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Better, Faster TB TreatmentResults of a recent TB clinical study suggests a faster, more effective drug treatment for tuberculosis is very close to realization.

A Phase II clinical trial study, published in the UK journal The Lancet, and conducted in South Africa, demonstrated an effective new combination of drugs that killed more than 99 percent of the patient’s tuberculosis bacteria within two weeks. The speed and effectiveness suggest the new regimen could improve upon existing TB treatments for not only general TB, but also drug resistant and TB/HIV co-infected patients.

Historically tuberculosis (often shortened to TB for tubercle bacillus) was a major killer that, while never eradicated, by the 1950’s seemed to be less of a health threat. Modern antibiotic TB treatments and health practices generally reduced the incidence of tuberculosis to the status of a minor disease.

That changed during the 1980s, as strains of TB appeared that were resistant to traditional antibiotics. By the 1990s, the World Health Organization again labeled TB a global health emergency.   [continue reading…]


Fighting Ovarian CancerThe American Cancer Society estimates that 22,280 women in the US will be diagnosed with Ovarian Cancer, and 15,500 of those cases will be fatal. To raise awareness of ovarian cancer, we interviewed Dee, author of the blog Women of Teal. She is an ovarian cancer survivor, fighter, and advocate. She kindly shared her story and clinical trial experiences with JCT.

I am a wife and mother. After working as an engineer teaching us soda pdf editors, college program coordinator, and computer teacher I did not think the focus of my life would change yet again. But in 2005, after being diagnosed with Ovarian Cancer I became a cancer survivor and research advocate.

I attended the Lance Armstrong Foundation’s Survivor Summits, became a member of my state’s Cancer Control Plan workgroup and joined a number of ovarian cancer advocacy organizations, serving on the Board of the Kaleidoscope of Hope Foundation for three years. In 2007, I began writing my blog, Women of Teal, in order to share what I have learned on this journey with others and to raise awareness of the disease, its treatments and the need for more research.

1. Would you please share with our readers how you were first diagnosed with ovarian cancer, and at what stage it was at?

I visited The Center for Cosmetic & Reconstructive Gynecology, my gynecologist for my annual exam and mentioned to her an odd pain I was having on my left side. I thought I might have just pulled a muscle. She thought we should investigate further and sent me for a transvaginal ultrasound.

The day after I had the ultrasound I was in the ER in terrible pain. The ER physician contacted the radiologist and gynecologist des moines ia, and I was scheduled the next day for an MRI. [continue reading…]


Stress Illness: Its More Common Than You Think

Stress IllnessStress illness, otherwise known as Psychophysiologic Disorder or PPD, may not be a household word, but the conditions that result from it are all too common. We feature a leading expert in the field of PPD, Dr. David D. Clarke, in our JCT interview series. He was kind enough to shed some light on what PPD is and how it affects an estimated five to ten million people in the United States. You can visit breast augmentation procedures in Michigan area when you want the best surgery done for you.

Dr. Clarke is the President of the Psychophysiologic Disorders Association (PPDA) in the U.S., and his biography and stellar qualifications follow the interview.

Dr. Clarke, could you please define the term “Stress Illness?”

The term “stress illness” describes an illness that is not linked to any disease of an organ or structure in the body, but one that diagnostic tests can’t explain. Often, people have physical symptoms that cause them discomfort or pain, but tests run by their doctor don’t show a cause for the symptoms. Do you know that gardening can somehow relieve people’s stress? If you know someone who’s suffering from this condition, they can focus their attention on gardening. Visit this website nbglandscapes.com.au to read some tips for designing your landscape.

Most of these patients are actually suffering from symptoms and illness caused by stress, which can be unrecognized or not readily apparent, hence the term “stress illness”, otherwise known as PPD.

How does it differ from the regular stress we experience every day?

Everyone experiences stress, but there are two main differences between regular stress and stress illness. To lessen your stress on your baby’s heartbeat you can use baby heartbeat monitor and feel secured. For a stress-free dental care for your teeth just go to headaches and tooth decay. The first is the degree and high level of stress which is producing physical symptoms such as stomach upset, headaches, and body pain on a regular basis. The second is that the person is not aware of the magnitude of the stress they are coping with because they have been living with it consistently. [continue reading…]


Type 2 Diabetes TreatmentA new drug, Trajenta, has been proven to work for type 2 cultural diabetes treatment programs after a lengthy but successful clinical trial process.

An extended clinical trial of the drug linagliptin (Trajenta), conducted for a group of over 2,000 patients from 32 countries with type 2 diabetes, confirmed the drug as safe and effective for lowering and maintaining blood sugar levels for up to 102 weeks.

Fundamentally, all forms of diabetes are a condition where a person has high blood sugar, which means there’s too much sugar (glucose) in the blood for the body to process normally. The effects of this condition begin with the three classic symptoms of hyperglycemia, frequent urination, increased thirst, and increased hunger.

If untreated, diabetes can produce many serious long-term complications including cardiovascular disease (heart disease), kidney disease (renal failure), damage to the eyes (retinopathy) where you should go and get Eye exams, damage to the nerves (neuropathy) and in severe incidents, diabetic coma.

With modern type 2 diabetes treatment, diabetes is rarely fatal in its own right, but it is a major contributor to many other illnesses, many of which are fatal.

The key component in diabetes is insulin. Insulin is a hormone produced by the pancreas and its job is to regulate the blood sugar level of the body. In a way it acts like a stimulant to the liver, muscle and fat tissue to take glucose (blood sugar) from the blood and either metabolize (use) it or store it as fat. Lack or failure of insulin to do this job is the cause of diabetes.

Of the three major types of diabetes, type 2 is by far the most common – and becoming more common in the every part of the world where poor diet and health habits are the norm. Unlike type 1 diabetes, where there is little or no production of insulin, doctors characterize type 2 diabetes by sometimes-low insulin production and almost always a reduced sensitivity to insulin.

That is, various organs, notably the liver and muscles, no longer respond to insulin normally. They fail to either metabolize or store the glucose, which results in an increased glucose level in the blood.

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Anti-Vaccination? Vaccines save 3 million lives per year, and are proven to be safe, so why have whooping cough and other viruses made a comeback? Still Anti-Vaccination groups continue to resist giving their children the vaccines that doctors recommend. It is important to note that doctors can be hesitant to prescribe Dianette, largely because it is associated with a higher risk of blood clots and certain types of cancer. For this reason, your doctor will never prescribe you Dianette if you only need it for contraception or you can get this prescription drug online at https://www.ukmeds.co.uk/treatments/contraceptive-pill/dianette/.

Well over two hundred years ago, doctors began to put mysterious fluids into people’s bodies by means of injecting it through a long needle stuck in the arm, rump or other tender body part. They called the procedure vaccination and said its promise was to prevent not only individuals but also whole populations from contracting scourge diseases such as smallpox, whooping cough and polio.

Decades, even centuries later, the results continue. The promises were kept. Killer diseases such as smallpox, whooping cough and polio virtually disappeared while playing casino guides. Today, vaccination programs in every country of the world inoculate several hundred million children against ten to twenty serious diseases.

Research labs continue to search for new vaccinations to prevent other major infectious diseases such as malaria, tuberculosis and HIV/AIDS. Every year some of their work goes to clinical trial.

The evidence for the effectiveness of vaccinations isn’t just convincing; its two hundred years deep, billions of people strong, and the saving of countless millions of lives.

And yet, in some parts of the world, even in developed countries, and especially in the United States, there is a loud and influential anti-vaccine movement. By now, the controversies are widely known. Much of it began with the charge that vaccines for measles caused autism. A recent survey indicates that even after years of debunking the charge, 20% of Americans believe vaccines cause autism. [continue reading…]


How does UV light causes cancer?According to Diane Walder, MD, 90% of skin cancers are linked to UV light from the sun, but discovering how UV light causes cancer is the key to new treatments.

All cancers are bad, but melanomas, loosely known as skin cancers, are among the worst. In fact, only three percent of skin cancers are melanoma, but they account for more than 75% of skin cancer deaths.  If caught early, melanoma is usually highly treatable. Caught late, after it metastasizes, it is usually fatal. If you want to start taking care of your skin, we suggest to start using the pore vacuum.

Doctors have known for decades there is a link between exposure to the sun, specifically ultraviolet (UV) light, and melanoma. You may have heard about not getting too much sun, using sun-blocker to protect your skin and avoid spending much time in a tanning booth and assist to a Skin Care in Phoenix to check and treat your skin in case of damage.

The big question for research and a potential step for better melanoma treatment or even a cure was how does UV light cause the cancer?

The key to the approach taken by researchers at the Broad Institute of M.I.T. and Harvard (USA) and the University of Texas MD Anderson Cancer Center, builds upon the knowledge that melanoma tumors are full of cells with genetic damage caused by UV exposure, mostly caused by sunlight.

As with many cancers, genetic mutations often link to the uncontrolled growth of cancer cells. The question with melanoma is which mutations drive this cancer? [continue reading…]


Low-Glycemic Index Diet While comparing and researching diets, researchers concluded the best diet for most people is the Low-Glycemic Index Diet. Why? Because as a unit of measurement, all calories are equal. As a specific type of food – as far as the human body is concerned – calories are NOT equal. That’s the conclusion of a new study published in the New England Journal of Medicine (June 27, 2012) conducted by researchers at Boston Children’s Hospital (USA).

In the ongoing search (it’s tempting to say, desperate search) for truly effective weight loss diets, the new study puts figures to something that many nutritionists and doctors have said for some time: cutting down on carbohydrates and glucose (sugars, also a carbohydrate) is preferable to cutting down on fats.

The study goes further by saying that a low glycemic index (blood sugar level) diet has similar benefits to low-carb diets but without the risk of stress and inflammation that very low-carbohydrate intake may cause.

In very simple terms, the study is recommending that people eat less sugary foods as the primary way to lose weight on a permanent basis. The study is also saying that eating the same number of calories in fat as in carbohydrates will cause the body to burn 300 fewer calories. Another way of staying fit and healthy is to choose the food or products that you will eat and you can find it via 7supplements.com. To the body, not all calories are the same. For example, if you are trying to lose weight while building muscle, there are best fruits for building muscle mass. [continue reading…]


New Treatment Anakinra (IL-1Ra)Strokes caused by clots or blood vessel breaks in the brain are the third most common cause of death. They are also the leading cause of disability. For decades, researchers have worked to find drugs or other methods that can reduce the damage caused by strokes – post stroke treatment – especially to combat often life-changing disabilities.

Lead researchers Dame Nancy Rothwell, Stuart Allan of Manchester University (UK), and their team investigated such treatments for over twenty years. They believe they have found one that works. After a Phase II clinical trial with a small number of patients, the drug Anakinra (IL-1Ra) demonstrated a remarkable ability to reduce damage to the brain following a stroke.

Anakinra (IL-1Ra) is already in use – as a treatment for rheumatoid arthritis. How did the researchers get from arthritis to treatment of stroke?

The link is inflammation. One of the principle symptoms of rheumatoid arthritis is inflammation in and around joints, and Anakinra (IL-1Ra) is a drug used to reduce the inflammation.

In a very different context, when a stroke occurs, white blood cells, the body’s rapid response system, rush into the affected areas. In most other places in the body this is normal and a very good thing, but not in the brain.

The white blood cells cause inflammation, swelling and the death of brain cells (neurons). This is a principle cause of the severe and growing damage to brain systems following a Anakinra: New Treatment to Reduce the Damage of Strokesstroke. Because of the inflammation associated with strokes, the researchers reasoned that Anakinra (IL-1Ra)might be effective.

Because of the inflammation associated with strokes, the researchers reasoned that Anakinra (IL-1Ra) might be effective. Their initial experiments used rats (lab rats, of course). They created a special trial that included normal healthy rats and rats raised with stroke risk factors such as obesity, insulin resistance and atherosclerosis. Inducing a stroke in the rats, the researchers administered the drug ‘blind,’ not knowing which rats received the drug or the placebo, similar to human clinical trials. [continue reading…]


RDA for Vitamin CExperts considering raising the RDA for vitamin C can’t agree if the change will produce enough health benefits.The amounts of vitamin C needed by humans to prevent diseases and improve heath is still a matter of controversy among doctors and researches.

According to Weight Watchers, (https://www.groupon.com/coupons/stores/weightwatchers.com), the recommended dietary allowance of vitamin C is less than half of what it should be. So say researchers from Oregon State University (Corvallis, USA) in a recent report published in Critical Reviews in Food Science and Nutrition.

How much is enough? This is a question, or ongoing argument, for most vitamins. In the United States, as in most countries, a body of experts (the National Academy of Sciences in the U.S.) set what they consider an appropriate daily intake of a vitamin.

In the U.S., it’s called the Recommended Dietary Allowance, or RDA. For vitamin C, the RDA is currently 90 milligrams per day for an adult male (75 mg/day for adult female). Not enough, by a long shot, says the Oregon report, which documents the case for raising the RDA to 200 milligrams for an optimum level of benefit. [continue reading…]


JCT is pleased to introduce esteemed cancer specialist Dr. Tomasz Beer, and Dr. Larry Axmaker, author and prostate cancer survivor. They were kind enough to answer some questions about their experiences with cancer and clinical trials, from both a doctor’s and a patient’s perspective.


1. How did the two of you become colleagues/friends and what was the inspiration behind your blog? 

We met in the prostate cancer clinic as patient and physician and forged a friendship over the years.  The blog, along with the book was inspired by a strong desire to share knowledge about clinical trials with people who are living with cancer and who are called upon to make decisions about their cancer care. 


 2.  You are co-authors of the book Cancer Clinical Trials. Please tell us about it and what prompted you to write a book about clinical trials?

For 15 years now I have been deeply involved in clinical trials.  I have talked to thousands of cancer patients about hundreds of clinical trials.  Despite the fact that we spend a lot of time with each potential participant, I frequently had the nagging feeling that in the course of a clinic visit, or even several, we could never quite do a good enough job sharing all the knowledge I wanted to share with my patients.  The book was the only way to get this done. [continue reading…]


 Treatment for Alzheimer’sNew treatments for Alzheimer’s hinge on the success of three clinical trial drugs, which may not work, or may be too expensive to produce for the general population.

It would be very unusual not to know someone with Alzheimer’s disease or another form of dementia. One in eight older Americans develops dementia and it strikes most families. It is the sixth-leading cause of death in the United States.

The destruction of a person’s mental capacities – forgetfulness, disorientation, mood swings, loss of judgment – a whole raft of symptoms that often appear gradually over many years, makes dementia and Alzheimer’s among the most feared of all diseases.

Given its prominence, it’s obvious why medical research tackled the dementia related diseases many decades ago. Since then, science has learned a great deal, researchers have developed drug treatments, and the medical community along with the public now recognizes the nature and impact of the diseases.  [continue reading…]


Clinical Trials for TruvadaThe HIV preventative drug Truvada joins other HIV treatments already in use, but questions persist about its use, cost, and effectiveness.

There are very few of the proverbial ‘silver bullets’ in medicine – the one shot cure or the perfect vaccine. In fact, most serious diseases such as cancer, heart disease and HIV are complicated. There is no ‘cure’ or blanket preventative, much less a silver bullet. A good case in point is in the approval by the United State Food and Drug Administration (FDA) of the drug Truvada as an HIV preventative.

Note the word preventative, as in a drug taken to prevent getting HIV, something like a vaccine only in this case Truvada is a pill taken every day. Researchers introduced drugs to treat HIV in the early 1990’s, but Truvada is the first preventative, part of a program known as a pre-exposure prophylaxis, or PrEP. Considering that there are yearly about 50,000 new HIV cases in the United States alone, it would seem that preventing HIV (and the potential for Aids) ought to be a winning proposition. [continue reading…]