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• Study Evaluating Pharmacokinetics and Mass Balance of [14C]-CTP-543 in Healthy Adult Male Volunteers

  NCT04092712

  Condition:   Healthy Volunteers
  Intervention:   Drug: [14C]-CTP-543
  Sponsors:   Concert Pharmaceuticals;   Celerion
  Completed
• Single and Multiple Ascending Dose, First-in- Human Study in Healthy Subjects

  NCT04044339

  Condition:   Healthy
  Interventions:   Drug: TD-5202;   Drug: Placebo
  Sponsor:   Theravance Biopharma
  Recruiting
• Comparison of a Non-linear Analysis of Balance During the mBESS to the Sway Balance Application

  NCT03994952

  Condition:   Healthy Volunteers
  Interventions:   Device: Sway Balance Application;   Device: Balance Tracking Systems
  Sponsor:   University of Nebraska
  Recruiting
• Alcohol Myopia, Objectification, and Sexual Assault

  NCT03956238

  Condition:   Alcoholic Intoxication
  Interventions:   Behavioral: Alcohol intoxication;   Behavioral: Objectification
  Sponsors:   University of Nebraska Lincoln;   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
  Recruiting
• Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MRG-110 Following Intradermal Injection in Healthy Volunteers

  NCT03603431

  Condition:   Healthy Volunteer
  Interventions:   Drug: MRG-110;   Drug: Placebo
  Sponsor:   miRagen Therapeutics, Inc.
  Completed
• Resistance Exercise and Protein During Weight Loss

  NCT03600311

  Conditions:   Weight Loss;   Starvation
  Interventions:   Other: Caloric Restriction;   Dietary Supplement: Post-Exercise Protein;   Other: Energy Balance;   Dietary Supplement: Post-Exercise Carbohydrate;   Dietary Supplement: Calcium and Vitamin D
  Sponsor:   University of Nebraska Lincoln
  Completed
• Mother and Child Health Outcomes After Maternal Bariatric Surgery

  NCT03297307

  Condition:   Weight Loss
  Intervention:   Behavioral: Presurgical Counseling
  Sponsor:   University of Nebraska
  Recruiting
• Finances First: A Health Intervention in Low Income Single Mother Households

  NCT03035240

  Condition:   Financial Stress
  Intervention:   Behavioral: Financial Education
  Sponsor:   Creighton University
  Recruiting
• Initiation of a Deceased Donor Uterine Transplantation Program at the University of Nebraska Medical Center

  NCT02409147

  Condition:   Uterus Transplant
  Intervention:   Procedure: Uterine Transplant
  Sponsor:   University of Nebraska
  Withdrawn
• A Phase 1 Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TBA-354 in Healthy Adult Subjects

  NCT02288481

  Condition:   Tuberculosis
  Interventions:   Drug: TBA-354;   Other: Placebo
  Sponsor:   Global Alliance for TB Drug Development
  Completed
• PK Interaction Between Rifapentine or Rifampicin and a Single Dose of TMC207 in Healthy Subjects (TMC207-CL002)

  NCT02216331

  Condition:   Tuberculosis
  Interventions:   Drug: TMC207;   Drug: rifapentine;   Drug: rifampicin
  Sponsor:   Global Alliance for TB Drug Development
  Completed
• Food Effect Study on the Bioavailability and PK of PA-824 Tablets in Healthy Adult Subjects (CL-009)

  NCT01830439

  Condition:   Tuberculosis
  Interventions:   Drug: PA-824 200mg;   Drug: PA-824 50mg
  Sponsor:   Global Alliance for TB Drug Development
  Completed
• Evaluation of the Pharmacokinetic Interaction Between PA-824 and Midazolam

  NCT01768273

  Condition:   Tuberculosis
  Interventions:   Drug: Midazolam;   Drug: PA-824
  Sponsor:   Global Alliance for TB Drug Development
  Completed
• Effects of Escitalopram on Autonomic Reactivity in Post Traumatic Stress Disorder

  NCT01271244

  Condition:   PTSD
  Intervention:   Drug: Escitalopram
  Sponsors:   VA Nebraska Western Iowa Health Care System;   Forest Laboratories
  Completed
• Uphill Walking as Exercise for COPD Patients

  NCT04026529

  Condition:   Chronic Obstructive Pulmonary Disease
  Intervention:   Other: walking on incline or walking at increasing speed
  Sponsors:   VA Office of Research and Development;   University of Nebraska, Omaha
  Not yet recruiting
• A Study to Assess Tobacco-related Biomarkers of Exposure in Smokers Using myBlu E-cigarettes

  NCT04019626

  Condition:   Healthy Volunteers
  Interventions:   Other: Continue-smoking;   Other: myblu Tobacco Chill 2.5%;   Other: myblu Tobacco Chill 4.0%;   Other: myblu Honeymoon 2.5%;   Other: myblu Honeymoon 4.0%
  Sponsor:   Fontem Ventures BV
  Recruiting
• Bictegravir/Emtricitabine/Tenofovir Alafenamide (B/F/TAF) in HIV-1 Infected Patients With Active Illicit Substance usE

  NCT03998176

  Condition:   HIV-1-infection
  Intervention:   Drug: Bictegravir/emtricitabine/tenofovir alafenamide
  Sponsors:   University of Nebraska;   Gilead Sciences
  Not yet recruiting
• Evaluation of the Spry Belt for Improving Bone Quality

  NCT03986203

  Condition:   Osteopenia
  Intervention:   Device: Spry Belt
  Sponsors:   Theranova, L.L.C.;   National Institute on Aging (NIA);   University of Nebraska
  Recruiting
• A Study of Durvalumab Plus Tremelimumab With Chemotherapy in Untreated ES-SCLC

  NCT03963414

  Condition:   Small Cell Lung Carcinoma
  Interventions:   Combination Product: Durvalumab + Tremelimumab in combination with carboplatin and etoposide;   Combination Product: Durvalumab in combination with carboplatin and etoposide
  Sponsors:   Vinicius Ernani;   AstraZeneca
  Not yet recruiting
• A Pilot Study to Compare the Pharmacokinetics (PK) of Single Subcutaneous (SC) Injections of Vedolizumab Administered in Prefilled Syringe (PFS) Versus (vs) Prefilled Syringe in Autoinjector (PFS+AI) in Healthy Participants

  NCT03961295

  Condition:   Healthy Volunteers
  Intervention:   Drug: Vedolizumab SC
  Sponsor:   Takeda
  Completed
• Impact of Evolocumab in Cardiac Transplant Patients With CAV

  NCT03944577

  Condition:   Heart Transplant
  Intervention:   Drug: Evolocumab (Repatha)
  Sponsors:   University of Nebraska;   Amgen
  Recruiting
• Impact of Blueberry Consumption on Gastrointestinal Health

  NCT03934177

  Conditions:   Obesity;   Circadian Dysregulation
  Interventions:   Dietary Supplement: Blueberry powder;   Dietary Supplement: Placebo powder
  Sponsors:   University of Nebraska Lincoln;   Rush University Medical Center
  Enrolling by invitation
• ONC 201 Maintenance Therapy in Acute Myeloid Leukemia and Myelodysplastic Syndrome After Stem Cell Transplant

  NCT03932643

  Conditions:   Acute Myeloid Leukemia;   Myelodysplastic Syndromes
  Intervention:   Drug: ONC201
  Sponsor:   Vijaya Bhatt
  Recruiting
• Restoring Cognitive Control in Acute Nicotine Withdrawal

  NCT03887429

  Condition:   Impulse Control Disorders
  Interventions:   Drug: SXC-2023;   Drug: Placebos
  Sponsors:   Promentis Pharmaceuticals, Inc.;   Baylor College of Medicine;   Celerion
  Completed
• Restoration of Spectral Resolution With Hearing-aid Amplification

  NCT03850678

  Condition:   Hearing Loss
  Intervention:   Device: Hearing Aid
  Sponsors:   University of Nebraska Lincoln;   National Institute on Deafness and Other Communication Disorders (NIDCD)
  Recruiting
• Biomarker Assessments of Leukine During Treatment of Parkinson's Disease

  NCT03790670

  Condition:   Parkinson Disease
  Intervention:   Drug: sargramostim
  Sponsor:   University of Nebraska
  Active, not recruiting
• Understanding the Post-Surgical Non-Small Cell Lung Cancer Patient's Symptom Experience

  NCT03724331

  Conditions:   Fatigue;   Self Efficacy;   Quality of Life;   Physical Activity;   Lung Cancer;   Non-Small Cell Lung Cancer
  Interventions:   Behavioral: Light Physical Activity 1;   Behavioral: Light Physical Activity 2;   Behavioral: Support Education Activity
  Sponsors:   University of Nebraska;   Spectrum Health Hospitals;   Ingham Regional Medical Center;   Sparrow Clinical Research Institute;   Munson Medical Center
  Recruiting
• Effect of Vitamin D Supplementation on Balance in CKD

  NCT03710161

  Conditions:   Renal Insufficiency, Chronic;   Kidney Failure, Chronic
  Intervention:   Drug: Vitamin D
  Sponsor:   University of Nebraska
  Recruiting
• Increasing Caregiver and Patient Engagement Through PHR Use

  NCT03659565

  Condition:   Cardiovascular Diseases
  Interventions:   Behavioral: Enhanced Pre-Visit Consultation;   Behavioral: Usual Care Control
  Sponsor:   University of Nebraska
  Recruiting
• Targeted Transcranial Magnetic Stimulation to Improve Hippocampal-dependent Declarative Memory Abilities

  NCT03574207

  Conditions:   Mild Cognitive Impairment;   Memory Loss
  Intervention:   Device: Transcranial magnetic stimulation
  Sponsors:   University of Nebraska;   National Institute of General Medical Sciences (NIGMS)
  Recruiting
• Anti-PD-1 Antibody With HD IL-2 in Metastatic Melanoma

  NCT03476174

  Condition:   Melanoma
  Interventions:   Drug: Pembrolizumab;   Drug: Interleukin-2
  Sponsors:   Ralph Hauke;   Nebraska Cancer Specialists; Midwest Cancer Center-Legacy;   Prometheus Laboratories
  Recruiting
• Reducing Distress and Depressive-symptoms in Rural Women

  NCT03465813

  Conditions:   Breast Cancer;   Psychological Adjustment
  Intervention:   Behavioral: CaringGuidance After Breast Cancer Diagnosis
  Sponsors:   University of Nebraska;   University of Kansas Medical Center
  Completed
• The Patients' Experience After Stem Cell Transplant

  NCT03454568

  Condition:   Stem Cell Transplant Complications
  Intervention:  
  Sponsor:   University of Nebraska
  Recruiting
• Facilitating Oncology Patient-Clinician Communication Via E-health Innovations

  NCT03442127

  Condition:   Breast Cancer
  Intervention:   Behavioral: CaringGuidance™ After Breast Cancer Diagnosis
  Sponsor:   University of Nebraska
  Recruiting
• Treatment of Rheumatoid Arthritis With Methotrexate: Predictors of Response

  NCT03414502

  Condition:   Rheumatoid Arthritis
  Intervention:   Drug: Methotrexate
  Sponsor:   University of Nebraska
  Recruiting
• Safety Study of BMX-001 (Radio-protector) in Patients With Newly Diagnosed Anal Cancer

  NCT03386500

  Conditions:   Anal Cancer, Squamous Cell Carcinoma;   Radiation Exposure
  Intervention:   Drug: BMX-001
  Sponsors:   Chi Lin, MD;   BioMimetix JV, LLC;   University of Nebraska
  Recruiting
• Minocycline for Treatment of Posttraumatic Stress Disorder in Veterans

  NCT03340350

  Condition:   PTSD
  Intervention:   Drug: Minocycline
  Sponsors:   Sriram Ramaswamy;   Creighton University
  Completed
• Engaging Rural Men With Mobile Technologies for Weight Loss

  NCT03329079

  Condition:   Weight Loss
  Interventions:   Behavioral: Mobile Technology Plus;   Behavioral: Mobile Technology
  Sponsors:   University of Nebraska;   Northeast Nebraska Public Health Department
  Active, not recruiting
• Preventing Diabetes With Digital Health and Coaching

  NCT03312764

  Condition:   PreDiabetes
  Interventions:   Behavioral: Online diabetes prevention program;   Behavioral: Standard Care
  Sponsors:   Omada Health, Inc.;   University of Nebraska;   Wake Forest University Health Sciences
  Active, not recruiting
• Impact of Oral Hygiene Gels on Peri-implant Mucositis

  NCT03243591

  Condition:   Mucositis
  Interventions:   Other: Livionex gel;   Other: Aquafresh gel
  Sponsor:   University of Nebraska
  Completed
• Integrating Geriatric Assessment and Genetic Profiling to Personalize Therapy Selection in Older Adults With Acute Myeloid Leukemia

  NCT03226418

  Conditions:   Adult Acute Myeloid Leukemia;   Secondary Acute Myeloid Leukemia;   Therapy-Related Acute Myeloid Leukemia
  Interventions:   Drug: Cytarabine;   Drug: Decitabine;   Drug: Idarubicin;   Other: Laboratory Biomarker Analysis;   Drug: Liposome-encapsulated Daunorubicin-Cytarabine;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration;   Drug: Azacitidine;   Drug: Venetoclax;   Drug: glasdegib
  Sponsors:   University of Nebraska;   National Cancer Institute (NCI)
  Recruiting
• Effects of Carbohydrate in Diet and Supplements on the Gastrointestinal Tolerability of LIK066

  NCT03198767

  Condition:   Obesity
  Interventions:   Drug: LIK066;   Dietary Supplement: Carbohydrate 50%;   Dietary Supplement: Carbohydrate 25%;   Dietary Supplement: Carbohydrate 8%;   Dietary Supplement: Carbohydrate 0%;   Dietary Supplement: Psyllium;   Dietary Supplement: Calcium carbonate
  Sponsor:   Novartis Pharmaceuticals
  Completed
• Early Rheumatoid Arthritis Lung Disease Study

  NCT03192267

  Condition:   Rheumatoid Arthritis
  Intervention:  
  Sponsor:   University of Nebraska
  Recruiting
• Intensive Referral to Reduce Smoking in Probationers

  NCT03042650

  Conditions:   Smoking Cessation;   Substance Use Disorder
  Interventions:   Behavioral: Intensive Referral Intervention Group;   Behavioral: Standard Practice Facilitated Group
  Sponsor:   University of Nebraska
  Active, not recruiting
• Assessing Home Food Environment and Diabetes Self-management Among Adult Type 2 Diabetes Patients

  NCT03039569

  Condition:   Diabetes Mellitus, Type 2
  Intervention:   Behavioral: Text messaging
  Sponsors:   University of Nebraska Lincoln;   The Methodist Hospital System
  Completed
• TGR-1202 and Ibrutinib in Treating Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma

  NCT02874404

  Conditions:   Recurrent Diffuse Large B-Cell Lymphoma;   Refractory Diffuse Large B-Cell Lymphoma
  Interventions:   Drug: Ibrutinib;   Other: Laboratory Biomarker Analysis;   Drug: PI3K-delta Inhibitor TGR-1202
  Sponsors:   Matthew Lunning, DO;   National Cancer Institute (NCI)
  Completed
• Bevacizumab and Ascorbic Acid in Patients Treating With Recurrent High Grade Glioma

  NCT02833701

  Conditions:   Glioblastoma;   Glioma
  Interventions:   Dietary Supplement: Ascorbic Acid;   Biological: Bevacizumab;   Other: Laboratory Biomarker Analysis;   Other: Quality-of-Life Assessment
  Sponsors:   University of Nebraska;   National Cancer Institute (NCI)
  Terminated
• Electrophysiological Biomarkers of Chemotherapy-related Cognitive Impairment and Recovery

  NCT02767388

  Conditions:   Myelodysplastic Syndrome;   Effects of Chemotherapy;   Mild Cognitive Impairment;   Multiple Myeloma;   Non-hodgkin Lymphoma;   Chronic Lymphocytic Leukemia;   Acute Lymphoid Leukemia;   Chronic Myeloid Leukemia;   Acute Myeloid Leukemia
  Intervention:  
  Sponsor:   University of Nebraska
  Completed
• Promoting Gastrointestinal Health and Reducing Subclinical Inflammation in Obese Individuals

  NCT02602496

  Conditions:   Obesity;   Overweight
  Interventions:   Other: Fruits and Vegetables;   Other: Whole Grain;   Other: Control
  Sponsor:   University of Nebraska Lincoln
  Completed
• Cholecalciferol in Treating Patients With Newly Diagnosed Non-Hodgkin Lymphoma or Chronic Lymphocytic Leukemia With Vitamin D Deficiency

  NCT02553447

  Conditions:   Chronic Lymphocytic Leukemia;   Non-Hodgkin Lymphoma;   Untreated Chronic Lymphocytic Leukemia;   Vitamin D Deficiency
  Interventions:   Dietary Supplement: Cholecalciferol;   Other: Laboratory Biomarker Analysis
  Sponsors:   University of Nebraska;   National Cancer Institute (NCI)
  Recruiting
• Safety Study of DWP-450 (Botulinum Toxin, Type a) to Treat Glabellar Lines - EV-006

  NCT02428608

  Condition:   Glabellar Frown Lines
  Intervention:   Biological: DWP-450 (Botulinum purified neurotoxin, Type A)
  Sponsors:   Evolus, Inc.;   PPD
  Completed
• Phase 1 Study of ACE-083 in Healthy Subjects

  NCT02257489

  Condition:   Musculoskeletal Diseases
  Intervention:   Drug: ACE-083
  Sponsor:   Acceleron Pharma, Inc.
  Completed
• A SMART Design to Improve Sleep Disturbance in Adolescents With Neurodevelopmental Disorders

  NCT03730194

  Conditions:   Autism Spectrum Disorder;   Attention Deficit Hyperactivity Disorder;   Sleep Disturbance
  Interventions:   Dietary Supplement: Melatonin;   Behavioral: Bedtime Bank
  Sponsors:   University of Nebraska;   National Institute of Nursing Research (NINR)
  Recruiting
• Measurement of Beta Cell Death in Individuals With Cystic Fibrosis

  NCT03713437

  Condition:   Cystic Fibrosis-related Diabetes
  Intervention:   Diagnostic Test: Measurement of differentially methylated insulin DNA
  Sponsors:   University of Nebraska;   Cystic Fibrosis Foundation
  Recruiting
• A Research Study of NNC0165-1562 and Semaglutide in People Who Are Overweight or Obese

  NCT03574584

  Conditions:   Metabolism and Nutrition Disorders;   Overweight or Obesity
  Interventions:   Drug: NNC0165-1562;   Drug: Semaglutide;   Drug: Placebo (NNC0165-1562)
  Sponsor:   Novo Nordisk A/S
  Completed
• Effects of Octacosanol During Taekwondo Training

  NCT03557476

  Conditions:   Oxidative Stress;   Dyslipidemias
  Interventions:   Dietary Supplement: Octacosanol;   Dietary Supplement: Placebo
  Sponsor:   University of Nebraska, Omaha
  Completed
• Mobility Exercises for Gait (MEG Neuroplasticity Project)

  NCT03555708

  Condition:   Cerebral Palsy
  Intervention:   Other: Physical Therapy
  Sponsor:   University of Nebraska
  Recruiting
• Treatment of Vitamin D Deficiency in Intestinal Rehabilitation Clinic Patients With a Portable Ultraviolet B Lamp

  NCT01930539

  Conditions:   Vitamin D Deficiency;   Short Bowel Syndrome
  Intervention:   Device: Ultraviolet B lamp
  Sponsor:   University of Nebraska
  Completed
• Resurgence as Choice: Basic and Clinical Studies

  NCT03423940

  Conditions:   Increasing Functional Communicative Behavior;   Decreasing Destructive Behavior;   Analysis of Treatment Dosage;   Empirically Determined Reinforcement Schedule Thinning
  Interventions:   Behavioral: Functional communication training;   Behavioral: RaC-enhanced functional communication training
  Sponsors:   University of Nebraska;   Utah State University
  Recruiting
• Feasibility of a Touch Screen Computer Based Breast-feeding Educational Support Program

  NCT03308058

  Condition:   Pregnancy Related
  Intervention:   Behavioral: Breastfeeding computer education
  Sponsor:   University of Nebraska
  Completed
• Assessment of Eloquent Function in Brain Tumor Patients

  NCT01535430

  Conditions:   Primary Brain Tumor;   Metastatic Brain Tumor
  Intervention:  
  Sponsor:   University of Nebraska
  Recruiting
• Diaphragmatic Breathing Retraining in Heart Failure Patients: Health-Behavior Related Outcomes

  NCT01478932

  Condition:   Dyspnea
  Intervention:   Behavioral: diaphragmatic breathing retraining
  Sponsors:   University of Nebraska;   National Institute of Nursing Research (NINR)
  Terminated
• Forteo Trial on Idiopathic Osteoporosis in Premenopausal Women

  NCT01440803

  Condition:   Adult Idiopathic Generalized Osteoporosis
  Interventions:   Drug: Teriparatide;   Drug: Saline Placebo
  Sponsors:   Columbia University;   Creighton University;   Food and Drug Administration (FDA)
  Completed
• Panitumumab, Combination Chemotherapy, and Radiation Therapy Before Surgery in Treating Patients With Advanced Esophageal or Gastroesophageal Junction Cancer

  NCT01307956

  Conditions:   Adenocarcinoma of the Gastroesophageal Junction;   Esophageal Adenocarcinoma;   Stage IIA Esophageal Cancer;   Stage IIB Esophageal Cancer
  Interventions:   Drug: Fluorouracil;   Other: Laboratory Biomarker Analysis;   Drug: Leucovorin Calcium;   Drug: Oxaliplatin;   Biological: Panitumumab;   Other: Pharmacological Study;   Radiation: Radiation Therapy;   Procedure: Therapeutic Conventional Surgery
  Sponsors:   University of Nebraska;   National Cancer Institute (NCI)
  Terminated
• Treatment of Severe Destructive Behavior: FCT Versus Wait-List Control

  NCT02483572

  Conditions:   Aggression;   Self-Injurious Behavior
  Intervention:   Behavioral: Functional Communication Training
  Sponsor:   University of Nebraska
  Terminated
• Sulfation of Bile Acids as a Biomarker for Hepatobiliary Diseases

  NCT01200082

  Condition:   Hepatobiliary Diseases
  Intervention:  
  Sponsor:   University of Nebraska
  Recruiting
• Aqueous Humor Dynamics and Brimonidine

  NCT01144494

  Condition:   Intraocular Pressure
  Interventions:   Drug: Brimonidine;   Drug: Artificial tears
  Sponsor:   University of Nebraska
  Completed
• Stereotactic Radiation Therapy, Nelfinavir Mesylate, Gemcitabine Hydrochloride, Leucovorin Calcium, and Fluorouracil in Treating Patients With Locally Advanced Pancreatic Cancer

  NCT01068327

  Conditions:   Adenocarcinoma of the Pancreas;   Stage III Pancreatic Cancer
  Interventions:   Drug: gemcitabine hydrochloride;   Drug: leucovorin calcium;   Drug: fluorouracil;   Drug: nelfinavir mesylate;   Radiation: stereotactic body radiation therapy;   Radiation: hypofractionated radiation therapy;   Procedure: therapeutic conventional surgery
  Sponsors:   University of Nebraska;   National Cancer Institute (NCI)
  Completed
• Clinical Trial of Vitamin D3 to Reduce Cancer Risk in Postmenopausal Women

  NCT01052051

  Condition:   Cancer
  Interventions:   Dietary Supplement: Vitamin D3;   Dietary Supplement: Calcium carbonate
  Sponsors:   Creighton University;   National Institutes of Health (NIH);   National Cancer Institute (NCI)
  Completed
• Topotecan Hydrochloride and Doxorubicin Hydrochloride in Treating Patients With Relapsed or Refractory Small Cell Lung Cancer

  NCT00856037

  Condition:   Recurrent Small Cell Lung Carcinoma
  Interventions:   Drug: Doxorubicin Hydrochloride;   Other: Laboratory Biomarker Analysis;   Other: Quality-of-Life Assessment;   Drug: Topotecan Hydrochloride
  Sponsors:   University of Nebraska;   National Cancer Institute (NCI)
  Completed
• Effects of Atypical Antipsychotics on Brain Function in Children and Teens With Conduct Disorders

  NCT01867398

  Conditions:   Conduct Disorder;   fMRI
  Intervention:  
  Sponsors:   National Institute of Mental Health (NIMH);   Boys Town Research Hospital
  Terminated
• Distribution of Topical Nasal Medication Within the Nasal Cavity and Sinuses by Radiographic Comparison

  NCT00626366

  Condition:   Chronic Sinusitis
  Interventions:   Radiation: Sinus CT Scan;   Drug: Omnipaque 240 Contrast Solution;   Drug: Omnipaque 240 mg I/mL
  Sponsor:   University of Nebraska
  Completed
• CT Scans in Screening for Lung Cancer in Current and Former Smokers

  NCT00625690

  Condition:   Lung Cancer
  Interventions:   Other: questionnaire administration;   Procedure: computed tomography;   Procedure: evaluation of cancer risk factors;   Procedure: study of high risk factors
  Sponsors:   University of Nebraska;   National Cancer Institute (NCI)
  Completed
• Triple III Comparison of Leflunomide Alone Versus Two DMARD Combinations in the Treatment of Rheumatoid Arthritis

  NCT00579878

  Condition:   Rheumatoid Arthritis
  Interventions:   Drug: Leflunomide;   Drug: Methotrexate-Sulfasalazine-Hydroxychloroquine;   Drug: Leflunomide-Sulfasalazine-Hydroxychloroquine
  Sponsor:   University of Nebraska
  Completed
• Role of Apathy in the Effectiveness of Weight Loss Interventions

  NCT00548652

  Conditions:   Obesity;   Apathy
  Interventions:   Behavioral: MOVE;   Behavioral: medical crisis councelling;   Drug: methyphenidate
  Sponsor:   VA Nebraska Western Iowa Health Care System
  Completed
• Validity of Physical Activity Questionnaires in Persons Pursuing Bariatric Surgery

  NCT03981978

  Conditions:   Bariatric Surgery Candidate;   Obesity
  Intervention:   Behavioral: Physical Activity
  Sponsor:   University of Nebraska
  Not yet recruiting
• Assessment of and Treatment Applied to Food Addiction in a Rural Healthy Behaviors Clinic

  NCT03431831

  Condition:   Obesity
  Interventions:   Behavioral: Intervention Control;   Behavioral: Counselling;   Drug: Contrave;   Drug: Contrave and Counseling
  Sponsor:   University of Nebraska
  Active, not recruiting
• Hand-sewn and Linear-stapled Roux-en-Y Gastric Bypass: Outcomes

  NCT03199352

  Condition:   Roux-en-y Anastomosis Site
  Interventions:   Other: RYGB hand-sewn;   Other: RYGB linear-staple
  Sponsor:   University of Nebraska
  Enrolling by invitation
• CALLiNGS Protocol: Care Across Locations Longitudinally in Navigation of Goals and Symptoms

  NCT03999957

  Condition:   Palliative Care
  Intervention:   Other: Telehealth web conferencing
  Sponsor:   University of Nebraska
  Recruiting
• Effect of Vascular Endothelial Growth Factor Blockers on Aqueous Humor Dynamics

  NCT01994174

  Condition:   Macular Disease
  Intervention:  
  Sponsor:   University of Nebraska
  Recruiting
• Followup of Glenoid Fix Utilizing Auto Bone Graft in Shoulder Replacement

  NCT00670852

  Condition:   Arthritis
  Intervention:   Procedure: X-rays and CT scan
  Sponsor:   University of Nebraska
  Completed
• Bupropion in the Treatment of Methamphetamine Dependence

  NCT00572234

  Condition:   Methamphetamine Use Disorder
  Intervention:   Drug: bupropion SR
  Sponsor:   University of Nebraska
  Completed
• First-Sight Refractive Error Correction: Direct Comparison to Autorefraction Results in Children 7 to 18 Years of Age

  NCT01365884

  Condition:   Refractive Error
  Intervention:  
  Sponsor:   University of Nebraska
  Terminated
• Safety, Tolerability, PK and Antitumor Activity of KPG-121 Plus Enzalutamide in mCRPC Patients

  NCT03569280

  Condition:   Metastatic Castration-Resistant Prostate Cancer
  Intervention:   Combination Product: KPG-121 dose escalation + Enzalutamide
  Sponsors:   Kangpu Biopharmaceuticals, Ltd.;   Accelovance
  Recruiting
• A Study to Compare the Pharmacokinetics (PK) of Single Subcutaneous (SC) Injections of Vedolizumab Administered in Prefilled Syringe (PFS) Versus (vs) Prefilled Syringe in Autoinjector (PFS+AI) in Healthy Participants

  NCT03961308

  Condition:   Healthy Volunteers
  Intervention:   Drug: Vedolizumab SC
  Sponsor:   Takeda
  Completed
• Cyclophosphamide, Paclitaxel, and Trastuzumab in Treating Patients With Stage I-II HER2/Neu Positive Breast Cancer After Surgery

  NCT02654119

  Conditions:   HER2 Positive Breast Carcinoma;   Stage I Breast Cancer AJCC v7;   Stage IA Breast Cancer AJCC v7;   Stage IB Breast Cancer AJCC v7;   Stage II Breast Cancer AJCC v6 and v7;   Stage IIA Breast Cancer AJCC v6 and v7;   Stage IIB Breast Cancer AJCC v6 and v7
  Interventions:   Drug: Cyclophosphamide;   Other: Laboratory Biomarker Analysis;   Drug: Paclitaxel;   Biological: Trastuzumab
  Sponsors:   University of Nebraska;   National Cancer Institute (NCI)
  Active, not recruiting
• An Ascending Dose Comparison of MVT-100 to Definity in Healthy Volunteers

  NCT03882359

  Condition:   Heart Diseases
  Interventions:   Diagnostic Test: Echocardiogram;   Drug: MVT-100;   Drug: Definity
  Sponsors:   Microvascular Therapeutics, LLC;   National Heart, Lung, and Blood Institute (NHLBI);   University of Nebraska
  Recruiting
• Trial of Atezolizumab Plus Chemotherapy After Progression on PD-1 or PD-L1 in Cisplatin-ineligible Patients With Advanced Urothelial Carcinoma

  NCT03737123

  Condition:   Urothelial Carcinoma
  Interventions:   Drug: Carboplatin;   Drug: Gemcitabine;   Drug: Atezolizumab;   Drug: Docetaxel
  Sponsors:   Nabil Adra;   Genentech, Inc.;   Indiana University School of Medicine
  Recruiting
• Docetaxel and Capecitabine With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck

  NCT02524275

  Condition:   Head and Neck Squamous Cell Carcinoma
  Interventions:   Drug: Capecitabine;   Drug: Docetaxel;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration
  Sponsor:   University of Nebraska
  Recruiting
• Alternative Dosing Schedule of Palbociclib in Metastatic Hormone Receptor Positive Breast Cancer

  NCT03007979

  Conditions:   Breast Cancer;   Breast Carcinoma;   Cancer of Breast;   Malignant Tumor of Breast
  Interventions:   Drug: Palbociclib;   Drug: Letrozole;   Drug: Fulvestrant;   Procedure: Optional research biopsy;   Drug: Goserelin;   Procedure: Research blood draw;   Procedure: Circulating tumor cell blood draw;   Procedure: Tumor biopsy (optional)
  Sponsors:   Washington University School of Medicine;   Pfizer
  Recruiting
• Safety, Tolerability, and Immunogenicity of Zika Vaccine mRNA-1893 in Healthy Flavivirus Seropositive and Seronegative Adults

  NCT04064905

  Condition:   Zika Virus
  Interventions:   Biological: mRNA-1893;   Other: Placebo
  Sponsors:   ModernaTX, Inc.;   Biomedical Advanced Research and Development Authority
  Recruiting
• 12 Weeks of Resistance Band Exercise Impacts on Metabolic Syndrome Progression in Postmenopausal Women

  NCT04014686

  Conditions:   Metabolic Syndrome;   Dyslipidemias;   Insulin Resistance;   Hypertension
  Interventions:   Other: No exercise intervention group;   Behavioral: Resistance band exercise intervention group
  Sponsor:   Pusan National University
  Completed
• Study on Physical Activity's Relationship With Cancer and Cognition

  NCT03980626

  Conditions:   Breast Cancer;   Breast Neoplasm Female
  Intervention:   Behavioral: Walking
  Sponsor:   University of Nebraska
  Recruiting
• 12 Weeks of Resistance Band Exercise Impacts on Adiposity, Hormones, and Blood Pressure in Postmenopausal Women

  NCT03919201

  Conditions:   Hypertension;   Hormone Disturbance;   Adiposity
  Interventions:   Other: Resistance band exercise intervention;   Other: No exercise intervention group
  Sponsor:   Pusan National University
  Completed
• Clinical Evaluation of the "NICU Clinical Decision Support Dashboard" - CHMCO

  NCT03673566

  Conditions:   Preterm Birth;   Low; Birthweight, Extremely (999 Grams or Less);   Neonatal Infection;   Satisfaction;   Stress;   Chronic Lung Disease;   Growth Acceleration;   Adverse Event
  Intervention:   Device: NICU Dashboard
  Sponsors:   Philips Healthcare;   Children's Hospital and Medical Center, Omaha, Nebraska
  Recruiting
• Impact of Custom Assistive and Adaptive Technology in Rehabilitation

  NCT03567239

  Conditions:   Disability Physical;   Brain Injuries;   Stroke;   Spinal Cord Injuries;   Multiple Sclerosis;   Paralysis
  Intervention:   Device: Using adaptive device.
  Sponsor:   Madonna Rehabilitation Hospital
  Recruiting
• Evaluation of Systemic Exposure to VP-102 in Subjects With Molluscum Contagiosum.

  NCT03186378

  Condition:   Molluscum Contagiosum
  Intervention:   Combination Product: VP-102 with applicator
  Sponsors:   Verrica Pharmaceuticals Inc.;   Paidion Research, Inc.;   Database Integrations, Inc.;   Cato Research;   Instat services
  Completed
• Specialized Substance Abuse Supervision (SSAS) Versus Non-SSAS Recidivism Rates Among Nebraska Felony Drug Offenders

  NCT00690352

  Conditions:   Substance-related Disorders;   Alcohol-related Disorders
  Intervention:   Behavioral: Specialized Substance Abuse Supervision (SSAS)
  Sponsor:   University of Nebraska
  Completed
• A Study of Tucatinib vs. Placebo in Combination With Ado-trastuzumab Emtansine (T-DM1) for Patients With Advanced or Metastatic HER2+ Breast Cancer

  NCT03975647

  Condition:   HER2-positive Breast Cancer
  Interventions:   Drug: tucatinib;   Drug: placebo;   Drug: T-DM1
  Sponsor:   Seattle Genetics, Inc.
  Recruiting
• Self-Management App for Patients With Left-Ventricular Assist Devices

  NCT03049748

  Condition:   Heart Failure
  Interventions:   Device: Mobile phone app (VAD Care App);   Other: Usual LVAD Care
  Sponsors:   University of Michigan;   Washington University School of Medicine;   National Institute of Nursing Research (NINR)
  Completed
• Doxepin Hydrochloride in Treating Esophageal Pain in Patients With Thoracic Cancer Receiving Radiation Therapy to the Thorax With or Without Chemotherapy

  NCT02062632

  Conditions:   Esophageal Carcinoma;   Hypopharyngeal Carcinoma;   Laryngeal Carcinoma;   Lymphoma;   Mesothelioma;   Metastatic Malignant Neoplasm in the Lung;   Metastatic Malignant Neoplasm in the Pleura;   Metastatic Malignant Neoplasm in the Spinal Cord;   Non-Small Cell Lung Carcinoma;   Sarcoma;   Small Cell Lung Carcinoma;   Thymic Carcinoma;   Thymoma;   Thyroid Gland Carcinoma
  Interventions:   Drug: Doxepin Hydrochloride;   Other: Placebo;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration
  Sponsors:   Mayo Clinic;   National Cancer Institute (NCI)
  Terminated
• Venetoclax in Treating Participants With Recurrent or Refractory Mature T-Cell Lymphoma

  NCT03534180

  Conditions:   Recurrent Mature T- and NK-Cell Non-Hodgkin Lymphoma;   Refractory Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma
  Interventions:   Other: Laboratory Biomarker Analysis;   Drug: Venetoclax
  Sponsors:   City of Hope Medical Center;   National Cancer Institute (NCI)
  Recruiting
• High Dose IL 2 and Entinostat in RCC

  NCT03501381

  Condition:   Renal Cell Carcinoma
  Interventions:   Drug: Entinostat;   Drug: Interleukin-2
  Sponsors:   Roberto Pili;   Indiana University Melvin and Bren Simon Cancer Center;   Prometheus Laboratories;   Syndax Pharmaceuticals
  Recruiting
• Additional Post Hoc Analysis and Clinical Data Collection

  NCT02860416

  Condition:   Neurological Observations
  Intervention:  
  Sponsor:   ElMindA Ltd
  Completed
• Lisinopril in Reducing Shortness of Breath Caused by Radiation Therapy in Patients With Lung Cancer

  NCT01880528

  Conditions:   Dyspnea;   Non-small Cell Lung Cancer;   Small Cell Lung Cancer
  Interventions:   Drug: lisinopril;   Drug: placebo
  Sponsors:   Mayo Clinic;   National Cancer Institute (NCI)
  Active, not recruiting
• Ruxolitinib Phosphate in Treating Patients With Relapsed or Refractory Diffuse Large B-Cell or Peripheral T-Cell Non-Hodgkin Lymphoma After Donor Stem Cell Transplant

  NCT01431209

  Conditions:   Recurrent Diffuse Large B-Cell Lymphoma;   Recurrent Mature T- and NK-Cell Non-Hodgkin Lymphoma;   Refractory Diffuse Large B-Cell Lymphoma;   Refractory Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma
  Interventions:   Other: Laboratory Biomarker Analysis;   Drug: Ruxolitinib Phosphate
  Sponsors:   University of Nebraska;   National Cancer Institute (NCI)
  Active, not recruiting
• Velocity 2: An Anthrax Vaccine and Antibiotics Clinical Study

  NCT04067011

  Condition:   Anthrax
  Interventions:   Drug: Ciprofloxacin 500Mg Tablet;   Drug: Doxycycline 100Mg Tablet;   Biological: AV7909
  Sponsors:   Emergent Product Development Gaithersburg, Inc.;   Biomedical Advanced Research and Development Authority
  Recruiting
• Validation of Patient Reported Outcome Measures for Use in Vulvodynia

  NCT03770169

  Condition:   Vulvodynia
  Intervention:  
  Sponsor:   Ipsen
  Recruiting
• Study of Ruxolitinib in Sclerotic Chronic Graft-Versus-Host Disease After Failure of Systemic Glucocorticoids

  NCT03616184

  Condition:   Graft-versus-host-disease (GVHD)
  Intervention:   Drug: Ruxolitinib
  Sponsor:   University of Nebraska
  Recruiting
• HEARTBiT: Multi-Marker Blood Test for Acute Cardiac Transplant Rejection

  NCT03575910

  Conditions:   Heart Transplant Failure and Rejection;   Heart Failure;   Heart Diseases;   Heart Failure，Congestive;   Transplant; Failure, Heart;   Transplant Failure
  Intervention:  
  Sponsors:   University of British Columbia;   Canadian Institutes of Health Research (CIHR);   PROOF Centre of Excellence;   Duke University;   University of Nebraska;   Toronto General Hospital;   St. Paul's Hospital, Canada
  Recruiting
• A Study of an Intratumoral Oncolytic Virus in Patients With Advanced Metastatic Solid Tumors

  NCT03954067

  Conditions:   Metastatic Cancer;   Solid Tumors;   Advanced Cancer
  Intervention:   Biological: ASP9801
  Sponsor:   Astellas Pharma Global Development, Inc.
  Recruiting
• Safety and Efficacy of Two Tetanus-Diphtheria Vaccines for a Donor Hyper Immunization Program

  NCT02673255

  Condition:   Healthy
  Intervention:   Biological: Tetanus and Diphtheria (Td) Vaccine
  Sponsors:   Biomat USA, Inc.;   Hammond Clinical Trial Consulting, LLC;   Axio Research. LLC
  Active, not recruiting
• Smith-Lemli-Opitz Syndrome and Cholic Acid

  NCT03720990

  Condition:   Smith-Lemli-Opitz Syndrome
  Intervention:   Drug: Cholic Acid
  Sponsors:   University of Nebraska;   University of Colorado, Denver;   Children's Hospital Medical Center, Cincinnati;   University of Pittsburgh
  Not yet recruiting
• A Trial of Concurrent Radiation Therapy, Cisplatin, and BMX-001 in Locally Advanced Head and Neck Cancer

  NCT02990468

  Condition:   Head and Neck Cancer
  Interventions:   Drug: BMX-001;   Radiation: Radiation Therapy;   Drug: Cisplatin
  Sponsors:   BioMimetix JV, LLC;   Duke University
  Recruiting
• A Study of Nivolumab +/- Nab-paclitaxel in Non-small Cell Lung Cancer

  NCT02967133

  Conditions:   Non-Small-Cell Lung Cancer Metastatic;   Non-Small Cell Carcinoma of Lung, TNM Stage 4;   Nonsmall Cell Lung Cancer;   Non Small Cell Lung Cancer Recurrent
  Interventions:   Drug: Nivolumab;   Drug: nab-paclitaxel
  Sponsors:   Alliance Foundation Trials, LLC.;   Celgene Corporation;   Bristol-Myers Squibb
  Active, not recruiting
• A PHASE 2B PLACEBO-CONTROLLED, RANDOMIZED STUDY OF A RESPIRATORY SYNCYTIAL VIRUS (RSV) VACCINE IN PREGNANT WOMEN

  NCT04032093

  Condition:   Respiratory Tract Infection
  Interventions:   Biological: RSV vaccine;   Biological: Placebo
  Sponsor:   Pfizer
  Recruiting
• Trial to Evaluate the Safety and Immunogenicity of 3 Lots of 20-valent Pneumococcal Conjugate Vaccine in Pneumococcal Vaccine-Naïve Adults

  NCT03828617

  Condition:   Pneumococcal Disease
  Interventions:   Biological: 20vPnC;   Biological: 13vPnC
  Sponsor:   Pfizer
  Active, not recruiting
• LIBERTY EXTENSION: Efficacy and Safety Extension Study of Relugolix in Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids

  NCT03412890

  Conditions:   Heavy Menstrual Bleeding;   Uterine Fibroid
  Interventions:   Drug: Relugolix;   Drug: Estradiol/norethindrone acetate
  Sponsor:   Myovant Sciences GmbH
  Active, not recruiting
• Inotuzumab Ozogamicin and Frontline Chemotherapy in Treating Young Adults With Newly Diagnosed B Acute Lymphoblastic Leukemia

  NCT03150693

  Condition:   B Acute Lymphoblastic Leukemia
  Interventions:   Drug: Allopurinol;   Drug: Cytarabine;   Drug: Daunorubicin Hydrochloride;   Drug: Vincristine Sulfate;   Drug: Dexamethasone;   Drug: Pegylated L-Asparaginase;   Drug: Methotrexate;   Procedure: Bone Marrow Aspiration and Biopsy;   Drug: Cyclophosphamide;   Drug: Mercaptopurine;   Biological: Rituximab;   Drug: Doxorubicin;   Drug: Thioguanine;   Biological: Inotuzumab Ozogamicin;   Other: Laboratory Biomarker Analysis
  Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI)
  Recruiting
• LIBERTY 1: Efficacy & Safety Study of Relugolix in Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids

  NCT03049735

  Conditions:   Heavy Menstrual Bleeding;   Uterine Fibroid
  Interventions:   Drug: Relugolix;   Drug: Estradiol/norethindrone acetate;   Drug: Placebo for E2/NETA;   Drug: Placebo for relugolix
  Sponsor:   Myovant Sciences GmbH
  Active, not recruiting
• A Study to Determine the Safety and Efficacy of the RSV F Vaccine to Protect Infants Via Maternal Immunization

  NCT02624947

  Condition:   Respiratory Syncytial Virus Infections
  Interventions:   Biological: RSV F vaccine with adjuvant;   Biological: Formulation buffer
  Sponsors:   Novavax;   Bill and Melinda Gates Foundation
  Completed
• Open-label Study to Evaluate Safety, Tolerability and PK of BHV-0223 in ALS

  NCT03520517

  Conditions:   Amyotrophic Lateral Sclerosis;   ALS;   Lou Gehrig Disease;   Lou Gehrig's Disease;   Lou-Gehrigs Disease;   Motor Neuron Disease, Amyotrophic Lateral Sclerosis
  Intervention:   Drug: BHV-0223
  Sponsors:   Biohaven Pharmaceuticals, Inc.;   Cognitive Research Corporation
  Completed
• A Multicenter, Double-blind, Randomized, Controlled, Roll-over Retreatment Study of the Safety and Pain Associated With Injections of PN40082, RV001 With Topical Anesthetic or RV001 for Lip Augmentation

  NCT04029545

  Condition:   Lip Augmentation
  Intervention:   Device: PN40082
  Sponsors:   Prollenium Medical Technologies Inc.;   Symbio, LLC
  Active, not recruiting
• A Study of AG-636 in the Treatment of Subjects With Advanced Lymphoma

  NCT03834584

  Condition:   Lymphoma
  Intervention:   Drug: AG-636
  Sponsor:   Agios Pharmaceuticals, Inc.
  Recruiting
• Ramucirumab and Pembrolizumab Versus Standard of Care in Treating Patients With Stage IV or Recurrent Non-small Cell Lung Cancer (A Lung-MAP Non-Match Treatment Trial)

  NCT03971474

  Conditions:   Recurrent Lung Non-Small Cell Carcinoma;   Stage IV Lung Cancer AJCC v8;   Stage IVA Lung Cancer AJCC v8;   Stage IVB Lung Cancer AJCC v8
  Interventions:   Drug: Docetaxel;   Drug: Gemcitabine;   Drug: Gemcitabine Hydrochloride;   Biological: Pembrolizumab;   Drug: Pemetrexed;   Drug: Pemetrexed Disodium;   Biological: Ramucirumab
  Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma

  NCT03937635

  Condition:   Smoldering Plasma Cell Myeloma
  Interventions:   Biological: Daratumumab;   Drug: Dexamethasone;   Drug: Lenalidomide;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration
  Sponsors:   ECOG-ACRIN Cancer Research Group;   National Cancer Institute (NCI)
  Recruiting
• Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

  NCT03851445

  Condition:   Previously Treated Non-Small Cell Lung Cancer
  Intervention:   Drug: Screening Platform
  Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

  NCT03866382

  Conditions:   Bladder Adenocarcinoma;   Bladder Mixed Adenocarcinoma;   Bladder Small Cell Carcinoma;   Bladder Squamous Cell Carcinoma;   Chromophobe Renal Cell Carcinoma;   Infiltrating Bladder Lymphoepithelioma-Like Carcinoma;   Infiltrating Bladder Urothelial Carcinoma;   Infiltrating Bladder Urothelial Carcinoma Sarcomatoid Variant;   Infiltrating Bladder Urothelial Carcinoma With Giant Cells;   Infiltrating Bladder Urothelial Carcinoma, Nested Variant;   Infiltrating Bladder Urothelial Carcinoma, Plasmacytoid Variant;   Kidney Medullary Carcinoma;   Large Cell Neuroendocrine Carcinoma;   Metastatic Bladder Carcinoma;   Metastatic Bladder Large Cell Neuroendocrine Carcinoma;   Metastatic Bladder Small Cell Carcinoma;   Metastatic Bladder Squamous Cell Carcinoma;   Metastatic Infiltrating Bladder Urothelial Carcinoma, Clear Cell Variant;   Metastatic Infiltrating Bladder Urothelial Carcinoma, Lipid-Rich Variant;   Metastatic Infiltrating Bladder Urothelial Carcinoma, Micropapillary Variant;   Metastatic Infiltrating Bladder Urothelial Carcinoma, Plasmacytoid Variant;   Metastatic Infiltrating Bladder Urothelial Carcinoma, Sarcomatoid Variant;   Metastatic Kidney Medullary Carcinoma;   Metastatic Malignant Genitourinary System Neoplasm;   Metastatic Penile Carcinoma;   Metastatic Prostate Small Cell Carcinoma;   Metastatic Sarcomatoid Renal Cell Carcinoma;   Papillary Renal Cell Carcinoma;   Sarcomatoid Renal Cell Carcinoma;   Stage IV Bladder Cancer AJCC v8;   Stage IV Penile Cancer AJCC v8;   Stage IV Prostate Cancer AJCC v8;   Stage IV Renal Cell Cancer AJCC v8;   Stage IVA Bladder Cancer AJCC v8;   Stage IVA Prostate Cancer AJCC v8;   Stage IVB Bladder Cancer AJCC v8;   Stage IVB Prostate Cancer AJCC v8;   Testicular Leydig Cell Tumor;   Testicular Sertoli Cell Tumor
  Interventions:   Drug: Cabozantinib;   Drug: Cabozantinib S-malate;   Biological: Ipilimumab;   Biological: Nivolumab
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Firstline Pembrolizumab Alone or in Combination With Pemetrexed and Carboplatin in Induction/Maintenance or Postprogression in Treating Patients With Stage IV Non-squamous Non-small Cell Lung Cancer

  NCT03793179

  Conditions:   Lung Non-Squamous Non-Small Cell Carcinoma;   Stage IIIB Lung Cancer AJCC v8;   Stage IIIC Lung Cancer AJCC v8;   Stage IVA Lung Cancer AJCC v8
  Interventions:   Drug: Carboplatin;   Biological: Pembrolizumab;   Drug: Pemetrexed
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Immunotherapy With Nivolumab and Ipilimumab Followed by Nivolumab or Nivolumab With Cabozantinib for Patients With Advanced Kidney Cancer, The PDIGREE Study

  NCT03793166

  Conditions:   Clear Cell Renal Cell Carcinoma;   Metastatic Malignant Neoplasm in Lymph Node;   Metastatic Malignant Neoplasm in the Bone;   Metastatic Malignant Neoplasm in the Soft Tissues;   Metastatic Malignant Neoplasm in the Viscera;   Sarcomatoid Renal Cell Carcinoma;   Stage IV Renal Cell Cancer AJCC v8
  Interventions:   Drug: Cabozantinib;   Biological: Ipilimumab;   Biological: Nivolumab;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Gemcitabine Hydrochloride and Cisplatin With or Without Nab-Paclitaxel in Treating Patients With Newly Diagnosed Advanced Biliary Tract Cancers

  NCT03768414

  Conditions:   Stage III Distal Bile Duct Cancer AJCC v8;   Stage III Gallbladder Cancer AJCC v8;   Stage III Intrahepatic Cholangiocarcinoma AJCC v8;   Stage IIIA Distal Bile Duct Cancer AJCC v8;   Stage IIIA Gallbladder Cancer AJCC v8;   Stage IIIA Intrahepatic Cholangiocarcinoma AJCC v8;   Stage IIIB Distal Bile Duct Cancer AJCC v8;   Stage IIIB Gallbladder Cancer AJCC v8;   Stage IIIB Intrahepatic Cholangiocarcinoma AJCC v8;   Stage IV Distal Bile Duct Cancer AJCC v8;   Stage IV Gallbladder Cancer AJCC v8;   Stage IV Intrahepatic Cholangiocarcinoma AJCC v8;   Stage IVA Gallbladder Cancer AJCC v8;   Stage IVB Gallbladder Cancer AJCC v8;   Unresectable Extrahepatic Bile Duct Carcinoma;   Unresectable Gallbladder Carcinoma;   Unresectable Intrahepatic Cholangiocarcinoma
  Interventions:   Drug: Cisplatin;   Drug: Gemcitabine Hydrochloride;   Drug: Nab-paclitaxel
  Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• Biomarker/ALK Inhibitor Combinations in Treating Patients With Stage IV ALK Positive Non-squamous Non-small Cell Lung Cancer (The NCI-NRG ALK Protocol)

  NCT03737994

  Conditions:   Lung Non-Squamous Non-Small Cell Carcinoma;   Stage IV Lung Cancer AJCC v8;   Stage IVA Lung Cancer AJCC v8;   Stage IVB Lung Cancer AJCC v8
  Interventions:   Drug: Alectinib;   Drug: Brigatinib;   Drug: Carboplatin;   Drug: Ceritinib;   Drug: Cisplatin;   Drug: Crizotinib;   Drug: Ensartinib;   Drug: Lorlatinib;   Drug: Pemetrexed
  Sponsors:   National Cancer Institute (NCI);   NRG Oncology
  Recruiting
• Testing Maintenance Immunotherapy Versus Observation in Patients With Oropharynx Cancer

  NCT03811015

  Conditions:   Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8;   Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8;   Pathologic Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8;   Pathologic Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
  Interventions:   Drug: Cisplatin;   Radiation: Intensity-Modulated Radiation Therapy;   Biological: Nivolumab;   Other: Patient Observation
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Serum Tumor Marker Directed Disease Monitoring in Patients With Hormone Receptor Positive Her2 Negative Metastatic Breast Cancer

  NCT03723928

  Conditions:   Anatomic Stage IV Breast Cancer AJCC v8;   Estrogen Receptor Positive;   HER2/Neu Negative;   Progesterone Receptor Positive;   Prognostic Stage IV Breast Cancer AJCC v8;   Elevated CA15-3 or CEA or CA27-29
  Interventions:   Other: Usual care disease monitoring;   Other: Serum Tumor Marker directed disease monitoring;   Other: Quality-of-Life Assessment;   Other: Anxiety Questionnaire Administration
  Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• Pembrolizumab in Treating Patients With Stage III-IV High-Risk Melanoma Before and After Surgery

  NCT03698019

  Conditions:   Acral Lentiginous Melanoma;   Clinical Stage III Cutaneous Melanoma AJCC v8;   Clinical Stage IV Cutaneous Melanoma AJCC v8;   Mucosal Melanoma;   Pathologic Stage III Cutaneous Melanoma AJCC v8;   Pathologic Stage IIIA Cutaneous Melanoma AJCC v8;   Pathologic Stage IIIB Cutaneous Melanoma AJCC v8;   Pathologic Stage IIIC Cutaneous Melanoma AJCC v8;   Pathologic Stage IIID Cutaneous Melanoma AJCC v8;   Pathologic Stage IV Cutaneous Melanoma AJCC v8
  Interventions:   Biological: Pembrolizumab;   Procedure: Therapeutic Conventional Surgery
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Ibrutinib and Obinutuzumab With or Without Venetoclax in Treating Patients With Chronic Lymphocytic Leukemia

  NCT03701282

  Conditions:   Chronic Lymphocytic Leukemia;   Small Lymphocytic Lymphoma
  Interventions:   Drug: Ibrutinib;   Biological: Obinutuzumab;   Other: Quality-of-Life Assessment;   Drug: Venetoclax
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Carboplatin and Paclitaxel With or Without Ramucirumab in Treating Patients With Locally Advanced, Recurrent, or Metastatic Thymic Cancer That Cannot Be Removed by Surgery

  NCT03694002

  Conditions:   Locally Advanced Thymic Carcinoma;   Metastatic Thymic Carcinoma;   Recurrent Thymic Carcinoma;   Unresectable Thymic Carcinoma
  Interventions:   Drug: Carboplatin;   Drug: Paclitaxel;   Biological: Ramucirumab
  Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• Olaparib and Cediranib Maleate in Treating Patients With Recurrent, Refractory, or Metastatic Endometrial Cancer

  NCT03660826

  Conditions:   Endometrial Undifferentiated Carcinoma;   Endometrioid Adenocarcinoma;   Recurrent Endometrial Serous Adenocarcinoma;   Recurrent Uterine Corpus Carcinoma;   Stage IV Uterine Corpus Cancer AJCC v7;   Stage IVA Uterine Corpus Cancer AJCC v7;   Stage IVB Uterine Corpus Cancer AJCC v7
  Interventions:   Drug: Cediranib;   Drug: Cediranib Maleate;   Drug: Olaparib
  Sponsors:   National Cancer Institute (NCI);   NRG Oncology
  Active, not recruiting
• Ruxolitinib Phosphate and Dasatinib or Nilotinib in Treating Patients With Chronic Myeloid Leukemia

  NCT03654768

  Condition:   Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive
  Interventions:   Drug: Dasatinib;   Other: Laboratory Biomarker Analysis;   Drug: Nilotinib;   Drug: Ruxolitinib Phosphate
  Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• Dexamethasone in Reducing Everolimus-Induced Oral Stomatitis in Patients With Cancer

  NCT03839940

  Condition:   Malignant Neoplasm
  Interventions:   Drug: Dexamethasone;   Other: Placebo;   Other: Questionnaire;   Other: Quality-of-Life Assessment;   Drug: Everolimus
  Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI)
  Recruiting
• Pembrolizumab and Epacadostat in Treating Patients With Recurrent, Persistent, or Progressive Ovarian Clear Cell Carcinoma

  NCT03602586

  Conditions:   Malignant Ovarian Clear Cell Tumor;   Recurrent Ovarian Carcinoma
  Interventions:   Drug: Epacadostat;   Biological: Pembrolizumab
  Sponsors:   National Cancer Institute (NCI);   NRG Oncology
  Suspended
• Dose Dense Gemcitabine and Cisplatin Without Cystectomy for Patients With Muscle Invasive Bladder Urothelial Cancer and Select Genetic Alterations

  NCT03609216

  Conditions:   Infiltrating Bladder Urothelial Carcinoma;   Stage II Bladder Urothelial Carcinoma;   Stage III Bladder Urothelial Carcinoma
  Interventions:   Drug: Gemcitabine Hydrochloride;   Drug: Cisplatin;   Biological: Pegfilgrastim;   Procedure: Conventional Surgery;   Procedure: Radical Cystectomy;   Other: Chemoradiotherapy
  Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI)
  Recruiting
• S1702 Isatuximab in Treating Patients With Relapsed or Refractory Primary Amyloidosis

  NCT03499808

  Conditions:   Amorphous, Eosinophilic, and Acellular Deposit;   Constipation;   Diarrhea;   Early Satiety;   Gastrointestinal Hemorrhage;   Hepatomegaly;   Lymphadenopathy;   Macroglossia;   Nausea;   Primary Systemic Amyloidosis;   Purpura;   Recurrent Primary Amyloidosis;   Refractory Primary Amyloidosis
  Interventions:   Biological: Isatuximab;   Other: Laboratory Biomarker Analysis
  Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• Nivolumab, Cabozantinib S-Malate, and Ipilimumab in Treating Patients With Recurrent Stage IV Non-small Cell Lung Cancer

  NCT03468985

  Conditions:   Metastatic Lung Non-Squamous Non-Small Cell Carcinoma;   Recurrent Lung Non-Squamous Non-Small Cell Carcinoma;   Stage IV Lung Non-Small Cell Cancer AJCC v7
  Interventions:   Drug: Cabozantinib;   Drug: Cabozantinib S-malate;   Biological: Ipilimumab;   Other: Laboratory Biomarker Analysis;   Biological: Nivolumab;   Other: Questionnaire Administration
  Sponsor:   National Cancer Institute (NCI)
  Active, not recruiting
• S1501 Carvedilol in Preventing Cardiac Toxicity in Patients With Metastatic HER-2-Positive Breast Cancer

  NCT03418961

  Conditions:   Cardiotoxicity;   HER2/Neu Positive;   Metastatic Malignant Neoplasm in the Brain;   Recurrent Breast Carcinoma;   Stage IV Breast Cancer AJCC v6 and v7
  Interventions:   Drug: Carvedilol;   Other: Laboratory Biomarker Analysis;   Other: Patient Observation
  Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• Hypofractionated Radiation Therapy After Mastectomy in Preventing Recurrence in Patients With Stage IIa-IIIa Breast Cancer

  NCT03414970

  Conditions:   Ductal Breast Carcinoma;   Invasive Breast Carcinoma;   Lobular Breast Carcinoma;   Medullary Breast Carcinoma;   Stage II Breast Cancer;   Stage IIA Breast Cancer;   Stage IIB Breast Cancer;   Stage IIIA Breast Cancer;   Tubular Breast Carcinoma
  Interventions:   Radiation: Radiation Therapy;   Other: Questionnaire Administration;   Other: Quality-of-Life Assessment;   Other: Laboratory Biomarker Analysis;   Radiation: Hypofractionated Radiation Therapy
  Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI);   Canadian Cancer Trials Group
  Recruiting
• Cisplatin/Carboplatin and Etoposide With or Without Nivolumab in Treating Patients With Extensive Stage Small Cell Lung Cancer

  NCT03382561

  Conditions:   Extensive Stage Lung Small Cell Carcinoma;   Recurrent Lung Small Cell Carcinoma
  Interventions:   Drug: Carboplatin;   Drug: Cisplatin;   Drug: Etoposide;   Biological: Nivolumab
  Sponsor:   National Cancer Institute (NCI)
  Active, not recruiting
• Olanzapine With or Without Fosaprepitant Dimeglumine in Preventing Chemotherapy Induced Nausea and Vomiting in Cancer Patients Receiving Highly Emetogenic Chemotherapy

  NCT03578081

  Condition:   Malignant Neoplasm
  Interventions:   Drug: Palonosetron Hydrochloride;   Drug: Ondansetron Hydrochloride;   Drug: Dexamethasone;   Drug: Fosaprepitant Dimeglumine;   Drug: Olanzapine;   Other: Placebo
  Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI)
  Recruiting
• S1613, Trastuzumab and Pertuzumab or Cetuximab and Irinotecan Hydrochloride in Treating Patients With Locally Advanced or Metastatic HER2/Neu Amplified Colorectal Cancer That Cannot Be Removed by Surgery

  NCT03365882

  Conditions:   Colon Adenocarcinoma;   ERBB2 Gene Amplification;   Rectal Adenocarcinoma;   Recurrent Colon Carcinoma;   Recurrent Rectal Carcinoma;   Stage III Colon Cancer AJCC v7;   Stage III Rectal Cancer AJCC v7;   Stage IIIA Colon Cancer AJCC v7;   Stage IIIA Rectal Cancer AJCC v7;   Stage IIIB Colon Cancer AJCC v7;   Stage IIIB Rectal Cancer AJCC v7;   Stage IIIC Colon Cancer AJCC v7;   Stage IIIC Rectal Cancer AJCC v7;   Stage IV Colon Cancer AJCC v7;   Stage IV Rectal Cancer AJCC v7;   Stage IVA Colon Cancer AJCC v7;   Stage IVA Rectal Cancer AJCC v7;   Stage IVB Colon Cancer AJCC v7;   Stage IVB Rectal Cancer AJCC v7
  Interventions:   Biological: Cetuximab;   Drug: Irinotecan Hydrochloride;   Other: Laboratory Biomarker Analysis;   Biological: Pertuzumab;   Biological: Trastuzumab;   Device: HER-2 testing
  Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
  Active, not recruiting
• Nivolumab After Combined Modality Therapy in Treating Patients With High Risk Stage II-IIIB Anal Cancer

  NCT03233711

  Conditions:   Anal Basaloid Carcinoma;   Anal Canal Cloacogenic Carcinoma;   Anal Margin Squamous Cell Carcinoma;   Stage IIB Anal Cancer AJCC v8;   Stage IIIA Anal Cancer AJCC v8;   Stage IIIB Anal Cancer AJCC v8;   Stage IIIC Anal Cancer AJCC v8
  Interventions:   Biological: Nivolumab;   Other: Patient Observation
  Sponsors:   National Cancer Institute (NCI);   Canadian Cancer Trials Group
  Recruiting
• Atezolizumab, Pemetrexed Disodium, Cisplatin, and Surgery With or Without Radiation Therapy in Treating Patients With Stage I-III Pleural Malignant Mesothelioma

  NCT03228537

  Conditions:   Biphasic Mesothelioma;   Epithelioid Mesothelioma;   Stage I Pleural Malignant Mesothelioma AJCC v7;   Stage IA Pleural Malignant Mesothelioma AJCC v7;   Stage IB Pleural Malignant Mesothelioma AJCC v7;   Stage II Pleural Malignant Mesothelioma AJCC v7;   Stage III Pleural Malignant Mesothelioma AJCC v7
  Interventions:   Drug: Atezolizumab;   Drug: Cisplatin;   Procedure: Extrapleural Pneumonectomy;   Drug: Pemetrexed Disodium;   Procedure: Pleurectomy;   Radiation: Radiation Therapy
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Naloxegol in Treating Patients With Stage IIIB-IV Non-small Cell Lung Cancer

  NCT03087708

  Conditions:   Stage IIIB Non-Small Cell Lung Cancer;   Stage IV Non-small Cell Lung Cancer
  Interventions:   Drug: Naloxegol;   Other: Placebo;   Other: Laboratory Biomarker Analysis;   Other: Quality-of-Life Assessment
  Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI)
  Recruiting
• Azacitidine With or Without Nivolumab or Midostaurin, or Decitabine and Cytarabine Alone in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome

  NCT03092674

  Conditions:   Acute Myeloid Leukemia;   Myelodysplastic Syndrome;   Myelodysplastic Syndrome With Excess Blasts-2
  Interventions:   Drug: Azacitidine;   Drug: Cytarabine;   Drug: Decitabine;   Other: Laboratory Biomarker Analysis;   Drug: Midostaurin;   Biological: Nivolumab
  Sponsor:   National Cancer Institute (NCI)
  Suspended
• Ipilimumab With or Without Nivolumab in Treating Patients With Melanoma That Is Stage IV or Stage III and Cannot Be Removed by Surgery

  NCT03033576

  Conditions:   Advanced Melanoma;   Melanoma of Unknown Primary;   Mucosal Melanoma;   Refractory Melanoma;   Stage III Cutaneous Melanoma AJCC v7;   Stage IIIA Cutaneous Melanoma AJCC v7;   Stage IIIB Cutaneous Melanoma AJCC v7;   Stage IIIC Cutaneous Melanoma AJCC v7;   Stage IV Cutaneous Melanoma AJCC v6 and v7;   Unresectable Cutaneous Melanoma;   Unresectable Melanoma
  Interventions:   Biological: Ipilimumab;   Biological: Nivolumab
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Medroxyprogesterone Acetate With or Without Entinostat Before Surgery in Treating Patients With Endometrioid Endometrial Cancer

  NCT03018249

  Conditions:   FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma;   FIGO Grade 2 Endometrial Endometrioid Adenocarcinoma;   FIGO Grade 3 Endometrial Endometrioid Adenocarcinoma;   Uterine Corpus Adenosarcoma
  Interventions:   Drug: Entinostat;   Procedure: Hysterectomy;   Other: Laboratory Biomarker Analysis;   Drug: Medroxyprogesterone Acetate
  Sponsors:   National Cancer Institute (NCI);   NRG Oncology
  Active, not recruiting
• A Study to Evaluate the Effect of Testosterone Replacement Therapy (TRT) on the Incidence of Major Adverse Cardiovascular Events (MACE) and Efficacy Measures in Hypogonadal Men ( TRAVERSE )

  NCT03518034

  Conditions:   Hypogonadism;   Cardiovascular Diseases
  Interventions:   Drug: Testosterone;   Drug: Placebo
  Sponsors:   AbbVie;   Acerus Pharmaceuticals Corporation;   Allergan Sales, LLC;   Endo Pharmaceuticals;   Upsher-Smith Laboratories
  Recruiting
• Aspirin in Preventing Recurrence of Cancer in Patients With HER2 Negative Stage II-III Breast Cancer After Chemotherapy, Surgery, and/or Radiation Therapy

  NCT02927249

  Condition:   Node Positive HER2 Negative Breast Cancer
  Interventions:   Other: Placebo;   Drug: Aspirin
  Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI);   United States Department of Defense;   Bayer;   Canadian Cancer Trials Group
  Recruiting
• Veliparib, Pembrolizumab, and Combination Chemotherapy in Treating Patient With Locally Advanced Rectal Cancer

  NCT02921256

  Conditions:   Rectal Adenocarcinoma;   Stage II Rectal Cancer AJCC v7;   Stage III Rectal Cancer AJCC v7
  Interventions:   Drug: Capecitabine;   Drug: Fluorouracil;   Radiation: Intensity-Modulated Radiation Therapy;   Drug: Leucovorin;   Drug: Leucovorin Calcium;   Drug: Oxaliplatin;   Biological: Pembrolizumab;   Drug: Veliparib
  Sponsors:   National Cancer Institute (NCI);   NRG Oncology
  Suspended
• Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair

  NCT02912559

  Conditions:   Colon Adenocarcinoma;   DNA Repair Disorder;   Lynch Syndrome;   Stage III Colon Cancer AJCC v7;   Stage IIIA Colon Cancer AJCC v7;   Stage IIIB Colon Cancer AJCC v7;   Stage IIIC Colon Cancer AJCC v7
  Interventions:   Drug: Atezolizumab;   Drug: Fluorouracil;   Other: Laboratory Biomarker Analysis;   Drug: Leucovorin Calcium;   Drug: Oxaliplatin;   Other: Quality-of-Life Assessment
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• FOLFIRI or Modified FOLFIRI and Veliparib as Second Line Therapy in Treating Patients With Metastatic Pancreatic Cancer

  NCT02890355

  Conditions:   Metastatic Pancreatic Adenocarcinoma;   Recurrent Pancreatic Carcinoma;   Stage IV Pancreatic Cancer AJCC v6 and v7
  Interventions:   Drug: Fluorouracil;   Drug: Irinotecan Hydrochloride;   Other: Laboratory Biomarker Analysis;   Drug: Leucovorin Calcium;   Drug: Veliparib
  Sponsor:   National Cancer Institute (NCI)
  Active, not recruiting
• Sapanisertib in Treating Patients With Metastatic or Refractory Pancreatic Neuroendocrine Tumor That Cannot Be Removed by Surgery

  NCT02893930

  Conditions:   Pancreatic Neuroendocrine Tumor G1;   Pancreatic Neuroendocrine Tumor G2;   Refractory Pancreatic Neuroendocrine Carcinoma
  Intervention:   Drug: Sapanisertib
  Sponsor:   National Cancer Institute (NCI)
  Suspended
• Pegylated Liposomal Doxorubicin Hydrochloride With Atezolizumab and/or Bevacizumab in Treating Patients With Recurrent Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

  NCT02839707

  Conditions:   Fallopian Tube Clear Cell Adenocarcinoma;   Fallopian Tube Endometrioid Adenocarcinoma;   Fallopian Tube Undifferentiated Carcinoma;   High Grade Fallopian Tube Serous Adenocarcinoma;   High Grade Ovarian Serous Adenocarcinoma;   Ovarian Clear Cell Adenocarcinoma;   Ovarian Endometrioid Adenocarcinoma;   Ovarian Seromucinous Carcinoma;   Ovarian Undifferentiated Carcinoma;   Platinum-Resistant Ovarian Carcinoma;   Primary Peritoneal High Grade Serous Adenocarcinoma;   Recurrent Fallopian Tube Carcinoma;   Recurrent Ovarian Carcinoma;   Recurrent Primary Peritoneal Carcinoma
  Interventions:   Drug: Atezolizumab;   Biological: Bevacizumab;   Drug: Pegylated Liposomal Doxorubicin Hydrochloride;   Other: Quality-of-Life Assessment
  Sponsors:   National Cancer Institute (NCI);   NRG Oncology
  Suspended
• Nivolumab and Ipilimumab in Treating Patients With Rare Tumors

  NCT02834013

  Conditions:   Acinar Cell Carcinoma;   Adenoid Cystic Carcinoma;   Adrenal Cortex Carcinoma;   Adrenal Gland Pheochromocytoma;   Anal Canal Neuroendocrine Carcinoma;   Anal Canal Undifferentiated Carcinoma;   Angiosarcoma;   Apocrine Neoplasm;   Appendix Mucinous Adenocarcinoma;   Bartholin Gland Transitional Cell Carcinoma;   Basal Cell Carcinoma;   Bladder Adenocarcinoma;   Cervical Adenocarcinoma;   Cervical Clear Cell Adenocarcinoma;   Cholangiocarcinoma;   Chordoma;   Colorectal Squamous Cell Carcinoma;   Desmoid-Type Fibromatosis;   Endometrial Transitional Cell Carcinoma;   Endometrioid Adenocarcinoma;   Esophageal Neuroendocrine Carcinoma;   Esophageal Undifferentiated Carcinoma;   Extrahepatic Bile Duct Carcinoma;   Extramammary Paget Disease;   Fallopian Tube Adenocarcinoma;   Fallopian Tube Transitional Cell Carcinoma;   Fibromyxoid Tumor;   Gallbladder Carcinoma;   Gastric Neuroendocrine Carcinoma;   Gastric Squamous Cell Carcinoma;   Gastric Undifferentiated Carcinoma;   Gastrointestinal Stromal Tumor;   Gestational Trophoblastic Tumor;   Giant Cell Carcinoma;   Intestinal Neuroendocrine Carcinoma;   Intrahepatic Cholangiocarcinoma;   Lung Carcinoid Tumor;   Lung Sarcomatoid Carcinoma;   Major Salivary Gland Carcinoma;   Malignant Odontogenic Neoplasm;   Malignant Peripheral Nerve Sheath Tumor;   Malignant Testicular Sex Cord-Stromal Tumor;   Metaplastic Breast Carcinoma;   Metastatic Malignant Neoplasm of Unknown Primary;   Minimally Invasive Lung Adenocarcinoma;   Mixed Mesodermal (Mullerian) Tumor;   Mucinous Adenocarcinoma;   Mucinous Cystadenocarcinoma;   Nasal Cavity Adenocarcinoma;   Nasal Cavity Carcinoma;   Nasopharyngeal Carcinoma;   Nasopharyngeal Papillary Adenocarcinoma;   Nasopharyngeal Undifferentiated Carcinoma;   Oral Cavity Carcinoma;   Oropharyngeal Undifferentiated Carcinoma;   Ovarian Adenocarcinoma;   Ovarian Clear Cell Adenocarcinoma;   Ovarian Germ Cell Tumor;   Ovarian Mucinous Adenocarcinoma;   Ovarian Squamous Cell Carcinoma;   Ovarian Transitional Cell Carcinoma;   Pancreatic Acinar Cell Carcinoma;   Pancreatic Neuroendocrine Carcinoma;   Paraganglioma;   Paranasal Sinus Adenocarcinoma;   Paranasal Sinus Carcinoma;   Parathyroid Gland Carcinoma;   PEComa;   Peritoneal Mesothelioma;   Pituitary Gland Carcinoma;   Placental Choriocarcinoma;   Primary Peritoneal High Grade Serous Adenocarcinoma;   Pseudomyxoma Peritonei;   Rare Disorder;   Scrotal Squamous Cell Carcinoma;   Seminal Vesicle Adenocarcinoma;   Seminoma;   Serous Cystadenocarcinoma;   Small Intestinal Adenocarcinoma;   Small Intestinal Squamous Cell Carcinoma;   Solid Neoplasm;   Spindle Cell Neoplasm;   Squamous Cell Carcinoma of the Penis;   Teratoma With Somatic-Type Malignancy;   Testicular Non-Seminomatous Germ Cell Tumor;   Thyroid Gland Carcinoma;   Tracheal Carcinoma;   Transitional Cell Carcinoma;   Ureter Adenocarcinoma;   Ureter Squamous Cell Carcinoma;   Urethral Adenocarcinoma;   Urethral Squamous Cell Carcinoma;   Vaginal Adenocarcinoma;   Vaginal Squamous Cell Carcinoma, Not Otherwise Specified;   Vulvar Carcinoma
  Interventions:   Procedure: Biospecimen Collection;   Biological: Ipilimumab;   Biological: Nivolumab
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Pembrolizumab With or Without Stereotactic Body Radiation Therapy in Treating Patients With Advanced or Metastatic Merkel Cell Cancer

  NCT03304639

  Conditions:   Stage III Merkel Cell Carcinoma AJCC v7;   Stage IIIA Merkel Cell Carcinoma AJCC v7;   Stage IIIB Merkel Cell Carcinoma AJCC v7;   Stage IV Merkel Cell Carcinoma AJCC v7
  Interventions:   Biological: Pembrolizumab;   Radiation: Stereotactic Body Radiation Therapy
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Lung-MAP: Nivolumab With or Without Ipilimumab as Second-Line Therapy in Treating Patients With Recurrent Stage IV Squamous Cell Lung Cancer and No Matching Biomarkers

  NCT02785952

  Conditions:   Recurrent Squamous Cell Lung Carcinoma;   Stage IV Squamous Cell Lung Carcinoma AJCC v7
  Interventions:   Biological: Ipilimumab;   Other: Laboratory Biomarker Analysis;   Biological: Nivolumab;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration
  Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
  Active, not recruiting
• Lung-MAP: Taselisib as Therapy in Treating Patients With Stage IV Squamous Cell Lung Cancer and Positive Biomarker Matches

  NCT02785913

  Conditions:   Recurrent Squamous Cell Lung Carcinoma;   Stage IV Squamous Cell Lung Carcinoma
  Interventions:   Other: Laboratory Biomarker Analysis;   Drug: Taselisib
  Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
  Active, not recruiting
• Pembrolizumab in Treating Patients With Triple-Negative Breast Cancer

  NCT02954874

  Conditions:   Invasive Breast Carcinoma;   Stage 0 Breast Cancer AJCC v6 and v7;   Stage I Breast Cancer AJCC v7;   Stage IA Breast Cancer AJCC v7;   Stage IB Breast Cancer AJCC v7;   Stage II Breast Cancer AJCC v6 and v7;   Stage IIA Breast Cancer AJCC v6 and v7;   Stage IIB Breast Cancer AJCC v6 and v7;   Stage III Breast Cancer AJCC v7;   Stage IIIA Breast Cancer AJCC v7;   Stage IIIB Breast Cancer AJCC v7;   Stage IIIC Breast Cancer AJCC v7;   Triple-Negative Breast Carcinoma
  Interventions:   Other: Laboratory Biomarker Analysis;   Other: Patient Observation;   Biological: Pembrolizumab;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration;   Radiation: Radiation Therapy
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Breast Cancer WEight Loss Study (BWEL Study)

  NCT02750826

  Condition:   Breast Carcinoma
  Interventions:   Other: Health Education Program;   Other: Weight Loss Intervention
  Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI);   Division of Cancer Control;   NIH Biomarker, Imaging and Quality of Life Studies Funding Program (BIQSFP);   Canadian Cancer Trials Group
  Recruiting
• Cabozantinib S-Malate, Crizotinib, Savolitinib, or Sunitinib Malate in Treating Patients With Locally Advanced or Metastatic Kidney Cancer

  NCT02761057

  Conditions:   Stage III Renal Cell Cancer AJCC v7;   Stage IV Renal Cell Cancer AJCC v7;   Type 1 Papillary Renal Cell Carcinoma;   Type 2 Papillary Renal Cell Carcinoma;   Unresectable Renal Cell Carcinoma
  Interventions:   Drug: Cabozantinib;   Drug: Cabozantinib S-malate;   Drug: Crizotinib;   Drug: Savolitinib;   Drug: Sunitinib;   Drug: Sunitinib Malate
  Sponsors:   National Cancer Institute (NCI);   Canadian Cancer Trials Group
  Recruiting
• S1417CD Financial Impact Assessment Tool in Patients With Metastatic Colorectal Cancer

  NCT02728804

  Conditions:   Stage IVA Colon Cancer;   Stage IVA Rectal Cancer;   Stage IVB Colon Cancer;   Stage IVB Rectal Cancer
  Interventions:   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration
  Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
  Active, not recruiting
• Sapanisertib or Pazopanib Hydrochloride in Treating Patients With Locally Advanced or Metastatic Sarcoma

  NCT02601209

  Conditions:   High Grade Sarcoma;   Metastatic Leiomyosarcoma;   Metastatic Malignant Peripheral Nerve Sheath Tumor;   Metastatic Synovial Sarcoma;   Metastatic Undifferentiated Pleomorphic Sarcoma;   Metastatic Unresectable Sarcoma;   Myxofibrosarcoma;   Recurrent Leiomyosarcoma;   Recurrent Malignant Peripheral Nerve Sheath Tumor;   Recurrent Synovial Sarcoma;   Recurrent Undifferentiated Pleomorphic Sarcoma;   Stage III Uterine Corpus Leiomyosarcoma AJCC v8;   Stage IIIA Uterine Corpus Leiomyosarcoma AJCC v8;   Stage IIIB Uterine Corpus Leiomyosarcoma AJCC v8;   Stage IIIC Uterine Corpus Leiomyosarcoma AJCC v8;   Stage IV Uterine Corpus Leiomyosarcoma AJCC v8;   Stage IVA Uterine Corpus Leiomyosarcoma AJCC v8;   Stage IVB Uterine Corpus Leiomyosarcoma AJCC v8;   Unresectable Leiomyosarcoma
  Interventions:   Drug: Pazopanib;   Drug: Pazopanib Hydrochloride;   Drug: Sapanisertib
  Sponsor:   National Cancer Institute (NCI)
  Active, not recruiting
• Cisplatin With or Without Veliparib in Treating Patients With Recurrent or Metastatic Triple-Negative and/or BRCA Mutation-Associated Breast Cancer With or Without Brain Metastases

  NCT02595905

  Conditions:   Breast Carcinoma Metastatic in the Brain;   Recurrent Breast Carcinoma;   Stage IV Breast Cancer AJCC v6 and v7;   Triple-Negative Breast Carcinoma
  Interventions:   Drug: Cisplatin;   Other: Laboratory Biomarker Analysis;   Other: Placebo;   Drug: Veliparib
  Sponsor:   National Cancer Institute (NCI)
  Active, not recruiting
• Vismodegib and FAK Inhibitor GSK2256098 in Treating Patients With Progressive Meningiomas

  NCT02523014

  Conditions:   Intracranial Meningioma;   Recurrent Meningioma;   NF2 Gene Mutation
  Interventions:   Drug: vismodegib;   Drug: GSK2256098
  Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI);   GlaxoSmithKline;   Genentech, Inc.;   Brain Science Foundation
  Suspended
• High-Dose Recombinant Interferon Alfa-2B, Ipilimumab, or Pembrolizumab in Treating Patients With Stage III-IV High Risk Melanoma That Has Been Removed by Surgery

  NCT02506153

  Conditions:   Metastatic Cutaneous Melanoma;   Metastatic Non-Cutaneous Melanoma;   Non-Cutaneous Melanoma;   Recurrent Cutaneous Melanoma;   Recurrent Non-Cutaneous Melanoma;   Stage III Cutaneous Melanoma AJCC v7;   Stage III Mucosal Melanoma of the Head and Neck AJCC v7;   Stage IIIA Cutaneous Melanoma AJCC v7;   Stage IIIB Cutaneous Melanoma AJCC v7;   Stage IIIC Cutaneous Melanoma AJCC v7;   Stage IV Cutaneous Melanoma AJCC v6 and v7;   Stage IVA Mucosal Melanoma of the Head and Neck AJCC v7;   Stage IVB Mucosal Melanoma of the Head and Neck AJCC v7;   Stage IVC Mucosal Melanoma of the Head and Neck AJCC v7
  Interventions:   Biological: Ipilimumab;   Biological: Pembrolizumab;   Other: Quality-of-Life Assessment;   Biological: Recombinant Interferon Alfa-2b
  Sponsor:   National Cancer Institute (NCI)
  Active, not recruiting
• Nivolumab With or Without Ipilimumab in Treating Patients With Metastatic Sarcoma That Cannot Be Removed by Surgery

  NCT02500797

  Conditions:   Dedifferentiated Liposarcoma;   Gastrointestinal Stromal Tumor;   Locally Advanced Bone Sarcoma;   Locally Advanced Soft Tissue Sarcoma;   Metastatic Bone Sarcoma;   Metastatic Liposarcoma;   Metastatic Soft Tissue Sarcoma;   Metastatic Undifferentiated Pleomorphic Sarcoma;   Metastatic Unresectable Sarcoma;   Pleomorphic Liposarcoma;   Stage III Bone Sarcoma AJCC v7;   Stage III Soft Tissue Sarcoma AJCC v7;   Stage IV Bone Sarcoma AJCC v7;   Stage IV Soft Tissue Sarcoma AJCC v7;   Stage IVA Bone Sarcoma AJCC v7;   Stage IVB Bone Sarcoma AJCC v7;   Unresectable Bone Sarcoma;   Unresectable Liposarcoma;   Unresectable Soft Tissue Sarcoma
  Interventions:   Biological: Ipilimumab;   Other: Laboratory Biomarker Analysis;   Biological: Nivolumab;   Other: Quality-of-Life Assessment
  Sponsor:   National Cancer Institute (NCI)
  Active, not recruiting
• Nivolumab With or Without Ipilimumab in Treating Patients With Persistent or Recurrent Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

  NCT02498600

  Conditions:   Recurrent Fallopian Tube Carcinoma;   Recurrent Ovarian Carcinoma;   Recurrent Primary Peritoneal Carcinoma
  Interventions:   Biological: Ipilimumab;   Biological: Nivolumab
  Sponsors:   National Cancer Institute (NCI);   NRG Oncology
  Active, not recruiting
• Doxorubicin Hydrochloride and Cyclophosphamide Followed by Paclitaxel With or Without Carboplatin in Treating Patients With Triple-Negative Breast Cancer

  NCT02488967

  Conditions:   Breast Adenocarcinoma;   Estrogen Receptor Negative;   HER2/Neu Negative;   Progesterone Receptor Negative;   Stage IB Breast Cancer;   Stage IIA Breast Cancer;   Stage IIB Breast Cancer;   Stage IIIA Breast Cancer;   Stage IIIC Breast Cancer;   Triple-Negative Breast Carcinoma
  Interventions:   Drug: Carboplatin;   Drug: Cyclophosphamide;   Drug: Doxorubicin Hydrochloride;   Other: Laboratory Biomarker Analysis;   Drug: Paclitaxel
  Sponsors:   NRG Oncology;   National Cancer Institute (NCI)
  Recruiting
• Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

  NCT02465060

  Conditions:   Advanced Malignant Solid Neoplasm;   Bladder Carcinoma;   Breast Carcinoma;   Cervical Carcinoma;   Colon Carcinoma;   Colorectal Carcinoma;   Endometrial Carcinoma;   Esophageal Carcinoma;   Gastric Carcinoma;   Glioma;   Head and Neck Carcinoma;   Kidney Carcinoma;   Liver and Intrahepatic Bile Duct Carcinoma;   Lung Carcinoma;   Lymphoma;   Malignant Uterine Neoplasm;   Melanoma;   Ovarian Carcinoma;   Pancreatic Carcinoma;   Plasma Cell Myeloma;   Prostate Carcinoma;   Rectal Carcinoma;   Recurrent Bladder Carcinoma;   Recurrent Breast Carcinoma;   Recurrent Cervical Carcinoma;   Recurrent Colon Carcinoma;   Recurrent Colorectal Carcinoma;   Recurrent Esophageal Carcinoma;   Recurrent Gastric Carcinoma;   Recurrent Glioma;   Recurrent Head and Neck Carcinoma;   Recurrent Liver Carcinoma;   Recurrent Lung Carcinoma;   Recurrent Lymphoma;   Recurrent Malignant Solid Neoplasm;   Recurrent Melanoma;   Recurrent Ovarian Carcinoma;   Recurrent Pancreatic Carcinoma;   Recurrent Plasma Cell Myeloma;   Recurrent Prostate Carcinoma;   Recurrent Rectal Carcinoma;   Recurrent Skin Carcinoma;   Recurrent Thyroid Gland Carcinoma;   Recurrent Uterine Corpus Carcinoma;   Refractory Lymphoma;   Refractory Malignant Solid Neoplasm;   Refractory Plasma Cell Myeloma;   Skin Carcinoma;   Thyroid Gland Carcinoma;   Uterine Corpus Cancer
  Interventions:   Drug: Adavosertib;   Drug: Afatinib;   Drug: Afatinib Dimaleate;   Drug: Binimetinib;   Drug: Capivasertib;   Drug: Copanlisib;   Drug: Copanlisib Hydrochloride;   Drug: Crizotinib;   Other: Cytology Specimen Collection Procedure;   Drug: Dabrafenib;   Drug: Dabrafenib Mesylate;   Drug: Dasatinib;   Drug: Defactinib;   Drug: Defactinib Hydrochloride;   Drug: Erdafitinib;   Drug: FGFR Inhibitor AZD4547;   Drug: Ipatasertib;   Other: Laboratory Biomarker Analysis;   Drug: Larotrectinib;   Drug: Larotrectinib Sulfate;   Biological: Nivolumab;   Drug: Osimertinib;   Drug: Palbociclib;   Biological: Pertuzumab;   Drug: PI3K-beta Inhibitor GSK2636771;   Drug: Sapanisertib;   Drug: Sunitinib Malate;   Drug: Taselisib;   Drug: Trametinib;   Biological: Trastuzumab;   Biological: Trastuzumab Emtansine;   Drug: Ulixertinib;   Drug: Vismodegib
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Nivolumab After Surgery and Chemotherapy in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer (An ALCHEMIST Treatment Trial)

  NCT02595944

  Conditions:   Stage IB Lung Non-Small Cell Carcinoma AJCC v7;   Stage II Lung Non-Small Cell Cancer AJCC v7;   Stage IIA Lung Non-Small Cell Carcinoma AJCC v7;   Stage IIB Lung Non-Small Cell Carcinoma AJCC v7;   Stage IIIA Lung Non-Small Cell Cancer AJCC v7
  Intervention:   Biological: Nivolumab
  Sponsor:   National Cancer Institute (NCI)
  Active, not recruiting
• Radiation Therapy and Cisplatin With or Without Triapine in Treating Patients With Newly Diagnosed Stage IB2, II, or IIIB-IVA Cervical Cancer or Stage II-IVA Vaginal Cancer

  NCT02466971

  Conditions:   Cervical Adenocarcinoma;   Cervical Adenosquamous Carcinoma;   Cervical Squamous Cell Carcinoma, Not Otherwise Specified;   Stage IB2 Cervical Cancer AJCC v6 and v7;   Stage II Cervical Cancer AJCC v7;   Stage II Vaginal Cancer AJCC v6 and v7;   Stage IIA Cervical Cancer AJCC v7;   Stage IIB Cervical Cancer AJCC v6 and v7;   Stage III Vaginal Cancer AJCC v6 and v7;   Stage IIIB Cervical Cancer AJCC v6 and v7;   Stage IVA Cervical Cancer AJCC v6 and v7;   Stage IVA Vaginal Cancer AJCC v6 and v7;   Vaginal Adenocarcinoma;   Vaginal Adenosquamous Carcinoma;   Vaginal Squamous Cell Carcinoma, Not Otherwise Specified
  Interventions:   Drug: Cisplatin;   Radiation: External Beam Radiation Therapy;   Radiation: Intensity-Modulated Radiation Therapy;   Radiation: Internal Radiation Therapy;   Other: Laboratory Biomarker Analysis;   Radiation: Radiation Therapy;   Drug: Triapine
  Sponsors:   National Cancer Institute (NCI);   NRG Oncology
  Recruiting
• Tamoxifen Citrate or Z-Endoxifen Hydrochloride in Treating Patients With Locally Advanced or Metastatic, Estrogen Receptor-Positive, HER2-Negative Breast Cancer

  NCT02311933

  Conditions:   Recurrent Breast Carcinoma;   Stage III Breast Cancer AJCC v7;   Stage IIIA Breast Cancer AJCC v7;   Stage IIIB Breast Cancer AJCC v7;   Stage IIIC Breast Cancer AJCC v7;   Stage IV Breast Cancer AJCC v6 and v7
  Interventions:   Other: Laboratory Biomarker Analysis;   Other: Pharmacological Study;   Drug: Tamoxifen Citrate;   Drug: Z-Endoxifen Hydrochloride
  Sponsor:   National Cancer Institute (NCI)
  Active, not recruiting
• Nivolumab in Treating Patients With Persistent, Recurrent, or Metastatic Cervical Cancer

  NCT02257528

  Conditions:   Cervical Adenocarcinoma;   Cervical Adenosquamous Carcinoma;   Recurrent Cervical Carcinoma;   Stage IV Cervical Cancer AJCC v6 and v7;   Stage IVA Cervical Cancer AJCC v6 and v7;   Stage IVB Cervical Cancer AJCC v6 and v7
  Interventions:   Other: Laboratory Biomarker Analysis;   Biological: Nivolumab
  Sponsors:   National Cancer Institute (NCI);   NRG Oncology
  Active, not recruiting
• Dabrafenib and Trametinib Followed by Ipilimumab and Nivolumab or Ipilimumab and Nivolumab Followed by Dabrafenib and Trametinib in Treating Patients With Stage III-IV BRAFV600 Melanoma

  NCT02224781

  Conditions:   Metastatic Melanoma;   Recurrent Melanoma;   Stage III Cutaneous Melanoma AJCC v7;   Stage IIIA Cutaneous Melanoma AJCC v7;   Stage IIIB Cutaneous Melanoma AJCC v7;   Stage IIIC Cutaneous Melanoma AJCC v7;   Stage IV Cutaneous Melanoma AJCC v6 and v7;   Unresectable Cutaneous Melanoma
  Interventions:   Drug: Dabrafenib;   Drug: Dabrafenib Mesylate;   Biological: Ipilimumab;   Biological: Nivolumab;   Other: Quality-of-Life Assessment;   Drug: Trametinib;   Drug: Trametinib Dimethyl Sulfoxide
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Crizotinib in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been Removed by Surgery and ALK Fusion Mutations (An ALCHEMIST Treatment Trial)

  NCT02201992

  Conditions:   ALK Gene Rearrangement;   ALK Gene Translocation;   ALK Positive;   Stage IB Non-Small Cell Lung Carcinoma AJCC v7;   Stage II Non-Small Cell Lung Cancer AJCC v7;   Stage IIA Non-Small Cell Lung Carcinoma AJCC v7;   Stage IIB Non-Small Cell Lung Carcinoma AJCC v7;   Stage IIIA Non-Small Cell Lung Cancer AJCC v7
  Interventions:   Other: Clinical Observation;   Drug: Crizotinib;   Other: Laboratory Biomarker Analysis
  Sponsors:   ECOG-ACRIN Cancer Research Group;   National Cancer Institute (NCI)
  Recruiting
• Genetic Testing in Screening Patients With Stage IB-IIIA Non-Small Cell Lung Cancer That Has Been or Will Be Removed by Surgery (The ALCHEMIST Screening Trial)

  NCT02194738

  Conditions:   Lung Adenocarcinoma;   Lung Large Cell Carcinoma;   Stage IB Lung Non-Small Cell Carcinoma AJCC v7;   Stage IB Lung Squamous Cell Carcinoma AJCC v7;   Stage II Lung Non-Small Cell Cancer AJCC v7;   Stage II Lung Squamous Cell Carcinoma AJCC v7;   Stage IIA Lung Non-Small Cell Carcinoma AJCC v7;   Stage IIA Lung Squamous Cell Carcinoma AJCC v7;   Stage IIB Lung Non-Small Cell Carcinoma AJCC v7;   Stage IIB Lung Squamous Cell Carcinoma AJCC v7;   Stage IIIA Lung Non-Small Cell Cancer AJCC v7;   Stage IIIA Lung Squamous Cell Carcinoma AJCC v7
  Interventions:   Other: Clinical Observation;   Drug: Crizotinib;   Other: Cytology Specimen Collection Procedure;   Drug: Erlotinib Hydrochloride;   Biological: Nivolumab;   Other: Placebo
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Erlotinib Hydrochloride in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been Completely Removed by Surgery (An ALCHEMIST Treatment Trial)

  NCT02193282

  Conditions:   EGFR Exon 19 Deletion Mutation;   EGFR NP_005219.2:p.L858R;   Stage IB Lung Non-Small Cell Carcinoma AJCC v7;   Stage II Lung Non-Small Cell Cancer AJCC v7;   Stage IIA Lung Non-Small Cell Carcinoma AJCC v7;   Stage IIB Lung Non-Small Cell Carcinoma AJCC v7;   Stage IIIA Lung Non-Small Cell Cancer AJCC v7
  Interventions:   Other: Clinical Observation;   Drug: Erlotinib Hydrochloride;   Other: Laboratory Biomarker Analysis;   Other: Placebo
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Dabrafenib and Trametinib in Treating Patients With Stage III-IV BRAF Mutant Melanoma That Cannot Be Removed by Surgery

  NCT02196181

  Conditions:   BRAF V600E Mutation Present;   BRAF V600K Mutation Present;   Stage III Cutaneous Melanoma AJCC v7;   Stage IIIA Cutaneous Melanoma AJCC v7;   Stage IIIB Cutaneous Melanoma AJCC v7;   Stage IIIC Cutaneous Melanoma AJCC v7;   Stage IV Cutaneous Melanoma AJCC v6 and v7;   Unresectable Melanoma
  Interventions:   Drug: Dabrafenib;   Drug: Dabrafenib Mesylate;   Drug: Trametinib;   Drug: Trametinib Dimethyl Sulfoxide
  Sponsor:   National Cancer Institute (NCI)
  Active, not recruiting
• S1406 Phase II Study of Irinotecan and Cetuximab With or Without Vemurafenib in BRAF Mutant Metastatic Colorectal Cancer

  NCT02164916

  Condition:   Colorectal Cancer
  Interventions:   Biological: cetuximab;   Drug: irinotecan hydrochloride;   Drug: vemurafenib
  Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI);   Roche-Genentech
  Active, not recruiting
• Lung-MAP: Biomarker-Targeted Second-Line Therapy in Treating Patients With Recurrent Stage IV Squamous Cell Lung Cancer

  NCT02154490

  Conditions:   Recurrent Squamous Cell Lung Carcinoma;   Stage IV Squamous Cell Lung Carcinoma AJCC v7
  Interventions:   Drug: Docetaxel;   Biological: Durvalumab;   Drug: Erlotinib Hydrochloride;   Drug: FGFR Inhibitor AZD4547;   Biological: Ipilimumab;   Other: Laboratory Biomarker Analysis;   Biological: Nivolumab;   Drug: Palbociclib;   Other: Pharmacological Study;   Biological: Rilotumumab;   Drug: Talazoparib;   Drug: Taselisib;   Biological: Tremelimumab
  Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
  Active, not recruiting
• S1300: Pemetrexed Disodium With or Without Crizotinib in Treating Patients With Stage IV Non-Small Cell Lung Cancer That Has Progressed After Crizotinib

  NCT02134912

  Conditions:   Adenocarcinoma of the Lung;   Large Cell Lung Cancer;   Recurrent Non-small Cell Lung Cancer;   Stage IV Non-small Cell Lung Cancer
  Interventions:   Drug: crizotinib;   Drug: pemetrexed disodium;   Other: laboratory biomarker analysis;   Other: pharmacological study
  Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
  Terminated
• Temozolomide With or Without Veliparib in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

  NCT02152982

  Conditions:   Glioblastoma;   Gliosarcoma
  Interventions:   Other: Laboratory Biomarker Analysis;   Other: Placebo;   Other: Quality-of-Life Assessment;   Drug: Temozolomide;   Drug: Veliparib
  Sponsor:   National Cancer Institute (NCI)
  Active, not recruiting
• Trametinib in Treating Patients With Recurrent or Progressive Low-Grade Ovarian Cancer or Peritoneal Cavity Cancer

  NCT02101788

  Conditions:   Micropapillary Serous Carcinoma;   Ovarian Serous Adenocarcinoma;   Primary Peritoneal Serous Adenocarcinoma;   Recurrent Low Grade Ovarian Serous Adenocarcinoma;   Recurrent Primary Peritoneal Serous Adenocarcinoma
  Interventions:   Drug: Letrozole;   Drug: Paclitaxel;   Drug: Pegylated Liposomal Doxorubicin Hydrochloride;   Other: Quality-of-Life Assessment;   Drug: Tamoxifen;   Drug: Tamoxifen Citrate;   Drug: Topotecan;   Drug: Topotecan Hydrochloride;   Drug: Trametinib;   Drug: Trametinib Dimethyl Sulfoxide
  Sponsors:   National Cancer Institute (NCI);   NRG Oncology
  Active, not recruiting
• Sorafenib Tosylate in Treating Patients With Desmoid Tumors or Aggressive Fibromatosis

  NCT02066181

  Condition:   Desmoid-Type Fibromatosis
  Interventions:   Other: Laboratory Biomarker Analysis;   Other: Placebo;   Other: Quality-of-Life Assessment;   Drug: Sorafenib Tosylate
  Sponsor:   National Cancer Institute (NCI)
  Active, not recruiting
• Ibrutinib and Rituximab Compared With Fludarabine Phosphate, Cyclophosphamide, and Rituximab in Treating Patients With Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

  NCT02048813

  Conditions:   Anemia;   Chronic Lymphocytic Leukemia;   Small Lymphocytic Lymphoma
  Interventions:   Drug: Cyclophosphamide;   Drug: Fludarabine Phosphate;   Drug: Ibrutinib;   Other: Laboratory Biomarker Analysis;   Other: Pharmacogenomic Study;   Other: Quality-of-Life Assessment;   Biological: Rituximab
  Sponsor:   National Cancer Institute (NCI)
  Active, not recruiting
• Docetaxel, Carboplatin, Trastuzumab, and Pertuzumab With or Without Estrogen Deprivation in Treating Patients With Hormone Receptor-Positive, HER2-Positive Operable or Locally Advanced Breast Cancer

  NCT02003209

  Conditions:   HER2/Neu Positive;   Stage IB Breast Cancer AJCC v7;   Stage IIA Breast Cancer AJCC v6 and v7;   Stage IIB Breast Cancer AJCC v6 and v7;   Stage IIIA Breast Cancer AJCC v7;   Stage IIIB Breast Cancer AJCC v7;   Stage IIIC Breast Cancer AJCC v7
  Interventions:   Drug: Aromatase Inhibition Therapy;   Drug: Carboplatin;   Other: Cytology Specimen Collection Procedure;   Drug: Docetaxel;   Drug: Goserelin Acetate;   Other: Laboratory Biomarker Analysis;   Biological: Pertuzumab;   Other: Quality-of-Life Assessment;   Procedure: Therapeutic Conventional Surgery;   Biological: Trastuzumab;   Radiation: Whole Breast Irradiation
  Sponsors:   National Cancer Institute (NCI);   NRG Oncology
  Active, not recruiting
• Fulvestrant and/or Anastrozole in Treating Postmenopausal Patients With Stage II-III Breast Cancer Undergoing Surgery

  NCT01953588

  Conditions:   Estrogen Receptor-positive Breast Cancer;   HER2-negative Breast Cancer;   Invasive Ductal Breast Carcinoma;   Invasive Lobular Breast Carcinoma;   Recurrent Breast Cancer;   Stage II Breast Cancer;   Stage IIIA Breast Cancer;   Stage IIIB Breast Cancer;   Stage IIIC Breast Cancer
  Interventions:   Drug: fulvestrant;   Drug: anastrozole
  Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI)
  Active, not recruiting
• Integrated Cancer Repository for Cancer Research

  NCT02012699

  Conditions:   Pancreatic Cancer;   Thyroid Cancer;   Lung Cancer;   Esophageal Cancer;   Thymus Cancer;   Colon Cancer;   Rectal Cancer;   GIST;   Anal Cancer;   Bile Duct Cancer;   Duodenal Cancer;   Gallbladder Cancer;   Gastric Cancer;   Liver Cancer;   Small Intestine Cancer;   Peritoneal Surface Malignancies;   Familial Adenomatous Polyposis;   Lynch Syndrome;   Bladder Cancer;   Kidney Cancer;   Penile Cancer;   Prostate Cancer;   Testicular Cancer;   Ureter Cancer;   Urethral Cancer;   Hypopharyngeal Cancer;   Laryngeal Cancer;   Lip Cancer;   Oral Cavity Cancer;   Nasopharyngeal Cancer;   Oropharyngeal Cancer;   Paranasal Sinus Cancer;   Nasal Cavity Cancer;   Salivary Gland Cancer;   Skin Cancer;   CNS Tumor;   CNS Cancer;   Mesothelioma;   Breast Cancer;   Leukemia;   Melanoma;   Sarcoma;   Unknown Primary Tumor;   Multiple Myeloma;   Ovarian Cancer;   Endometrial Cancer;   Vaginal Cancer;   Neuroendocrine Tumors;   Plasma Cell Dyscrasia;   Healthy Control
  Intervention:  
  Sponsor:   University of Nebraska
  Recruiting
• Ipilimumab With or Without Bevacizumab in Treating Patients With Stage III-IV Melanoma That Cannot Be Removed by Surgery

  NCT01950390

  Conditions:   Stage IIIC Cutaneous Melanoma AJCC v7;   Stage IV Cutaneous Melanoma AJCC v6 and v7;   Unresectable Melanoma
  Interventions:   Biological: Bevacizumab;   Biological: Ipilimumab
  Sponsor:   National Cancer Institute (NCI)
  Active, not recruiting
• Olaparib as Adjuvant Treatment in Patients With Germline BRCA Mutated High Risk HER2 Negative Primary Breast Cancer

  NCT02032823

  Condition:   Breast Cancer
  Interventions:   Drug: Olaparib;   Drug: Placebo
  Sponsors:   AstraZeneca;   Breast International Group;   Frontier Science & Technology Research Foundation, Inc.;   NRG Oncology;   Myriad Genetic Laboratories, Inc.;   Br.E.A.S.T. -Data Center & Operational Office Institut Jules Bordet;   Merck Sharp & Dohme Corp.
  Active, not recruiting
• Brentuximab Vedotin and Nivolumab With or Without Ipilimumab in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma

  NCT01896999

  Conditions:   Recurrent Classic Hodgkin Lymphoma;   Refractory Classic Hodgkin Lymphoma
  Interventions:   Drug: Brentuximab Vedotin;   Biological: Ipilimumab;   Biological: Nivolumab
  Sponsor:   National Cancer Institute (NCI)
  Recruiting