Narcolepsy



Narcolepsy Protect Against Alzheimer's Disease?


Conditions:   Narcolepsy;   Amyloid Pathology
Intervention:   Device: PET-scan18F-AV-45
Sponsor:   University Hospital, Montpellier
Completed


Investigation of Clinical Feature and Brain Function in Narcoleptic Patients


Conditions:   Narcolepsy;   REM Sleep Behavior Disorder
Intervention:  
Sponsor:   Tang-Du Hospital
Recruiting


The Role of the Circadian System in Neurological Sleep-wake Disorders


Conditions:   Narcolepsy 1;   Idiopathic Hypersomnia
Interventions:   Behavioral: Sleep restriction;   Behavioral: Sleep deprivation
Sponsor:   Esther Werth
Recruiting


Phase 1 TAK-925 Study in Healthy Adult and Elderly Volunteers and Patients With Narcolepsy


Condition:   Healthy Participants and Patients With Narcolepsy
Interventions:   Drug: TAK-925;   Drug: Placebo
Sponsor:   Takeda
Recruiting


A Study to Evaluate the Safety and Efficacy of TS-091 in Patients With Narcolepsy


Condition:   Narcolepsy
Interventions:   Drug: TS-091 5mg;   Drug: TS-091 10mg;   Drug: Placebo
Sponsor:   Taisho Pharmaceutical Co., Ltd.
Recruiting


Evaluation of Academic and Professional Trajectories of Narcoleptic Patients


Condition:   Narcolepsy
Intervention:   Other: Questionnaires
Sponsor:   Hospices Civils de Lyon
Not yet recruiting


A Study of the Efficacy and Safety of JZP-258 in Subjects With Narcolepsy With Cataplexy


Condition:   Narcolepsy With Cataplexy
Interventions:   Drug: JZP-258;   Other: Placebo
Sponsor:   Jazz Pharmaceuticals
Recruiting


Cardiovascular Variability and Heart Rate Arousal Response in Idiopathic Hypersomnia


Conditions:   Narcolepsy;   Cataplexy
Intervention:   Device: Polysomnography
Sponsor:   Centre Hospitalier Universitaire de Saint Etienne
Completed


The Effect of Caffeine on the Narcoleptic Patients


Condition:   Narcolepsy
Interventions:   Drug: Vivarin;   Drug: Fiber
Sponsors:   King Saud University;   King Saud Medical City
Recruiting


Safety and Efficacy of THN102 on Sleepiness in Narcoleptic Patients


Condition:   Narcolepsy
Interventions:   Drug: THN102 300/3;   Drug: THN102 300/27;   Drug: Modafinil 300
Sponsor:   Theranexus
Recruiting


Sodium Oxybate for Treatment of Excessive Daytime Sleepiness and Cataplexy in Narcolepsy


Conditions:   Excessive Daytime Sleepiness;   Cataplexy;   Narcolepsy
Interventions:   Drug: Sodium Oxybate;   Drug: Placebo
Sponsor:   Flamel Ireland Limited
Recruiting


Xyrem and Brain Dopamine in Narcolepsy


Condition:   Narcolepsy With Cataplexy
Intervention:   Drug: Xyrem
Sponsor:   Centre for Addiction and Mental Health
Recruiting


Efficacy and Safety of Pitolisant in Pediatric Narcoleptic Patients With or Without Cataplexy, Double-blind Study Followed by a Prolonged Open-label Period


Conditions:   Narcolepsy With Cataplexy;   Narcolepsy Without Cataplexy
Interventions:   Drug: pitolisant;   Drug: Placebo
Sponsor:   Bioprojet
Recruiting


A Study of Safety and Efficacy of BTD-001 in Treatment of Patients With Idiopathic Hypersomnia (IH) or Narcolepsy Type 2


Conditions:   Idiopathic Hypersomnia;   Narcolepsy Without Cataplexy
Interventions:   Drug: BTD-001;   Drug: Placebo
Sponsor:   Balance Therapeutics
Active, not recruiting


"Twelve-week Study of the Safety and Efficacy of JZP-110 in the Treatment of Excessive Sleepiness in Narcolepsy"


Condition:   Narcolepsy
Intervention:   Drug: JZP-110
Sponsor:   Jazz Pharmaceuticals
Completed


"A Long-Term Safety Study of JZP-110 in the Treatment of Excessive Sleepiness in Subjects With Narcolepsy or OSA"


Conditions:   Narcolepsy;   Obstructive Sleep Apnea
Intervention:   Drug: JZP-110
Sponsor:   Jazz Pharmaceuticals
Completed


A Multicenter Study of the Efficacy and Safety of Xyrem With an Open- Label Pharmacokinetic Evaluation and Safety Extension in Pediatric Subjects With Narcolepsy With Cataplexy


Condition:   Narcolepsy With Cataplexy
Intervention:   Drug: Xyrem
Sponsor:   Jazz Pharmaceuticals
Active, not recruiting


The Nuvigil and Provigil Pregnancy Registry


Conditions:   Narcolepsy;   Obstructive Sleep Apnea;   Shift Work Sleep Disorder
Intervention:   Drug: Modafinil/armodafinil
Sponsors:   Teva Pharmaceutical Industries, Ltd.;   United BioSource Corporation
Recruiting


Effects of BF2.649 in the Treatment of Excessive Daytime Sleepiness in Narcolepsy.


Condition:   Treatment of Excessive Daytime Sleepiness in Narcolepsy
Interventions:   Drug: BF2.649;   Drug: Vigil;   Drug: palcebo
Sponsor:   Bioprojet
Completed


Long Term Open Label Study in Narcolepsy With BF2.649 (Pitolisant)


Conditions:   Narcolepsy;   Cataplexy
Intervention:   Drug: BF2.649
Sponsor:   Bioprojet
Completed


Flumazenil for the Treatment of Primary Hypersomnia


Conditions:   Hypersomnia;   Primary Hypersomnia;   Idiopathic Hypersomnia;   Narcolepsy Without Cataplexy
Intervention:   Drug: Flumazenil
Sponsors:   Lynn Marie Trotti;   Georgia Research Alliance
Completed


Clarithromycin for the Treatment of Hypersomnia


Conditions:   Hypersomnia;   Idiopathic Hypersomnia;   Narcolepsy
Interventions:   Drug: Clarithromycin followed by placebo;   Drug: Placebo then Clarithromycin
Sponsor:   Lynn Marie Trotti
Completed


Effectiveness Of The Drug GSK189254 In Treating Patients With Narcolepsy


Condition:   Narcolepsy
Intervention:   Drug: GSK189254
Sponsor:   GlaxoSmithKline
Terminated


Body Weight Regulation in Patients With Narcolepsy


Condition:   Narcolepsy
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Completed


Sleep Disorders of Patients With Diseases of the Nervous System


Conditions:   Hypersomnia;   Narcolepsy;   Nervous System Disease;   Sleep Disorder
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

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