Major Depression



A Study to Evaluate the Safety and Efficacy of TS-121 as an Adjunctive Treatment for Major Depressive Disorder


Condition:   Major Depressive Disorder
Interventions:   Drug: TS-121 10 mg;   Drug: TS-121 50 mg;   Drug: Placebo
Sponsor:   Taisho Pharmaceutical R&D Inc.
Recruiting - verified May 2017


Assessment of Hedonic and Motivational States in Major Depression ( MOODDIS)


Condition:   Major Depression
Intervention:   Behavioral: Computer-based tasks
Sponsor:   Institut National de la Santé Et de la Recherche Médicale, France
Not yet recruiting - verified December 2016


Open Label Ketamine Treatment for Major Depressive Disorder in Veterans


Condition:   Major Depressive Disorder
Intervention:   Drug: Ketamine
Sponsor:   VA Connecticut Healthcare System
Recruiting - verified February 2017


Efficacy of H7-Coil DTMS Compared to H1-Coil DTMS in Subjects With Major Depression Disorder (MDD)


Condition:   Major Depressive Disorder (MDD)
Interventions:   Device: H7-Coil;   Device: H1-Coil
Sponsor:   Brainsway
Not yet recruiting - verified January 2017


A Study to Evaluate SAGE-217 in Subjects With Moderate to Severe Major Depressive Disorder


Condition:   Major Depression
Interventions:   Drug: SAGE-217;   Drug: Placebo
Sponsor:   Sage Therapeutics
Recruiting - verified April 2017


Vortioxetine for the Treatment of Major Depression and Co-morbidities After Traumatic Brain Injury (TBI)


Conditions:   TBI;   Major Depression
Interventions:   Drug: Vortioxetine;   Drug: Placebo
Sponsors:   Johns Hopkins University;   Takeda
Withdrawn - verified September 2016


Selenium as Augmentation Treatment for Sertraline Resistant Major Depression


Condition:   Major Depression
Interventions:   Dietary Supplement: selenium supplementation;   Dietary Supplement: placebo
Sponsor:   University of Sao Paulo General Hospital
Recruiting - verified May 2017


Impact of tDCS on Emotional Processing in Major Depression


Condition:   Major Depressive Disorder
Intervention:   Device: transcranial direct current stimulation
Sponsor:   Hôpital le Vinatier
Not yet recruiting - verified June 2016


Antidepressant Effects of the Glycine Receptor Antagonist AV-101 (4-chlorokynurenine) in Major Depressive Disorder


Condition:   Major Depression
Interventions:   Drug: AV 101 (4-Chlorokynurenine);   Other: Placebo
Sponsor:   National Institute of Mental Health (NIMH)
Recruiting - verified March 2, 2017


Music Therapy for Major Depressive Disorder Residual Symptoms


Condition:   Major Depressive Disorder
Interventions:   Behavioral: Music therapy;   Other: Usual Treatment
Sponsor:   Instituto Nacional de Psiquiatría Dr. Ramón de la Fuente
Recruiting - verified October 2016


Evaluation of the Safety of Adjunct Brexpiprazole in Elderly Patients With Major Depressive Disorder and an Inadequate Response to Antidepressant Treatment


Condition:   Major Depression Disorder
Intervention:   Drug: Adjunct brexpiprazole
Sponsor:   H. Lundbeck A/S
Completed - verified June 2016


Blood Biomarkers in Major Depression


Condition:   Major Depressive Disorder
Interventions:   Other: blood prelevement;   Other: psychometric data collection
Sponsor:   Assistance Publique Hopitaux De Marseille
Active, not recruiting - verified July 2016


Biomarkers of Fast Acting Therapies in Major Depression


Condition:   Major Depressive Disorder
Intervention:   Drug: Ketamine
Sponsors:   University of California, Los Angeles;   National Institute of Mental Health (NIMH)
Recruiting - verified November 2016


Wake and Light Therapy to In-patients With Major Depression: Efficacy, Predictors and Patient Experiences


Condition:   Major Depression
Intervention:   Behavioral: wake therapy
Sponsor:   University of Aarhus
Completed - verified October 2016


Supplemental Transcranial Magnetic Stimulation (TMS) vs. Standard Medication Monotherapy for Treating Major Depression: An Exploratory Field Study


Condition:   1. Major Depressive Disorder
Interventions:   Device: Supplemental TMS;   Drug: Standard Medication Monotherapy
Sponsors:   Sheppard Pratt Health System;   Central Michigan University
Withdrawn - verified April 2017


Mental Health Telemetry for Self-Management in Major Depression


Condition:   Major Depressive Disorder
Intervention:   Device: MHT
Sponsors:   Sunnybrook Health Sciences Centre;   Canadian Institutes of Health Research (CIHR)
Completed - verified November 2016


Brain Inflammation in Major Depressive Disorder Background


Condition:   Major Depression
Intervention:  
Sponsor:   National Institute of Mental Health (NIMH)
Recruiting - verified September 22, 2016


Comparison of Venlafaxine and Fluoxetine in the Treatment of Postmenopausal Women With Major Depression


Condition:   Major Depression
Interventions:   Drug: venlafaxine;   Drug: fluoxetine
Sponsor:   Capital Medical University
Recruiting - verified August 2016


Open Trial of Duloxetine in Outpatients With Irritable Bowel Syndrome Symptoms and Co-Morbid Major Depression


Conditions:   Major Depression;   Irritable Bowel Syndrome
Intervention:   Drug: Duloxetine
Sponsors:   New York State Psychiatric Institute;   Eli Lilly and Company
Completed - verified December 2012


Brief Multifamily Psychoeducation for Families of Patients With Chronic Major Depression


Condition:   Major Depressive Disorder
Intervention:   Behavioral: Family psychoeducation
Sponsor:   Nagoya City University
Completed - verified April 2017


An Efficacy, Safety and Tolerability of Cariprazine as an Adjunctive Treatment to Antidepressant Therapy (ADT) in Patients With Major Depressive Disorder (MDD)


Condition:   Major Depressive Disorder
Interventions:   Drug: Cariprazine;   Drug: Placebo
Sponsors:   Forest Laboratories;   Gedeon Richter Ltd.
Active, not recruiting - verified June 2016


Potential Use Of Brain Network Activation Analysis to Diagnose Major Depression


Condition:   Major Depressive Disorder
Intervention:  
Sponsors:   Massachusetts General Hospital;   ElMindA Ltd
Terminated - verified March 2017


Study of Transcranial Direct Current Stimulation (tDCS) as add-on Treatment for Resistant Major Depression


Condition:   Resistant Major Depression
Intervention:   Device: transcranial Direct Current Stimulation (tDCS)
Sponsors:   Centre Hospitalier Universitaire de Besancon;   H. Lundbeck A/S
Completed - verified August 2016


Cysteamine Therapy for Major Depressive Disorder


Condition:   Major Depressive Disorder
Intervention:   Drug: cysteamine bitartrate
Sponsor:   Icahn School of Medicine at Mount Sinai
Terminated - verified April 2017


A Double Blind, Randomized Placebo Controlled Study of the Efficacy, Safety and of Quetiapine Fumarate (Seroquel®) as Potentiation SSRI's, and SNRI's Treatment in Major Depression With Anxiety


Condition:   Major Depression With Comorbid Anxiety Symptoms
Intervention:   Drug: Quetiapine Fumarate (Seroquel®)
Sponsor:   Dr Alexander McIntyre Inc.
Completed - verified July 2016

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