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• Timed Exercise Study

  NCT04097886

  Condition:   Circadian Timing - Exercise
  Interventions:   Other: Morning Exercise;   Other: Evening Exercise
  Sponsor:   Julie Pendergast
  Completed
• Trial of Neurostimulation and Blood Flow Restriction for PFPS in Active Duty

  NCT04086615

  Condition:   Patellofemoral Pain Syndrome
  Interventions:   Device: NMES and exercise supplemented with high BFR;   Device: NMES and exercise supplemented with low BFR
  Sponsors:   University of Tennessee;   Blanchfield Army Community Hospital
  Not yet recruiting
• Neurobehavioral Mechanisms of Choice in Opioid Use Disorder

  NCT03958474

  Condition:   Opioid Use Disorder
  Intervention:   Drug: Oxycodone
  Sponsor:   Joshua A. Lile, Ph.D.
  Recruiting
• Behavioral Effects of Drugs (Inpatient): 38

  NCT03954938

  Condition:   Cocaine Use, Unspecified
  Interventions:   Behavioral: Craving Manipulation;   Drug: Cocaine;   Drug: Placebo
  Sponsor:   William Stoops
  Recruiting
• Suvorexant and Cocaine

  NCT03937986

  Condition:   Cocaine Use Disorder
  Interventions:   Drug: Suvorexant;   Drug: Cocaine;   Drug: Placebo oral capsule
  Sponsors:   William Stoops;   National Institute on Drug Abuse (NIDA)
  Recruiting
• Assessment of Gut Absorption of Experimental Medication BMS-986165 in Healthy Males

  NCT03873415

  Condition:   Psoriasis
  Intervention:   Drug: BMS-986165
  Sponsor:   Bristol-Myers Squibb
  Completed
• Transvaginal Ultrasound: Preterm Birth in Appalachia

  NCT03833284

  Condition:   Preterm Birth
  Interventions:   Behavioral: Participant Barriers to TVU Screening;   Behavioral: Provider Barriers to TVU Screening
  Sponsor:   Niraj Chavan
  Recruiting
• Opioid and Cannabinoid Interactions

  NCT03705559

  Conditions:   Marijuana Usage;   Opioid Use
  Interventions:   Drug: Vaporized Marijuana;   Drug: Opioid Agonist
  Sponsor:   Shanna Babalonis, PhD
  Recruiting
• Marijuana Effects on Simulated Driving Performance

  NCT03699540

  Conditions:   Cannabis;   Cannabis Use;   Marijuana;   Marijuana Usage;   Alcohol Drinking
  Interventions:   Drug: Marijuana;   Drug: Alcohol
  Sponsor:   Shanna Babalonis, PhD
  Recruiting
• Behavioral Effects of Drugs: Inpatient (36) (Alcohol, Duloxetine, and Methylphenidate)

  NCT03575403

  Condition:   Alcohol Use Disorder
  Interventions:   Drug: Alcohol;   Drug: Placebos;   Drug: Duloxetine;   Drug: Methylphenidate
  Sponsors:   Craig Rush;   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
  Recruiting
• Neural Correlates of Self-regulation on Academic Functioning

  NCT03549377

  Condition:   Self-Control
  Intervention:   Behavioral: Deception
  Sponsor:   Alexander Vazsonyi
  Completed
• Behavioral Effects of Drugs: Inpatient (35)

  NCT03519022

  Condition:   Cocaine Use Disorder
  Interventions:   Drug: Cocaine;   Drug: Placebo oral capsule;   Drug: Methylphenidate
  Sponsors:   Craig Rush;   National Institute on Drug Abuse (NIDA)
  Completed
• Evidence-based Educational Materials and Local Resources for Improving Exercise-related Outcomes During Pregnancy

  NCT03504267

  Conditions:   Pregnancy Related;   Obesity
  Intervention:   Other: Physical Activity Education and Resources
  Sponsor:   Western Kentucky University
  Completed
• Subacute Low Back Pain in Active Duty

  NCT03502187

  Condition:   Subacute Low Back Pain
  Interventions:   Behavioral: Progressive Exercise Plan;   Device: NeuromuscularElectricalStimulation(NMES);   Behavioral: Primary Care Management (PCM)
  Sponsors:   University of Tennessee;   Blanchfield Army Community Hospital
  Recruiting
• Plant Exosomes and Patients Diagnosed With Polycystic Ovary Syndrome (PCOS) 17

  NCT03493984

  Condition:   Polycystic Ovary Syndrome
  Interventions:   Other: Ginger exosomes;   Other: Aloe exosomes;   Other: Placebo
  Sponsor:   University of Louisville
  Recruiting
• To Investigate the Gastrointestinal Behaviour of Two Triple Combination Products in Healthy Male Volunteers

  NCT03415243

  Condition:   Common Cold
  Interventions:   Drug: Acetaminophen 650mg+Dextromethorphan 20mg+Phenylephrine 10mg;   Drug: Acetaminophen 325mg+Dextromethorphan 10mg+Phenylephrine 5mg
  Sponsor:   GlaxoSmithKline
  Completed
• Exercise and Weight Control

  NCT03413826

  Conditions:   Obesity;   Exercise Reinforcement
  Intervention:   Behavioral: Exercise
  Sponsor:   University of Kentucky
  Completed
• Influence of n-Acetylcysteine Maintenance on Alcohol Effects

  NCT03216954

  Condition:   Alcohol Use Disorder
  Interventions:   Drug: Alcohol;   Drug: Placebos;   Drug: N-acetyl cysteine
  Sponsors:   William Stoops;   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
  Recruiting
• Dietary Sources of Lysophospholipids

  NCT02952638

  Conditions:   Obesity;   Cardiovascular Risk Factor;   Hyperlipidemia
  Intervention:  
  Sponsor:   University of Kentucky
  Recruiting
• Trial of Self-managed Approaches for Patellofemoral Pain Syndrome in Active Duty

  NCT02597673

  Condition:   Patellofemoral Pain Syndrome
  Interventions:   Other: Home Exercise Program (HEP);   Device: NMES;   Device: TENS
  Sponsors:   University of Tennessee;   Blanchfield Army Community Hospital
  Completed
• Impact of Electronic Cigarettes on Perinatal Immune Responsiveness and Birth Outcomes

  NCT02553577

  Conditions:   Immune Response;   Birth Weight;   Gestational Age
  Intervention:  
  Sponsors:   Kristin Ashford;   Virginia Commonwealth University
  Recruiting
• Reinforcing Effects of Cocaine During Phendimetrazine Maintenance

  NCT02522325

  Condition:   Cocaine Use Disorder
  Interventions:   Drug: Phendimetrazine;   Drug: Cocaine;   Drug: Placebo
  Sponsors:   William Stoops;   National Institute on Drug Abuse (NIDA)
  Completed
• Topiramate-Phentermine Combinations for Cocaine Dependence

  NCT02239913

  Condition:   Cocaine Use Disorder
  Interventions:   Drug: Cocaine;   Drug: Placebo;   Drug: Phentermine;   Drug: Topiramate
  Sponsors:   University of Kentucky;   National Institute on Drug Abuse (NIDA)
  Completed
• Behavioral Effects of Drugs (Inpatient): 40 [Methamphetamine, Methylphenidate, Duloxetine]

  NCT04178993

  Condition:   Methamphetamine Use Disorder
  Interventions:   Drug: Methamphetamine;   Drug: Methylphenidate;   Drug: Placebo oral capsule;   Drug: Duloxetine
  Sponsors:   Craig Rush;   National Institute on Drug Abuse (NIDA)
  Recruiting
• Depression, Trauma, and Health: Efficacy of an mHealth App for Symptom Self-Management in College Students

  NCT04094792

  Condition:   Depression
  Intervention:   Device: Happify Breather App
  Sponsors:   University of Kentucky;   Happify Inc.
  Recruiting
• Personalized Treatment

  NCT04183894

  Conditions:   Eating Disorders;   Eating Disorder Symptom
  Intervention:   Behavioral: Personalized Intervention
  Sponsor:   University of Louisville
  Recruiting
• Kentucky Communities and Researchers Engaging to Halt the Opioid Epidemic (CARE2HOPE)

  NCT04134767

  Conditions:   Substance Use;   HIV Infections;   HCV Infection;   Sexually Transmitted Infections (Not HIV or Hepatitis);   Overdose, Drug;   Opioid Use
  Interventions:   Behavioral: Re-entry Health Linkage;   Behavioral: Overdose Education
  Sponsors:   University of Kentucky;   National Institute on Drug Abuse (NIDA);   Substance Abuse and Mental Health Services Administration (SAMHSA);   Emory University;   Temple University
  Not yet recruiting
• Diagnosis of ON With or Without MS or NMOSD

  NCT04131764

  Conditions:   Multiple Sclerosis;   Neuromyelitis Optica Spectrum Disorder Attack;   Neuromyelitis Optica Spectrum Disorder Relapse;   Neuromyelitis Optica Spectrum Disorder Progression;   Optic Neuritis
  Intervention:   Diagnostic Test: Reflex (Brightlamp Inc., Purdue University)
  Sponsor:   University of Kentucky
  Enrolling by invitation
• MS and NMOSD in African-Americans

  NCT04131673

  Conditions:   Multiple Sclerosis;   Neuromyelitis Optica
  Intervention:  
  Sponsor:   University of Kentucky
  Enrolling by invitation
• Standing, Stepping and Voluntary Movement Spinal Cord Epidural Stimulation

  NCT04123847

  Condition:   Spinal Cord Injuries
  Interventions:   Other: Standing and Stepping;   Device: Standing, Stepping and Voluntary Movement with spinal cord Epidural Stimulation
  Sponsors:   Susan Harkema;   The Leona M. and Harry B. Helmsley Charitable Trust
  Recruiting
• Internet Auditory Rehabilitation: Follow-up to Adult Hearing Screening

  NCT04122183

  Condition:   Hearing Loss
  Intervention:   Other: iManage (my hearing loss)
  Sponsors:   University of Louisville;   William Demant Foundation (Formerly known as the Oticon Foundation)
  Not yet recruiting
• Gastric Electrical Stimulation for Abdominal Pain in Gastroparesis

  NCT04121325

  Condition:   Abdominal Pain
  Intervention:   Device: Enterra
  Sponsor:   University of Louisville
  Not yet recruiting
• Intra-operative Fraction of Inspired Oxygen and Lung Injury in Coronary Artery Bypass Grafting Surgery

  NCT04115501

  Conditions:   Lung Injury;   Pulmonary Complication
  Intervention:   Other: Fraction of Inspired Oxygen
  Sponsors:   University of Louisville;   Peking Union Medical College Hospital;   Tianjin Chest Hospital;   Xiangya Hospital of Central South University;   Guangdong Provincial People's Hospital;   Second Xiangya Hospital of Central South University;   Peking University People's Hospital
  Not yet recruiting
• Transformation of Paralysis to Stepping

  NCT04105114

  Condition:   Spinal Cord Injuries
  Interventions:   Drug: Buspirone;   Device: Non-invasive Spinal Cord Stimulation;   Device: Ekso Bionics Exoskeleton;   Device: Gravity Neutral Device;   Device: Body Weight Supported Treadmill Training;   Device: Rolling Walker
  Sponsor:   University of Louisville
  Not yet recruiting
• Xoft® Intraoperative Radiotherapy (IORT) for Patients With Early-Stage Breast Cancer

  NCT04088435

  Conditions:   Breast Cancer;   Breast Cancer, Invasive Ductal;   Invasive Mammary Carcinoma;   Breast Cancer Stage I;   Breast Cancer Stage IIA
  Intervention:   Radiation: Intraoperative radiotherapy
  Sponsor:   University of Louisville
  Recruiting
• Sodium Watchers Program - Hypertension

  NCT04076280

  Condition:   Hypertension
  Interventions:   Behavioral: Sodium Watcher Program-Hypertension;   Behavioral: Usual Care
  Sponsor:   Misook L. Chung
  Recruiting
• A (Prospective/Pilot) Study Evaluating the Effect of Cataract Surgery on the Daily Activity Levels of Elderly Patients

  NCT04074954

  Conditions:   Cataract;   Diabetes;   Hypertension;   Obesity;   Vision Disability
  Intervention:   Procedure: Cataract surgery
  Sponsor:   University of Pikeville
  Recruiting
• Redefining Survivorship: POWER to Maximize Physical Function for Survivors of Critical Illness

  NCT04058977

  Conditions:   Critical Illness;   Muscle Atrophy or Weakness
  Intervention:   Other: Power training
  Sponsors:   University of Kentucky;   Nathan Johnson, PT, PhD;   Ashley Montgomery-Yates, MD;   Amy Pastva, PT, PhD;   Peter E. Morris, MD
  Not yet recruiting
• Study of Intraoperative Radiotherapy for Patients With Large Brain Metastases Treated With Neurosurgical Resection

  NCT04040400

  Condition:   Brain Metastases
  Intervention:   Device: intraoperative radiotherapy (IORT)
  Sponsor:   University of Louisville
  Recruiting
• A Study to Evaluate the Safety and Effectiveness Assessments of Restylane-Defyne for Punctual Occlusion

  NCT04022382

  Condition:   Dry Eye
  Intervention:   Device: Restylane Defyne
  Sponsor:   John C Meyer, MD
  Completed
• Total Knee Replacement With Tourniquet or Aquamantys

  NCT04016285

  Condition:   Knee Replacement
  Interventions:   Device: Aquamantys;   Device: Tourniquet
  Sponsors:   Stephen Duncan;   Medtronic
  Recruiting
• Hydroxychloroquine to Increase Tumor Suppressor PAR-4 Levels in Oligometastatic Prostate Cancer

  NCT04011410

  Condition:   Prostate Cancer Recurrent
  Intervention:   Drug: Hydroxychloroquine Sulfate 200Mg Tab
  Sponsor:   University of Kentucky
  Not yet recruiting
• Testing a Smart Phone App to Enhance Voice Therapy Adherence

  NCT04002336

  Condition:   Voice Disorders
  Interventions:   Behavioral: Traditional Voice therapy;   Behavioral: Voice Therapy App
  Sponsor:   Vrushali Angadi
  Completed
• Effects of 5HTP and LDOPA on CNS Excitability After SCI

  NCT04000919

  Condition:   Spinal Cord Injuries
  Interventions:   Drug: 5HTP;   Drug: L-DOPA;   Drug: Placebo oral tablet;   Drug: Carbidopa
  Sponsor:   Jessica M D'Amico
  Recruiting
• Non-Invasive Spinal Cord Stimulation After Injury

  NCT03998527

  Condition:   Spinal Cord Injuries
  Intervention:   Device: Transcutaneous Electrical Spinal Cord Stimulation (TcESCS)
  Sponsor:   University of Louisville
  Recruiting
• Study of Lumbar Discectomy With Annular Closure

  NCT03986580

  Condition:   Lumbar Disc Herniation
  Intervention:   Device: BARRICAID device
  Sponsor:   Intrinsic Therapeutics
  Not yet recruiting
• Study of Regional Cerebral Oxygenation and Brain Blood Volume Changes During Carotid Endarterectomy Using the NeurOS System

  NCT03981757

  Condition:   Carotid Disease
  Intervention:   Device: NeurOS
  Sponsor:   University of Louisville
  Recruiting
• Regional Cerebral Oxygenation and Brain Blood Volume During Cardiac Surgery Using the NeurOS System

  NCT03969836

  Condition:   Heart Diseases
  Intervention:   Device: NeurOS system
  Sponsor:   University of Louisville
  Recruiting
• Combination Rucaparib With Nivolumab in Small Cell Lung Carcinoma

  NCT03958045

  Condition:   Small Cell Lung Cancer
  Intervention:   Combination Product: Rucaparib and Nivolumab
  Sponsor:   Aman Chauhan
  Recruiting
• Improving Hand Recovery With Neuromodulation in Tetraplegia

  NCT03954496

  Conditions:   Spinal Cord Injuries;   Tetraplegia, Unspecified, Incomplete, Chronic
  Interventions:   Device: transcranial direct current stimulation;   Behavioral: Intensive upper extremity motor training
  Sponsors:   University of Kentucky;   Wings for Life - spinal cord research foundation
  Recruiting
• Better Together: A Web-based Relationship Education Tool

  NCT03953495

  Condition:   Same-Sex Relationships
  Interventions:   Behavioral: Better Together;   Behavioral: Better Together (delayed)
  Sponsor:   Sharon Scales Rostosky
  Recruiting
• The Kentucky Viral Hepatitis Treatment Study

  NCT03949764

  Conditions:   Hepatitis C;   Opioid-Related Disorders;   Injection Drug Use
  Intervention:   Drug: Sofosbuvir/velpatasvir (Epclusa®)
  Sponsors:   Jennifer Havens;   National Institute on Drug Abuse (NIDA);   National Cancer Institute (NCI);   Gilead Sciences;   University of Kentucky;   Icahn School of Medicine at Mount Sinai;   University of Bristol
  Not yet recruiting
• Tourniquet vs. Short Time Tourniquet in Primary Robotic Assisted TKA

  NCT03942939

  Condition:   Knee Arthropathy
  Interventions:   Other: Primary Robotic-Assisted Total Knee Arthroplasty with a short tourniquet time;   Other: Primary Robotic-Assisted Total Knee Arthroplasty with the use of a tourniquet
  Sponsor:   University of Louisville
  Recruiting
• DUR-928 in Patients With Alcoholic Hepatitis

  NCT03917407

  Condition:   Alcoholic Hepatitis
  Interventions:   Drug: DUR-928 (Moderate AH);   Drug: DUR-928 (Severe AH)
  Sponsors:   Craig James McClain;   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
  Not yet recruiting
• Durvalumab and Tremelimumab Combination in Somatically Hypermutated Recurrent Solid Tumors

  NCT03911557

  Condition:   Tumor, Solid
  Intervention:   Drug: Durvalumab and Tremelimumab
  Sponsor:   John L. Villano, MD, PhD
  Recruiting
• Clinical Trial on the Preventive Effect of Intravaginal Prasterone on Recurrent Urinary Tract Infections in Postmenopausal Women

  NCT03854396

  Conditions:   Recurrent Urinary Tract Infection;   Postmenopause;   Postmenopausal Syndrome;   Postmenopausal Symptoms;   Menopause
  Interventions:   Drug: Prasterone;   Drug: Placebo
  Sponsors:   Olivia Cardenas-Trowers, M.D.;   AMAG Pharmaceuticals, Inc.
  Not yet recruiting
• Intraoral Administration of Botox in Patients With Dentoalveolar Neuropathic Pain

  NCT03848143

  Condition:   Neuropathic Pain
  Intervention:   Drug: onabotulinum toxin A
  Sponsors:   Isabel Moreno Hay;   Allergan Sales, LLC
  Recruiting
• ACB + IPACK Block With or Without Local Infiltration in RA-TKA

  NCT03840122

  Condition:   Knee Arthropathy
  Interventions:   Other: ACB + IPACK block with injection of local anesthetic;   Other: ACB + IPACK block without injection
  Sponsor:   University of Louisville
  Withdrawn
• Dietary Intervention in Persons With Metabolic Syndrome

  NCT03836651

  Condition:   Metabolic Syndrome
  Interventions:   Other: Dietary Antioxidant (V8® Low Sodium 100% vegetable juice);   Other: Control group
  Sponsor:   Martha Biddle
  Recruiting
• Impact of SPEAC® System Data on Therapeutic Decisions Related to Convulsive Seizure Patients With a New Diagnosis

  NCT03742661

  Condition:   Epilepsy
  Intervention:   Device: SPEAC System
  Sponsor:   Brain Sentinel
  Active, not recruiting
• Inflammatory Markers in Trauma Patient Outcomes

  NCT03671746

  Condition:   Polytrauma
  Interventions:   Drug: Ketorolac;   Drug: Saline Solution
  Sponsor:   Arun Aneja
  Recruiting
• Retrospective Analysis on Distal Humerus Fractures

  NCT03637621

  Condition:   Distal Humerus Fracture
  Intervention:   Other: ORIF
  Sponsor:   The Orthopaedic Research & Innovation Foundation
  Active, not recruiting
• Reverse Total Shoulder Arthroplasty: A Data Analysis on Patients Undergoing Reverse Total Shoulder Arthroplasty

  NCT03617107

  Conditions:   Osteo Arthritis Shoulders;   Proximal Humeral Fracture;   Rotator Cuff Tear;   Rotator Cuff Tear Arthropathy
  Intervention:   Other: reverse total shoulder arthroplasty
  Sponsor:   The Orthopaedic Research & Innovation Foundation
  Active, not recruiting
• Does Depth of Neuromuscular Blockade (NMB) Affect Surgical Conditions in Obese Patients Undergoing Robotic Surgery

  NCT03591289

  Conditions:   GYN Disorders;   Urologic Diseases
  Intervention:   Drug: NMB with rocuronium bromide
  Sponsor:   Rainer Lenhardt
  Recruiting
• Community Access, Retention in Care, and Engagement for Hepatitis C Treatment

  NCT03581383

  Condition:   Hepatitis C
  Interventions:   Behavioral: PREP-C;   Behavioral: Modified ECHO
  Sponsor:   Jens Rosenau
  Recruiting
• Building Stronger Allies

  NCT03571750

  Conditions:   Suicide;   Risk Reduction
  Interventions:   Behavioral: Building Stronger Allies;   Behavioral: Health Education Training
  Sponsor:   Florida State University
  Recruiting
• A Review of Low-Dose CT Lung Cancer Screenings in a Community-Based Healthcare System With High Incidence

  NCT03560791

  Condition:   Non-small Cell Lung Cancer
  Intervention:  
  Sponsor:   St Elizabeth Healthcare
  Enrolling by invitation
• Effects of Family Sodium Watcher Program on Outcomes in Heart Failure Patient-Family Caregiver Dyads

  NCT03560206

  Condition:   Heart Failure
  Interventions:   Behavioral: Family SWaP intervention with mini iPad;   Behavioral: usual care
  Sponsor:   Misook L. Chung
  Active, not recruiting
• An Analysis of Treatment Timelines for Lung Cancer Patients Across System Evolutions

  NCT03535766

  Condition:   Lung Cancer
  Intervention:  
  Sponsor:   St Elizabeth Healthcare
  Enrolling by invitation
• Teachable Moment Brief Intervention for Veterans Following a Suicide Attempt

  NCT03533075

  Condition:   Suicide, Attempted
  Intervention:   Behavioral: Teachable Moment Brief Intervention
  Sponsors:   Louisville VA Medical Center;   University of Louisville
  Active, not recruiting
• Idiopathic Parkinson's Progression and Dopamine Transporter SPECT

  NCT03531086

  Condition:   Parkinson Disease
  Intervention:   Drug: Ioflupane I 123
  Sponsor:   Julie Gurwell
  Active, not recruiting
• Tanglewood Trail Walking Program in Rural Kentucky

  NCT03495648

  Condition:   Dietary Habits
  Interventions:   Behavioral: walking group led by a community organizer;   Behavioral: Drive
  Sponsors:   Dawn Brewer;   National Institute of Environmental Health Sciences (NIEHS)
  Active, not recruiting
• BerryCare: A Community Engagement Program

  NCT03477305

  Condition:   Cardiovascular Risk Factor
  Intervention:   Behavioral: Blackberry Consumption
  Sponsors:   Dawn Brewer;   National Institute of Environmental Health Sciences (NIEHS)
  Completed
• Clinic to Community Navigation to Improve Diabetes Outcomes

  NCT03474731

  Condition:   Diabetes Mellitus
  Interventions:   Behavioral: Diabetes Self Management Program;   Behavioral: Tailored Patient Navigation (PN) only;   Behavioral: DSMP AND Tailored Patient Navigation
  Sponsor:   Nancy Schoenberg
  Recruiting
• Social Media HIV Prevention Intervention for High Risk Rural Women

  NCT03456453

  Condition:   HIV/AIDS
  Intervention:   Behavioral: NIDA Standard for HIV Prevention
  Sponsors:   University of Kentucky;   National Institute on Drug Abuse (NIDA)
  Recruiting
• SPARC Bladder Mapping and Training Study

  NCT03452007

  Condition:   Spinal Cord Injuries
  Intervention:   Device: Epidural Stimulation
  Sponsor:   University of Louisville
  Recruiting
• Re-entry XR-NTX for Rural Women With Opioid Use Disorder

  NCT03447743

  Condition:   Opioid Dependence
  Intervention:   Drug: XR-NTX community location
  Sponsor:   University of Kentucky
  Recruiting
• "Assessment of the Quality and Quantity of Bone Regeneration."

  NCT03417375

  Condition:   Bone Quality and Quantity
  Intervention:   Procedure: Bilateral Sinus Augmentation
  Sponsor:   University of Kentucky
  Active, not recruiting
• Chemotherapy-Induced Cognitive Impairment in Ovarian Cancer Patients

  NCT03324945

  Condition:   Chemotherapy-induced Cognitive Impairment
  Intervention:   Behavioral: Neurocognitive assessments
  Sponsors:   University of Kentucky;   Office of US Army Medical Research and Material Command
  Active, not recruiting
• Impact of Envarsus XR® on Kidney Biopsy Subclinical Rejection and Blood Immunologic Profile

  NCT03321656

  Condition:   End Stage Renal Disease
  Interventions:   Drug: Tacrolimus;   Drug: Envarsus XR
  Sponsors:   Roberto Gedaly;   Veloxis Pharmaceuticals
  Recruiting
• Consultation, Advice, and Tailored Support (CATS) for Cancer Survivors

  NCT03316170

  Conditions:   Smoking Cessation;   Social Stress
  Interventions:   Behavioral: Social Support;   Drug: NRT Sampling
  Sponsors:   Jessica Burris;   Kentucky Lung Cancer Research Program
  Recruiting
• Priming Immunotherapy in Advanced Disease With Radiation

  NCT03313804

  Conditions:   Non-small Cell Lung Cancer;   Squamous Cell Carcinoma of the Head and Neck
  Interventions:   Drug: Immune checkpoint inhibitor;   Radiation: Radiation Therapy
  Sponsor:   John L. Villano, MD, PhD
  Recruiting
• Dysregulated CNS Inflammation After Acute Brain Injury

  NCT03287557

  Conditions:   Traumatic Brain Injury;   Aneurysmal Subarachnoid Hemorrhage
  Intervention:  
  Sponsor:   University of Kentucky
  Completed
• A Pilot Study Using Autologous Regulatory T Cell Infusion Zortress (Everolimus) in Renal Transplant Recipients

  NCT03284242

  Conditions:   End Stage Renal Disease;   Kidney Transplant
  Intervention:   Procedure: Apheresis
  Sponsors:   Roberto Gedaly;   Novartis Pharmaceuticals
  Recruiting
• Cocaine Use Reduction and Health

  NCT03224546

  Condition:   Cocaine Use Disorder
  Intervention:   Behavioral: Contingency Management
  Sponsors:   William Stoops;   National Institute on Drug Abuse (NIDA)
  Recruiting
• Intraoperative Amiodarone to Prevent Atrial Fibrillation in Lung Transplant Patients

  NCT03221764

  Conditions:   Atrial Fibrillation;   Lung Transplant; Complications
  Interventions:   Drug: Amiodarone with CoSeal;   Device: CO2 driver
  Sponsor:   University of Louisville
  Completed
• Blood And Clot Thrombectomy Registry And Collaboration

  NCT03153683

  Condition:   Acute Ischemic Stroke
  Intervention:   Other: Registry
  Sponsors:   Justin Fraser;   University of Kentucky
  Recruiting
• Vitamin D for Muscle Metabolic Function in Cancer Cachexia

  NCT03144128

  Conditions:   Cancer Cachexia;   Vitamin D Deficiency
  Interventions:   Dietary Supplement: Vitamin D;   Dietary Supplement: Placebo
  Sponsor:   David Travis Thomas
  Recruiting
• Apolipoprotein E (ApoE) and Metabolism

  NCT03109561

  Conditions:   Cognitive Function;   Healthy
  Interventions:   Other: Resting State Indirect Calorimetry;   Genetic: ApoE;   Diagnostic Test: Metabolism;   Other: Cognitive Challenge
  Sponsor:   Lance Johnson
  Recruiting
• Evaluating Genomic Testing in Human Cancer & Outcomes of Targeted Therapies

  NCT03089554

  Condition:   Cancer
  Intervention:   Drug: Therapeutic Intervention
  Sponsor:   Rachel Miller
  Recruiting
• Video-Laryngoscope Alone or With Bronchoscope for Predicted Difficult Intubation

  NCT03080896

  Condition:   Intubation; Difficult
  Interventions:   Device: King Vision video-laryngoscope with #3 disposable blade and endotracheal tube stylet;   Device: fiberoptic bronchoscope aScope III
  Sponsors:   University of Louisville;   Ambu A/S
  Recruiting
• Rural Intervention for Caregivers' Heart Health

  NCT03068390

  Condition:   Cardiovascular Risk Factor
  Interventions:   Behavioral: RICHH Intervention;   Behavioral: Usual care
  Sponsors:   Debra Moser;   National Institute of Nursing Research (NINR)
  Recruiting
• Recovery of Bladder and Sexual Function After Spinal Cord Injury

  NCT03036527

  Condition:   Spinal Cord Injuries
  Interventions:   Procedure: Activity-based locomotor training;   Procedure: Activity-based stand training;   Procedure: Activity-based upper arm ergometry
  Sponsor:   University of Louisville
  Recruiting
• Biological Effects of Agent on PAR-4 Levels With Resected Solid Tumors

  NCT03015324

  Condition:   Solid Tumor
  Intervention:   Drug: Hydroxychloroquine
  Sponsor:   Peng Wang, MD PhD
  Recruiting
• Fosbretabulin With Everolimus in Neuroendocrine Tumors With Progression

  NCT03014297

  Conditions:   Neuroendocrine Tumors;   Everolimus
  Interventions:   Drug: everolimus;   Drug: fosbretabulin
  Sponsor:   Lowell Anthony, MD
  Terminated
• Impact of an Intensive Monitoring Strategy in Symptomatic Patients With Suspected Arrhythmia

  NCT03001765

  Condition:   Suspected Arrhythmia
  Intervention:   Other: Intensive Monitoring Strategy: Reveal LINQ™ Insertable Cardiac Monitoring System".
  Sponsor:   St Elizabeth Healthcare
  Completed
• Cisplatin + Radiation in SCCHN and Correlation With Oxidative Stress Markers

  NCT02994069

  Conditions:   Carcinoma, Squamous Cell;   Head and Neck Cancer
  Interventions:   Drug: Cisplatin;   Radiation: XRT
  Sponsor:   Susanne Arnold
  Recruiting
• Electronic Decision Support for Intervention in Poorly Controlled Type 2 Diabetes

  NCT02924207

  Condition:   Diabetes Mellitus
  Intervention:   Other: PATH electronic decision support tool
  Sponsors:   St Elizabeth Healthcare;   PATH Decision Support Software, LLC
  Completed
• Low Sodium vs. Regular Diet in Patients Admitted for Heart Failure

  NCT02689635

  Condition:   Heart Failure
  Interventions:   Other: Sodium Restricted Diet;   Other: Regular Diet
  Sponsor:   Maya Guglin
  Recruiting
• Percutaneous Nerve Evaluation With Fluoroscopy Versus Without

  NCT02677753

  Conditions:   Overactive Bladder;   Urinary Incontinence;   Fecal Incontinence
  Intervention:   Radiation: Fluoroscopy
  Sponsor:   University of Louisville
  Completed
• Achieving Patient-Centered Care and Optimized Health In Care Transitions by Evaluating the Value of Evidence

  NCT02354482

  Condition:   Care Transitions
  Interventions:   Behavioral: Patient Communication and Care Management;   Behavioral: Home-Based Trust, Plain Language, and Coordination;   Behavioral: Hospital-Based Trust, Plain Language, and Coordination;   Behavioral: Patient/Caregiver Assessment and Provider Information Exchange;   Behavioral: Assessment and Teach Back;   Other: Standard of Care (Reference)
  Sponsors:   Mark Williams;   University of Pennsylvania;   Boston Medical Center;   Westat;   Kaiser Permanente;   Telligen, Inc.;   University of Illinois at Chicago;   Hospital Research & Education Trust, American Hospital Association;   Joint Commission Resources;   America's Essential Hospitals;   Louisiana State University Health Sciences Center Shreveport;   United Hospital Fund;   Caregiver Action Network;   National Association of Area Agencies on Aging
  Completed
• Epi Stim to Facilitate Standing and Stepping

  NCT02339233

  Condition:   Spinal Cord Injury
  Intervention:   Device: Standing and Stepping with spinal cord Epidural Stimulation
  Sponsors:   University of Louisville;   University of California, Los Angeles;   Christopher Reeve Paralysis Foundation;   Kessler Foundation;   The Leona M. and Harry B. Helmsley Charitable Trust;   National Institute for Biomedical Imaging and Bioengineering (NIBIB)
  Completed
• Effect of All-Stim 2 Quadriceps Treatments on Limb Muscle Strength In Mechanically Ventilated Patients

  NCT02332187

  Condition:   Weakness
  Interventions:   Device: Active electrical stimulation using an All Stim stimulator;   Device: Sham electrical stimulation using an All Stim stimulator
  Sponsor:   Gerald Supinski
  Recruiting
• Sildenafil in Heart Failure With Reactive Pulmonary Hypertension

  NCT02304705

  Condition:   Heart Failure With Reactive Pulmonary Hypertension
  Interventions:   Drug: Sildenafil;   Drug: Placebo
  Sponsor:   Maya Guglin
  Terminated
• Transcutaneous Spinal Stimulation: Safety and Feasibility for Upper Limb Function in Children With Spinal Cord Injury

  NCT04032990

  Condition:   Spinal Cord Injuries
  Intervention:   Device: Biostim-5 transcutaneous spinal stimulator
  Sponsors:   University of Louisville;   The Jewish Heritage Foundation for Excellence
  Not yet recruiting
• HCQ on PAR-4 Levels in Patients With Resectable Solid Tumors

  NCT02232243

  Condition:   Solid Tumor
  Interventions:   Drug: Hydroxychloroquine, 200mg twice dailiy;   Drug: Hydroxychloroquine, 400mg twice daily
  Sponsor:   Peng Wang, MD PhD
  Completed
• A Study of Chemo +/- Low-dose Radiation as Induction Therapy in SCCHN

  NCT02126969

  Conditions:   Head and Neck Cancer;   Larynx
  Interventions:   Radiation: Low dose fractionated radiation - 80cGy with chemotherapy;   Drug: Docetaxel and Carboplatin AUC 6
  Sponsor:   University of Kentucky
  Active, not recruiting
• Blood Lipopolysaccharide (LPS) Rifaximin Study

  NCT02124512

  Conditions:   Obese;   Insulin Resistance;   Metabolic Syndrome
  Interventions:   Drug: Rifaximin SSD;   Other: Placebo
  Sponsors:   Philip Kern;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
  Completed
• Randomized Study of Beet Root in Locally Advanced Squamous Cell Cancer of the Head and Neck

  NCT02058849

  Condition:   Mucositis
  Interventions:   Drug: Beetroot;   Other: Placebo
  Sponsor:   David Travis Thomas
  Completed
• Cohort 2 Efficacy of Nasopharyngeal Ventilation With Endotracheal Tube for Surgery

  NCT02018146

  Condition:   General Anesthesia With Endotracheal Intubation in Surgery
  Interventions:   Other: Mask then nasopharyngeal;   Other: Nasopharyngeal then mask
  Sponsor:   University of Louisville
  Completed
• Early Detection and Prevention of Mild Cognitive Impairment Due to Cerebrovascular Disease

  NCT01924312

  Conditions:   Cerebrovascular Disease;   Mild Cognitive Impairment
  Intervention:   Behavioral: Heart Health Intervention
  Sponsor:   Gregory Jicha, 323-5550
  Completed
• Safety of Pentoxifylline and Vitamin E With Stereotactic Ablative Radiotherapy (SABR) in Non-small Cell Lung Cancers

  NCT01871454

  Condition:   Non-small Cell Lung Cancers
  Interventions:   Radiation: stereotactic ablative radiotherapy (SABR);   Drug: Pentoxifylline
  Sponsors:   University of Louisville;   James Graham Brown Cancer Center
  Recruiting
• Early Anti-inflammatory Treatment in Patients With Acute ACL Tear and Painful Effusions

  NCT03429140

  Condition:   Anterior Cruciate Ligament
  Interventions:   Drug: Gel-One;   Other: Saline Placebo
  Sponsor:   Mary Ireland
  Active, not recruiting
• Brief Intervention for Rural Women at High Risk for HIV/HCV

  NCT01840722

  Conditions:   Acquired Immune Deficiency Syndrome Virus;   Hepatitis C;   Drug Abuse
  Intervention:   Other: MI-based HIV Risk Reduction
  Sponsors:   Michele Staton;   National Institute on Drug Abuse (NIDA)
  Completed
• Overcoming Chemotherapy Resistance In Refractory Multiple Myeloma With Simvastatin and Zoledronic Acid

  NCT01772719

  Condition:   Multiple Myeloma
  Intervention:   Drug: Simvastatin and zoledronic acid
  Sponsors:   University of Louisville;   James Graham Brown Cancer Center
  Terminated
• Study of Lung Cancer in Appalachian Kentucky: The Role of Environmental Carcinogens

  NCT01648166

  Condition:   Lung Cancer
  Intervention:   Other: Environmental sampling
  Sponsors:   Susanne Arnold;   United States Department of Defense
  Completed
• IL-1RA Treatment in Patients With Acute ACL Tear and Painful Effusions

  NCT02930122

  Condition:   Anterior Cruciate Ligament Tear
  Interventions:   Drug: Saline (0.9%) and anakinra (150mg);   Drug: anakinra (150mg) and Saline (0.9%);   Other: Saline intraarticularly
  Sponsors:   Cale Jacobs, PhD;   Arthritis Foundation
  Recruiting
• A Feasibility Study Using Four-Dimensional CT Imaging for Primary Lung Cancer

  NCT01500876

  Condition:   Lung Cancer
  Intervention:   Radiation: 4D-CT pre-treatment scan
  Sponsors:   University of Louisville;   James Graham Brown Cancer Center
  Active, not recruiting
• Accelerated Hypofractionated Radiotherapy (AHF-RT) for the Treatment of Breast Cancer

  NCT01278212

  Condition:   Breast Cancer
  Intervention:   Radiation: accelerated hypofractionated radiotherapy (AHF-RT)
  Sponsors:   University of Louisville;   James Graham Brown Cancer Center
  Active, not recruiting
• The Effect of Beta-glucan in Non-Small Cell Lung Cancer

  NCT00682032

  Condition:   Non Small Cell Lung Cancer
  Intervention:   Dietary Supplement: beta-glucan
  Sponsors:   University of Louisville;   James Graham Brown Cancer Center
  Recruiting
• Fondaparinux for the Treatment of Heparin-Induced Thrombocytopenia (HIT)

  NCT00673439

  Condition:   Heparin-Induced Thrombocytopenia
  Interventions:   Drug: fondaparinux;   Drug: warfarin
  Sponsors:   University of Louisville;   James Graham Brown Cancer Center
  Terminated
• Study of Taxotere and Doxil to Treat Advanced Androgen-Independent Prostate Cancer

  NCT00456989

  Condition:   Prostate Cancer
  Interventions:   Drug: Taxotere;   Drug: Doxil
  Sponsors:   University of Louisville;   James Graham Brown Cancer Center
  Completed
• Prognostic Markers of Gynecologic Cancers

  NCT00290459

  Conditions:   Gynecologic Disease;   Gynecologic Cancer
  Intervention:  
  Sponsors:   University of Louisville;   James Graham Brown Cancer Center
  Recruiting
• Effects of Folfirinox and Stereotactic Body Radiation Therapy for Advanced Pancreatic Cancer

  NCT02128100

  Condition:   Pancreatic Cancer Non-resectable
  Interventions:   Drug: Folfirinox;   Radiation: Stereotactic Body Radiation Therapy
  Sponsors:   University of Louisville;   James Graham Brown Cancer Center
  Recruiting
• Epicutaneous Cryoimmunotherapy Combined With Pembrolizumab for Cutaneous Metastatic Breast Cancer

  NCT03982004

  Condition:   Metastatic Breast Cancer
  Interventions:   Device: Epicutaneous cryoimmunotherapy;   Drug: Topical imiquimod;   Drug: Pembrolizumab;   Other: Dermatologic Quality of Life Index;   Other: Functional Assessment of Cancer Therapy;   Drug: Intra-lesional GM-CSF;   Device: Cry-AC
  Sponsors:   Washington University School of Medicine;   Merck Sharp & Dohme Corp.
  Not yet recruiting
• Comparative Effectiveness of IIMR to the CDSMP

  NCT03966872

  Conditions:   Mental Illness;   Chronic Disease
  Interventions:   Behavioral: Integrated Illness Management and Recovery;   Behavioral: Chronic Disease Self-Management Program
  Sponsors:   Dartmouth-Hitchcock Medical Center;   Patient-Centered Outcomes Research Institute
  Recruiting
• Glutaminase Inhibitor CB-839 Hydrochloride and Osimertinib in Treating Patients With EGFR-Mutated Stage IV Non-small Cell Lung Cancer

  NCT03831932

  Conditions:   Advanced Lung Non-Small Cell Carcinoma;   Metastatic Lung Non-Small Cell Carcinoma;   Stage IV Lung Cancer AJCC v8;   Stage IVA Lung Cancer AJCC v8;   Stage IVB Lung Cancer AJCC v8
  Interventions:   Drug: Glutaminase Inhibitor CB-839;   Drug: Glutaminase Inhibitor CB-839 Hydrochloride;   Drug: Osimertinib
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Post-Market Study of Comprehensive Reverse Augmented Glenoid and Mini Humeral Tray in Total Shoulder Arthroplasty

  NCT03726554

  Conditions:   Arthropathy of Shoulder Region;   Grossly Deficient Rotator Cuff;   Osteoarthritis of the Shoulder;   Rheumatoid Arthritis Without Humeral Metaphyseal Defects;   Post-Traumatic Arthritis
  Interventions:   Device: Comprehensive Reverse Porous Augmented Glenoid;   Device: Comprehensive Mini Humeral Tray
  Sponsor:   Zimmer Biomet
  Recruiting
• Clinical Trial to Evaluate the Efficacy of OC-02 Nasal Spray on Signs and Symptoms of Dry Eye Disease (The RAINIER Study)

  NCT03633461

  Condition:   Dry Eye Disease
  Interventions:   Drug: OC-02;   Drug: Placebo
  Sponsor:   Oyster Point Pharma, Inc.
  Completed
• A Trial for Treatment of Cancer Patients With Multiple Brain Metastases Undergoing Whole-Brain Radiotherapy

  NCT03608020

  Condition:   Multiple Brain Metastases
  Interventions:   Drug: BMX-001;   Radiation: Whole Brain Radiation Therapy
  Sponsors:   BioMimetix JV, LLC;   Duke Cancer Institute;   National Cancer Institute (NCI)
  Recruiting
• Breast Cancer Recurrence Risk Counseling

  NCT03339518

  Condition:   Breast Cancer Female
  Interventions:   Behavioral: BRIM3 educational intervention;   Behavioral: Wait List
  Sponsors:   West Virginia University;   University of Kentucky
  Completed
• Randomized Controlled Trial for Exparel Hip Fracture

  NCT03289858

  Condition:   Hip Fractures
  Interventions:   Drug: Exparel;   Drug: Sodium Chloride
  Sponsors:   University of Massachusetts, Worcester;   Orthopaedic Trauma Association;   University of Kentucky
  Completed
• The Appeal and Impact of E-cigarettes in Smokers With SMI

  NCT03050853

  Conditions:   Tobacco Dependence;   Schizophrenia;   Bipolar Disorder;   Schizoaffective Disorder
  Intervention:   Behavioral: E-cigarette
  Sponsors:   Dartmouth-Hitchcock Medical Center;   Vinfen Corporation;   Centerstone Kentucky
  Recruiting
• A Study Investigating the Safety, Tolerability, and Efficacy of Elamipretide Topical Ophthalmic Solution for the Treatment of Fuchs' Corneal Endothelial Dystrophy (FCED)

  NCT02653391

  Condition:   Fuchs' Corneal Endothelial Dystrophy (FCED)
  Interventions:   Drug: Elamipretide 1.0% Ophthalmic Solution;   Drug: Elamipretide 3.0% Ophthalmic Solution
  Sponsor:   Stealth BioTherapeutics Inc.
  Completed
• A Safety and Efficacy Study of Tavilermide (MIM-D3) Ophthalmic Solution for the Treatment of Dry Eye

  NCT02634853

  Condition:   Keratoconjunctivitis Sicca
  Interventions:   Drug: 1% Tavilermide Ophthalmic Solution;   Drug: Placebo Ophthalmic Solution
  Sponsor:   Mimetogen Pharmaceuticals USA, Inc.
  Completed
• Evaluation of the Technical Success of IVUS Guided VCF Placement Using the LUMIFI™ With Crux® VCF System

  NCT02394912

  Conditions:   Pulmonary Embolism;   Deep Vein Thrombosis
  Intervention:   Device: vena cava filter implantation (LUMIFI with Crux VCF System)
  Sponsor:   Volcano Corporation
  Terminated
• An Evaluation of Two PTSD Assessments in an Active Duty and Military Veteran Sample

  NCT04180930

  Condition:   Stress Disorders, Post-Traumatic
  Interventions:   Diagnostic Test: CAPS-5;   Diagnostic Test: PSSI-5;   Diagnostic Test: CAPS-IV
  Sponsor:   U.S. Army Medical Research and Development Command
  Recruiting
• Characterize the Nicotine Uptake and Subjective Effects With Use of JUUL Electronic Nicotine Delivery Systems

  NCT04123041

  Conditions:   Electronic Cigarette Use;   Tobacco Smoking
  Intervention:   Other: JUUL ENDS, Combustible cigarette, comparator e-cigarette, Nicorette gum
  Sponsor:   Juul Labs, Inc.
  Enrolling by invitation
• A Pivotal Study of Safety and Effectiveness of NanoKnife IRE for Stage 3 Pancreatic Cancer

  NCT03899636

  Condition:   Stage III Pancreatic Cancer
  Interventions:   Drug: Modified FOLFIRINOX Regimen;   Device: NanoKnife System
  Sponsor:   Angiodynamics, Inc.
  Recruiting
• Performance of MOTO Medial® Unicompartmental Knee Arthroplasty

  NCT03211663

  Conditions:   Knee Osteoarthritis;   Knee Arthritis;   Knee Pain Chronic
  Intervention:   Device: MOTO Medial® UKA
  Sponsor:   Medacta USA
  Recruiting
• Induction of Donor Specific Tolerance in Recipients of Live Donor Kidney Allografts by Donor Stem Cell Infusion

  NCT00498160

  Condition:   Renal Failure
  Intervention:   Biological: Enriched Hematopoetic Stem Cell Infusion
  Sponsors:   University of Louisville;   Northwestern University
  Active, not recruiting
• The Prevalence of White Spot Lesions During Orthodontic Treatment With Fixed Appliances

  NCT04186065

  Condition:   Dental Caries
  Intervention:  
  Sponsor:   Hiroko Nagaoka
  Enrolling by invitation
• Conquering Feared Foods Study

  NCT04155788

  Conditions:   Eating Disorder Symptom;   Fear
  Intervention:   Behavioral: Food Exposure
  Sponsor:   University of Louisville
  Recruiting
• Adrenergic Cholinergic Enteric Measures/Mapping

  NCT04013282

  Condition:   Obesity
  Intervention:  
  Sponsor:   University of Louisville
  Recruiting
• Elbow Arthroscopy Data Analysis

  NCT03656185

  Conditions:   Osteoarthritis Elbow Left;   Osteoarthritis Elbow Right;   Lateral Epicondylitis, Left Elbow;   Lateral Epicondylitis, Right Elbow;   Plica Syndromes;   Osteochondritis Dissecans
  Intervention:  
  Sponsor:   The Orthopaedic Research & Innovation Foundation
  Active, not recruiting
• Telemedicine-based, Multidisciplinary-team, Intervention to Reduce Unnecessary Hospitalizations

  NCT03378245

  Conditions:   Dementia Alzheimers;   Disruptive Behavior
  Intervention:   Behavioral: Behavioral modification and education on pharmacologic treatments.
  Sponsor:   Richard Ronan Murphy
  Suspended
• A Multiple Dose Opioid Challenge Study

  NCT02611752

  Condition:   Moderate or Severe Opioid Use Disorder
  Intervention:   Drug: CAM2038
  Sponsor:   Braeburn Pharmaceuticals
  Completed
• Communities Helping the Hearing of Infants by Reaching Parents

  NCT03875339

  Condition:   Congenital Hearing Loss
  Intervention:   Behavioral: Navigator Guidance
  Sponsors:   University of Kentucky;   National Institute on Deafness and Other Communication Disorders (NIDCD);   National Institutes of Health (NIH)
  Active, not recruiting
• A Clinical Study to Evaluate the Clinical Performance and Safety of LiquiBand FIX8® Versus AbsorbaTack™ for Hernia Mesh Fixation and Peritoneal Closure in Groin Hernia Repair

  NCT04009213

  Conditions:   Hernia;   Inguinal Hernia;   Femoral Hernia;   Groin Hernia
  Interventions:   Device: LiquiBand FIX8®;   Device: AbsorbaTack™
  Sponsor:   Advanced Medical Solutions Ltd.
  Recruiting
• Birinapant and Intensity Modulated Re-Irradiation Therapy in Treating Patients With Locally Recurrent Head and Neck Squamous Cell Carcinoma

  NCT03803774

  Condition:   Recurrent Head and Neck Squamous Cell Carcinoma
  Interventions:   Drug: Birinapant;   Radiation: Intensity-Modulated Radiation Therapy
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Inhaled Treprostinil in Patients With Pulmonary Hypertension Due to Chronic Obstructive Pulmonary Disease (PH-COPD)

  NCT03794583

  Conditions:   Pulmonary Hypertension;   Chronic Obstructive Pulmonary Disease
  Intervention:   Drug: Inhaled treprostinil solution
  Sponsors:   United Therapeutics;   Lung Biotechnology PBC
  Enrolling by invitation
• Harnessing Neuroplasticity to Enhance Functional Recovery During Chronic Recovery From Upper Extremity Nerve Repair

  NCT03610763

  Conditions:   Hand Transplantation;   Peripheral Nerve Injuries;   Neurologic Rehabilitation
  Interventions:   Device: Transcranial Direct Current Stimulation;   Behavioral: Modified Constraint Induced Movement Therapy
  Sponsors:   University of Missouri-Columbia;   Washington University School of Medicine;   Christine M. Kleinert Institute for Hand and Microsurgery
  Recruiting
• Safety/Efficacy of Nepafenac Punctal Plug Delivery System Compared to Placebo to Control Ocular Pain/Inflammation After Cataract

  NCT03496467

  Conditions:   Pain;   Inflammation
  Interventions:   Combination Product: Nepafenac PPDS;   Combination Product: Placebo PPDS
  Sponsor:   Mati Therapeutics Inc.
  Completed
• An Open-Label Study to Enable Continued Treatment Access for Subjects Previously Enrolled in Studies of Ruxolitinib

  NCT02955940

  Conditions:   Pancreatic Cancer;   Colorectal Cancer (CRC);   Breast Cancer;   Lung Cancer
  Interventions:   Drug: Ruxolitinib;   Drug: Capecitabine;   Drug: Regorafenib
  Sponsor:   Incyte Corporation
  Enrolling by invitation
• Collection of Serum Samples From Children and Older Adults Receiving the 2019-2020 Formulations of Fluzone® Quadrivalent and Fluzone® High-Dose Influenza Vaccines, Respectively

  NCT04109222

  Condition:   Influenza
  Interventions:   Biological: Fluzone Quadrivalent vaccine, 2019-2020 formulation;   Biological: Fluzone High-Dose vaccine, 2019-2020 formulation
  Sponsor:   Sanofi Pasteur, a Sanofi Company
  Recruiting
• Journey of Hope in Appalachia: Supporting Resilience in the Region's Youth

  NCT04096937

  Condition:   Adverse Childhood Experiences
  Intervention:   Other: Focus groups
  Sponsors:   Gia Mudd;   West Virginia University
  Not yet recruiting
• Phase I Trial HIPEC With Nal-irinotecan

  NCT04088786

  Conditions:   Peritoneal Cancer;   Pseudomyxoma Peritonei;   Mucinous Adenocarcinoma;   Mucinous Tumor;   Colorectal Cancer;   Gastric Cancer;   Primary Peritoneal Carcinoma;   Mesothelioma
  Intervention:   Drug: nanoliposomal irinotecan
  Sponsors:   Stony Brook University;   University of Kentucky;   University of San Diego
  Recruiting
• Copanlisib Hydrochloride and Nivolumab in Treating Patients With Recurrent or Refractory Diffuse Large B-cell Lymphoma or Primary Mediastinal Large B-cell Lymphoma

  NCT03484819

  Conditions:   Recurrent Diffuse Large B-Cell Lymphoma;   Recurrent Primary Mediastinal (Thymic) Large B-Cell Cell Lymphoma;   Refractory Diffuse Large B-Cell Lymphoma;   Refractory Primary Mediastinal (Thymic) Large B-Cell Cell Lymphoma
  Interventions:   Drug: Copanlisib;   Drug: Copanlisib Hydrochloride;   Biological: Nivolumab
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Pharmacokinetic Single Dose Study of Oral Lasmiditan in Participants With Normal and Impaired Hepatic Function

  NCT03040479

  Condition:   Migraine
  Intervention:   Drug: lasmiditan 200 mg
  Sponsors:   Eli Lilly and Company;   Algorithme Pharma Inc;   CoLucid Pharmaceuticals
  Completed
• Implementation of Prolonged Exposure in the Military

  NCT02982538

  Condition:   PTSD
  Interventions:   Behavioral: Extended Training in Prolonged Exposure Therapy for PTSD;   Behavioral: Standard Training in Prolonged Exposure Therapy for PTSD
  Sponsors:   University of Pennsylvania;   University of Texas
  Active, not recruiting
• A Registry Study of NanoKnife IRE for Stage 3 Pancreatic Cancer

  NCT03899649

  Condition:   Stage III Pancreatic Cancer
  Interventions:   Drug: SOC;   Device: NanoKnife System
  Sponsor:   Angiodynamics, Inc.
  Recruiting
• Bio2 Vitrium® Cervical Cage in Anterior Cervical Discectomy and Fusion

  NCT03828136

  Condition:   Symptomatic Cervical Disc Disease
  Interventions:   Device: Bio2 Vitrium® Cervical Interbody Device;   Device: Allograft Ring or Block
  Sponsors:   Bio2 Technologies;   Musculoskeletal Clinical Regulatory Advisers
  Recruiting
• Continued Access to PREVAIL (CAP2) - WATCHMAN Left Atrial Appendage (LAA) Closure Technology

  NCT01760291

  Condition:   Atrial Fibrillation
  Intervention:   Device: WATCHMAN LAA Closure Technology
  Sponsor:   Boston Scientific Corporation
  Completed
• Phase I/II Pilot Study of Mixed Chimerism to Treat Hemoglobinopathies

  NCT01419704

  Conditions:   Anemia, Sickle Cell;   Complex and Transfusion-dependent Hemoglobinopathies;   Thalassemia;   Diamond-Blackfan Anemia;   Bone Marrow Failure Syndromes;   Alpha-Thalassemia;   Beta-Thalassemia
  Intervention:   Biological: Enriched Hematopoetic Stem Cell Infusion
  Sponsors:   University of Louisville;   Duke University
  Suspended
• Telepharmacy Robotic Medicine Delivery Unit "TRMDU" Assessment

  NCT01007006

  Conditions:   Traumatic Brain Injury;   Posttraumatic Stress Disorders;   Trauma;   Combat Disorders;   Pain
  Intervention:   Device: TMRDU
  Sponsors:   University of Illinois at Chicago;   U.S. Army Medical Research and Development Command
  Withdrawn
• Safety and Efficacy of Ophthalmic Phentolamine Mesylate to Reverse Pharmacologically Induced Mydriasis

  NCT04024891

  Conditions:   Mydriasis;   Dilation
  Interventions:   Drug: Phentolamine Mesylate Ophthalmic Solution 1%;   Other: Phentolamine Mesylate Ophthalmic Solution Vehicle (Placebo)
  Sponsor:   Ocuphire Pharma, Inc.
  Completed
• A Phase 1/2, Randomized, Placebo-controlled, Observer-blinded Trial To Evaluate The Safety, Tolerability, And Immunogenicity Of A Multivalent Group B Streptococcus Vaccine In Healthy Adults 18 To 49 Years Of Age

  NCT03170609

  Condition:   Group B Streptococcal Infections
  Interventions:   Biological: Multivalent group B streptococcus vaccine;   Biological: Placebo
  Sponsor:   Pfizer
  Completed
• Safety and Immunogenicity of the Bris10 M2SR and Sing2016 M2SR H3N2 Monovalent Influenza Vaccines

  NCT03999554

  Condition:   Influenza A
  Interventions:   Biological: LD Sing2016 M2SR H3N2 influenza vaccine;   Biological: MD Sing2016 M2SR H3N2 influenza vaccine;   Biological: HD Sing2016 M2SR H3N2 influenza vaccine;   Biological: LD Bris10 M2SR H3N2 influenza vaccine;   Other: Placebo
  Sponsor:   FluGen Inc
  Recruiting
• Panblok H7 Vaccine Adjuvanted With AS03 or MF59

  NCT03283319

  Condition:   Influenza, Human
  Interventions:   Biological: 3.75 ug Panblok H7;   Biological: 7.5 ug Panblok H7;   Biological: 15 ug Panblok H7;   Biological: MF59;   Biological: AS03
  Sponsors:   Biomedical Advanced Research and Development Authority;   Rho, Inc.
  Completed
• Safety and Immunogenicity of Fluzone® Quadrivalent, Flublok® Quadrivalent, and Fluzone® High-Dose, Influenza Vaccines, 2018-2019 Formulations

  NCT03617523

  Condition:   Influenza
  Interventions:   Biological: Fluzone Quadrivalent vaccine, 2018-2019 formulation;   Biological: Flublok Quadrivalent vaccine, 2018-2019 formulation;   Biological: Fluzone High-Dose vaccine, 2018-2019 formulation
  Sponsor:   Sanofi Pasteur, a Sanofi Company
  Completed
• A Study Evaluating the Safety and Efficacy of OTX-DP for the Treatment of Allergic Conjunctivitis

  NCT04050865

  Condition:   Allergic Conjunctivitis
  Interventions:   Drug: Dexamethasone, 0.4mg;   Device: Placebo plug with no drug
  Sponsor:   Ocular Therapeutix, Inc.
  Recruiting
• A Study of Nivolumab +/- Nab-paclitaxel in Non-small Cell Lung Cancer

  NCT02967133

  Conditions:   Non-Small-Cell Lung Cancer Metastatic;   Non-Small Cell Carcinoma of Lung, TNM Stage 4;   Nonsmall Cell Lung Cancer;   Non Small Cell Lung Cancer Recurrent
  Interventions:   Drug: Nivolumab;   Drug: nab-paclitaxel
  Sponsors:   Alliance Foundation Trials, LLC.;   Celgene Corporation;   Bristol-Myers Squibb
  Active, not recruiting
• Phase 1 Study of BXQ-350 in Adult Patients With Advanced Solid Tumors

  NCT02859857

  Condition:   Neoplasms
  Intervention:   Drug: BXQ-350
  Sponsors:   Bexion Pharmaceuticals, Inc.;   CTI Clinical Trial and Consulting Services
  Active, not recruiting
• Onalespib and Paclitaxel in Treating Patients With Advanced Triple Negative Breast Cancer

  NCT02474173

  Conditions:   Advanced Breast Carcinoma;   Metastatic Breast Carcinoma;   Stage III Breast Cancer AJCC v7;   Stage IIIA Breast Cancer AJCC v7;   Stage IIIB Breast Cancer AJCC v7;   Stage IIIC Breast Cancer AJCC v7;   Stage IV Breast Cancer AJCC v6 and v7;   Triple-Negative Breast Carcinoma
  Interventions:   Other: Laboratory Biomarker Analysis;   Drug: Onalespib;   Drug: Onalespib Lactate;   Drug: Paclitaxel;   Other: Pharmacological Study
  Sponsor:   National Cancer Institute (NCI)
  Active, not recruiting
• Testing the Combination of Cabozantinib, Nivolumab, and Ipilimumab (CaboNivoIpi) for Advanced Differentiated Thyroid Cancer

  NCT03914300

  Conditions:   Differentiated Thyroid Gland Carcinoma;   Follicular Variant Thyroid Gland Papillary Carcinoma;   Poorly Differentiated Thyroid Gland Carcinoma;   Progressive Thyroid Carcinoma;   Refractory Thyroid Gland Carcinoma;   Tall Cell Variant Thyroid Gland Papillary Carcinoma;   Thyroid Gland Follicular Carcinoma;   Thyroid Gland Hurthle Cell Carcinoma;   Thyroid Gland Papillary Carcinoma
  Interventions:   Drug: Cabozantinib;   Drug: Cabozantinib S-malate;   Biological: Ipilimumab;   Biological: Nivolumab
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Pre-Operative Cemiplimab Administered Intralesionally for Patients With Recurrent Cutaneous Squamous Cell Carcinoma

  NCT03889912

  Condition:   Cutaneous Squamous Cell Carcinoma
  Intervention:   Drug: Cemiplimab
  Sponsors:   Regeneron Pharmaceuticals;   Sanofi
  Recruiting
• Phase I/II Pilot Study of Mixed Chimerism to Treat Hemoglobinopathies

  NCT00777231

  Condition:   Sickle Cell Disease
  Intervention:   Biological: Enriched Hematopoetic Stem Cell Infusion
  Sponsors:   University of Louisville;   Duke University;   St. Christopher's Hospital for Children;   The Western Pennsylvania Hospital;   University of Florida;   Medical College of Pennsylvania Hospital;   Hahnemann University Hospital
  Completed
• Bempedoic Acid + Ezetimibe Fixed-Dose Combination (FDC) Study in Patients With Type 2 Diabetes and Elevated LDL-C

  NCT03531905

  Conditions:   Diabetes;   Diabetes Mellitus, Type 2;   Cholesterolemia
  Interventions:   Drug: Bempedoic acid + Ezetimibe FDC Oral Tablet;   Drug: Ezetimibe 10Mg Oral Tablet;   Drug: Placebo Oral Tablet;   Drug: Placebo oral capsule
  Sponsor:   Esperion Therapeutics
  Completed
• Lumbar Discectomy Control Study, Risk Factors for Reherniation

  NCT02477176

  Condition:   Lumbar Spine Disc Herniation
  Intervention:   Other: Discectomy
  Sponsor:   Intrinsic Therapeutics
  Active, not recruiting
• Evaluating Bactisure Wound Lavage in Orthopedic Wounds

  NCT03192124

  Condition:   Infection of Total Knee Joint Prosthesis
  Intervention:   Device: Bactisure
  Sponsor:   Zimmer Biomet
  Completed
• The PATH Home Trial: A Comparative Effectiveness Study of Peripartum Opioid Use Disorder in Rural Kentucky

  NCT03725332

  Condition:   Neonatal Abstinence Syndrome
  Interventions:   Behavioral: Telemedicine;   Behavioral: Group Care
  Sponsors:   Wendy F Hansen;   Patient-Centered Outcomes Research Institute
  Recruiting
• A Study of Ocrelizumab in Participants With Relapsing Remitting Multiple Sclerosis (RRMS) Who Have Had a Suboptimal Response to an Adequate Course of Disease-Modifying Treatment (DMT)

  NCT02637856

  Condition:   Multiple Sclerosis, Relapsing-Remitting
  Intervention:   Drug: Ocrelizumab
  Sponsor:   Genentech, Inc.
  Active, not recruiting
• HEALing Communities Study

  NCT04111939

  Condition:   Opioid Use Disorder (OUD)
  Interventions:   Other: Communities That HEAL;   Other: Wait-list control
  Sponsors:   RTI International;   Boston Medical Center;   Columbia University;   Ohio State University;   University of Kentucky;   National Institute on Drug Abuse (NIDA);   Substance Abuse and Mental Health Services Administration (SAMHSA)
  Active, not recruiting
• Retrospective Review of the Cook Biodesign® Fistula Plug to Treat Anorectal Fistulas

  NCT03321266

  Condition:   Anorectal Fistula
  Intervention:   Device: Cook Biodesign® Fistula Plug
  Sponsor:   Cook Group Incorporated
  Completed
• A Phase 1/2 Open-Label, Dose Escalation Study to Determine the Optimal Dose, Safety, and Activity of AAV2hAQP1 in Subjects With Radiation-Induced Parotid Gland Hypofunction and Xerostomia

  NCT04043104

  Conditions:   Radiation-Induced Parotid Gland Hypofunction;   Xerostomia Due to Radiotherapy;   Head and Neck Cancer
  Intervention:   Drug: intra-parotid administration of AAV2hAQP1
  Sponsor:   MeiraGTx UK II Ltd
  Recruiting
• Traditional Versus Early Aggressive Therapy for Multiple Sclerosis Trial

  NCT03500328

  Condition:   Multiple Sclerosis, Relapsing-Remitting
  Intervention:   Other: Early Aggressive Therapy or Traditional Therapy
  Sponsors:   Johns Hopkins University;   Patient-Centered Outcomes Research Institute
  Recruiting
• AMPLATZER PFO Occluder Post Approval Study

  NCT03309332

  Conditions:   Stroke;   Patent Foramen Ovale
  Intervention:   Device: AMPLATZER™ PFO Occluder
  Sponsor:   Abbott Medical Devices
  Recruiting
• A Clinical Study to Evaluate the Safety and Efficacy of Elagolix in Participants With Moderate to Severe Endometriosis-Associated Pain

  NCT03213457

  Condition:   Endometriosis
  Interventions:   Drug: Estradiol/Norethindrone Acetate;   Other: Placebo for Elagolix;   Drug: Elagolix;   Other: Placebo for E2/NETA
  Sponsor:   AbbVie
  Active, not recruiting
• Safety and Efficacy Study of PRV111 in Subjects With Oral Squamous Cell Carcinoma

  NCT03502148

  Condition:   Oral Squamous Cell Carcinoma
  Intervention:   Drug: PRV111 (Cisplatin Transmucosal System)
  Sponsor:   Privo Technologies
  Recruiting
• A Study to Evaluate Safety and Efficacy of SAGE-547 in Participants With Moderate Postpartum Depression (547-PPD-202C)

  NCT02942017

  Condition:   Postpartum Depression
  Interventions:   Drug: Placebo;   Drug: SAGE-547 90 μg/kg/h
  Sponsor:   Sage Therapeutics
  Completed
• A Study to Evaluate Efficacy and Safety of SAGE-547 in Participants With Severe Postpartum Depression (547-PPD-202B)

  NCT02942004

  Condition:   Postpartum Depression
  Interventions:   Drug: Placebo;   Drug: SAGE-547 60 μg/kg/h;   Drug: SAGE-547 90 μg/kg/h
  Sponsor:   Sage Therapeutics
  Completed
• IMplementation of an RCT to imProve Treatment With Oral AntiCoagulanTs in Patients With Atrial Fibrillation

  NCT03259373

  Conditions:   Atrial Fibrillation;   Stroke
  Interventions:   Behavioral: Early Intervention;   Behavioral: Delayed Intervention
  Sponsors:   Harvard Pilgrim Health Care;   Duke Clinical Research Institute;   HealthCore, Inc.;   Clinical Trials Transformation Initiative;   Humana, Inc. - Comprehensive Health Insights;   Aetna, Inc.;   OptumInsight Life Sciences, Inc.;   Food and Drug Administration (FDA)
  Active, not recruiting
• A Proof of Concept Study to Evaluate CN-105 in ICH Patients

  NCT03168581

  Condition:   Intracerebral Hemorrhage
  Intervention:   Drug: CN-105
  Sponsors:   AegisCN LLC;   Duke Clinical Research Institute;   PharPoint Research, Inc.
  Completed
• Dose Ranging Study to Assess the Efficacy and Safety of Voclosporin Ophthalmic Solution in Subjects With Dry Eye Syndrome

  NCT04147650

  Conditions:   Dry Eye Syndrome;   Keratoconjunctivitis Sicca
  Interventions:   Drug: 0.05% Voclosporin Ophthalmic Solution (VOS);   Drug: 0.10% VOS;   Drug: 0.20% VOS;   Drug: Vehicle Ophthalmic Solution
  Sponsor:   Aurinia Pharmaceuticals Inc.
  Recruiting
• A Phase 2 Study to Evaluate the Efficacy and Safety of Erenumab (AMG 334) in Migraine Prevention

  NCT01952574

  Condition:   Migraine
  Interventions:   Drug: Erenumab;   Drug: Placebo
  Sponsor:   Amgen
  Completed
• A Study of Retreatment With Brentuximab Vedotin in Subjects With Classic Hodgkin Lymphoma or CD30-expressing Peripheral T Cell Lymphoma

  NCT03947255

  Conditions:   Hodgkin Lymphoma;   Peripheral T Cell Lymphoma;   Anaplastic Large Cell Lymphoma
  Intervention:   Drug: brentuximab vedotin
  Sponsor:   Seattle Genetics, Inc.
  Recruiting
• A Study of Ocrelizumab in Comparison With Interferon Beta-1a (Rebif) in Participants With Relapsing Multiple Sclerosis

  NCT01412333

  Condition:   Relapsing Multiple Sclerosis
  Interventions:   Drug: Interferon beta-1a;   Drug: Ocrelizumab-matching placebo;   Drug: Ocrelizumab;   Drug: Interferon beta-1a-matching placebo
  Sponsor:   Hoffmann-La Roche
  Active, not recruiting
• A Two-year Open-label Extension Study of Ganaxolone in Patients With Drug-resistant Partial-onset Seizures

  NCT02519439

  Condition:   Drug Resistant Partial Onset Seizure
  Intervention:   Drug: ganaxolone
  Sponsor:   Marinus Pharmaceuticals
  Terminated
• Legion Primary S & E

  NCT04040985

  Conditions:   Osteo Arthritis Knee;   Total Knee Replacement
  Intervention:   Procedure: Total Knee Arthroplasty using Legion Total Knee System
  Sponsor:   Smith & Nephew, Inc.
  Active, not recruiting
• Study of GBR 1302 (CD3 Bispecific Ab) in HER2-positive Metastatic Breast Cancer

  NCT03983395

  Condition:   Breast Cancer
  Interventions:   Biological: GBR 1302 250 ng/kg;   Biological: GBR 1302 325 ng/kg;   Biological: GBR 1302 325 ng/kg-D1;425 ng/kg -D8,D15,D22;   Biological: GBR 1302 325 ng/kg-D1;550 ng/kg -D8,D15,D22;   Biological: GBR1302 325ng/kgD1;550 ng/kg D8;700 ng/kgD15,22;   Biological: GBR1302 325ng/kg D1;550 ng/kg D8;900 ng/kg D15,22;   Biological: GBR1302 escalating doses,1200 ng/kg D15,22;   Biological: GBR1302 at the MTD and/or RP2D dose
  Sponsor:   Glenmark Pharmaceuticals S.A.
  Recruiting