Weight Loss

About Weight Loss Clinical Trials (Click to Open)

Join Clinical Trials for Weight Loss

Clinical Trials for Weight LossGeneral Purpose:

 Being overweight puts you at risk of developing many cardiovascular diseases and can negatively impact your quality of life. Weight loss and dieting have become a billion dollar industry due to the excessive need in this country. Being overweight can impede all aspects of your life, and while many are able to find weight loss programs that work for them, just as many are not.

As a result, clinical trials for weight loss are working relentlessly to find improved interventional methods. These include surgical, pharmaceutical, and behavioral approaches. Observational studies often include identification and characterization in order to gain a better understanding of how weight loss and dieting can be made most effective based upon specific demographics.

Current clinical research is exhibiting the impact of physiology and genetics as contributing factors in becoming overweight. If you are struggling with your weight, participating in a clinical trial is an excellent way to take that first step towards shedding excessive weight and making a positive impact on your health.

All clinical trials for weight loss will attempt to provide you personal benefit that improves your quality of life, while also using information provided by your trial experience to help find improved weight loss strategies for the general public.

What will Weight Loss Clinical Trials be like?

Your eligibility must first be evaluated during a screening phase to ensure that you are the right fit for the trial. The goal of these trials is to improve the quality of life of those struggling with weight loss, so the researchers want to ensure that there is a potential benefit for you to gain from your participation in the trial.

You must also be motivated to lose weight and comply with protocol requirements Clinical Trials for Weight Lossattempting to accomplish that positive result. These criteria are also there to prevent you from experiencing any detrimental pharmaceutical interactions with another medication that you are taking.

The researchers will therefore ask you to provide a very detailed medical history. They will also likely give you a clinical assessment of your current (baseline) health status and determine your BMI, which should likely exceed 25.

They may also require individuals who are active, healthy, and not smokers. If women are of childbearing age, some trials may require that they use an appropriate form of contraception. Surgical intervention trials will ensure that participants are eligible to undergo such interventional methods.

Typical Weight Loss/Dieting Clinical Trial Protocol:

If the main interventional method being tested is a pharmaceutical or supplement, you will be randomly assigned to a group that either receives a varying dose of the treatment/supplement or a control.

If a surgical procedure is part of the treatment, participants will be randomly assigned to a group receiving an interventional surgery, such as gastric bypass, to evaluate the beneficial impact on weight loss.

These trials will also often attempt to determine who benefits the most from such weight loss surgeries and will follow participants throughout the weight loss period. Detailed medical evaluations will be conducted to assess biological changes associated with weight loss.

Monitoring during interventional trials may include weight and leptin levels, both at specified time points and after certain weight loss bench marks have been accomplished, as well as when weight has been stabilized.

A behavioral intervention trial may conduct a comparative analysis between two different forms of exercise or diet programs to determine which best facilitate weight loss and improve health.

They would determine this by having specified checkpoints throughout the duration of the study, in which they obtain assessments of the treatment’s success. This may include weight, BMI, body composition, blood changes, etc. Other studies might take an observational approach and characterize the population based on varying factors.

In genetic observational trials, potential participants will be given a genetic assessment to determine if there is any specific mutation present, or to retrospectively assess if there are common traits present within a large population of overweight individuals enrolled in the trial.

Suggested Search Terms:

Surgical Interventions for Weight Loss, Programs to Promote Weight Loss and Dieting, Safety and Effectiveness of Weight Loss Supplements, Exercise and Weight loss, Caloric Restriction and Weight Loss

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“Weight Loss”

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Effect of Soy Protein and Colorado Diet on Weight Loss and Maintenance


Conditions:   Overweight;   Obesity;   Weight Loss
Interventions:   Dietary Supplement: Colorado Diet with soy protein foods.;   Behavioral: Colorado Diet with monetary payments
Sponsors:   DuPont Nutrition and Health;   University of Colorado, Denver
Recruiting - verified March 2015


Weight Loss and Prevention in Latina Immigrants: Advancing Methods of Community-Based Intervention Delivery


Condition:   Weight Loss
Intervention:   Behavioral: ESENCIAL Para Vivir: a weight loss program for Latinas
Sponsors:   University of Alabama at Birmingham;   UAB Diabetes Research  Center;   UAB Nutrition Obesity Research Center;   UAB Minority Health & Research Center;   Robert Wood Johnson Foundation
Completed - verified January 2015


mHealth Messages to Sustain Recent Weight Loss - Phase 2


Condition:   Weight Loss
Intervention:   Behavioral: mHealth Texting for Weight Loss
Sponsor:   Duke University
Recruiting - verified February 2015


Effect of Two Diets With Different Content of Protein on Weight Loss in Adults With Metabolic Syndrome


Conditions:   Metabolic Syndrome X;   Weight Loss
Intervention:   Other: High protein diet
Sponsor:   Mexican National Institute of Public Health
Enrolling by invitation - verified February 2015


Comparison of Different Weight Loss Diets With Different Protein Content


Conditions:   Weight Loss;   Insulin Resistance
Interventions:   Dietary Supplement: BCAA;   Dietary Supplement: Placebo (For BCAA)
Sponsor:   Lee Yung Seng
Recruiting - verified October 2014


Timing of Meals for Weight Loss


Conditions:   Overweight;   Obesity;   Weight Loss
Interventions:   Behavioral: Eat majority of calories in the morning;   Behavioral: Eat the majority of calories in the evening
Sponsor:   University of Tennessee
Active, not recruiting - verified March 2015


Body Contouring Surgery After Massive Weight Loss


Condition:   Weight Loss
Intervention:   Procedure: Body Contouring Surgery
Sponsor:   University Hospital, Basel, Switzerland
Completed - verified March 2015


Study of Weight Loss Effect of the Sequential Balloons


Conditions:   Weight Loss;   Balloons
Intervention:   Device: Heliosphere bag (air filled balloon)
Sponsor:   Mansoura University
Recruiting - verified May 2014


Endoscopic Gastric Plication for Weight Loss in Morbidly Obese Patients Prior to Incisional Hernia Repair


Conditions:   Morbid Obesity;   Weight Loss;   Complex Incisional Hernias
Intervention:   Procedure: Endoscopic Gastric Plication
Sponsor:   University of California, San Francisco
Not yet recruiting - verified September 2014


A High Protein Weight Loss Intervention for Sarcopenic Obesity in Women


Conditions:   Weight Loss;   Obesity
Interventions:   Dietary Supplement: Protein supplementation;   Behavioral: Diet counseling and group education lessons
Sponsors:   Duke University;   National Pork Board
Recruiting - verified January 2015


Postpartum Weight Loss and Sleep Amongst Obese Women


Conditions:   Obesity;   Sleep Disordered Breathing;   Weight Loss;   Postpartum;   Insomnia
Intervention:   Behavioral: Go!®to sleep
Sponsor:   University of South Florida
Recruiting - verified January 2015


Bitter Taste and Weight Loss in Women


Conditions:   Obesity;   Weight Loss
Interventions:   Behavioral: Low-Carbohydrate Diet;   Behavioral: Low-fat Diet
Sponsor:   Rutgers University
Active, not recruiting - verified March 2015


Endoscopic Surgery for Bariatric Revision After Weight Loss Failure


Conditions:   Morbid Obesity;   Weight Loss
Intervention:   Device: Endoscopic Suturing to Create Early Satiety
Sponsor:   University of California, San Francisco
Recruiting - verified September 2014


Ultrasound Characterization of Ovarian Morphology During Weight Loss in Women With Polycystic Ovary Syndrome (PCOS)


Conditions:   Weight Loss;   Anovulation;   Amenorrhea;   Infertility
Intervention:   Behavioral: Commercial diet
Sponsors:   Cornell University;   Nutrisystem, Inc.
Recruiting - verified November 2014


Weight Loss Study-Mechanism Underlying the Improvement of Insulin Resistance in Response to Weight Loss


Conditions:   Obesity;   Weight Loss
Intervention:   Dietary Supplement: Weight loss group (Full meal replacement products)
Sponsor:   Beth Israel Deaconess Medical Center
Active, not recruiting - verified October 2014


Effect of Exercise-Induced Weight Loss on Energy Metabolism


Conditions:   Metabolism;   Weight Loss
Intervention:  
Sponsor:   Pennington Biomedical Research Center
Recruiting - verified August 2014


Weight Loss and Maintenance for Individuals With Intellectual Developmental Disabilities (IDD)


Condition:   Weight Loss
Interventions:   Dietary Supplement: Modified Stop Light Diet (SLDm);   Dietary Supplement: Recommended Care Diet
Sponsor:   Joseph Donnelly
Active, not recruiting - verified December 2014


Weight Tracking and Weight Loss Outcomes: Establishing the Standard of Care


Condition:   Weight Loss
Intervention:   Behavioral: 12 month behavioral weight loss intervention
Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Active, not recruiting - verified July 2014


Use of Probiotics to Aid in Weight Loss


Condition:   Weight Loss
Interventions:   Dietary Supplement: Probiotics;   Dietary Supplement: Placebo
Sponsors:   Greenville Hospital System University Medical Center;   Xymogen, Inc.
Completed - verified April 2014


Testing Strategies to Encourage Weight Loss in an Employer Setting


Condition:   Weight Loss
Interventions:   Behavioral: No intervention;   Behavioral: Group-based payout;   Behavioral: Individual payout
Sponsors:   University of Pennsylvania;   Children's Hospital of Philadelphia;   IncentaHEALTH;   National Institutes of Health (NIH);   National Institute on Aging (NIA)
Completed - verified September 2012


mDiet: A Text Message Intervention for Weight Loss


Conditions:   Overweight;   Weight Loss
Intervention:   Behavioral: mDiet
Sponsor:   University of California, San Diego
Completed - verified December 2014


Impact of Group Size in Weight Loss Interventions


Conditions:   Obesity;   Weight Loss
Intervention:   Behavioral: behavioral weight loss program
Sponsor:   Florida State University
Completed - verified March 2015


The Effects of Exenatide (Byetta ) on Energy Expenditure and Weight Loss in Nondiabetic Obese Subjects


Conditions:   Weight Loss;   Obesity
Interventions:   Drug: Byetta (exenatide);   Behavioral: Weight loss;   Other: Metabolic Chamber;   Drug: Placebo
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified December 2014


Effects of Brain Stimulation on Food Intake and Behavioral Weight Loss Treatment


Conditions:   Electric Stimulation Therapy;   Obesity;   Weight Loss;   Eating
Interventions:   Behavioral: Behavioral Weight Loss Treatment;   Procedure: Transcranial Direct Current Stimulation (TDCS);   Device: Transcranial Direct Current Stimulation (TDCS);   Behavioral: Appetite Control;   Procedure: Appetite Control;   Device: Weight Control;   Behavioral: Weight Loss
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified June 2014


Olanzapine in Patients With Advanced Cancer and Weight Loss


Conditions:   Advanced Cancer;   Weight Loss
Intervention:   Drug: Olanzapine
Sponsor:   M.D. Anderson Cancer Center
Completed - verified January 2015

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