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• A Study Of Ipatasertib in Combination With Atezolizumab and Paclitaxel as a Treatment for Participants With Locally Advanced or Metastatic Triple-Negative Breast Cancer.

  NCT04177108

  Condition:   Triple-Negative Breast Cancer
  Interventions:   Drug: Atezolizumab;   Drug: Ipatasertib;   Drug: Paclitaxel;   Drug: Placebo for Atezolizumab;   Drug: Placebo for Ipatasertib
  Sponsor:   Hoffmann-La Roche
  Recruiting
• A Study to Assess the Safety and Efficacy of a Single Dose of UBX0101 in Patients With Osteoarthritis of the Knee

  NCT04129944

  Condition:   Osteoarthritis, Knee
  Interventions:   Drug: UBX0101;   Other: Placebo
  Sponsor:   Unity Biotechnology, Inc.
  Recruiting
• Dexpramipexole Dose-Ranging Biomarker Study in Subjects With Eosinophilic Asthma

  NCT04046939

  Conditions:   Eosinophilic Asthma;   Asthma
  Interventions:   Drug: low-dose dexpramipexole;   Drug: mid-dose dexpramipexole;   Drug: high-dose dexpramipexole;   Drug: placebo oral tablet
  Sponsor:   Knopp Biosciences
  Recruiting
• A Study to Find Out How Safe Long-term Treatment With Fezolinetant is in Women With Hot Flashes Going Through Menopause

  NCT04003389

  Condition:   Hot Flashes
  Interventions:   Drug: fezolinetant;   Drug: placebo
  Sponsor:   Astellas Pharma Global Development, Inc.
  Recruiting
• A Study to Find Out if Fezolinetant Helps Reduce Moderate to Severe Hot Flashes in Women Going Through Menopause

  NCT04003155

  Condition:   Hot Flashes
  Interventions:   Drug: fezolinetant;   Drug: placebo
  Sponsor:   Astellas Pharma Global Development, Inc.
  Recruiting
• Study to Evaluate the Efficacy, Safety and Tolerability of Vibegron in Men With Overactive Bladder (OAB) Symptoms on Pharmacological Therapy for Benign Prostatic Hyperplasia (BPH)

  NCT03902080

  Condition:   Overactive Bladder
  Interventions:   Drug: Vibegron;   Drug: Placebo
  Sponsor:   Urovant Sciences GmbH
  Recruiting
• A Study of Baricitinib in Participants With Systemic Lupus Erythematosus (SLE)

  NCT03843125

  Condition:   Systemic Lupus Erythematosus
  Intervention:   Drug: Baricitinib
  Sponsors:   Eli Lilly and Company;   Incyte Corporation
  Recruiting
• Study Evaluating the Efficacy and Safety of Intranasal Administration of OPN-375 in Subjects With Chronic Sinusitis With or Without the Presence of Nasal Polyps

  NCT03781804

  Condition:   Chronic Sinusitis
  Intervention:   Drug: OPN-375
  Sponsor:   Optinose US Inc.
  Recruiting
• Efficacy, Safety, and Pharmacokinetic Profiles of REGN3500 Administered to Adult Patients With Moderate-to-Severe Atopic Dermatitis

  NCT03738423

  Condition:   Atopic Dermatitis
  Interventions:   Drug: REGN3500;   Drug: REGN3500-Matching Placebo
  Sponsors:   Regeneron Pharmaceuticals;   Sanofi
  Recruiting
• Safety and Efficacy Study of IFX-1 in add-on to Standard of Care in Granulomatosis With Polyangiitis (GPA) and Microscopic Polyangiitis (MPA)

  NCT03712345

  Conditions:   Granulomatosis With Polyangiitis (GPA);   Microscopic Polyangiitis (MPA)
  Interventions:   Drug: IFX-1;   Drug: Placebo
  Sponsors:   InflaRx GmbH;   Iqvia Pty Ltd
  Recruiting
• Blood Sample Collection to Evaluate Biomarkers in Subjects With Untreated Solid Tumors

  NCT03662204

  Conditions:   Breast Cancer;   Lung Cancer;   Colorectal Cancer;   Prostate Cancer;   Bladder Cancer;   Uterine Cancer;   Kidney Cancer;   Renal Pelvis Cancer;   Pancreatic Cancer;   Liver Cancer;   Stomach Cancer;   Ovarian Cancer;   Esophageal Cancer
  Intervention:   Other: Blood Sample Collection
  Sponsor:   Exact Sciences Corporation
  Recruiting
• A Study of Baricitinib in Participants With Systemic Lupus Erythematosus

  NCT03616964

  Condition:   Systemic Lupus Erythematosus
  Interventions:   Drug: Baricitinib;   Drug: Placebo
  Sponsors:   Eli Lilly and Company;   Incyte Corporation
  Recruiting
• Etokimab in Adult Patients With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)

  NCT03614923

  Condition:   Chronic Rhinosinusitis
  Interventions:   Biological: Etokimab;   Biological: Placebo
  Sponsor:   AnaptysBio, Inc.
  Recruiting
• SI-6603 (Condoliase) Study for Lumbar Disc Herniation (Discovery 6603 Study)

  NCT03607838

  Condition:   Lumbar Disc Herniation
  Interventions:   Drug: SI-6603;   Drug: Sham injection
  Sponsor:   Seikagaku Corporation
  Recruiting
• Long-term Extension Trial in Subjects With Atopic Dermatitis Who Participated in Previous Tralokinumab Trials - ECZTEND

  NCT03587805

  Condition:   Atopic Dermatitis
  Intervention:   Drug: Tralokinumab
  Sponsor:   LEO Pharma
  Recruiting
• Trial of IW-3718 for 8 Weeks in Patients With Persistent Gastroesophageal Reflux Disease (GERD) Receiving Proton Pump Inhibitors

  NCT03561883

  Condition:   Gastroesophageal Reflux Disease (GERD)
  Interventions:   Drug: IW-3718;   Drug: placebo
  Sponsor:   Ironwood Pharmaceuticals, Inc.
  Recruiting
• Open-Label Extension and Safety Study for Participants With Crohn's Disease Previously Enrolled in the Etrolizumab Phase III Study GA29144

  NCT02403323

  Condition:   Crohn Disease
  Intervention:   Drug: Etrolizumab
  Sponsor:   Hoffmann-La Roche
  Recruiting
• A Study to Assess Whether Etrolizumab is a Safe and Efficacious Treatment for Participants With Moderately to Severely Active Crohn's Disease

  NCT02394028

  Condition:   Crohn Disease
  Interventions:   Drug: Etrolizumab;   Drug: Placebo
  Sponsor:   Hoffmann-La Roche
  Recruiting
• Study for Participants With Ulcerative Colitis Previously Enrolled in Etrolizumab Phase II/III Studies

  NCT02118584

  Condition:   Ulcerative Colitis
  Intervention:   Drug: Etrolizumab
  Sponsor:   Hoffmann-La Roche
  Recruiting
• A Study Of PF-05212384 In Combination With Other Anti-Tumor Agents and in Combination With Cisplatin in Patients With Triple Negative Breast Cancer in an Expansion Arm (TNBC)

  NCT01920061

  Condition:   Neoplasm
  Interventions:   Drug: PF-05212384 (gedatolisib);   Drug: Docetaxel;   Drug: Cisplatin;   Drug: Dacomitinib
  Sponsor:   Pfizer
  Recruiting
• Efficacy and Safety of Nemolizumab in Subjects With Moderate-to-Severe Atopic Dermatitis

  NCT03985943

  Condition:   Moderate-to-Severe Atopic Dermatitis
  Interventions:   Drug: Placebo;   Drug: Nemolizumab
  Sponsor:   Galderma R&D
  Recruiting
• A Phase III Study of Efficacy and Safety of Ligelizumab in the Treatment of CSU in Adolescents and Adults Inadequately Controlled With H1-antihistamines.

  NCT03580356

  Condition:   Chronic Spontaneous Urticaria
  Interventions:   Biological: Ligelizumab;   Biological: Omalizumab;   Other: Placebo
  Sponsor:   Novartis Pharmaceuticals
  Recruiting
• Study of Patients Receiving DUPIXENT® for Atopic Dermatitis (AD)

  NCT03428646

  Condition:   Dermatitis, Atopic
  Intervention:   Drug: Dupilumab
  Sponsors:   Regeneron Pharmaceuticals;   Sanofi
  Recruiting