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• The Effect of Lactation on Insulin Sensitivity and Lipolysis in Women

  NCT04146909

  Conditions:   GDM;   Lactation
  Intervention:   Diagnostic Test: Hyperinsulinemic-euglycemic clamp
  Sponsors:   Yale University;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
  Recruiting
• A Study To Determine The Safety, Tolerability, Skin Irritation Potential, And PK Following Topical Application Of PF-07038124 In Healthy Participants

  NCT04135560

  Condition:   Dermatitis Atopic
  Interventions:   Drug: PF-07038124 and Vehicle;   Drug: PF-07038124 or vehicle
  Sponsor:   Pfizer
  Recruiting
• Perinatal Attentional Retraining Intervention for Smoking for Minority Women

  NCT04114877

  Condition:   Postpartum Smoking Relapse
  Interventions:   Behavioral: Attentional retraining (AR);   Behavioral: Visual probe (VP)
  Sponsors:   Yale University;   National Institute on Minority Health and Health Disparities (NIMHD)
  Recruiting
• A Study to Demonstrate the Equivalence of the Tofacitinib Oral Solution to the Tablet Formulation in Healthy Participants.

  NCT04111614

  Condition:   Healthy
  Interventions:   Drug: Tofacitinib tablet;   Drug: Tofacitinib Oral Solution
  Sponsor:   Pfizer
  Recruiting
• A Study to Investigate the Effect of Multiple Doses of Itraconazole on the Pharmacokinetics of PF-06700841 in Healthy Participants

  NCT04090047

  Condition:   Heathy Participants
  Interventions:   Drug: PF-06700841;   Drug: Itraconazole
  Sponsor:   Pfizer
  Recruiting
• Study of Commercial and Phase 3 of PF-04965842 Formulations, Estimation of Effect of Food on Commercial Formulation

  NCT04065633

  Condition:   Dermatitis, Atopic
  Interventions:   Drug: P3-Fast;   Drug: Comm-Fast;   Drug: Vari-Fast;   Drug: Comm-Fed
  Sponsor:   Pfizer
  Recruiting
• Guanfacine to Improve Substance Use Outcomes in Women

  NCT03980184

  Condition:   Substance Use Disorders
  Interventions:   Drug: Guanfacine;   Other: placebo
  Sponsor:   Yale University
  Recruiting
• Cognitive-Behavioral and Pharmacologic (LDX) Treatment of Binge-Eating Disorder and Obesity: Medication Change for Non-Responders

  NCT03946111

  Conditions:   Binge-Eating Disorder;   Obesity
  Interventions:   Drug: Naltrexone and Bupropion;   Other: Placebo
  Sponsor:   Yale University
  Recruiting
• Transcranial Direct Current Stimulation and Fear Extinction

  NCT03907917

  Condition:   Anxiety Disorders
  Intervention:   Device: tDCS
  Sponsors:   Yale University;   National Institute of Mental Health (NIMH)
  Recruiting
• Neuroimmune Effects of Opioid Administration

  NCT03801629

  Conditions:   Microgliosis;   Drug Effect
  Intervention:   Drug: Intramuscular Morphine
  Sponsor:   Yale University
  Recruiting
• The Effects of MDMA on Prefrontal and Amygdala Activation in PTSD.

  NCT03752918

  Condition:   Post Traumatic Stress Disorder
  Interventions:   Drug: MDMA;   Drug: Niacin
  Sponsor:   Yale University
  Recruiting
• Influence of Medication on Functional Connectivity

  NCT03612713

  Condition:   Prescription Drug Abuse (Not Dependent)
  Interventions:   Drug: Oxycodone Medication First;   Drug: Placebo First
  Sponsors:   Yale University;   National Institute on Drug Abuse (NIDA)
  Recruiting
• Evaluation of [18F]MNI-1126 as an Imaging Marker for Synaptic Density Loss

  NCT03587649

  Conditions:   Alzheimer Disease;   Parkinson Disease;   Healthy Volunteers
  Intervention:   Drug: [18F]MNI-1126
  Sponsor:   Invicro
  Recruiting
• CB1R in Synthetic Psychoactive Cannabinoids

  NCT03539575

  Condition:   Drug Dependence
  Intervention:   Other: [11-C]OMAR
  Sponsors:   Yale University;   National Institutes of Health (NIH);   National Institute on Drug Abuse (NIDA)
  Recruiting
• Imaging Synaptic Density in Cocaine and Opiate Addiction In Vivo Using 11UCB-J PET

  NCT03527485

  Conditions:   Opiate Dependence;   Cocaine Dependence
  Intervention:   Diagnostic Test: 11UCB-J PET Scan
  Sponsor:   Yale University
  Recruiting
• Effect of Liraglutide on Neural Responses to High Fructose Corn Syrup in Individuals With Obesity.

  NCT03500484

  Conditions:   Obesity, Childhood;   Neural Development
  Intervention:   Drug: Liraglutide
  Sponsor:   Yale University
  Recruiting
• Efficacy of Psilocybin in OCD: a Double-Blind, Placebo-Controlled Study.

  NCT03356483

  Condition:   Obsessive-Compulsive Disorder
  Interventions:   Drug: Psilocybin (0.25mg/kg);   Drug: Niacin (250mg)
  Sponsors:   Yale University;   Heffter Research Institute
  Recruiting
• Mavoglurant in Alcohol Drinking

  NCT03327792

  Condition:   Alcohol Drinking
  Interventions:   Drug: Mavoglurant;   Drug: Placebo
  Sponsor:   Yale University
  Recruiting
• The Neural Correlates of Cannabis Use

  NCT03104257

  Conditions:   Cannabis Dependence;   Healthy
  Intervention:   Other: [11-C]OMAR
  Sponsors:   Yale University;   National Institute on Drug Abuse (NIDA)
  Recruiting
• Vitamin D as a Therapeutic Adjunct in the Stimulant Treatment of ADHD

  NCT03103750

  Condition:   ADHD
  Interventions:   Procedure: Magnetic Resonance Imaging (MRI);   Drug: Raclopride;   Dietary Supplement: calcitriol;   Drug: Placebo oral capsule;   Procedure: high-resolution research tomography;   Drug: Dextro Amphetamine
  Sponsors:   Yale University;   Brain & Behavior Research Foundation
  Recruiting
• Glutamate-Glutamine Cycling (VCYC) During Cocaine Abstinence Using 1H-MRS

  NCT02124941

  Conditions:   Cocaine Dependence;   Healthy
  Interventions:   Drug: N-acetyl cysteine;   Diagnostic Test: [18F]FDG PET scan;   Diagnostic Test: 1H MRS;   Diagnostic Test: [11C]APP311 PET scan
  Sponsor:   Yale University
  Recruiting
• Ketamine in Borderline Personality Disorder

  NCT03395314

  Condition:   Borderline Personality Disorder
  Interventions:   Drug: Ketamine;   Drug: Midazolam
  Sponsors:   Yale University;   Nathan Kline Institute for Psychiatric Research;   American Foundation for Suicide Prevention
  Recruiting
• Imaging Cannabinoid Receptors Using Positron Emission Tomography (PET) Scanning

  NCT01730781

  Conditions:   Schizophrenia;   Cannabis Dependence;   Prodromal for Psychotic Illness;   Family History of Alcoholism;   Healthy Control
  Intervention:   Radiation: [11-C]OMAR
  Sponsors:   Yale University;   National Institute on Drug Abuse (NIDA);   National Institute of Mental Health (NIMH)
  Recruiting
• Imaging the Neurochemistry of Drug Addiction With PET

  NCT02817698

  Conditions:   Smoking;   Cannabis
  Intervention:   Drug: cannabis
  Sponsor:   Yale University
  Recruiting
• Acetylcholine, Tobacco Smoking, Genes and Nicotinic Receptors

  NCT02008292

  Conditions:   Smoking;   Schizophrenia
  Intervention:   Drug: Physostigmine
  Sponsors:   Yale University;   National Institutes of Health (NIH);   National Institute on Drug Abuse (NIDA)
  Recruiting
• Evaluating the Feasibility and Efficacy of a Real-time Smoking Intervention Using Wearable Technology

  NCT04172623

  Condition:   Tobacco Use Cessation
  Interventions:   Behavioral: Real-Time Smoking Intervention;   Behavioral: Standard Treatment
  Sponsors:   Yale University;   Patterson Trust Mentored Research Award: Clinical, Health Services and Policy Research
  Recruiting
• Examining the Effect of Burosumab on Muscle Function

  NCT04146935

  Condition:   X-linked Hypophosphatemia
  Intervention:   Drug: Burosumab Injection [Crysvita]
  Sponsor:   Yale University
  Recruiting
• Evaluation of [18F]APN-1607 PET Uptake in Alzheimer's Disease Patients Compared With Healthy Subjects

  NCT04141150

  Conditions:   Alzheimer's Disease;   Mild Cognitive Impairment Due to Alzheimer's Disease;   Healthy Volunteers
  Intervention:   Drug: [18F]APN-1607
  Sponsor:   Aprinoia Therapeutics Inc.
  Recruiting
• Brain Network Changes Accompanying and Predicting Responses to Pharmacotherapy in OCD

  NCT04131829

  Condition:   Obsessive-Compulsive Disorder
  Interventions:   Drug: Fluoxetine - immediate treatment;   Drug: Fluoxetine - delayed treatment
  Sponsors:   Yale University;   National Institute of Mental Health (NIMH)
  Recruiting
• The Recovery in Stroke Using PAP Study

  NCT04130503

  Conditions:   Ischemic Stroke;   Obstructive Sleep Apnea
  Interventions:   Device: PAP;   Behavioral: HLE
  Sponsors:   Yale University;   Hartford HealthCare
  Recruiting
• Peripheral Benzodiazepine Receptors (PBR28) Brain PET Imaging With Lipopolysaccharide Challenge for the Study of Microglia Function in Alzheimer's Disease

  NCT04057807

  Condition:   Alzheimer Disease
  Intervention:   Drug: LPS
  Sponsor:   Yale University
  Recruiting
• Hepatitis C Positive Organ to Recipient Hepatitis C Negative Longitudinal Transplant Study

  NCT04057001

  Conditions:   Liver Transplant; Complications;   Hepatitis C
  Intervention:  
  Sponsor:   Yale University
  Recruiting
• GLAD-AML - Glasdegib (Pf-04449913) With Two Standard Decitabine Regimens for Older Patients With Poor-risk Acute Myeloid Leukemia

  NCT04051996

  Condition:   ACUTE MYELOID LEUKEMIA
  Interventions:   Drug: Glasdegib;   Drug: Decitabine
  Sponsors:   Yale University;   Pfizer Inc., U.S. Pharmaceuticals Group
  Recruiting
• Detection of Postoperative Respiratory Depression in High Risk Patients Utilizing Minute Ventilation Monitoring

  NCT04017702

  Condition:   Respiratory Depression
  Intervention:   Device: Expiron respirator
  Sponsor:   Yale University
  Recruiting
• Impact of Cigarette and E-cigarette Flavors on Adult Smoking Behavior

  NCT04009850

  Condition:   Tobacco Use
  Interventions:   Other: Cigarette Brand Switching;   Other: E-cigarette Flavor
  Sponsors:   Yale University;   National Institute on Drug Abuse (NIDA);   Food and Drug Administration (FDA)
  Recruiting
• SV2 PET Imaging With [11C]APP311

  NCT03995121

  Conditions:   Schizophrenia and Other Psychotic Disorders;   Cannabis Use Disorder;   Healthy
  Intervention:   Radiation: [11C]APP311
  Sponsor:   Yale University
  Recruiting
• Ivabradine for Rate Control in Permanent Atrial Fibrillation

  NCT03987204

  Conditions:   Atrial Fibrillation;   Atrial Fibrillation, Persistent
  Intervention:   Drug: Ivabradine
  Sponsor:   Yale University
  Recruiting
• Dronabinol for Pain and Inflammation in Adults Living With Sickle Cell Disease

  NCT03978156

  Condition:   Sickle Cell Disease
  Interventions:   Drug: Dronabinol;   Drug: Placebo oral tablet
  Sponsor:   Yale University
  Recruiting
• Periarticular Injection Versus Peripheral Nerve Block in Total Hip Arthroplasty

  NCT03977454

  Condition:   Hip Arthropathy
  Interventions:   Procedure: Nerve Block;   Procedure: Periarticular Injection (PAI);   Drug: Ropivacaine;   Drug: Dex
  Sponsor:   Yale University
  Recruiting
• A Study of the Effects of LY3372689 on the Brain in Healthy Participants

  NCT03944031

  Condition:   Healthy
  Interventions:   Drug: LY3372689;   Diagnostic Test: [18F]LSN3316612
  Sponsor:   Eli Lilly and Company
  Recruiting
• Objective Evaluation of Paclitaxel/Docetaxel-induced Neuropathy in Breast Cancer Patients

  NCT03872141

  Conditions:   Breast Cancer;   Chemotherapy Induced Peripheral Neuropathy;   Paclitaxel Induced Neuropathy
  Intervention:   Diagnostic Test: Quantitative measures of reduction in Chemotherapy Induced Neuropathy (CIPN) and Cognitive Impairment (CICI) in patients with stage I-III breast cancer
  Sponsor:   Yale University
  Recruiting
• Risk EValuation And Its Impact on ClinicAL Decision Making and Outcomes in Heart Failure

  NCT03845660

  Condition:   Heart Failure
  Intervention:   Behavioral: Electronic Alert
  Sponsor:   Yale University
  Recruiting
• Creation of a Digital Heart Failure Registry Using a Novel Mobile Health Platform: HUGO-HF

  NCT03810638

  Condition:   Heart Failure
  Intervention:  
  Sponsor:   Yale University
  Recruiting
• The EXPLORE MG Registry for Myasthenia Gravis

  NCT03792659

  Condition:   Myasthenia Gravis
  Intervention:   Other: Blood Sample Draw
  Sponsor:   Yale University
  Recruiting
• Mechanistic Evaluation of Guanfacine on Drinking Behavior in Women and Men With Alcohol Use Disorders

  NCT03764098

  Condition:   Alcohol Use
  Interventions:   Drug: Guanfacine ER;   Other: Placebo
  Sponsors:   Yale University;   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
  Recruiting
• Stress Reduction Study for Partners of Early Stage Dementia

  NCT03691428

  Condition:   Dementia Caregiving
  Intervention:   Behavioral: Wish Outcome Obstacle Plan
  Sponsors:   Yale University;   National Institute on Aging (NIA)
  Recruiting
• Daytime Bright Light, Circadian Abnormalities, and Delirium in Medical ICU Patients

  NCT03684460

  Condition:   Circadian Rhythm Disorders
  Interventions:   Device: Daytime Bright Light;   Device: Usual Light
  Sponsor:   Yale University
  Recruiting
• Mindfulness - Based Intervention in the Treatment of Fatigue in Patients With Primary Biliary Cholangitis

  NCT03684187

  Condition:   Primary Biliary Cholangitis
  Intervention:   Behavioral: Mindfulness Based Intervention
  Sponsor:   Yale University
  Recruiting
• Effect of Mental Imagery Training on Brain Plasticity and Motor Function in Individuals With Parkinson's Disease

  NCT03623386

  Condition:   Parkinson Disease
  Interventions:   Other: PD neurofeedback;   Other: PD control
  Sponsor:   Yale University
  Recruiting
• Does Propranolol, a Beta Blocker, Attenuate Stress-Induced Drinking?

  NCT03588754

  Condition:   Alcohol Drinking
  Interventions:   Drug: Propranolol;   Drug: Placebo
  Sponsors:   Yale University;   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
  Recruiting
• The Safety of Thoracentesis, Tunneled Pleural Catheter, and Chest Tubes in Patients Taking Novel Oral Anti-Coagulants

  NCT03535883

  Conditions:   Pleural Effusion;   Thoracic Effusion
  Intervention:   Drug: Novel Oral Anti-Coagulants
  Sponsor:   Yale University
  Recruiting
• APX005M With Nivolumab and Cabiralizumab in Advanced Melanoma, Non-small Cell Lung Cancer or Renal Cell Carcinoma

  NCT03502330

  Conditions:   Advanced Melanoma;   Non-small Cell Lung Cancer;   Renal Cell Carcinoma
  Interventions:   Drug: APX005M;   Drug: Cabiralizumab;   Drug: Nivolumab
  Sponsors:   Yale University;   Bristol-Myers Squibb;   Apexigen, Inc.
  Recruiting
• CBT4CBT With Spanish Alcohol Users

  NCT03474588

  Condition:   Alcohol Use Disorder
  Interventions:   Behavioral: Standard treatment (ST) PLUS web-based CBT4CBT;   Behavioral: Standard Treatment (ST)
  Sponsors:   Yale University;   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
  Recruiting
• Mechanism and Effects of Manipulating Chloride Homeostasis in Acute Heart Failure

  NCT03446651

  Condition:   Heart Failure
  Interventions:   Drug: Lysine Chloride;   Other: Placebo
  Sponsor:   Yale University
  Recruiting
• Assessment of Cognitive Function Before and After Conversion From Immediate Release Tacrolimus to Envarsus XR.

  NCT03410654

  Condition:   Kidney Transplant; Complications
  Intervention:   Drug: Tacrolimus, Extended Release, (Envarsus Xr)
  Sponsor:   Yale University
  Recruiting
• Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response

  NCT03367533

  Condition:   Depressive Disorder, Major
  Interventions:   Drug: Ketamine;   Drug: Perampanel;   Drug: Placebo
  Sponsor:   Yale University
  Recruiting
• An Efficacy Trial of Low Dose All-trans Retinoic Acid in Patients With Primary Sclerosing Cholangitis

  NCT03359174

  Condition:   Cholangitis, Sclerosing
  Intervention:   Drug: All-trans retinoic acid
  Sponsor:   Yale University
  Recruiting
• Lifestyle, Exercise, and Nutrition Study Early After Diagnosis

  NCT03314688

  Condition:   Breast Neoplasms
  Interventions:   Behavioral: Dietary/Physical Activity intervention;   Behavioral: Usual Care
  Sponsor:   Yale University
  Recruiting
• Patient Driven Recovery With Nalmefene and Coaching

  NCT03279562

  Conditions:   Opioid-use Disorder;   Harmful; Use, Alcohol
  Intervention:   Drug: Nalmefene
  Sponsors:   Yale University;   First Pavlov State Medical University in St. Petersburg, Russia
  Recruiting
• Pregnancy, Mindfulness, and Massage

  NCT03276208

  Conditions:   Tobacco Use;   Pregnancy Related
  Interventions:   Other: Prenatal Massage;   Other: Mindfulness
  Sponsors:   Yale University;   Massage Therapy Foundation
  Recruiting
• Toradol to Reduce Ureteroscopic Symptoms Trial

  NCT03111381

  Conditions:   Urinary Lithiasis;   Kidney Diseases;   Kidney Stone;   Pain, Postoperative
  Intervention:   Drug: Toradol
  Sponsor:   Yale University
  Recruiting
• Phase 1 Evaluation of [18F]MK-6240 PET as an Imaging Marker for Tau Protein

  NCT03071224

  Conditions:   Alzheimer Disease;   Healthy Volunteers
  Interventions:   Drug: [18F] MNI-946;   Drug: [18F]Florbetapir
  Sponsor:   Invicro
  Recruiting
• Dual Inhibition of EGFR With Afatinib and Cetuximab in the Treatment of Advanced Squamous Cell Cancers of the Head and Neck

  NCT02979977

  Condition:   Squamous Cell Cancers of the Head and Neck
  Interventions:   Drug: cetuximab;   Drug: afatinib
  Sponsors:   Yale University;   National Comprehensive Cancer Network;   Boehringer Ingelheim
  Recruiting
• Oxytocin and Brain Responses in Maternal Addiction

  NCT02979093

  Condition:   Maternal Behavior
  Interventions:   Drug: Oxytocin;   Drug: Placebos
  Sponsors:   Lane Strathearn, MBBS PhD;   Yale University
  Recruiting
• Pembrolizumab in Ultramutated and Hypermutated Endometrial Cancer

  NCT02899793

  Condition:   Recurrent Endometrial Cancer
  Intervention:   Drug: Pembrolizumab
  Sponsors:   Yale University;   Merck Sharp & Dohme Corp.
  Recruiting
• Treatment of High-Grade Pre-Neoplastic Cervical Lesions (CIN 2/3)

  NCT02864147

  Conditions:   Cervical Intraepithelial Neoplasia;   Cervical Dysplasia
  Interventions:   Drug: 9-valent HPV vaccine;   Drug: Imiquimod
  Sponsor:   Yale University
  Recruiting
• Pilot: Feasibility of Intermittent Enteral Feeding in Ventilated MICU Patients

  NCT04164108

  Condition:   Nutrition
  Intervention:   Dietary Supplement: Intermittent Enteral Nutrition Protocol
  Sponsor:   Yale University
  Recruiting
• Pathogenesis of the Cardiometabolic Risk in Youth With Type 1 Diabetes

  NCT04101045

  Conditions:   Type 1 Diabetes;   De Novo Lipogenesis
  Intervention:   Diagnostic Test: Oral Glucose Tolerance Test
  Sponsors:   Yale University;   Juvenile Diabetes Research Foundation
  Recruiting
• Active Surveillance of the Small Renal Mass

  NCT02204800

  Condition:   Small Renal Mass, Kidney Cancer
  Intervention:  
  Sponsor:   Yale University
  Recruiting
• Window Trial 5-aza in HNSCC, T-tare

  NCT02178072

  Condition:   Head and Neck Squamous Cell Carcinoma
  Intervention:   Drug: 5-Azacitadine
  Sponsor:   Yale University
  Recruiting
• Mechanisms of Obesity and Its Metabolic Complications in Youth

  NCT03454828

  Condition:   Obesity, Childhood
  Interventions:   Dietary Supplement: obese carbohydrate diet;   Dietary Supplement: lean carbohydrate diet
  Sponsor:   Yale University
  Recruiting
• Brain Emotion Circuitry-Targeted Self-Monitoring and Regulation Therapy (BE-SMART)

  NCT03183388

  Condition:   Mood Disorders
  Intervention:   Behavioral: BE-SMART
  Sponsors:   Yale University;   National Institute of Mental Health (NIMH)
  Recruiting
• Blood Glucose Variability and Insulin Action During Menstrual Cycle in Females With Type 1 Diabetes

  NCT02693938

  Condition:   Type 1 Diabetes
  Interventions:   Device: Follicular Euglycemic clamp;   Device: Luteal Euglycemic clamp
  Sponsors:   Yale University;   The Leona M. and Harry B. Helmsley Charitable Trust
  Recruiting
• Comparison Between Gastric Band, Laparoscopic Sleeve Gastrectomy, Gastric Bypass Surgeries

  NCT02004561

  Condition:   Obese Adolescents
  Intervention:  
  Sponsor:   Yale University
  Recruiting
• Hepatic De Novo Lipogenesis (DNL)in the Pathogenesis of Hepatic Steatosis in Obese Youth

  NCT01725035

  Conditions:   Hepatic Steatosis;   Fatty Liver
  Intervention:  
  Sponsors:   Yale University;   American Heart Association;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
  Recruiting
• Evaluation of Weekly Ixabepilone With or Without Biweekly Bevacizumab

  NCT03093155

  Conditions:   Epithelial Ovarian Cancer;   Fallopian Tube Cancer;   Primary Peritoneal Cancer
  Interventions:   Drug: Ixabepilone;   Drug: Bevacizumab
  Sponsors:   Yale University;   R-Pharm-US, LLC
  Recruiting
• Gain-framed Messages and NRT for Lung Cancer Screening Patients

  NCT03069924

  Conditions:   Lung Cancer Screening;   Smoking Cessation
  Interventions:   Behavioral: Gain-framed messaging;   Drug: Nicotine replacement therapy;   Combination Product: Gain-framed messaging plus NRT;   Behavioral: Counseling alone
  Sponsors:   Medical University of South Carolina;   National Cancer Institute (NCI)
  Recruiting
• Pembrolizumab Plus Bevacizumab for Treatment of Brain Metastases in Metastatic Melanoma or Non-small Cell Lung Cancer

  NCT02681549

  Conditions:   Melanoma;   Non-small Cell Lung Cancer;   Brain Metastasis
  Intervention:   Drug: Pembrolizumab plus Bevacizumab
  Sponsor:   Yale University
  Recruiting
• A Randomized Trial of a Combination of Nintedanib/Placebo in Combination With Induction Chemotherapy for Patients With Refractory or First Relapse Acute Myeloid Leukemia

  NCT02665143

  Condition:   Relapsed/Refractory Acute Myeloid Leukemia
  Interventions:   Drug: nintedanib and AML induction;   Drug: AML induction (placebo)
  Sponsors:   Yale University;   Vanderbilt University
  Recruiting
• Personalized Intervention Program: Tobacco Treatment for Patients at Risk for Lung Cancer (PIP)

  NCT02658032

  Conditions:   Smoking Cessation;   Biofeedback
  Interventions:   Behavioral: personalized cessation care;   Behavioral: bio feedback;   Other: standard care
  Sponsor:   Yale University
  Recruiting
• Patient and Parent Preferences for an On-Body Automated Insulin Delivery System

  NCT03534544

  Condition:   Diabetes Mellitus, Type 1
  Intervention:  
  Sponsors:   Joslin Diabetes Center;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
  Recruiting
• Efficacy and Mechanisms of CBT4CBT for Alcohol Use Disorders

  NCT02742246

  Condition:   Alcohol Use Disorder
  Interventions:   Behavioral: Individual clinician-provided CBT;   Behavioral: CBT4CBT
  Sponsor:   Yale University
  Recruiting
• HLAB-002 of ANS-6637 for Alcohol Use Disorder

  NCT03970109

  Condition:   Alcohol Use Disorder
  Interventions:   Drug: ANS-6637;   Drug: Placebo oral tablet
  Sponsor:   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
  Recruiting
• Gut and Intratumoral Microbiome Effect on the Neoadjuvant Chemotherapy-induced Immunosurveillance in Triple Negative Breast Cancer

  NCT03586297

  Condition:   Triple Negative Breast Cancer
  Intervention:  
  Sponsors:   Hackensack Meridian Health;   Breast Cancer Research Foundation
  Recruiting
• Nutrition and Prostate Cancer

  NCT03532308

  Condition:   Prostate Cancer
  Interventions:   Drug: Fermented Soy;   Other: Placebo
  Sponsor:   Yale University
  Recruiting
• A Phase II Study of the BRAF Inhibitor, Vemurafenib, Plus Obinutuzumab in Patients With Previously Untreated Classical Hairy Cell Leukemia

  NCT03410875

  Conditions:   Hairy Cell Leukemia;   Leukemia;   Leukemia, Hairy Cell
  Interventions:   Drug: Vemurafenib;   Drug: Obinutuzumab
  Sponsors:   Memorial Sloan Kettering Cancer Center;   Dana-Farber Cancer Institute;   Yale University
  Recruiting
• Maraviroc to Augment Rehabilitation Outcomes After Stroke

  NCT03172026

  Condition:   Stroke
  Interventions:   Drug: Maraviroc 300 mg;   Behavioral: Rehabilitation therapy;   Drug: Placebo 300 mg
  Sponsors:   University of California, Los Angeles;   Burke Neurological Research Institute;   Yale University
  Recruiting
• A Phase II Evaluation of Afatinibin Patients With Persistent or Recurrent HER2-positive Uterine Serous Carcinoma

  NCT02491099

  Condition:   HER2/Neu+ Uterine Serous Carcinoma
  Intervention:   Drug: Afatinib
  Sponsors:   Yale University;   Boehringer Ingelheim
  Recruiting
• Multisystemic Therapy-Emerging Adults Trial

  NCT02922335

  Condition:   Antisocial Behavior
  Interventions:   Behavioral: Multisystemic Therapy for Emerging Adults;   Behavioral: Enhanced Treatment as Usual
  Sponsors:   University of Massachusetts, Worcester;   National Institute of Mental Health (NIMH);   Oregon Social Learning Center;   Connecticut Department of Children and Families;   North American Family Institute;   Court Support Services Division
  Recruiting
• Fatty Acid Amide Hydrolase (FAAH) Inhibitor Treatment of Cannabis Use Disorder (CUD)

  NCT03386487

  Condition:   Cannabis Use Disorder
  Interventions:   Drug: PF 04457845;   Drug: Placebo Oral Tablet
  Sponsors:   Yale University;   Columbia University;   Johns Hopkins University;   Medical University of South Carolina
  Recruiting
• Rapid Determination Of The Clinical Utility Of Perampanel For The Treatment Of Alcohol Dependence

  NCT02120365

  Condition:   Alcoholism
  Interventions:   Drug: Perampanel;   Drug: Placebo
  Sponsors:   Virginia Commonwealth University;   University of Connecticut;   Yale University
  Recruiting
• A Study in Patients With Different Types of Advanced Cancer (Solid Tumors) to Test Different Doses of BI 907828 in Combination With BI 754091 and 754111

  NCT03964233

  Condition:   Neoplasms
  Interventions:   Drug: BI 907828;   Drug: BI 754091;   Drug: BI 754111
  Sponsor:   Boehringer Ingelheim
  Recruiting
• A Clinical Trial to Evaluate AZD7648 Alone and in Combination With Other Anti-cancer Agents in Patients With Advanced Cancers

  NCT03907969

  Condition:   Advanced Malignancies
  Interventions:   Drug: AZD7648;   Drug: Pegylated liposomal doxorubicin (PLD);   Drug: Olaparib
  Sponsors:   AstraZeneca;   Parexel
  Recruiting
• PROactive Evaluation of Function to Avoid CardioToxicity

  NCT03862131

  Conditions:   Cardiotoxicity;   Breast Cancer;   Lymphoma;   Sarcoma;   Leukemia;   Myeloma;   Lung Cancer
  Intervention:   Device: MyoStrain®
  Sponsors:   Washington University School of Medicine;   Myocardial Solutions
  Recruiting
• Online Therapy for Posttraumatic Stress Symptoms in WTC Responders and Survivors

  NCT03154151

  Condition:   Post-Traumatic Stress Disorder
  Interventions:   Behavioral: Online Cognitive-Behavioral Therapy;   Behavioral: Online Supportive Therapy
  Sponsors:   Icahn School of Medicine at Mount Sinai;   National Institute for Occupational Safety and Health (NIOSH/CDC)
  Recruiting
• A Study Evaluating the Safety and Pharmacokinetics of Atezolizumab Administered in Combination With Hu5F9-G4 to Patients With Relapsed and/or Refractory Acute Myeloid Leukemia

  NCT03922477

  Condition:   Acute Myeloid Leukemia
  Interventions:   Drug: Atezolizumab;   Drug: Hu5F9-G4
  Sponsor:   Hoffmann-La Roche
  Recruiting
• Nivolumab, Ifosfamide, Carboplatin, and Etoposide as Second-Line Therapy in Treating Patients With Refractory or Relapsed Hodgkin Lymphoma

  NCT03016871

  Conditions:   Recurrent Hodgkin Lymphoma;   Refractory Hodgkin Lymphoma
  Interventions:   Drug: Carboplatin;   Drug: Etoposide;   Drug: Ifosfamide;   Other: Laboratory Biomarker Analysis;   Biological: Nivolumab
  Sponsors:   City of Hope Medical Center;   National Cancer Institute (NCI)
  Recruiting
• Zonisamide Treatment of Alcohol Use Disorder: an Evaluation of Efficacy and Mechanism of Action

  NCT02900352

  Condition:   Alcohol Use Disorder
  Interventions:   Drug: Zonisamide;   Drug: Placebo
  Sponsors:   Virginia Commonwealth University;   University of Connecticut;   Yale University;   National Institute on Alcohol Abuse and Alcoholism (NIAAA);   VA Connecticut Healthcare System
  Recruiting
• Sapanisertib and Osimertinib in Treating Patients With Stage IV EGFR Mutation Positive Non-small Cell Lung Cancer After Progression on a Previous EGFR Tyrosine Kinase Inhibitor

  NCT02503722

  Conditions:   Recurrent Lung Non-Small Cell Carcinoma;   Stage III Lung Non-Small Cell Cancer AJCC v7;   Stage IIIA Lung Non-Small Cell Cancer AJCC v7;   Stage IIIB Lung Non-Small Cell Cancer AJCC v7;   Stage IV Lung Non-Small Cell Cancer AJCC v7
  Interventions:   Other: Laboratory Biomarker Analysis;   Drug: Osimertinib;   Other: Pharmacological Study;   Drug: Sapanisertib
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Entinostat, Nivolumab, and Ipilimumab in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery or Locally Advanced or Metastatic HER2-Negative Breast Cancer

  NCT02453620

  Conditions:   Breast Adenocarcinoma;   Invasive Breast Carcinoma;   Metastatic Breast Carcinoma;   Metastatic Malignant Solid Neoplasm;   Stage III Breast Cancer AJCC v7;   Stage IIIA Breast Cancer AJCC v7;   Stage IIIB Breast Cancer AJCC v7;   Stage IIIC Breast Cancer AJCC v7;   Stage IV Breast Cancer AJCC v6 and v7;   Unresectable Solid Neoplasm
  Interventions:   Drug: Entinostat;   Biological: Ipilimumab;   Biological: Nivolumab;   Other: Pharmacogenomic Study;   Other: Pharmacological Study
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Inotuzumab Ozogamicin and Frontline Chemotherapy in Treating Young Adults With Newly Diagnosed B Acute Lymphoblastic Leukemia

  NCT03150693

  Condition:   B Acute Lymphoblastic Leukemia
  Interventions:   Drug: Allopurinol;   Drug: Cytarabine;   Drug: Daunorubicin Hydrochloride;   Drug: Vincristine Sulfate;   Drug: Dexamethasone;   Drug: Pegylated L-Asparaginase;   Drug: Methotrexate;   Procedure: Bone Marrow Aspiration and Biopsy;   Drug: Cyclophosphamide;   Drug: Mercaptopurine;   Biological: Rituximab;   Drug: Doxorubicin;   Drug: Thioguanine;   Biological: Inotuzumab Ozogamicin;   Other: Laboratory Biomarker Analysis
  Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI)
  Recruiting
• Descartes-11 in Multiple Myeloma

  NCT03994705

  Condition:   Multiple Myeloma
  Interventions:   Biological: Descartes-11;   Drug: Fludarabine;   Drug: Cyclophosphamide
  Sponsor:   Cartesian Therapeutics
  Recruiting
• CB-839 HCl in Combination With Carfilzomib and Dexamethasone in Treating Patients With Recurrent or Refractory Multiple Myeloma

  NCT03798678

  Conditions:   Recurrent Plasma Cell Myeloma;   Refractory Plasma Cell Myeloma
  Interventions:   Drug: Carfilzomib;   Drug: Dexamethasone;   Drug: Glutaminase Inhibitor CB-839 Hydrochloride
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• A Study of LY3405105 in Participants With Advanced Cancer

  NCT03770494

  Condition:   Solid Tumor
  Intervention:   Drug: LY3405105
  Sponsor:   Eli Lilly and Company
  Recruiting
• Study of ACTR T Cell Product in Combination With Trastuzumab in Subjects With HER2-Positive Advanced Solid Tumor Cancers

  NCT03680560

  Conditions:   Solid Tumor;   HER-2 Protein Overexpression
  Interventions:   Biological: ACTR T Cell Product;   Drug: Trastuzumab
  Sponsor:   Unum Therapeutics Inc.
  Recruiting
• ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD)

  NCT03113968

  Conditions:   Treatment Resistant Depression;   Electroconvulsive Therapy;   ECT;   Ketamine;   Psychiatric Disorder;   Depression;   Major Depressive Disorder;   Major Depressive Episode;   Unipolar Depression
  Interventions:   Procedure: electroconvulsive therapy (ECT);   Drug: Ketamine
  Sponsors:   The Cleveland Clinic;   Patient-Centered Outcomes Research Institute
  Recruiting
• A Safety and Tolerability Study of NC318 in Subjects With Advanced or Metastatic Solid Tumors

  NCT03665285

  Conditions:   Advanced or Metastatic Solid Tumors;   Head and Neck Squamous Cell Carcinoma;   Non-Small Cell Lung Cancer;   Ovarian Cancer;   Triple Negative Breast Cancer
  Intervention:   Drug: NC318
  Sponsor:   NextCure, Inc.
  Recruiting
• Study of ADCT-301 in Patients With Selected Advanced Solid Tumors

  NCT03621982

  Conditions:   Advanced Solid Tumors With Literature Evidence of CD25(+) Treg Content;   Head and Neck Cancer;   Non-small Cell Lung Cancer;   Gastric Cancer;   Esophageal Cancer;   Pancreas Cancer;   Bladder Cancer;   Renal Cell Carcinoma;   Melanoma;   Triple-negative Breast Cancer;   Ovarian Cancer;   Colo-rectal Cancer
  Intervention:   Drug: ADCT-301
  Sponsor:   ADC Therapeutics S.A.
  Recruiting
• High-quality COPD Care for People With Immune Dysfunction Through Proactive E-consults

  NCT03856879

  Conditions:   COPD;   HIV/AIDS
  Intervention:   Behavioral: Proactive E-consult
  Sponsors:   Seattle Institute for Biomedical and Clinical Research;   VA Puget Sound Health Care System;   Bronx Veterans Medical Research Foundation, Inc;   Washington D.C. Veterans Affairs Medical Center;   VA Eastern Colorado Health Care System;   University of Colorado, Denver;   VA Greater Los Angeles Healthcare System;   Atlanta VA Medical Center;   Baylor College of Medicine;   Michael Debakey Veterans Affairs Medical Center;   Yale University;   VA Connecticut Healthcare System
  Recruiting
• Vision Testing in Patients With Partial Seizures Receiving Either Lyrica or Placebo

  NCT00351611

  Condition:   Epilepsies, Partial
  Interventions:   Drug: Lyrica (pregabalin);   Drug: placebo
  Sponsor:   Pfizer
  Recruiting
• Genetic Testing in Screening Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been or Will Be Removed by Surgery (The ALCHEMIST Screening Trial)

  NCT02194738

  Conditions:   Lung Adenocarcinoma;   Lung Large Cell Carcinoma;   Resectable Lung Non-Small Cell Carcinoma;   Stage IB Lung Non-Small Cell Carcinoma AJCC v7;   Stage IB Lung Squamous Cell Carcinoma AJCC v7;   Stage II Lung Non-Small Cell Cancer AJCC v7;   Stage II Lung Squamous Cell Carcinoma AJCC v7;   Stage IIA Lung Non-Small Cell Carcinoma AJCC v7;   Stage IIA Lung Squamous Cell Carcinoma AJCC v7;   Stage IIB Lung Non-Small Cell Carcinoma AJCC v7;   Stage IIB Lung Squamous Cell Carcinoma AJCC v7;   Stage IIIA Lung Non-Small Cell Cancer AJCC v7;   Stage IIIA Lung Squamous Cell Carcinoma AJCC v7
  Interventions:   Other: Clinical Observation;   Drug: Crizotinib;   Other: Cytology Specimen Collection Procedure;   Drug: Erlotinib;   Drug: Erlotinib Hydrochloride;   Biological: Nivolumab;   Other: Placebo Administration
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Erlotinib Hydrochloride in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been Completely Removed by Surgery (An ALCHEMIST Treatment Trial)

  NCT02193282

  Conditions:   EGFR Exon 19 Deletion Mutation;   EGFR NP_005219.2:p.L858R;   Stage IB Lung Non-Small Cell Carcinoma AJCC v7;   Stage II Lung Non-Small Cell Cancer AJCC v7;   Stage IIA Lung Non-Small Cell Carcinoma AJCC v7;   Stage IIB Lung Non-Small Cell Carcinoma AJCC v7;   Stage IIIA Lung Non-Small Cell Cancer AJCC v7
  Interventions:   Other: Clinical Observation;   Drug: Erlotinib;   Drug: Erlotinib Hydrochloride;   Other: Laboratory Biomarker Analysis;   Other: Placebo Administration
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Ixazomib and Pevonedistat in Treating Patients With Multiple Myeloma That Has Come Back or Does Not Respond to Treatment

  NCT03770260

  Conditions:   Recurrent Plasma Cell Myeloma;   Refractory Plasma Cell Myeloma
  Interventions:   Drug: Ixazomib Citrate;   Drug: Pevonedistat
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Entinostat and Pembrolizumab in Treating Patients With Myelodysplastic Syndrome After DNMTi Therapy Failure

  NCT02936752

  Conditions:   Blasts 21-30 Percent of Bone Marrow Nucleated Cells;   Myelodysplastic Syndrome
  Interventions:   Drug: Entinostat;   Biological: Pembrolizumab
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Study of Durvalumab (MEDI4736) After Chemo-Radiation for Microsatellite Stable Stage II-IV Rectal Cancer

  NCT03102047

  Condition:   Rectal Cancer
  Intervention:   Drug: durvalumab
  Sponsor:   NSABP Foundation Inc
  Recruiting
• Nivolumab in Treating Patients With Autoimmune Disorders or Advanced, Metastatic, or Unresectable Cancer

  NCT03816345

  Conditions:   Advanced Malignant Neoplasm;   Autoimmune Disease;   Crohn Disease;   Dermatomyositis;   Inflammatory Bowel Disease;   Metastatic Malignant Neoplasm;   Multiple Sclerosis;   Rheumatoid Arthritis;   Sjogren Syndrome;   Systemic Lupus Erythematosus;   Systemic Scleroderma;   Ulcerative Colitis;   Unresectable Malignant Neoplasm
  Intervention:   Biological: Nivolumab
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• M6620, Cisplatin, and Radiation Therapy in Treating Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma

  NCT02567422

  Conditions:   Head and Neck Squamous Cell Carcinoma;   Stage III Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma AJCC v6 and v7;   Stage III Oropharyngeal Squamous Cell Carcinoma AJCC v7;   Stage IV Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma AJCC v7;   Stage IV Oropharyngeal Squamous Cell Carcinoma AJCC v7;   Stage IVA Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma AJCC v7;   Stage IVA Oropharyngeal Squamous Cell Carcinoma AJCC v7;   Stage IVB Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma AJCC v7;   Stage IVB Oropharyngeal Squamous Cell Carcinoma AJCC v7;   Stage IVC Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma AJCC v7;   Stage IVC Oropharyngeal Squamous Cell Carcinoma AJCC v7
  Interventions:   Drug: ATR Kinase Inhibitor M6620;   Drug: Cisplatin;   Other: Laboratory Biomarker Analysis;   Other: Pharmacological Study;   Radiation: Radiation Therapy
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Anti-ICOS Monoclonal Antibody MEDI-570 in Treating Patients With Relapsed or Refractory Peripheral T-cell Lymphoma Follicular Variant or Angioimmunoblastic T-cell Lymphoma

  NCT02520791

  Conditions:   Follicular T-Cell Lymphoma;   Grade 1 Follicular Lymphoma;   Grade 2 Follicular Lymphoma;   Grade 3a Follicular Lymphoma;   Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma;   Recurrent Angioimmunoblastic T-Cell Lymphoma;   Recurrent Follicular Lymphoma;   Recurrent Mature T- Cell and NK-Cell Non-Hodgkin Lymphoma;   Recurrent Mycosis Fungoides;   Recurrent Primary Cutaneous T-Cell Non-Hodgkin Lymphoma;   Refractory Angioimmunoblastic T-Cell Lymphoma;   Refractory Follicular Lymphoma;   Refractory Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma;   Stage IB Mycosis Fungoides AJCC v7;   Stage II Mycosis Fungoides AJCC v7;   Stage III Cutaneous T-Cell Non-Hodgkin Lymphoma;   Stage III Mycosis Fungoides AJCC v7;   Stage IV Cutaneous T-Cell Non-Hodgkin Lymphoma;   Stage IV Mycosis Fungoides AJCC v7
  Interventions:   Biological: Anti-ICOS Monoclonal Antibody MEDI-570;   Other: Laboratory Biomarker Analysis;   Other: Pharmacological Study
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Tazemetostat and Pembrolizumab in Treating Patients With Locally Advanced or Metastatic Urothelial Carcinoma

  NCT03854474

  Conditions:   Advanced Urothelial Carcinoma;   Locally Advanced Urothelial Carcinoma;   Metastatic Bladder Urothelial Carcinoma;   Metastatic Urothelial Carcinoma;   Stage III Bladder Cancer AJCC v8;   Stage IIIA Bladder Cancer AJCC v8;   Stage IIIB Bladder Cancer AJCC v8;   Stage IV Bladder Cancer AJCC v8;   Stage IVA Bladder Cancer AJCC v8;   Stage IVB Bladder Cancer AJCC v8
  Interventions:   Biological: Pembrolizumab;   Drug: Tazemetostat
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Sapanisertib in Treating Patients With Locally Advanced or Metastatic Bladder Cancer With TSC1 and/or TSC2 Mutations

  NCT03047213

  Conditions:   Locally Advanced Bladder Urothelial Carcinoma;   Metastatic Transitional Cell Carcinoma;   Metastatic Urothelial Carcinoma;   Recurrent Bladder Carcinoma;   Stage III Bladder Urothelial Carcinoma AJCC v6 and v7;   Stage IV Bladder Urothelial Carcinoma AJCC v7
  Interventions:   Other: Laboratory Biomarker Analysis;   Drug: Sapanisertib
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Pembrolizumab and Recombinant Interleukin-12 in Treating Patients With Solid Tumors

  NCT03030378

  Conditions:   Metastatic Malignant Solid Neoplasm;   Unresectable Solid Neoplasm
  Interventions:   Other: Laboratory Biomarker Analysis;   Biological: Pembrolizumab;   Biological: Recombinant Interleukin-12
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• A Study to Investigate the Safety and Efficacy of ABBV-105 and Upadacitinib Given Alone or in Combination in Participants With Moderately to Severely Active Systemic Lupus Erythematosus

  NCT03978520

  Condition:   Systemic Lupus Erythematosus (SLE)
  Interventions:   Drug: ABBV-105;   Drug: Placebo for ABBV-105;   Drug: Upadacitinib;   Drug: Placebo for upadacitinib
  Sponsor:   AbbVie
  Recruiting
• A Study to Evaluate the Efficacy and Safety of BIIB093 in Participants With Brain Contusion

  NCT03954041

  Condition:   Brain Contusion
  Interventions:   Drug: BIIB093;   Drug: Placebo
  Sponsor:   Biogen
  Recruiting
• Osimertinib With or Without Bevacizumab in Treating Patients With EGFR Positive Non-small Cell Lung Cancer and Brain Metastases

  NCT02971501

  Conditions:   Lung Carcinoma Metastatic in the Brain;   Lung Non-Small Cell Carcinoma
  Interventions:   Biological: Bevacizumab;   Other: Laboratory Biomarker Analysis;   Drug: Osimertinib
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

  NCT03851445

  Condition:   Previously Treated Non-Small Cell Lung Cancer
  Intervention:   Drug: Screening Platform
  Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• Testing Maintenance Immunotherapy Versus Observation in Patients With Oropharynx Cancer

  NCT03811015

  Conditions:   Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8;   Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8;   Pathologic Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8;   Pathologic Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
  Interventions:   Drug: Cisplatin;   Radiation: Intensity-Modulated Radiation Therapy;   Biological: Nivolumab;   Other: Patient Observation
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Firstline Pembrolizumab Alone or in Combination With Pemetrexed and Carboplatin in Induction/Maintenance or Postprogression in Treating Patients With Stage IV Non-squamous Non-small Cell Lung Cancer

  NCT03793179

  Conditions:   Lung Non-Squamous Non-Small Cell Carcinoma;   Stage IIIB Lung Cancer AJCC v8;   Stage IIIC Lung Cancer AJCC v8;   Stage IVA Lung Cancer AJCC v8
  Interventions:   Drug: Carboplatin;   Biological: Pembrolizumab;   Drug: Pemetrexed
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Gemcitabine Hydrochloride and Cisplatin With or Without Nab-Paclitaxel in Treating Patients With Newly Diagnosed Advanced Biliary Tract Cancers

  NCT03768414

  Conditions:   Stage III Distal Bile Duct Cancer AJCC v8;   Stage III Gallbladder Cancer AJCC v8;   Stage III Intrahepatic Cholangiocarcinoma AJCC v8;   Stage IIIA Distal Bile Duct Cancer AJCC v8;   Stage IIIA Gallbladder Cancer AJCC v8;   Stage IIIA Intrahepatic Cholangiocarcinoma AJCC v8;   Stage IIIB Distal Bile Duct Cancer AJCC v8;   Stage IIIB Gallbladder Cancer AJCC v8;   Stage IIIB Intrahepatic Cholangiocarcinoma AJCC v8;   Stage IV Distal Bile Duct Cancer AJCC v8;   Stage IV Gallbladder Cancer AJCC v8;   Stage IV Intrahepatic Cholangiocarcinoma AJCC v8;   Stage IVA Gallbladder Cancer AJCC v8;   Stage IVB Gallbladder Cancer AJCC v8;   Unresectable Extrahepatic Bile Duct Carcinoma;   Unresectable Gallbladder Carcinoma;   Unresectable Intrahepatic Cholangiocarcinoma
  Interventions:   Drug: Cisplatin;   Drug: Gemcitabine Hydrochloride;   Drug: Nab-paclitaxel
  Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• A Study in Patients Previously Enrolled in a Genentech and/or F. Hoffmann-La Roche Ltd Sponsored Atezolizumab Study

  NCT03768063

  Condition:   Cancer
  Intervention:   Drug: Atezolizumab
  Sponsor:   Hoffmann-La Roche
  Recruiting
• Serum Tumor Marker Directed Disease Monitoring in Patients With Hormone Receptor Positive Her2 Negative Metastatic Breast Cancer

  NCT03723928

  Conditions:   Anatomic Stage IV Breast Cancer AJCC v8;   Estrogen Receptor Positive;   HER2/Neu Negative;   Progesterone Receptor Positive;   Prognostic Stage IV Breast Cancer AJCC v8;   Elevated CA15-3 or CEA or CA27-29
  Interventions:   Other: Usual care disease monitoring;   Other: Serum Tumor Marker directed disease monitoring;   Other: Quality-of-Life Assessment;   Other: Anxiety Questionnaire Administration
  Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• Pembrolizumab Compared to Standard of Care Observation in Treating Patients With Completely Resected Stage I-III Merkel Cell Cancer

  NCT03712605

  Conditions:   Pathologic Stage I Merkel Cell Carcinoma AJCC v8;   Pathologic Stage II Merkel Cell Carcinoma AJCC v8;   Pathologic Stage IIA Merkel Cell Carcinoma AJCC v8;   Pathologic Stage IIB Merkel Cell Carcinoma AJCC v8;   Pathologic Stage III Merkel Cell Carcinoma AJCC v8;   Pathologic Stage IIIA Merkel Cell Carcinoma AJCC v8;   Pathologic Stage IIIB Merkel Cell Carcinoma AJCC v8
  Interventions:   Other: Best Practice;   Biological: Pembrolizumab;   Radiation: Radiation Therapy
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Savolitinib in Treating Participants With MET Amplified Metastatic or Unresectable Colorectal Cancer

  NCT03592641

  Conditions:   Colon Adenocarcinoma;   Colorectal Carcinoma;   Rectal Adenocarcinoma;   Stage III Colon Cancer AJCC v8;   Stage III Rectal Cancer AJCC v8;   Stage IIIA Colon Cancer AJCC v8;   Stage IIIA Rectal Cancer AJCC v8;   Stage IIIB Colon Cancer AJCC v8;   Stage IIIB Rectal Cancer AJCC v8;   Stage IIIC Colon Cancer AJCC v8;   Stage IIIC Rectal Cancer AJCC v8;   Stage IV Colon Cancer AJCC v8;   Stage IV Rectal Cancer AJCC v8;   Stage IVA Colon Cancer AJCC v8;   Stage IVA Rectal Cancer AJCC v8;   Stage IVB Colon Cancer AJCC v8;   Stage IVB Rectal Cancer AJCC v8;   Stage IVC Colon Cancer AJCC v8;   Stage IVC Rectal Cancer AJCC v8
  Intervention:   Drug: Savolitinib
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• S1702 Isatuximab in Treating Patients With Relapsed or Refractory Primary Amyloidosis

  NCT03499808

  Conditions:   Amorphous, Eosinophilic, and Acellular Deposit;   Constipation;   Diarrhea;   Early Satiety;   Gastrointestinal Hemorrhage;   Hepatomegaly;   Lymphadenopathy;   Macroglossia;   Nausea;   Primary Systemic Amyloidosis;   Purpura;   Recurrent Primary Amyloidosis;   Refractory Primary Amyloidosis
  Interventions:   Biological: Isatuximab;   Other: Laboratory Biomarker Analysis
  Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• Olaparib in Treating Patients With Advanced Glioma, Cholangiocarcinoma, or Solid Tumors With IDH1 or IDH2 Mutations

  NCT03212274

  Conditions:   Advanced Malignant Solid Neoplasm;   Glioblastoma;   Recurrent Cholangiocarcinoma;   Recurrent Glioma;   Recurrent Malignant Solid Neoplasm;   WHO Grade II Glioma;   WHO Grade III Glioma
  Intervention:   Drug: Olaparib
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• A Phase 2 Study of Cediranib in Combination With Olaparib in Advanced Solid Tumors

  NCT02498613

  Conditions:   Metastatic Pancreatic Adenocarcinoma;   Pancreatic Ductal Adenocarcinoma;   Stage III Breast Cancer AJCC v7;   Stage III Lung Non-Small Cell Cancer AJCC v7;   Stage III Lung Small Cell Carcinoma AJCC v7;   Stage III Pancreatic Cancer AJCC v6 and v7;   Stage IIIA Breast Cancer AJCC v7;   Stage IIIA Lung Non-Small Cell Cancer AJCC v7;   Stage IIIA Lung Small Cell Carcinoma AJCC v7;   Stage IIIB Breast Cancer AJCC v7;   Stage IIIB Lung Non-Small Cell Cancer AJCC v7;   Stage IIIB Lung Small Cell Carcinoma AJCC v7;   Stage IIIC Breast Cancer AJCC v7;   Stage IV Breast Cancer AJCC v6 and v7;   Stage IV Lung Non-Small Cell Cancer AJCC v7;   Stage IV Lung Small Cell Carcinoma AJCC v7;   Stage IV Pancreatic Cancer AJCC v6 and v7;   Triple-Negative Breast Carcinoma;   Unresectable Pancreatic Carcinoma
  Interventions:   Other: 18F-Fluoromisonidazole;   Drug: Cediranib;   Drug: Cediranib Maleate;   Other: Laboratory Biomarker Analysis;   Drug: Olaparib;   Procedure: Positron Emission Tomography
  Sponsors:   National Cancer Institute (NCI);   AstraZeneca
  Recruiting
• Pembrolizumab With or Without Stereotactic Body Radiation Therapy in Treating Patients With Advanced or Metastatic Merkel Cell Cancer

  NCT03304639

  Conditions:   Stage III Merkel Cell Carcinoma AJCC v7;   Stage IIIA Merkel Cell Carcinoma AJCC v7;   Stage IIIB Merkel Cell Carcinoma AJCC v7;   Stage IV Merkel Cell Carcinoma AJCC v7
  Interventions:   Biological: Pembrolizumab;   Radiation: Stereotactic Body Radiation Therapy
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Pembrolizumab in Treating Patients With Locally Advanced Bladder Cancer

  NCT03244384

  Conditions:   Stage II Bladder Urothelial Carcinoma AJCC v6 and v7;   Stage III Bladder Urothelial Carcinoma AJCC v6 and v7
  Interventions:   Other: Clinical Observation;   Other: Laboratory Biomarker Analysis;   Biological: Pembrolizumab;   Other: Pharmacological Study;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Vemurafenib and Cobimetinib in Treating Patients With BRAF V600E Mutation Positive Craniopharyngioma

  NCT03224767

  Conditions:   BRAF V600E Mutation Present;   Papillary Craniopharyngioma
  Interventions:   Drug: Vemurafenib;   Drug: Cobimetinib;   Other: Laboratory Biomarker Analysis;   Other: Quality-of-Life Assessment
  Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI)
  Recruiting
• Evaluation of Treatment Strategies for Severe CaLcIfic Coronary Arteries: Orbital Atherectomy vs. Conventional Angioplasty Technique Prior to Implantation of Drug-Eluting StEnts: The ECLIPSE Trial

  NCT03108456

  Conditions:   Coronary Artery Disease;   Ischemic Heart Disease;   Non ST Segment Elevation Myocardial Infarction
  Interventions:   Device: Orbital Atherectomy;   Device: Balloon
  Sponsors:   Cardiovascular Systems Inc;   Cardiovascular Research Foundation, New York
  Recruiting
• Olaparib and Ramucirumab in Treating Patients With Metastatic or Locally Recurrent Gastric or Gastroesophageal Junction Cancer That Cannot Be Removed by Surgery

  NCT03008278

  Conditions:   Metastatic Esophageal Carcinoma;   Metastatic Gastric Carcinoma;   Metastatic Gastroesophageal Junction Adenocarcinoma;   Recurrent Esophageal Carcinoma;   Recurrent Gastric Carcinoma;   Recurrent Gastroesophageal Junction Adenocarcinoma;   Stage III Esophageal Cancer AJCC v7;   Stage III Gastric Cancer AJCC v7;   Stage IIIA Esophageal Cancer AJCC v7;   Stage IIIA Gastric Cancer AJCC v7;   Stage IIIB Esophageal Cancer AJCC v7;   Stage IIIB Gastric Cancer AJCC v7;   Stage IIIC Esophageal Cancer AJCC v7;   Stage IIIC Gastric Cancer AJCC v7;   Stage IV Esophageal Cancer AJCC v7;   Stage IV Gastric Cancer AJCC v7;   Unresectable Esophageal Carcinoma;   Unresectable Gastric Carcinoma;   Unresectable Gastroesophageal Junction Adenocarcinoma
  Interventions:   Drug: Olaparib;   Biological: Ramucirumab
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Pembrolizumab in Treating Patients With Triple-Negative Breast Cancer

  NCT02954874

  Conditions:   Invasive Breast Carcinoma;   Stage 0 Breast Cancer AJCC v6 and v7;   Stage I Breast Cancer AJCC v7;   Stage IA Breast Cancer AJCC v7;   Stage IB Breast Cancer AJCC v7;   Stage II Breast Cancer AJCC v6 and v7;   Stage IIA Breast Cancer AJCC v6 and v7;   Stage IIB Breast Cancer AJCC v6 and v7;   Stage III Breast Cancer AJCC v7;   Stage IIIA Breast Cancer AJCC v7;   Stage IIIB Breast Cancer AJCC v7;   Stage IIIC Breast Cancer AJCC v7;   Triple-Negative Breast Carcinoma
  Interventions:   Other: Laboratory Biomarker Analysis;   Other: Patient Observation;   Biological: Pembrolizumab;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration;   Radiation: Radiation Therapy
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Aspirin in Preventing Recurrence of Cancer in Patients With HER2 Negative Stage II-III Breast Cancer After Chemotherapy, Surgery, and/or Radiation Therapy

  NCT02927249

  Condition:   Node Positive HER2 Negative Breast Cancer
  Interventions:   Other: Placebo;   Drug: Aspirin
  Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI);   United States Department of Defense;   Bayer;   Canadian Cancer Trials Group
  Recruiting
• Olaparib With or Without Atezolizumab in Treating Patients With Locally Advanced Unresectable or Metastatic Non-HER2-Positive Breast Cancer

  NCT02849496

  Conditions:   Locally Advanced Unresectable Breast Carcinoma;   Metastatic Breast Carcinoma;   Stage III Breast Cancer AJCC v7;   Stage IIIA Breast Cancer AJCC v7;   Stage IIIB Breast Cancer AJCC v7;   Stage IIIC Breast Cancer AJCC v7;   Stage IV Breast Cancer AJCC v6 and v7
  Interventions:   Drug: Atezolizumab;   Drug: Olaparib;   Other: Questionnaire Administration
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Cabozantinib S-Malate, Crizotinib, Savolitinib, or Sunitinib Malate in Treating Patients With Locally Advanced or Metastatic Kidney Cancer

  NCT02761057

  Conditions:   Stage III Renal Cell Cancer AJCC v7;   Stage IV Renal Cell Cancer AJCC v7;   Type 1 Papillary Renal Cell Carcinoma;   Type 2 Papillary Renal Cell Carcinoma;   Unresectable Renal Cell Carcinoma
  Interventions:   Drug: Cabozantinib;   Drug: Cabozantinib S-malate;   Drug: Crizotinib;   Drug: Savolitinib;   Drug: Sunitinib;   Drug: Sunitinib Malate
  Sponsors:   National Cancer Institute (NCI);   Canadian Cancer Trials Group
  Recruiting
• Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery

  NCT02734537

  Conditions:   Head and Neck Squamous Cell Carcinoma;   Hypopharyngeal Squamous Cell Carcinoma;   Laryngeal Squamous Cell Carcinoma;   Laryngeal Squamous Cell Carcinoma, Spindle Cell Variant;   Lip and Oral Cavity Squamous Cell Carcinoma;   p16INK4a Negative Oropharyngeal Squamous Cell Carcinoma;   Stage III Hypopharyngeal Carcinoma AJCC v8;   Stage III Laryngeal Cancer AJCC v8;   Stage III Lip and Oral Cavity Cancer AJCC v8;   Stage III Oral Cavity Verrucous Carcinoma;   Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8;   Stage IVA Hypopharyngeal Carcinoma AJCC v8;   Stage IVA Laryngeal Cancer AJCC v8;   Stage IVA Lip and Oral Cavity Cancer AJCC v8;   Stage IVA Oral Cavity Verrucous Carcinoma;   Stage IVA Oropharyngeal (p16-Negative) Carcinoma AJCC v8
  Interventions:   Drug: Cisplatin;   Radiation: Intensity-Modulated Radiation Therapy;   Other: Laboratory Biomarker Analysis
  Sponsors:   ECOG-ACRIN Cancer Research Group;   National Cancer Institute (NCI)
  Recruiting
• Collection and Storage of Tissue and Blood Samples From Patients With Cancer

  NCT02474160

  Conditions:   Lymphoma;   Malignant Neoplasm;   Malignant Solid Neoplasm;   Metastatic Malignant Solid Neoplasm;   Plasma Cell Leukemia;   Plasma Cell Myeloma;   Recurrent Lymphoma;   Recurrent Malignant Solid Neoplasm;   Recurrent Plasma Cell Myeloma
  Intervention:   Other: Cytology Specimen Collection Procedure
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• VX-970 and Irinotecan Hydrochloride in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery

  NCT02595931

  Conditions:   Advanced Malignant Solid Neoplasm;   Metastatic Malignant Neoplasm;   Refractory Malignant Neoplasm;   Unresectable Malignant Neoplasm
  Interventions:   Drug: ATR Kinase Inhibitor M6620;   Drug: Irinotecan;   Drug: Irinotecan Hydrochloride
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Doxorubicin Hydrochloride and Cyclophosphamide Followed by Paclitaxel With or Without Carboplatin in Treating Patients With Triple-Negative Breast Cancer

  NCT02488967

  Conditions:   Breast Adenocarcinoma;   Estrogen Receptor Negative;   HER2/Neu Negative;   Progesterone Receptor Negative;   Stage IB Breast Cancer;   Stage IIA Breast Cancer;   Stage IIB Breast Cancer;   Stage IIIA Breast Cancer;   Stage IIIC Breast Cancer;   Triple-Negative Breast Carcinoma
  Interventions:   Drug: Carboplatin;   Drug: Cyclophosphamide;   Drug: Doxorubicin Hydrochloride;   Other: Laboratory Biomarker Analysis;   Drug: Paclitaxel
  Sponsors:   NRG Oncology;   National Cancer Institute (NCI)
  Recruiting
• Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

  NCT02465060

  Conditions:   Advanced Malignant Solid Neoplasm;   Bladder Carcinoma;   Breast Carcinoma;   Cervical Carcinoma;   Colon Carcinoma;   Colorectal Carcinoma;   Endometrial Carcinoma;   Esophageal Carcinoma;   Gastric Carcinoma;   Glioma;   Head and Neck Carcinoma;   Kidney Carcinoma;   Liver and Intrahepatic Bile Duct Carcinoma;   Lung Carcinoma;   Lymphoma;   Malignant Uterine Neoplasm;   Melanoma;   Ovarian Carcinoma;   Pancreatic Carcinoma;   Plasma Cell Myeloma;   Prostate Carcinoma;   Rectal Carcinoma;   Recurrent Bladder Carcinoma;   Recurrent Breast Carcinoma;   Recurrent Cervical Carcinoma;   Recurrent Colon Carcinoma;   Recurrent Colorectal Carcinoma;   Recurrent Esophageal Carcinoma;   Recurrent Gastric Carcinoma;   Recurrent Glioma;   Recurrent Head and Neck Carcinoma;   Recurrent Liver Carcinoma;   Recurrent Lung Carcinoma;   Recurrent Lymphoma;   Recurrent Malignant Solid Neoplasm;   Recurrent Melanoma;   Recurrent Ovarian Carcinoma;   Recurrent Pancreatic Carcinoma;   Recurrent Plasma Cell Myeloma;   Recurrent Prostate Carcinoma;   Recurrent Rectal Carcinoma;   Recurrent Skin Carcinoma;   Recurrent Thyroid Gland Carcinoma;   Recurrent Uterine Corpus Carcinoma;   Refractory Lymphoma;   Refractory Malignant Solid Neoplasm;   Refractory Plasma Cell Myeloma;   Skin Carcinoma;   Thyroid Gland Carcinoma;   Uterine Corpus Cancer
  Interventions:   Drug: Adavosertib;   Drug: Afatinib;   Drug: Afatinib Dimaleate;   Drug: Binimetinib;   Drug: Capivasertib;   Drug: Copanlisib;   Drug: Copanlisib Hydrochloride;   Drug: Crizotinib;   Other: Cytology Specimen Collection Procedure;   Drug: Dabrafenib;   Drug: Dabrafenib Mesylate;   Drug: Dasatinib;   Drug: Defactinib;   Drug: Defactinib Hydrochloride;   Drug: Erdafitinib;   Drug: FGFR Inhibitor AZD4547;   Drug: Ipatasertib;   Other: Laboratory Biomarker Analysis;   Drug: Larotrectinib;   Drug: Larotrectinib Sulfate;   Biological: Nivolumab;   Drug: Osimertinib;   Drug: Palbociclib;   Biological: Pertuzumab;   Drug: PI3K-beta Inhibitor GSK2636771;   Drug: Sapanisertib;   Drug: Sunitinib Malate;   Drug: Taselisib;   Drug: Trametinib;   Biological: Trastuzumab;   Biological: Trastuzumab Emtansine;   Drug: Ulixertinib;   Drug: Vismodegib
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Nivolumab With or Without Ipilimumab in Treating Patients With Refractory Metastatic Anal Canal Cancer

  NCT02314169

  Conditions:   Anal Canal Squamous Cell Carcinoma;   Metastatic Anal Canal Carcinoma;   Stage IV Anal Canal Cancer AJCC v6 and v7
  Interventions:   Biological: Ipilimumab;   Other: Laboratory Biomarker Analysis;   Biological: Nivolumab
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Nivolumab in Eliminating Minimal Residual Disease and Preventing Relapse in Patients With Acute Myeloid Leukemia in Remission After Chemotherapy

  NCT02275533

  Condition:   Acute Myeloid Leukemia
  Interventions:   Other: Clinical Observation;   Other: Laboratory Biomarker Analysis;   Biological: Nivolumab
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Dabrafenib and Trametinib Followed by Ipilimumab and Nivolumab or Ipilimumab and Nivolumab Followed by Dabrafenib and Trametinib in Treating Patients With Stage III-IV BRAFV600 Melanoma

  NCT02224781

  Conditions:   Metastatic Melanoma;   Recurrent Melanoma;   Stage III Cutaneous Melanoma AJCC v7;   Stage IIIA Cutaneous Melanoma AJCC v7;   Stage IIIB Cutaneous Melanoma AJCC v7;   Stage IIIC Cutaneous Melanoma AJCC v7;   Stage IV Cutaneous Melanoma AJCC v6 and v7;   Unresectable Cutaneous Melanoma
  Interventions:   Drug: Dabrafenib;   Drug: Dabrafenib Mesylate;   Biological: Ipilimumab;   Biological: Nivolumab;   Other: Quality-of-Life Assessment;   Drug: Trametinib;   Drug: Trametinib Dimethyl Sulfoxide
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Standard or Comprehensive Radiation Therapy in Treating Patients With Early-Stage Breast Cancer Previously Treated With Chemotherapy and Surgery

  NCT01872975

  Conditions:   Stage IB Breast Cancer;   Stage II Breast Cancer
  Interventions:   Radiation: regional nodal XRT;   Radiation: chestwall XRT;   Radiation: WBI
  Sponsors:   NSABP Foundation Inc;   National Cancer Institute (NCI);   Radiation Therapy Oncology Group
  Recruiting
• MRI and Mammography Before Surgery in Patients With Stage I-II Breast Cancer

  NCT01805076

  Conditions:   Estrogen Receptor-negative Breast Cancer;   Progesterone Receptor-negative Breast Cancer;   Stage IA Breast Cancer;   Stage IB Breast Cancer;   Stage II Breast Cancer;   Triple-negative Breast Cancer
  Interventions:   Procedure: Breast surgery;   Procedure: Magnetic resonance imaging;   Procedure: Mammography
  Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI);   American College of Radiology Imaging Network
  Recruiting
• S0820, Adenoma and Second Primary Prevention Trial

  NCT01349881

  Condition:   Colorectal Neoplasms
  Interventions:   Drug: Eflornithine placebo & sulindac placebo;   Drug: eflornithine & sulindac placebo;   Drug: Eflornithine placebo & sulindac;   Drug: Eflornithine plus sulindac
  Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI);   Cancer Prevention Pharmaceuticals, Inc.
  Recruiting
• Combination Chemotherapy With or Without Temsirolimus in Treating Patients With Intermediate Risk Rhabdomyosarcoma

  NCT02567435

  Conditions:   Alveolar Rhabdomyosarcoma;   Botryoid-Type Embryonal Rhabdomyosarcoma;   Embryonal Rhabdomyosarcoma;   Rhabdomyosarcoma;   Sclerosing Rhabdomyosarcoma;   Spindle Cell Rhabdomyosarcoma
  Interventions:   Drug: Cyclophosphamide;   Biological: Dactinomycin;   Drug: Irinotecan Hydrochloride;   Other: Laboratory Biomarker Analysis;   Other: Questionnaire Administration;   Radiation: Radiation Therapy;   Drug: Temsirolimus;   Drug: Vincristine Sulfate;   Drug: Vinorelbine
  Sponsor:   National Cancer Institute (NCI)
  Recruiting
• Study of Crenolanib vs Midostaurin Following Induction Chemotherapy and Consolidation Therapy in Newly Diagnosed FLT3 Mutated AML

  NCT03258931

  Condition:   Newly Diagnosed FLT3 Mutated AML
  Interventions:   Drug: Crenolanib;   Drug: Midostaurin;   Drug: Cytarabine;   Drug: Duanorubicin
  Sponsor:   Arog Pharmaceuticals, Inc.
  Recruiting
• Comparison of MENOPUR Liquid and Powder in Women Undergoing ART

  NCT04163458

  Condition:   Infertility
  Interventions:   Drug: MENOPUR solution for injection in pre-filled pen, 1200 IU/1.92 mL;   Drug: MENOPUR powder and solvent for solution for injection, 75 IU;   Other: Placebo (for MENOPUR solution for injection in pre-filled pen);   Other: Placebo (for MENOPUR powder and solvent for solution for injection)
  Sponsor:   Ferring Pharmaceuticals
  Recruiting
• A Medical Research Study Designed to Determine if Venglustat Can be a Future Treatment for ADPKD Patients

  NCT03523728

  Condition:   Polycystic Kidney, Autosomal Dominant
  Interventions:   Drug: Venglustat GZ402671;   Drug: Placebo
  Sponsor:   Genzyme, a Sanofi Company
  Recruiting
• A First-in-Humans Dose Finding Study for an Aryl Hydrocarbon Receptor Inhibitor (AhRi) in Patients With Advanced Cancer

  NCT04069026

  Condition:   Advanced Solid Tumors
  Intervention:   Drug: BAY2416964
  Sponsor:   Bayer
  Recruiting
• The ENROUTE Transcarotid Neuroprotection System (ENROUTE Transcarotid NPS) DW-MRI Evaluation

  NCT03982420

  Conditions:   Carotid Artery Diseases;   Carotid Atherosclerosis;   Carotid Stenosis;   Carotid Artery Plaque;   Carotid Disease
  Intervention:   Procedure: Transcarotid Revascularization (TCAR)
  Sponsor:   Silk Road Medical
  Recruiting
• A Study of AG-636 in the Treatment of Subjects With Advanced Lymphoma

  NCT03834584

  Condition:   Lymphoma
  Intervention:   Drug: AG-636
  Sponsor:   Agios Pharmaceuticals, Inc.
  Recruiting
• A Study Exploring the Safety and Tolerability of INCB081776 in Participants With Advanced Solid Tumors

  NCT03522142

  Condition:   Advanced Solid Tumors
  Interventions:   Drug: INCB081776;   Drug: Nivolumab
  Sponsor:   Incyte Corporation
  Recruiting
• Confocal Laser Endomicroscopy as an Imaging Biomarker for the Diagnosis of Pancreatic Cystic Lesions

  NCT03492151

  Condition:   Pancreatic Cyst
  Intervention:  
  Sponsors:   Ohio State University;   American College of Gastroenterology;   The National Pancreas Foundation
  Recruiting
• This Study Aims to Find the Best Dose of BI 907828 in Patients With Different Types of Advanced Cancer (Solid Tumors)

  NCT03449381

  Condition:   Neoplasms
  Intervention:   Drug: BI 907828
  Sponsor:   Boehringer Ingelheim
  Recruiting
• Study of AG-270 in Participants With Advanced Solid Tumors or Lymphoma With MTAP Loss

  NCT03435250

  Conditions:   Advanced Solid Tumors;   Lymphoma
  Interventions:   Drug: AG-270;   Drug: docetaxel;   Drug: nab-paclitaxel;   Drug: gemcitabine
  Sponsor:   Agios Pharmaceuticals, Inc.
  Recruiting
• Study to Explore the Mechanism of Action of Ocrelizumab and B-Cell Biology in Participants With Relapsing Multiple Sclerosis (RMS) or Primary Progressive Multiple Sclerosis (PPMS)

  NCT02688985

  Conditions:   Relapsing Multiple Sclerorsis;   Multiple Sclerosis, Primary Progressive
  Interventions:   Drug: Ocrelizumab;   Procedure: Lumbar Puncture;   Drug: Methyloprednisolone;   Drug: Antihistamine
  Sponsor:   Genentech, Inc.
  Recruiting
• M8891 First in Human in Solid Tumors

  NCT03138538

  Condition:   Advanced Solid Tumors
  Intervention:   Drug: M8891
  Sponsors:   EMD Serono Research & Development Institute, Inc.;   Merck KGaA, Darmstadt, Germany
  Recruiting
• A Phase 1 Trial of a Novel XPO1 Inhibitor in Patients With Advanced Solid Tumors

  NCT02667873

  Condition:   Solid Tumors
  Intervention:   Drug: SL-801
  Sponsor:   Stemline Therapeutics, Inc.
  Recruiting
• A Study to Assess the Effects of RO6889450 in Participants With Schizophrenia or Schizoaffective Disorder and Negative Symptoms

  NCT03669640

  Condition:   Schizophrenia, Schizoaffective Disorder
  Interventions:   Drug: RO6889450;   Drug: Placebo
  Sponsor:   Hoffmann-La Roche
  Recruiting
• Study of the Efficacy and Safety of Tesevatinib in Subjects With ADPKD

  NCT03203642

  Conditions:   Autosomal Dominant Polycystic Kidney;   ADPKD
  Interventions:   Drug: Tesevatinib;   Drug: Placebo
  Sponsor:   Kadmon Corporation, LLC
  Recruiting
• A Study to Evaluate Efficacy, Safety, Tolerability, and Pharmacokinetics of 3 Dose Levels of TAK-831 in Adjunctive Treatment of Adult Participants With Negative Symptoms of Schizophrenia

  NCT03382639

  Condition:   Schizophrenia
  Interventions:   Drug: TAK-831;   Drug: Placebo
  Sponsor:   Millennium Pharmaceuticals, Inc.
  Recruiting
• Biospecimen Analysis in Determining Effects of Chemotherapy on Fertility in Osteosarcoma Survivors

  NCT03206450

  Conditions:   Cancer Survivor;   Osteosarcoma
  Interventions:   Procedure: Biospecimen Collection;   Other: Laboratory Biomarker Analysis;   Other: Questionnaire Administration
  Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
  Recruiting
• Ficlatuzumab w/wo Cetuximab in Patients w/Cetuximab-Resistant, Recurrent or Metastatic Head/Neck Squamous Cell Carcinoma

  NCT03422536

  Conditions:   Head and Neck Basaloid Carcinoma;   Recurrent Head and Neck Squamous Cell Carcinoma;   Recurrent Oropharyngeal Squamous Cell Carcinoma;   Squamous Cell Carcinoma of Unknown Primary Origin;   Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity;   Stage IV Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity;   Stage IV Nasopharyngeal Keratinizing Squamous Cell Carcinoma;   Stage IV Oropharyngeal Squamous Cell Carcinoma;   Stage IVA Lip and Oral Cavity Squamous Cell Carcinoma;   Stage IVA Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma;   Stage IVA Nasopharyngeal Keratinizing Squamous Cell Carcinoma;   Stage IVA Oropharyngeal Squamous Cell Carcinoma;   Stage IVB Lip and Oral Cavity Squamous Cell Carcinoma;   Stage IVB Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma;   Stage IVB Nasopharyngeal Keratinizing Squamous Cell Carcinoma;   Stage IVB Oropharyngeal Squamous Cell Carcinoma;   Stage IVC Lip and Oral Cavity Squamous Cell Carcinoma;   Stage IVC Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma;   Stage IVC Nasopharyngeal Keratinizing Squamous Cell Carcinoma;   Stage IVC Oropharyngeal Squamous Cell Carcinoma;   Head and Neck Cancer;   Oropharyngeal Cancer;   HNSCC;   Stage IV Lip and Oral Cavity Squamous Cell Carcinoma
  Interventions:   Biological: Cetuximab;   Drug: Ficlatuzumab
  Sponsors:   University of Arizona;   National Cancer Institute (NCI)
  Recruiting
• Safety, Tolerability and Pharmacodynamic Activity of Sotagliflozin in Hemodynamically Stable Patients With Worsening Heart Failure

  NCT03292653

  Condition:   Cardiac Failure Aggravated
  Interventions:   Drug: Sotagliflozin (SAR439954);   Drug: Placebo;   Drug: Heavy Water;   Drug: 131-Iodine-Albumin
  Sponsor:   Sanofi
  Recruiting
• Pregnancy Outcome and Safety of Interrupting Therapy for Women With Endocrine Responsive Breast Cancer

  NCT02308085

  Condition:   Early Breast Cancer
  Intervention:   Other: Endocrine therapy interruption
  Sponsors:   International Breast Cancer Study Group;   Alliance for Clinical Trials in Oncology;   Canadian Cancer Trials Group;   Breast International Group
  Recruiting
• A Study of mRNA-5671/V941 as Monotherapy and in Combination With Pembrolizumab (V941-001)

  NCT03948763

  Conditions:   Neoplasms;   Carcinoma, Non-Small-Cell Lung;   Pancreatic Neoplasms;   Colorectal Neoplasms
  Interventions:   Biological: V941;   Biological: Pembrolizumab
  Sponsor:   Merck Sharp & Dohme Corp.
  Recruiting
• An Investigational Immunotherapy Study of BMS-986299 Alone and in Combination With Nivolumab and Ipilimumab in Participants With Solid Cancers That Have Spread or Cannot be Removed

  NCT03444753

  Condition:   Advanced Cancer
  Interventions:   Drug: BMS-986299;   Biological: Nivolumab;   Biological: Ipilimumab
  Sponsor:   Bristol-Myers Squibb
  Recruiting
• PF-06651600 for the Treatment of Alopecia Areata

  NCT03732807

  Condition:   Alopecia Areata
  Interventions:   Drug: PF-06651600 Induction Dose;   Drug: PF-06651600 Maintenance Dose #1;   Drug: PF-06651600 Maintenance Dose #2;   Drug: PF-06651600 Maintenance Dose #3;   Drug: Placebo
  Sponsor:   Pfizer
  Recruiting
• Derazantinib and Atezolizumab in Patients With Urothelial Cancer

  NCT04045613

  Condition:   Urothelial Carcinoma
  Interventions:   Drug: Derazantinib;   Drug: Atezolizumab (drug supplied by Hoffmann-La Roche)
  Sponsor:   Basilea Pharmaceutica
  Recruiting
• A Clinical Study of ANX005 and IVIG in Subjects With Guillain Barré Syndrome (GBS)

  NCT04035135

  Condition:   Guillain-Barré Syndrome
  Interventions:   Drug: ANX005;   Drug: Intravenous immunoglobulin
  Sponsors:   Annexon, Inc.;   ResearchPoint Global;   International Centre for Diarrhoeal Disease Research, Bangladesh
  Recruiting
• Study of Azeliragon in Patients With Mild Alzheimer's Disease and Impaired Glucose Tolerance

  NCT03980730

  Condition:   Alzheimer Disease
  Interventions:   Drug: Azeliragon;   Drug: Placebo
  Sponsor:   vTv Therapeutics
  Recruiting
• A Study To Evaluate Safety And Therapeutic Activity Of RO6874281 In Combination With Pembrolizumab, In Participants With Advanced Or Metastatic Melanoma

  NCT03875079

  Condition:   Metastatic Melanoma
  Interventions:   Drug: RO6874281;   Drug: Pembrolizumab
  Sponsor:   Hoffmann-La Roche
  Recruiting
• Safety and Efficacy of KY1044 and Atezolizumab in Advanced Cancer

  NCT03829501

  Conditions:   Squamous Cell Carcinoma of Head and Neck;   Non-small Cell Lung Cancer;   Hepatocellular Carcinoma;   Esophageal Cancer;   Gastric Cancer;   Melanoma;   Renal Cell Carcinoma;   Pancreatic Cancer;   Cervical Cancer;   Triple Negative Breast Cancer;   Advanced Cancer
  Interventions:   Drug: KY1044;   Drug: KY1044 and atezolizumab
  Sponsor:   Kymab Limited
  Recruiting
• Safety and Efficacy Study of Pemetrexed + Platinum Chemotherapy + Pembrolizumab (MK-3475) With or Without Lenvatinib (MK-7902/E7080) as First-line Intervention in Adults With Metastatic Nonsquamous Non-small Cell Lung Cancer (MK-7902-006/E7080-G000-315/LEAP-006)

  NCT03829319

  Condition:   Nonsquamous Non-small Cell Lung Cancer
  Interventions:   Biological: Pembrolizumab;   Drug: Carboplatin;   Drug: Cisplatin;   Drug: Pemetrexed;   Drug: Lenvatinib;   Drug: Placebo matching lenvatinib
  Sponsors:   Merck Sharp & Dohme Corp.;   Eisai Inc.
  Recruiting
• Study to Determine the Safety, Tolerability, Pharmacokinetics and RP2D of ABBV-151 as a Single Agent and in Combination With ABBV-181 in Subjects With Locally Advanced or Metastatic Solid Tumors

  NCT03821935

  Condition:   Advanced Solid Tumors Cancer
  Interventions:   Drug: ABBV-151;   Drug: ABBV-181
  Sponsor:   AbbVie
  Recruiting
• A Study of Tislelizumab (BGB-A317) in Combination With Chemotherapy as First Line Treatment in Patients With Advanced Esophageal Squamous Cell Carcinoma

  NCT03783442

  Condition:   Esophageal Squamous Cell Carcinoma (ESCC)
  Interventions:   Drug: Platinum (cisplatin or oxaliplatin) + Fluorouracil (5-FU);   Drug: Platinum (cisplatin or oxaliplatin) + capecitabine;   Drug: Platinum (cisplatin or oxaliplatin) + paclitaxel
  Sponsor:   BeiGene
  Recruiting
• A Study To Evaluate the Efficacy and Safety Of Atezolizumab or Placebo in Combination With Neoadjuvant Doxorubicin + Cyclophosphamide Followed By Paclitaxel + Trastuzumab + Pertuzumab In Early Her2-Positive Breast Cancer

  NCT03726879

  Condition:   Breast Cancer
  Interventions:   Drug: Atezolizumab;   Drug: Placebo;   Drug: Doxorubicin;   Drug: Cyclophosphamide;   Drug: Paclitaxel;   Drug: Trastuzumab;   Drug: Pertuzumab;   Drug: Trastuzumab Emtansine
  Sponsors:   Hoffmann-La Roche;   Chugai Pharmaceutical
  Recruiting
• A Study to Test Radium-223 With Docetaxel in Patients With Prostate Cancer

  NCT03574571

  Condition:   Prostate Cancer
  Interventions:   Drug: Docetaxel 75 mg/m2;   Drug: Docetaxel 60 mg/m2;   Drug: Radium-223
  Sponsors:   Memorial Sloan Kettering Cancer Center;   Bayer
  Recruiting
• A Study of ASP1948, Targeting an Immune Modulatory Receptor, in Subjects With Advanced Solid Tumors

  NCT03565445

  Condition:   Advanced Solid Tumors
  Interventions:   Drug: ASP1948;   Drug: nivolumab
  Sponsor:   Astellas Pharma Global Development, Inc.
  Recruiting
• Trientine Tetrahydrochloride (TETA 4HCL) for the Treatment of Wilson's Disease

  NCT03539952

  Condition:   Wilson Disease
  Interventions:   Drug: TETA 4HCL;   Drug: Penicillamine
  Sponsor:   GMP-Orphan SAS
  Recruiting
• A Phase I Study of BTRC4017A in Participants With Locally Advanced or Metastatic HER2-Expressing Cancers

  NCT03448042

  Condition:   Solid Tumors
  Intervention:   Drug: BTRC4017A
  Sponsor:   Genentech, Inc.
  Recruiting
• A Study Of Multiple Immunotherapy-Based Treatment Combinations In Participants With Metastatic Non-Small Cell Lung Cancer (Morpheus- Non-Small Cell Lung Cancer)

  NCT03337698

  Condition:   Carcinoma, Non-Small-Cell Lung
  Interventions:   Drug: Atezolizumab;   Drug: Cobimetinib;   Drug: RO6958688;   Drug: Docetaxel;   Drug: CPI-444;   Drug: Pemetrexed;   Drug: Carboplatin;   Drug: Gemcitabine;   Drug: Linagliptin;   Drug: Tocilizumab;   Drug: Ipatasertib;   Drug: Idasanutlin
  Sponsor:   Hoffmann-La Roche
  Recruiting
• AVID100 in Advanced Epithelial Carcinomas

  NCT03094169

  Conditions:   Solid Tumor, Adult;   Triple Negative Breast Cancer;   Head and Neck Squamous Cell Carcinoma;   Non Small Cell Lung Cancer
  Intervention:   Drug: AVID100 IV
  Sponsor:   Formation Biologics
  Recruiting
• A Study of the Safety and Tolerability of ABBV-621 in Participants With Previously Treated Solid Tumors and Hematologic Malignancies

  NCT03082209

  Conditions:   Advanced Solid Tumors Cancer;   Hematologic Malignancies
  Interventions:   Drug: ABBV-621;   Drug: Venetoclax;   Drug: Bevacizumab;   Drug: FOLFIRI
  Sponsor:   AbbVie
  Recruiting
• Trial on Efficacy and Safety of Pritelivir Tablets for Treatment of Acyclovir-resistant Mucocutaneous HSV (Herpes Simplex Virus) Infections in Immunocompromised Adults

  NCT03073967

  Condition:   HSV Infection
  Interventions:   Drug: Pritelivir;   Drug: Foscarnet
  Sponsors:   AiCuris Anti-infective Cures GmbH;   Medpace, Inc.
  Recruiting
• A Dose-finding Study of CC-90009 in Subjects With Relapsed or Refractory Acute Myeloid Leukemia or Relapsed or Refractory Higher-risk Myelodysplastic Syndromes

  NCT02848001

  Conditions:   Leukemia, Myeloid, Acute;   Myelodysplastic Syndromes
  Intervention:   Drug: CC-90009
  Sponsor:   Celgene
  Recruiting
• GZ/SAR402671 in Combination With Cerezyme in Adult Patients With Gaucher Disease Type 3

  NCT02843035

  Condition:   Gaucher Disease Type 1-Gaucher Disease Type 3
  Intervention:   Drug: GZ402671
  Sponsor:   Genzyme, a Sanofi Company
  Recruiting
• An Investigational Immuno-therapy Study of Experimental Medication BMS-986179 Given Alone and in Combination With Nivolumab

  NCT02754141

  Condition:   Malignant Solid Tumor
  Interventions:   Biological: BMS-986179;   Biological: Nivolumab;   Biological: rHuPH20
  Sponsor:   Bristol-Myers Squibb
  Recruiting
• DS-3201b in Participants With Lymphomas

  NCT02732275

  Conditions:   Lymphoma, Malignant;   Non-hodgkin Lymphoma
  Intervention:   Drug: DS-3201b
  Sponsors:   Daiichi Sankyo Co., Ltd.;   Daiichi Sankyo, Inc.
  Recruiting