Acne

About Acne Clinical Trials (Click to Open)

Join Clinical Trials for Acne

Acne

General Purpose:

Acne is a condition that is characterized by the formation of pimples, which result when tiny pores on the surface of the skin become clogged by dirt, bacteria, and dead skin cells. The clog creates a “plug” at the top of the pore. If the plug is white it is referred to as a whitehead, whereas dark plugs are called blackheads.

Sometimes, these plugs can break open, which leads to swelling and the presence of additional red bumps. Occasionally, acne can develop in deeper layers of the skin and result in hard, painful areas of inflammation, known as cysts.

Teenagers are most often affected by acne but it can affect anyone, from infants to the elderly. The formation of acne can be triggered by any number of factors, including hormonal changes associated with puberty, menstruation, pregnancy, and the use of certain types of birth control. 

In addition, extreme stress can also lead to acne in some individuals. Cosmetic products that are overly greasy or oily can also contribute to its development, as can some medications (in particular steroids). Acne also has a tendency to run in families. Contrary to popular belief, there is a lack of research to support claims that foods such as chocolate, nuts, and those cooked in grease or fat contribute to the development of acne.

If you or a loved one suffers from acne, you are probably well aware of its ability to have a devastating impact on one’s self-confidence and outward appearance. People who suffer from severe acne can experience severe emotional distress in addition to the visible scars it can leave behind.

Fortunately, the world of dermatology is heavily-focused on acne-related research, and many studies are available to investigate new and better methods of preventing and treating acne.

What Will Acne Clinical Trials Be like?

The types of procedures used in acne clinical trials will ultimately depend on the specific nature of the study and what aspect of acne is being studied. Provided below is a list of common procedures, tests, and assessments that may be incorporated into acne clinical trials:

  • Detailed physical examination
  • A questionnaire or face-to-face interview to provide details related to your history of acne, which may include questions related to the following:
    • Date you first developed acne
    • Noticeable triggers
    • Use of hormonal contraceptives
    • Details related to your menstrual cycle (females only)
    • Use of cosmetic and personal hygiene products, including sunscreen
    • Family history of acne
    • Use of prescription or over-the-counter medications, including vitamins, minerals, and other dietary supplements.
    • Treatments you have attempted to use for your acne
    • You may also be asked to avoid wearing lotions, perfumes, colognes, or scented make-up on the day(s) of your appointment.
    • Questionnaires to evaluate your stress level and/or emotional well-being.
    • Blood tests
    • Skin or pimple biopsy
    • Physical examination to count the number of pimples and/or cysts visible on your skin
    • Dietary logs
    • Photographs of your skin
    • Use of lotions, creams, oral medications, or laser light therapy

Typical Acne Clinical Trial Protocol:

Specific examples of clinical trials for acne might include the following:

  • A randomized trial comparing two different concentrations of a new prescription medication designed to treat acne. A trial such as this might require participants to apply a topical lotion or solution to their visible areas of acne two to three times a day for a specific length of time (e.g., 12 weeks). Participants would be observed at regular three-week intervals to document any changes in the number of their pimples. At the conclusion of the study, the two groups would be compared to determine if one particular concentration of the drug was more effective than the other.
  • A study to determine if specific dietary changes (e.g., elimination of dairy, increased intake of fiber) are effective at reducing the recurrence of acne among individuals who have received successful treatment for acne using a particular prescription medication.
  • A study designed to determine if the use of a newly-developed laser therapy is effective and safe for treating facial acne.
  • A randomized clinical trial in which individuals with acne are randomly assigned to receive antibiotic treatment with erythromycin plus a second, newly-developed antibiotic medication, or to receive treatment with erythromycin plus placebo.

A brief word about randomized trials and placebos:

Many clinical trials involve the comparison of an investigational treatment to a “standard” treatment. Some studies determine which therapy a patient receives through a process known as randomization, in which patients are randomly assigned to receive either the investigational treatment or the standard treatment.

On occasion, a trial will investigate the use of a standard treatment plus a new drug compared to standard treatment plus a placebo (such as in the fourth clinical trial example provided above). Placebos are inactive or “sham” treatments that are identical in appearance to the active treatment but have no therapeutic value.

Placebos are necessary to help determine if adverse effects that occur during the clinical trial are the result of the investigational treatment or due to some other factor. They also allow researchers to measure the effects of the active treatment and observe what would have happened without it.

In rare instances where no standard therapy exists, or when a new drug or therapy is being investigated, the investigational treatment might be compared to a placebo alone. In these types of trials, those patients who are randomized to the placebo group do not receive an active treatment.

It is important to know that placebo-only trials are only conducted when scientifically necessary and when patients have been adequately informed that they may end up receiving the placebo rather than the active treatment. It is very important to note, however, that no one should ever participate in such a placebo trial when there is a widely available and highly effective standard treatment already in existence for their particular disease or condition.

Trial Eligibility and Medical Information Needed:

The type of clinical trial you may be eligible for often depends on many factors. Therefore, it is important to know as many details as possible with regard to your specific circumstances when searching for clinical trials.  Examples of information you may want to have on hand include the following:

  • Your history of treatment for acne.
  • Your prior and current diagnoses of any other health conditions or diseases.
  • Your current medications (including vitamins, minerals, and other dietary supplements)

Suggested Search Terms:

“acne treatment,” “acne prevention,” “acne recurrence,” “acne scar,” “acne diet,” “acne infection,” and “acne medication.”

Current Search Term:

“Acne”

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A Study to Evaluate the Tolerance of an Acne Treatment in Sensitive Skin Subjects With Mild to Moderate Acne Vulgaris


Condition:   Acne Vulgaris
Intervention:   Device: Acne Mask
Sponsor:   Johnson & Johnson Consumer Inc. (J&JCI)
Active, not recruiting - verified May 2017


Venus Versa Diamondpolar Applicator Treatment Followed by AC Dual Applicator Treatment for Facial Acne Vulgaris


Condition:   Acne Vulgaris
Intervention:   Device: Venus Versa
Sponsor:   Venus Concept
Recruiting - verified September 2016


TSN2898-201 Safety and Efficacy of TSN2898 in the Treatment of Acne Vulgaris


Condition:   Acne Vulgaris
Interventions:   Drug: Vehicle;   Drug: TSN2898;   Drug: TSN2898;   Drug: TSN2898
Sponsor:   Thesan Pharmaceuticals, Inc.
Withdrawn - verified April 2017


A Study to Compare the Efficacy and Safety of Topical Administration of FMX-101 for Treatment of Moderate-to-Severe Acne


Condition:   Acne Vulgaris
Interventions:   Drug: FMX-101, 4% minocycline foam;   Drug: Vehicle Foam
Sponsor:   Foamix Ltd.
Recruiting - verified June 2016


A Study to Compare the Efficacy and Safety of Topical Administration of FMX-101 for Treatment of Moderate-to-Severe Acne


Condition:   Acne Vulgaris
Interventions:   Drug: FMX-101, 4% minocycline foam;   Drug: Vehicle Foam
Sponsor:   Foamix Ltd.
Recruiting - verified June 2016


A Study to Evaluate the Effectiveness and Tolerance of Two Acne Treatments on Subjects With Mild to Moderate Acne.


Condition:   Acne Vulgaris
Interventions:   Device: Acne Mask;   Drug: 2.5% Benzoyl Peroxide Treatment
Sponsor:   Johnson & Johnson Consumer and Personal Products Worldwide
Completed - verified April 2017


An Open-Label, Long-Term Extension Study to Evaluate the Safety of CB-03-01 Cream, 1% in Participants With Acne Vulgaris


Condition:   Acne Vulgaris
Intervention:   Drug: CB-03-01 cream, 1%
Sponsor:   Cassiopea SpA
Enrolling by invitation - verified March 2017


Efficacy, Safety, and Tolerability of S6G5T-1 and S6G5T-3 for the Treatment of Acne Vulgaris


Condition:   Acne Vulgaris
Interventions:   Drug: S6G5T-3;   Drug: S6G5T-1;   Drug: S6G5T-5;   Drug: S6G5T-6;   Drug: S6G5T-7;   Drug: S6G5T-8
Sponsors:   Sol-Gel Technologies, Ltd.;   Accelovance
Recruiting - verified September 2016


A Study to Evaluate the Safety and Efficacy of CB-03-01 Cream, 1% in Subjects With Facial Acne Vulgaris (26)


Condition:   Acne Vulgaris
Interventions:   Drug: CB-03-01 cream, 1%;   Drug: Vehicle cream
Sponsor:   Cassiopea SpA
Recruiting - verified February 2017


A Study to Evaluate the Safety and Efficacy of CB-03-01 Cream, 1% in Subjects With Facial Acne Vulgaris (25)


Condition:   Acne Vulgaris
Interventions:   Drug: CB-03-01 cream, 1%;   Drug: Vehicle cream
Sponsor:   Cassiopea SpA
Recruiting - verified March 2017


CTX-4430 for the Treatment of Moderate to Severe Facial Acne Vulgaris


Condition:   Acne Vulgaris
Interventions:   Drug: CTX-4430;   Drug: Placebo
Sponsors:   Celtaxsys, Inc.;   Clinical Network Services (CNS) Pty Ltd;   Celtaxsys Aus Pty Limited
Completed - verified August 2016


Study to Evaluate Safety & Efficacy of Sarecycline in Treatment of Acne


Condition:   Acne Vulgaris
Interventions:   Drug: Sarecycline;   Drug: Placebo
Sponsor:   Warner Chilcott
Completed - verified February 2017


Randomized, Double-blind, Placebo-controlled Study to Evaluate Safety & Efficacy of Sarecycline in Treatment of Acne


Condition:   Acne Vulgaris
Interventions:   Drug: Sarecycline;   Drug: Placebo
Sponsor:   Warner Chilcott
Completed - verified February 2017


P2 Multi-center Study of SB204 Gel in the Treatment of Acne Vulgaris


Condition:   Acne Vulgaris
Interventions:   Drug: SB204 2%;   Drug: SB204 4%;   Drug: Vehicle Gel
Sponsor:   Novan, Inc.
Completed - verified January 2017


Impact of the M22-IPL Acne Filter on Acne Vulgaris


Condition:   Acne
Intervention:   Device: M22-IPL
Sponsor:   Lumenis Ltd.
Terminated - verified January 2017


Efficacy and Safety Study of GK530G Versus CD0271 0.1% Gel and CD1579 2.5% Gel in the Treatment of Acne Vulgaris.


Condition:   Acne Vulgaris
Interventions:   Drug: GK530G;   Drug: CD0271;   Drug: CD1579
Sponsor:   Galderma R&D
Completed - verified February 2017


Efficacy and Safety Study of 2 Different Concentrations of CD1579 Gels Versus Vehicle in the Treatment of Acne Vulgaris.


Condition:   Acne Vulgaris
Interventions:   Drug: CD1579 2.5%;   Drug: CD1579 5%;   Drug: Vehicle
Sponsor:   Galderma R&D
Completed - verified February 2017


A Long Term Study of GK530G in Subjects With Acne Vulgaris


Condition:   Acne Vulgaris
Intervention:   Drug: GK530G
Sponsor:   Galderma R&D
Completed - verified February 2017


A Study to Evaluate the Safety and Efficacy of Tazarotene Foam, 0.1%, in Subjects With Common Facial Acne


Condition:   Acne Vulgaris
Interventions:   Drug: Tazarotene Foam;   Drug: Vehicle Foam
Sponsors:   Stiefel, a GSK Company;   GlaxoSmithKline
Completed - verified March 2017


A Study to Evaluate the Bioavailability of Tazarotene Foam, 0.1%, and Tazorac Gel, 0.1%, in Subjects With Acne Vulgaris


Condition:   Acne Vulgaris
Interventions:   Drug: Tazarotene;   Drug: Tazaroc Gel
Sponsors:   Stiefel, a GSK Company;   GlaxoSmithKline
Completed - verified October 2016


A Study to Evaluate Tolerability of Two Topical Drug Products in the Treatment of Facial Acne


Condition:   Acne Vulgaris
Interventions:   Drug: Clindamycin and benzoyl peroxide gel (Duac® Topical Gel);   Drug: benzoyl peroxide and adapalene gel (EPIDUO™ Gel)
Sponsors:   Stiefel, a GSK Company;   GlaxoSmithKline
Completed - verified October 2016


A Comparative Study of the Tolerability of Two Combination Therapies for the Treatment of Acne


Condition:   Acne Vulgaris
Interventions:   Drug: BENZOYL PEROXIDE/ CLINDAMYCIN;   Drug: BENZOYL PEROXIDE/ ADAPALENE
Sponsors:   Stiefel, a GSK Company;   GlaxoSmithKline
Completed - verified October 2016


Comparative Antimicrobial Efficacy of Two Topical Acne Therapies for the Treatment of Facial Acne


Condition:   Acne
Interventions:   Drug: Duac;   Drug: Ziana gel
Sponsors:   Stiefel, a GSK Company;   GlaxoSmithKline
Completed - verified May 2017


Trial of Clindamycin / Benzoyl Peroxide Gel in Subjects With Acne


Condition:   Acne Vulgaris
Interventions:   Drug: clindamycin / benzoyl peroxide gel;   Drug: clindamycin gel;   Drug: BPO gel;   Drug: vehicle gel
Sponsors:   Stiefel, a GSK Company;   Rho, Inc.;   Quintiles, Inc.;   GlaxoSmithKline
Completed - verified October 2016


The Treatment of Acne Vulgaris With Radiofrequency Device


Condition:   Acne Vulgaris
Intervention:   Device: Radio Frequency
Sponsor:   Alma Lasers
Withdrawn - verified September 2007

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