Depression

About Depression Clinical Trials (Click to Open)

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General Purpose:

Clinical Trials for DepressionLiving with depression can negatively impact all aspects of your life. While current treatments help some patients, not all are able to benefit from them. Clinical trials for depression are trying to bridge the gap in treatment so that there is hope for each and every patient.

Past research indicates that genes may contribute to the efficacy of antidepressants. Current clinical trials are therefore trying to decipher the effect that genes have on an individual’s response to treatment, which will facilitate improved treatment methods.

The role of glutamate levels in the brain is another key focus of depression research, as glutamate tends to be reduced in the brains of those with depression. Studies would now like to evaluate how various antidepressants affect glutamate levels in the brain.

Other trials may assess the benefit of different behavioral interventions, such as combined psychotherapy and illness management. In addition to efficacy trials, there are also many observational trials intending to develop new techniques to characterize the physiological changes that are indicative of depression.

Such studies will enhance the ability to assess the effects that depression has on patients, to improve the ability to treat depression.

What are Clinical Trials for Depression like?

Clinical trials for depression will conduct screenings of each potential participant, which may include a physical exam, medical history, and blood and urine tests. You will be asked to report on your mood, feelings of depression, and any family history of depression.Clinical Trials for Depression

Depending on the specific trial, the study doctor may request additional tests for each individual. The goal is to ensure that you are the proper fit for a trial. Researchers understand the impedance of living with depression, so they aim to select participants that will gain a benefit from taking part in the trial, ideally for them and other patients struggling with this detrimental condition.

Inclusion criteria are intended to provide benefit and avoid wasting your time. They are also put in place to avoid any risk, which could result if, for example, the trial were assessing a new pharmaceutical treatment that had detrimental interactions with another medication that you are taking.

Typical Trial Protocol for Clinical Trials for Depression:

Interventional studies will vary depending upon the form of depression, such as major depressive disorder (MDD), depression related to pregnancy, depression in geriatric populations, etc.

Clinical Trials for Depression:Clinical trials for MDD will likely provide treatment groups with an antidepressant for one leg of the trial, during which time they will systematically be assessed through questionnaires and clinician reports to evaluate any changes in the symptoms.

Other parts of these trials may include physiological assessment, with such techniques as magnetic resonance imaging (MRI) or magnetic resonance spectroscopy (MRS). Clinical trials for depression during and after pregnancy may involve some form of behavioral intervention, such as psychotherapy.

Depression is one of the most common complications during pregnancy, and it can have detrimental health effects not only on the mother, but also on the baby. These trials are therefore integral to ensuring a healthy life for babies of mothers suffering from depression, particularly because it is quite hard to diagnose due to the overlap with typical pregnancy symptoms.

Participants in these trials will be assigned to interpersonal psychotherapy throughout pregnancy and in the months following, with periodic evaluations. Clinical trials targeting depression among an elderly population often employ behavioral interventions, such as illness management.

Participants will be assigned to different management programs or psychotherapy groups, with symptom assessments scheduled at specific time intervals. Some clinical trials are meant specifically for healthy individuals without any history of depressive disorders, intended to develop new diagnostic assessments to better understand this illness. Studies of this nature will likely assign healthy participants to different technique groups, such as MRI and neuropsychological testing groups.

Suggested Search Terms:

Genetics and Major Depressive Disorder, Depression and Pregnancy, Treating Depressed Elders, Effects of Psychotherapy on Depression, Development of Magnetic Resonance Imaging Techniques for Depressive Disorders

Current Search Term Used: “Depression”



Creatine Monohydrate Use for Preventing Altitude Induced Depression


Condition:   Depression
Interventions:   Drug: Creatine monohydrate;   Drug: Placebo
Sponsor:   Mike O'Callaghan Military Hospital
Not yet recruiting


PREPP: Preventing Postpartum Depression


Condition:   Postpartum Depression
Interventions:   Behavioral: Practical Resources for Effective Postpartum Parenting;   Behavioral: Enhanced Treatment As Usual
Sponsor:   New York State Psychiatric Institute
Recruiting


NEUROFEEDSTIM : Therapeutic Use of Neurofeedback in Depression in Association With TMS


Condition:   Depression
Intervention:   Device: EEG-neurofeedback training in association with TMS.
Sponsor:   Rennes University Hospital
Not yet recruiting


Sleep and Healthy Aging Research for Depression (SHARE-D) Study


Condition:   Depression in Old Age
Interventions:   Biological: Endotoxin;   Biological: Placebo
Sponsor:   Michael Irwin, MD
Active, not recruiting


EM/PROTECT: Improving Depression in Elder Mistreatment Victims


Condition:   Depression
Interventions:   Behavioral: EM/PROTECT;   Behavioral: EM/MH
Sponsors:   Weill Medical College of Cornell University;   New York City Department for the Aging (DFTA);   National Institute of Mental Health (NIMH)
Recruiting


Depression, Adversity, and Stress Hormones (DASH) Study


Condition:   Depression
Interventions:   Other: Cortisol;   Other: Placebo
Sponsors:   University of Wisconsin, Madison;   National Institute of Mental Health (NIMH);   Brain & Behavior Research Foundation
Completed


Post-natal Depression and Chronic Stress


Condition:   Depression, Postpartum
Intervention:  
Sponsor:   Institut de Recherche Biomedicale des Armees
Recruiting


Brief CBT for the Treatment of Depression During Inpatient Hospitalization


Condition:   Depression
Interventions:   Behavioral: Usual Standard of Care;   Behavioral: Cognitive Behavioral Therapy Condition (CBT)
Sponsor:   New York University School of Medicine
Recruiting


Canadian rTMS Treatment and Biomarker Network in Depression Trial


Condition:   Depression
Intervention:   Device: rTMS
Sponsors:   Centre for Addiction and Mental Health;   University Health Network, Toronto;   University of British Columbia;   Brain Canada
Active, not recruiting


European Comparative Effectiveness Research on Internet-based Depression Treatment in Poland


Condition:   Depression
Interventions:   Behavioral: Blended Cognitive Behavioural Therapy (CBT);   Behavioral: Treatment as usual
Sponsors:   University of Social Sciences and Humanities, Warsaw;   VU University of Amsterdam;   Linkoeping University;   University of Erlangen-Nürnberg;   London School of Hygiene and Tropical Medicine;   Stichting GGZ inGeest;   Universitat Jaume I;   Leuphana Universität Lünenberg;   University of Limerick;   University of Bern;   University of Valencia;   Inesc Porto;   Institut National de la Santé Et de la Recherche Médicale, France;   European Commission;   Ministry of Science and Higher Education, Poland
Active, not recruiting


Using Peer Mentors to Deliver Depression Care


Condition:   Depression
Intervention:   Behavioral: Meetings with peer mentors
Sponsor:   Johns Hopkins University
Completed


Training and Supervision Program for Depression Management


Condition:   Depression
Intervention:   Behavioral: Depression training/supervision program
Sponsor:   University of Chile
Completed


The Use Of L-Methylfolate As A Treatment For Depression


Condition:   Depression
Intervention:   Other: L-methylfolate
Sponsors:   University of Florida;   Pamlab, Inc.
Recruiting


A Family Depression Prevention Program


Condition:   Depression
Interventions:   Behavioral: Family Cognitive Behavioral Prevention;   Behavioral: Written information
Sponsors:   Vanderbilt University;   San Diego State University
Recruiting


Bending Adolescent Depression Trajectories Through Personalized Prevention


Condition:   Depression
Interventions:   Behavioral: Interpersonal Psychotherapy- Adolescent Skills Training;   Behavioral: Coping with Stress
Sponsors:   Children's Hospital of Philadelphia;   National Institute of Mental Health (NIMH);   University of Denver;   Rutgers University;   University of Illinois at Urbana-Champaign
Active, not recruiting


Stepped Telemental Health Care Intervention for Depression


Condition:   Depression
Interventions:   Behavioral: Stepped Care;   Behavioral: Telephone Cognitive Behavior Therapy
Sponsor:   Northwestern University
Active, not recruiting


Using SMART Experimental Design to Personalize Treatment for Child Depression


Condition:   Depression
Interventions:   Behavioral: Cognitive Behavioral Therapy (CBT);   Behavioral: Caregiver-Child Treatment
Sponsor:   Massachusetts General Hospital
Active, not recruiting


Psychotherapy for Late Life Depression


Condition:   Depression
Interventions:   Behavioral: ENGAGE;   Behavioral: Standard of Care Psychotherapy
Sponsors:   Weill Medical College of Cornell University;   National Institute of Mental Health (NIMH)
Completed


Meditation for Depression


Condition:   Depression
Intervention:   Behavioral: Central Meditation and Imagery Therapy
Sponsor:   University of California, San Francisco
Completed


Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care for Depression


Condition:   Depression
Interventions:   Drug: Sertraline;   Drug: Placebo;   Drug: BupropionXL
Sponsor:   University of Texas Southwestern Medical Center
Completed


Systems of Support Study for Childhood Depression


Condition:   Depression
Interventions:   Behavioral: Family Focused Treatment (FFT);   Behavioral: Individual Treatment (IP)
Sponsors:   Boston University Charles River Campus;   University of California, Los Angeles;   National Institute of Mental Health (NIMH)
Completed


Organized Self-Management Support Services for Chronic Depression


Condition:   Depression
Intervention:   Behavioral: organized care program for chronic or recurrent depression
Sponsors:   Kaiser Permanente;   Swedish Medical Center
Completed


Aging Brain Changes, Executive Dysfunction and Depression


Condition:   Depression
Intervention:   Drug: Escitalopram
Sponsors:   Weill Medical College of Cornell University;   National Institute of Mental Health (NIMH);   Forest Laboratories
Completed


Self-guided Depression Treatment on Long-duration Spaceflights: A Continuation Study


Condition:   Depression
Intervention:   Behavioral: Computer-based Problem-Solving Treatment
Sponsors:   Beth Israel Deaconess Medical Center;   Dartmouth-Hitchcock Medical Center;   National Space Biomedical Research Institute
Completed


Treatment Response of Geriatric Depression


Condition:   Depression
Intervention:   Drug: Escitalopram
Sponsors:   Weill Medical College of Cornell University;   National Institute of Mental Health (NIMH);   Forest Laboratories
Recruiting

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