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• Building and Pilot Testing a Couples-based Smartphone Systems to Address Alcohol Use Disorder

  NCT04059549

  Conditions:   Alcohol Use Disorder;   Couples;   Behavior, Addictive
  Interventions:   Behavioral: PartnerCHESS;   Behavioral: A-CHESS
  Sponsors:   University of Wisconsin, Madison;   University of Massachusetts, Worcester
  Recruiting
• Treating Chronic Pain in Buprenorphine Patients in Primary Care Settings

  NCT03698669

  Condition:   Opioid-Related Disorders
  Interventions:   Behavioral: Treating Opioid Patients' Pain and Sadness (TOPPS);   Behavioral: Health Education (HE)
  Sponsors:   Boston University;   National Institute on Drug Abuse (NIDA)
  Recruiting
• A Phase 3 Study to Confirm the Efficacy and Safety of Linzagolix to Treat Endometriosis-associated Pain

  NCT03986944

  Condition:   Endometriosis
  Interventions:   Drug: Placebo linzagolix tablets and Placebo Add-back capsule;   Drug: Placebo linzagolix and linzagolix tablets and Placebo Add-back capsule;   Drug: Placebo linzagolix and linzagolix tablets and Add-back capsule
  Sponsor:   ObsEva SA
  Recruiting
• Study of the Safety and Efficacy of Elagolix in Women With Polycystic Ovary Syndrome

  NCT03951077

  Condition:   Polycystic Ovary Syndrome
  Interventions:   Drug: Elagolix;   Drug: Placebo
  Sponsor:   AbbVie
  Recruiting
• A Study to Evaluate the Safety and Efficacy of Elagolix for the Management of Heavy Menstrual Bleeding Associated With Uterine Fibroids in Premenopausal Women

  NCT03886220

  Condition:   Uterine Fibroids
  Interventions:   Drug: Elagolix;   Drug: Placebo
  Sponsor:   AbbVie
  Recruiting
• AMPLATZER PFO Occluder Post Approval Study

  NCT03309332

  Conditions:   Stroke;   Patent Foramen Ovale
  Intervention:   Device: AMPLATZER™ PFO Occluder
  Sponsor:   Abbott Medical Devices
  Recruiting
• Project MIMIC (Maximizing Implementation of Motivational Incentives in Clinics)

  NCT03931174

  Condition:   Opioid-use Disorder
  Interventions:   Behavioral: Addiction Technology Transfer Center (ATTC) Training Strategy;   Behavioral: Enhanced Addiction Technology Transfer Center (E-ATTC) Training Strategy
  Sponsors:   Brown University;   RTI International;   University of Washington;   UConn Health
  Recruiting
• A Phase II Study in Patients With Moderate to Severe Active Crohn's Disease

  NCT03677648

  Condition:   Crohn's Disease
  Interventions:   Drug: SHR0302;   Drug: Placebos
  Sponsor:   Reistone Biopharma Company Limited
  Recruiting
• A Phase II Study in Patients With Moderate to Severe Active Ulcerative Colitis.

  NCT03675477

  Condition:   Ulcerative Colitis
  Interventions:   Drug: SHR0302;   Drug: Placebos
  Sponsor:   Reistone Biopharma Company Limited
  Recruiting
• A Study of Tirzepatide (LY3298176) Versus Semaglutide Once Weekly as Add-on Therapy to Metformin in Participants With Type 2 Diabetes

  NCT03987919

  Condition:   Type 2 Diabetes
  Interventions:   Drug: Tirzepatide;   Drug: Semaglutide
  Sponsor:   Eli Lilly and Company
  Recruiting
• Study Investigating the Effect of 4 Doses of RPL554 Given in Addition to Tiotropium to Patients With COPD

  NCT03937479

  Condition:   COPD
  Interventions:   Drug: Ensifentrine (formerly RPL554) 0.375 mg twice daily plus placebo, in addition to tiotropium;   Drug: Ensifentrine (formerly RPL554) 0.75 mg twice daily plus placebo, in addition to tiotropium;   Drug: Ensifentrine (formerly RPL554) 1.5 mg twice daily plus placebo, in addition to tiotropium;   Drug: Ensifentrine (formerly RPL554) 3.0 mg twice daily plus placebo, in addition to tiotropium;   Drug: Ensifentrine (formerly RPL554) placebo twice daily, in addition to tiotropium
  Sponsors:   Verona Pharma plc;   Iqvia Pty Ltd;   LGC Limited
  Recruiting
• A Study of MD-7246 to Treat Abdominal Pain in Patients With Diarrhea-predominant Irritable Bowel Syndrome

  NCT03931785

  Condition:   Irritable Bowel Syndrome With Diarrhea (IBS-D)
  Interventions:   Drug: MD-7246;   Drug: Placebo
  Sponsors:   Ironwood Pharmaceuticals, Inc.;   Allergan Sales, LLC
  Recruiting
• A Study of Baricitinib (LY3009104) in Participants With Rheumatoid Arthritis

  NCT03915964

  Condition:   Rheumatoid Arthritis
  Interventions:   Drug: Baricitinib;   Drug: TNF Inhibitor
  Sponsors:   Eli Lilly and Company;   Incyte Corporation
  Recruiting
• Safety, Tolerability, and Efficacy of Cilofexor in Non-Cirrhotic Adults With Primary Sclerosing Cholangitis

  NCT03890120

  Condition:   Primary Sclerosing Cholangitis
  Interventions:   Drug: Cilofexor;   Drug: Placebo
  Sponsor:   Gilead Sciences
  Recruiting
• A Study of Tirzepatide (LY3298176) Once a Week Versus Insulin Glargine Once a Day in Participants With Type 2 Diabetes and Increased Cardiovascular Risk

  NCT03730662

  Condition:   Type 2 Diabetes Mellitus
  Interventions:   Drug: Tirzepatide;   Drug: Insulin Glargine
  Sponsor:   Eli Lilly and Company
  Recruiting
• A Maintenance Study of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis

  NCT03524092

  Condition:   Ulcerative Colitis
  Interventions:   Drug: Mirikizumab;   Drug: Placebo
  Sponsor:   Eli Lilly and Company
  Recruiting
• An Induction Study of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis (LUCENT 1)

  NCT03518086

  Condition:   Ulcerative Colitis
  Interventions:   Drug: Mirikizumab;   Drug: Placebo
  Sponsor:   Eli Lilly and Company
  Recruiting
• A Study to Evaluate the Effect of Testosterone Replacement Therapy (TRT) on the Incidence of Major Adverse Cardiovascular Events (MACE) and Efficacy Measures in Hypogonadal Men ( TRAVERSE )

  NCT03518034

  Conditions:   Hypogonadism;   Cardiovascular Diseases
  Interventions:   Drug: Testosterone;   Drug: Placebo
  Sponsors:   AbbVie;   Acerus Pharmaceuticals Corporation;   Allergan Sales, LLC;   Endo Pharmaceuticals;   Upsher-Smith Laboratories
  Recruiting
• Study to Evaluate the Efficacy and Safety of Tezepelumab in Reducing Oral Corticosteroid Use in Adults With Oral Corticosteroid Dependent Asthma

  NCT03406078

  Condition:   Asthma
  Interventions:   Biological: Tezepelumab;   Other: Placebo
  Sponsors:   AstraZeneca;   Amgen
  Recruiting
• QP ExCELs: MultiPole Pacing (MPP) Sub-Study

  NCT03155724

  Condition:   Heart Failure
  Intervention:   Device: MultiPole Pacing
  Sponsor:   Biotronik, Inc.
  Recruiting
• Strategic Management to Optimize Response To Cardiac Resynchronization Therapy

  NCT03089281

  Condition:   Heart Failure
  Intervention:   Device: CRT-D
  Sponsor:   Boston Scientific Corporation
  Recruiting
• Randomized Placebo-controlled Trial of FCM as Treatment for Heart Failure With Iron Deficiency

  NCT03037931

  Conditions:   Heart Failure;   Iron-deficiency
  Interventions:   Drug: Ferric carboxymaltose;   Drug: Placebos
  Sponsors:   American Regent, Inc.;   Duke Clinical Research Institute
  Recruiting
• Assessment of Primary Prevention Patients Receiving An ICD - Systematic Evaluation of ATP

  NCT02923726

  Condition:   Sudden Cardiac Death
  Interventions:   Device: Arm 1 (ATP+Shock);   Device: Arm 2 (shock only)
  Sponsors:   Boston Scientific Corporation;   ICON plc
  Recruiting
• Sentus QP - Extended CRT Evaluation With Quadripolar Left Ventricular Leads

  NCT02290028

  Condition:   Heart Failure
  Intervention:   Device: Sentus QP left ventricular lead
  Sponsors:   Biotronik SE & Co. KG;   Biotronik, Inc.
  Recruiting
• Standard or Comprehensive Radiation Therapy in Treating Patients With Early-Stage Breast Cancer Previously Treated With Chemotherapy and Surgery

  NCT01872975

  Conditions:   Stage IB Breast Cancer;   Stage II Breast Cancer
  Interventions:   Radiation: regional nodal XRT;   Radiation: chestwall XRT;   Radiation: WBI
  Sponsors:   NSABP Foundation Inc;   National Cancer Institute (NCI);   Radiation Therapy Oncology Group
  Recruiting
• Etrasimod Versus Placebo for the Treatment of Moderately to Severely Active Ulcerative Colitis

  NCT03945188

  Condition:   Ulcerative Colitis
  Interventions:   Drug: Etrasimod;   Drug: Placebo
  Sponsor:   Arena Pharmaceuticals
  Recruiting
• Safety, Tolerability, and Immunogenicity of V114 in Healthy Infants (V114-029)

  NCT03893448

  Conditions:   Pneumococcal Infections;   Pneumococcal Vaccines
  Interventions:   Biological: V114;   Biological: Prevnar 13™;   Biological: RotaTeq™;   Biological: Pentacel™;   Biological: RECOMBIVAX HB™;   Biological: VAQTA™;   Biological: M-M-R™;   Biological: VARIVAX™;   Biological: HIBERIX™
  Sponsor:   Merck Sharp & Dohme Corp.
  Recruiting