Bone Cancer



The Impact of Cancer on the Physical and Psychosocial Well-being Among Childhood Osteosarcoma Survivors


Condition:   Childhood Osteosarcoma
Intervention:   Other: Questionnaires
Sponsor:   The University of Hong Kong
Recruiting


Characteristics and Mechanism of Denosumab-treated Giant Cell Tumor of Bone


Condition:   Giant Cell Tumor of Bone
Intervention:   Drug: Denosumab
Sponsor:   Hebei Medical University Third Hospital
Recruiting


Biology of Osteosarcoma (BOOST) Registry and Biobank


Condition:   Osteosarcoma
Intervention:  
Sponsor:   University of Minnesota - Clinical and Translational Science Institute
Recruiting


Apatinib Second Line Treatment for Advanced Osteosarcoma and Soft Tissue Sarcomas ,Openting ,Single Center, One-armed Clinical Study.


Condition:   Osteosarcoma, Advanced
Intervention:   Drug: Apatinib
Sponsors:   Henan Cancer Hospital;   Jiangsu HengRui Medicine Co., Ltd.
Recruiting


Clinical Trial Evaluating Metronomic Chemotherapy in Patients With Metastatic Osteosarcoma


Condition:   Osteosarcoma
Interventions:   Drug: Cyclophosphamide;   Drug: Methotrexate
Sponsor:   Grupo de Apoio ao Adolescente e a Crianca com Cancer
Recruiting


A Study of Pembrolizumab in Patients With Relapsed Or Metastatic Osteosarcoma Not Eligible for Curative Surgery


Condition:   Osteosarcoma
Intervention:   Drug: Pembrolizumab
Sponsors:   Oslo University Hospital;   Italian Sarcoma Group;   Merck Sharp & Dohme Corp.
Recruiting


A Phase II Trial of Avelumab in Patients With Recurrent or Progressive Osteosarcoma


Condition:   Osteosarcoma
Interventions:   Drug: Avelumab;   Other: Questionnaires
Sponsors:   St. Jude Children's Research Hospital;   National Cancer Institute (NCI)
Recruiting


The Application of Personalized Titanium Plate in the Bone Tumors Around the Knee


Condition:   Bone Tumors
Intervention:   Procedure: Personalized titanium plate
Sponsors:   Guangzhou General Hospital of Guangzhou Military Command;   Medical Center of Assessment, Prevention and Treatment of Bone & Joint Diseases, Guangdong, China;   The First Affiliated Hospital of Guangzhou Medical University
Completed


Pre-Surgical Supervised Exercise for Bone Cancer Patients


Condition:   Malignant Neoplasms of Bone and Articular Cartilage
Intervention:   Behavioral: Supervised Exercise Program
Sponsor:   M.D. Anderson Cancer Center
Recruiting


Phase II Trial for the Treatment of Relapsed Osteosarcoma


Condition:   OSTEOSARCOMA
Interventions:   Drug: Gemcitabine and Docetaxel;   Drug: Ifosfamide
Sponsor:   Italian Sarcoma Group
Recruiting


Humanized Monoclonal Antibody 3F8 (Hu3F8) With Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) in the Treatment of Recurrent Osteosarcoma


Condition:   Recurrent Osteosarcoma
Interventions:   Biological: humanized anti-GD2 antibody;   Drug: GM-CSF
Sponsors:   Memorial Sloan Kettering Cancer Center;   Children's Hospital Los Angeles;   M.D. Anderson Cancer Center
Recruiting


Glembatumumab Vedotin in Treating Patients With Recurrent or Refractory Osteosarcoma


Condition:   Recurrent Osteosarcoma
Interventions:   Drug: Glembatumumab Vedotin;   Other: Laboratory Biomarker Analysis;   Other: Pharmacological Study
Sponsor:   National Cancer Institute (NCI)
Active, not recruiting


A Eurosarc Study of Mifamurtide in Advanced Osteosarcoma (MEMOS)


Condition:   Osteosarcoma
Interventions:   Drug: Mifamurtide;   Drug: Ifosfamide
Sponsors:   University of Oxford;   Millennium: The Takeda Oncology Company;   National Institute for Health Research, United Kingdom;   Oxford University Hospitals NHS Trust;   European Commission
Completed


Eribulin Mesylate in Treating Patients With Recurrent or Refractory Osteosarcoma


Condition:   Recurrent Osteosarcoma
Interventions:   Drug: Eribulin Mesylate;   Other: Pharmacological Study
Sponsor:   National Cancer Institute (NCI)
Completed


Investigation of [6R] 5,10-methylenetetrahydrofolate as Rescue Therapy for Osteosarcoma Patients Treated With HDMTX.


Condition:   Osteosarcoma
Interventions:   Drug: Leucovorin;   Drug: [6R] 5,10-methylenetetrahydrofolate
Sponsor:   Isofol Medical AB
Completed


Combination of External Beam Radiotherapy With 153Sm-EDTMP to Treat High Risk Osteosarcoma


Condition:   Metastatic Osteosarcoma
Interventions:   Drug: Sm-EDTMP;   Other: Autologous Stem Cell Infusion;   Radiation: External Beam Radiotherapy
Sponsor:   Sidney Kimmel Comprehensive Cancer Center
Recruiting


Study of Pazopanib in the Treatment of Osteosarcoma Metastatic to the Lung


Conditions:   Osteosarcoma;   Metastatic Osteosarcoma
Intervention:   Drug: pazopanib
Sponsors:   Vector Oncology;   GlaxoSmithKline
Active, not recruiting


Clinical Trial of Lithium Carbonate Combined With Neo-adjuvant Chemotherapy to Treat Osteosarcoma


Condition:   Osteosarcoma
Interventions:   Drug: Lithium Carbonate;   Drug: Placebo
Sponsors:   Sun Yat-sen University;   Qilu Hospital of Shandong University;   Nanfang Hospital of Southern Medical University;   Shenzhen Second People's Hospital;   Guangdong Provincial Hospital of Traditional Chinese Medicine;   Shanghai 6th People's Hospital
Recruiting


ABCB1/P-glycoprotein Expression as Biologic Stratification Factor for Patients With Non Metastatic Osteosarcoma


Condition:   Osteosarcoma
Interventions:   Drug: Mifamurtide arm;   Other: 3 drugs arm
Sponsor:   Italian Sarcoma Group
Recruiting


Surveillance Study of Patients With Newly Diagnosed Osteosarcoma


Condition:   Osteosarcoma
Intervention:   Drug: Mifamurtide
Sponsor:   Millennium Pharmaceuticals, Inc.
Terminated


Outpatient Administration of High Dose Methotrexate (HD MTX) in Patients With Osteosarcoma


Condition:   Osteosarcoma
Intervention:   Drug: High Dose Methotrexate
Sponsor:   The Hospital for Sick Children
Completed


Adjuvant High-Dose Thiotepa and Stem Cell Rescue Associated With Conventional Chemotherapy in Relapsed Osteosarcoma


Condition:   Osteosarcoma
Intervention:   Drug: Thiotepa
Sponsor:   Centre Leon Berard
Active, not recruiting


A Placebo-Controlled Study of Saracatinib (AZD0530) in Patients With Recurrent Osteosarcoma Localized to the Lung


Condition:   Osteosarcoma
Interventions:   Drug: Saracatinib;   Drug: Placebo
Sponsors:   Sarcoma Alliance for Research through Collaboration;   AstraZeneca
Active, not recruiting


Combination Chemotherapy, PEG-Interferon Alfa-2b, and Surgery in Treating Patients With Osteosarcoma


Conditions:   Localized Osteosarcoma;   Metastatic Osteosarcoma
Interventions:   Drug: doxorubicin hydrochloride;   Drug: cisplatin;   Drug: methotrexate;   Procedure: therapeutic conventional surgery;   Biological: peginterferon alfa-2b;   Drug: ifosfamide;   Drug: etoposide;   Procedure: quality-of-life assessment;   Other: questionnaire administration
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI);   University College London Hospitals
Active, not recruiting


Inhalation SLIT Cisplatin (Liposomal) for the Treatment of Osteosarcoma Metastatic to the Lung


Condition:   Osteosarcoma Metastatic
Intervention:   Drug: Cisplatin liposomal
Sponsor:   Insmed Incorporated
Completed

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