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  • Conditions:   Insulin Resistance;   Healthy;   Obesity
    Interventions:   Drug: Phentolamine;   Other: Saline
    Sponsor:   Vanderbilt University Medical Center

  • Conditions:   Type1diabetes;   Hypoglycemia;   Hypoglycemia Unawareness
    Interventions:   Drug: Phentolamine;   Drug: Propranolol;   Drug: Placebo
    Sponsors:   University of Pennsylvania;   National Institutes of Health (NIH);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

  • Conditions:   Chronic Obstructive Pulmonary Disease;   Pulmonary Artery Hypertension;   Heart Failure;   Hypertension
    Interventions:   Other: Maximum Exercise Tests;   Drug: BH4, L-NMMA, Vitamin C, Vitamin E, α-Lipoic Acid and L-Ascorbate;   Drug: BQ-123;   Drug: Fexofenadine, Ranitidine;   Other: Angiotensin-II, Valsartan;   Drug: Acetylcholine, Sodium Nitroprusside, Angiotensin-II, Norepinephrine, Phentolamine;   Drug: BQ-123, MitoQ, BH4
    Sponsor:   Russell Richardson

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