Food Allergies

Food Allergy Clinical TrialsFood Allergy Clinical Trials

General Purpose: Allergic symptoms arise when the immune system becomes over-sensitized (i.e., over-reactive) to a particular allergen or irritant. In the case of food allergies, an abnormal response of the body’s immune system to foods such as peanuts, shellfish, and milk can result in an allergic reaction.

Allergic reactions can vary from skin irritation to more serious complications including gastrointestinal disorders and anaphylaxis, which could also result in anaphylactic shock. The purpose of food allergy trials often examines the role of white blood cells in disease in order to determine how the immune system responds to a particular food allergy.

To prevent allergic reactions from food allergies, industries also run trials on large groups to determine the minimum eliciting dose of the allergic response.

Food Allergy Clinical Trials Continued … (Click to Open)

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What are Typical Food Allergy Clinical Trials Like?

Trial participants will undergo screening that involves a physical examination and medical history. In addition, blood samples will be collected to determine each individual’s sensitivity to the allergens being studied.

Additional tests may be performed to determine the participant’s level of sensitivity to particular foods, as well as stool sample testing for those participants who have eosinophil-associated gastrointestinal disorders.

Typical Trial Protocol for Food Allergy Clinical Trials:

Some studies seek to decrease the reaction of the immune system by gradually exposing individuals to small amounts of allergens over an extended period of time, in an effort to increase an individual’s tolerance.

This is known as immunotherapy. Immunotherapy trials can be lengthy, and may span over the course of several years. During these trials, individual participants’ tolerance to the allergen or allergens being studied will be assessed via blood tests at specified time points.

Other allergy-related trials may seek to determine the amount of exposure to a particular allergen that is required in order to elicit an allergic response. Trials such as this may also randomly assign some participants to receive a placebo, so that the results between the allergen and placebo group can be compared.

As a result, those in the placebo group would receive the same protocol procedures that the allergen group received, however they would not be exposed to the actual allergen being studied.

Suggested Search Terms

Food Allergies, Food Hypersensitivity, Peanut Hypersensitivity, Pediatric Diseases, Gastrointestinal Diseases.

Current Search Term: “Food Allergy”



Anxiety About Casual Exposure to Food Allergens


Condition:   Food Allergy
Interventions:   Behavioral: Behavioral intervention group;   Behavioral: Education
Sponsor:   Icahn School of Medicine at Mount Sinai
Recruiting


Staff Management About Food Allergy Into ResTaurants


Condition:   Food Allergy
Intervention:  
Sponsor:   Centre Hospitalier Régional Metz-Thionville
Completed


Effect of Mediterranean Diet During Pregnancy on Gut Microbiota and on the Epigenetics


Condition:   Food Allergy
Intervention:   Behavioral: mediterranean diet
Sponsor:   Federico II University
Recruiting


Safer Food Allergy Management for Adolescents


Conditions:   Food Allergy;   Adherence, Medication
Interventions:   Behavioral: Text Message Only;   Behavioral: Text message + Incentive 1;   Behavioral: Text message + Incentive 2
Sponsors:   University of Pennsylvania;   Children's Hospital of Philadelphia
Not yet recruiting


The Basophil Activation Test as a Diagnostic Tool in Pediatric Food Allergy


Condition:   FOOD ALLERGY
Intervention:   Diagnostic Test: The basophil activation test (BAT)
Sponsor:   Assistance Publique Hopitaux De Marseille
Recruiting


Longitudinal Follow-up Study for Food Allergies


Condition:   Food Allergy
Intervention:   Other: Immunotherapy
Sponsor:   Stanford University
Enrolling by invitation


Multi OIT to Test Immune Markers After Minimum Maintenance Dose


Condition:   Food Allergy
Interventions:   Drug: Omalizumab;   Drug: Food Flour Allergens
Sponsors:   Kari Christine Nadeau;   University of California, Los Angeles
Recruiting


Improvement of Foodallergy Diagnostic in Gastrointestinal Tract


Condition:   Food Allergy
Intervention:   Diagnostic Test: Cytobrush
Sponsor:   University of Erlangen-Nürnberg Medical School
Recruiting


Basophile Activation Testing (BAT) in Hazelnut Allergy (Hazelnut BAT Study)


Condition:   Food Allergy
Interventions:   Diagnostic Test: Food challenge;   Diagnostic Test: skin testing;   Diagnostic Test: blood sampling
Sponsors:   University of Zurich;   ADR-AC Laboratory, Berne
Recruiting


Registry of Food Allergy Oral Immunotherapy Treatment


Condition:   Food Allergy
Intervention:  
Sponsor:   Food Allergy Support Team
Not yet recruiting


Association Between Asthma and Food Allergy


Conditions:   Food Allergy Suspected;   Food Allergy Proved
Intervention:   Other: Pulmonary function test
Sponsor:   University Hospital, Montpellier
Recruiting


Study Using Xolair in Rush Multi Oral Immunotherapy in Multi Food Allergic Patients


Condition:   Food Allergy
Interventions:   Drug: Xolair;   Drug: Placebo
Sponsors:   Stanford University;   National Institute of Allergy and Infectious Diseases (NIAID)
Completed


Oral Immunotherapy in Food Allergy in Finland


Conditions:   Food Hypersensitivity;   Immune System Diseases;   Anaphylaxis
Intervention:   Dietary Supplement: Milk
Sponsor:   Helsinki University Central Hospital
Enrolling by invitation


Multi Immunotherapy to Test Tolerance and Xolair


Condition:   Food Allergy
Interventions:   Drug: Omalizumab;   Drug: Food Flour Buildup
Sponsors:   Kari Christine Nadeau;   Icahn School of Medicine at Mount Sinai;   Children's Hospital of Philadelphia;   Ann & Robert H Lurie Children's Hospital of Chicago;   Children's Hospital Medical Center, Cincinnati;   Children's Hospital Los Angeles;   University of Washington
Completed


Natural History and Genetics of Food Allergy and Related Conditions


Conditions:   Food Allergy;   Loeys-Dietz Syndrome
Intervention:  
Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting


Prevention and Management of Food Allergies


Conditions:   Empathy;   Food Allergy
Intervention:   Other: Photograph
Sponsor:   University of Pennsylvania
Completed


Molecular Analysis of IgE Antibodies in Walnut Allergic Patients


Condition:   Food Allergy
Intervention:   Other: walnut allergy provocation
Sponsors:   University of Zurich;   Paul Ehrlich Institute Langen;   Hospital Clinic of Barcelona;   St. Marien Hospital Bonn;   Thermo Fisher Scientific
Completed


Blood Samples for the Study of Peanut, Tree Nut and Other Food Allergies


Conditions:   Peanut Allergies;   Tree Nut Allergies;   Other Food Allergies
Intervention:  
Sponsors:   University of Colorado, Denver;   National Institutes of Health (NIH)
Recruiting


Intranasal Diagnostics in Food Allergy: a Feasibility Study


Condition:   Food Allergy
Interventions:   Other: Intranasal challenge with active substance (food protein);   Other: Intranasal challenge with placebo
Sponsors:   Imperial College London;   National Institute for Health Research, United Kingdom
Enrolling by invitation


Can Vitamin D Supplementation in Infants Prevent Food Allergy in the First Year of Life? The VITALITY Trial


Condition:   Food Allergy
Interventions:   Drug: Vitamin D;   Drug: placebo
Sponsor:   Murdoch Childrens Research Institute
Recruiting


Mixed Tree Nut Food Challenges


Condition:   Food Allergy
Intervention:  
Sponsor:   Arkansas Children's Hospital Research Institute
Enrolling by invitation


Baked Egg or Egg Oral Immunotherapy for Children With Egg Allergy


Condition:   Food Allergy
Interventions:   Drug: Egg Oral Immunotherapy;   Drug: Baked Egg
Sponsors:   Hugh A Sampson, MD;   National Institute of Allergy and Infectious Diseases (NIAID);   Consortium of Food Allergy Research
Active, not recruiting


Molecular Basis of Food Allergy


Conditions:   Food Allergy;   Eosinophilic Esophagitis
Intervention:  
Sponsors:   Children's Hospital of Philadelphia;   University of Pennsylvania;   National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting


The Effect of Per Oral Immunotherapy in Severe IgE Mediated Egg, Milk, and Nut Allergy in Adults


Condition:   Food Allergy
Intervention:   Dietary Supplement: Dietary supplement
Sponsor:   Helsinki University Central Hospital
Active, not recruiting


Effects of Montelukast in Asthmatic Children With and Without Food Allergy


Conditions:   Bronchial Asthma;   Food Allergy;   Children
Intervention:   Drug: Montelukast
Sponsors:   Hacettepe University;   Merck Sharp & Dohme Corp.
Completed

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