Amyotrophic Lateral Sclerosis (ALS)



Safety and Tolerability of High Dose Biotin in Patients With Amyotrophic Lateral Sclerosis


Condition:   Amyotrophic Lateral Sclerosis
Interventions:   Drug: Biotin;   Drug: Placebo Oral Tablet
Sponsor:   American University of Beirut Medical Center
Active, not recruiting


Optic Coherence Tomography in Patients With Amyotrophic Lateral Sclerosis


Condition:   Amyotrophic Lateral Sclerosis
Interventions:   Diagnostic Test: Optic coherence tomography;   Diagnostic Test: Pulmonary function test
Sponsor:   American University of Beirut Medical Center
Not yet recruiting


Safety and Tolerability of Perampanel in Amyotrophic Lateral Sclerosis Patients


Condition:   Amyotrophic Lateral Sclerosis
Intervention:   Drug: Fycompa
Sponsor:   American University of Beirut Medical Center
Recruiting


Resting Energy Expenditure Equations in Amyotrophic Lateral Sclerosis, Creation of a ALS-specific Equation


Condition:   Amyotrophic Lateral Sclerosis
Intervention:   Other: nutritional assessement
Sponsor:   University Hospital, Limoges
Completed


Epidemiology and Genetics of the Amyotrophic Lateral Sclerosis in the French West Indies


Condition:   Amyotrophic Lateral Sclerosis
Intervention:   Dietary Supplement: Blood sample and environmental survey
Sponsor:   Centre Hospitalier Universitaire de Pointe-a-Pitre
Recruiting


Blood-Brain Barrier Opening Using MR-Guided Focused Ultrasound in Patients With Amyotrophic Lateral Sclerosis


Condition:   Amyotrophic Lateral Sclerosis
Intervention:   Device: Blood-Brain Barrier opening with MRgFUS
Sponsor:   InSightec
Not yet recruiting


Rehabilitative Trial With tDCS in Amyotrophic Lateral Sclerosis


Condition:   Amyotrophic Lateral Sclerosis
Interventions:   Device: Anodal bilateral motor cortex and cathodal spinal tDCS;   Device: Sham bilateral motor cortex and sham spinal tDCS
Sponsor:   Azienda Ospedaliera Spedali Civili di Brescia
Recruiting


Conservative Iron Chelation as a Disease-modifying Strategy in Amyotrophic Lateral Sclerosis


Condition:   Amyotrophic Lateral Sclerosis
Interventions:   Drug: Deferiprone;   Drug: Placebo Oral Tablet
Sponsors:   University Hospital, Lille;   Ministry of Health, France
Not yet recruiting


Safety of Urate Elevation in Amyotrophic Lateral Sclerosis (ALS)


Condition:   Amyotrophic Lateral Sclerosis
Interventions:   Drug: Inosine;   Drug: Placebo
Sponsors:   Massachusetts General Hospital;   The Salah Foundation;   MGH cure ALS Fund
Recruiting


A Study to Evaluate Efficacy, Safety and Tolerability of CK-2127107 in Patients With Amyotrophic Lateral Sclerosis (ALS)


Condition:   Amyotrophic Lateral Sclerosis
Interventions:   Drug: CK-2127107;   Drug: Placebo
Sponsors:   Cytokinetics;   Astellas Pharma Inc
Recruiting


Virtual Task in Amyotrophic Lateral Sclerosis


Condition:   Amyotrophic Lateral Sclerosis
Interventions:   Device: Acquisition on TouchScreen;   Device: Acquisition on Kinect;   Device: Acquisition on LeapMotion;   Device: Acquisition on TouchScreen Control Group;   Device: Acquisition on Kinect Control Group;   Device: Acquisition on LeapMotion Control Group
Sponsor:   University of Sao Paulo
Completed


Trial of Amivita in Amyotrophic Lateral Sclerosis


Condition:   Amyotrophic Lateral Sclerosis
Intervention:   Drug: Amivita
Sponsors:   Wujin People's Hospital;   Nanjing 1718 Biotech Co. Ltd
Recruiting


Transplantation of Autologous Peripheral Blood Mononuclear Cells for Amyotrophic Lateral Sclerosis


Condition:   Amyotrophic Lateral Sclerosis
Intervention:   Biological: PBMC autotransplantation
Sponsor:   The First Affiliated Hospital of Dalian Medical University
Completed


Amyotrophic Lateral Sclerosis: a New Paradigm


Condition:   Amyotrophic Lateral Sclerosis
Intervention:   Other: study ALS patients
Sponsor:   Conde, Bebiana, M.D.
Recruiting


Nebulized RNS60 for the Treatment of Amyotrophic Lateral Sclerosis


Condition:   Amyotrophic Lateral Sclerosis
Interventions:   Drug: RNS60;   Drug: Placebo
Sponsor:   Revalesio Corporation
Not yet recruiting


Study of Gene Polymorphisms Involved in the Metabolism and Action of Vitamin D in Amyotrophic Lateral Sclerosis


Condition:   Amyotrophic Lateral Sclerosis
Intervention:  
Sponsor:   Centre Hospitalier Universitaire de Nīmes
Completed


Accurate Screening Tools for Dysphagia in Amyotrophic Lateral Sclerosis (ALS)


Condition:   Amyotrophic Lateral Sclerosis
Interventions:   Device: Micro Mouth Pressure Meter;   Device: Iowa Oral Performance Instrument;   Device: Electrical Impedance Myography;   Drug: Capsaicin;   Procedure: Videofluoroscopic Swallowing Study;   Procedure: Pulmonary Function Testing;   Other: Swallowing Related Quality of Life Questionnaire;   Other: Functional Oral Intake Scale;   Other: Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised;   Other: Eating Assessment Tool-10;   Other: Communicative Effectiveness Survey;   Other: The Center for Neurologic Studies Bulbar Function Scale
Sponsor:   University of Florida
Completed


Respiratory Strength Training in Persons With Amyotrophic Lateral Sclerosis (ALS)


Condition:   Amyotrophic Lateral Sclerosis
Interventions:   Device: PowerLung trainer;   Device: Micro Mouth Pressure Meter;   Procedure: Pulmonary Function Testing;   Procedure: Videofluoroscopic swallowing study;   Other: Swallowing Quality of Life Questionnaire;   Device: Iowa Oral Pressure Instrument;   Drug: Capsaicin
Sponsors:   University of Florida;   ALS Association
Recruiting


Muscular Biomarkers in Amyotrophic Lateral Sclerosis


Condition:   Amyotrophic Lateral Sclerosis
Intervention:   Other: Samples
Sponsor:   University Hospital, Tours
Recruiting


Exploratory Study of Biotelemetry in Amyotrophic Lateral Sclerosis


Condition:   Amyotrophic Lateral Sclerosis
Interventions:   Device: Faros Sensor (FS) and LifeInsight Hub;   Device: Fast Fix electrode patch;   Procedure: Quantitative Measure of Speech (Core Phase Only)
Sponsor:   GlaxoSmithKline
Completed


HERV-K Suppression Using Antiretroviral Therapy in Volunteers With Amyotrophic Lateral Sclerosis (ALS)


Condition:   Amyotrophic Lateral Sclerosis
Interventions:   Drug: Darunavir;   Drug: Ritonavir;   Drug: Raltegravir;   Drug: Zidovudine
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Enrolling by invitation


Therapeutic Imaging Biomarkers for Amyotrophic Lateral Sclerosis


Condition:   Amyotrophic Lateral Sclerosis
Intervention:   Other: MRI
Sponsor:   University of Michigan
Active, not recruiting


Safety Study of VM202 to Treat Amyotrophic Lateral Sclerosis


Condition:   Amyotrophic Lateral Sclerosis
Intervention:   Genetic: VM202
Sponsor:   ViroMed Co., Ltd.
Completed


The National Amyotrophic Lateral Sclerosis Registry


Condition:   Amyotrophic Lateral Sclerosis
Intervention:  
Sponsors:   Centers for Disease Control and Prevention;   VA Office of Research and Development;   Centers for Medicare and Medicaid Services
Recruiting


Study of Ozanezumab (GSK1223249) Versus Placebo in the Treatment of Amyotrophic Lateral Sclerosis


Condition:   Amyotrophic Lateral Sclerosis
Interventions:   Drug: Ozanezumab;   Drug: Placebo
Sponsor:   GlaxoSmithKline
Completed

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