Type 1 Diabetes

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Diabetes (Type 1) Clinical Trials

General purpose: Research related to type 1 diabetes may investigate new methods for diagnosing diabetes, ways to refine the diagnostic accuracy of existing test methods, improved treatment options (such as different insulin delivery methods or newly developed oral medications designed to control blood glucose levels), and behavioral / lifestyle factors that can aid in the management of type 1 diabetes.

In addition, research may also look at possible genetic factors that might make a person more likely to develop type 1 diabetes.

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Diabetes (Type 1) Clinical Trials

Type 1 Diabetes Clinical Trials

What do typical clinical trials for Type 1 Diabetes involve?

Clinical trials will vary widely in the information they collect, as well as the tests and procedures they use. All of these factors will depend on individual study designs, which will differ greatly between trials.

However, below is a list of common procedures and data that are frequently collected during a trial for Type 1 Diabetes:

  • Fasting blood glucose levels.
  • Random blood glucose levels.
  • Oral glucose tolerance tests, which involves drinking a sweet drink with a known amount of glucose and then having blood drawn at regular intervals over a specified period of time (usually several hours).
  • Hemoglobin A1c test, which measures an individual’s average blood glucose level over a two to three month period.
  • Urine sample or blood sample to measure ketone levels (ketones are produced when the body burns fat for energy rather than glucose).
  • Monitoring of body weight.
  • Monitoring of cholesterol and triglyceride levels, blood pressure, kidney function, and nerve function.
  • Visual inspection of the skin and bones on feet and legs.
  • Food intake monitoring using food diaries or computer-based tracking systems.

Examples of Type 1 Diabetes-related research topics:

  • Immune therapy for the prevention and treatment of diabetes.
  • New therapies designed to improve glucose control.
  • New therapies designed to treat the complications associated with diabetes, such as nerve pain, vision loss, and kidney damage.
  • Research designed to develop vaccines against the factors that trigger the immune system to attack the pancreas.
  • Development of new therapies to stop or reverse the immune system’s attack on the pancreas, thereby removing the need for insulin therapy.

Suggested search terms for best results:  “obesity and diabetes,” “children and diabetes,” “insulin and diabetes,” “diabetes prevention,” “diabetes treatment.”



Impact of the Continuous Measurement of Blood Glucose on Insulin Pump on Child Quality of Life With Type 1 Diabetes


Condition:   Type1diabetes
Interventions:   Behavioral: Peds QL questionnaire and diabetes modulate;   Behavioral: WHO-5 questionnaire;   Behavioral: Felt questionnaire
Sponsor:   Groupe Hospitalier de la Region de Mulhouse et Sud Alsace
Active, not recruiting


Group Education Curriculum for Older Teens With Type 1 Diabetes


Condition:   Type 1 Diabetes Mellitus
Intervention:   Behavioral: Intervention
Sponsor:   Boston Children’s Hospital
Recruiting


Comparison of the Use of Energy Substrates and Hormonal Regulation of Blood Sugar During Exercise of Increasing Intensity Between Children With Type 1 Diabetes and Non-diabetic Control Children.


Condition:   Type 1 Diabetes
Intervention:   Procedure: controlled physical activity
Sponsor:   University Hospital, Clermont-Ferrand
Not yet recruiting


Vitamin D and Residual Beta-Cell Function in Type 1 Diabetes


Condition:   Type 1 Diabetes
Interventions:   Drug: Ergocalciferol;   Other: Placebo
Sponsor:   University of Massachusetts, Worcester
Recruiting


Use of Continuous Glucose Monitoring System With Intensive Feedback in Adolescents With Poorly Controlled Type 1 Diabetes


Condition:   Type 1 Diabetes
Interventions:   Device: CGMS Device;   Other: No Device
Sponsor:   New York University School of Medicine
Enrolling by invitation


Evaluation of the Dreamed Advisor Pro for Automated Insulin Pump Setting Adjustments in Children and Adolescents With Type 1 Diabetes- The Advice4U Pro Study


Condition:   Type1 Diabetes Mellitus
Interventions:   Device: DreaMed Advisor Pro;   Other: Medical guided recommendation
Sponsors:   Rabin Medical Center;   DreaMed;   The Leona M. and Harry B. Helmsley Charitable Trust
Recruiting


Incretin-based Therapy in Early Diagnosed Type 1 Diabetes


Condition:   Type 1 Diabetes
Interventions:   Drug: Victoza® (liraglutide);   Drug: Placebo
Sponsors:   University of Oulu;   Oulu University Hospital;   Tampere University Hospital;   Turku University Hospital;   Skane University Hospital
Enrolling by invitation


A Study of ASP1941 in Combination With Insulin in Patients With Type 1 Diabetes Mellitus


Condition:   Type 1 Diabetes Mellitus
Interventions:   Drug: ipragliflozin;   Drug: Placebo;   Other: Insulin Therapy
Sponsor:   Astellas Pharma Inc
Active, not recruiting


Incretin-based Therapy in Late Preclinical Type 1 Diabetes


Condition:   Type 1 Diabetes
Interventions:   Drug: Victoza®;   Drug: Placebo
Sponsors:   University of Oulu;   Oulu University Hospital;   Tampere University Hospital;   Turku University Hospital;   Skane University Hospital
Enrolling by invitation


Health Economic Analysis of Islet Cell Transplantation for the Stabilization of the Severe Forms of Type 1 Diabetes


Condition:   Type 1 Diabetes
Interventions:   Procedure: Islet graft;   Drug: best medical care
Sponsor:   University Hospital, Grenoble
Recruiting


Closed-loop Control of Glucose Levels (Artificial Pancreas) for 12 Days in Adults With Type 1 Diabetes


Condition:   Type 1 Diabetes
Interventions:   Other: 12-day intervention with sensor-augmented pump therapy;   Other: 12-day intervention with single-hormone closed-loop strategy;   Device: Insulin pump;   Device: Continuous glucose monitoring system;   Drug: Insulin
Sponsor:   Institut de Recherches Cliniques de Montreal
Not yet recruiting


Gene-virus Interactions Implicated in Type 1 Diabetes


Condition:   Type 1 Diabetes
Intervention:   Genetic: Enterovirus vaccination
Sponsor:   Hospices Civils de Lyon
Not yet recruiting


Modulation of STAT3 Signaling With Siltuximab in Type 1 Diabetes


Condition:   Type 1 Diabetes
Intervention:   Drug: Siltuximab
Sponsors:   Carla Greembaum, MD;   Janssen Research & Development, LLC
Completed


Incretin-based Therapy in Preclinical Type 1 Diabetes in Adults


Condition:   Type 1 Diabetes
Interventions:   Drug: Victoza®;   Drug: Placebo
Sponsors:   University of Oulu;   Oulu University Hospital;   Tampere University Hospital;   Turku University Hospital
Enrolling by invitation


The Safety and Efficacy of Dapagliflozin Therapy in Combination With Insulin in Japanese Subjects With Type 1 Diabetes Mellitus (T1DM)


Condition:   Type 1 Diabetes Mellitus
Interventions:   Drug: Dapagliflozin 5 mg;   Drug: Dapagliflozin 10mg
Sponsor:   AstraZeneca
Completed


Pancreas Volume in Preclinical Type 1 Diabetes


Condition:   Type 1 Diabetes
Intervention:   Procedure: MRI, US, and blood samples
Sponsors:   University of Florida;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting


An Evaluation of Novel Glucose Sensing Technology on Hypoglycaemia in Type 1 Diabetes (IMPACT)


Condition:   Type 1 Diabetes Mellitus
Interventions:   Device: Sensor Based Glucose Monitoring System;   Device: Standard Blood Glucose Monitoring
Sponsor:   Abbott Diabetes Care
Completed


Tauroursodeoxycholic Acid (TUDCA) in New-Onset Type 1 Diabetes


Condition:   Type 1 Diabetes
Interventions:   Drug: Tauroursodeoxycholic Acid (TUDCA);   Drug: Sugar Pill (placebo)
Sponsors:   Robin Goland, MD;   Juvenile Diabetes Research Foundation
Recruiting


Reducing Distress And Improving Glycemic Control In Adults With Type 1 Diabetes


Condition:   Type 1 Diabetes Mellitus
Interventions:   Behavioral: 'KnowIt';   Behavioral: 'OnTrack'
Sponsors:   University of California, San Francisco;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Active, not recruiting


The Effects of Mediterranean Diet on Remission, Lipid Profile, Weight and Body Composition in Children and Adolescents With Newly Diagnosed Type 1 Diabetes


Condition:   Type 1 Diabetes
Interventions:   Other: Interventional arm-Mediterranean diet;   Other: Control Arm- regular nutritional instructions in accordance with the accepted nutritional guidelines
Sponsor:   Rabin Medical Center
Terminated


52 Week Trial of Liraglutide in Type 1 Diabetes


Condition:   Type 1 Diabetes
Interventions:   Drug: Liraglutide;   Drug: Placebos
Sponsors:   CHU de Quebec-Universite Laval;   Novo Nordisk A/S
Completed


Open-label Investigation of the Safety and Effectiveness of DIABECELL® in Patients With Type 1 Diabetes Mellitus


Condition:   Type 1 Diabetes
Intervention:   Device: DIABECELL (R)
Sponsor:   Diatranz Otsuka Limited
Completed


Liraglutide in Type 1 Diabetes


Condition:   Type 1 Diabetes
Interventions:   Drug: Liraglutide 1.8mg;   Drug: Placebo
Sponsors:   University at Buffalo;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting


Imaging of Type 1 Diabetes Progression


Condition:   Type 1 Diabetes
Intervention:   Drug: ferumoxytol
Sponsors:   Jason Gaglia;   National Institute of Allergy and Infectious Diseases (NIAID);   Harvard Medical School
Active, not recruiting


Diabetes Care Management Compared to Standard Diabetes Care in Adolescents and Young Adults With Type 1 Diabetes


Condition:   Type 1 Diabetes
Intervention:   Other: Transition Coordinator
Sponsors:   University of Western Ontario, Canada;   Juvenile Diabetes Research Foundation
Active, not recruiting

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