Osteoarthritis

About Osteoarthritis Clinical Trials (Click to Open)

Join Clinical Trials for Osteoarthritis

Clinical Trials for OsteoarthritisGeneral Purpose:

Osteoarthritis results in joint pain and reduced motion, thereby inhibiting activities of daily living. Because osteoarthritis is more than just aging of the joints, clinical research is currently testing improved detection mechanisms, genetic influence, interventional treatments, and educational programs to help people manage their osteoarthritis.

Clinical trials for osteoarthritis may be separated by location of osteoarthritic symptoms, such as hip and knee. Preventative clinical trials will evaluate the combined effects of interventional and educational preventative practices for older adults to improve risk factors for arthritis. Living with osteoarthritis means coping with the pain, so the aim of many clinical trials will be pain management.

Pain management trials will assess the benefits of different medications, exercise, stem cell transplantation, and other interventional measures. Many studies will attempt to improve the basic functioning that is impaired by osteoarthritis, and will use quality of life measures for evaluation.

Some studies may test improved diagnostic measures in order to expedite proper treatment and pain management. These trials are ultimately determined to improve your quality of life. If you are one of many Americans impeded by osteoarthritis, joining a clinical trial is a great way to find a new treatment and help further the body of knowledge about this common condition.

What will Clinical Trials for Osteoarthritis be like?

Before starting a trial, your eligibility will be evaluated through clinical tests and medical Clinical Trials for Osteoarthritishistory to ensure that you are the right fit for the aim of the osteoarthritis trial. The goal is to improve your quality of life, so these inclusion criteria are intended to provide benefit and avoid wasting your time.

Moreover, this criteria is intended to prevent potentially detrimental interactions with another underlying condition or medication that you are taking. You will therefore need to provide the trial coordinators with a detailed medical history.

Clinical assessment of your osteoarthritis must be established, likely through radiographic evidence and a clinician’s diagnosis. If you wish to join a knee OA clinical trial, you will likely be assessed according to the Kellgren and Lawrence scale that ranges from 0 (normal) to 4 (severe). In any OA trial, you will need to provide details about any joint pain or stiffness that you are suffering from.

Typical Osteoarthritis Clinical Trial Protocol:

If the main interventional mechanism being tested is behavioral, such as an exercise program, you will be assigned to an exercise group or given an exercise regimen to follow. You will then be asked to report on your symptoms so that potential benefit can be evaluated.

Functioning will also be assessed at various time points to measure impact. Trials seeking new and improved diagnostic measures will ask you to undergo these new methods, such as magnetic resonance imaging (MRI). Pharmaceutical clinical trials will provide different treatment groups varying doses to assess the treatment’s effectiveness.

You should also note that as with any clinical trial, it is possible that you will be randomly selected for the placebo group. You would therefore undergo the same procedures as the treatment group without receiving the actual treatment being tested.

If a stem cell transplantation procedure is the interventional treatment, participants will be assigned to a group receiving the stem cells, to evaluate the feasibility and safety of this procedure.

Participants will then receive questionnaires to assess the efficacy of the procedure, and will also undergo quantitative MRI to determine if cartilage has been regenerated at specified time periods after the implantation of stem cells.

Suggested Search Terms:

Osteoarthritis Exercise Program, Pain Management in Osteoarthritis, Stem Cells Transplantation for Osteoarthritis, Coping Skills and Osteoarthritis, Osteoarthritis Prevention in Adults

Current Search Term:

“Osteoarthritis”

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The Safety/Efficacy of Human Umbilical Cord Mesenchymal Stem Cells Therapy for Patients With Osteoarthritis


Condition:   Osteoarthritis, Knee
Interventions:   Biological: Low dose mesenchymal stem cells;   Biological: High dose mesenchymal stem cells;   Procedure: Intraarticular injection
Sponsor:   Sclnow Biotechnology Co., Ltd.
Not yet recruiting


The Efficacy and Safety of Invossa K Injection in Patients Diagnosed With Knee Osteoarthritis


Condition:   Osteoarthritis
Interventions:   Biological: Invossa K Inj.;   Drug: Placebo
Sponsor:   Kolon Life Science
Not yet recruiting


Evaluation Effect of Crocina on The Cellular Immune Responses in Osteoarthritis Patients


Condition:   Osteoarthritis, Knee
Interventions:   Drug: Crocin;   Drug: Placebo Oral Tablet
Sponsor:   Mashhad University of Medical Sciences
Active, not recruiting


Electro-acupuncture in Knee Osteoarthritis


Condition:   Knee Osteoarthritis
Intervention:   Device: Electro-acupuncture
Sponsor:   Ping Zhou
Recruiting


The Effects of Two Different Orthosis on Pain, Hand Strength and Function in Patients With Thumb Carpometacarpal Osteoarthritis


Condition:   Osteoarthritis Thumb
Intervention:   Other: orthosis
Sponsor:   Diskapi Teaching and Research Hospital
Not yet recruiting


Efficacy and Safety of Cettum for Knee Osteoarthritis


Condition:   Osteoarthritis, Knee
Interventions:   Device: Cettum;   Procedure: Traditional indirect moxibustion;   Other: Usual care
Sponsors:   Eun Jung Kim;   DongGuk University
Enrolling by invitation


Feasibility of High Intensity Interval Training in Knee Osteoarthritis


Condition:   Knee Osteoarthritis
Intervention:   Behavioral: High intensity interval training (HIIT)
Sponsors:   University of North Carolina, Chapel Hill;   National Institutes of Health (NIH);   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting


Study of the Laboratory-based Evaluation of the Degrees of Activity of Osteoarthritis


Condition:   Osteoarthritis
Intervention:  
Sponsors:   The Republican Research and Practical Center for Epidemiology and Microbiology;   Belarusian Medical Academy of Post-Graduate Education
Enrolling by invitation


Self-administered Acupressure for Knee Osteoarthritis: A Pilot Randomized Controlled Trial


Condition:   Knee Osteoarthritis
Interventions:   Other: Self-acupressure;   Other: Knee health education
Sponsor:   The Hong Kong Polytechnic University
Recruiting


Randomized Double-blind Study on the Treatment of Osteoarthritis of the Bilateral Knee: Autologous Bone Marrow Concentrate vs. Hyaluronic Acid


Condition:   Osteoarthritis, Knee
Interventions:   Biological: injection of autologous bone marrow concentrate;   Biological: injection of hyaluronic acid.
Sponsor:   Istituto Ortopedico Rizzoli
Recruiting


Sinew Acupuncture for Knee Osteoarthritis


Condition:   Knee Osteoarthritis
Interventions:   Other: Sinew acupuncture;   Other: Sham acupuncture
Sponsor:   The University of Hong Kong
Recruiting


The Effectiveness of Kinesio Taping Method for Knee Osteoarthritis.


Condition:   Knee Osteoarthritis
Intervention:   Other: Taping application
Sponsors:   Lithuanian University of Health Sciences;   International Kinesio Taping association
Recruiting


The Study to Evaluate Efficacy and Safety of Celecoxib Capsule in Hand Osteoarthritis Patients


Condition:   Osteoarthritis Hand
Interventions:   Drug: Celecoxib 100 MG;   Drug: Celecoxib 200mg
Sponsor:   Chong Kun Dang Pharmaceutical
Recruiting


A Study to Evaluate the Analgesic Efficacy and Safety of V120083 in Subjects With Osteoarthritis (OA) of the Knee


Condition:   Osteo Arthritis Knee
Interventions:   Drug: V120083;   Drug: Naproxen;   Drug: Placebo
Sponsors:   Purdue Pharma LP;   Shionogi
Completed


Clinical Trial of YYD302 for Treatment of Osteoarthritis of the Knee


Condition:   Osteoarthritis, Knee
Interventions:   Drug: YYD302 2ml;   Drug: YYD302 3ml;   Drug: Placebo 3ml
Sponsor:   Yooyoung Pharmaceutical Co.,Ltd.
Completed


Zushima Plaster for Treating Knee Osteoarthritis


Condition:   Osteoarthritis
Interventions:   Drug: Zushima plaster with high dose;   Drug: Zushima plaster with low dose;   Drug: Indometacin Cataplasms
Sponsors:   Guang'anmen Hospital of China Academy of Chinese Medical Sciences;   Beijing Hospital of Traditional Chinese Medicine;   Beijing Hospital;   Beijing Jishuitan Hospital;   Beijing Shijitan Hospital;   Shanghai Municipal Hospital of Traditional Chinese Medicine;   Gansu Provincial Hospital;   General Hospital of Beijing Military Area
Active, not recruiting


Evaluation of Amniotic Fluid Product in Knee Osteoarthritis


Condition:   Osteoarthritis of the Knee
Interventions:   Other: Amniotic Fluid 4.0ml dose;   Other: Amniotic Fluid 2.0ml dose;   Other: Placebo Control
Sponsor:   MiMedx Group, Inc.
Completed


Does Addition of a Functional Knee Brace Improve Rehabilitation Outcome in Subjects With Osteoarthritis of the Knee?


Condition:   Knee Osteoarthritis
Intervention:   Device: functional knee brace
Sponsor:   Shin Kong Wu Ho-Su Memorial Hospital
Active, not recruiting


STepped Exercise Program for Knee OsteoArthritis


Condition:   Osteoarthritis, Knee
Interventions:   Behavioral: Stepped Exercise Program;   Behavioral: Arthritis Education
Sponsor:   VA Office of Research and Development
Recruiting


Pain Coping Skills Training for African Americans With Osteoarthritis


Condition:   Osteoarthritis
Intervention:   Behavioral: Pain Coping Skills Training (CST)
Sponsors:   University of North Carolina, Chapel Hill;   Patient-Centered Outcomes Research Institute
Active, not recruiting


Physical Therapy Versus Internet-Based Exercise Training for Patients With Knee Osteoarthritis


Condition:   Knee Osteoarthritis
Interventions:   Behavioral: Internet Based Exercise Training;   Behavioral: Physical Therapy
Sponsors:   University of North Carolina, Chapel Hill;   Patient-Centered Outcomes Research Institute
Completed


Pain Expectations in Subjects With Osteoarthritis


Condition:   Osteoarthritis
Interventions:   Drug: Modafinil;   Drug: Gabapentin;   Drug: Placebo
Sponsor:   Wake Forest University Health Sciences
Completed


Treatment of Knee Osteoarthritis by Intra-articular Injection of Bone Marrow Mesenchymal Stem Cells


Condition:   Osteoarthritis
Interventions:   Drug: Hyaluronic acid;   Biological: 10 million Bone marrow mesenchimal stem cells;   Biological: 100 million Bone marrow mesenchimal stem cells
Sponsor:   Clinica Universidad de Navarra, Universidad de Navarra
Completed


Survey of Osteoarthritis Real World Therapies (MK-0663-140)


Condition:   Osteoarthritis
Intervention:   Drug: Standard of care for treatment of osteoarthritis (OA) of knee(s)
Sponsor:   Merck Sharp & Dohme Corp.
Completed


Feasibility Study of Anti-inflammatory Cytokines in Whole Blood in Osteoarthritis Patients


Condition:   Osteoarthritis
Intervention:  
Sponsor:   Zimmer Biomet
Completed

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