Alcoholism



Ibogaine in the Treatment of Alcoholism: a Randomized, Double-blind, Placebo-controlled, Escalating-dose, Phase 2 Trial


Condition:   Alcoholism
Intervention:   Drug: Ibogaine Hydrochloride
Sponsors:   University of Sao Paulo;   Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.;   Conselho Nacional de Desenvolvimento Científico e Tecnológico
Not yet recruiting


Ketogenic Diet (KD) in Alcoholism


Condition:   Alcoholism
Interventions:   Dietary Supplement: Ketogenic Diet (KD);   Dietary Supplement: Standard American (SA) Meals and Shakes
Sponsor:   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Recruiting


Individualized Assessment and Treatment for Alcoholism II


Condition:   Alcoholism
Interventions:   Behavioral: Individualized Assess & Treatment (IATP);   Behavioral: Packaged Cognitive-Behavioral (PCBT);   Behavioral: Case Management (CaseM)
Sponsors:   UConn Health;   Ronald M. Kadden;   Howard Tennen
Recruiting


Clinical Study of TripleA for Treatment of Alcohol Addiction in Outpatient Care


Condition:   Alcoholism
Intervention:   Device: TripleA
Sponsors:   Kontigo Care AB;   Uppsala University
Active, not recruiting


New Therapeutic Strategies for Inhibitory Control in Alcoholism


Condition:   Alcoholism
Interventions:   Behavioral: Retrieval-Extinction Learning;   Other: rTMS;   Other: SAM
Sponsors:   Hospital Universitario 12 de Octubre;   Ministerio de Sanidad, Servicios Sociales e Igualdad
Recruiting


Testing Doxazosin to Treat Stress Mechanisms in Alcoholism


Condition:   Alcoholism
Interventions:   Drug: Doxazosin;   Other: Placebo
Sponsors:   University of Wisconsin, Madison;   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Recruiting


Repurposing alpha1 Noradrenergic Antagonists for Alcoholism Treatment


Condition:   Alcoholism
Interventions:   Drug: Prazosin;   Drug: Placebo
Sponsors:   University of Wisconsin, Madison;   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Recruiting


Interdisciplinary Study of A Novel Anticonvulsant in Alcoholism


Condition:   Alcohol Dependence
Interventions:   Drug: Zonisamide;   Behavioral: Take Control;   Drug: Placebo (for Zonisamide)
Sponsors:   Boston University Charles River Campus;   Mclean Hospital;   University of Houston
Recruiting


A Novel Compound for Alcoholism Treatment: A Translational Strategy


Condition:   Alcoholism
Interventions:   Drug: PF-05190457;   Behavioral: MI-VF;   Other: Placebo;   Other: Counseling
Sponsor:   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Recruiting


Validation of a Test System for Development of Medications for Alcoholism


Condition:   Alcoholism
Interventions:   Drug: Naltrexone;   Drug: Placebo
Sponsor:   Technische Universität Dresden
Completed


Brain Inflammation and Function in Alcoholism


Condition:   Alcoholism
Interventions:   Device: MRI;   Drug: C-11PBR28;   Drug: F-18FDG
Sponsor:   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Recruiting


Medication Development in Alcoholism: Investigating PPAR Agonists


Condition:   Alcoholism
Interventions:   Drug: Sugar Pill;   Drug: TRICOR (fenofibrate)
Sponsors:   The Scripps Research Institute;   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Completed


Rapid Determination Of The Clinical Utility Of Perampanel For The Treatment Of Alcohol Dependence


Condition:   Alcoholism
Interventions:   Drug: Perampanel;   Drug: Placebo
Sponsor:   Yale University
Suspended


Efficacy and Safety of High Dose Baclofen for Alcohol Dependence


Condition:   Alcoholism
Interventions:   Drug: Baclofen;   Drug: Placebo
Sponsors:   University of North Carolina, Chapel Hill;   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Active, not recruiting


Characterization of [11C]Flumazenil to Image GABA Transmission in Healthy Adult Subjects and Subjects With Alcohol Dependence


Condition:   Alcoholism
Interventions:   Radiation: [11C]flumazenil;   Drug: Tiagabine
Sponsor:   Rajesh Narendran
Completed


Deep Brain Stimulation for Refractory Alcoholism


Condition:   Alcoholism
Intervention:   Procedure: Implantation of Deep Brain Stimulation
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Withdrawn


N-acetylcysteine Plus Naltrexone for the Treatment of Alcohol Dependence


Condition:   Alcoholism
Interventions:   Drug: N-acetylcysteine + high-dose naltrexone (150 mg);   Drug: High-dose naltrexone (150 mg) alone;   Drug: Low-dose naltrexone (50 mg) alone
Sponsor:   VA Office of Research and Development
Completed


Imaging Cannabinoid CB1 Receptors in Alcohol Dependence


Condition:   Alcoholism
Intervention:  
Sponsor:   National Institute of Mental Health (NIMH)
Completed


GABRA2 and the Pharmacokinetics of Risk for Alcoholism (GPRA)


Condition:   Alcoholism
Interventions:   Drug: Alcohol;   Drug: Placebo
Sponsors:   Indiana University;   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Active, not recruiting


Medication Development in Alcoholism: Acamprosate Versus Naltrexone


Condition:   Alcoholism
Interventions:   Drug: Acamprosate;   Drug: Naltrexone;   Drug: Placebo
Sponsors:   The Scripps Research Institute;   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Completed


Cannabinoid Receptor Function & Alcoholism


Condition:   Alcoholism
Interventions:   Drug: THC;   Drug: Placebo
Sponsors:   Yale University;   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Active, not recruiting


Intravenous Alcohol Administration Using BrAc Method in Healthy Subjects With and Without a Family History of Alcoholism


Condition:   Alcoholism
Intervention:   Drug: Ethanol High Dose, Ethanol Low Dose, and Placebo
Sponsors:   Yale University;   VA Connecticut Healthcare System;   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Completed


GABA Mechanisms Underlying the Vulnerability to Alcohol Dependence


Condition:   Alcoholism
Interventions:   Drug: Thiopental;   Drug: Placebo
Sponsors:   Yale University;   VA Connecticut Healthcare System
Completed


Alcoholism: Emotion and Thinking


Condition:   Alcoholism
Interventions:   Procedure: Magnetic Resonance Imaging (MRI);   Behavioral: Interviews, cognitive tests, and emotional measurements
Sponsors:   Boston University;   National Institute on Alcohol Abuse and Alcoholism (NIAAA);   VA Office of Research and Development
Recruiting


Naltrexone Maintenance Treatment of Alcoholism


Condition:   Alcoholism
Interventions:   Drug: Naltrexone Tablet;   Drug: Matched Placebo Tablet
Sponsors:   The Scripps Research Institute;   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Completed

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