Cocaine Dependence



Cocaine Use Disorder and Cortical Dopamine


Condition:   Cocaine Dependence
Interventions:   Drug: d-amphetamine;   Radiation: [C-11]FLB 457
Sponsors:   University of Pittsburgh;   National Institute on Drug Abuse (NIDA)
Recruiting


Rebalancing the Serotonergic System in Cocaine Dependence


Condition:   Cocaine Dependence
Interventions:   Drug: Lorcaserin;   Drug: Placebo Oral Tablet
Sponsor:   Mclean Hospital
Not yet recruiting


Functional Magnetic Resonance Imaging of N-acetylcysteine in Cocaine Dependence


Condition:   Cocaine Dependence
Interventions:   Dietary Supplement: N-acetylcysteine;   Other: Placebo
Sponsor:   Yale University
Recruiting


Understanding Dopamine Mechanisms in Cocaine Addiction Using AMPT and Methylphenidate With [11C]RAC/[11C]PHNO PET


Condition:   Cocaine Dependence
Interventions:   Drug: Methylphenidate;   Drug: Alpha Methyl Para Tyrosine (AMPT);   Other: [11C]PHNO;   Other: [11C]raclopride
Sponsor:   Yale University
Recruiting


Bupropion-Enhanced Contingency Management (CM) for Cocaine Dependence


Conditions:   Substance Abuse;   Cocaine Dependence
Interventions:   Drug: Bupropion XL;   Drug: placebo
Sponsor:   Johns Hopkins University
Recruiting


Brain Function and Structure in Cocaine Dependence


Condition:   Cocaine Dependence
Interventions:   Drug: Citalopram;   Drug: Placebo
Sponsors:   Virginia Commonwealth University;   The University of Texas Health Science Center, Houston;   National Institute on Drug Abuse (NIDA)
Completed


A Sequenced Behavioral and Medication Intervention for Cocaine Dependence


Condition:   Cocaine Dependence
Interventions:   Behavioral: Computer-assisted behavior therapy;   Drug: Mixed amphetamine salts;   Drug: Computer-assisted CBT plus placebo
Sponsors:   New York State Psychiatric Institute;   National Institute on Drug Abuse (NIDA)
Recruiting


Multicenter Trial of Combined Pharmacotherapy to Treat Cocaine Dependence


Condition:   Cocaine Dependence
Interventions:   Drug: Adderall-ER;   Drug: Topiramate;   Other: Placebo
Sponsors:   New York State Psychiatric Institute;   National Institute on Drug Abuse (NIDA)
Completed


A Multi-Center Trial of Nepicastat for Cocaine Dependence


Condition:   Cocaine Dependence
Interventions:   Drug: Nepicastat;   Drug: Placebo
Sponsor:   National Institute on Drug Abuse (NIDA)
Completed


The Effect of Brief Potent Glutamatergic Modulation on Cocaine Dependence


Condition:   Cocaine Dependence
Interventions:   Drug: Ketamine;   Drug: Midazolam
Sponsors:   New York State Psychiatric Institute;   National Institute on Drug Abuse (NIDA)
Terminated


Citalopram for Cocaine Dependence


Condition:   Cocaine Dependence
Interventions:   Drug: Citalopram;   Drug: Placebo
Sponsors:   Joy Schmitz;   National Institute on Drug Abuse (NIDA)
Completed


Imaging the Neurobiology of Behavioral and Medication Treatment for Cocaine Dependence


Condition:   Cocaine Dependence
Interventions:   Drug: levodopa carbidopa and entacapone (LCE);   Drug: Placebo
Sponsor:   New York State Psychiatric Institute
Completed


Cognitive Remediation for Cocaine Dependence


Condition:   Cocaine Dependence
Interventions:   Drug: levodopa/carbidopa;   Drug: Ropinirole;   Drug: Placebo
Sponsor:   The University of Texas Health Science Center, Houston
Completed


Psychopharmacology for Cocaine Dependence - Buspirone


Condition:   Cocaine Dependence
Interventions:   Drug: Buspirone;   Drug: Placebo for Buspirone;   Drug: Methylphenidate;   Drug: Placebo for Methylphenidate
Sponsor:   The University of Texas Health Science Center, Houston
Completed


Effectiveness of Enhanced Treatments for Drug Dependence


Condition:   Cocaine Dependence
Intervention:   Behavioral: Telephone Monitoring and Counseling - Enhanced
Sponsor:   University of Pennsylvania
Completed


Pharmacogenetics of Doxazosin for Cocaine Dependence


Condition:   Cocaine Dependence
Interventions:   Drug: Doxazosin;   Drug: Placebo
Sponsors:   Baylor College of Medicine;   National Institute on Drug Abuse (NIDA)
Completed


Reward Processing in Cocaine Addiction


Conditions:   Drug Abuse;   Cocaine Dependence
Intervention:  
Sponsors:   National Institute on Drug Abuse (NIDA);   National Institute of Mental Health (NIMH)
Completed


Multisite Controlled Trial of Cocaine Vaccine


Condition:   Cocaine Dependence
Interventions:   Drug: TA-CD Vaccination;   Other: Placebo Injection
Sponsors:   Baylor College of Medicine;   National Institute on Drug Abuse (NIDA);   US Department of Veterans Affairs Cooperative Studies Program;   VA Maryland Health Care System;   Columbia University;   VA New York Harbor Healthcare System;   University of Pennsylvania;   Johns Hopkins University;   University of Cincinnati;   Celtic Pharma Development Services
Completed


Brain Glutamate Receptors and Cocaine Dependence


Conditions:   Drug Abuse;   Cocaine Dependence
Intervention:  
Sponsor:   National Institute on Drug Abuse (NIDA)
Terminated


Pharmacotherapy & CM for Opioid and Cocaine Dependence


Condition:   Cocaine Dependence
Interventions:   Drug: Modafinil;   Drug: Sugar Pill;   Behavioral: Contingency Management;   Drug: Methadone;   Behavioral: cognitive behavioral treatment;   Behavioral: Voucher Control
Sponsors:   Yale University;   National Institute on Drug Abuse (NIDA)
Completed


Caffeine and Cocaine


Condition:   Cocaine Dependence
Interventions:   Drug: Caffeine 150 MG;   Drug: Placebo;   Drug: Amphetamine;   Drug: Caffeine 300 MG
Sponsors:   Virginia Commonwealth University;   National Institute on Drug Abuse (NIDA);   The University of Texas Health Science Center, Houston
Completed


Carbidopa/Levodopa Combined With Behavioral Therapy for the Treatment of Cocaine Dependence


Condition:   Cocaine Dependence
Interventions:   Drug: levodopa;   Drug: Placebo
Sponsors:   The University of Texas Health Science Center, Houston;   National Institute on Drug Abuse (NIDA)
Completed


Clinical Trial of Topiramate for Cocaine Addiction


Condition:   Cocaine Dependence
Interventions:   Drug: topiramate;   Behavioral: Contingency Reinforcement;   Drug: placebo + NonCR
Sponsors:   Johns Hopkins University;   National Institute on Drug Abuse (NIDA)
Completed


A Placebo-Controlled Study of Mixed Amphetamine Salts and Topiramate for the Treatment of Cocaine Dependence


Condition:   Cocaine Dependence
Interventions:   Drug: Adderall-XR and Topiramate;   Drug: Placebo
Sponsors:   New York State Psychiatric Institute;   National Institute on Drug Abuse (NIDA)
Completed


Study of the Effects of Risperdal Consta on Brain Reward Circuitry Function, Craving and Cocaine Use in Active Cocaine Dependence


Condition:   Cocaine Dependence
Interventions:   Drug: Risperidone;   Drug: Placebo
Sponsors:   Massachusetts General Hospital;   Janssen, LP
Completed

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