Menopause

About Menopause Clinical Trials (Click to Open)

Join Clinical Trials for Menopause

Menopause Clinical TrialsGeneral Purpose:

Menopause is an exciting time in a woman’s life, but it comes with a host of uncomfortable symptoms that can negatively impact activities of daily living. Around two million women undergo menopause each year, and many ponder the benefit of taking hormone replacement therapy and other alternative treatment measures to help alleviate the symptoms associated with this major life change.

Clinical research is attempting to evaluate interventional methods for improving the quality of life of women during menopause. Such interventions may include alternative treatments like herbal supplements, medications, and behavioral programs.

If you are suffering from the symptoms brought on by menopause (climacteric symptoms), participating in a clinical trial is an excellent way to find an improved approach to living well with menopause and to positively impact the lives of other women who are currently going through, or have yet to undergo, menopause.

What will Menopause/Hot Flashes Clinical Trials be like?

Clinical trials for menopause and the associated symptoms will conduct screenings of each potential participant, which may include a physical exam, medical history, and clinical assessment of your symptoms.

Inclusion criteria are also put in place to avoid any risk, which could result if, for example, the trial were assessing a new pharmaceutical treatment that had detrimental interactions with another medication that you are taking.

Researchers understand the great burden of living with menopausal symptoms, so they aim to select participants that will gain a benefit from taking part in the trial, ideally for them and other women struggling with climacteric symptoms.

Since the most effective intervention for menopausal symptoms remains unclear, there is an extensive range of interventional methods beings evaluated. As a result, you must make sure to select a clinical trial that you feel comfortable participating in after reading the informed consent and learning about what it will entail.

This is particularly important in considering a trial that is testing hormonal replacement, as you should be aware of potential side effects and weigh the potential benefits. You might wish to consult your gynecologist before joining a clinical trial to discuss your options.

Typical Menopause/Hot Flashes Clinical Trial Protocol:

Given the inability of many women to find an escape from the uncomfortable symptoms Clinical trials for menopauseassociated with menopause (climacteric symptoms), there is a diverse array of clinical trials attempting to evaluate new interventional methods to improve the quality of life of women undergoing menopause.

Treatment methods may vary from hormone replacement to an alternative medicine approach. Interventional studies will randomly assign you to a group. In this group you will participate in a treatment or a control for comparison purposes. In hormone replacement trials, researchers may attempt to determine the optimal formulation and dosage of such hormones as estrogen and progestin.

Participants will therefore be assigned to different treatment groups based upon varying doses, and their symptoms will be evaluated at specified time points throughout the duration of the study. This information will then be used to compare formulations and doses in terms of their efficacy and safety in treating menopausal symptoms. Participants may be asked to self-report on their symptoms during the trial by using a standardized questionnaire and rating scale.

Interventional trials testing alternative medicine approaches, such as Chinese Medicine Therapy, will follow a similar outline, with treatment groups receiving an alternative therapy for the purpose of evaluating its efficacy and safety in treating climacteric symptoms.

A behavioral intervention trial may evaluate the benefit of some form of cognitive behavior therapy, such as applied relaxation, on the quality of life of women undergoing menopause. A comparison between standard therapeutic approaches and relaxation may be conducted, or the interventional method may be kept in comparison to a non-treated group.

These trials may ask women to report on their quality of life at specified time points during the treatment, as well as to keep diaries of symptoms including hot flashes. The trial will attempt to determine the most effective intervention for improving the climacteric symptoms that impact your quality of life.

Moreover, joining a clinical trial of this nature will give you access to new interventional methods that are not yet available, so there are many potential benefits of participating in clinical trials on menopause.

Suggested Search Terms:

Climacteric Symptoms and Menopause, Hormone Replacement Therapy for Menopausal Women, Alternative Medicine Approaches to Menopausal Symptoms, Interventional Methods for Treating Hot Flashes, Improving the Quality of Life for Women Undergoing Menopause

Current Search Term:

Menopause

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Impact of Egg Consumption on Carotenoid and Vitamin D Bioavailability in Pre- and Post-menopausal Women


Condition:   Menopause
Intervention:   Behavioral: Egg consumption
Sponsor:   Purdue University
Recruiting - verified February 2016


Internet-based Cognitive Behavioral Therapy for Breast Cancer Patients With Climacteric Symptoms


Conditions:   Climacteric Symptoms;   Breast Cancer Survivors
Intervention:   Behavioral: EVA-Online
Sponsors:   The Netherlands Cancer Institute;   Dutch Cancer Society
Recruiting - verified January 2016


Assessing the Value of Red Grapes Polyphenol Supplementation on Metabolic Parameters in Obese Insulinoresistant Menopausal Women


Conditions:   Obesity;   Insulin Resistance;   Menopause
Intervention:   Other: Supplementation with red grapes polyphenol
Sponsors:   University Hospital, Montpellier;   Institut National de la Santé Et de la Recherche Médicale, France
Recruiting - verified December 2015


MENOS@Work Trial: A Self-help CBT Intervention for Working Women


Condition:   Menopause
Intervention:   Behavioral: self-help CBT intervention (SHCBT)
Sponsors:   King's College London;   University of Nottingham;   Wellbeing of Women
Recruiting - verified December 2015


Menopausal Health Training for Husbands on Women's Quality of Life and Marital Satisfaction


Condition:   Menopause
Intervention:   Other: Training program about menopausal health isues
Sponsors:   Gonabad University of Medical Sciences;   Shahid Sadoughi University of Medical Sciences and Health Services
Completed - verified July 2015


A Study To Investigate The Effect Of A Natural Dietary Supplement On Peri-Menopausal Symptoms


Condition:   Menopause
Intervention:   Dietary Supplement: proprietary formula
Sponsor:   Physician Recommended Nutriceuticals
Suspended - verified January 2016


Electro-acupuncture for Menopausal Transition Symptoms


Condition:   Menopause
Interventions:   Device: Eelectro-acupuncture;   Device: Sham Eelectro-acupuncture
Sponsor:   Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Completed - verified October 2015


Raising Insulin Sensitivity in Post Menopause


Condition:   Menopause
Interventions:   Drug: TSEC (Tissue-selective estrogen complexes);   Other: Placebo
Sponsor:   Pennington Biomedical Research Center
Recruiting - verified December 2015


A Clinical Trial on the Efficacy of a Combination Herbal Product, Biotropics' Nu Femme, on Menopausal Symptoms and Quality of Life in Women


Condition:   Menopausal Symptoms
Interventions:   Dietary Supplement: Nu Femme;   Other: Placebo
Sponsors:   KGK Synergize Inc.;   Biotropics Malaysia Berhad
Recruiting - verified December 2015


Vortioxetine for Menopausal Depression


Conditions:   Depression;   Menopause;   Vasomotor Disturbance;   Hot Flashes;   Sleep
Intervention:   Drug: vortioxetine
Sponsors:   Massachusetts General Hospital;   Takeda Pharmaceuticals North America, Inc.
Recruiting - verified October 2015


Comparison Between Hand-acupuncture and Electro-acupuncture Stimulation in the Treatment of Menopause


Conditions:   Menopause;   Puncture Site Reaction
Interventions:   Behavioral: Hand-acupuncture;   Device: Electrico-acupuncture
Sponsors:   The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine;   The Affiliated Hospital of the Chinese Academy of Military Medical Sciences
Completed - verified March 2014


Effects of a Kappa Agonist on Hot Flashes in Menopausal Women


Condition:   Treatment of Menopausal Hot Flashes
Interventions:   Drug: Standard Dose Kappa Agonist;   Drug: Half Dose Kappa Agonist;   Other: Placebo
Sponsors:   University of Washington;   National Institute on Aging (NIA);   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Center for Complementary and Integrative Health (NCCIH);   Office of Research and Women's Health (ORWH);   National Center for Advancing Translational Science (NCATS)
Completed - verified June 2015


Cognitive Behavioral Therapy for Insomnia and Nocturnal Hot Flashes in Menopause


Conditions:   Menopause;   Insomnia;   Hot Flashes
Intervention:   Behavioral: CBT for Menopausal Insomnia (CBTMI)
Sponsors:   The University of Texas Medical Branch, Galveston;   National Institutes of Health (NIH);   National Institute of Nursing Research (NINR)
Recruiting - verified September 2015


Efficacy and Safety of Sage Tablets Compared to Placebo in Menopausal Patients With Hot Flushes and Sweating


Condition:   Menopausal Hot Flushes
Intervention:   Drug: Sage extract, 3400 mg , DER 1:17
Sponsor:   Bioforce AG
Terminated - verified July 2015


The LADIES Acute Coronary Syndromes Study


Conditions:   Acute Coronary Syndromes;   Menopause
Intervention:  
Sponsor:   Arcispedale Santa Maria Nuova-IRCCS
Completed - verified December 2015


MsFLASH-04: Pilot Trial: Telephone Behavioral Therapy for Menopause-related Sleep Disturbance


Conditions:   Hot Flashes;   Menopause;   Vasomotor Disturbance;   Sleep
Interventions:   Behavioral: Cognitive Behavioral Therapy-Insomnia (CBT-I);   Behavioral: Menopause Education Control (MEC)
Sponsors:   Fred Hutchinson Cancer Research Center;   National Institute on Aging (NIA)
Completed - verified October 2015


Behavioral Treatment of Menopausal Insomnia; Sleep and Daytime Outcomes


Condition:   Menopause
Interventions:   Behavioral: Cognitive Behavioral Therapy for Insomnia;   Behavioral: Sleep Education;   Behavioral: Sleep Restriction Therapy
Sponsors:   Christopher Drake;   National Institute of Nursing Research (NINR);   Wayne State University;   University of Michigan
Recruiting - verified August 2015


Therapy to Prevent Sexual Pain in Breast Cancer Survivors


Conditions:   Vulvodynia;   Dyspareunia;   Breast Cancer;   Menopause
Interventions:   Drug: Topical liquid lidocaine;   Drug: Topical saline
Sponsor:   OHSU Knight Cancer Institute
Completed - verified July 2015


Pheno- & Genotyping POF (WHO III)


Conditions:   Premature Ovarian Failure (POF);   Incipient Ovarian Failure;   Poor Response After Ovarian Hyperstimulation;   Early Menopause;   Hypergonadotropic Amenorrhea
Intervention:  
Sponsors:   UMC Utrecht;   Erasmus Medical Center;   Medical Center Alkmaar;   University Medical Center Groningen;   Leiden University Medical Center;   Medisch Spectrum Twente;   Isala;   Department of Clinical Pharmacy, University Medical Centre St Radboud, The Netherlands.;   Amphia Hospital;   Deventer Ziekenhuis;   Catharina Ziekenhuis Eindhoven;   Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA);   Academisch Ziekenhuis Maastricht;   VU University Medical Center
Recruiting - verified December 2015


Research Investigation of Soy and Estrogen


Conditions:   Menopause;   Hot Flashes
Interventions:   Dietary Supplement: Phytoestrogen;   Drug: Estradiol;   Drug: medroxyprogesterone acetate;   Other: Placebo;   Other: Placebo
Sponsors:   University of Illinois at Chicago;   National Institute of Mental Health (NIMH)
Completed - verified July 2015


Effect of Exercise and Phytoestrogen on Bone, Metabolic Syndrome Criteria and Complaints of the Early Menopause


Conditions:   Bone Diseases;   Metabolic Syndrome X;   Coronary Disease
Interventions:   Behavioral: exercise;   Behavioral: exercise + cimicifuga racemosa;   Behavioral: wellness control, placebo
Sponsors:   University of Erlangen-Nürnberg Medical School;   Siemens-Betriebskrankenkasse
Terminated - verified May 2015


Healthy Transitions: Menopause Effect on Obesity, Energy Balance, and Insulin


Condition:   Menopause
Intervention:  
Sponsors:   Pennington Biomedical Research Center;   National Institutes of Health (NIH)
Completed - verified January 2016


Organochlorine Exposure in Relation to Timing of Natural Menopause


Condition:   Menopause
Intervention:  
Sponsor:   National Institute of Environmental Health Sciences (NIEHS)
Completed - verified June 2015


Effects of Soy Isoflavones on Menopausal Hot Flashes


Condition:   Menopausal Symptoms
Intervention:   Drug: Isoflavone supplement
Sponsors:   Beth Israel Deaconess Medical Center;   Nichimo - Tokyo, Japan
Completed - verified November 2015


Longitudinal Study of the Menopause and Fat Patterning


Conditions:   Cardiovascular Diseases;   Menopause;   Heart Diseases
Intervention:  
Sponsors:   Rush University Medical Center;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified October 2015

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