JoinClinicalTrials.com

Results

Hot

Post your clinical trial on JoinClinicalTrials.com

Ellijay, Georgia 30536
United States

Post your clinical trial on JoinClinicalTrials.com to reach thousands of viewer daily. Our Clinical Trial Listings have consistently proven to be an ...

• Neurobehavioral Mechanisms of Choice in Opioid Use Disorder

  NCT03958474

  Condition:   Opioid Use Disorder
  Intervention:   Drug: Oxycodone
  Sponsor:   Joshua A. Lile, Ph.D.
  Recruiting
• Behavioral Effects of Drugs (Inpatient): 38

  NCT03954938

  Condition:   Cocaine Use, Unspecified
  Interventions:   Behavioral: Craving Manipulation;   Drug: Cocaine;   Drug: Placebo
  Sponsor:   William Stoops
  Recruiting
• Neural Mechanisms of Cannabinoid-impaired Decision-Making in Emerging Adults

  NCT03944954

  Conditions:   Neurosciences;   Substance-Related Disorders;   Behavior Problem
  Interventions:   Drug: Marinol;   Device: Transcranial Magnetic Stimulation
  Sponsor:   University of Kentucky
  Recruiting
• Fetal Life: Smart-Device Based Uterine Activity Monitoring

  NCT03940365

  Conditions:   Labor Pain;   Contraction
  Intervention:   Device: Fetal Life tocometer device
  Sponsors:   Fetal Life LLC;   University of Louisville
  Not yet recruiting
• Suvorexant and Cocaine

  NCT03937986

  Condition:   Cocaine Use Disorder
  Interventions:   Drug: Suvorexant;   Drug: Cocaine;   Drug: Placebo oral capsule
  Sponsors:   William Stoops;   National Institute on Drug Abuse (NIDA)
  Recruiting
• Role of ASpirin in Placental and Maternal Endothelial Cell Regulation IN Pre-eclampsia

  NCT03893630

  Condition:   Pre-Eclampsia
  Interventions:   Drug: Acetylsalicylic Acid 81 mg;   Drug: Acetylsalicylic Acid 162 mg;   Other: Control
  Sponsor:   John O'Brien, MD
  Recruiting
• Assessment of Gut Absorption of Experimental Medication BMS-986165 in Healthy Males

  NCT03873415

  Condition:   Psoriasis
  Intervention:   Drug: BMS-986165
  Sponsor:   Bristol-Myers Squibb
  Recruiting
• Transvaginal Ultrasound: Preterm Birth in Appalachia

  NCT03833284

  Condition:   Preterm Birth
  Interventions:   Behavioral: Participant Barriers to TVU Screening;   Behavioral: Provider Barriers to TVU Screening
  Sponsor:   Niraj Chavan
  Recruiting
• Opioid and Cannabinoid Interactions

  NCT03705559

  Conditions:   Marijuana Usage;   Opioid Use
  Interventions:   Drug: Vaporized Marijuana;   Drug: Opioid Agonist
  Sponsor:   Shanna Babalonis, PhD
  Recruiting
• Marijuana Effects on Simulated Driving Performance

  NCT03699540

  Conditions:   Cannabis;   Cannabis Use;   Marijuana;   Marijuana Usage;   Alcohol Drinking
  Interventions:   Drug: Marijuana;   Drug: Alcohol
  Sponsor:   Shanna Babalonis, PhD
  Recruiting
• Functional and Self-reported Outcomes in Participants With a History of Musculoskeletal Knee Injury

  NCT03617991

  Conditions:   Anterior Cruciate Ligament Injury;   Anterior Cruciate Ligament Rupture
  Intervention:   Other: Exercise Group
  Sponsor:   Johanna M. Hoch
  Recruiting
• Behavioral Effects of Drugs: Inpatient (35)

  NCT03519022

  Condition:   Cocaine Use Disorder
  Interventions:   Drug: Cocaine;   Drug: Placebo oral capsule;   Drug: Methylphenidate
  Sponsors:   Craig Rush;   National Institute on Drug Abuse (NIDA)
  Completed
• The Role of Physical Activity During Pregnancy on Metabolic Function, Inflammation, and Maternal and Neonatal Outcomes

  NCT03504319

  Conditions:   Obesity;   Pregnancy Related
  Intervention:   Other: Exposure to high-fat smoothie
  Sponsor:   Western Kentucky University
  Active, not recruiting
• Evidence-based Educational Materials and Local Resources for Improving Exercise-related Outcomes During Pregnancy

  NCT03504267

  Conditions:   Pregnancy Related;   Obesity
  Intervention:   Other: Physical Activity Education and Resources
  Sponsor:   Western Kentucky University
  Active, not recruiting
• Subacute Low Back Pain in Active Duty

  NCT03502187

  Condition:   Subacute Low Back Pain
  Interventions:   Behavioral: Progressive Exercise Plan;   Device: NeuromuscularElectricalStimulation(NMES);   Behavioral: Primary Care Management (PCM)
  Sponsors:   University of Tennessee;   Blanchfield Army Community Hospital
  Recruiting
• Tobacco Use in Pregnancy Intervention for Cessation

  NCT03442530

  Condition:   Pregnancy
  Interventions:   Behavioral: ToPIC;   Behavioral: Tobacco Treatment As Usual (TTAU)
  Sponsors:   Kristin Ashford;   University of Kentucky
  Active, not recruiting
• To Investigate the Gastrointestinal Behaviour of Two Triple Combination Products in Healthy Male Volunteers

  NCT03415243

  Condition:   Common Cold
  Interventions:   Drug: Acetaminophen 650mg+Dextromethorphan 20mg+Phenylephrine 10mg;   Drug: Acetaminophen 325mg+Dextromethorphan 10mg+Phenylephrine 5mg
  Sponsor:   GlaxoSmithKline
  Completed
• Exercise and Weight Control

  NCT03413826

  Conditions:   Obesity;   Exercise Reinforcement
  Intervention:   Behavioral: Exercise
  Sponsor:   University of Kentucky
  Completed
• Sedative-Anxiolytic Effects on Simulated Driving Performance

  NCT03297944

  Condition:   Psychomotor Impairment
  Interventions:   Drug: Alprazolam;   Drug: Zolpidem;   Drug: Placebo
  Sponsors:   Marion Coe;   National Institute on Drug Abuse (NIDA)
  Completed
• Influence of n-Acetylcysteine Maintenance on Alcohol Effects

  NCT03216954

  Condition:   Alcohol Use Disorder
  Interventions:   Drug: Alcohol;   Drug: Placebos;   Drug: N-acetyl cysteine
  Sponsors:   William Stoops;   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
  Recruiting
• Dietary Sources of Lysophospholipids

  NCT02952638

  Conditions:   Obesity;   Cardiovascular Risk Factor;   Hyperlipidemia
  Intervention:  
  Sponsor:   University of Kentucky
  Recruiting
• Multi-College Bystander Efficacy Evaluation

  NCT02659423

  Condition:   Sexual Violence
  Interventions:   Behavioral: BIC 1;   Behavioral: BIC 2;   Behavioral: BIC 3
  Sponsors:   Ann Coker;   Centers for Disease Control and Prevention
  Enrolling by invitation
• Trial of Self-managed Approaches for Patellofemoral Pain Syndrome in Active Duty

  NCT02597673

  Condition:   Patellofemoral Pain Syndrome
  Interventions:   Other: Home Exercise Program (HEP);   Device: NMES;   Device: TENS
  Sponsors:   University of Tennessee;   Blanchfield Army Community Hospital
  Completed
• Cold Induced Changes in White Adipose

  NCT02596776

  Conditions:   Obese;   Normal Body Weight;   Prediabetes;   Metabolic Syndrome
  Interventions:   Procedure: Fat biopsy;   Drug: Propranolol and fat biopsy;   Other: heavy water and fat biopsy
  Sponsors:   Philip Kern;   National Institutes of Health (NIH)
  Recruiting
• Impact of Electronic Cigarettes on Perinatal Immune Responsiveness and Birth Outcomes

  NCT02553577

  Conditions:   Immune Response;   Birth Weight;   Gestational Age
  Intervention:  
  Sponsors:   Kristin Ashford;   Virginia Commonwealth University
  Recruiting
• Reinforcing Effects of Cocaine During Phendimetrazine Maintenance

  NCT02522325

  Condition:   Cocaine Use Disorder
  Interventions:   Drug: Phendimetrazine;   Drug: Cocaine;   Drug: Placebo
  Sponsors:   William Stoops;   National Institute on Drug Abuse (NIDA)
  Completed
• Impact of Sustained Release d-Amphetamine on Choice Between Cocaine and a Non-Drug Reinforcer

  NCT02383043

  Condition:   Active Cocaine Users
  Interventions:   Drug: Cocaine;   Drug: Sustained Release d-Amphetamine
  Sponsor:   Joshua A. Lile, Ph.D.
  Completed
• Impact of a Non-Drug Choice on Cocaine Reinforcement

  NCT01906346

  Condition:   Cocaine Dependence
  Interventions:   Drug: Cocaine;   Drug: Placebo
  Sponsor:   Joshua A. Lile, Ph.D.
  Completed
• Behavioral Effects of Pregabalin and Cannabis

  NCT01511640

  Condition:   Cannabis-use Disorders
  Interventions:   Drug: Pregabalin;   Drug: Placebo
  Sponsor:   Joshua A. Lile, Ph.D.
  Recruiting
• Evaluate Retention of an Orally Administered Device Using Gamma Scintigraphy Study 2

  NCT00780286

  Condition:   Healthy Subjects
  Interventions:   Device: Polymer based lubricating liquid;   Device: Moi-Stir
  Sponsor:   Procter and Gamble
  Completed
• Evaluate Retention of an Orally Administered Device Using Gamma Scintigraphy

  NCT00754091

  Condition:   Healthy Subjects
  Intervention:   Device: Polymer based lubricating liquid
  Sponsor:   Procter and Gamble
  Completed
• Redefining Survivorship: POWER to Maximize Physical Function for Survivors of Critical Illness

  NCT04058977

  Conditions:   Critical Illness;   Muscle Atrophy or Weakness
  Intervention:   Other: Power training
  Sponsors:   University of Kentucky;   Nathan Johnson, PT, PhD;   Ashley Montgomery-Yates, MD;   Amy Pastva, PT, PhD;   Peter E. Morris, MD
  Not yet recruiting
• A Study to Evaluate the Safety and Effectiveness Assessments of Restylane-Defyne for Punctual Occlusion

  NCT04022382

  Condition:   Dry Eye
  Intervention:   Device: Restylane Defyne
  Sponsor:   John C Meyer, MD
  Enrolling by invitation
• Total Knee Replacement With Tourniquet or Aquamantys

  NCT04016285

  Condition:   Knee Replacement
  Interventions:   Device: Aquamantys;   Device: Tourniquet
  Sponsors:   Stephen Duncan;   Medtronic
  Recruiting
• Hydroxychloroquine to Increase Tumor Suppressor PAR-4 Levels in Oligometastatic Prostate Cancer

  NCT04011410

  Condition:   Prostate Cancer Recurrent
  Intervention:   Drug: Hydroxychloroquine Sulfate 200Mg Tab
  Sponsor:   University of Kentucky
  Not yet recruiting
• Testing a Smart Phone App to Enhance Voice Therapy Adherence

  NCT04002336

  Condition:   Voice Disorders
  Interventions:   Behavioral: Traditional Voice therapy;   Behavioral: Voice Therapy App
  Sponsor:   Vrushali Angadi
  Completed
• Effects of 5HTP and LDOPA on CNS Excitability After SCI

  NCT04000919

  Condition:   Spinal Cord Injuries
  Interventions:   Drug: 5HTP;   Drug: L-DOPA;   Drug: Placebo oral tablet;   Drug: Carbidopa
  Sponsor:   Jessica M D'Amico
  Recruiting
• Non-Invasive Spinal Cord Stimulation After Injury

  NCT03998527

  Condition:   Spinal Cord Injuries
  Intervention:   Device: Transcutaneous Electrical Spinal Cord Stimulation (TcESCS)
  Sponsor:   University of Louisville
  Recruiting
• Study of Lumbar Discectomy With Annular Closure

  NCT03986580

  Condition:   Lumbar Disc Herniation
  Intervention:   Device: BARRICAID device
  Sponsor:   Intrinsic Therapeutics
  Not yet recruiting
• Combination Rucaparib With Nivolumab in Small Cell Lung Carcinoma

  NCT03958045

  Condition:   Small Cell Lung Cancer
  Intervention:   Combination Product: Rucaparib and Nivolumab
  Sponsor:   Aman Chauhan
  Not yet recruiting
• Improving Hand Recovery With Neuromodulation in Tetraplegia

  NCT03954496

  Conditions:   Spinal Cord Injuries;   Tetraplegia, Unspecified, Incomplete, Chronic
  Interventions:   Device: transcranial direct current stimulation;   Behavioral: Intensive upper extremity motor training
  Sponsors:   University of Kentucky;   Wings for Life - spinal cord research foundation
  Recruiting
• Better Together: A Web-based Relationship Education Tool

  NCT03953495

  Condition:   Same-Sex Relationships
  Interventions:   Behavioral: Better Together;   Behavioral: Better Together (delayed)
  Sponsor:   Sharon Scales Rostosky
  Recruiting
• The Kentucky Viral Hepatitis Treatment Study

  NCT03949764

  Conditions:   Hepatitis C;   Opioid-Related Disorders;   Injection Drug Use
  Intervention:   Drug: Sofosbuvir/velpatasvir (Epclusa®)
  Sponsors:   Jennifer Havens;   National Institute on Drug Abuse (NIDA);   National Cancer Institute (NCI);   Gilead Sciences;   University of Kentucky;   Icahn School of Medicine at Mount Sinai;   University of Bristol
  Not yet recruiting
• Tourniquet vs. Short Time Tourniquet in Primary Robotic Assisted TKA

  NCT03942939

  Condition:   Knee Arthropathy
  Interventions:   Other: Primary Robotic-Assisted Total Knee Arthroplasty with a short tourniquet time;   Other: Primary Robotic-Assisted Total Knee Arthroplasty with the use of a tourniquet
  Sponsor:   University of Louisville
  Not yet recruiting
• Imaginal Exposure II Study: In-Vivo

  NCT03934697

  Conditions:   Eating Disorder;   Anorexia Nervosa;   Bulimia Nervosa;   Exposure
  Intervention:   Behavioral: imaginal exposure therapy
  Sponsor:   University of Louisville
  Recruiting
• Gentamicin Bladder Instillation in Individuals With Spinal Cord Injury Having Chronic Urinary Tract Infections

  NCT03931408

  Conditions:   Neurogenic Bladder;   Spinal Cord Injuries
  Interventions:   Drug: Gentamicin Sulfate;   Other: Placebo instillation (saline alone);   Other: No instillation
  Sponsor:   University of Louisville
  Recruiting
• DUR-928 in Patients With Alcoholic Hepatitis

  NCT03917407

  Condition:   Alcoholic Hepatitis
  Interventions:   Drug: DUR-928 (Moderate AH);   Drug: DUR-928 (Severe AH)
  Sponsors:   Craig James McClain;   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
  Not yet recruiting
• Durvalumab and Tremelimumab Combination in Somatically Hypermutated Recurrent Solid Tumors

  NCT03911557

  Condition:   Tumor, Solid
  Intervention:   Drug: Durvalumab and Tremelimumab
  Sponsor:   John L. Villano, MD, PhD
  Recruiting
• Intramedullary Bone Grafting for Open Tibial Shaft Fractures

  NCT03891888

  Conditions:   Tibial Fractures;   Nonunion of Fracture;   Delayed Union of Fracture
  Intervention:   Procedure: Intramedullary Bone Graft
  Sponsor:   University of Louisville
  Not yet recruiting
• Clinical Trial on the Preventive Effect of Intravaginal Prasterone on Recurrent Urinary Tract Infections in Postmenopausal Women

  NCT03854396

  Conditions:   Recurrent Urinary Tract Infection;   Postmenopause;   Postmenopausal Syndrome;   Postmenopausal Symptoms;   Menopause
  Interventions:   Drug: Prasterone;   Drug: Placebo
  Sponsors:   Olivia Cardenas-Trowers, M.D.;   AMAG Pharmaceuticals, Inc.
  Not yet recruiting
• ACB + IPACK Block With or Without Local Infiltration in RA-TKA

  NCT03840122

  Condition:   Knee Arthropathy
  Interventions:   Other: ACB + IPACK block with injection of local anesthetic;   Other: ACB + IPACK block without injection
  Sponsor:   University of Louisville
  Not yet recruiting
• Impact of SPEAC® System Data on Therapeutic Decisions Related to Convulsive Seizure Patients With a New Diagnosis

  NCT03742661

  Condition:   Epilepsy
  Intervention:   Device: SPEAC System
  Sponsor:   Brain Sentinel
  Active, not recruiting
• Treatment of FUS-Related ALS With Betamethasone - The TRANSLATE Study

  NCT03707795

  Condition:   Familial Amyotrophic Lateral Sclerosis
  Intervention:   Drug: Betamethasone sodium phosphate/betamethasone acetate (Celestone® Soluspan®), 30 mg IM once a day for four days
  Sponsor:   University of Kentucky
  Recruiting
• CAMS-G Group Therapy for Suicidal Veterans

  NCT03682406

  Condition:   Suicide and Self-harm
  Intervention:   Behavioral: CAMS-G
  Sponsors:   Louisville VA Medical Center;   Rocky Mountain MIRECC for Suicide Prevention
  Recruiting
• The ASTERS Study: Assessing the Role of Sphingolipids in AcuTE Respiratory Distress Syndrome (ARDS)

  NCT03654352

  Conditions:   Acute Lung Injury;   Acute Respiratory Distress Syndrome
  Intervention:  
  Sponsor:   University of Kentucky
  Recruiting
• Proximal Humerus Fractures: A Retrospective Analysis

  NCT03637608

  Condition:   Proximal Humeral Fracture
  Intervention:  
  Sponsor:   The Orthopaedic Research & Innovation Foundation
  Active, not recruiting
• Posterior Approach to Total Shoulder Arthroplasty

  NCT03623269

  Conditions:   Total Shoulder Arthroplasty;   Osteo Arthritis Shoulders
  Intervention:   Procedure: posterior approach to total shoulder arthroplasty
  Sponsor:   The Orthopaedic Research & Innovation Foundation
  Active, not recruiting
• Does Depth of Neuromuscular Blockade (NMB) Affect Surgical Conditions in Obese Patients Undergoing Robotic Surgery

  NCT03591289

  Conditions:   GYN Disorders;   Urologic Diseases
  Intervention:   Drug: NMB with rocuronium bromide
  Sponsor:   Rainer Lenhardt
  Recruiting
• Building Stronger Allies

  NCT03571750

  Conditions:   Suicide;   Risk Reduction
  Interventions:   Behavioral: Building Stronger Allies;   Behavioral: Health Education Training
  Sponsor:   Florida State University
  Recruiting
• Tanglewood to Table: A Walking Farmer's Market Group and Control

  NCT03567252

  Condition:   Dietary Habits
  Intervention:   Behavioral: Walking Group
  Sponsors:   Dawn Brewer;   National Institute of Environmental Health Sciences (NIEHS)
  Completed
• Teachable Moment Brief Intervention for Veterans Following a Suicide Attempt

  NCT03533075

  Condition:   Suicide, Attempted
  Intervention:   Behavioral: Teachable Moment Brief Intervention
  Sponsors:   Louisville VA Medical Center;   University of Louisville
  Active, not recruiting
• Idiopathic Parkinson's Progression and Dopamine Transporter SPECT

  NCT03531086

  Condition:   Parkinson Disease
  Intervention:   Drug: Ioflupane I 123
  Sponsor:   Julie Gurwell
  Recruiting
• Tanglewood Trail Walking Program in Rural Kentucky

  NCT03495648

  Condition:   Dietary Habits
  Interventions:   Behavioral: walking group led by a community organizer;   Behavioral: Drive
  Sponsors:   Dawn Brewer;   National Institute of Environmental Health Sciences (NIEHS)
  Active, not recruiting
• A 14 Weeks Longitudinal Study to Investigate the Effect of Leukocyte- Platelet Rich Fibrin Plug on the Quality of the Newly Formed Bone in Ridge Preservation Procedure Following a Tooth Extraction. It is a Clinical, Radiographic and Histomorphometric Study.

  NCT03487718

  Conditions:   Alveolar Ridge Preservation;   Tooth Extraction
  Interventions:   Biological: Leukocyte platelet rich fibrin plug + d-PTFE membrane;   Biological: d-PTFE membrane
  Sponsor:   Firas Al Yafi
  Recruiting
• BerryCare: A Community Engagement Program

  NCT03477305

  Condition:   Cardiovascular Risk Factor
  Intervention:   Behavioral: Blackberry Consumption
  Sponsors:   Dawn Brewer;   National Institute of Environmental Health Sciences (NIEHS)
  Completed
• Clinic to Community Navigation to Improve Diabetes Outcomes

  NCT03474731

  Condition:   Diabetes Mellitus
  Interventions:   Behavioral: Diabetes Self Management Program;   Behavioral: Tailored Patient Navigation (PN) only;   Behavioral: DSMP AND Tailored Patient Navigation
  Sponsor:   Nancy Schoenberg
  Recruiting
• Clinical Trial Comparing Two Bladder Instillations for IC/BPS

  NCT03463915

  Conditions:   Interstitial Cystitis;   Bladder Pain Syndrome
  Interventions:   Drug: Bladder instillation WITH triamcinolone acetonide;   Drug: Bladder instillation WITHOUT triamcinolone acetonide
  Sponsor:   Olivia Cardenas-Trowers, M.D.
  Recruiting
• Social Media HIV Prevention Intervention for High Risk Rural Women

  NCT03456453

  Condition:   HIV/AIDS
  Intervention:   Behavioral: NIDA Standard for HIV Prevention
  Sponsors:   University of Kentucky;   National Institute on Drug Abuse (NIDA)
  Recruiting
• Study Investigating Role of Unalike Patient Positioning on PROMIS Scores

  NCT03446950

  Conditions:   Physical Activity;   Surgery;   Vaginal Hysterectomy;   Vaginal Surgery
  Intervention:   Procedure: Vaginal Surgery
  Sponsor:   University of Louisville
  Recruiting
• "Assessment of the Quality and Quantity of Bone Regeneration."

  NCT03417375

  Condition:   Bone Quality and Quantity
  Intervention:   Procedure: Bilateral Sinus Augmentation
  Sponsor:   University of Kentucky
  Active, not recruiting
• Task-specific Epidural Stimulation Study

  NCT03364660

  Condition:   Spinal Cord Injuries
  Interventions:   Device: Epidural Stimulation;   Biological: Stand Training
  Sponsor:   University of Louisville
  Recruiting
• Chemotherapy-Induced Cognitive Impairment in Ovarian Cancer Patients

  NCT03324945

  Condition:   Chemotherapy-induced Cognitive Impairment
  Intervention:   Behavioral: Neurocognitive assessments
  Sponsors:   University of Kentucky;   Office of US Army Medical Research and Material Command
  Active, not recruiting
• Priming Immunotherapy in Advanced Disease With Radiation

  NCT03313804

  Conditions:   Non-small Cell Lung Cancer;   Squamous Cell Carcinoma of the Head and Neck
  Interventions:   Drug: Immune checkpoint inhibitor;   Radiation: Radiation Therapy
  Sponsor:   John L. Villano, MD, PhD
  Recruiting
• Dysregulated CNS Inflammation After Acute Brain Injury

  NCT03287557

  Conditions:   Traumatic Brain Injury;   Aneurysmal Subarachnoid Hemorrhage
  Intervention:  
  Sponsor:   University of Kentucky
  Recruiting
• A Pilot Study Using Autologous Regulatory T Cell Infusion Zortress (Everolimus) in Renal Transplant Recipients

  NCT03284242

  Conditions:   End Stage Renal Disease;   Kidney Transplant
  Intervention:   Procedure: Apheresis
  Sponsors:   Roberto Gedaly;   Novartis Pharmaceuticals
  Recruiting
• Removable Partial Denture Abutments Restored With Monolithic Zirconia Crowns

  NCT03283709

  Conditions:   Crowns;   Denture
  Interventions:   Device: Full-contour monolithic zirconia abutment crowns;   Device: Conventional abutment crowns
  Sponsor:   University of Kentucky
  Recruiting
• Mantra Meditation in Subjects That Have Chronically Impaired Attention After Stroke

  NCT03229902

  Condition:   Stroke Sequelae
  Intervention:   Behavioral: mantra meditation
  Sponsor:   Cheryl Carrico
  Completed
• Cocaine Use Reduction and Health

  NCT03224546

  Condition:   Cocaine Use Disorder
  Intervention:   Behavioral: Contingency Management
  Sponsors:   William Stoops;   National Institute on Drug Abuse (NIDA)
  Recruiting
• Intraoperative Amiodarone to Prevent Atrial Fibrillation in Lung Transplant Patients

  NCT03221764

  Conditions:   Atrial Fibrillation;   Lung Transplant; Complications
  Interventions:   Drug: Amiodarone with CoSeal;   Device: CO2 driver
  Sponsor:   University of Louisville
  Completed
• Evaluation of the Efficacy and Safety of Bempedoic Acid (ETC-1002) 180mg When Added to PCSK9 Inhibitor Therapy

  NCT03193047

  Condition:   Hypercholesterolemia
  Interventions:   Drug: bempedoic acid 180mg;   Other: placebo;   Drug: evolocumab
  Sponsor:   Esperion Therapeutics
  Completed
• The Efficacy of Single Coil Defibrillation Leads for Internal Cardioversion of Atrial Fibrillation

  NCT03164395

  Condition:   Atrial Fibrillation
  Interventions:   Procedure: Internal Cardioversion;   Procedure: External Cardioversion
  Sponsor:   University of Kentucky
  Completed
• Blood And Clot Thrombectomy Registry And Collaboration

  NCT03153683

  Condition:   Acute Ischemic Stroke
  Intervention:   Other: Registry
  Sponsors:   Justin Fraser;   University of Kentucky
  Recruiting
• Vitamin D for Muscle Metabolic Function in Cancer Cachexia

  NCT03144128

  Conditions:   Cancer Cachexia;   Vitamin D Deficiency
  Interventions:   Dietary Supplement: Vitamin D;   Dietary Supplement: Placebo
  Sponsor:   David Travis Thomas
  Recruiting
• VITOM Study: A Randomized, Controlled Trial.

  NCT03120689

  Conditions:   Pelvic Organ Prolapse;   Prolapse of Vaginal Vault After Hysterectomy;   Bulging of Vaginal Wall;   Incontinence;   Fistula
  Interventions:   Other: Live Surgery using VITOM;   Other: Live Surgery without VITOM;   Other: Video viewing with VITOM;   Other: Video viewing with standard handheld high-definition camera
  Sponsors:   University of Louisville;   KARL STORZ Endoscopy-America, Inc.
  Completed
• The INFUSE Trial - Intervening With Platelet Transfusions in Sepsis

  NCT03090919

  Conditions:   Sepsis;   Thrombocytopenia
  Interventions:   Biological: Platelet transfusion;   Other: Saline
  Sponsor:   University of Kentucky
  Recruiting
• Evaluating Genomic Testing in Human Cancer & Outcomes of Targeted Therapies

  NCT03089554

  Condition:   Cancer
  Intervention:   Drug: Therapeutic Intervention
  Sponsor:   Rachel Miller
  Recruiting
• Video-Laryngoscope Alone or With Bronchoscope for Predicted Difficult Intubation

  NCT03080896

  Condition:   Intubation; Difficult
  Interventions:   Device: King Vision video-laryngoscope with #3 disposable blade and endotracheal tube stylet;   Device: fiberoptic bronchoscope aScope III
  Sponsors:   University of Louisville;   Ambu A/S
  Recruiting
• Rural Intervention for Caregivers' Heart Health

  NCT03068390

  Condition:   Cardiovascular Risk Factor
  Interventions:   Behavioral: RICHH Intervention;   Behavioral: Usual care
  Sponsors:   Debra Moser;   National Institute of Nursing Research (NINR)
  Recruiting
• Stem Cell Heart Injections During Laser Revascularization Surgery for Treatment of Chronic Ischemic Heart Disease

  NCT03043742

  Condition:   Chronic Ischemic Heart Disease
  Intervention:   Drug: Bone Marrow Derived Autologous CD133+ Selected Cell Product
  Sponsor:   Michael Sekela
  Recruiting
• Cangrelor in ST-Elevation Myocardial Infarction to Decrease Infarct Size

  NCT03043274

  Condition:   STEMI - ST Elevation Myocardial Infarction
  Intervention:   Drug: Cangrelor
  Sponsor:   George Bennet, MD
  Recruiting
• Fosbretabulin With Everolimus in Neuroendocrine Tumors With Progression

  NCT03014297

  Conditions:   Neuroendocrine Tumors;   Everolimus
  Interventions:   Drug: everolimus;   Drug: fosbretabulin
  Sponsor:   Lowell Anthony, MD
  Terminated
• Use of Apremilast in Patients Who Are Dissatisfied With Stable Maintenance Topical Therapy

  NCT03000309

  Condition:   Plaque Psoriasis
  Intervention:   Drug: Apremilast
  Sponsors:   Derm Research, PLLC;   Celgene
  Completed
• Brown Fat Activation Study

  NCT02919176

  Conditions:   Obese;   Metabolic Syndrome
  Interventions:   Drug: Mirabegron;   Drug: Pioglitazone;   Drug: Mirabegron and Pioglitazone
  Sponsors:   Philip Kern;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
  Recruiting
• Magnesium And Verapamil After Recanalization in Ischemia of the Cerebrum: a Clinical and Translational Study.

  NCT02912663

  Condition:   Ischemic Stroke
  Interventions:   Drug: Verapamil and Magnesium Sulfate;   Other: Placebo
  Sponsor:   Justin Fraser
  Recruiting
• Responsible Fatherhood Opportunities for Reentry & Mobility

  NCT02860988

  Condition:   Substance Use Disorders
  Intervention:   Behavioral: MCCC treatment
  Sponsors:   Mountain Comprehensive Care Center;   University of Kentucky
  Recruiting
• Hodgkin Lymphoma Molecular Profiling and Clinical Outcomes in U.S. Community Oncology Practices

  NCT02856646

  Condition:   Hodgkin's Disease
  Intervention:  
  Sponsor:   Bristol-Myers Squibb
  Recruiting
• Comparison of One-port and Two-port Tissue Expanders for Breast Reconstruction

  NCT02725801

  Condition:   Breast Cancer
  Interventions:   Device: Allergen one-port tissue expander placement;   Device: AlloX2 two-port tissue expander placement
  Sponsor:   Lesley Wong
  Recruiting
• Effect of Albumin Administration on Vasopressor Duration in Resolving Septic Shock

  NCT02716597

  Condition:   Shock, Septic
  Interventions:   Drug: 25% Albumin;   Drug: Placebo
  Sponsor:   Alexander Flannery, 859-323-4011
  Terminated
• Comparison of In-Person Versus Remote Cochlear Implant Candidacy Evaluations

  NCT02684175

  Conditions:   Hearing Loss;   Hearing Disorders
  Interventions:   Device: Remote CI Counseling;   Other: In-Person CI Counseling
  Sponsor:   University of Kentucky
  Active, not recruiting
• Percutaneous Nerve Evaluation With Fluoroscopy Versus Without

  NCT02677753

  Conditions:   Overactive Bladder;   Urinary Incontinence;   Fecal Incontinence
  Intervention:   Radiation: Fluoroscopy
  Sponsor:   University of Louisville
  Active, not recruiting
• Selective Surgical Staging for the Treatment of Endometrial Cancer Based on Intraoperative Consultation

  NCT02658565

  Condition:   Endometrial Cancer
  Intervention:   Procedure: Lymphadenectomy
  Sponsor:   Frederick R. Ueland, M.D.
  Recruiting
• QuitAdvisorDDS: A Point-of-Care Tobacco Cessation Tool for Dental Settings

  NCT02570646

  Condition:   Tobacco Use
  Intervention:   Behavioral: QA-DDS
  Sponsors:   Jamie Studts;   National Institute of Dental and Craniofacial Research (NIDCR);   University of Alabama at Birmingham;   The National Dental Practice-Based Research Network;   Health Decision Technologies, LLC
  Completed
• Renal Osteodystrophy: An Individual Management Approach

  NCT02440581

  Condition:   Kidney Failure, Chronic
  Interventions:   Drug: Alendronate;   Drug: Teriparatide;   Drug: Cinacalcet
  Sponsors:   Hartmut Malluche, MD;   Wright State University;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
  Recruiting
• Perfusion-Induced Hyperthermia for Metastatic Carcinoma

  NCT02409108

  Conditions:   Metastatic Non-Small Cell Lung Carcinoma;   Solid Tumor, Adult
  Intervention:   Device: Exatherm-TBH system
  Sponsors:   Jonathan Kiev;   Exatherm, Inc
  Completed
• Respiratory Motor Control and Blood Pressure Regulation After Spinal Cord Injury

  NCT02396823

  Condition:   Spinal Cord Injury
  Intervention:   Behavioral: Respiratory Muscle Training
  Sponsors:   University of Louisville;   National Heart, Lung, and Blood Institute (NHLBI)
  Active, not recruiting
• Effect of All-Stim 2 Quadriceps Treatments on Limb Muscle Strength In Mechanically Ventilated Patients

  NCT02332187

  Condition:   Weakness
  Interventions:   Device: Active electrical stimulation using an All Stim stimulator;   Device: Sham electrical stimulation using an All Stim stimulator
  Sponsor:   Gerald Supinski
  Recruiting
• Sildenafil in Heart Failure With Reactive Pulmonary Hypertension

  NCT02304705

  Condition:   Heart Failure With Reactive Pulmonary Hypertension
  Interventions:   Drug: Sildenafil;   Drug: Placebo
  Sponsor:   Maya Guglin
  Terminated
• Transcutaneous Spinal Stimulation: Safety and Feasibility for Upper Limb Function in Children With Spinal Cord Injury

  NCT04032990

  Condition:   Spinal Cord Injuries
  Intervention:   Device: Biostim-5 transcutaneous spinal stimulator
  Sponsors:   University of Louisville;   The Jewish Heritage Foundation for Excellence
  Not yet recruiting
• Treatment of Muscle Weakness in Critically Ill Patients

  NCT02247895

  Conditions:   Critical Illness;   Respiratory Failure;   Myopathy;   Weakness
  Interventions:   Device: Sham Treatment;   Device: Electrical stimulation
  Sponsor:   Gerald Supinski
  Terminated
• HCQ on PAR-4 Levels in Patients With Resectable Solid Tumors

  NCT02232243

  Condition:   Solid Tumor
  Interventions:   Drug: Hydroxychloroquine, 200mg twice dailiy;   Drug: Hydroxychloroquine, 400mg twice daily
  Sponsor:   Peng Wang, MD PhD
  Completed
• Evaluating the Performance of Morphology Index in Surgical Decision-Making for Ovarian Tumors

  NCT02227654

  Condition:   Ovarian Neoplasms
  Intervention:   Procedure: Abnormal Ovarian Ultrasound
  Sponsors:   Frederick R. Ueland, M.D.;   Lucille P. Markey Cancer Center at University of Kentucky
  Recruiting
• Valproic Acid and Dihydroergotamine as Abortive Therapy in Pediatric Migraine

  NCT03885154

  Condition:   Migraine in Children
  Interventions:   Drug: Valproic Acid (VPA);   Drug: Dihydroergotamine (DHE)
  Sponsor:   Kimberly S Jones
  Recruiting
• Assessment of Chiropractic Treatment Using Reaction and Response Times in Members of the Special Operation Forces (ACT2)

  NCT02168153

  Condition:   Physiological Measurements of Response and Reaction Times
  Interventions:   Other: Chiropractic Manipulative Therapy;   Other: Wait-list
  Sponsors:   RAND;   Palmer College of Chiropractic;   Samueli Institute for Information Biology
  Completed
• Mechanisms of Arterial Hypotension in Chronic Spinal Cord Injury

  NCT02154412

  Condition:   Spinal Cord Injury
  Intervention:   Other: Respiratory Training
  Sponsors:   University of Louisville;   The Craig H. Neilsen Foundation
  Active, not recruiting
• A Study of Chemo +/- Low-dose Radiation as Induction Therapy in SCCHN

  NCT02126969

  Conditions:   Head and Neck Cancer;   Larynx
  Interventions:   Radiation: Low dose fractionated radiation - 80cGy with chemotherapy;   Drug: Docetaxel and Carboplatin AUC 6
  Sponsor:   University of Kentucky
  Active, not recruiting
• Blood Lipopolysaccharide (LPS) Rifaximin Study

  NCT02124512

  Conditions:   Obese;   Insulin Resistance;   Metabolic Syndrome
  Interventions:   Drug: Rifaximin SSD;   Other: Placebo
  Sponsors:   Philip Kern;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
  Completed
• Randomized Study of Beet Root in Locally Advanced Squamous Cell Cancer of the Head and Neck

  NCT02058849

  Condition:   Mucositis
  Interventions:   Drug: Beetroot;   Other: Placebo
  Sponsor:   David Travis Thomas
  Completed
• Recovery of Cardiovascular Function With Epidural Stimulation After Human Spinal Cord Injury

  NCT02037620

  Condition:   Spinal Cord Injury
  Interventions:   Device: 5-6-5 Specify electrode;   Device: Restore Advance Pulse Generator
  Sponsor:   University of Louisville
  Active, not recruiting
• Neuro-ocular Baselines in a Sports Setting

  NCT03653936

  Condition:   Wave Form Signals Coming From the Eye in a Healthy Cohort
  Intervention:   Device: HITT device
  Sponsors:   Rebiscan, Inc.;   BlueGrass Orthopaedics Surgery & Hand Care
  Completed
• Cohort 2 Efficacy of Nasopharyngeal Ventilation With Endotracheal Tube for Surgery

  NCT02018146

  Condition:   General Anesthesia With Endotracheal Intubation in Surgery
  Interventions:   Other: Mask then nasopharyngeal;   Other: Nasopharyngeal then mask
  Sponsor:   University of Louisville
  Completed
• Skin Rash Study Before Chemotherapy in Colorectal & Head and Neck Cancer Patients

  NCT01874860

  Conditions:   Colorectal Cancer;   Head and Neck Cancer
  Interventions:   Drug: Doxycycline;   Drug: Hydrocortisone 1% cream;   Other: Sunscreen;   Other: Moisturizer;   Drug: Clindamycin;   Drug: Medrol-dose pack (Steroid)
  Sponsors:   University of Louisville;   James Graham Brown Cancer Center
  Recruiting
• Brief Intervention for Rural Women at High Risk for HIV/HCV

  NCT01840722

  Conditions:   Acquired Immune Deficiency Syndrome Virus;   Hepatitis C;   Drug Abuse
  Intervention:   Other: MI-based HIV Risk Reduction
  Sponsors:   Michele Staton;   National Institute on Drug Abuse (NIDA)
  Completed
• Therapeutic Equivalence Study of Generic Brinzolamide vs Azopt

  NCT01722604

  Conditions:   Glaucoma;   Open Angle or Ocular Hypertension
  Interventions:   Drug: brinzolamide 1% ophthalmic suspension;   Drug: Azopt 1%
  Sponsor:   Bausch Health Americas, Inc.
  Completed
• Edible Plant Exosome Ability to Prevent Oral Mucositis Associated With Chemoradiation Treatment of Head and Neck Cancer

  NCT01668849

  Conditions:   Head and Neck Cancer;   Oral Mucositis
  Interventions:   Dietary Supplement: Grape extract;   Drug: Lortab, Fentanyl patch, mouthwash
  Sponsors:   University of Louisville;   James Graham Brown Cancer Center
  Active, not recruiting
• Conformal High Dose Intensity Modulated Radiation Therapy for Disease to Thoracic and Lumbar Spine

  NCT01654068

  Condition:   Vertebral Metastasis
  Intervention:   Radiation: Conformal High Dose Intensity Modulated Radiation Therapy
  Sponsor:   Ronald McGarry
  Terminated
• IL-1RA Treatment in Patients With Acute ACL Tear and Painful Effusions

  NCT02930122

  Condition:   Anterior Cruciate Ligament Tear
  Interventions:   Drug: Saline (0.9%) and anakinra (150mg);   Drug: anakinra (150mg) and Saline (0.9%);   Other: Saline intraarticularly
  Sponsors:   Cale Jacobs, PhD;   Arthritis Foundation
  Recruiting
• Trial of Chemotherapy in Ovarian, Fallopian Tube and Peritoneal Carcinoma

  NCT01519869

  Conditions:   Primary Peritoneal Carcinoma;   Ovarian Carcinoma;   Fallopian Tube Carcinoma
  Intervention:   Drug: neoadjuvant chemotherapy
  Sponsor:   Rachel Miller
  Active, not recruiting
• ConnectEd: A Randomized Controlled Trial Connecting Through Educational Training

  NCT02786472

  Condition:   Sexual Violence
  Interventions:   Behavioral: Online Bystander Training;   Behavioral: Online Substance Abuse Training;   Behavioral: In-Person Bystander Training;   Behavioral: In-Person Combination Training
  Sponsors:   Heather Bush;   Centers for Disease Control and Prevention
  Active, not recruiting
• Feasibility Study of the TGI Adipose-derived Stromal Cell (ASC)-Coated ePTFE Vascular Graft

  NCT01305863

  Condition:   Lower Limb Ischemia
  Interventions:   Device: ASC coated ePTFE vascular graft;   Device: Propaten graft
  Sponsor:   Tissue Genesis, LLC
  Active, not recruiting
• Study Investigating the Ability of Plant Exosomes to Deliver Curcumin to Normal and Colon Cancer Tissue

  NCT01294072

  Condition:   Colon Cancer
  Interventions:   Dietary Supplement: curcumin;   Dietary Supplement: Curcumin conjugated with plant exosomes;   Other: No intervention
  Sponsors:   University of Louisville;   James Graham Brown Cancer Center
  Active, not recruiting
• Effect of EPA and HMB on Strength in ICU Patients

  NCT01270516

  Condition:   Muscle Weakness
  Interventions:   Drug: HMB, hydroxymethylbutyrate;   Drug: EPA, eicosapentaenoic acid;   Drug: Saline
  Sponsor:   Gerald Supinski
  Recruiting
• Evaluation of Green Dot a Primary Prevention Intervention

  NCT01878097

  Condition:   Sex Offenses
  Interventions:   Behavioral: Green Dot Bystander Intevention;   Behavioral: Control
  Sponsor:   University of Kentucky
  Completed
• Cardiovascular Biorepository

  NCT00753974

  Condition:   Cardiovascular Diseases
  Intervention:  
  Sponsor:   Kenneth S. Campbell
  Enrolling by invitation
• REVLIMID® (Lenalidomide) for Therapy of Radioiodine-Unresponsive Papillary and Follicular Thyroid Carcinomas

  NCT00287287

  Condition:   Thyroid Neoplasms
  Intervention:   Drug: Lenalidomide
  Sponsors:   Kenneth Ain;   Celgene Corporation
  Active, not recruiting
• Metabolomic Analysis of Lung Cancer

  NCT00263731

  Conditions:   Carcinoma, Non-Small Cell Lung;   Carcinoma, Small Cell Lung
  Intervention:   Other: 13-C-glucose
  Sponsors:   University of Louisville;   James Graham Brown Cancer Center
  Recruiting
• A Causative Role for Amylin in Diabetic Peripheral Neuropathy

  NCT03481283

  Conditions:   Type2 Diabetes;   Peripheral Neuropathy
  Intervention:  
  Sponsor:   John Slevin
  Recruiting
• Ovarian Tissue Freezing For Fertility Preservation In Women Facing A Fertility Threatening Medical Diagnosis/Treatment

  NCT02678910

  Conditions:   Cancer;   Hematologic Disorder;   Rheumatologic Disorder;   Infertility
  Intervention:   Procedure: Ovarian Cryopreservation
  Sponsor:   Vlad Radulescu
  Recruiting
• A Clinical Study to Evaluate the Clinical Performance and Safety of LiquiBand FIX8® Versus AbsorbaTack™ for Hernia Mesh Fixation and Peritoneal Closure in Groin Hernia Repair

  NCT04009213

  Conditions:   Hernia;   Inguinal Hernia;   Femoral Hernia;   Groin Hernia
  Interventions:   Device: LiquiBand FIX8®;   Device: AbsorbaTack™
  Sponsor:   Advanced Medical Solutions Ltd.
  Recruiting
• Epicutaneous Cryoimmunotherapy Combined With Pembrolizumab for Cutaneous Metastatic Breast Cancer

  NCT03982004

  Condition:   Metastatic Breast Cancer
  Interventions:   Device: Epicutaneous cryoimmunotherapy;   Drug: Topical imiquimod;   Drug: Pembrolizumab;   Other: Dermatologic Quality of Life Index;   Other: Functional Assessment of Cancer Therapy;   Drug: Intra-lesional GM-CSF;   Device: Cry-AC
  Sponsors:   Washington University School of Medicine;   Merck Sharp & Dohme Corp.
  Not yet recruiting
• Comparative Effectiveness of IIMR to the CDSMP

  NCT03966872

  Conditions:   Mental Illness;   Chronic Disease
  Interventions:   Behavioral: Integrated Illness Management and Recovery;   Behavioral: Chronic Disease Self-Management Program
  Sponsors:   Dartmouth-Hitchcock Medical Center;   Patient-Centered Outcomes Research Institute
  Not yet recruiting
• Clinical Trial to Evaluate the Efficacy of OC-02 Nasal Spray on Signs and Symptoms of Dry Eye Disease (The RAINIER Study)

  NCT03633461

  Condition:   Dry Eye Disease
  Interventions:   Drug: OC-02;   Drug: Placebo
  Sponsor:   Oyster Point Pharma, Inc.
  Completed
• Randomized Controlled Trial for Exparel Hip Fracture

  NCT03289858

  Condition:   Hip Fractures
  Interventions:   Drug: Exparel;   Drug: Sodium Chloride
  Sponsors:   University of Massachusetts, Worcester;   Orthopaedic Trauma Association;   University of Kentucky
  Completed
• A Study Investigating the Safety, Tolerability, and Efficacy of Elamipretide Topical Ophthalmic Solution for the Treatment of Fuchs' Corneal Endothelial Dystrophy (FCED)

  NCT02653391

  Condition:   Fuchs' Corneal Endothelial Dystrophy (FCED)
  Interventions:   Drug: Elamipretide 1.0% Ophthalmic Solution;   Drug: Elamipretide 3.0% Ophthalmic Solution
  Sponsor:   Stealth BioTherapeutics Inc.
  Completed
• A Safety and Efficacy Study of Tavilermide (MIM-D3) Ophthalmic Solution for the Treatment of Dry Eye

  NCT02634853

  Condition:   Keratoconjunctivitis Sicca
  Interventions:   Drug: 1% Tavilermide Ophthalmic Solution;   Drug: Placebo Ophthalmic Solution
  Sponsor:   Mimetogen Pharmaceuticals USA, Inc.
  Completed
• Evaluation of the Technical Success of IVUS Guided VCF Placement Using the LUMIFI™ With Crux® VCF System

  NCT02394912

  Conditions:   Pulmonary Embolism;   Deep Vein Thrombosis
  Intervention:   Device: vena cava filter implantation (LUMIFI with Crux VCF System)
  Sponsor:   Volcano Corporation
  Terminated
• A Registry Study of NanoKnife IRE for Stage 3 Pancreatic Cancer

  NCT03899649

  Condition:   Stage III Pancreatic Cancer
  Interventions:   Drug: SOC;   Device: NanoKnife System
  Sponsor:   Angiodynamics, Inc.
  Recruiting
• Tazemetostat and Pembrolizumab in Treating Patients With Locally Advanced or Metastatic Urothelial Carcinoma

  NCT03854474

  Conditions:   Advanced Urothelial Carcinoma;   Locally Advanced Urothelial Carcinoma;   Metastatic Bladder Urothelial Carcinoma;   Metastatic Urothelial Carcinoma;   PD-L1 Positive;   Stage III Bladder Cancer AJCC v8;   Stage IIIA Bladder Cancer AJCC v8;   Stage IIIB Bladder Cancer AJCC v8;   Stage IV Bladder Cancer AJCC v8;   Stage IVA Bladder Cancer AJCC v8;   Stage IVB Bladder Cancer AJCC v8
  Interventions:   Biological: Pembrolizumab;   Drug: Tazemetostat
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Bio2 Vitrium® Cervical Cage in Anterior Cervical Discectomy and Fusion

  NCT03828136

  Condition:   Symptomatic Cervical Disc Disease
  Interventions:   Device: Bio2 Vitrium® Cervical Interbody Device;   Device: Allograft Ring or Block
  Sponsors:   Bio2 Technologies;   Musculoskeletal Clinical Regulatory Advisers
  Recruiting
• EmboTrap® Revascularization Device Post Market Registry

  NCT03685578

  Condition:   Cerebral Stroke
  Intervention:   Device: EmboTrap® Revascularization Device
  Sponsor:   Neuravi Limited
  Recruiting
• Performance of MOTO Medial® Unicompartmental Knee Arthroplasty

  NCT03211663

  Conditions:   Knee Osteoarthritis;   Knee Arthritis;   Knee Pain Chronic
  Intervention:   Device: MOTO Medial® UKA
  Sponsor:   Medacta USA
  Recruiting
• Development and Feasibility Testing of a Lung Cancer Screening Decision Aid

  NCT02790866

  Condition:   Lung Neoplasms
  Interventions:   Behavioral: LuCaS Decision Aid;   Behavioral: NCI Website
  Sponsors:   Jamie Studts;   University of Miami
  Completed
• Using Media to Shift Social Norms of Violence Among Youth

  NCT02706145

  Condition:   Violence
  Intervention:   Other: Social norming campaign
  Sponsors:   University of Louisville;   Centers for Disease Control and Prevention;   Vanderbilt University
  Recruiting
• Adrenergic Cholinergic Enteric Measures/Mapping

  NCT04013282

  Condition:   Obesity
  Intervention:  
  Sponsor:   University of Louisville
  Recruiting
• Prospective, Multi-center Study to Assess Posterolateral Fusion Using FIBERGRAFT

  NCT03884283

  Conditions:   Degenerative Disc Disease;   Spondylolisthesis;   Spinal Stenosis Lumbar
  Intervention:   Device: FIBERGRAFT BG Matrix
  Sponsor:   Prosidyan, Inc.
  Enrolling by invitation
• Gastroparesis Outcome Longitudinal Database Enrolled Numerically

  NCT03876288

  Condition:   Gastroparesis
  Interventions:   Device: GI Neuromodulation;   Drug: Immunotherapy;   Procedure: Pyloric Therapies
  Sponsor:   University of Louisville
  Recruiting
• Elbow Arthroscopy Data Analysis

  NCT03656185

  Conditions:   Osteoarthritis Elbow Left;   Osteoarthritis Elbow Right;   Lateral Epicondylitis, Left Elbow;   Lateral Epicondylitis, Right Elbow;   Plica Syndromes;   Osteochondritis Dissecans
  Intervention:  
  Sponsor:   The Orthopaedic Research & Innovation Foundation
  Active, not recruiting
• Adaptation and Pilot Testing of a Behavioral Parent Training Program for Parents of Deaf and Hard of Hearing Children

  NCT03483428

  Conditions:   Hearing Loss;   Behavior Disorders;   Parenting
  Interventions:   Behavioral: Interventionist training and supervision;   Behavioral: Behavioral parent training
  Sponsor:   University of Kentucky
  Completed
• The Use of Oracea and Epiduo Forte in Severe Acne Patients

  NCT03457636

  Condition:   Acne
  Interventions:   Drug: Doxycycline Anhydrous 40 MG;   Drug: Adapalene/Benzoyl Peroxide Gel 0.3-2.5%
  Sponsor:   Derm Research, PLLC
  Completed
• The Use of Onexton in Moderate Acne Vulgaris for Patients With Skin of Color

  NCT03402893

  Conditions:   Acne Vulgaris;   Post Inflammatory Hyperpigmentation
  Intervention:   Drug: ONEXTON Topical Gel
  Sponsor:   Derm Research, PLLC
  Completed
• Telemedicine-based, Multidisciplinary-team, Intervention to Reduce Unnecessary Hospitalizations

  NCT03378245

  Conditions:   Dementia Alzheimers;   Disruptive Behavior
  Intervention:   Behavioral: Behavioral modification and education on pharmacologic treatments.
  Sponsor:   Richard Ronan Murphy
  Suspended
• Bracing Compliance and Personality Traits: A Compliance Assessment Program for Scoliosis and Clubfeet

  NCT02755766

  Conditions:   Clubfeet;   Adolescent Idiopathic Scoliosis
  Intervention:  
  Sponsor:   Shriners Hospitals for Children
  Active, not recruiting
• Systematically Adapted Delivery of the Family Check-Up

  NCT02709291

  Condition:   Parenting, Child Behavior, Implementation
  Interventions:   Behavioral: behavioral parent training;   Behavioral: interventionist training
  Sponsors:   Christina Studts;   National Institute of Mental Health (NIMH)
  Completed
• Communities Helping the Hearing of Infants by Reaching Parents

  NCT03875339

  Condition:   Congenital Hearing Loss
  Intervention:   Behavioral: Navigator Guidance
  Sponsors:   University of Kentucky;   National Institute on Deafness and Other Communication Disorders (NIDCD);   National Institutes of Health (NIH)
  Not yet recruiting
• Improving Adolescent Vaccination in Appalachian Kentucky

  NCT01838161

  Condition:   Adolescent Immunization
  Interventions:   Behavioral: Part II;   Behavioral: Part III;   Behavioral: Part I
  Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   Merck Sharp & Dohme Corp.;   University of Kentucky
  Completed
• Early Detection of Lung Cancer in a High-Risk Population Defined by PFT, Biomarkers, and CT Scanning

  NCT00596310

  Condition:   Lung Cancer
  Intervention:   Other: CT
  Sponsors:   Susanne Arnold;   Marty Driesler Cancer Project;   Kentucky Lung Cancer Research Program
  Active, not recruiting
• Inhaled Treprostinil in Patients With Pulmonary Hypertension Due to Chronic Obstructive Pulmonary Disease (PH-COPD)

  NCT03794583

  Conditions:   Pulmonary Hypertension;   Chronic Obstructive Pulmonary Disease
  Intervention:   Drug: Inhaled treprostinil solution
  Sponsors:   United Therapeutics;   Lung Biotechnology PBC
  Enrolling by invitation
• Clinical Trial to Evaluate the Efficacy of OC-02 Nasal Spray on Signs and Symptoms of Dry Eye Disease (The PEARL Study)

  NCT03452397

  Condition:   Dry Eye Disease (DED)
  Interventions:   Drug: OC-02;   Drug: Placebos
  Sponsor:   Oyster Point Pharma, Inc.
  Completed
• An Open-Label Study to Enable Continued Treatment Access for Subjects Previously Enrolled in Studies of Ruxolitinib

  NCT02955940

  Conditions:   Pancreatic Cancer;   Colorectal Cancer (CRC);   Breast Cancer;   Lung Cancer
  Interventions:   Drug: Ruxolitinib;   Drug: Capecitabine;   Drug: Regorafenib
  Sponsor:   Incyte Corporation
  Enrolling by invitation
• Evaluation of an Enhanced Delivery Model for Go NAPSACC

  NCT03938103

  Condition:   Obesity
  Interventions:   Behavioral: Enhanced Go NAPSACC;   Behavioral: Basic Go NAPSACC
  Sponsors:   University of North Carolina, Chapel Hill;   National Heart, Lung, and Blood Institute (NHLBI);   University of Kentucky;   Child Care Aware of Kentucky
  Recruiting
• The Peer-Based Retention of People Who Use Drugs in Rural Research

  NCT03885024

  Conditions:   Drug Use;   Peer Influence
  Intervention:   Other: Retention Video
  Sponsors:   Oregon Health and Science University;   University of Kentucky;   Ohio State University;   Emory University;   University of North Carolina
  Recruiting
• A Study to Assess Efficacy and Safety of HL036 in Subjects With Dry Eyes

  NCT03846453

  Condition:   Dry Eye
  Interventions:   Biological: 0.25% HL036 Ophthalmic Solution;   Biological: Placebo
  Sponsors:   HanAll BioPharma Co., Ltd.;   Daewoong Pharmaceutical Co. LTD.
  Recruiting
• Copanlisib Hydrochloride and Nivolumab in Treating Patients With Recurrent or Refractory Diffuse Large B-cell Lymphoma or Primary Mediastinal Large B-cell Lymphoma

  NCT03484819

  Conditions:   Recurrent Diffuse Large B-Cell Lymphoma;   Recurrent Primary Mediastinal (Thymic) Large B-Cell Cell Lymphoma;   Refractory Diffuse Large B-Cell Lymphoma;   Refractory Primary Mediastinal (Thymic) Large B-Cell Cell Lymphoma
  Interventions:   Drug: Copanlisib;   Drug: Copanlisib Hydrochloride;   Biological: Nivolumab
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Prospective Observational Study of Erythropoietin-Iron Interaction in Anemia of Renal Disease

  NCT01719146

  Condition:   Anemia of End Stage Renal Disease
  Intervention:   Other: Specimen collection
  Sponsors:   University of Louisville;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
  Active, not recruiting
• Assessment of the Long-Term Safety and Efficacy of Bempedoic Acid (CLEAR Harmony OLE)

  NCT03067441

  Conditions:   Hypercholesterolemia;   Atherosclerotic Cardiovascular Disease
  Intervention:   Drug: bempedoic acid
  Sponsor:   Esperion Therapeutics
  Active, not recruiting
• Outcomes Study of the TM Humeral Stem Used in Primary, Total or Hemi Shoulder Arthroplasty

  NCT01480453

  Conditions:   Osteoarthritis;   Rheumatoid Arthritis;   Post-traumatic Arthritis;   Ununited Humeral Head Fracture;   Irreducible 3- and 4-part Proximal Humeral Fractures;   Avascular Necrosis
  Intervention:   Device: Trabecular Metal Humeral Stem
  Sponsor:   Zimmer Biomet
  Terminated
• Phase 3 Study of OTX-101 in the Treatment of Keratoconjunctivitis Sicca

  NCT02688556

  Condition:   Keratoconjunctivitis Sicca
  Interventions:   Drug: cyclosporine;   Drug: vehicle of OTX-101
  Sponsor:   Sun Pharma Global FZE
  Completed
• Health Outcomes After Locomotor Training in Spinal Cord Injury

  NCT02201173

  Conditions:   Spinal Cord Injuries;   Spinal Cord Trauma
  Intervention:   Behavioral: Locomotor Training
  Sponsors:   Stony Brook University;   Ohio State University;   Kessler Institute for Rehabilitation;   TIRR Memorial Hermann;   University of Louisville;   Craig Hospital
  Completed
• A Study of the Safety, Pharmacokinetic Drug Interaction and Efficacy of ETC-1002 and Atorvastatin in Subjects With Hypercholesterolemia

  NCT01779453

  Condition:   Hypercholesterolemia
  Interventions:   Drug: ETC-1002;   Drug: Placebo;   Drug: Atorvastatin
  Sponsor:   Esperion Therapeutics
  Completed
• Continued Access to PREVAIL (CAP2) - WATCHMAN Left Atrial Appendage (LAA) Closure Technology

  NCT01760291

  Condition:   Atrial Fibrillation
  Intervention:   Device: WATCHMAN LAA Closure Technology
  Sponsor:   Boston Scientific Corporation
  Completed
• A Study of Eribulin in Combination With Oral Irinotecan for Adolescent and Young Adult Patients With Relapsed or Refractory Solid Tumors

  NCT02596503

  Conditions:   Relapsed Solid Tumors;   Refractory Solid Tumors
  Interventions:   Drug: Eribulin;   Drug: Irinotecan;   Other: Cefixime
  Sponsors:   University of Colorado, Denver;   University of Kentucky
  Active, not recruiting
• EVAHEART LVAS Bridge-to-Transplant Pivotal Study

  NCT01187368

  Condition:   Heart Failure
  Intervention:   Device: EVAHEART Left Ventricular Assist System (LVAS)
  Sponsor:   Evaheart, Inc.
  Recruiting
• Telepharmacy Robotic Medicine Delivery Unit "TRMDU" Assessment

  NCT01007006

  Conditions:   Traumatic Brain Injury;   Posttraumatic Stress Disorders;   Trauma;   Combat Disorders;   Pain
  Intervention:   Device: TMRDU
  Sponsors:   University of Illinois at Chicago;   U.S. Army Medical Research and Development Command
  Withdrawn
• A Phase 1/2, Randomized, Placebo-controlled, Observer-blinded Trial To Evaluate The Safety, Tolerability, And Immunogenicity Of A Multivalent Group B Streptococcus Vaccine In Healthy Adults 18 To 49 Years Of Age

  NCT03170609

  Condition:   Group B Streptococcal Infections
  Interventions:   Biological: Multivalent group B streptococcus vaccine;   Biological: Placebo
  Sponsor:   Pfizer
  Completed
• Safety and Immunogenicity of the Bris10 M2SR and Sing2016 M2SR H3N2 Monovalent Influenza Vaccines

  NCT03999554

  Condition:   Influenza A
  Interventions:   Biological: LD Sing2016 M2SR H3N2 influenza vaccine;   Biological: MD Sing2016 M2SR H3N2 influenza vaccine;   Biological: HD Sing2016 M2SR H3N2 influenza vaccine;   Biological: LD Bris10 M2SR H3N2 influenza vaccine;   Other: Placebo
  Sponsor:   FluGen Inc
  Not yet recruiting
• Panblok H7 Vaccine Adjuvanted With AS03 or MF59

  NCT03283319

  Condition:   Influenza, Human
  Interventions:   Biological: 3.75 ug Panblok H7;   Biological: 7.5 ug Panblok H7;   Biological: 15 ug Panblok H7;   Biological: MF59;   Biological: AS03
  Sponsors:   Biomedical Advanced Research and Development Authority;   Rho, Inc.
  Completed
• Axillary Reverse Mapping in Preventing Lymphedema in Patients With Breast Cancer Undergoing Axillary Lymph Node Dissection

  NCT03927027

  Conditions:   Breast Cancer Stage I;   Breast Cancer Stage II;   Breast Cancer Stage III
  Interventions:   Drug: Isosulfan Blue;   Procedure: Axillary Lymph Node Dissection;   Procedure: Mapping;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration
  Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI)
  Recruiting
• A Study of Nivolumab +/- Nab-paclitaxel in Non-small Cell Lung Cancer

  NCT02967133

  Conditions:   Non-Small-Cell Lung Cancer Metastatic;   Non-Small Cell Carcinoma of Lung, TNM Stage 4;   Nonsmall Cell Lung Cancer;   Non Small Cell Lung Cancer Recurrent
  Interventions:   Drug: Nivolumab;   Drug: nab-paclitaxel
  Sponsors:   Alliance Foundation Trials, LLC.;   Celgene Corporation;   Bristol-Myers Squibb
  Active, not recruiting
• Phase 1 Study of BXQ-350 in Adult Patients With Advanced Solid Tumors

  NCT02859857

  Condition:   Neoplasms
  Intervention:   Drug: BXQ-350
  Sponsors:   Bexion Pharmaceuticals, Inc.;   CTI Clinical Trial and Consulting Services
  Active, not recruiting
• Efficacy and Safety of Aczone 7.5% Gel in the Treatment of Truncal Acne Vulgaris

  NCT02944461

  Condition:   Acne
  Intervention:   Drug: Dapsone 7.5 % gel
  Sponsor:   Derm Research, PLLC
  Completed
• Onalespib and Paclitaxel in Treating Patients With Advanced Triple Negative Breast Cancer

  NCT02474173

  Conditions:   Estrogen Receptor Negative;   HER2/Neu Negative;   Progesterone Receptor Negative;   Stage III Breast Cancer AJCC v7;   Stage IIIA Breast Cancer AJCC v7;   Stage IIIB Breast Cancer AJCC v7;   Stage IIIC Breast Cancer AJCC v7;   Stage IV Breast Cancer AJCC v6 and v7;   Triple-Negative Breast Carcinoma
  Interventions:   Other: Laboratory Biomarker Analysis;   Drug: Onalespib;   Drug: Paclitaxel;   Other: Pharmacological Study
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Immunotherapy and SBRT Study in Borderline Resectable Pancreatic Cancer

  NCT02405585

  Conditions:   Pancreatic Cancer;   Pancreatic Carcinoma Non-resectable
  Interventions:   Drug: mFOLFIRINOX;   Biological: Algenpantucel-L Immunotherapy;   Radiation: SBRT;   Drug: Gemcitabine
  Sponsor:   NewLink Genetics Corporation
  Terminated
• Study of GBR 1302 (CD3 Bispecific Ab) in HER2-positive Metastatic Breast Cancer

  NCT03983395

  Condition:   Breast Cancer
  Interventions:   Biological: GBR 1302 250 ng/kg;   Biological: GBR 1302 325 ng/kg;   Biological: GBR 1302 325 ng/kg-D1;425 ng/kg -D8,D15,D22;   Biological: GBR 1302 325 ng/kg-D1;550 ng/kg -D8,D15,D22;   Biological: GBR1302 325ng/kgD1;550 ng/kg D8;700 ng/kgD15,22;   Biological: GBR1302 325ng/kg D1;550 ng/kg D8;900 ng/kg D15,22;   Biological: GBR1302 escalating doses,1200 ng/kg D15,22;   Biological: GBR1302 at the MTD and/or RP2D dose
  Sponsor:   Glenmark Pharmaceuticals S.A.
  Not yet recruiting
• Pre-Operative Cemiplimab Administered Intralesionally for Patients With Recurrent Cutaneous Squamous Cell Carcinoma

  NCT03889912

  Condition:   Cutaneous Squamous Cell Carcinoma
  Intervention:   Drug: Cemiplimab
  Sponsors:   Regeneron Pharmaceuticals;   Sanofi
  Recruiting
• Treating Pain With Acceptance and Commitment Therapy Trial

  NCT03666455

  Conditions:   Acceptance and Commitment Therapy;   Chronic Pain;   Opioid Use
  Intervention:   Behavioral: Acceptance and Commitment Therapy
  Sponsors:   University of New Mexico;   University of Kansas Medical Center;   University of North Carolina, Chapel Hill;   University of Kentucky
  Recruiting
• Safety and Tolerability of Conversion From Oral or Injectable Disease Modifying Therapies to Dose-titrated Oral Siponimod in Advancing RMS Patients.

  NCT03623243

  Condition:   Multiple Sclerosis, Relapsing MS, Advancing Multiple Sclerosis
  Intervention:   Drug: Siponimod
  Sponsor:   Novartis Pharmaceuticals
  Recruiting
• Physician Clinical Trial Policy (CTP) Neurological Ischemia Lower Extremity Pain and Swelling

  NCT01979367

  Condition:   Lower Extremity Swelling Acute
  Intervention:   Device: Anodyne
  Sponsor:   American Association of Sensory Electrodiagnostic Medicine
  Enrolling by invitation
• Efficacy and Safety of Enstilar Foam in Combination With Apremilast (Otezla) in Patients With Moderate Plaque Psoriasis

  NCT03441789

  Condition:   Plaque Psoriasis
  Interventions:   Drug: Enstilar;   Drug: Vehicle;   Drug: Otezla
  Sponsor:   L.H. Kircik, M.D.
  Completed
• Lumbar Discectomy Control Study, Risk Factors for Reherniation

  NCT02477176

  Condition:   Lumbar Spine Disc Herniation
  Intervention:   Other: Discectomy
  Sponsor:   Intrinsic Therapeutics
  Active, not recruiting
• DyeVert™ System Use for Contrast Monitoring and Minimization in At-Risk Patients Undergoing Angiography Procedures: A Real-World Registry

  NCT03825094

  Condition:   Patients Undergoing Cardiac Angiography Who Are at Risk for Contrast Induced Acute Kidney Injury
  Intervention:   Device: DyeVert™ Contrast Reduction Systems
  Sponsor:   Osprey Medical, Inc
  Enrolling by invitation
• The PATH Home Trial: A Comparative Effectiveness Study of Peripartum Opioid Use Disorder in Rural Kentucky

  NCT03725332

  Condition:   Neonatal Abstinence Syndrome
  Interventions:   Behavioral: Telemedicine;   Behavioral: Group Care
  Sponsors:   Agatha Critchfield;   Patient-Centered Outcomes Research Institute
  Recruiting