Menopause

About Menopause Clinical Trials (Click to Open)

Join Clinical Trials for Menopause

Menopause Clinical TrialsGeneral Purpose:

Menopause is an exciting time in a woman’s life, but it comes with a host of uncomfortable symptoms that can negatively impact activities of daily living. Around two million women undergo menopause each year, and many ponder the benefit of taking hormone replacement therapy and other alternative treatment measures to help alleviate the symptoms associated with this major life change.

Clinical research is attempting to evaluate interventional methods for improving the quality of life of women during menopause. Such interventions may include alternative treatments like herbal supplements, medications, and behavioral programs.

If you are suffering from the symptoms brought on by menopause (climacteric symptoms), participating in a clinical trial is an excellent way to find an improved approach to living well with menopause and to positively impact the lives of other women who are currently going through, or have yet to undergo, menopause.

What will Menopause/Hot Flashes Clinical Trials be like?

Clinical trials for menopause and the associated symptoms will conduct screenings of each potential participant, which may include a physical exam, medical history, and clinical assessment of your symptoms.

Inclusion criteria are also put in place to avoid any risk, which could result if, for example, the trial were assessing a new pharmaceutical treatment that had detrimental interactions with another medication that you are taking.

Researchers understand the great burden of living with menopausal symptoms, so they aim to select participants that will gain a benefit from taking part in the trial, ideally for them and other women struggling with climacteric symptoms.

Since the most effective intervention for menopausal symptoms remains unclear, there is an extensive range of interventional methods beings evaluated. As a result, you must make sure to select a clinical trial that you feel comfortable participating in after reading the informed consent and learning about what it will entail.

This is particularly important in considering a trial that is testing hormonal replacement, as you should be aware of potential side effects and weigh the potential benefits. You might wish to consult your gynecologist before joining a clinical trial to discuss your options.

Typical Menopause/Hot Flashes Clinical Trial Protocol:

Given the inability of many women to find an escape from the uncomfortable symptoms Clinical trials for menopauseassociated with menopause (climacteric symptoms), there is a diverse array of clinical trials attempting to evaluate new interventional methods to improve the quality of life of women undergoing menopause.

Treatment methods may vary from hormone replacement to an alternative medicine approach. Interventional studies will randomly assign you to a group. In this group you will participate in a treatment or a control for comparison purposes. In hormone replacement trials, researchers may attempt to determine the optimal formulation and dosage of such hormones as estrogen and progestin.

Participants will therefore be assigned to different treatment groups based upon varying doses, and their symptoms will be evaluated at specified time points throughout the duration of the study. This information will then be used to compare formulations and doses in terms of their efficacy and safety in treating menopausal symptoms. Participants may be asked to self-report on their symptoms during the trial by using a standardized questionnaire and rating scale.

Interventional trials testing alternative medicine approaches, such as Chinese Medicine Therapy, will follow a similar outline, with treatment groups receiving an alternative therapy for the purpose of evaluating its efficacy and safety in treating climacteric symptoms.

A behavioral intervention trial may evaluate the benefit of some form of cognitive behavior therapy, such as applied relaxation, on the quality of life of women undergoing menopause. A comparison between standard therapeutic approaches and relaxation may be conducted, or the interventional method may be kept in comparison to a non-treated group.

These trials may ask women to report on their quality of life at specified time points during the treatment, as well as to keep diaries of symptoms including hot flashes. The trial will attempt to determine the most effective intervention for improving the climacteric symptoms that impact your quality of life.

Moreover, joining a clinical trial of this nature will give you access to new interventional methods that are not yet available, so there are many potential benefits of participating in clinical trials on menopause.

Suggested Search Terms:

Climacteric Symptoms and Menopause, Hormone Replacement Therapy for Menopausal Women, Alternative Medicine Approaches to Menopausal Symptoms, Interventional Methods for Treating Hot Flashes, Improving the Quality of Life for Women Undergoing Menopause

Current Search Term:

Menopause

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Efficacy Study of Progesterone Tablet in Post-menopausal Women


Condition:   Menopause
Intervention:   Drug: Progesterone
Sponsor:   IBSA Institut Biochimique SA
Recruiting - verified July 2016


Lacto-ovo-vegetarian Diet Riched in Omega-3 Fatty Acids in Menopausal Women


Conditions:   Menopause;   Metabolic Syndrome;   Hepatic Steatosis
Interventions:   Other: Diet rich in omega-3 fatty acids;   Other: Diet with extra virgin olive oil
Sponsor:   Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Enrolling by invitation - verified June 2016


Study to Evaluate the Effects of the Cooling Bolero in Women With Common Menopause Symptoms


Condition:   Menopause Symptoms
Intervention:   Device: Cooling Bolero
Sponsors:   Englewood Hospital and Medical Center;   Nanohealth, Inc.
Recruiting - verified July 2016


Dose-response Study of Carduus Marianus in Centesimal Scale for Dyslipidemia in Climacteric Overweighed or Obese Women.


Conditions:   Dyslipidemia;   Menopause;   Obesity
Interventions:   Drug: Carduus marianus 6cH;   Drug: Carduus marianus 12cH;   Drug: Carduus marianus 30cH;   Drug: Placebo;   Behavioral: Exercise;   Other: Diet
Sponsors:   Hospital Nacional Homeopático, Mexico;   Laboratorio Similia, México
Recruiting - verified May 2016


Sulpiride Versus Placebo for Reducting Hot Flushes During Climacteric


Conditions:   Menopausal Syndrome;   Hot Flashes
Interventions:   Drug: Sulpiride use;   Drug: Placebo
Sponsor:   Hospital de Clinicas de Porto Alegre
Recruiting - verified April 2016


The Efficacy of ACupuncture On Menopausal Symptoms (ACOM)


Condition:   Menopause
Intervention:   Procedure: Acupuncture
Sponsors:   University of Copenhagen;   Section of General Practice, University of Copenhagen;   Research Unit Of General Practice, Copenhagen;   Danish Society for Evidence Based Acupuncture (DSEA);   Idella Foundation;   University of Southern Denmark
Not yet recruiting - verified June 2016


A TSEC for Symptom Management in Menopausal Women With Multiple Sclerosis


Conditions:   Menopause;   Multiple Sclerosis
Interventions:   Drug: Tissue Selective Estrogen Complex;   Drug: Placebo
Sponsors:   University of California, San Francisco;   National Multiple Sclerosis Society
Recruiting - verified March 2016


Evaluation of Periodontal Response to Non Surgical Therapy in Pre and Post Menopausal Women With Periodontitis


Conditions:   Periodontitis;   Menopause;   Plaque;   Inflammation
Intervention:   Other: scaling and root planing (srp)
Sponsor:   Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Completed - verified March 2016


Comparison of Vaginal Laser Therapy to Vaginal Estrogen Therapy


Conditions:   Atrophic Vaginitis;   Menopause
Interventions:   Device: CO2 fractionated vaginal laser;   Drug: Estrogens, Conjugated (USP)
Sponsors:   The Cleveland Clinic;   Foundation for Female Health Awareness
Recruiting - verified June 2016


Impact of Egg Consumption on Carotenoid and Vitamin D Bioavailability in Pre- and Post-menopausal Women


Condition:   Menopause
Interventions:   Behavioral: Egg consumption;   Behavioral: Control
Sponsor:   Purdue University
Recruiting - verified March 2016


Internet-based Cognitive Behavioral Therapy for Breast Cancer Patients With Climacteric Symptoms


Conditions:   Climacteric Symptoms;   Breast Cancer Survivors
Intervention:   Behavioral: EVA-Online
Sponsors:   The Netherlands Cancer Institute;   Dutch Cancer Society
Recruiting - verified January 2016


Assessing the Value of Red Grapes Polyphenol Supplementation on Metabolic Parameters in Obese Insulinoresistant Menopausal Women


Conditions:   Obesity;   Insulin Resistance;   Menopause
Intervention:   Other: Supplementation with red grapes polyphenol
Sponsors:   University Hospital, Montpellier;   Institut National de la Santé Et de la Recherche Médicale, France
Recruiting - verified December 2015


A Study To Investigate The Effect Of A Natural Dietary Supplement On Peri-Menopausal Symptoms


Condition:   Menopause
Intervention:   Dietary Supplement: proprietary formula
Sponsor:   Physician Recommended Nutriceuticals
Suspended - verified January 2016


Electro-acupuncture for Menopausal Transition Symptoms


Condition:   Menopause
Interventions:   Device: Eelectro-acupuncture;   Device: Sham Eelectro-acupuncture
Sponsor:   Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Completed - verified October 2015


A Clinical Trial on the Efficacy of a Combination Herbal Product, Biotropics' Nu Femme, on Menopausal Symptoms and Quality of Life in Women


Condition:   Menopausal Symptoms
Interventions:   Dietary Supplement: Nu Femme;   Other: Placebo
Sponsors:   KGK Synergize Inc.;   Biotropics Malaysia Berhad
Recruiting - verified December 2015


Vortioxetine for Menopausal Depression


Conditions:   Depression;   Menopause;   Vasomotor Disturbance;   Hot Flashes;   Sleep
Intervention:   Drug: vortioxetine
Sponsors:   Massachusetts General Hospital;   Takeda Pharmaceuticals North America, Inc.
Recruiting - verified March 2016


Comparison Between Hand-acupuncture and Electro-acupuncture Stimulation in the Treatment of Menopause


Conditions:   Menopause;   Puncture Site Reaction
Interventions:   Behavioral: Hand-acupuncture;   Device: Electrico-acupuncture
Sponsors:   The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine;   The Affiliated Hospital of the Chinese Academy of Military Medical Sciences
Completed - verified March 2014


Cognitive Behavioral Therapy for Insomnia and Nocturnal Hot Flashes in Menopause


Conditions:   Menopause;   Insomnia;   Hot Flashes
Intervention:   Behavioral: CBT for Menopausal Insomnia (CBTMI)
Sponsors:   The University of Texas Medical Branch, Galveston;   National Institutes of Health (NIH);   National Institute of Nursing Research (NINR)
Recruiting - verified March 2016


The LADIES Acute Coronary Syndromes Study


Conditions:   Acute Coronary Syndromes;   Menopause
Intervention:  
Sponsor:   Arcispedale Santa Maria Nuova-IRCCS
Completed - verified December 2015


MsFLASH-04: Pilot Trial: Telephone Behavioral Therapy for Menopause-related Sleep Disturbance


Conditions:   Hot Flashes;   Menopause;   Vasomotor Disturbance;   Sleep
Interventions:   Behavioral: Cognitive Behavioral Therapy-Insomnia (CBT-I);   Behavioral: Menopause Education Control (MEC)
Sponsors:   Fred Hutchinson Cancer Research Center;   National Institute on Aging (NIA)
Completed - verified October 2015


Behavioral Treatment of Menopausal Insomnia; Sleep and Daytime Outcomes


Condition:   Menopause
Interventions:   Behavioral: Cognitive Behavioral Therapy for Insomnia;   Behavioral: Sleep Education;   Behavioral: Sleep Restriction Therapy
Sponsors:   Christopher Drake;   National Institute of Nursing Research (NINR);   Wayne State University;   University of Michigan
Recruiting - verified August 2015


Pheno- & Genotyping POF (WHO III)


Conditions:   Premature Ovarian Failure (POF);   Incipient Ovarian Failure;   Poor Response After Ovarian Hyperstimulation;   Early Menopause;   Hypergonadotropic Amenorrhea
Intervention:  
Sponsors:   UMC Utrecht;   Erasmus Medical Center;   Medical Center Alkmaar;   University Medical Center Groningen;   Leiden University Medical Center;   Medisch Spectrum Twente;   Isala;   Department of Clinical Pharmacy, University Medical Centre St Radboud, The Netherlands.;   Amphia Hospital;   Deventer Ziekenhuis;   Catharina Ziekenhuis Eindhoven;   Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA);   Academisch Ziekenhuis Maastricht;   VU University Medical Center
Recruiting - verified December 2015


Healthy Transitions: Menopause Effect on Obesity, Energy Balance, and Insulin


Condition:   Menopause
Intervention:  
Sponsors:   Pennington Biomedical Research Center;   National Institutes of Health (NIH)
Completed - verified January 2016


Organochlorine Exposure in Relation to Timing of Natural Menopause


Condition:   Menopause
Intervention:  
Sponsor:   National Institute of Environmental Health Sciences (NIEHS)
Completed - verified June 2016


Effects of Soy Isoflavones on Menopausal Hot Flashes


Condition:   Menopausal Symptoms
Intervention:   Drug: Isoflavone supplement
Sponsors:   Beth Israel Deaconess Medical Center;   Nichimo - Tokyo, Japan
Completed - verified November 2015

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