Diabetic Neuropathy



0.075% Capsaicin Lotion for the Treatment of Painful Diabetic Neuropathy


Condition:   Peripheral Diabetic Neuropathy
Interventions:   Drug: 0.075% Capsaicin Lotion;   Drug: placebo
Sponsor:   Thammasat University
Recruiting - verified April 2017


Graded Exposure in Patients With Painful Diabetic Neuropathy


Conditions:   Painful Diabetic Neuropathy;   Diabetic Neuropathies, Painful;   Neuralgia, Diabetic
Intervention:   Behavioral: Graded Exposure
Sponsor:   Maastricht University Medical Center
Not yet recruiting - verified February 2017


Corneal Confocal Microscopy in Patients With Type 1 Diabetes


Condition:   Diabetic Neuropathies
Interventions:   Device: Corneal confocal microscopy;   Procedure: Skin biopsy;   Procedure: Nerve conduction study;   Other: Blood draw
Sponsor:   Albert Einstein College of Medicine, Inc.
Not yet recruiting - verified February 2017


The Effect of Random Vibrations on Perception and Balance


Condition:   Diabetic Neuropathy
Intervention:   Device: Vibrating insoles 'on'
Sponsor:   University Medical Center Groningen
Completed - verified December 2016


Evaluation of Rocker sOles in Diabetis


Condition:   Diabetic Neuropathy
Interventions:   Device: Rocker sole shoes;   Device: Normal shoes
Sponsor:   University Hospital, Brest
Completed - verified September 2016


A Study to Evaluate PEMF Therapy on Experimentally Inducted Pain in Subjects With Painful Peripheral Diabetic Neuropathy


Condition:   Painful Peripheral Diabetic Neuropathy
Intervention:   Device: Provant
Sponsor:   Regenesis Biomedical, Inc.
Completed - verified October 2016


Efficacy of Near Infrared Phototherapy in Type 2 Diabetic Neuropathy


Condition:   Neuropathy
Interventions:   Other: Infrared Phototherapy;   Other: Sham
Sponsors:   Healthlight, LLC;   Clin-Assist, LLC;   Midwest Medical Research
Terminated - verified February 2017


Effects of a Personalized Intervention in Gait Velocity and Functionality in Diabetic Neuropathic Patients


Condition:   Diabetic Neuropathies
Intervention:   Other: Physical therapy intervention
Sponsors:   University of Sao Paulo General Hospital;   Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.
Not yet recruiting - verified May 2016


Nociceptive Pain Fiber Response


Condition:   Painful Peripheral Diabetic Neuropathy
Intervention:   Device: Provant Therapy System
Sponsor:   Regenesis Biomedical, Inc.
Completed - verified December 2016


The Efficacy and Safety of Clonidine Hydrochloride Topical Gel, vs Clonidine Hydrochloride Gel Comparator to Treat Painful Diabetic Neuropathy


Conditions:   Painful Diabetic Neuropathy;   Diabetic Neuropathy;   Neuropathy
Interventions:   Drug: Clonidine Hydrochloride Topical Gel, 0.1%;   Drug: Clonidine Hydrochloride Gel Comparator
Sponsor:   BioDelivery Sciences International
Completed - verified November 2016


Phase 3 Gene Therapy for Painful Diabetic Neuropathy


Conditions:   Painful Diabetic Neuropathy;   Diabetic Neuropathy, Painful
Interventions:   Genetic: VM202;   Genetic: placebo
Sponsors:   ViroMed Co., Ltd. dba VM BioPharma;   MedTech Consultants Inc.
Recruiting - verified May 2017


Activity for Diabetic Polyneuropathy


Condition:   Diabetic Neuropathy
Interventions:   Behavioral: Standard Care Counseling;   Behavioral: Supervised Exercise and Counseling
Sponsors:   University of Utah;   University of Kansas Medical Center
Recruiting - verified August 2016


A Clinical Trial To Evaluate PF-05089771 On Its Own And As An Add-On Therapy To Pregabalin (Lyrica) For The Treatment Of Pain Due To Diabetic Peripheral Neuropathy (DPN)


Condition:   Diabetic Neuropathy, Painful
Interventions:   Drug: PF-05089771 150 mg;   Drug: Matched placebo for PF-05089771 150 mg and pregabalin 300 mg;   Drug: Pregabalin 300 mg;   Drug: PF-05089771 150 mg + Pregabalin 300 mg
Sponsor:   Pfizer
Completed - verified March 2017


Characteristics of Popliteal Sciatic Nerve Block in Patients With and Without Diabetic Neuropathy


Condition:   Diabetic Neuropathy
Intervention:   Procedure: US-guided sciatic block at the popliteal crease (30 mL1:1 mixture of lidocaine 1% and bupivacaine 0.5%)
Sponsor:   Centre Hospitalier Universitaire Vaudois
Completed - verified September 2016


Safety, Tolerability and Preliminary Efficacy of AZD5213 in Combination With Pregabalin in Subjects With PDN and Good Pain Reporting Ability


Condition:   Diabetic Neuropathy, Painful; Diabetic Neuropathies
Interventions:   Drug: AZD5213 + pregabalin;   Drug: Placebo;   Drug: pregabalin capsules
Sponsor:   AstraZeneca
Completed - verified August 2016


Training "Pain Connoisseurs" for Efficient Analgesic Proof-of-Concept Studies


Condition:   Painful Diabetic Neuropathy (PDN)
Interventions:   Other: EPT;   Drug: Drug Placebo Administration;   Other: C
Sponsors:   Analgesic Solutions;   Grünenthal GmbH
Completed - verified July 2016


Study to Evaluate MK-6096 in the Treatment of Painful Diabetic Neuropathy (PDN) in Adults (MK-6096-021)


Condition:   Diabetic Neuropathy, Painful
Interventions:   Drug: MK-6096;   Drug: Placebo
Sponsor:   Merck Sharp & Dohme Corp.
Completed - verified June 2016


Safety and Efficacy Study for the Treatment of Painful Diabetic Neuropathy


Condition:   Painful Diabetic Neuropathies
Interventions:   Genetic: Low Dose: 16 mg VM202;   Genetic: High Dose: 32 mg VM202;   Genetic: Control- Placebo (normal saline)
Sponsor:   ViroMed Co., Ltd. dba VM BioPharma
Completed - verified September 2016


Efficacy and Safety of TAK-583 in Subjects With Diabetic Peripheral Neuropathy


Condition:   Diabetic Neuropathies
Interventions:   Drug: TAK-583;   Drug: TAK-583;   Drug: TAK-583;   Drug: Placebo
Sponsor:   Takeda
Completed - verified June 2016


Efficacy and Safety Study of ARC-4558 for Management of Pain Associated With Painful Diabetic Neuropathy


Condition:   Painful Diabetic Neuropathy
Interventions:   Drug: Placebo Gel;   Drug: Clonidine Topical Gel (ARC-4558)
Sponsor:   Arcion Therapeutics Inc
Completed - verified September 2016


Efficacy Study With 500 mg QD of TRO19622 vs Placebo in Patients With Painful Peripheral Diabetic Neuropathy


Condition:   Diabetic Neuropathy
Interventions:   Drug: Experimental;   Drug: Placebo comparator
Sponsors:   Hoffmann-La Roche;   Ergomed GmbH
Completed - verified November 2016


Effects of Pulsatile Intravenous Insulin Delivery on Diabetic Neuropathy in pATIENTS (Pts) With Type 1 and Type 2 Diabetes


Condition:   Diabetic Neuropathy
Interventions:   Procedure: Placebo;   Procedure: Pulsatile IV insulin delivery (humalog, humulin, novolog)
Sponsors:   Florida Atlantic University;   Advanced Diabetes Treatment Centers;   Global Infusions
Withdrawn - verified August 2016


Effects of Pulsatile Insulin Delivery on Diabetic Neuropathy in Patients With Types 1 and 2 Diabetes Mellitus


Condition:   Diabetes Mellitus, With Complications
Interventions:   Procedure: Effect of Pulsatile IV insulin on diabetic neuropathy;   Procedure: Effect of Pulsatile IV Insulin on diabetic neuropathy
Sponsors:   Florida Atlantic University;   Advanced Diabetes Treatment Centers;   Global Infusions
Terminated - verified August 2016


The Effect of Ruboxistaurin on Small Fiber Function


Condition:   Diabetic Neuropathy
Intervention:   Drug: Ruboxistaurin
Sponsor:   Chromaderm, Inc.
Completed - verified July 2016


Safety and Efficacy of Dextromethorphan and Quinidine in the Treatment of the Pain of Diabetic Neuropathy


Conditions:   Pain;   Diabetic Neuropathy
Intervention:   Drug: Neurodex
Sponsor:   Avanir Pharmaceuticals
Completed - verified July 2016

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