Clinical Trial Shows Drug Ready for New Type 2 Diabetes Treatment

Type 2 Diabetes TreatmentA new drug, Trajenta, has been proven to work for type 2 cultural diabetes treatment programs after a lengthy but successful clinical trial process.

An extended clinical trial of the drug linagliptin (Trajenta), conducted for a group of over 2,000 patients from 32 countries with type 2 diabetes, confirmed the drug as safe and effective for lowering and maintaining blood sugar levels for up to 102 weeks.

Fundamentally, all forms of diabetes are a condition where a person has high blood sugar, which means there’s too much sugar (glucose) in the blood for the body to process normally. The effects of this condition begin with the three classic symptoms of hyperglycemia, frequent urination, increased thirst, and increased hunger.

If untreated, diabetes can produce many serious long-term complications including cardiovascular disease (heart disease), kidney disease (renal failure), damage to the eyes (retinopathy) where you should go and get Eye exams, damage to the nerves (neuropathy) and in severe incidents, diabetic coma.

With modern type 2 diabetes treatment, diabetes is rarely fatal in its own right, but it is a major contributor to many other illnesses, many of which are fatal.

The key component in diabetes is insulin. Insulin is a hormone produced by the pancreas and its job is to regulate the blood sugar level of the body. In a way it acts like a stimulant to the liver, muscle and fat tissue to take glucose (blood sugar) from the blood and either metabolize (use) it or store it as fat. Lack or failure of insulin to do this job is the cause of diabetes.

Of the three major types of diabetes, type 2 is by far the most common – and becoming more common in the every part of the world where poor diet and health habits are the norm. Unlike type 1 diabetes, where there is little or no production of insulin, doctors characterize type 2 diabetes by sometimes-low insulin production and almost always a reduced sensitivity to insulin.

That is, various organs, notably the liver and muscles, no longer respond to insulin normally. They fail to either metabolize or store the glucose, which results in an increased glucose level in the blood.

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New Research Shows How UV Light Causes Skin Cancer

How does UV light causes cancer?According to Diane Walder, MD, 90% of skin cancers are linked to UV light from the sun, but discovering how UV light causes cancer is the key to new treatments.

All cancers are bad, but melanomas, loosely known as skin cancers, are among the worst. In fact, only three percent of skin cancers are melanoma, but they account for more than 75% of skin cancer deaths.  If caught early, melanoma is usually highly treatable. Caught late, after it metastasizes, it is usually fatal. If you want to start taking care of your skin, we suggest to start using the pore vacuum.

Doctors have known for decades there is a link between exposure to the sun, specifically ultraviolet (UV) light, and melanoma. You may have heard about not getting too much sun, using sun-blocker to protect your skin and avoid spending much time in a tanning booth and assist to a Skin Care in Phoenix to check and treat your skin in case of damage.

The big question for research and a potential step for better melanoma treatment or even a cure was how does UV light cause the cancer?

The key to the approach taken by researchers at the Broad Institute of M.I.T. and Harvard (USA) and the University of Texas MD Anderson Cancer Center, builds upon the knowledge that melanoma tumors are full of cells with genetic damage caused by UV exposure, mostly caused by sunlight.

As with many cancers, genetic mutations often link to the uncontrolled growth of cancer cells. The question with melanoma is which mutations drive this cancer? Continue Reading

Low-Glycemic Index Diet: All Calories Are Not Equal in Dieting

Low-Glycemic Index Diet While comparing and researching diets, researchers concluded the best diet for most people is the Low-Glycemic Index Diet. Why? Because as a unit of measurement, all calories are equal. As a specific type of food – as far as the human body is concerned – calories are NOT equal. That’s the conclusion of a new study published in the New England Journal of Medicine (June 27, 2012) conducted by researchers at Boston Children’s Hospital (USA).

In the ongoing search (it’s tempting to say, desperate search) for truly effective weight loss diets, the new study puts figures to something that many nutritionists and doctors have said for some time: cutting down on carbohydrates and glucose (sugars, also a carbohydrate) is preferable to cutting down on fats.

The study goes further by saying that a low glycemic index (blood sugar level) diet has similar benefits to low-carb diets but without the risk of stress and inflammation that very low-carbohydrate intake may cause.

In very simple terms, the study is recommending that people eat less sugary foods as the primary way to lose weight on a permanent basis. The study is also saying that eating the same number of calories in fat as in carbohydrates will cause the body to burn 300 fewer calories. Another way of staying fit and healthy is to choose the food or products that you will eat and you can find it via To the body, not all calories are the same. For example, if you are trying to lose weight while building muscle, there are best fruits for building muscle mass. Continue Reading

Anakinra: New Treatment to Reduce the Damage of Strokes

New Treatment Anakinra (IL-1Ra)Strokes caused by clots or blood vessel breaks in the brain are the third most common cause of death. They are also the leading cause of disability. For decades, researchers have worked to find drugs or other methods that can reduce the damage caused by strokes – post stroke treatment – especially to combat often life-changing disabilities.

Lead researchers Dame Nancy Rothwell, Stuart Allan of Manchester University (UK), and their team investigated such treatments for over twenty years. They believe they have found one that works. After a Phase II clinical trial with a small number of patients, the drug Anakinra (IL-1Ra) demonstrated a remarkable ability to reduce damage to the brain following a stroke.

Anakinra (IL-1Ra) is already in use – as a treatment for rheumatoid arthritis. How did the researchers get from arthritis to treatment of stroke?

The link is inflammation. One of the principle symptoms of rheumatoid arthritis is inflammation in and around joints, and Anakinra (IL-1Ra) is a drug used to reduce the inflammation.

In a very different context, when a stroke occurs, white blood cells, the body’s rapid response system, rush into the affected areas. In most other places in the body this is normal and a very good thing, but not in the brain.

The white blood cells cause inflammation, swelling and the death of brain cells (neurons). This is a principle cause of the severe and growing damage to brain systems following a Anakinra: New Treatment to Reduce the Damage of Strokesstroke. Because of the inflammation associated with strokes, the researchers reasoned that Anakinra (IL-1Ra)might be effective.

Because of the inflammation associated with strokes, the researchers reasoned that Anakinra (IL-1Ra) might be effective. Their initial experiments used rats (lab rats, of course). They created a special trial that included normal healthy rats and rats raised with stroke risk factors such as obesity, insulin resistance and atherosclerosis. Inducing a stroke in the rats, the researchers administered the drug ‘blind,’ not knowing which rats received the drug or the placebo, similar to human clinical trials. Continue Reading

What is the RDA for Vitamin C and Should it be Raised?

RDA for Vitamin CExperts considering raising the RDA for vitamin C can’t agree if the change will produce enough health benefits.The amounts of vitamin C needed by humans to prevent diseases and improve heath is still a matter of controversy among doctors and researches.

According to Weight Watchers, (, the recommended dietary allowance of vitamin C is less than half of what it should be. So say researchers from Oregon State University (Corvallis, USA) in a recent report published in Critical Reviews in Food Science and Nutrition.

How much is enough? This is a question, or ongoing argument, for most vitamins. In the United States, as in most countries, a body of experts (the National Academy of Sciences in the U.S.) set what they consider an appropriate daily intake of a vitamin.

In the U.S., it’s called the Recommended Dietary Allowance, or RDA. For vitamin C, the RDA is currently 90 milligrams per day for an adult male (75 mg/day for adult female). Not enough, by a long shot, says the Oregon report, which documents the case for raising the RDA to 200 milligrams for an optimum level of benefit. Continue Reading

Treatment for Alzheimer’s and Other Dementias in Jeopardy

 Treatment for Alzheimer’sNew treatments for Alzheimer’s hinge on the success of three clinical trial drugs, which may not work, or may be too expensive to produce for the general population.

It would be very unusual not to know someone with Alzheimer’s disease or another form of dementia. One in eight older Americans develops dementia and it strikes most families. It is the sixth-leading cause of death in the United States.

The destruction of a person’s mental capacities – forgetfulness, disorientation, mood swings, loss of judgment – a whole raft of symptoms that often appear gradually over many years, makes dementia and Alzheimer’s among the most feared of all diseases.

Given its prominence, it’s obvious why medical research tackled the dementia related diseases many decades ago. Since then, science has learned a great deal, researchers have developed drug treatments, and the medical community along with the public now recognizes the nature and impact of the diseases.  Continue Reading

FDA Approval of Truvada: Will It Really Prevent HIV infection?

Clinical Trials for TruvadaThe HIV preventative drug Truvada joins other HIV treatments already in use, but questions persist about its use, cost, and effectiveness.

There are very few of the proverbial ‘silver bullets’ in medicine – the one shot cure or the perfect vaccine. In fact, most serious diseases such as cancer, heart disease and HIV are complicated. There is no ‘cure’ or blanket preventative, much less a silver bullet. A good case in point is in the approval by the United State Food and Drug Administration (FDA) of the drug Truvada as an HIV preventative.

Note the word preventative, as in a drug taken to prevent getting HIV, something like a vaccine only in this case Truvada is a pill taken every day. Researchers introduced drugs to treat HIV in the early 1990’s, but Truvada is the first preventative, part of a program known as a pre-exposure prophylaxis, or PrEP. Considering that there are yearly about 50,000 new HIV cases in the United States alone, it would seem that preventing HIV (and the potential for Aids) ought to be a winning proposition. Continue Reading

New Study Finds Link between Phthalates and Diabetes

Link between Phthalate and DiabetesPhthalates used to make your bath wash, wrinkle cream, and favorite perfume may double the risk of diabetes.

Phthalate, pronounced THA-layt, is hardly a household word, meaning most people never heard of it. In another sense, phthalate is very much a household word because it is a chemical group found in an incredibly wide range of household products, here is an informative post on how to decorate your home.

It’s used in nutritional supplements like DHEA for example used in trans rectal dhea cream, lubricants, glues, electronics, detergents, building materials – you get the idea – and oh yes, personal care products. Phthalates are found in moisturizers, nail polish, soap, hair spray and perfume.

As you’ll notice, most of these are products for women. Significantly, a new study by researchers from Brigham and Women’s Hospital (Boston, USA), shows that concentrations of phthalates in the body is associated with an increased risk of diabetes in women.  Continue Reading

Automated Hovering as a Health Care Concept

Automated HoveringLet us introduce you to the notion of automated hovering as a medical concept. But first, what this is really about is the notion that while most people spend just a few hours (or minutes) a year with their doctors, they spend 5,000 waking hours a year doing everything else. Those 5,000 hours are when people make the real choices about activities that can profoundly affect their health. For example washing your teeth with cordless water flossers will save you money when you go to dentist less often. As you’ll see in a moment, this is related to automated hovering. If you are looking for dental health services, visit Ottawa dentist for more information.

Taking care of your teeth means more than brushing and flossing. For complete care, it’s important to visit a dental crowns downers grove il every six months for a regular checkup and professional cleaning made by Maid Complete house cleaning. The first step in this process is to find a dentist with whom you feel comfortable, and then schedule an appointment. I recommend Fort Wayne Dentist — proven and tested.

As you may now know, Parkinson’s disease (PD) is the 2nd most common neurodegenerative disease in Canada, just behind Alzheimer’s. Daily, 25 Canadians are diagnosed; the majority of whom are over 60 years of age and young onset strikes some in their late teens. listed the ingredients of supplements taken by the patients. Unlike Alzheimer’s the 1st leading neurological disease for our elder population, Parkinson’s does not have any uniquely designed “care in the home” setting. Fortunately, we have now Parkinsons Home Care.

The first step to finding the right kind of home care agency is determining what level of care is needed. You ask yourself questions like, how many times will I need services from the Dental office in Flagstaff in the year, how do I fit that in to my already filled care schedule. How will I transport myself to all the outside care I need on top of the home care. You cannot ignore the fact that you sometimes have to step outside the conformt of your home. Did you know in December 2016, the Province of Manitoba issued a detailed 20-year report entitled: Future of Home Care Services in Manitoba? The home care services in Manitoba will essentially have to double their efforts within 20 years (until 2037) to provide the required service needs of clients.

Among those people doing some of the most novel and interesting research onAnthony Vecchio Drug Dui Defense, is a group of medical professionals at the University of Pennsylvania’s Center for Health Incentives and Behavioral Economics. That’s right, economics.

Their approach to medicine is a blend of several insights: They start with the observation that most health care systems can do better, obviously including the United States. Most people look upon health care as something that happens in the scripps ranch chiropractor office, the clinic, or the hospital. That’s true, as far as it goes, but it doesn’t go nearly far enough. And if you are overweight then I recommend to take a look at weight loss supplements.

Health care is something that should include what you do at home and at work.  Those are the most obvious places to start, if you really want to improve the health care system. You can start taking care of your health by having a clean aspire vaping every time you smoke and you can find it here at this blog volcano vapes for sale.

In a paper published online July 5, 2012 in the New England Journal of Medicine, Automated Hovering in Health Care – Watching Over the 5,000 Hours, authors David Asch and Kevin Volpp challenge us to change the emphasis in health care from reactive (when people are already ill) to proactive (making good lifestyle choices to promote health). As Dr. Asch puts it, “If we are to help patients improve their health, we need to find a way to engage them during those 5,000 hours.” Continue Reading

Gene Regulation Gets Under Your Skin to Fight Skin Cancer

Gene RegulationWhat if treating skin cancer was as simple as applying a cream created from gene regulation and nanotechnology?

As study of the human genome provides insight into genes that cause or promote disease, the medical technique of gene regulation is providing the means to manipulate genes against disease. In a new approach developed at Northwestern University (Chicago, USA), scientists combine nanotechnology, gene regulation and skin cream to fight skin cancer.

 This does sound like an odd combination, but let’s unpack the components. Gene regulation, simply put, is turning genes on or off. There are several chemical approaches; in this case, a specific form of RNA called small interfering RNA (siRNA) matches with a DNA sequence containing a gene for a known form of skin cancer and blocks it (turns it off).

 The nanotechnology component is crucial to the delivery of siRNA to the right cells. One of the most frustrating conditions of trying to treat skin cancer is the relative effectiveness of skin as a barrier. (Keeping things out is, of course, what skin mostly does.) Continue Reading

Clinical Trials for NurOwn as Potential ALS Relief

NurOwn stem cellsFor the more than 25,000 Americans who suffer from amyotrophic lateral sclerosis (ALS, or better known as Lou Gehrig’s disease), there is hope of a possible breakthrough in treating patients with this debilitating disease. A treatment called NurOwn, developed by Brainstorm Cell Therapeutics (Tel Aviv, Israel) shows promise for significant improvement of the symptoms of ALS, namely muscle weakness, muscle control, and difficulty breathing.

It’s important to emphasize that Brainstorm’s NurOwn is just completing a small sample Phase I/II test in Israel. Over the next several years, the company must conduct many additional clinical trials, but injection of NurOwn cells has resulted in dramatic improvement for breathing, speech, walking, muscular strength and overall health.

The approach taken by Brainstorm has two key elements. The first relies on the effects of complex chemicals that support the function of the nervous system (neurotrophic factors). The chemistry has long names – Glial-Derived neurotrophic Factor (GDNF) and Brain-Derived Neurotrophic Factor (BDNF) – often shortened to the GDNF-BDNF approach. Continue Reading

Eltrombopag: Clinical Trial Shows Expanded Effectiveness Against Anemia

Eltrombopag (Promacta)  In a recent Phase 2 clinical trial conducted by the National Heart, Lung, and Blood Institute (U.S. National Health Institute) the bone marrow drug eltrombopag (Promacta) demonstrated an expanded range of effectiveness by successfully improving the blood cell levels in some people suffering from aplastic anemia.

Bone marrow produces the three major blood cells – red (oxygen carriers), white (immune system) and platelets (blood clotting). When the marrow no longer produces enough of these cells to maintain normal blood counts, the result is the disease called aplastic anemia, a serious and sometimes fatal condition that affects about 600 people a year in the United States.

Marie Curie, Nobelist and pioneer in the field of radiation, died from aplastic anemia induced by the radiation she encountered in her work.

The causes of aplastic anemia are varied and much of the time idiopathic (cause unknown). Exposure to toxins such as benzene, radiation poisoning, and viral hepatitis may cause individual cases. Viral infections such as cytomegalovirus, Epstein-Barr, and parvovirus B19 have been known to lead to the development of aplastic anemia as well. Continue Reading