Weight Loss

About Weight Loss Clinical Trials (Click to Open)

Join Clinical Trials for Weight Loss

Clinical Trials for Weight LossGeneral Purpose:

 Being overweight puts you at risk of developing many cardiovascular diseases and can negatively impact your quality of life. Weight loss and dieting have become a billion dollar industry due to the excessive need in this country. Being overweight can impede all aspects of your life, and while many are able to find weight loss programs that work for them, just as many are not.

As a result, clinical trials for weight loss are working relentlessly to find improved interventional methods. These include surgical, pharmaceutical, and behavioral approaches. Observational studies often include identification and characterization in order to gain a better understanding of how weight loss and dieting can be made most effective based upon specific demographics.

Current clinical research is exhibiting the impact of physiology and genetics as contributing factors in becoming overweight. If you are struggling with your weight, participating in a clinical trial is an excellent way to take that first step towards shedding excessive weight and making a positive impact on your health.

All clinical trials for weight loss will attempt to provide you personal benefit that improves your quality of life, while also using information provided by your trial experience to help find improved weight loss strategies for the general public.

What will Weight Loss Clinical Trials be like?

Your eligibility must first be evaluated during a screening phase to ensure that you are the right fit for the trial. The goal of these trials is to improve the quality of life of those struggling with weight loss, so the researchers want to ensure that there is a potential benefit for you to gain from your participation in the trial.

You must also be motivated to lose weight and comply with protocol requirements Clinical Trials for Weight Lossattempting to accomplish that positive result. These criteria are also there to prevent you from experiencing any detrimental pharmaceutical interactions with another medication that you are taking.

The researchers will therefore ask you to provide a very detailed medical history. They will also likely give you a clinical assessment of your current (baseline) health status and determine your BMI, which should likely exceed 25.

They may also require individuals who are active, healthy, and not smokers. If women are of childbearing age, some trials may require that they use an appropriate form of contraception. Surgical intervention trials will ensure that participants are eligible to undergo such interventional methods.

Typical Weight Loss/Dieting Clinical Trial Protocol:

If the main interventional method being tested is a pharmaceutical or supplement, you will be randomly assigned to a group that either receives a varying dose of the treatment/supplement or a control.

If a surgical procedure is part of the treatment, participants will be randomly assigned to a group receiving an interventional surgery, such as gastric bypass, to evaluate the beneficial impact on weight loss.

These trials will also often attempt to determine who benefits the most from such weight loss surgeries and will follow participants throughout the weight loss period. Detailed medical evaluations will be conducted to assess biological changes associated with weight loss.

Monitoring during interventional trials may include weight and leptin levels, both at specified time points and after certain weight loss bench marks have been accomplished, as well as when weight has been stabilized.

A behavioral intervention trial may conduct a comparative analysis between two different forms of exercise or diet programs to determine which best facilitate weight loss and improve health.

They would determine this by having specified checkpoints throughout the duration of the study, in which they obtain assessments of the treatment’s success. This may include weight, BMI, body composition, blood changes, etc. Other studies might take an observational approach and characterize the population based on varying factors.

In genetic observational trials, potential participants will be given a genetic assessment to determine if there is any specific mutation present, or to retrospectively assess if there are common traits present within a large population of overweight individuals enrolled in the trial.

Suggested Search Terms:

Surgical Interventions for Weight Loss, Programs to Promote Weight Loss and Dieting, Safety and Effectiveness of Weight Loss Supplements, Exercise and Weight loss, Caloric Restriction and Weight Loss

Current Search Term:

“Weight Loss”

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Does Dapagliflozin Provide Additional Health Benefits To Dietary Counseling For Weight Loss?


Condition:   Weight Loss
Interventions:   Drug: Dapagliflozin Tablet;   Drug: Placebo Tablet
Sponsors:   Christopher Bell;   AstraZeneca
Recruiting - verified June 2017


The Effect of Mild Weight Loss on Circulating Metabolite Profiles


Conditions:   Visceral Fat;   Weight Loss
Interventions:   Behavioral: Control group;   Behavioral: LCD group
Sponsor:   Yonsei University
Completed - verified April 2017


Mighty Men: A Faith-Based Weight Loss Program to Address Cancer Disparities


Condition:   Weight Loss
Intervention:   Behavioral: Mighty Men Intervention
Sponsors:   Vanderbilt University;   American Cancer Society, Inc.
Not yet recruiting - verified April 2017


The Effects of a Commercially Available Weight Loss Program on Body Weight in Overweight Men and Women


Conditions:   Overweight and Obesity;   Weight Loss
Interventions:   Behavioral: Nutrisystem;   Behavioral: Self-Directed DASH
Sponsors:   Nutrisystem, Inc.;   The Center for Applied Health Sciences;   Omega Statistics
Completed - verified February 2017


Evaluation of a Commercial Program on Weight Loss and Health Outcomes 2


Condition:   Weight Loss
Intervention:   Behavioral: Intervention
Sponsor:   University of Pittsburgh
Recruiting - verified March 2017


Study to Evaluate Effects of a Weight Loss Program in Different Formats on Healthy Adults


Conditions:   Overweight and Obesity;   Weight Loss
Interventions:   Behavioral: Nutrisystem Turbo 10;   Behavioral: Nutrisystem My Way;   Behavioral: Nutrisystem DASH;   Behavioral: Dieting on Your Own (DIY) - DASH
Sponsors:   Nutrisystem, Inc.;   Biofortis Clinical Research, Inc.
Completed - verified January 2017


Gestational Weight Gain and Postpartum Weight Loss in Active Duty Women (Moms Fit 2 Fight)


Conditions:   Weight Gain;   Weight Loss
Interventions:   Behavioral: Gestational weight gain intervention;   Behavioral: Postpartum weight loss intervention
Sponsors:   University of Tennessee;   Wilford Hall Ambulatory Surgical Center;   San Antonio Military Medical Center;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   University of Tennessee Health Science Center
Recruiting - verified November 2016


Running Versus Interrupted Deep Plane Sutures in Massive Weight Loss Patients


Condition:   Weight Loss
Interventions:   Other: Running sutures;   Other: Interrupted sutures
Sponsors:   St Joseph University, Beirut, Lebanon;   Groupe Hospitalier Paris Saint Joseph
Recruiting - verified December 2016


SMART Weight Loss Management


Condition:   Weight Loss
Interventions:   Behavioral: Step 1 Treatment: APP;   Behavioral: Step 1 Treatment: APP + Coaching;   Behavioral: Step 2 Treatment Strategy: Modest Step-up;   Behavioral: Step 2 Treatment Strategy: Vigorous Step-up
Sponsors:   Northwestern University;   University of Michigan;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified June 2017


Effects of a Weight Loss Intervention in College-age Women


Condition:   Weight Loss
Interventions:   Behavioral: Counseling;   Behavioral: No Counseling
Sponsor:   Texas Christian University
Not yet recruiting - verified November 2016


Helping Employees Lose Pounds


Condition:   Weight Loss
Intervention:   Behavioral: Weekly Incentive
Sponsor:   University of Michigan
Completed - verified April 2017


Using an API to Commercialize an Evidence-Based Weight Loss Intervention


Conditions:   Weight Loss;   Health Behavior
Interventions:   Behavioral: API App;   Behavioral: Non-API App;   Behavioral: fitness tracker;   Behavioral: scale
Sponsor:   Coeus Health, LLC
Not yet recruiting - verified February 2017


Effect of High Protein Weight Loss for Seniors


Conditions:   Obesity;   Weight Loss
Intervention:   Behavioral: Weight Stable Group
Sponsors:   Wake Forest University;   Wake Forest University Health Sciences
Completed - verified April 2017


Weight Loss Prior Mamma Reduction - A Pilot Study


Conditions:   Weight Loss;   Hypertrophy
Intervention:   Dietary Supplement: Low energy diet
Sponsor:   Copenhagen University Hospital at Herlev
Completed - verified August 2016


Does Dapagliflozin Promote Favorable Health Benefits That Are Independent Of Weight Loss?


Condition:   Weight Loss
Interventions:   Drug: Dapagliflozin;   Drug: Placebo;   Behavioral: Weight maintenance;   Behavioral: Ad libitum dietary intake;   Behavioral: Dietary restriction
Sponsors:   Christopher Bell;   AstraZeneca
Recruiting - verified January 2017


Effect of Moderate Weight Loss in Metabolically Abnormal Lean Subjects


Condition:   Weight Loss
Intervention:   Other: Moderate (8-10%) diet-induced weight loss
Sponsor:   Washington University School of Medicine
Recruiting - verified January 2017


mHealth Messages to Sustain Recent Weight Loss - Phase 2


Condition:   Weight Loss
Intervention:   Behavioral: mHealth Texting for Weight Loss
Sponsor:   Duke University
Completed - verified March 2016


Comparison of Different Weight Loss Diets With Different Protein Content


Conditions:   Weight Loss;   Insulin Resistance
Interventions:   Dietary Supplement: BCAA;   Dietary Supplement: Placebo (For BCAA)
Sponsor:   Lee Yung Seng
Recruiting - verified December 2016


Feasibility Trial of a Problem-Solving Weight Loss Mobile Application


Conditions:   Obesity;   Weight Loss
Intervention:   Behavioral: Diabetes Prevention Program Lifestyle Intervention
Sponsors:   University of Massachusetts, Worcester;   Worcester Polytechnic Institute
Active, not recruiting - verified January 2017


A High Protein Weight Loss Intervention for Sarcopenic Obesity in Women


Conditions:   Weight Loss;   Obesity
Interventions:   Dietary Supplement: Protein supplementation;   Behavioral: Diet counseling and group education lessons
Sponsors:   Duke University;   National Pork Board
Recruiting - verified June 2017


Exercise Duration Models, in Middle-aged Men


Condition:   Weight Loss
Interventions:   Other: Continuous training;   Other: The interval training
Sponsor:   P.L.Shupik National Medical Academy of Post-Graduate Education
Completed - verified February 2017


Effect of Exercise-Induced Weight Loss on Energy Metabolism


Conditions:   Metabolism;   Weight Loss
Intervention:  
Sponsor:   Pennington Biomedical Research Center
Completed - verified April 2017


University Of Pennsylvania Weight Loss Study


Condition:   Weight Loss
Interventions:   Behavioral: Deposit contract with a 1:1 match;   Behavioral: Deposit contract with a 2:1 match;   Behavioral: Deposit Contract with no match
Sponsors:   University of Pennsylvania;   Carnegie Mellon University;   Harvard University;   incentaHEALTH;   McKinsey & Company
Active, not recruiting - verified August 2016


The Effects of Exenatide (Byetta ) on Energy Expenditure and Weight Loss in Nondiabetic Obese Subjects


Conditions:   Weight Loss;   Obesity
Interventions:   Drug: Byetta (exenatide);   Behavioral: Weight loss;   Other: Metabolic Chamber;   Drug: Placebo
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Completed - verified September 19, 2016


Study of Effects From Gastric Bypass Weight Loss on Brain Tissue


Condition:   Weight Loss
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Completed - verified October 3, 2008

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