Weight Loss

About Weight Loss Clinical Trials (Click to Open)

Join Clinical Trials for Weight Loss

Clinical Trials for Weight LossGeneral Purpose:

 Being overweight puts you at risk of developing many cardiovascular diseases and can negatively impact your quality of life. Weight loss and dieting have become a billion dollar industry due to the excessive need in this country. Being overweight can impede all aspects of your life, and while many are able to find weight loss programs that work for them, just as many are not.

As a result, clinical trials for weight loss are working relentlessly to find improved interventional methods. These include surgical, pharmaceutical, and behavioral approaches. Observational studies often include identification and characterization in order to gain a better understanding of how weight loss and dieting can be made most effective based upon specific demographics.

Current clinical research is exhibiting the impact of physiology and genetics as contributing factors in becoming overweight. If you are struggling with your weight, participating in a clinical trial is an excellent way to take that first step towards shedding excessive weight and making a positive impact on your health.

All clinical trials for weight loss will attempt to provide you personal benefit that improves your quality of life, while also using information provided by your trial experience to help find improved weight loss strategies for the general public.

What will Weight Loss Clinical Trials be like?

Your eligibility must first be evaluated during a screening phase to ensure that you are the right fit for the trial. The goal of these trials is to improve the quality of life of those struggling with weight loss, so the researchers want to ensure that there is a potential benefit for you to gain from your participation in the trial.

You must also be motivated to lose weight and comply with protocol requirements Clinical Trials for Weight Lossattempting to accomplish that positive result. These criteria are also there to prevent you from experiencing any detrimental pharmaceutical interactions with another medication that you are taking.

The researchers will therefore ask you to provide a very detailed medical history. They will also likely give you a clinical assessment of your current (baseline) health status and determine your BMI, which should likely exceed 25.

They may also require individuals who are active, healthy, and not smokers. If women are of childbearing age, some trials may require that they use an appropriate form of contraception. Surgical intervention trials will ensure that participants are eligible to undergo such interventional methods.

Typical Weight Loss/Dieting Clinical Trial Protocol:

If the main interventional method being tested is a pharmaceutical or supplement, you will be randomly assigned to a group that either receives a varying dose of the treatment/supplement or a control.

If a surgical procedure is part of the treatment, participants will be randomly assigned to a group receiving an interventional surgery, such as gastric bypass, to evaluate the beneficial impact on weight loss.

These trials will also often attempt to determine who benefits the most from such weight loss surgeries and will follow participants throughout the weight loss period. Detailed medical evaluations will be conducted to assess biological changes associated with weight loss.

Monitoring during interventional trials may include weight and leptin levels, both at specified time points and after certain weight loss bench marks have been accomplished, as well as when weight has been stabilized.

A behavioral intervention trial may conduct a comparative analysis between two different forms of exercise or diet programs to determine which best facilitate weight loss and improve health.

They would determine this by having specified checkpoints throughout the duration of the study, in which they obtain assessments of the treatment’s success. This may include weight, BMI, body composition, blood changes, etc. Other studies might take an observational approach and characterize the population based on varying factors.

In genetic observational trials, potential participants will be given a genetic assessment to determine if there is any specific mutation present, or to retrospectively assess if there are common traits present within a large population of overweight individuals enrolled in the trial.

Suggested Search Terms:

Surgical Interventions for Weight Loss, Programs to Promote Weight Loss and Dieting, Safety and Effectiveness of Weight Loss Supplements, Exercise and Weight loss, Caloric Restriction and Weight Loss

Current Search Term:

“Weight Loss”

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Smart Technology for Weight Loss and Metabolic Health

Conditions:   Obesity;   Overweight;   Prediabetes;   Weight Loss;   Lifestyle
Interventions:   Device: Wearable technology, smartscale;   Behavioral: Smartphone applications;   Behavioral: Standard Weight Management Visits
Sponsors:   Temple University;   The Obesity Treatment Foundation
Not yet recruiting - verified April 2016

Effect of High Protein Weight Loss for Seniors

Conditions:   Obesity;   Weight Loss
Intervention:   Behavioral: Weight Stable Group
Sponsors:   Wake Forest University;   Wake Forest School of Medicine
Recruiting - verified April 2016

Weight Loss Prior Mamma Reduction - A Pilot Study

Conditions:   Weight Loss;   Hypertrophy
Intervention:   Dietary Supplement: Low energy diet
Sponsor:   Copenhagen University Hospital at Herlev
Active, not recruiting - verified January 2016

Mastopexy With Autologous Augmentation in Women After Massive Weight Loss - A Clinical, Randomized Study

Condition:   Weight Loss
Interventions:   Procedure: Rubins Mastopexy;   Procedure: LOPOSAM
Sponsor:   Odense University Hospital
Recruiting - verified October 2015

Litramine for Weight Loss

Condition:   Weight Loss
Intervention:   Dietary Supplement: Litramine
Sponsor:   InQpharm Group
Completed - verified August 2015

Effect of Moderate Weight Loss in Metabolically Abnormal Lean Subjects

Condition:   Weight Loss
Intervention:   Other: Moderate (8-10%) diet-induced weight loss
Sponsor:   Washington University School of Medicine
Recruiting - verified April 2016

Effect of Soy Protein and Colorado Diet on Weight Loss and Maintenance

Conditions:   Overweight;   Obesity;   Weight Loss
Interventions:   Dietary Supplement: Colorado Diet with soy protein foods.;   Behavioral: Colorado Diet with monetary payments
Sponsors:   DuPont Nutrition and Health;   University of Colorado, Denver
Active, not recruiting - verified September 2015

Effect of Two Diets With Different Content of Protein on Weight Loss in Adults With Metabolic Syndrome

Conditions:   Metabolic Syndrome X;   Weight Loss
Interventions:   Other: High protein diet;   Other: Low protein diet
Sponsor:   Mexican National Institute of Public Health
Completed - verified March 2016

Comparison of Different Weight Loss Diets With Different Protein Content

Conditions:   Weight Loss;   Insulin Resistance
Interventions:   Dietary Supplement: BCAA;   Dietary Supplement: Placebo (For BCAA)
Sponsor:   Lee Yung Seng
Recruiting - verified October 2015

Project Impact: An Innovative Approach to Weight Loss Maintenance

Conditions:   Obesity;   Weight Loss;   Overweight
Interventions:   Behavioral: Gold Standard Behavior Therapy for Weight Loss;   Behavioral: Behavior Therapy for Weight Loss with Physical Activity Emphasis;   Behavioral: Acceptance-based Behavior Therapy for Weight Loss with PA emphasis
Sponsor:   Drexel University
Active, not recruiting - verified April 2016

Timing of Meals for Weight Loss

Conditions:   Overweight;   Obesity;   Weight Loss
Interventions:   Behavioral: Eat majority of calories in the morning;   Behavioral: Eat the majority of calories in the evening
Sponsor:   University of Tennessee
Active, not recruiting - verified January 2016

A High Protein Weight Loss Intervention for Sarcopenic Obesity in Women

Conditions:   Weight Loss;   Obesity
Interventions:   Dietary Supplement: Protein supplementation;   Behavioral: Diet counseling and group education lessons
Sponsors:   Duke University;   National Pork Board
Active, not recruiting - verified May 2016

Postpartum Weight Loss and Sleep Amongst Obese Women

Conditions:   Obesity;   Sleep Disordered Breathing;   Weight Loss;   Postpartum;   Insomnia
Intervention:   Behavioral: Go!®to sleep
Sponsor:   University of South Florida
Completed - verified May 2016

Bitter Taste and Weight Loss in Women

Conditions:   Obesity;   Weight Loss
Interventions:   Behavioral: Low-Carbohydrate Diet;   Behavioral: Low-fat Diet
Sponsor:   Rutgers University
Active, not recruiting - verified December 2015

Ultrasound Characterization of Ovarian Morphology During Weight Loss in Women With Polycystic Ovary Syndrome (PCOS)

Conditions:   Weight Loss;   Anovulation;   Amenorrhea;   Infertility
Intervention:   Behavioral: Commercial diet
Sponsors:   Cornell University;   Nutrisystem, Inc.
Completed - verified June 2015

Weight Loss Study-Mechanism Underlying the Improvement of Insulin Resistance in Response to Weight Loss

Conditions:   Obesity;   Weight Loss
Intervention:   Dietary Supplement: Weight loss group (Full meal replacement products)
Sponsor:   Beth Israel Deaconess Medical Center
Active, not recruiting - verified December 2015

Effect of Exercise-Induced Weight Loss on Energy Metabolism

Conditions:   Metabolism;   Weight Loss
Sponsor:   Pennington Biomedical Research Center
Completed - verified May 2016

Weight Loss and Maintenance for Individuals With Intellectual Developmental Disabilities (IDD)

Condition:   Weight Loss
Interventions:   Dietary Supplement: Modified Stop Light Diet (SLDm);   Dietary Supplement: Recommended Care Diet
Sponsor:   Joseph Donnelly
Completed - verified December 2015

PILI at Work a 5-Year Controlled Intervention Trial: Testing DVD Versus Group Delivery of a Weight-Loss Maintenance Intervention in Native Hawaiian- Serving Worksites

Conditions:   Obesity;   Overweight;   Weight Loss;   Weight Loss Maintenance
Interventions:   Behavioral: Weight loss maintenance intervention face-to-face;   Behavioral: Weight loss maintenance intervention delivered via DVD
Sponsors:   University of Hawaii;   Queen's Medical Centre;   I Ola Lahui, Inc.;   Queen Lili'uokalani Children's Center;   Ke Ola Mamo;   Molokai Community Health Center;   Keiki o ka Aina
Completed - verified July 2012

Weight Tracking and Weight Loss Outcomes: Establishing the Standard of Care

Condition:   Weight Loss
Intervention:   Behavioral: 12 month behavioral weight loss intervention
Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Completed - verified November 2015

An Open-Label Pilot Trial of Alpha Lipoic Acid (ALA) for Weight Loss in Schizophrenia

Conditions:   Obesity;   Weight Loss;   Schizophrenia
Intervention:   Dietary Supplement: Alpha Lipoic Acid
Sponsor:   Yale University
Completed - verified November 2015

University Of Pennsylvania Weight Loss Study

Condition:   Weight Loss
Interventions:   Behavioral: Deposit contract with a 1:1 match;   Behavioral: Deposit contract with a 2:1 match;   Behavioral: Deposit Contract with no match
Sponsors:   University of Pennsylvania;   Carnegie Mellon University;   Harvard University;   incentaHEALTH;   McKinsey & Company
Active, not recruiting - verified September 2012

Alternate Day Fasting for Weight Loss, Weight Maintenance and Cardio-protection

Conditions:   Coronary Heart Disease;   Obesity;   Weight Loss
Interventions:   Other: Alternate day fasting;   Other: Calorie restriction;   Other: Control diet
Sponsors:   University of Illinois at Chicago;   Pennington Biomedical Research Center;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified January 2016

The Effects of Exenatide (Byetta ) on Energy Expenditure and Weight Loss in Nondiabetic Obese Subjects

Conditions:   Weight Loss;   Obesity
Interventions:   Drug: Byetta (exenatide);   Behavioral: Weight loss;   Other: Metabolic Chamber;   Drug: Placebo
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified November 2015

Effects of Brain Stimulation on Food Intake and Behavioral Weight Loss Treatment

Conditions:   Electric Stimulation Therapy;   Obesity;   Weight Loss;   Eating
Interventions:   Behavioral: Behavioral Weight Loss Treatment;   Procedure: Transcranial Direct Current Stimulation (TDCS);   Device: Transcranial Direct Current Stimulation (TDCS);   Behavioral: Appetite Control;   Procedure: Appetite Control;   Device: Weight Control;   Behavioral: Weight Loss
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified May 2016

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