Hepatitis B



Ledipasvir/Sofosbuvir for Hepatitis B Virus Infection


Condition:   Hepatitis B
Intervention:   Drug: Ledipasvir-Sofosbuvir
Sponsors:   University of Maryland;   Gilead Sciences;   KlinEra Global Services
Not yet recruiting


TDF Medicine to Prevent Mother to Child Transmission of Hepatitis B


Condition:   Hepatitis B
Intervention:   Drug: Tenofovir Disoproxil Fumarate
Sponsor:   University of Oxford
Not yet recruiting


A Nation-wide Hospital-based Hepatitis B Registry:China Registry of Hepatitis B


Condition:   Chronic Hepatitis B
Intervention:  
Sponsors:   Beijing Friendship Hospital;   Beijing YouAn Hospital;   First Hospital of Jilin University;   Henan Provincial Hospital;   Beijing Ditan Hospital;   First Affiliated Hospital of Xinjiang Medical University;   The First Hospital of Lanzhou University;   The Second Affiliated Hospital of Chongqing Medical University;   West China Hospital;   Taiyuan No.3 Hospital;   Hebei Medical University Third Hospital;   Shengjing Hospital;   Tianjin Third Central Hospital;   Peking University First Hospital;   LanZhou University;   Peking Union Medical College Hospital;   The Affiliated Hospital Of Southwest Medical University;   Shanghai Public Health Clinical Center;   Ruijin Hospital;   First Affiliated Hospital Xi'an Jiaotong University;   Xiangya Hospital of Central South University;   Beijing Tiantan Hospital,Capital Medical University;   Wuhan University;   The First Affiliated Hospital of Kunming Medical College;   The Affiliated Hospital of Xuzhou Medical University;   The Affiliated Hospital of Yanbian University;   First Affiliated Hospital of Chongqing Medical University;   The Fouth Hospital of Qinghai province;   Affiliated Hospital of Weifang Medical University;   Hunan Provincial People's Hospital;   The Second Hospital of Hebei Medical University;   Xixi Hospital of Hangzhou;   General Hospital of Ningxia Medical University;   Union Hospital,Tong Ji Medical College,Huazhong University of Science and Technology;   Xinjiang Uygur Autonomous Region Traditional Chinese Medicine Hospital;   Peking University People's Hospital;   Nanfang Hospital of Southern Medical University;   The Affiliated Hospital Of Guizhou Medical University;   Guizhou Provincial People's Hospital;   Hainan General Hospital;   The Second Hospital of Shandong University;   The First Affiliated Hospital of Shanxi Medical University;   Fifth Hospital of Shijiazhuang City;   Yan'an University Affiliated Hospital;   Infectious Disease Hospital of Wuhai;   Affiliated Hospital, Logistics University of People's Armed Police Force;   People's Hospital of Changji Hui Autonomous Prefecture,Xinjiang
Recruiting


Tenofovir in Early Pregnancy to Prevent Mother-to-child Transmission of Hepatitis B Virus


Condition:   Hepatitis B
Intervention:   Drug: Tenofovir Disoproxil Fumarate
Sponsors:   Johns Hopkins Bloomberg School of Public Health;   Thrasher Research Fund;   Shoklo Malaria Research Unit;   Chiang Mai University
Not yet recruiting


The Safety and Dose-range Study of Metacavir Enteric-coated Capsules in Patients With Chronic Hepatitis B


Condition:   Chronic Hepatitis B
Interventions:   Drug: Metacavir Enteric-coated Capsules 80mg;   Drug: Metacavir Enteric-coated Capsules 160mg;   Drug: Metacavir Enteric-coated Capsules 320mg;   Drug: Metacavir Enteric-coated Capsules Placebo 240mg;   Drug: Metacavir Enteric-coated Capsules Placebo 160mg;   Drug: Metacavir Enteric-coated Capsules Placebo 320mg;   Drug: Adefovir Dipivoxil Capsule10mg;   Drug: Adefovir Dipivoxil Capsule Placebo 10mg
Sponsor:   Guangzhou Yipinhong Pharmaceutical CO.,LTD
Recruiting


Mechanisms Associated With Favorable Responses to Peginterferon-Alpha Add-on Therapy Following Long-term Nucleos(t)Ide Analogue Treatment in Patients With Chronic Hepatitis B


Condition:   Chronic Hepatitis B
Intervention:   Drug: Peginterferon alfa-2a
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting


Safety and Efficacy Study of NVR 3-778 in Healthy Volunteers and Hepatitis B Patients


Condition:   Chronic Hepatitis B
Interventions:   Drug: NVR 3-778;   Drug: Placebo for NVR 3-778;   Drug: Pegasys
Sponsor:   Novira Therapeutics, Inc.
Completed


A Study of the Immune Response to Heplisav in Healthy Older Adults


Condition:   Hepatitis B
Intervention:   Biological: HEPLISAV
Sponsors:   Dynavax Technologies Corporation;   Baylor Research Institute
Completed


Study for Consolidation Period of Chronic Hepatitis B


Condition:   Hepatitis B
Intervention:  
Sponsor:   Tainan Municipal Hospital
Active, not recruiting


Peg-interferon ADDed to an Ongoing Nucleos(t)Ide Based Treatment in Patients With Chronic Hepatitis B to Induce Decrease of HBs-Antigen


Condition:   Chronic Hepatitis B
Intervention:   Drug: Pegylated interferon alfa-2a plus nucleos(t)ide(s)
Sponsors:   Johannes Gutenberg University Mainz;   Roche Pharma AG
Active, not recruiting


Combination Entecavir and Peginterferon Therapy in HBeAg-Positive Immune-Tolerant Adults With Chronic Hepatitis B


Condition:   Hepatitis B
Intervention:   Drug: Entecavir and peginterferon
Sponsors:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   University of Pittsburgh;   National Center for Research Resources (NCRR)
Completed


HBRN: Immune Regulation and Costimulation in Natural History of Chronic Hepatitis B


Condition:   Hepatitis B
Intervention:  
Sponsors:   University of Pennsylvania;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Active, not recruiting


Hepatitis B Research Network Pediatric Cohort Study (HBRN)


Condition:   Hepatitis B
Intervention:  
Sponsors:   University of Pittsburgh;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting


Hepatitis B Research Network Adult Cohort Study


Condition:   Hepatitis B
Intervention:  
Sponsors:   University of Pittsburgh;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   National Center for Research Resources (NCRR)
Recruiting


Duration of Long-term Immunity After Hepatitis B Virus Immunization


Condition:   Hepatitis B
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Completed


Study to Compare the Efficacy of GSK Biologicals' Adjuvants in Combination With the Antigen of the Hepatitis B Vaccine


Condition:   Hepatitis B
Interventions:   Biological: Engerix-B™;   Biological: Fendrix™;   Biological: GSK Biologicals' Hepatitis B vaccines (GSK223192A);   Biological: HBsAg (Booster injection)
Sponsor:   GlaxoSmithKline
Completed


Increasing Hepatitis B Screening Among Korean Church Attendees


Condition:   Hepatitis B
Intervention:   Behavioral: Educational Small Group Session
Sponsors:   University of California, Los Angeles;   National Institutes of Health (NIH);   National Cancer Institute (NCI)
Completed


Challenge Dose of Hepatitis B Vaccine in Subjects Who Previously Received Engerix™-B Vaccine


Condition:   Hepatitis B
Intervention:   Biological: Engerix™-B
Sponsor:   GlaxoSmithKline
Completed


Long-term Persistence of Immunity Against Hepatitis B in 7-8 Years Old Children After Hepatitis B Vaccination.


Condition:   Hepatitis B Vaccine
Intervention:   Biological: Engerix™-B Kinder
Sponsor:   GlaxoSmithKline
Completed


Immune Response to Hepatitis B Vaccine Challenge Dose in Subjects Who Received a Primary Neonatal Hepatitis B Vaccine.


Condition:   Hepatitis B
Intervention:   Biological: Engerix™-B
Sponsor:   GlaxoSmithKline
Completed


Hepatitis B Vaccine Predialysis/Dialysis Study (V232-060)


Condition:   Hepatitis B Virus Infection
Interventions:   Biological: Comparator: modified process hepatitis B vaccine;   Biological: Comparator: ENGERIX-B™
Sponsor:   Merck Sharp & Dohme Corp.
Completed



LT F-up Study 16-20 Yrs After Vaccine Dose of Hepatitis B With/Without HBIg in Newborns to HBeAg+ Mothers


Condition:   Hepatitis B
Interventions:   Biological: Engerix™ -B;   Biological: Hepatitis B immunoglobulin (HBIg)
Sponsor:   GlaxoSmithKline
Completed


Follow-up Study 16-20 Years After Primary Vaccination Against Hepatitis B of Newborns From HBeAg+ & HBsAg+ Mothers


Condition:   Hepatitis B
Intervention:   Biological: Engerix™-B
Sponsor:   GlaxoSmithKline
Completed


Effectiveness of Two Hepatitis B Vaccines in HIV-negative Youths


Condition:   Hepatitis B
Interventions:   Biological: Recombivax;   Biological: Twinrix
Sponsors:   University of North Carolina, Chapel Hill;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Institute on Drug Abuse (NIDA);   National Institute of Mental Health (NIMH);   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Completed

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