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• Precision Nutrition and Metabolic Function

  NCT04131166

  Conditions:   Obesity;   Insulin Resistance
  Interventions:   Behavioral: Mediterranean diet;   Behavioral: Low-carbohydrate, ketogenic diet;   Behavioral: Low-fat diet;   Other: Annual follow-up testing for 5 years
  Sponsors:   Washington University School of Medicine;   Centene Corporation
  Recruiting
• Implementation Intentions for Weight Loss and Dietary Change in College Students With Overweight and Obesity

  NCT04105309

  Condition:   Obesity
  Interventions:   Behavioral: Implementation Intentions;   Behavioral: Fluency Training;   Behavioral: Text Messages;   Behavioral: Goal Intentions
  Sponsor:   Washington University School of Medicine
  Completed
• MOCHI: An RCT of Mindfulness as Treatment for Chronic Pelvic Pain in AD Women

  NCT04104542

  Conditions:   Chronic Pelvic Pain;   Depression
  Interventions:   Behavioral: Mindfulness based stress reduction;   Behavioral: Healthy Lifestyle
  Sponsor:   University of Missouri, Kansas City
  Recruiting
• Fiber Blends and Gut Microbiota (FB)

  NCT04101344

  Condition:   Gut Microbiome
  Intervention:   Other: Two fiber-blend snack and four fiber-blend snack
  Sponsor:   Washington University School of Medicine
  Recruiting
• Impact of Exercise on Diastasis Rectus Abdominus

  NCT04049487

  Condition:   Diastasis Recti and Weakness of the Linea Alba
  Intervention:   Other: Exercise
  Sponsor:   University of Missouri-Columbia
  Not yet recruiting
• Comparison of Movement Pattern Training and Manual Therapy for Prearthritic Hip Disorders

  NCT03959319

  Conditions:   Hip-related Groin Pain;   Femoroacetabular Impingement;   Dysplasia Mild;   Prearthritic Hip Disorder
  Interventions:   Other: Movement Pattern Training;   Other: Manual Therapy
  Sponsors:   Washington University School of Medicine;   Foundation for Physical Therapy, Inc.
  Recruiting
• Weight Stigma Effect on Neural Control of Appetite

  NCT03934424

  Condition:   Appetitive Behavior
  Interventions:   Behavioral: Weight stigma;   Behavioral: Ethnic stigma
  Sponsor:   University of Missouri-Columbia
  Recruiting
• Pharmacokinetics of Oxytocin at Cesarean Delivery

  NCT03898882

  Condition:   Postpartum Hemorrhage
  Interventions:   Drug: oxytocin;   Device: Shore durometer
  Sponsor:   Washington University School of Medicine
  Recruiting
• Bioequivalence Study of Once Daily PMR Compared to Twice Daily Cilostazol IR Tablets in Healthy Volunteers

  NCT03864666

  Condition:   Intermittent Claudication
  Interventions:   Drug: Cilostazol 100 mg;   Drug: PMR 200 mg
  Sponsor:   Genovate Biotechnology Co., Ltd.,
  Completed
• Safety, Tolerability, and Immunogenicity of CRV-101 in Healthy Adult Subjects

  NCT03820414

  Conditions:   Herpes Zoster;   Varicella Zoster
  Interventions:   Biological: CRV 101;   Biological: Placebo
  Sponsors:   Curevo Inc;   IDRI;   Mogam Biotechnology Research Institute;   Green Cross Corporation
  Active, not recruiting
• Pgp Transporter and CNS Biodistribution of Ondansetron in Healthy Volunteers

  NCT03809234

  Condition:   Neuropathic Pain
  Interventions:   Drug: Ondansetron 8mg with Saline & Tariquidar;   Drug: Ondansetron 16mg with Saline & Tariquidar
  Sponsor:   Washington University School of Medicine
  Recruiting
• Safety, Tolerability and Immunogenicity of INO-4500 in Healthy Volunteers

  NCT03805984

  Condition:   Lassa Fever
  Interventions:   Drug: INO-4500;   Drug: Placebo;   Device: CELLECTRA® 2000
  Sponsors:   Inovio Pharmaceuticals;   Coalition for Epidemic Preparedness Innovations (CEPI)
  Recruiting
• Phase 1 Clinical Trial of Single-Vial ID93 + GLA-SE in Healthy Adults

  NCT03722472

  Condition:   Pulmonary TB
  Intervention:   Biological: ID93 + GLA-SE
  Sponsors:   IDRI;   National Institutes of Health (NIH);   National Institute of Allergy and Infectious Diseases (NIAID)
  Active, not recruiting
• A Biologic Joint Replacement Strategy for Knee Trauma and Post-Traumatic Osteoarthritis

  NCT03719417

  Conditions:   Knee Osteoarthritis;   Post-traumatic Osteoarthritis
  Interventions:   Procedure: Unicompartmental Biologic Arthroplasty;   Procedure: Extensive Biologic Arthroplasty
  Sponsor:   University of Missouri-Columbia
  Recruiting
• Interactive Obesity Treatment Approach (iOTA) for Obesity Prevention in Serious Mental Illness

  NCT03695289

  Conditions:   Obesity;   Mentally Ill Persons
  Interventions:   Behavioral: iOTA SMI;   Behavioral: Health Education Control
  Sponsor:   Washington University School of Medicine
  Recruiting
• Training Intrinsic Foot Muscles

  NCT03670563

  Condition:   Muscular Weakness
  Interventions:   Other: Short foot exercise protocol;   Other: Short foot exercise plus NMES
  Sponsor:   St. Louis University
  Completed
• Insomnia Treatment and Problems (the iTAP Study)

  NCT03627832

  Conditions:   Insomnia;   Alcohol; Harmful Use
  Interventions:   Behavioral: Cognitive Behavioral Therapy for Insomnia (CBT-I);   Behavioral: Sleep Hygiene
  Sponsor:   University of Missouri-Columbia
  Recruiting
• Metabolic Effects of Sleep Extension in People With Obesity

  NCT03594994

  Conditions:   Insulin Resistance;   Obesity
  Intervention:   Behavioral: Sleep extension
  Sponsor:   Washington University School of Medicine
  Recruiting
• Improving Cancer Patients' Insurance Choices

  NCT03592433

  Conditions:   Cancer;   Health Literacy;   Health Insurance;   Health Services Accessibility;   Informed Decision Making
  Intervention:   Behavioral: I Can PIC
  Sponsors:   Washington University School of Medicine;   American Cancer Society, Inc.
  Completed
• Effect of Number of Remote Limb Ischemic Conditioning Cycles on Learning Enhancement

  NCT03512041

  Condition:   Healthy, Young Adults
  Interventions:   Behavioral: RLIC - 5 cycles;   Behavioral: RLIC - 4 Cycles;   Behavioral: RLIC - 3 Cycles;   Behavioral: Sham conditioning;   Behavioral: Balance training;   Behavioral: Arm training;   Behavioral: Sequence production training
  Sponsors:   Washington University School of Medicine;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
  Completed
• Remote Limb Ischemic Conditioning to Enhance Learning and Muscle Strength in Healthy Young Adults

  NCT03512028

  Condition:   Healthy, Young Adults
  Interventions:   Behavioral: RLIC;   Behavioral: Sham conditioning;   Behavioral: Muscle strength training;   Behavioral: Driving training;   Behavioral: Balance training
  Sponsors:   Washington University School of Medicine;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
  Completed
• Alcohol Impaired Driving in the Natural Environment

  NCT03503396

  Condition:   Driving Under the Influence
  Interventions:   Behavioral: BAC Driving Feedback/Warning;   Behavioral: No Feedback
  Sponsors:   University of Missouri-Columbia;   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
  Completed
• Low Intensity Physical Activity During Sitting on Glycemic Control and Vascular Function in Obese Individuals

  NCT03419754

  Conditions:   Obesity;   Metabolic Syndrome
  Interventions:   Dietary Supplement: Glucose;   Behavioral: Fidgetting
  Sponsor:   University of Missouri-Columbia
  Recruiting
• Prophylactic Antibiotics Prior to Embryo Transfer (PAPET): RCT

  NCT03386227

  Conditions:   Assisted Reproductive Technology;   Antibiotic Prophylaxis;   Embryo Transfer
  Intervention:   Other: Withholding antibiotic prophylaxis
  Sponsor:   Washington University School of Medicine
  Completed
• Novel Approach To Improving Lactation Support With Mobile Health Technology

  NCT03332108

  Conditions:   Breastfeeding;   Feeding Behavior
  Interventions:   Other: EpxBreastfeeding;   Other: Baby book survey
  Sponsors:   Washington University School of Medicine;   Barnes-Jewish Hospital;   Washington University Institute of Clinical and Translational Sciences
  Completed
• A Biologic Joint Replacement Strategy to Treat Patients With Severe Knee Trauma and Post-Traumatic Knee Osteoarthritis

  NCT03257371

  Condition:   Post-traumatic Osteoarthritis
  Intervention:  
  Sponsor:   James Stannard
  Completed
• Communicating Multiple Disease Risks: A Translation of Risk Prediction Science

  NCT03255291

  Condition:   Healthy Volunteers
  Interventions:   Behavioral: Risk Display App;   Behavioral: Imagery Audio Recording - Sleep;   Other: Survey;   Behavioral: Imagery Audio Recording - Exercise;   Other: Text message reminders;   Other: Text Message Based Survey
  Sponsors:   Washington University School of Medicine;   National Institutes of Health (NIH)
  Completed
• Biological Samples Obtained by Leukapheresis Induced by Two BCG Vaccinations in BCG-naïve Healthy Adults in the US

  NCT03175380

  Condition:   Tuberculosis
  Intervention:   Biological: bacillus Calmette-Guérin
  Sponsor:   Aeras
  Completed
• Reverse Shoulder Replacement: Age 60 or Younger Outcomes

  NCT03148184

  Condition:   Shoulder Arthritis
  Intervention:   Diagnostic Test: shoulder x-ray
  Sponsors:   Washington University School of Medicine;   Zimmer Biomet
  Completed
• Drug Interaction With Proton Pump Inhibitors for Nifedipine ER Tablets

  NCT03100838

  Condition:   Healthy Volunteers
  Interventions:   Drug: Nifedipine 60 MG Extended Release Oral Tablet;   Drug: omeprazole/sodium bicarbonate;   Device: SmartPill (TM)
  Sponsors:   Food and Drug Administration (FDA);   BioPharma Services, Inc
  Completed
• Healthy Patients & Effect of Antibiotics

  NCT03098485

  Conditions:   Microbiota;   Anti-bacterial Agents
  Interventions:   Drug: Levofloxacin;   Drug: Azithromycin;   Drug: Cefpodoxime
  Sponsor:   Washington University School of Medicine
  Active, not recruiting
• Study of Fat Tissue's Ability to Take up Sugar in the Obese Population

  NCT02994459

  Condition:   Glucose Metabolism Disorders
  Intervention:  
  Sponsor:   Washington University School of Medicine
  Recruiting
• Intraoperative Fetal Heart Rate (FHR) Monitoring: a Feasibility Study

  NCT02950896

  Conditions:   Fetal Monitoring;   Labor, Obstetric
  Intervention:   Other: observational fetal heart rate monitoring
  Sponsor:   Washington University School of Medicine
  Terminated
• Testing the Effectiveness of Integrating Relationship Education Into an Existing Workforce Readiness Program

  NCT02829411

  Conditions:   Marriage;   Family Relations
  Interventions:   Behavioral: Workforce Readiness Program;   Behavioral: Relationship education
  Sponsors:   Mathematica Policy Research, Inc.;   Department of Health and Human Services
  Active, not recruiting
• Cognitive Recovery After Electroconvulsive Therapy and General Anesthesia

  NCT02761330

  Conditions:   Depression;   Delirium;   Seizures;   Cognitive Disorders
  Interventions:   Drug: Ketamine;   Procedure: Electroconvulsive Therapy
  Sponsors:   Washington University School of Medicine;   James S McDonnell Foundation
  Active, not recruiting
• Effects of a Calorie Restricted, Very Low Fat Plant-based Diet and Multi-component Exercise Program on Metabolic Health

  NCT02706288

  Conditions:   Obesity;   Insulin Resistance
  Intervention:   Other: Weight loss with very low fat plant-based diet and regular exercise
  Sponsors:   Washington University School of Medicine;   Barnes-Jewish Hospital
  Recruiting
• Complex Effects of Dietary Manipulation on Metabolic Function, Inflammation and Health

  NCT02706262

  Conditions:   Obesity;   Insulin Resistance
  Interventions:   Other: Metabolically abnormal obese - Mediterranean diet;   Other: Metabolically abnormal obese - Low carbohydrate ketogenic diet;   Other: Metabolically abnormal obese - Plant-based, very-low-fat diet
  Sponsors:   Washington University School of Medicine;   Pershing Square Foundation
  Recruiting
• Church-based HIV Screening: Taking It to the Pews

  NCT02529644

  Condition:   HIV
  Interventions:   Behavioral: Taking It to the Pews (Comparison);   Behavioral: Taking It to the Pews (Experimental)
  Sponsors:   University of Missouri, Kansas City;   City of Kansas City Missouri Health Department;   Kansas City CARE Clinic;   RAND;   Children's Mercy Hospital Kansas City;   Caanon Worship Center;   Christian Fellowship Baptist Church;   Friendship Baptist Church;   JayDoc Free Clinic;   Metropolitan Spiritual Church of Christ;   NBC Community Development Corporation;   Concord Fortress of Hope Church;   Victorious Life Church;   Calvary Community Outreach Network
  Active, not recruiting
• Effect of Moderate Weight Loss in Metabolically Abnormal Lean Subjects

  NCT02452567

  Condition:   Weight Loss
  Intervention:   Other: Moderate (8-10%) diet-induced weight loss
  Sponsor:   Washington University School of Medicine
  Active, not recruiting
• Protein Quality on Appetite Control, Reward-driven Eating, & Subsequent Food Intake

  NCT02285907

  Condition:   Appetite and General Nutritional Disorders
  Interventions:   Other: Macronutrient and Fiber Matched BEEF;   Other: Macronutrient and Fiber Matched SOY;   Other: Serving Size Matched BEEF;   Other: Serving Size Matched SOY
  Sponsor:   University of Missouri-Columbia
  Completed
• Insulin Resistance and Reward

  NCT02241603

  Condition:   Obesity
  Intervention:   Behavioral: Weight loss
  Sponsors:   VA Office of Research and Development;   Washington University School of Medicine
  Recruiting
• Medication Enhanced Rapid Therapy

  NCT02099825

  Condition:   Anxiety Disorders
  Intervention:   Drug: d-cycloserine and mifepristone
  Sponsor:   Washington University School of Medicine
  Suspended
• Effect of Skipping Breakfast on Metabolic Function

  NCT02093572

  Conditions:   Skipping Breakfast;   Circadian Rhythms
  Interventions:   Other: 3 standard meals/day;   Other: 2 meals/day (omit breakfast)
  Sponsor:   Washington University School of Medicine
  Active, not recruiting
• Spinal Control During Functional Activities to Improve Low Back Pain Outcomes

  NCT02027623

  Conditions:   Mechanical Low Back Pain;   Chronic Low Back Pain
  Interventions:   Behavioral: Motor skill training;   Behavioral: Strength and flexibility exercise
  Sponsors:   Washington University School of Medicine;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
  Completed
• Upper Extremity Surgery in Spinal Cord Injury

  NCT01899664

  Conditions:   Quadriplegia;   Spinal Cord Diseases;   Spinal Cord Injuries
  Intervention:   Procedure: Nerve Transfer Surgery
  Sponsor:   Washington University School of Medicine
  Active, not recruiting
• Vaginal Progesterone for the Prevention of Preterm Birth in Women With Arrested Preterm Labor

  NCT01840228

  Conditions:   Premature Birth;   Obstetric Labor, Premature
  Intervention:   Drug: Micronized progesterone suppository
  Sponsors:   Washington University School of Medicine;   Thrasher Research Fund
  Terminated
• Alfentanil: Simultaneous Testing Pilot

  NCT01008059

  Condition:   Evaluate Two Paradigms for Simultaneous Assessment of Hepatic and Intestinal CYP3A
  Intervention:   Drug: Alfentanil
  Sponsors:   Washington University School of Medicine;   National Institute of General Medical Sciences (NIGMS)
  Completed
• Glucose and Lipid Metabolism on Antipsychotic Medication

  NCT00515723

  Conditions:   Schizophrenia;   Schizoaffective Disorder;   Type 2 Diabetes Mellitus;   Hyperglycemia
  Interventions:   Drug: risperidone;   Drug: olanzapine;   Drug: quetiapine;   Drug: ziprasidone
  Sponsors:   Washington University School of Medicine;   National Institute of Mental Health (NIMH)
  Completed
• Baricitinib for the Prophylaxis of Graft-Versus-Host Disease After Peripheral Blood Hematopoietic Cell Transplantation

  NCT04131738

  Conditions:   Graft-versus-host-disease;   Graft Vs Host Disease
  Intervention:   Drug: Baricitinib
  Sponsor:   Washington University School of Medicine
  Not yet recruiting
• Characterization of a Portable Solid-State Breath Acetone Testing Device for Real-Time Ketosis Status

  NCT04130724

  Conditions:   Ketogenic Dieting;   Ketosis
  Interventions:   Diagnostic Test: Blood ketone testing;   Diagnostic Test: Breath ketone testing
  Sponsor:   Readout, Inc.
  Enrolling by invitation
• Pregabalin as Part of a Treatment Plan for Ureteral Stent Symptoms After Ureteroscopy

  NCT04122196

  Conditions:   Kidney Stone;   Pain, Postoperative;   Addiction;   Opioid Use
  Interventions:   Drug: Pregabalin 300mg;   Drug: Placebo oral tablet
  Sponsor:   University of Missouri-Columbia
  Not yet recruiting
• Cognition and Magnetic Resonance Imaging of Brain Inflammation in Obesity

  NCT04116229

  Condition:   Obesity
  Interventions:   Procedure: Oral glucose tolerance test;   Behavioral: Cognitive testing;   Procedure: Magnetic resonance imaging
  Sponsors:   Washington University School of Medicine;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
  Recruiting
• Electronic Health Record-Enabled Evidence-Based Smoking Cessation Quality Improvement Implementation Program

  NCT04107857

  Condition:   Smoking Cessation
  Interventions:   Behavioral: ELEVATE enhancement to electronic health record (EHR) to improve cessation counseling offer;   Behavioral: ELEVATE enhancement to electronic health record (EHR) to improve smoking cessation medication offer;   Behavioral: Data Driven Feedback reports
  Sponsors:   Washington University School of Medicine;   National Cancer Institute (NCI);   National Institutes of Health (NIH)
  Not yet recruiting
• LS301 Uptake in Tumors of Patients Undergoing Liver, Pancreas, or Gastric Surgery

  NCT04105062

  Conditions:   Pancreatic Cancer;   Liver Cancer;   Gastric Cancer;   Gastrointestinal Stromal Cancer;   Metastatic Cancer
  Interventions:   Drug: LS301;   Device: Cancer Vision Goggles
  Sponsor:   Washington University School of Medicine
  Not yet recruiting
• Study of Tau Imaging With the Use of [18F]MK-6240 Tracer

  NCT04104659

  Condition:   Alzheimer Disease
  Intervention:   Drug: MK 6240
  Sponsor:   Washington University School of Medicine
  Recruiting
• Evaluation of Increased Absorption of a Curcumin Emulsion (BIOCURC) in Healthy Volunteers

  NCT04103788

  Condition:   Bioavailability
  Interventions:   Dietary Supplement: 95% Curcuminoid Powder;   Dietary Supplement: BIOCURC
  Sponsor:   ESM Technologies, LLC
  Completed
• Metacognitive-Strategy Training in Sub-Acute Stroke

  NCT04099511

  Condition:   Stroke
  Interventions:   Behavioral: Usual Care Occupational Therapy-Outpatient;   Behavioral: Cognitive Orientation to daily Occupational Performance
  Sponsors:   University of Missouri-Columbia;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   University of Michigan
  Not yet recruiting
• Mapping Draining Lymph Nodes in CNS Malignancies

  NCT04096716

  Conditions:   Central Nervous System Neoplasms;   Central Nervous System Tumor
  Intervention:   Drug: Tc-99m tilmanocept
  Sponsor:   Washington University School of Medicine
  Not yet recruiting
• Isatuximab, Bendamustine, and Prednisone in Penta-Refractory Multiple Myeloma

  NCT04083898

  Condition:   Multiple Myeloma
  Interventions:   Biological: Isatuximab;   Drug: Bendamustine;   Drug: Prednisone
  Sponsors:   Washington University School of Medicine;   Sanofi
  Not yet recruiting
• Dental Appliance for Parkinson's Disease

  NCT04082663

  Condition:   Parkinson Disease
  Intervention:   Device: Dental Mouthpiece
  Sponsor:   Washington University School of Medicine
  Recruiting
• A Self-Directed Mindfulness Meditation Intervention in Gynecologic Cancer Patients

  NCT04072406

  Conditions:   Stage III Gynecologic Cancer;   Stage IV Gynecologic Cancer
  Interventions:   Other: Mindfulness meditation;   Other: Usual care packet
  Sponsors:   Washington University School of Medicine;   Washington University Department of Psychological and Brain Sciences
  Recruiting
• Cardiac Rehabilitation for Patients With Lung or Esophageal Cancer Receiving Definitive Radiation Therapy

  NCT04072393

  Conditions:   Lung Cancer;   Esophageal Cancer
  Intervention:   Procedure: Cardiac rehabilitation
  Sponsor:   Washington University School of Medicine
  Not yet recruiting
• RANKL Inhibition and Mammographic Breast Density

  NCT04067726

  Condition:   Dense Breasts
  Interventions:   Drug: Denosumab;   Drug: Placebo;   Drug: Calcium;   Drug: Vitamin D3;   Procedure: Core needle biopsy;   Procedure: Blood draw
  Sponsors:   Washington University School of Medicine;   National Institutes of Health (NIH)
  Recruiting
• Middle Meningeal Artery Embolization for Chronic Subdural Hematoma

  NCT04065113

  Condition:   Chronic Subdural Hematoma
  Interventions:   Procedure: Middle Meningeal Artery Embolization with polyvinyl alcohol particles (PVA);   Procedure: Drainage of Subdural Hematoma
  Sponsor:   Washington University School of Medicine
  Recruiting
• Radiation Dose Intensification With Accelerated Hypofractionated Intensity Modulated Radiation Therapy and Concurrent FOLFOX for Inoperable Esophageal Cancer

  NCT04046575

  Conditions:   Esophagus Cancer;   Esophageal Cancer;   Cancer of the Esophagus
  Interventions:   Radiation: Intensity Modulated Radiation Therapy;   Drug: FOLFOX regimen;   Other: MD Anderson Symptom Inventory (MDASI)-Plus module;   Other: EuroQol (EQ-5D);   Other: SF-12;   Other: MOS Social Support Measure;   Other: CES-D;   Procedure: Blood for ctDNA;   Procedure: Urine for ctDNA;   Procedure: Blood for SCCA
  Sponsor:   Washington University School of Medicine
  Not yet recruiting
• Testing the Safety and Efficacy of Commercial Drug Biktarvy in Subjects Known to Have the 184 Resistance Mutation to a Component in Biktarvy

  NCT04040075

  Condition:   HIV-1-infection
  Intervention:   Drug: Biktarvy Tab
  Sponsor:   Southampton Healthcare, Inc.
  Recruiting
• Pelvic Health and Physical Therapy to Improve Lives of Prostate Cancer Patients Undergoing Prostatectomy

  NCT04027270

  Condition:   Prostate Cancer
  Intervention:   Other: Physical Therapy
  Sponsor:   University of Missouri-Columbia
  Not yet recruiting
• Study to Compare GI Tolerability Following Oral Administration of Bafiertam™ or Tecfidera to Healthy Volunteers

  NCT04022473

  Condition:   Multiple Sclerosis
  Interventions:   Drug: Bafiertam;   Drug: Tecfidera
  Sponsor:   Banner Life Sciences LLC
  Recruiting
• Peer to Peer Programs for Military Suicide Prevention

  NCT04021758

  Condition:   Suicide
  Intervention:   Behavioral: Peer to peer program intervention
  Sponsors:   University of Utah;   Xcelerate Innovations
  Not yet recruiting
• Telemedicine Control Tower for the Post-Anesthesia Care Unit

  NCT04020887

  Condition:   Elective Surgery
  Intervention:   Device: Alertwatch - Interaction
  Sponsor:   Washington University School of Medicine
  Not yet recruiting
• Neoantigen-based Personalized DNA Vaccine in Patients With Newly Diagnosed, Unmethylated Glioblastoma

  NCT04015700

  Condition:   Glioblastoma
  Interventions:   Biological: Personalized neoantigen DNA vaccine supplied by Geneos Therapeutics;   Device: CELLECTRA®2000 EP Device supplied by Geneos Therapeutics;   Drug: Plasmid encoded IL-12
  Sponsor:   Washington University School of Medicine
  Not yet recruiting
• A Wheelchair Propulsion Training Program

  NCT04009187

  Conditions:   Spinal Cord Injuries;   Multiple Sclerosis;   Amputation;   Spina Bifida
  Interventions:   Behavioral: In-person wheelchair propulsion training program;   Behavioral: 30-minute education session
  Sponsor:   Washington University School of Medicine
  Recruiting
• Daily Imaging, Target Identification, and Simulated Computed Tomography-Based Stereotactic Adaptive Radiotherapy Workflow in a Novel Ring Gantry Radiotherapy Device

  NCT04008537

  Conditions:   Cancer of Pancreas;   Cancer of Pelvis;   Cancer of Abdomen;   Cancer of Thorax
  Intervention:   Device: Ring gantry kV-CBCT combined with linear accelerator
  Sponsors:   Washington University School of Medicine;   Varian Medical Systems
  Recruiting
• Exercise for People With Spinal Cord Injury

  NCT04007445

  Condition:   Spinal Cord Injuries
  Interventions:   Behavioral: Formally Directed Group (Exercise Group);   Other: Self-Directed Group (Control Group)
  Sponsors:   Washington University School of Medicine;   The Craig H. Neilsen Foundation
  Recruiting
• ApoGraft for the Prevention of Acute Graft Versus Host Disease in Haploidentical Hematopoietic Cell Transplant Recipients

  NCT04006652

  Conditions:   Acute Graft Versus Host Disease;   Haploidentical Hematopoietic Stem Cell Transplant
  Intervention:   Drug: ApoGraft
  Sponsors:   Washington University School of Medicine;   Cellect Biotechnology
  Not yet recruiting
• Differential Efficacy of Corticosteroid Solutions for Non-Operative Treatment of Digit Flexor Tenosynovitis

  NCT04002037

  Condition:   Trigger Finger
  Interventions:   Drug: Triamcinolone Acetonide 40mg/mL;   Drug: Triamcinolone Acetonide 10mg/mL;   Drug: Dexamethasone 4 mg/ml
  Sponsor:   University of Missouri-Columbia
  Recruiting
• Non-operative vs Surgical Treatment of Isolated Non-Thumb Metacarpal Shaft Fractures

  NCT04001062

  Condition:   Metacarpal Fracture
  Interventions:   Procedure: Surgical Fixation;   Other: Non-Operative Management
  Sponsor:   University of Missouri-Columbia
  Recruiting
• Animal and Plant Proteins and Glucose Metabolism

  NCT03994367

  Conditions:   Metabolic Syndrome;   Metabolic Syndrome, Protection Against;   Glucose Metabolism Disorders
  Interventions:   Other: High animal protein isolate;   Other: High animal protein whole food;   Other: High plant protein isolate;   Other: High plant protein whole food
  Sponsor:   Washington University School of Medicine
  Recruiting
• Smell Changes & Efficacy of Nasal Theophylline

  NCT03990766

  Conditions:   Olfactory Disorder;   Anosmia;   Viral Infection;   Theophylline Causing Adverse Effects in Therapeutic Use;   Smell Disorder
  Interventions:   Drug: Theophylline;   Drug: Saline Nasal
  Sponsor:   Washington University School of Medicine
  Recruiting
• Stay Strong, Stay Healthy Outcomes in Older Adults

  NCT03990415

  Conditions:   Frail Elderly;   Sedentary Lifestyle
  Intervention:   Behavioral: Exercise
  Sponsor:   Dana Duren
  Active, not recruiting
• Development of a Self‐ Management Program for Parents With Spinal Cord Injury and Disease

  NCT03985553

  Condition:   Spinal Cord Injuries
  Intervention:   Behavioral: Parenting Self-Management Program
  Sponsors:   Washington University School of Medicine;   Paralyzed Veterans of America
  Completed
• Ketogenic Diet for Traumatic Brain Injury

  NCT03982602

  Conditions:   Traumatic Brain Injury;   Ketogenic Dieting
  Intervention:   Drug: Ketogenic diet
  Sponsor:   University of Missouri-Columbia
  Recruiting
• MR-Guided High-Intensity Focused Ultrasound in Conjunction With Radiation Therapy for the Treatment of Locally Advanced Cervical Cancer

  NCT03977311

  Condition:   Locally Advanced Cervical Cancer
  Interventions:   Device: Sonalleve Magnetic Resonance-guided High Intensity Focused Ultrasound (MR-HIFU);   Radiation: Radiation therapy
  Sponsor:   Washington University School of Medicine
  Not yet recruiting
• Syndesmosis Ankle Study

  NCT03970603

  Conditions:   Syndesmotic Disruption;   Weight-bearing Status
  Interventions:   Other: Early Weight-Bearing;   Other: Delayed/Late Weight-Bearing
  Sponsor:   Kyle Schweser MD
  Not yet recruiting
• Total Joint Arthroplasty and Sleep

  NCT03968939

  Conditions:   Primary Total Hip Arthroplasty;   Primary Total Knee Arthroplasty
  Interventions:   Drug: Diphenhydramine (Benadryl);   Dietary Supplement: Melatonin;   Behavioral: Sleep Hygiene Education
  Sponsor:   James A. Keeney
  Enrolling by invitation
• Connectomics in Psychiatric Classification

  NCT03967535

  Conditions:   Dementia;   Dementia Alzheimers;   Frontotemporal Dementia;   Pick's Disease With Dementia
  Interventions:   Device: MRI Brain Imaging;   Behavioral: Mental Health Assessment and Computerized Cognitive Test
  Sponsor:   Washington University School of Medicine
  Recruiting
• Nasal Bridles and Repeat Endoscopic Procedures for Endoscopic Nasoenteric Tubes

  NCT03966157

  Condition:   Feeding Disorders
  Intervention:   Device: Nasal Bridle
  Sponsor:   St. Louis University
  Recruiting
• Talus Replacement Registry

  NCT03965143

  Condition:   Avascular Necrosis of the Talus
  Intervention:   Device: 3D talar augmentation
  Sponsor:   Kyle Schweser MD
  Not yet recruiting
• Cladribine Tablets: Collaborative Study to Evaluate Impact On Central Nervous System Biomarkers in Multiple Sclerosis

  NCT03963375

  Conditions:   Multiple Sclerosis;   Multiple Sclerosis, Relapsing-Remitting
  Intervention:   Drug: Cladribine
  Sponsors:   Washington University School of Medicine;   EMD Serono
  Recruiting
• Oral Administration of MB-102 Versus Dual Sugar Testing for Gut Permeability

  NCT03962998

  Condition:   Crohn Disease
  Interventions:   Drug: Lactulose/Rhamnose solution;   Drug: MB-102
  Sponsor:   MediBeacon
  Recruiting
• Ultravision™ System to Facilitate Low Impact Laparoscopic Surgery for Endometriosis

  NCT03956082

  Condition:   Endometriosis
  Intervention:   Device: Ultravision System
  Sponsor:   Mercy Research
  Recruiting
• TSR-042 in Addition to Standard of Care Definitive Radiation for Inoperable Endometrial Cancer

  NCT03955978

  Conditions:   Endometrial Cancer;   Cancer of the Endometrium
  Interventions:   Drug: TSR-042;   Radiation: Brachytherapy;   Procedure: Endometrial biopsy;   Procedure: Blood draw for immune response
  Sponsors:   Washington University School of Medicine;   Tesaro, Inc.
  Not yet recruiting
• Three Arm Rand Trial of HD Light vs Reveal® Cap vs Endocuff Cap for Detection of Colorectal Adenomas (TRACE)

  NCT03952611

  Condition:   Colorectal Adenoma
  Interventions:   Procedure: Colonoscopy;   Device: distal Cap;   Device: Endocuff
  Sponsor:   Midwest Biomedical Research Foundation
  Recruiting
• Effect of Bracing Versus No Bracing in Stable Thoracolumbar Compression and Burst Fractures

  NCT03952182

  Conditions:   Thoracic Fracture;   Lumbar Fracture;   Compression Fracture of Thoracic Vertebral Body;   Compression Fracture of Lumbar Spine;   Burst Fracture of Thoracic Vertebra;   Burst Fracture of Lumbar Vertebra
  Interventions:   Other: Spinal Orthosis (LSO, TLSO);   Other: No orthosis
  Sponsor:   St. Louis University
  Not yet recruiting
• Dietary Protein and Monocyte/Macrophage mTOR Signaling

  NCT03946774

  Condition:   Dietary Protein
  Intervention:   Dietary Supplement: Dietary protein shake
  Sponsor:   Washington University School of Medicine
  Active, not recruiting
• Fluorescence Imaging in Hepatobiliary Surgery

  NCT03946761

  Condition:   Hepatobiliary Surgery
  Interventions:   Drug: Indocyanine Green;   Device: Cancer goggle system
  Sponsor:   Washington University School of Medicine
  Not yet recruiting
• Feasibility of Exercise and Spinal Cord Injury

  NCT03941600

  Condition:   Spinal Cord Injuries
  Interventions:   Behavioral: Community-based Exercise Intervention group (CBE);   Behavioral: Exercise Education Control group (EEG)
  Sponsors:   Washington University School of Medicine;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
  Recruiting
• Cardiac and Renal Biomarkers in Arthroplasty Surgery

  NCT03940651

  Conditions:   Renal Injury;   Anesthesia;   Myocardial Injury;   Arthropathy of Knee;   Arthropathy of Hip
  Interventions:   Drug: Spinal Anesthesia;   Drug: General Anesthetics
  Sponsors:   Washington University School of Medicine;   Abbott;   BioMérieux
  Recruiting
• CNS Tau Kinetics in Healthy Aging and Alzheimer's Disease

  NCT03938870

  Conditions:   Alzheimer's Disease;   Brain Diseases;   Central Nervous System Diseases;   Delirium, Dementia, Amnestic, Cognitive Disorders;   Dementia;   Mental Disorders;   Nervous System Diseases;   Neurodegenerative Diseases;   Tauopathies
  Intervention:   Other: L-Leucine 13C6
  Sponsors:   Washington University School of Medicine;   BrightFocus Foundation;   National Institutes of Health (NIH)
  Recruiting
• ELIRA 2: Safety and Effectiveness of TENS Assisted Weight Loss and Appetite Suppression

  NCT03936699

  Condition:   Weight Loss
  Interventions:   Device: Transcutaneous Nerve Stimulator (TENS);   Behavioral: Diet & Exercise
  Sponsor:   Elira Therapeutics, Inc.
  Recruiting
• ECG for Programming in CRT

  NCT03936608

  Conditions:   Systolic Heart Failure;   Cardiac Resynchronization Therapy;   Electrocardiography
  Interventions:   Device: Programming individualized RV-LV pacing offset to optimize ECG;   Device: Nominally programming CRT device without RV-LV offset
  Sponsor:   Washington University School of Medicine
  Recruiting
• Feasibility of Better Living After Stroke Through Technology

  NCT03935789

  Condition:   Stroke
  Intervention:   Behavioral: BLAST
  Sponsors:   University of Missouri-Columbia;   BrightOutcome, Inc.;   National Institute of Nursing Research (NINR)
  Recruiting
• Translation of Pritikin Program to the Community

  NCT03929198

  Conditions:   Metabolic Syndrome;   Obesity;   Weight Loss;   Hypertension;   Hypercholesterolemia;   Hypertriglyceridemia
  Intervention:   Other: Healthy Lifestyle
  Sponsors:   Washington University School of Medicine;   Pritikin Longevity Center;   Wellmont Health System
  Completed
• Sinemet for Spasticity and Function in Amyotrophic Lateral Sclerosis and Primary Lateral Sclerosis

  NCT03929068

  Conditions:   Amyotrophic Lateral Sclerosis;   Motor Neuron Disease
  Interventions:   Drug: carbidopa-levodopa;   Drug: Placebo Oral Tablet
  Sponsor:   Washington University School of Medicine
  Enrolling by invitation
• Antibiotic Elution in Total Knee Arthroplasty

  NCT03928522

  Condition:   Total Knee Replacement
  Interventions:   Drug: hand mixed vancomycin;   Drug: hand mixed tobramycin;   Device: pre-mixed tobramycin
  Sponsor:   Washington University School of Medicine
  Recruiting
• Perioperative Pregabalin in Ureteroscopy: a Pilot

  NCT03927781

  Conditions:   Nephrolithiasis;   Urolithiasis;   Perioperative/Postoperative Complications;   Pain, Postoperative;   Pain, Acute;   Anesthesia;   Urologic Diseases;   Anesthesia Morbidity
  Intervention:   Drug: Pregabalin 300mg
  Sponsor:   University of Missouri-Columbia
  Enrolling by invitation
• Telemedicine Control Tower for the Operating Room: Navigating Information, Care and Safety

  NCT03923699

  Conditions:   Surgery;   Surgery--Complications;   Perioperative/Postoperative Complications
  Intervention:   Device: Anesthesia Control Tower monitoring
  Sponsors:   Washington University School of Medicine;   National Institute of Nursing Research (NINR)
  Recruiting
• Induction Paclitaxel Followed by Concurrent Paclitaxel and Radiation Therapy for Cutaneous Angiosarcoma

  NCT03921008

  Condition:   Cutaneous Angiosarcoma
  Interventions:   Drug: Paclitaxel;   Radiation: Radiation therapy
  Sponsor:   Washington University School of Medicine
  Recruiting
• Magnetic Resonance-Guided Hypofractionated Adaptive Radiation Therapy With Concurrent Chemotherapy and Consolidation Durvalumab for Inoperable Stage IIB and IIIA Non-small Cell Lung Cancer

  NCT03916419

  Conditions:   Stage IIB Non-Small Cell Lung Carcinoma;   Stage IIIA Non-small Cell Lung Cancer
  Interventions:   Device: ViewRay MR-Linear Accelerator;   Radiation: Radiation therapy;   Drug: Paclitaxel;   Drug: Carboplatin AUC;   Biological: Durvalumab
  Sponsor:   Washington University School of Medicine
  Recruiting
• Optune Device - TT Field Plus Nivolumab and Ipilimumab for Melanoma With Brain Metastasis

  NCT03903640

  Condition:   Melanoma With Brain Metastasis
  Interventions:   Device: Optune;   Biological: Nivolumab;   Biological: Ipilimumab
  Sponsors:   Washington University School of Medicine;   NovoCure Ltd.
  Recruiting
• Study to Evaluate Amyloid in Blood and Imaging Related to Dementia

  NCT03899844

  Conditions:   Alzheimer Disease;   Alzheimer Dementia
  Intervention:   Other: Blood collection, PiB PET/MRI, and cognitive testing
  Sponsor:   Washington University School of Medicine
  Recruiting
• Individualizing Pharmacotherapy for African American Smokers

  NCT03897439

  Condition:   Smoking Cessation
  Interventions:   Drug: Nicotine patch;   Drug: Varenicline Tartrate;   Drug: Bupropion
  Sponsors:   University of Kansas Medical Center;   National Institute on Drug Abuse (NIDA)
  Recruiting
• Single-Dose Study to Evaluate the PKs of Pretomanid in Subjects With Renal Impairment Compared to Subjects With Normal Renal Function

  NCT03896750

  Conditions:   Renal Impairment;   Tuberculosis
  Intervention:   Drug: PA-824
  Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
  Recruiting
• Randomized Controlled Trial of Vaginal Cryotherapy for Pelvic Floor Myofascial Pain

  NCT03885791

  Conditions:   Pelvic Floor Myofascial Pain;   Pelvic Pain;   Myofascial Pain
  Intervention:   Device: vaginal cryotherapy
  Sponsor:   Washington University School of Medicine
  Recruiting
• Liposomal Irinotecan Plus 5-FU / LV Combined With Paricalcitol in Patients With Advanced Pancreatic Cancer Progressed on Gemcitabine-based Therapy

  NCT03883919

  Conditions:   Pancreatic Cancer;   Pancreas Cancer;   Cancer of the Pancreas
  Interventions:   Drug: 5-FU;   Drug: Leucovorin;   Drug: Liposomal Irinotecan;   Drug: Paricalcitol;   Procedure: Serum and plasma blood samples;   Procedure: Tumor biopsy
  Sponsors:   Washington University School of Medicine;   Ipsen
  Recruiting
• Pilot Study of Same-session MR-only Simulation and Treatment With Stereotactic MRI-guided Adaptive Radiotherapy (SMART) for Oligometastases of the Spine

  NCT03878485

  Condition:   Oligometastases of the Spine
  Interventions:   Device: MRIdian Linac System from ViewRay;   Radiation: Stereotactic MRI-guided Adaptive Radiotherapy
  Sponsor:   Washington University School of Medicine
  Not yet recruiting
• ENAC Blockade and Arterial Stiffness

  NCT03837626

  Conditions:   Overweight and Obesity;   Insulin Resistance
  Interventions:   Drug: Placebo - Cap;   Drug: Amiloride Pill
  Sponsor:   University of Missouri-Columbia
  Recruiting
• Same-session MR-only Simulation and Treatment With MRI-guided Adaptive Palliative RadioTherapy

  NCT03824366

  Conditions:   Malignancy;   Metastasis;   Hemoptysis;   Gastrointestinal Bleeding;   Pelvic Bleeding;   Superior Vena Cava Syndrome;   Mediastinal Disease
  Interventions:   Device: Volumetric MR imaging;   Radiation: Radiation therapy
  Sponsor:   Washington University School of Medicine
  Recruiting
• Tolerability and Background Fluorescence of the MediBeacon Transdermal GFR Measurement System

  NCT03810833

  Condition:   Acute Kidney Injury
  Intervention:   Device: Brilliance device sensor
  Sponsor:   MediBeacon
  Not yet recruiting
• CBT-I on Alcohol Treatment Outcomes Among Veterans

  NCT03806491

  Conditions:   Insomnia;   Alcohol Use Disorder
  Interventions:   Behavioral: Cognitive Behavioral Therapy for Insomnia;   Behavioral: Sleep Hygiene Education;   Behavioral: Cognitive Behavioral Therapy for Alcohol Use Disorders
  Sponsors:   University of Missouri-Columbia;   Harry S. Truman Memorial Veterans' Hospital
  Recruiting
• Insomnia Treatment on Heavy Alcohol Use Among Returning Veterans

  NCT03804788

  Conditions:   Insomnia;   Alcohol; Harmful Use
  Interventions:   Behavioral: Cognitive Behavioral Therapy for Insomnia;   Behavioral: Sleep Hygeine
  Sponsors:   University of Missouri-Columbia;   National Institute on Alcohol Abuse and Alcoholism (NIAAA);   American Academy of Sleep Medicine Foundation
  Recruiting
• Rad Predictors for WON

  NCT03801070

  Condition:   Walled Off Pancreatic Necrosis (WON)
  Intervention:   Procedure: endoscopic drainage of walled off pancreatic necrosis
  Sponsors:   Washington University School of Medicine;   University of Oklahoma Medical Center;   Northwestern University Chicago Illinois;   Saint Luke's Hospital University of Missouri-Kansas City
  Completed
• Video Based Directly Observed Therapy for Latent TB

  NCT03783728

  Condition:   Latent Tuberculosis
  Interventions:   Drug: Rifapentine 600 mg orally;   Drug: Isoniazid 900 mg orally;   Drug: Pyridoxine 50 mg orally
  Sponsor:   St. Louis University
  Withdrawn
• Removing Home Hazards for Older Adults in Affordable Housing

  NCT03780777

  Condition:   Accidental Fall
  Intervention:   Behavioral: Home Hazard Removal
  Sponsors:   Washington University School of Medicine;   US Department of Housing and Urban Development
  Enrolling by invitation
• Hand-carried Ultrasound to Assess Hydronephrosis

  NCT03774719

  Conditions:   Hydronephrosis;   Ultrasound;   Acute Kidney Injury
  Intervention:   Device: Hand-carried ultrasound
  Sponsor:   Washington University School of Medicine
  Recruiting
• NEM® + BIOCURC® Versus Placebo in Exercised-induced Joint Pain, Stiffness, & Cartilage Turnover in Healthy Men & Women

  NCT03769857

  Conditions:   Exercise-induced Joint Pain;   Exercise-induced Joint Stiffness;   Exercise-induced Joint Cartilage Turnover
  Interventions:   Dietary Supplement: NEM® + BIOCURC®;   Dietary Supplement: Placebo
  Sponsors:   ESM Technologies, LLC;   QPS Bio-Kinetic
  Completed
• Study of Itacitinib for the Prophylaxis of Graft-Versus-Host Disease and Cytokine Release Syndrome After T-cell Replete Haploidentical Peripheral Blood Hematopoietic Cell Transplantation

  NCT03755414

  Conditions:   Acute Myelogenous Leukemia;   Acute Lymphocytic Leukemia;   Myelodysplastic Syndromes;   Non-Hodgkin Lymphoma;   Hodgkin Disease
  Interventions:   Procedure: Stem cell transplantation;   Drug: Itacitinib;   Other: Functional Assessment of Cancer Therapy-Bone Marrow Transplant (FACT-BMT);   Other: Human Activity Profile
  Sponsors:   Washington University School of Medicine;   Incyte Corporation
  Recruiting
• Sleep and Pain Interventions in Women With Fibromyalgia

  NCT03744156

  Conditions:   Fibromyalgia;   Insomnia;   Chronic Widespread Pain
  Interventions:   Behavioral: Cognitive Behavioral Treatment-Insomnia;   Behavioral: Sleep Hygiene Education
  Sponsors:   University of Missouri-Columbia;   University of Florida;   National Institute of Nursing Research (NINR)
  Recruiting
• Repetitive TMS & Cognitive Training in Adults With Schizophrenia

  NCT03741751

  Conditions:   Schizophrenia Spectrum and Other Psychotic Disorders;   Cognitive Impairment
  Interventions:   Device: rTMS;   Behavioral: Computerized cognitive training
  Sponsor:   Washington University School of Medicine
  Recruiting
• Coxsackie Virus in Pregnancy and Congenital Heart Disease

  NCT03737006

  Condition:   Congenital Heart Disease in Pregnancy
  Intervention:  
  Sponsor:   Washington University School of Medicine
  Recruiting
• Nitrous Oxide- Suicidal Ideation

  NCT03736538

  Conditions:   Major Depressive Disorder;   Depression;   Mood Disorders;   Suicidal Ideation
  Interventions:   Drug: Nitrous Oxide;   Drug: Placebo gas
  Sponsors:   Washington University School of Medicine;   American Foundation for Suicide Prevention
  Enrolling by invitation
• TraceIT Tissue Marker to Mark the Primary Resection Bed Margins of Oropharyngeal Cancers

  NCT03713021

  Condition:   Oropharyngeal Cancer
  Intervention:   Device: TraceIT Tissue Marker
  Sponsor:   Washington University School of Medicine
  Recruiting
• Outcomes of Low-Impact Exercise Program for People With Ankle, Knee, and/or Hip Pain

  NCT03711773

  Conditions:   Osteoarthritis;   Osteoarthritis, Knee;   Osteoarthritis, Hip;   Osteoarthritis Ankle
  Intervention:   Other: Group Physical Therapy Classes
  Sponsor:   University of Missouri-Columbia
  Recruiting
• Remote Telemonitoring to Improve Prehabilitation and Surgical Outcomes of Patients Undergoing Pancreatic Resection

  NCT03706963

  Condition:   Pancreas Disease
  Intervention:   Other: Phone Call
  Sponsor:   Washington University School of Medicine
  Recruiting
• Ramucirumab and Atezolizumab After Progression on Any Immune Checkpoint Blocker in NSCLC

  NCT03689855

  Conditions:   Non-small Cell Lung Cancer;   Non Small Cell Lung Cancer;   NSCLC
  Interventions:   Drug: Ramucirumab;   Drug: Atezolizumab;   Procedure: Peripheral blood draw;   Procedure: Biopsy
  Sponsors:   Washington University School of Medicine;   Eli Lilly and Company
  Recruiting
• rhIL-7-hyFc on Increasing Lymphocyte Counts in Patients With Newly Diagnosed Non-lymphopenic Gliomas Following Radiation and Temzolomide

  NCT03687957

  Condition:   Glioma
  Interventions:   Drug: rhIL-7-hyFc;   Drug: Placebo;   Drug: Temozolomide;   Radiation: Radiation therapy;   Procedure: Blood sample
  Sponsors:   Washington University School of Medicine;   Neoimmune Technologies;   Barnes-Jewish Hospital
  Recruiting
• Promoting Physical Activity in Rural Populations

  NCT03683173

  Condition:   Physical Activity
  Intervention:   Behavioral: Intervention
  Sponsors:   Washington University School of Medicine;   National Cancer Institute (NCI)
  Recruiting
• Glucose Time-In-Range Development Evaluation

  NCT03670017

  Conditions:   ICU;   Dysglycemia
  Intervention:   Device: OptiScanner® 5000 Glucose Monitoring System
  Sponsors:   Washington University School of Medicine;   OptiScan Biomedical Corporation
  Recruiting
• Abemaciclib + Nivolumab in Patients With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma That Progressed or Recurred Within Six Months After Platinum-based Chemotherapy

  NCT03655444

  Condition:   Head and Neck Squamous Cell Carcinoma
  Interventions:   Drug: Abemaciclib;   Drug: Nivolumab;   Procedure: Tumor biopsy;   Procedure: Peripheral blood;   Other: EORTC QLQ-30
  Sponsors:   Washington University School of Medicine;   Eli Lilly and Company
  Recruiting
• Pulsed Abraxane and Radiotherapy for Improving and Maintaining Ambulation After Cancer-Related Cord Compression

  NCT03655080

  Condition:   Cord Compression
  Interventions:   Radiation: Radiation therapy;   Drug: nab-Paclitaxel
  Sponsors:   Washington University School of Medicine;   Celgene
  Recruiting
• Pilon Fracture With Intra-articular Injection of N-Acetylcysteine (Pilon NAC)

  NCT03652753

  Condition:   Pilon Fracture
  Interventions:   Drug: N-acetylcysteine;   Drug: Saline
  Sponsor:   University of Missouri-Columbia
  Active, not recruiting
• Ramucirumab + Pembrolizumab in Patients With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma

  NCT03650764

  Condition:   Head and Neck Squamous Cell Carcinoma
  Interventions:   Drug: Ramucirumab;   Drug: Pembrolizumab;   Other: EORTC QLQ-30;   Other: FACT H&N;   Procedure: Peripheral blood
  Sponsors:   Washington University School of Medicine;   Eli Lilly and Company
  Recruiting
• Sex-related Differences in Arterial Stiffness in Type 2 Diabetics: Role of Uric Acid

  NCT03648996

  Conditions:   Diabetes Mellitus, Type 2;   Hyperuricemia
  Interventions:   Other: Low-fructose diet;   Drug: Allopurinol;   Drug: Placebo
  Sponsor:   University of Missouri-Columbia
  Recruiting
• Response Assessment in SB CD

  NCT03646708

  Condition:   Small Bowel Crohn's Disease
  Intervention:  
  Sponsors:   Washington University School of Medicine;   American College of Gastroenterology
  Recruiting
• Evaluating the Safety and Efficacy of Fractionated Carbon Dioxide Therapy in Postoperative Lower Extremity Wound Healing

  NCT03644849

  Condition:   Leg Ulcer
  Interventions:   Device: CO2RE® (Syneron Candela Corp, Wayland, MA);   Other: Sham laser treatment
  Sponsor:   St. Louis University
  Recruiting
• Hyponatremia Study (Delayed Hyponatremia After Pituitary Surgery)

  NCT03636568

  Conditions:   Hyponatremia;   Hyponatremic;   Pituitary Tumor;   Pituitary;   Surgery
  Intervention:   Other: Fluid Restricted Group
  Sponsor:   Washington University School of Medicine
  Recruiting
• RANKL Inhibition and Breast Tissue Biomarkers

  NCT03629717

  Conditions:   Breast Cancer Prevention;   Mammographic Density
  Interventions:   Procedure: Ultrasound-guided core needle biopsy;   Drug: Denosumab;   Procedure: Blood draw;   Drug: Calcium;   Drug: Vitamin D
  Sponsor:   Washington University School of Medicine
  Completed
• Surgery Followed by Risk-Directed Post-Operative Adjuvant Therapy for HPV-Related Oropharynx Squamous Cell Carcinoma: "The Minimalist Trial (MINT)"

  NCT03621696

  Condition:   HPV Related Oropharyngeal Squamous Cell Carcinoma
  Interventions:   Drug: Cisplatin;   Radiation: Intensity modulated radiation therapy;   Radiation: Intensity modulated proton therapy;   Procedure: Surgery;   Other: FACT-H&N;   Other: MD Anderson Dysphagia Inventory;   Other: University of Michigan Xerostomia Index;   Other: Scale of Subjective Total Taste Acuity;   Other: Neck Dissection Impairment Index
  Sponsor:   Washington University School of Medicine
  Recruiting
• Peak Plantar Pressures While Wearing a Carbon Fiber Off Loading Orthoses

  NCT03618628

  Conditions:   Diabetes Mellitus;   Peripheral Neuropathy;   Orthotic Device
  Intervention:   Device: Carbon Fiber Off Loading Orthosis (CFO)
  Sponsor:   Washington University School of Medicine
  Completed
• Three Fraction Accelerated Partial Breast Irradiation as the Sole Method of Radiation Therapy for Low-risk Stage 0 and I Breast Carcinoma

  NCT03612648

  Conditions:   Breast Carcinoma;   Breast Cancer
  Interventions:   Radiation: Three Fraction Accelerated Partial Breast Irradiation;   Procedure: Partial mastectomy
  Sponsor:   Washington University School of Medicine
  Recruiting
• Chronic Stroke Rehabilitation With Contralesional Brain-Computer Interface

  NCT03611855

  Conditions:   Chronic Stroke;   Hemiparesis
  Interventions:   Device: BCI Rehabilitation;   Other: Range of Motion Therapy
  Sponsors:   Washington University School of Medicine;   Neurolutions, Inc.
  Recruiting
• Feasibility of the Lee Silverman Voice Treatment®-BIG Intervention in Stroke

  NCT03602443

  Condition:   Chronic Stroke
  Interventions:   Behavioral: LSVT®BIG Intervention;   Behavioral: Waitlist Control
  Sponsors:   University of Missouri-Columbia;   American Occupational Therapy Foundation
  Recruiting
• PolyImmune {Durvalumab (MEDI4736) and Tremelimumab} & Vaccine Orchestrated Treatment for Patients With Advanced/Metastatic Renal Cell Carcinoma

  NCT03598816

  Condition:   Renal Cell Carcinoma
  Interventions:   Drug: Durvalumab;   Drug: Tremelimumab;   Device: TDS-IM System;   Biological: Neoantigen DNA Vaccine;   Procedure: Research blood draw
  Sponsors:   Washington University School of Medicine;   MedImmune LLC
  Not yet recruiting
• Functional Imaging Reserve in NeuroHIV

  NCT03596268

  Condition:   HIV
  Interventions:   Diagnostic Test: Imaging;   Diagnostic Test: Serum Laboratory Tests;   Diagnostic Test: Lumbar Puncture
  Sponsors:   Washington University School of Medicine;   National Institutes of Health (NIH);   University of Missouri, St. Louis;   Temple University;   University of California, San Diego
  Recruiting
• Prospective Memory Training in Parkinson Disease

  NCT03582670

  Condition:   Parkinson Disease
  Interventions:   Behavioral: Strategy Training;   Behavioral: Process Training;   Behavioral: Control Group
  Sponsor:   Washington University School of Medicine
  Active, not recruiting
• Tofacitinib for Inflammatory Eye Disease

  NCT03580343

  Conditions:   Uveitis;   Scleritis
  Intervention:   Drug: tofacitinib
  Sponsor:   Washington University School of Medicine
  Active, not recruiting
• Hyperosmolar Saline Irrigation Fluid in Arthroscopic Knee Surgery

  NCT03564886

  Condition:   Arthroscopic Knee Surgery
  Interventions:   Drug: Hyperosmolar Saline;   Drug: Normal saline
  Sponsor:   University of Missouri-Columbia
  Active, not recruiting
• Effect of Occupational Therapy in Promoting Medication Adherence

  NCT03551925

  Conditions:   Hypertension;   Diabete Type 2
  Interventions:   Behavioral: Treatment as Usual Plus Occupational Therapy;   Behavioral: Treatment as Usual
  Sponsors:   University of Indianapolis;   University of Missouri, Kansas City;   Missouri State University
  Completed
• VAscular Closure for Cardiac Ablation Registry (VACCAR)

  NCT03546439

  Condition:   Atrial Fibrillation
  Intervention:  
  Sponsors:   Sanjaya Gupta;   Abbott Medical Devices
  Recruiting
• Human CNS Tau Kinetics in Tauopathies

  NCT03545126

  Conditions:   Progressive Supranuclear Palsy (PSP);   Corticobasal Degeneration (CBD);   Frontotemporal Dementia (FTD MAPT Mutation)
  Intervention:   Other: 13C6 Leucine
  Sponsors:   Washington University School of Medicine;   Association of Frontotemporal Degeneration;   Tau Consortium
  Recruiting
• Intermittent Fasting in Multiple Sclerosis

  NCT03539094

  Condition:   Relapsing Remitting Multiple Sclerosis
  Intervention:   Other: Intermittent fasting
  Sponsor:   Washington University School of Medicine
  Recruiting
• Combinatorial Pharmacogenomics Testing in Treatment-Naïve Major Depressive Disorder

  NCT03537547

  Conditions:   Major Depressive Disorder;   Depression;   Depressive Disorder;   Depressive Episode;   Depression, Unipolar
  Interventions:   Other: GeneSight Psychotropic test;   Drug: FDA-approved antidepressant or antipsychotic treatment
  Sponsors:   Washington University School of Medicine;   AssureRx Health, Inc.
  Recruiting
• Epacadostat in Combination With Radiation Therapy and Avelumab in Patients With Recurrent Gliomas

  NCT03532295

  Conditions:   Glioma;   Glioblastoma
  Interventions:   Drug: Epacadostat;   Drug: Avelumab;   Drug: Bevacizumab;   Radiation: Radiation therapy;   Procedure: Peripheral blood draw
  Sponsors:   Washington University School of Medicine;   Incyte Corporation
  Not yet recruiting
• Initial Management of Patients Receiving a Single Shock (IMPRESS)

  NCT03531502

  Condition:   Ventricular Tachycardia
  Interventions:   Procedure: Ventricular Tachycardia Ablation;   Other: Standard Medical Therapy;   Procedure: Non-Invasive Programmed Stimulation (NIPS)
  Sponsors:   Sanjaya Gupta;   Medtronic
  Recruiting
• Epidural Methadone in Healthy Volunteers

  NCT03525509

  Condition:   Pain, Acute
  Interventions:   Drug: Methadone hydrochloride;   Drug: Morphine Sulfate
  Sponsor:   simon.haroutounian
  Completed
• Epacadostat (INCB024360) Added to Preoperative Chemoradiation in Patients With Locally Advanced Rectal Cancer

  NCT03516708

  Condition:   Rectal Cancer
  Interventions:   Drug: Epacadostat;   Procedure: Tumor biopsy;   Procedure: Peripheral blood draw
  Sponsors:   Washington University School of Medicine;   Incyte Corporation
  Not yet recruiting
• Better Outcomes for Anticoagulation Treatment Through Observation of Atrial Rhythm

  NCT03515083

  Condition:   Non-valvular Atrial Fibrillation
  Intervention:   Device: Alive Cor Kardia mobile electrocardiogram monitor
  Sponsors:   Sanjaya Gupta;   Bristol-Myers Squibb;   AliveCor
  Recruiting
• Vorolanib (X-82) Combined With Checkpoint Inhibitors in Patients With Solid Tumors

  NCT03511222

  Conditions:   Solid Tumor;   Hepatocellular Carcinoma;   Gastric Cancer;   Gastroesophageal Junction Adenocarcinoma
  Interventions:   Drug: Vorolanib;   Drug: Nivolumab;   Drug: Pembrolizumab;   Procedure: Peripheral blood draw
  Sponsors:   Washington University School of Medicine;   Xcovery Holding Company, LLC
  Recruiting
• Evaluation of the Bowel Cleansing in Hospitalized Patients Using Pure-Vu System

  NCT03503162

  Conditions:   Gastrointestinal Disease;   Colorectal Cancer
  Intervention:   Device: Pure-Vu System
  Sponsor:   Motus GI Medical Technologies Ltd
  Completed
• Effect of SB CD on Chylomicron

  NCT03496818

  Condition:   Crohn Disease
  Intervention:  
  Sponsor:   Washington University School of Medicine
  Recruiting
• BMS-813160 With Nivolumab and Gemcitabine and Nab-paclitaxel in Borderline Resectable and Locally Advanced Pancreatic Ductal Adenocarcinoma (PDAC)

  NCT03496662

  Condition:   Pancreatic Ductal Adenocarcinoma
  Interventions:   Drug: BMS-813160;   Drug: Nivolumab;   Drug: Gemcitabine;   Drug: Nab-paclitaxel;   Procedure: Biopsy;   Procedure: Peripheral blood
  Sponsors:   Washington University School of Medicine;   Bristol-Myers Squibb;   Barnes-Jewish Hospital;   National Institutes of Health (NIH);   National Cancer Institute (NCI)
  Recruiting
• Optimizing CRT With ECGI

  NCT03492788

  Conditions:   Heart Failure, Systolic;   Left Bundle-Branch Block
  Interventions:   Other: ECGI-optimized VV-offset;   Other: Zero VV-offset
  Sponsors:   Washington University School of Medicine;   American College of Cardiology
  Terminated
• PET Imaging CCR2 in Lung Inflammation

  NCT03492762

  Condition:   Lung Inflammation
  Intervention:   Drug: 64Cu-DOTA-ECL1i
  Sponsor:   Washington University School of Medicine
  Recruiting
• A Novel Transition Program to Reduce Disability After Stroke

  NCT03485820

  Conditions:   Ischemic Stroke;   Hemorrhagic Stroke
  Interventions:   Behavioral: COMPASS;   Behavioral: Stroke education
  Sponsors:   Washington University School of Medicine;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
  Recruiting
• Proton Beam Therapy in the Treatment of Esophageal Cancer

  NCT03482791

  Conditions:   Esophagus Cancer;   Esophageal Cancer;   Cancer of the Esophagus
  Interventions:   Radiation: Proton beam therapy;   Other: Patient-Reported Outcome Measures
  Sponsor:   Washington University School of Medicine
  Recruiting
• Psychological Services Integration in Gynecological Oncology Clinics

  NCT03481127

  Condition:   Gynecologic Oncology Patient
  Interventions:   Behavioral: Integrated psychological care;   Other: Surveys;   Procedure: Blood draw;   Procedure: Fresh tissue from ovary
  Sponsors:   Washington University School of Medicine;   Barnes-Jewish Hospital
  Completed
• Dosing of Ketorolac in the Emergency Department

  NCT03464461

  Condition:   Acute Pain
  Intervention:   Drug: Ketorolac
  Sponsor:   University of Missouri-Columbia
  Recruiting
• Arm Exercise Versus Pharmacologic Stress Testing for Clinical Outcome

  NCT03449888

  Condition:   Veterans Referred to the St. Louis VAMC Stress Tes
  Interventions:   Procedure: Regadenoson myocardial perfusion imaging stress test;   Procedure: Arm exercise electrocardiographic stress test;   Procedure: Treadmill electrocardiographic stress test;   Procedure: Coronary artery calcium score and cardiac computed tomographic angiography
  Sponsors:   VA Office of Research and Development;   VA St. Louis Health Care System
  Recruiting
• Helping Empower Liver and Kidney Patients

  NCT03426787

  Conditions:   Hepatitis C;   Chronic Kidney Diseases;   Patient Education
  Intervention:   Behavioral: Decision Aid
  Sponsors:   Washington University School of Medicine;   Merck Sharp & Dohme Corp.
  Completed
• Safety and Efficacy of 21 Gy for High Dose Rate (HDR) Prostate Brachytherapy

  NCT03424850

  Conditions:   Prostate Cancer;   Prostate Neoplasm
  Intervention:   Radiation: HDR brachytherapy
  Sponsor:   Washington University School of Medicine
  Recruiting
• Evaluation of Attenuation Correction Accuracy in Positron Emission Tomography-Magnetic Resonance Imaging (PET-MRI)

  NCT03423407

  Condition:   PET/CT
  Intervention:   Device: Positron Emission Tomography-Magnetic Resonance Imaging (PET-MRI)
  Sponsor:   Washington University School of Medicine
  Recruiting
• Adipose Tissue Inflammation in Individuals Undergoing Bariatric Surgery

  NCT03419273

  Conditions:   Obesity, Morbid;   Bariatric Surgery Candidate
  Intervention:   Procedure: bariatric surgery
  Sponsor:   University of Missouri-Columbia
  Completed
• Management of Malignant Pleural Effusions Using an Indwelling Tunneled Pleural Catheter and Non-Vacuum Collection System

  NCT03414905

  Condition:   Malignant Pleural Effusion
  Interventions:   Device: Aspira Catheter;   Procedure: Ultrasound
  Sponsor:   Washington University School of Medicine
  Recruiting
• Obstructive Sleep Apnea and Glucose Metabolism

  NCT03408613

  Conditions:   Sleep Apnea;   Glucose Metabolism Disorders
  Interventions:   Procedure: Positive Airway Pressure;   Procedure: Supplemental Oxygen;   Procedure: Sham
  Sponsor:   Washington University School of Medicine
  Recruiting
• Dual-Energy CT on Plan Quality, Dose-delivery Accuracy, and Simulated Patient Outcomes for Locally Advanced Lung and Brain Tumor Patients Treated With Proton Therapy

  NCT03403361

  Conditions:   Lung Cancer;   Brain Cancer
  Interventions:   Device: Siemens Somatom Definition Edge;   Device: Philips Brilliance Big Bore CT/simulator
  Sponsors:   Washington University School of Medicine;   National Cancer Institute (NCI)
  Recruiting
• Nutraceutical Efficacy for rUTI

  NCT03395288

  Condition:   Urinary Tract Infections
  Intervention:   Drug: D-Mannose
  Sponsor:   Washington University School of Medicine
  Recruiting
• Los Tres Paso: Neoadjuvant Palbociclib Monotherapy, Concurrent Chemoradiation Therapy, Adjuvant Palbociclib Monotherapy in Patients With p16INK4a Negative, HPV-Unrelated Head and Neck Squamous Cell Carcinoma

  NCT03389477

  Condition:   Head and Neck Squamous Cell Carcinoma
  Interventions:   Drug: Palbociclib;   Drug: Cetuximab;   Drug: Cisplatin;   Radiation: Intensity-Modulated Radiation Therapy;   Procedure: Tumor biopsy;   Procedure: Peripheral blood draw;   Other: European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30
  Sponsors:   Washington University School of Medicine;   Pfizer
  Recruiting
• TOX NEG Trial: Clostridium Difficile Diagnosis and Treatment

  NCT03388268

  Conditions:   Clostridium Difficile Infection;   Diarrhea
  Interventions:   Drug: Oral Vancomycin;   Drug: Placebo;   Device: Toxin enzyme immunoassay;   Device: Nuceleic acid amplification test
  Sponsor:   Washington University School of Medicine
  Enrolling by invitation
• Pevonedistat in Combination With Ruxolitinib for Treatment of Patients With Myelofibrosis

  NCT03386214

  Condition:   Myelofibroses
  Interventions:   Drug: Pevonedistat;   Drug: Ruxolitinib;   Procedure: Peripheral blood draw;   Procedure: Skin biopsy
  Sponsors:   Washington University School of Medicine;   Takeda
  Recruiting
• PRISM-GENOMICS-Smoking Cessation for Patients With Coronary Artery Disease Undergoing Cardiac Catheterization or Having a Heart Attack at Barnes Hospital in St. Louis Mo

  NCT03383224

  Conditions:   Coronary Artery Disease;   Smoking Cessation
  Interventions:   Other: genotype-guided therapy;   Drug: Nicotine patch;   Behavioral: Smoking cessation counseling
  Sponsor:   Washington University School of Medicine
  Recruiting
• Specifying Interventions From the Sickle Cell Disease Implementation Consortium (SCDIC)

  NCT03380351

  Condition:   Anemia, Sickle Cell
  Interventions:   Behavioral: SCDIC interventions;   Behavioral: SCDIC control groups
  Sponsors:   Washington University School of Medicine;   National Heart, Lung, and Blood Institute (NHLBI)
  Recruiting
• How Microbes and Metabolism May Predict Skin Cancer Immunotherapy Outcomes

  NCT03370861

  Conditions:   Autoimmunity;   Melanoma;   Merkel Cell Carcinoma;   Squamous Cell Carcinoma of the Skin;   Basal Cell Carcinoma;   Skin Cancer
  Intervention:   Biological: Immunotherapy
  Sponsor:   Washington University School of Medicine
  Recruiting
• Fecal Microbiota Transplantation (FMT) for MDRO UTI

  NCT03367910

  Condition:   Urinary Tract Infections
  Intervention:   Drug: Fecal microbiota transplant
  Sponsors:   Washington University School of Medicine;   Centers for Disease Control and Prevention;   University of Pennsylvania;   Duke University;   Rush University;   Rebiotix Inc.
  Enrolling by invitation
• Optimizing Decision Making About Breast Reconstruction After Mastectomy: A Patient-Centered Approach

  NCT03346161

  Condition:   Breast Cancer
  Interventions:   Other: Usual care American Society of Plastic Surgeons booklet "Breast Reconstruction";   Other: Decision tool;   Other: Usual Care Group - Outcome Measures;   Other: Decision Group - Outcome Measures;   Other: Demographic and Background Questions
  Sponsor:   Washington University School of Medicine
  Completed
• Diffusion MRI in Cervical Spondylotic Myelopathy (CSM)

  NCT03296592

  Condition:   Cervical Spondylotic Myelopathy
  Intervention:   Diagnostic Test: MRI with DBSI technology
  Sponsors:   Washington University School of Medicine;   National Institute of Neurological Disorders and Stroke (NINDS)
  Recruiting
• Postoperative Delirium: EEG Markers of Sleep and Wakefulness

  NCT03291626

  Condition:   Postoperative Delirium
  Intervention:  
  Sponsor:   Washington University School of Medicine
  Recruiting
• "Hyaluronan" Formulation for Type 2 Diabetic Patients With Dry Mouth

  NCT03281486

  Conditions:   Dry Mouth;   Xerostomia;   Type 2 Diabetics
  Interventions:   Device: HA formulation Oral Spray;   Device: Placebo
  Sponsor:   You First Services
  Active, not recruiting
• Impact of Component Design and Fixation in Total Knee Arthroplasty

  NCT03272178

  Condition:   Arthroplasties, Knee Replacement
  Interventions:   Device: Depuy total knee implant;   Device: Triathlon total knee implant
  Sponsors:   Washington University School of Medicine;   Stryker Nordic
  Enrolling by invitation
• Effect of Weight Loss on Body Composition and Metabolic Function in Women With Lipedema

  NCT03271034

  Conditions:   Lipedema;   Metabolism
  Intervention:   Dietary Supplement: Mediterranean diet
  Sponsor:   Washington University School of Medicine
  Recruiting
• Mindful Movement in Women Receiving Adjuvant or Neoadjuvant Therapy for Breast Cancer

  NCT03262831

  Conditions:   Breast Cancer;   Cancer of Breast
  Interventions:   Other: Yoga;   Procedure: Blood draw;   Behavioral: FACT-G questionnaire;   Procedure: Weight measurement;   Behavioral: Recent Physical Activity Questionnaire;   Behavioral: NHANES Food Questionnaire
  Sponsors:   Washington University School of Medicine;   BJH Foundation
  Completed