Allergies – General

About Allergies – General Clinical Trials (Click to Open)

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Allergy Clinical TrialsGeneral Purpose:

The purpose of allergy clinical trials will be to desensitize the immune systems of those fighting allergies to ideally reach tolerance of the allergen. Studies also intend to gain a better understanding of how allergens affect the immune system, which should facilitate enhanced treatment measures.

Moreover, food allergy trials often examine the role of white blood cells in disease. To prevent allergic reactions from food allergies, industries also run trials on large groups to determine the minimum eliciting dose of the allergic response.

What is a typical Allergy clinical trial like?

Trial participants will undergo screening that involves a physical examination and medical history. Blood samples will be collected to determine each individual’s sensitivity to the allergens being studied. Participants may also be given allergy skin tests. 

Typical Trial Protocol for Allergy Clinical Trials:

In studies targeting the desensitization of the immune response, participants may receive an extended period of sublingual immunotherapy. This immunotherapy is designed to develop an individual’s tolerance to the allergen being tested by placing a custom mixed solution under the participant’s tongue on a daily basis.

These trials may be quite lengthy, as prior research indicates that this form of immunotherapy takes 3 to 5 years for effective results. Developed tolerance of the allergen will be assessed at varying time points throughout the study.

In allergen eliciting dose trials, participants may receive varying levels of allergens in studies targeted at determining the minimum eliciting doses. Participants will first receive a baseline challenge, which may then be repeated with the addition of extrinsic factors (such as exercise) to determine the role of external factors on food allergies.

You should also note that as with any clinical trial, it is possible that you will be randomly selected for the placebo group. You would therefore undergo the same procedures as the treatment group without receiving the actual treatment being tested.

Suggested Search Terms:

Food Allergies, Peanut Hypersensitivity, Asthma and Allergies, Sublingual Immunotherapy for Allergies, Pediatric Allergies