About Menopause Clinical Trials (Click to Open)

Join Clinical Trials for Menopause

Menopause Clinical TrialsGeneral Purpose:

Menopause is an exciting time in a woman’s life, but it comes with a host of uncomfortable symptoms that can negatively impact activities of daily living. Around two million women undergo menopause each year, and many ponder the benefit of taking hormone replacement therapy and other alternative treatment measures to help alleviate the symptoms associated with this major life change.

Clinical research is attempting to evaluate interventional methods for improving the quality of life of women during menopause. Such interventions may include alternative treatments like herbal supplements, medications, and behavioral programs.

If you are suffering from the symptoms brought on by menopause (climacteric symptoms), participating in a clinical trial is an excellent way to find an improved approach to living well with menopause and to positively impact the lives of other women who are currently going through, or have yet to undergo, menopause.

What will Menopause/Hot Flashes Clinical Trials be like?

Clinical trials for menopause and the associated symptoms will conduct screenings of each potential participant, which may include a physical exam, medical history, and clinical assessment of your symptoms.

Inclusion criteria are also put in place to avoid any risk, which could result if, for example, the trial were assessing a new pharmaceutical treatment that had detrimental interactions with another medication that you are taking.

Researchers understand the great burden of living with menopausal symptoms, so they aim to select participants that will gain a benefit from taking part in the trial, ideally for them and other women struggling with climacteric symptoms.

Since the most effective intervention for menopausal symptoms remains unclear, there is an extensive range of interventional methods beings evaluated. As a result, you must make sure to select a clinical trial that you feel comfortable participating in after reading the informed consent and learning about what it will entail.

This is particularly important in considering a trial that is testing hormonal replacement, as you should be aware of potential side effects and weigh the potential benefits. You might wish to consult your gynecologist before joining a clinical trial to discuss your options.

Typical Menopause/Hot Flashes Clinical Trial Protocol:

Given the inability of many women to find an escape from the uncomfortable symptoms Clinical trials for menopauseassociated with menopause (climacteric symptoms), there is a diverse array of clinical trials attempting to evaluate new interventional methods to improve the quality of life of women undergoing menopause.

Treatment methods may vary from hormone replacement to an alternative medicine approach. Interventional studies will randomly assign you to a group. In this group you will participate in a treatment or a control for comparison purposes. In hormone replacement trials, researchers may attempt to determine the optimal formulation and dosage of such hormones as estrogen and progestin.

Participants will therefore be assigned to different treatment groups based upon varying doses, and their symptoms will be evaluated at specified time points throughout the duration of the study. This information will then be used to compare formulations and doses in terms of their efficacy and safety in treating menopausal symptoms. Participants may be asked to self-report on their symptoms during the trial by using a standardized questionnaire and rating scale.

Interventional trials testing alternative medicine approaches, such as Chinese Medicine Therapy, will follow a similar outline, with treatment groups receiving an alternative therapy for the purpose of evaluating its efficacy and safety in treating climacteric symptoms.

A behavioral intervention trial may evaluate the benefit of some form of cognitive behavior therapy, such as applied relaxation, on the quality of life of women undergoing menopause. A comparison between standard therapeutic approaches and relaxation may be conducted, or the interventional method may be kept in comparison to a non-treated group.

These trials may ask women to report on their quality of life at specified time points during the treatment, as well as to keep diaries of symptoms including hot flashes. The trial will attempt to determine the most effective intervention for improving the climacteric symptoms that impact your quality of life.

Moreover, joining a clinical trial of this nature will give you access to new interventional methods that are not yet available, so there are many potential benefits of participating in clinical trials on menopause.

Suggested Search Terms:

Climacteric Symptoms and Menopause, Hormone Replacement Therapy for Menopausal Women, Alternative Medicine Approaches to Menopausal Symptoms, Interventional Methods for Treating Hot Flashes, Improving the Quality of Life for Women Undergoing Menopause

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Vortioxetine for Menopausal Depression

Conditions:   Depression;   Menopause;   Vasomotor Disturbance;   Hot Flashes;   Sleep
Intervention:   Drug: vortioxetine
Sponsors:   Massachusetts General Hospital;   Takeda Pharmaceuticals North America, Inc.
Not yet recruiting - verified December 2014

Klimadynon® in Comparison to Conjugated Oestrogens in Women Suffering From Menopausal Complaints

Condition:   Menopause
Interventions:   Drug: Low dose of Klimadynon®;   Drug: Medium dose of Klimadynon®;   Drug: High dose of Klimadynon®;   Drug: Oestrofeminal®;   Drug: Placebo
Sponsor:   Boehringer Ingelheim
Completed - verified July 2014

Black Cohosh Extract for Treatment of Moderate to Severe Menopausal Symptoms

Conditions:   Menopause;   Quality of Life
Interventions:   Drug: black cohosh extract;   Drug: Placebo
Sponsor:   Navamindradhiraj University
Recruiting - verified September 2014

Comparison Between Hand-acupuncture and Electro-acupuncture Stimulation in the Treatment of Menopause

Conditions:   Menopause;   Puncture Site Reaction
Interventions:   Behavioral: Hand-acupuncture;   Device: Electrico-acupuncture
Sponsors:   The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine;   The Affiliated Hospital of the Chinese Academy of Military Medical Sciences
Recruiting - verified March 2014

Cognitive Behavioral Therapy for Insomnia and Nocturnal Hot Flashes in Menopause

Conditions:   Menopause;   Insomnia;   Hot Flashes
Intervention:   Behavioral: Cognitive Behavioral Therapy for Menopausal Insomnia (CBTMI)
Sponsors:   The University of Texas, Galveston;   National Institutes of Health (NIH);   National Institute of Nursing Research (NINR)
Not yet recruiting - verified December 2014

A Comparison of Farabloc Fabric With Placebo on Alleviation Hot Flash in Menopausal Women

Condition:   Menopause
Interventions:   Device: Farabloc;   Device: Nylon Fabric
Sponsor:   University of British Columbia
Recruiting - verified June 2014

LDX and Functional Magnetic Resonance Imaging (fMRI in Menopausal Women

Conditions:   Menopause;   Brain Activity;   Cognition
Intervention:   Drug: Lisdexamfetamine
Sponsors:   University of Pennsylvania;   Shire
Completed - verified May 2014

The LADIES Acute Coronary Syndromes Study

Conditions:   Acute Coronary Syndromes;   Menopause
Sponsor:   Arcispedale Santa Maria Nuova-IRCCS
Recruiting - verified April 2014

MsFLASH-04: Pilot Trial: Telephone Behavioral Therapy for Menopause-related Sleep Disturbance

Conditions:   Hot Flashes;   Menopause;   Vasomotor Disturbance;   Sleep
Intervention:   Behavioral: Cognitive Behavioral Therapy-Insomnia (CBT-I)
Sponsors:   Fred Hutchinson Cancer Research Center;   National Institute on Aging (NIA)
Active, not recruiting - verified February 2015

Effects of Yoga on Menopausal Symptoms in Women With Breast Cancer

Conditions:   Menopause;   Breast Cancer
Interventions:   Behavioral: Yoga;   Other: Usual care
Sponsor:   Universität Duisburg-Essen
Completed - verified July 2014

Isoflavones and Magnolia Extract in the Quality of Life in Menopausal Women

Condition:   Menopause
Intervention:   Dietary Supplement: isoflavones combined with magnolia
Sponsor:   Rottapharm Spain
Completed - verified November 2014

Alternative Treatments for Menopausal Women

Conditions:   Menopause;   Hot Flushes;   Osteoporosis;   Dyslipidemia
Interventions:   Dietary Supplement: Placebo;   Dietary Supplement: Red Clover extract
Sponsor:   Aarhus University Hospital
Completed - verified February 2015

Therapy to Prevent Sexual Pain in Breast Cancer Survivors

Conditions:   Vulvodynia;   Dyspareunia;   Breast Cancer;   Menopause
Intervention:   Drug: Topical liquid lidocaine
Sponsor:   Oregon Health and Science University
Completed - verified May 2014

MsFLASH-03: Comparative Efficacy of Low-Dose Estradiol and Venlafaxine XR for Treatment of Menopausal Symptoms

Conditions:   Hot Flashes;   Menopause;   Vasomotor Disturbance
Interventions:   Drug: Low-dose 17-ß-estradiol with progesterone taper;   Drug: Venlafaxine XR;   Drug: Placebo
Sponsors:   Fred Hutchinson Cancer Research Center;   National Institute on Aging (NIA);   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Center for Complementary and Integrative Health (NCCIH);   Office of Research on Women's Health (ORWH)
Completed - verified August 2014

Pheno- & Genotyping POF (WHO III)

Conditions:   Premature Ovarian Failure (POF);   Incipient Ovarian Failure;   Poor Response After Ovarian Hyperstimulation;   Early Menopause;   Hypergonadotropic Amenorrhea
Sponsors:   UMC Utrecht;   Erasmus Medical Center;   Medical Center Alkmaar;   University Medical Centre Groningen;   Leiden University Medical Center;   Medisch Spectrum Twente;   Isala;   Department of Clinical Pharmacy, University Medical Centre St Radboud, The Netherlands.;   Amphia Hospital;   Deventer Ziekenhuis;   Catharina Ziekenhuis Eindhoven;   Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA);   Academisch Ziekenhuis Maastricht;   VU University Medical Center
Recruiting - verified February 2015

Attention & Memory Impairments in Menopausal Women

Conditions:   Symptomatic Menopause;   Cognitive Impairments
Intervention:   Drug: Lisdexamfetamine
Sponsors:   University of Pennsylvania;   Shire
Completed - verified May 2014

Climacteric Therapy With Applied Relaxation Using InterNet

Conditions:   Hot Flashes;   Menopause
Intervention:   Behavioral: Applied relaxation
Sponsors:   Mats Hammar;   Linkoeping University
Terminated - verified April 2014

MsFLASH-02: Interventions for Relief of Menopausal Symptoms: A 3-by-2 Factorial Design Examining Yoga, Exercise, and Omega-3 Supplementation

Conditions:   Hot Flashes;   Menopause;   Vasomotor Symptoms
Interventions:   Dietary Supplement: Placebo;   Dietary Supplement: Omega-3;   Behavioral: Yoga;   Behavioral: Exercise;   Behavioral: Usual Activity
Sponsors:   Fred Hutchinson Cancer Research Center;   National Institute on Aging (NIA);   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Center for Complementary and Integrative Health (NCCIH);   Office of Research on Women's Health (ORWH);   Nordic Naturals
Completed - verified August 2014

Duloxetine for Menopausal Depression

Conditions:   Depression;   Menopause;   Vasomotor Symptoms
Intervention:   Drug: Duloxetine
Sponsor:   Massachusetts General Hospital
Completed - verified August 2014

Research Investigation of Soy and Estrogen

Conditions:   Menopause;   Hot Flashes
Interventions:   Dietary Supplement: Phytoestrogen;   Drug: Estradiol;   Drug: medroxyprogesterone acetate;   Other: Placebo;   Other: Placebo
Sponsors:   University of Illinois at Chicago;   National Institute of Mental Health (NIMH)
Recruiting - verified May 2014

Following Lipectomy to Understand Adipose Tissue Re-accumulation

Conditions:   Menopause;   Pre-menopause
Intervention:   Procedure: Femoral lipectomy
Sponsor:   University of Colorado, Denver
Completed - verified December 2014

Organochlorine Exposure in Relation to Timing of Natural Menopause

Condition:   Menopause
Sponsor:   National Institute of Environmental Health Sciences (NIEHS)
Completed - verified July 2014

Menopause and Meditation for Breast Cancer Survivors

Condition:   Menopause
Intervention:   Behavioral: Mindfulness Meditation
Sponsors:   University of Pittsburgh;   National Institutes of Health (NIH)
Completed - verified December 2014

Study of the Efficacy of ESTRATEST® H.S. Tablets in Relieving Menopausal Symptoms in Estrogenized Postmenopausal Women

Condition:   Menopause
Intervention:   Drug: esterified estrogens 0.625 mg and methyltestosterone 1.25 mg
Sponsor:   Solvay Pharmaceuticals
Completed - verified January 2009

Does Menopause Matter?

Condition:   Menopause
Sponsors:   University of Pittsburgh;   National Institute on Aging (NIA);   National Center for Complementary and Integrative Health (NCCIH)
Completed - verified May 2014

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