Sponsors:   University Hospital Tuebingen;   Fritz Stephan GmbH
  Recruiting
• Oxygenation Methods and Non-invasive Ventilation in Patients With Acute Respiratory Failure and a do Not Intubate Order

  NCT03673631

  Conditions:   Acute Respiratory Failure;   Cancer;   Hematologic Malignancy;   Cardiac Insufficiency;   Chronic Respiratory Insufficiency
  Interventions:   Device: NIV;   Device: NFHC-O2
  Sponsor:   Poitiers University Hospital
  Recruiting
• High Flow Nasal Oxygen Therapy in Perioperative Period of the Adult With Hypercapnic and Hypoxemic Respiratory Faliure

  NCT03229460

  Condition:   Acute Respiratory Failure With Hypercapnia
  Interventions:   Other: standard low flow therapy;   Device: high flow nasal oxygen therapy;   Device: association of high flow nasal oxygen therapy and non invasive positive pressure ventilation
  Sponsor:   Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
  Recruiting
• 30% or 60% Oxygen at Birth to Improve Neurodevelopmental Outcomes in Very Low Birthweight Infants

  NCT03825835

  Conditions:   Premature Infant;   Respiratory Distress Syndrome in Premature Infant;   Neurodevelopmental Outcome
  Interventions:   Drug: 30% oxygen group;   Drug: 60% oxygen group
  Sponsors:   University of Alberta;   University of Toronto;   University of Sydney;   University of Valencia
  Not yet recruiting
• The Effect of Surfactant Dose on Outcomes in Preterm Infants With RDS

  NCT03808402

  Conditions:   Respiratory Distress Syndrome;   Bronchopulmonary Dysplasia
  Intervention:  
  Sponsors:   Chiesi UK;   Leeds Teaching Hospitals NHS Trust;   Imperial College London
  Recruiting
• Preventing Cardiovascular Collapse With Administration of Fluid Resuscitation During Induction and Intubation

  NCT03787732

  Conditions:   Acute Respiratory Failure;   Intubation Complication;   Hypotension on Induction
  Interventions:   Drug: Fluid Bolus;   Other: No Fluid Bolus
  Sponsor:   Vanderbilt University Medical Center
  Recruiting
• Ventilator Induced Diaphragm Dysfunction in Pediatric Critically Ill Patients (VIDD)

  NCT03768232

  Conditions:   Respiratory Failure;   Respiratory Distress Syndrome;   Mechanical Ventilation Complication
  Intervention:   Other: ultrasound asessment
  Sponsor:   Bambino Gesù Hospital and Research Institute
  Not yet recruiting
• The Safety and Efficacy of FFR Protocol in NTUH System

  NCT03693157

  Conditions:   Bradyarrhythmia;   Dyspnea;   Acute Respiratory Failure
  Intervention:  
  Sponsor:   National Taiwan University Hospital Hsin-Chu Branch
  Not yet recruiting
• A Study To InvestigateThe Safety, Tolerability And Efficacy Of Nebulised Curosurf® In Preterm Neonates With Respiratory Distress Syndrome (RDS)

  NCT03235986

  Condition:   Neonatal Respiratory Distress Syndrome
  Interventions:   Drug: nCPAP (nasal Continuous Positive Airway Pressure) + Nebulised Curosurf® (Part I);   Drug: nCPAP (nasal Continuous Positive Airway Pressure) + Nebulised Curosurf® (Part II);   Other: nCPAP (nasal Continuous Positive Airway Pressure) alone (Part I);   Other: nCPAP (nasal Continuous Positive Airway Pressure) alone (Part II)
  Sponsor:   Chiesi Farmaceutici S.p.A.
  Recruiting
• Does a Rescue Course of Betamethasone in Pregnant Women With PPROM Decrease Neonatal Morbidity?

  NCT02939742

  Conditions:   PPROM;   Respiratory Distress Syndrome in Premature Infants
  Interventions:   Drug: Betamethasone;   Drug: Placebo
  Sponsor:   The University of Texas Medical Branch, Galveston
  Recruiting
• Positive and Quantitative Diagnosis of Pleural Effusions by Thoracic Ultrasonography in Patients With Acute Respiratory Failure in the Emergency Department

  NCT03846934

  Conditions:   Pleural Effusion;   Ultrasonography;   Thoracic;   Acute Respiratory Failure;   Emergencies
  Intervention:   Device: Ultrasonography thoracic
  Sponsor:   University Hospital, Limoges
  Not yet recruiting
• Prehospital High-Flow Nasal Oxygen Therapy

  NCT03326830

  Conditions:   Acute Respiratory Failure With Hypoxia;   Oxygen Inhalation Therapy;   Prehospital Setting
  Interventions:   Device: High-flow nasal oxygen;   Device: Standard oxygen therapy
  Sponsor:   Centre Hospitalier Régional d'Orléans
  Recruiting
• Supplemental Parenteral Nutrition in Pediatric Respiratory Failure

  NCT01937884

  Conditions:   Acute Respiratory Failure With Hypoxia;   Malnutrition
  Intervention:   Drug: Parenteral Nutrition
  Sponsors:   University of Arizona;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
  Recruiting
• Impact of Lidocaine Administration on Postoperative Complications During Lung Resection Surgery

  NCT03905837

  Conditions:   Lung Diseases;   Lung Inflammation;   Lung Injury, Acute;   Postoperative Complications
  Interventions:   Drug: Lidocaine;   Drug: Remifentanil
  Sponsors:   Francisco Andres de la Gala;   Instituto de Salud Carlos III
  Recruiting
• Open Lung Strategy, Gas Distribution and Right Heart Function in ARDS Patients

  NCT03202641

  Conditions:   ARDS, Human;   Lung Injury, Acute;   Respiratory Distress Syndrome;   Mechanical Ventilation Complication;   Alveolar Edema;   Right Heart Failure;   Right Ventricular Dysfunction
  Interventions:   Procedure: PEEP ARDSnet;   Procedure: PEEP LRM
  Sponsor:   Massachusetts General Hospital
  Recruiting
• Assessment of NeuroBOX and NeuroPAP in Infants.

  NCT03650478

  Conditions:   Pediatric Respiratory Diseases;   Bronchiolitis;   Infant Respiratory Distress Syndrome
  Interventions:   Device: NeuroPAP ventilation (2h) and NeuroBox monitoring (23h);   Device: NeuroPAP ventilation (4h) and NeuroBox monitoring (25h)
  Sponsors:   St. Justine's Hospital;   Maquet Critical Care
  Not yet recruiting
• Nasal High-frequency Jet Ventilation (nHFJV) Following Extubation in Preterm Infants

  NCT03558737

  Conditions:   Infant,Premature;   Respiratory Failure;   Respiratory Insufficiency;   Respiratory Distress Syndrome in Premature Infant
  Interventions:   Other: Nasal high-frequency jet ventilation (nHFJV);   Other: Nasal intermittent positive pressure ventilation (NIPPV)
  Sponsor:   University of Utah
  Recruiting
• Efficacy of Adding Budesonide to Poractant Alfa to Prevent Bronchopulmonary Dysplasia.

  NCT03521063

  Conditions:   Bronchopulmonary Dysplasia;   Infant,Premature;   Respiratory Distress Syndrome
  Interventions:   Drug: Budesonide;   Drug: Poractant Alfa;   Drug: Saline
  Sponsors:   Hospital Central "Dr. Ignacio Morones Prieto";   Universidad Autonoma de San Luis Potosí
  Recruiting
• The EXCEL Study: A Comprehensive Bi- National Registry on the Treatment and Outcomes of Patients Requiring ECMO

  NCT03793257

  Conditions:   Critically Ill;   Acute Respiratory Failure;   Acute Heart Failure;   Cardiac Arrest
  Intervention:  
  Sponsor:   Australian and New Zealand Intensive Care Research Centre
  Not yet recruiting