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• Computerized Intervention for Loneliness

  NCT03839966

  Condition:   Loneliness
  Interventions:   Behavioral: Interpretation Bias Modification for Loneliness;   Behavioral: Healthy Habits Psychoeducation and Relaxation
  Sponsor:   Florida State University
  Recruiting
• Building Closer Friendships in Social Anxiety Disorder

  NCT03671577

  Condition:   Social Anxiety
  Intervention:   Behavioral: Building Closer Friendships
  Sponsor:   Florida State University
  Recruiting
• Family Genetics Health Education and Healthy Behaviors

  NCT01498276

  Conditions:   Diabetes;   Cancer;   Heart Disease
  Intervention:  
  Sponsor:   National Human Genome Research Institute (NHGRI)
  Recruiting
• Study of Pegilodecakin (LY3500518) With Pembrolizumab Compared to Pembrolizumab Alone First-line Tx in Participants With Metastatic Non-Small Cell Lung Cancer

  NCT03382899

  Condition:   Non Small Cell Lung Cancer
  Interventions:   Biological: Pegilodecakin;   Drug: Pembrolizumab
  Sponsors:   Eli Lilly and Company;   ARMO BioSciences
  Recruiting
• This Study Tests Whether BI 425809 Together With Brain Training Using a Computer Improves Mental Functioning in Patients With Schizophrenia

  NCT03859973

  Condition:   Schizophrenia
  Interventions:   Drug: BI 425809;   Drug: Placebo
  Sponsor:   Boehringer Ingelheim
  Recruiting
• Clinical Study to Compare the Efficacy and Safety of Ponesimod to Placebo in Subjects With Active Relapsing Multiple Sclerosis Who Are Treated With Dimethyl Fumarate (Tecfidera®)

  NCT02907177

  Condition:   Multiple Sclerosis
  Interventions:   Drug: Ponesimod;   Other: Placebo
  Sponsor:   Actelion
  Recruiting
• Post-Approval 'Real Conditions of Use' Study

  NCT02555280

  Condition:   Spinal Stenosis
  Interventions:   Device: coflex® Interlaminar Technology;   Procedure: Decompression
  Sponsors:   Paradigm Spine;   Musculoskeletal Clinical Regulatory Advisers
  Recruiting
• Evaluation of Lasofoxifene Versus Fulvestrant in Advanced or Metastatic ER+/HER2− Breast Cancer With an ESR1 Mutation

  NCT03781063

  Condition:   Locally Advanced or Metastatic Breast Cancer
  Interventions:   Drug: Lasofoxifene;   Drug: Fulvestrant
  Sponsors:   Sermonix Pharmaceuticals LLC;   Linical Accelovance Group
  Recruiting
• Platform Trial Evaluating Safety and Efficacy of BI 754091 Anti- PD-1 Based Combination Therapies in PD-(L)1 naïve and PD- (L)1 Pretreated Patient Populations With Advanced/Metastatic Solid Tumours.

  NCT03697304

  Condition:   Neoplasm Metastasis
  Interventions:   Drug: BI 754091;   Drug: BI 754111
  Sponsor:   Boehringer Ingelheim
  Recruiting
• A Study to Investigate Atezolizumab and Chemotherapy Compared With Placebo and Chemotherapy in the Neoadjuvant Setting in Participants With Early Stage Triple Negative Breast Cancer

  NCT03197935

  Condition:   Triple-negative Breast Cancer
  Interventions:   Drug: Atezolizumab (MPDL3280A), an engineered anti-PDL1 antibody;   Drug: Placebo;   Drug: Nab-paclitaxel;   Drug: Doxorubicin;   Drug: Cyclophosphamide;   Drug: Filgrastim;   Drug: Pegfilgrastim
  Sponsor:   Hoffmann-La Roche
  Recruiting
• A Study to Assess the Safety, Tolerability and Effectiveness of MT-0814 for the Treatment of Age-related Macular Degeneration

  NCT03869684

  Condition:   Age-related Macular Degeneration
  Interventions:   Drug: MT-0814;   Drug: Placebo
  Sponsors:   Senju Pharmaceutical Co., Ltd.;   PPD
  Recruiting
• A Study Assessing the Safety, Tolerability, and Efficacy of RO7171009 in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration (AMD)

  NCT03972709

  Conditions:   Macular Degeneration, Age-Related;   Geographic Atrophy
  Interventions:   Drug: RO7171009;   Drug: Sham Control
  Sponsor:   Genentech, Inc.
  Recruiting
• Florida Pancreas Collaborative Next Generation Biobank

  NCT03851133

  Conditions:   Pancreatic Cancer;   Cancer Cachexia
  Interventions:   Other: Blood Sample Collection;   Other: Tumor Sample collection;   Other: Data Collection
  Sponsor:   H. Lee Moffitt Cancer Center and Research Institute
  Recruiting
• A Study to Evaluate the Efficacy and Safety of Faricimab in Participants With Neovascular Age-Related Macular Degeneration (LUCERNE)

  NCT03823300

  Condition:   Wet Macular Degeneration
  Interventions:   Drug: Faricimab;   Drug: Aflibercept;   Drug: Sham Procedure
  Sponsor:   Hoffmann-La Roche
  Recruiting
• A Trial to Evaluate Efficacy and Safety of Ribociclib With Endocrine Therapy as Adjuvant Treatment in Patients With HR+/HER2- Early Breast Cancer

  NCT03701334

  Condition:   Early Breast Cancer
  Interventions:   Drug: Ribociclib;   Other: Endocrine Therapy
  Sponsors:   Novartis Pharmaceuticals;   Translational Research in Oncology
  Recruiting
• GB001 in Adult Subjects With Moderate to Severe Asthma

  NCT03683576

  Condition:   Asthma
  Interventions:   Drug: GB001;   Drug: Placebo Oral Tablet
  Sponsor:   GB001, Inc, a wholly owned subsidiary of Gossamer Bio, Inc.
  Recruiting
• Efficacy and Safety Study of Luspatercept (ACE-536) Versus Epoetin Alfa for the Treatment of Anemia Due to IPSS-R Very Low, Low or Intermediate Risk Myelodysplastic Syndromes (MDS) in ESA Naïve Subjects Who Require Red Blood Cell Transfusions

  NCT03682536

  Condition:   Myelodysplastic Syndromes
  Interventions:   Drug: Luspatercept;   Drug: Epoetin alfa
  Sponsors:   Celgene;   Acceleron Pharma, Inc.
  Recruiting
• A Phase III Study to Evaluate the Port Delivery System Implant With Ranibizumab Compared With Monthly Ranibizumab Injections in Participants With Wet Age-Related Macular Degeneration (Archway)

  NCT03677934

  Condition:   Neovascular Age-Related Macular Degeneration
  Interventions:   Drug: PDS Implant filled with 100 mg/mL Ranibizumab;   Drug: Intravitreal Injections of 10 mg/mL Ranibizumab
  Sponsor:   Hoffmann-La Roche
  Recruiting
• Medtronic Transcatheter Aortic Valve Replacement (TAVR) Low Risk Bicuspid Study

  NCT03635424

  Condition:   Bicuspid Aortic Valve
  Intervention:   Device: Medtronic TAVR Systems
  Sponsor:   Medtronic Cardiovascular
  Recruiting
• A Study to Evaluate the Efficacy and Safety of Faricimab (RO6867461) in Participants With Diabetic Macular Edema (YOSEMITE)

  NCT03622580

  Condition:   Diabetic Macular Edema
  Interventions:   Drug: Aflibercept;   Drug: Faricimab;   Drug: Sham Procedure
  Sponsor:   Hoffmann-La Roche
  Recruiting
• Effect of Sotagliflozin on Cardiovascular Events in Patients With Type 2 Diabetes Post Worsening Heart Failure (SOLOIST-WHF Trial)

  NCT03521934

  Condition:   Heart Failure-Type 2 Diabetes Mellitus
  Interventions:   Drug: Sotagliflozin (SAR439954);   Drug: Placebo
  Sponsor:   Sanofi
  Recruiting
• Brief Title: Study of Efficacy and Safety of Canakinumab as Adjuvant Therapy in Adult Subjects With Stages AJCC/UICC v. 8 II-IIIA and IIIB (T>5cm N2) Completely Resected Non-small Cell Lung Cancer Acronym: CANOPY-A

  NCT03447769

  Condition:   Non-Small Cell Lung Cancer
  Interventions:   Drug: Canakinumab;   Drug: Placebo
  Sponsor:   Novartis Pharmaceuticals
  Recruiting
• Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation

  NCT03433274

  Conditions:   Mitral Regurgitation;   Mitral Insufficiency;   Mitral Valve Insufficiency;   Cardiovascular Diseases;   Valve Disease, Heart;   Heart Valve Diseases;   Functional Mitral Regurgitation;   Degenerative Mitral Valve Disease
  Interventions:   Device: Tendyne Mitral Valve System;   Device: MitraClip System
  Sponsor:   Tendyne Holdings, Inc.
  Recruiting
• Observational Study of Characteristics, Treatment and Outcomes With Severe Asthma in the United States (CHRONICLE)

  NCT03373045

  Condition:   Asthma
  Intervention:  
  Sponsors:   AstraZeneca;   Parexel;   MedImmune LLC
  Recruiting
• Corticosteroid Lumbar Epidural Analgesia for Radiculopathy

  NCT03372161

  Condition:   Lumbosacral Radicular Pain
  Interventions:   Drug: SP-102;   Drug: Placebo
  Sponsors:   Semnur Pharmaceuticals, Inc.;   Worldwide Clinical Trials
  Recruiting
• A Study of ABT-165 Plus FOLFIRI vs Bevacizumab Plus FOLFIRI in Subjects With Metastatic Colorectal Cancer Previously Treated With Fluoropyrimidine, Oxaliplatin and Bevacizumab

  NCT03368859

  Condition:   Cancer
  Interventions:   Drug: Leucovorin;   Drug: Fluorouracil - bolus;   Drug: Bevacizumab;   Drug: Fluorouracil - infusion;   Drug: ABT-165;   Drug: Irinotecan
  Sponsor:   AbbVie
  Recruiting
• Tesetaxel Plus Reduced Dose of Capecitabine vs. Capecitabine in HER2 Negative, HR Positive, LA/MBC

  NCT03326674

  Condition:   Breast Cancer
  Interventions:   Drug: Tesetaxel and Capecitabine;   Drug: Capecitabine
  Sponsor:   Odonate Therapeutics, Inc.
  Recruiting
• Strategic Management to Improve CRT Using Multi-Site Pacing Post Approval Study (Reference # C1918)

  NCT03257436

  Condition:   Left Ventricular Dysfunction
  Intervention:   Device: CRT-D
  Sponsors:   Boston Scientific Corporation;   ICON Clinical Research
  Recruiting
• Maintenance Chemotherapy With or Without Local Consolidative Therapy in Treating Patients With Stage IV Non-small Cell Lung Cancer

  NCT03137771

  Conditions:   Recurrent Non-Small Cell Lung Carcinoma;   Stage IV Non-Small Cell Lung Cancer
  Interventions:   Radiation: 3-Dimensional Conformal Radiation Therapy (3D-CRT);   Drug: Docetaxel;   Drug: Gemcitabine;   Radiation: Intensity-Modulated Radiation Therapy (IMRT);   Drug: Pemetrexed Disodium;   Radiation: Stereotactic Body Radiation Therapy (SBRT);   Drug: Erlotinib Hydrochloride;   Drug: Pembrolizumab
  Sponsors:   NRG Oncology;   National Cancer Institute (NCI)
  Recruiting
• Pilot Study to Assess the Efficacy & Safety of H.P. Acthar® Gel in Subjects With Relapsing-remitting Multiple Sclerosis

  NCT03126760

  Condition:   Relapsing, Remitting Multiple Sclerosis
  Interventions:   Drug: Repository Corticotropin Injection;   Drug: Placebo
  Sponsor:   Mallinckrodt
  Recruiting
• Evaluation of Treatment Strategies for Severe CaLcIfic Coronary Arteries: Orbital Atherectomy vs. Conventional Angioplasty Technique Prior to Implantation of Drug-Eluting StEnts: The ECLIPSE Trial

  NCT03108456

  Conditions:   Coronary Artery Disease;   Ischemic Heart Disease;   Non ST Segment Elevation Myocardial Infarction
  Interventions:   Device: Orbital Atherectomy;   Device: Balloon
  Sponsors:   Cardiovascular Systems Inc;   Cardiovascular Research Foundation, New York
  Recruiting
• REDUCE LAP-HF TRIAL II

  NCT03088033

  Condition:   Heart Failure
  Interventions:   Device: IASD System II implant;   Other: intra-cardiac echocardiography (ICE), or transesophageal echocardiography (TEE)
  Sponsor:   Corvia Medical
  Recruiting
• Pemafibrate to Reduce Cardiovascular OutcoMes by Reducing Triglycerides IN patiENts With diabeTes (PROMINENT)

  NCT03071692

  Conditions:   Type2 Diabetes;   Dyslipidemia
  Interventions:   Drug: K-877;   Drug: Placebo
  Sponsors:   Kowa Research Institute, Inc.;   Brigham and Women's Hospital
  Recruiting
• RESOLUTE ONYX Post-Approval Study

  NCT03063749

  Condition:   Coronary Artery Disease
  Intervention:   Device: Resolute Onyx™ Zotarolimus-Eluting Coronary Stent System
  Sponsor:   Medtronic Vascular
  Recruiting
• Pembrolizumab in Treating Patients With Triple-Negative Breast Cancer

  NCT02954874

  Conditions:   Estrogen Receptor Negative;   HER2/Neu Negative;   Invasive Breast Carcinoma;   Progesterone Receptor Negative;   Stage 0 Breast Cancer AJCC v6 and v7;   Stage I Breast Cancer AJCC v7;   Stage IA Breast Cancer AJCC v7;   Stage IB Breast Cancer AJCC v7;   Stage II Breast Cancer AJCC v6 and v7;   Stage IIA Breast Cancer AJCC v6 and v7;   Stage IIB Breast Cancer AJCC v6 and v7;   Stage III Breast Cancer AJCC v7;   Stage IIIA Breast Cancer AJCC v7;   Stage IIIB Breast Cancer AJCC v7;   Stage IIIC Breast Cancer AJCC v7;   Triple-Negative Breast Carcinoma
  Interventions:   Other: Laboratory Biomarker Analysis;   Other: Patient Observation;   Biological: Pembrolizumab;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration;   Radiation: Radiation Therapy
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Study of Ibrutinib and Rituximab in Treatment Naïve Follicular Lymphoma

  NCT02947347

  Condition:   Treatment Naive Follicular Lymphoma
  Interventions:   Drug: ibrutinib;   Drug: placebo to match ibrutinib;   Drug: rituximab
  Sponsor:   Pharmacyclics LLC.
  Recruiting
• Edoxaban Compared to Standard Care After Heart Valve Replacement Using a Catheter in Patients With Atrial Fibrillation (ENVISAGE-TAVI AF)

  NCT02943785

  Condition:   Atrial Fibrillation
  Interventions:   Drug: Edoxaban-based Regimen;   Drug: VKA-based Regimen
  Sponsors:   Daiichi Sankyo, Inc.;   Chiltern International Inc.
  Recruiting
• Assessment of Primary Prevention Patients Receiving An ICD - Systematic Evaluation of ATP

  NCT02923726

  Condition:   Sudden Cardiac Death
  Interventions:   Device: Arm 1 (ATP+Shock);   Device: Arm 2 (shock only)
  Sponsors:   Boston Scientific Corporation;   ICON plc
  Recruiting
• Shockwave Medical Peripheral Lithoplasty System Study for PAD (Disrupt PAD III)

  NCT02923193

  Condition:   Peripheral Arterial Disease
  Interventions:   Device: Shockwave Lithoplasty® Peripheral Lithoplasty System;   Drug: Medtronic IN.PACT (DCB)
  Sponsor:   Shockwave Medical, Inc.
  Recruiting
• Memory Gel and Shape Combined Cohort

  NCT02919592

  Conditions:   Primary Breast Augmentation;   Primary Breast Reconstruction;   Revision Breast Augmentation;   Revision Breast Reconstruction
  Interventions:   Device: MemoryShape® Breast Implants;   Device: MemoryGel® Breast Implants;   Procedure: Other Aesthetic Surgery
  Sponsor:   Mentor Worldwide, LLC
  Recruiting
• Study to Assess the Efficacy and Safety of Ublituximab + TGR-1202 With or Without Bendamustine and TGR-1202 Alone in Patients With Previously Treated Non-Hodgkins Lymphoma

  NCT02793583

  Conditions:   Diffuse Large B-Cell Lymphoma;   Follicular Lymphoma;   Marginal Zone Lymphoma;   Mantle Cell Lymphoma
  Interventions:   Drug: TGR-1202 + Ublituximab;   Drug: TGR-1202;   Drug: TGR-1202 + Ublituximab + Bendamustine
  Sponsor:   TG Therapeutics, Inc.
  Recruiting
• Breast Cancer WEight Loss Study (BWEL Study)

  NCT02750826

  Condition:   Breast Carcinoma
  Interventions:   Other: Health Education Program;   Other: Weight Loss Intervention
  Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI);   Division of Cancer Control;   NIH Biomarker, Imaging and Quality of Life Studies Funding Program (BIQSFP);   Canadian Cancer Trials Group
  Recruiting
• Doxorubicin Hydrochloride and Cyclophosphamide Followed by Paclitaxel With or Without Carboplatin in Treating Patients With Triple-Negative Breast Cancer

  NCT02488967

  Conditions:   Breast Adenocarcinoma;   Estrogen Receptor Negative;   HER2/Neu Negative;   Progesterone Receptor Negative;   Stage IB Breast Cancer;   Stage IIA Breast Cancer;   Stage IIB Breast Cancer;   Stage IIIA Breast Cancer;   Stage IIIC Breast Cancer;   Triple-Negative Breast Carcinoma
  Interventions:   Drug: Carboplatin;   Drug: Cyclophosphamide;   Drug: Doxorubicin Hydrochloride;   Other: Laboratory Biomarker Analysis;   Drug: Paclitaxel
  Sponsors:   NRG Oncology;   National Cancer Institute (NCI)
  Recruiting
• SPYRAL HTN-ON MED Study

  NCT02439775

  Conditions:   Hypertension;   Vascular Diseases;   Cardiovascular Diseases
  Interventions:   Device: Symplicity Spyral™ multi-electrode renal denervation system;   Procedure: Sham Procedure
  Sponsor:   Medtronic Vascular
  Recruiting
• SPYRAL PIVOTAL - SPYRAL HTN-OFF MED Study

  NCT02439749

  Conditions:   Hypertension;   Vascular Diseases;   Cardiovascular Diseases
  Interventions:   Device: Symplicity Spyral™ multi-electrode renal denervation system;   Procedure: Sham Procedure
  Sponsor:   Medtronic Vascular
  Recruiting
• Web Based Orthopaedic Sports Medicine Registry

  NCT01191151

  Conditions:   Degenerative and Traumatic Pathology of the Knee;   Degenerative and Traumatic Pathology of the Shoulder and Elbow;   Degenerative and Traumatic Pathology of the Foot and Ankle;   Degenerative and Traumatic Pathology of the Hand and Wrist;   Degenerative and Traumatic Pathology of the Hip
  Intervention:  
  Sponsor:   Arthrex, Inc.
  Recruiting
• A Long-Term Registry of Humira® (Adalimumab) in Patients With Moderately to Severely Active Ulcerative Colitis (UC)

  NCT01848561

  Condition:   Ulcerative Colitis (UC)
  Intervention:  
  Sponsor:   AbbVie
  Recruiting
• Connect® MDS/AML Disease Registry

  NCT01688011

  Conditions:   Myelodysplastic Syndromes;   Acute Myeloid Leukemia
  Intervention:  
  Sponsor:   Celgene
  Recruiting
• A Phase III Study of Efficacy and Safety of Ligelizumab in the Treatment of CSU in Adolescents and Adults Inadequately Controlled With H1-antihistamines

  NCT03580369

  Condition:   Chronic Spontaneous Urticaria
  Interventions:   Biological: Ligelizumab;   Biological: Omalizumab;   Other: Placebo
  Sponsor:   Novartis Pharmaceuticals
  Recruiting
• Medtronic Evolut Transcatheter Aortic Valve Replacement in Low Risk Patients

  NCT02701283

  Condition:   Aortic Valve Stenosis
  Interventions:   Device: Medtronic Transcatheter Aortic Valve Replacement Systems;   Device: Surgical Aortic Valve Replacement (SAVR)
  Sponsor:   Medtronic Cardiovascular
  Recruiting
• A Multicenter Randomized 52 Week Treatment Double-blind, Triple Dummy Parallel Group Study to Assess the Efficacy and Safety of QMF149 Compared to Mometasone Furoate in Patients With Asthma

  NCT02554786

  Condition:   Asthma
  Interventions:   Drug: QMF149;   Drug: MF 400;   Drug: salmeterol /fluticasone
  Sponsor:   Novartis Pharmaceuticals
  Recruiting