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Eczema (Atopic dermatitis)


General Purpose:

The term eczema is used to refer to chronically itchy, inflamed areas on the skin. Eczema often occurs alongside asthma or hay fever (allergic rhinitis). Although it typically occurs on the arms and behind the knees, eczema can occur on any location of the body. The normal course of eczema is one that gradually flares and subsides in a somewhat cyclical manner. Its cause is unknown, but heredity and immunity are believed by most experts to be likely involved in its onset.

Eczema causes red and/or brown patches to develop on the skin, as well as severe itching. It may also lead to the formation of small red bumps that can leak fluid onto the skin. Individuals who suffer from eczema often have thick, cracked, or scaly-appearing skin, which frequently becomes raw due to constant scratching.

Complications associated with severe eczema include skin infections as well as permanent eye damage. Due to its cosmetic and health-related implications, individuals with eczema may seek out clinical trials in order to find new ways of treating their condition when other methods have failed. Fortunately, there is a considerable amount of research currently being conducted with the purpose of helping to discover new and more effective eczema treatments.

What Will Eczema Clinical Trials Be like?

The types of procedures used in eczema clinical trials will ultimately depend on the specific nature of the study and what aspect of eczema is being studied. Provided below is a list of common procedures, tests, and assessments that may be incorporated into eczema clinical trials:

  • Detailed physical examination
  • A questionnaire or face-to-face interview to provide details related to your history of eczema, which may include questions related to the following:
    • Date you first developed eczema
    • Noticeable triggers
    • Use of cosmetic and personal hygiene products
    • Family history of eczema
    • Use of prescription or over-the-counter medications, including vitamins, minerals, and other dietary supplements.
    • Treatments you have attempted to use for your eczema.
    • You may also be asked to avoid wearing lotions, perfumes, colognes, or scented make-up on the day(s) of your appointment.
    • Questionnaires to evaluate your stress level and/or emotional well-being.
    • Blood tests
    • Skin biopsy
    • Dietary logs
    • Photographs of your skin
    • Use of lotions, creams, oral medications, or laser light therapy.

Typical Eczema Clinical Trial Protocol:

Specific examples of clinical trials for eczema might include the following:

  • A randomized trial comparing two different concentrations of a new prescription cream designed to treat eczema. This trial would require participants to apply a topical lotion or solution to their eczema patches two to three times a day over a 12 week period. Participants would be observed at regular three-week intervals to document any changes in the appearance and itchiness of their patches, and have photographs taken of their skin to document progress. At the conclusion of the study, the two groups would be compared to determine if one particular concentration of the cream was more effective than the other.
  • A study to determine if specific dietary changes (e.g., elimination of dairy, increased intake of fiber) are effective at reducing eczema flare-ups in individuals with a family history of eczema as well as an underlying diagnosis of asthma.
  • A study designed to determine if the use of a newly-developed laser therapy is effective and safe for treating eczema in children.
  • A randomized clinical trial in which individuals with eczema are randomly assigned to receive treatment with a newly-developed skin patch designed to deliver medication directly to eczema patches, or to receive a placebo patch.

A brief word about randomized trials and placebos:

Many clinical trials involve the comparison of an investigational treatment to a “standard” treatment. Some studies determine which therapy a patient receives through a process known as randomization, in which patients are randomly assigned to receive either the investigational treatment or the standard treatment.

On occasion, a trial will investigate the use of a standard treatment plus a new drug compared to standard treatment plus a placebo. Placebos are inactive or “sham” treatments that are identical in appearance to the active treatment but have no therapeutic value.

Placebos are necessary to help determine if adverse effects that occur during the clinical trial are the result of the investigational treatment or due to some other factor. They also allow researchers to measure the effects of the active treatment and observe what would have happened without it.

In rare instances where no standard therapy exists, or when a new drug or therapy is being investigated (such as the fourth clinical trial example described above), the investigational treatment might be compared to a placebo alone. In these types of trials, those patients who are randomized to the placebo group do not receive an active treatment.

It is important to know that placebo-only trials are only conducted when scientifically necessary and when patients have been adequately informed that they may end up receiving the placebo rather than the active treatment. It is very important to note, however, that no one should ever participate in such a placebo trial when there is a widely available and highly effective standard treatment already in existence for their particular disease or condition.

Trial Eligibility and Medical Information Needed:

The type of clinical trial you may be eligible for often depends on many factors. Therefore, it is important to know as many details as possible with regard to your specific circumstances when searching for clinical trials.  Examples of information you may want to have on hand include the following:

  • Your history of treatment for eczema
  • Your prior and current diagnoses of any other health conditions or diseases
  • Your current medications (including vitamins, minerals, and other dietary supplements)

Suggested Search Terms:

 “eczema treatment,” “eczema children,” “eczema diet,” “eczema complications,” “eczema scar,” “eczema eyes,” “eczema infection,” “eczema allergies,” “eczema asthma,” “eczema food,” and “eczema infants.” 

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A Study of Baricitinib (LY3009104) in Adult Participants With Moderate to Severe Atopic Dermatitis

Condition:   Atopic Dermatitis
Interventions:   Drug: Baricitinib;   Drug: Placebo
Sponsors:   Eli Lilly and Company;   Incyte Corporation
Not yet recruiting

Efficacy and Safety of Fucicort® Lipid Cream Compared to Combination Treatment With Fucidin® Cream Followed by Betamethasone (Lianbang Beisong®) Cream and Fucicort® Lipid Cream Vehicle in Clinically Infected Atopic Dermatitis/Eczema

Condition:   Infected Atopic Dermatitis/Eczema
Interventions:   Drug: Fucicort® Lipid cream;   Drug: Fucidin® cream;   Drug: Fucicort® Lipid cream vehicle;   Drug: betamethasone (Lianbang Beisong®) cream
Sponsor:   LEO Pharma
Not yet recruiting

8-Week Atopic Dermatitis (AD) Treatment Study

Condition:   Atopic Dermatitis Eczema
Interventions:   Drug: Investigational OTC Cream;   Drug: 0.05% Desonide;   Other: Placebo Cream
Sponsor:   Procter and Gamble

EARLYEMOLLIENT - Feasibility of Early Emollient Use in Children With Atopic Eczema

Condition:   Atopic Dermatitis
Intervention:   Other: LIPIKAR BAUME AP+ emollient
Sponsors:   University of Schleswig-Holstein;   Technische Universität Dresden

A Study of Long-term Baricitinib (LY3009104) Therapy in Atopic Dermatitis

Condition:   Atopic Dermatitis
Interventions:   Drug: Baricitinib;   Drug: Placebo
Sponsors:   Eli Lilly and Company;   Incyte Corporation
Not yet recruiting

Study of Baricitinib (LY3009104) in Adults With Moderate to Severe Atopic Dermatitis

Condition:   Atopic Dermatitis
Interventions:   Drug: Baricitinib;   Drug: Placebo
Sponsors:   Eli Lilly and Company;   Incyte Corporation

Immunogenetic Profiling of Dupilumab for the Treatment of Atopic Dermatitis

Conditions:   Atopic Dermatitis;   Atopic Dermatitis Eczema
Intervention:   Drug: Dupilumab
Sponsors:   University of California, San Francisco;   Regeneron Pharmaceuticals
Not yet recruiting

Softened Water for Eczema Prevention Pilot Trial

Condition:   Atopic Eczema
Intervention:   Device: Domestic ion-exchange water softener
Sponsors:   King's College London;   Guy's and St Thomas' NHS Foundation Trust;   University of Nottingham;   University of Sheffield;   Imperial College London;   University of Amsterdam;   University of Dundee
Not yet recruiting

Microbial Colonization and Change of Chronic Keratinized Hand Eczema After Using Halometasone Triclosan

Condition:   Chronic Hand Eczema
Intervention:   Drug: Halometasone Triclosan
Sponsor:   Beijing Friendship Hospital

A Longitudinal Investigation of Skin Barrier Development From Birth and the Validation of Early Predictors of Atopic Eczema Risk: the Skin Testing for Atopic Eczema Risk (STAR) Study

Condition:   Atopic Eczema
Intervention:   Diagnostic Test: Skin Testing for Atopic eczema
Sponsors:   Sheffield Teaching Hospitals NHS Foundation Trust;   University of Sheffield

Study to Evaluate the Efficacy and Safety of ZL-3101 in Subjects With Subacute Eczema

Condition:   Eczema
Interventions:   Drug: ZL-3101;   Drug: Placebo
Sponsor:   Zai Lab Pty. Ltd.

Etiology of Eczema Herpeticum (EH)

Condition:   Eczema Herpeticum
Sponsors:   National Institute of Allergy and Infectious Diseases (NIAID);   Atopic Dermatitis Research Network

Alitretinoin vs Cyclosporine in Severe Recurrent Vesicular Hand Eczema

Condition:   Hand Eczema
Interventions:   Drug: Alitretinoin;   Drug: cyclosporin A
Sponsors:   University Medical Center Groningen;   ZonMw: The Netherlands Organisation for Health Research and Development

Black Tea Compresses for Facial Eczema and Perioral Dermatitis

Condition:   Eczema, Dermatitis
Intervention:   Other: Black tea compress treatment
Sponsor:   University of Luebeck

Narrowband Ultraviolet B Versus Narrowband Ultraviolet B Plus Ultraviolet A1 for Atopic Eczema

Condition:   Atopic Eczema
Intervention:   Radiation: combined ultraviolet phototherapy (NB-UVB + UVA1) vs. NB-UVB monotherapy
Sponsors:   University of Dundee;   NHS Tayside

A Trial of a Botanical Drug Containing East Indian Sandalwood Oil (EISO) For Treatment of Atopic Dermatitis

Conditions:   Atopic Dermatitis;   Eczema
Interventions:   Drug: SAN007 5% cream;   Drug: Placebo;   Drug: SAN007 10% cream
Sponsors:   Santalis Pharmaceuticals, Inc.;   ClinDatrix, Inc.;   Texas Dermatology and Laser Specialists;   Clinical Trials of Texas, Inc;   DermResearch, Inc;   Progressive Clinical Research

Trial to Determine the Therapeutic Benefit of an OTC Cream on Dry, Itchy Skin of Adults and Children With Eczema

Condition:   Atopic Dermatitis
Interventions:   Device: EpiCeram Skin Barrier Emulsion;   Drug: Experimental Product 1% Colloidal Oatmeal Balm
Sponsor:   Johnson & Johnson Consumer Inc. (J&JCI)

Proof of Concept, Twice Daily Applications of LEO 124249 Ointment in the Treatment of Chronic Hand Eczema

Condition:   Hand Eczema
Interventions:   Drug: LEO 124249 ointment;   Drug: LEO 124249 ointment vehicle
Sponsor:   LEO Pharma

Study to Examine the Benefits of Fabric Made With Lyocell/Chitosan/Ceramide in the Treatment of Children With Mild to Moderate Eczema

Condition:   Atopic Dermatitis
Interventions:   Device: Non-medicated Emollient plus Lyocell/Chitosan Sleeve;   Other: Non-medicated Emollient plus Cotton Sleeve;   Other: Placebo Sleeve
Sponsor:   University of Minnesota - Clinical and Translational Science Institute

Clinical Study to Assess the Efficacy and Safety of DF277 Compared to Placebo in the Treatment of Otic Eczema

Condition:   Otic Eczema
Interventions:   Drug: DF277;   Drug: Placebo
Sponsor:   Salvat

Defining the Skin and Blood Biomarkers of Pediatric Atopic Dermatitis

Conditions:   Atopic Dermatitis;   Eczema
Sponsors:   Northwestern University;   Rockefeller University

Randomised, Double-blind, Placebo-controlled Study of Topical Clobetasone Butyrate 0.05% Cream in Subjects With Eczema for Two Weeks to Evaluate the Efficacy and Safety

Condition:   Eczema
Interventions:   Drug: Clobetasone Butyrate 0.05% Cream;   Drug: Vehicle (base cream)
Sponsor:   GlaxoSmithKline

Reversal of Epidermal Phenotype in Severe Atopic Dermatitis With Cyclosporine Therapy

Conditions:   Atopic Dermatitis;   Eczema
Intervention:   Drug: Cyclosporine A
Sponsor:   Rockefeller University

Efficacy and Safety of a Retinoid in the Treatment of Severe Chronic Hand Eczema

Condition:   Eczema
Interventions:   Drug: alitretinoin;   Drug: Placebo
Sponsors:   Stiefel, a GSK Company;   Basilea Pharmaceutica

Dandelion Juice in the Treatment of Dyshidrotic Hand Eczema

Conditions:   Vesicular Palmoplantar Eczema;   Pompholyx
Intervention:   Drug: dandelion juice
Sponsor:   Odense University Hospital

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