Vaccines

About Vaccines Clinical Trials (Click to Open)

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Vaccine Clinical TrialsGeneral Purpose:

Vaccine clinical trials will evaluate the immune response and reactogenicity of certain vaccinations within specific populations. Other trials may compare different vaccinations strategies for the same disease. Comparisons may be made between a live attenuated version of a vaccine versus an inactivated version, as well as comparisons between different vaccination schedules.

Clinical trials may assess the effect of age and prior immunity on certain vaccines and across various populations. Some observational studies may attempt to develop a potential predictor of resistance to vaccines within a specific population.

Given the vast and diverse array of vaccines, the purposes will likely vary based upon the specific vaccine that is being studied. These trials intend to advance the scientific body of knowledge surrounding vaccinations in order to promote health and improve quality of life, particularly within an immune-compromised population who are more susceptible to contracting various diseases.

What will Vaccine Clinical Trials be like?

As there are innumerable types of vaccines, inclusion criteria will vary according to the vaccine being evaluated in a trial. The goal is to ensure that you are the proper fit for a trial.

Clinical trials for vaccines will conduct screenings of each potential participant, which may include medical history or clinical diagnosis of a specific virus, such as HIV infection. Alternatively, studies may require only healthy participants, which will be assessed by trial doctors.

Studies may require priming with the vaccine in question, which would involve documentation of previous vaccination. Women of childbearing age may be required to abstain from sex or take contraceptive measures during the clinical trial.

There is an extensive range of prevention and interventional methods being evaluated. As a result, you must make sure to pick a clinical trial that you feel comfortable participating in after reading the informed consent and learning about what it will entail. Inclusion criteria are intended to provide benefit and avoid wasting your time.

Typical Vaccine Clinical Trial Protocol:

Due to the diverse nature of vaccine clinical trials, it is difficult to pinpoint a general outline Vaccine Clinical Trialsregarding trial protocols. However, interventional trials will either randomly or non-randomly assign participants to different treatment groups receiving various vaccines.

If comparison is being made between primed versus immunologically naïve participants, outcome measures may involve cell-mediated immunity and antibody response at certain time points throughout the duration of the trial.

Within a virus infected population with immunosuppression, participants may be given different vaccine strategies or dosages at the beginning of the trial, with certain treatment groups receiving a second dose within a specific time frame thereafter.

At specified times after vaccination, the antibody concentrations will be determined, the rate of formation of antigen-to-antibody binding will be measured, safety of both vaccines will be assessed, and other relevant treatment outcomes will be measured based on that particular trial.

Observational studies will likely administer different vaccines and obtain data at specified time points afterwards in order to perform statistical analyses; this will likely be with the intention of developing statistical models to predict vaccination titer levels based on demographic characteristics and relevant biomarkers.

All vaccine clinical trials intend to help expand the scientific body of knowledge regarding the interplay between vaccination and the immune response. Trials will often work toward the improvement of quality of life within the more susceptible populations, such as immune-compromised and geriatric populations.

Suggested Search Terms:

Vaccination in an Immunosuppressed Population, Geriatric Vaccine Hypo-response, Safety and Efficacy of Pneumococcal Vaccines, Live Attenuated versus Inactivated Influenza Vaccines, H1N1 Vaccine Study

Current Search Term:

“Vaccines”

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