Smoking Cessation

About Smoking Cessation Clinical Trials (Click to Open)

Join Clinical Trials for Smoking Cessation

Smoking CessationGeneral Purpose

Smoking is the single-most preventable cause of death. Smoking has negative effects on nearly every part of the body, and second-hand smoke (or environmental tobacco smoke) can also cause negative health effects to individuals who do not smoke.

Although smoking rates have declined over the past few decades, it is still a widespread behavior and costs the American economy tens of billions of dollars in health-related costs each year.

As such, there is an abundant amount of research currently ongoing to investigate new methods of helping individuals stop smoking, as well as to better understand the ways in which nicotine (the addictive component of cigarettes and other tobacco products) exerts its effects on the body and leads to addiction.  

What Will Smoking Cessation Clinical Trials Be Like?

When participating in clinical trials for smoking cessation, a few common tests and procedures may be involved; however, the ultimate design of the particular study will determine which specific procedures you will undergo.

For example, studies designed to test a new drug that can help reduce the urge to smoke may involve repeated blood tests to measure both drug and nicotine levels in the blood. Urine tests may also be required in order to evaluate the amount and type of smoking-related chemicals in the urine.

Some studies may involve constant daily or weekly interaction with a “coach” who provides emotional support to the study participant in an effort to aid in the process of smoking cessation.

Other studies may require that you maintain a written or electronic diary of thoughts, feelings, how much you smoke, and nicotine-withdrawal symptoms. Some studies may require repeated physical fitness testing, or heart/lung function testing over a period of months or years in order to see how physical health improves following smoking cessation.

Typical Clinical Trials for Smoking Cessation Protocol:

There is a broad range of possible trials related to smoking cessation. Below are a few Smoking Cessation clinical trialsexamples of possible types of studies:

  • A trial to determine if a new antidepressant medication is more effective than current treatments at helping smokers quit.
  • A study designed to determine if increased physical activity improves cessation rates among smokers engaged in smoking cessation therapy.
  • A trial to investigate new therapies to help alleviate the symptoms associated with nicotine withdrawal during the process of smoking cessation.
  • A study to determine if certain genetic factors influence an individual’s ability to successfully quit smoking.
  • A study designed to evaluate heart function after taking medication to assist with smoking cessation.
  • A study to determine the effectiveness of new nicotine replacement therapies (i.e., skin patches or gum) in helping smokers to quit.

Suggested Search Terms:

“Smoking Cessation,” “smoking cessation therapy,” “smoking cessation interventions,” “smoking cessation pregnancy,” “smoking cessation weight,” “smoking cessation side effects,” and “smoking cessation exercise.” “Tobacco Dependence”

Current Search Term:

“Smoking Cessation”

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Smoking Cessation Intervention

Condition:   Smoking Cessation
Interventions:   Behavioral: Spotlight on Smoke-Free Living: Mindsets and Decisions;   Drug: Transdermal Nicotine Patch
Sponsors:   University of Florida;   National Institute on Drug Abuse (NIDA)
Recruiting - verified March 2017

Smoking Cessation Intervention During Low Dose CT (LDCT) Screening for Lung Cancer

Condition:   Smoking Cessation
Interventions:   Behavioral: Questionnaires;   Procedure: Low Dose Computed Tomography Scan;   Other: Shared Decision Making + Video;   Behavioral: Cessation Counseling;   Behavioral: Quitline;   Behavioral: Pharmacotherapy Discussion;   Drug: Nicotine Patch;   Drug: Anti-Smoking Drug;   Behavioral: Tobacco Treatment Program;   Other: Carbon Monoxide (CO) Level Test
Sponsors:   M.D. Anderson Cancer Center;   National Cancer Institute (NCI)
Not yet recruiting - verified May 2017

Cytisine Versus Varenicline for Smoking Cessation

Condition:   Smoking Cessation
Interventions:   Drug: Cytisine;   Behavioral: Behavioural support;   Drug: Varenicline
Sponsors:   University of Auckland, New Zealand;   Lakes District Health Board;   Brunel University
Not yet recruiting - verified May 2017

Clinical Trial of an Automated Smartphone Based Smoking Cessation Treatment

Condition:   Smoking Cessation
Interventions:   Behavioral: Treatment as Usual;   Behavioral: QuitGuide;   Behavioral: Smart-T
Sponsor:   University of Oklahoma
Not yet recruiting - verified May 2017

Short-bout Handgrip Exercise for Smoking Cessation

Condition:   Smoking Cessation
Interventions:   Behavioral: Video about exercise;   Behavioral: App about exercise;   Behavioral: Leaflet about exercise;   Behavioral: Video about diet;   Behavioral: App about diet;   Behavioral: Leaflet about diet
Sponsors:   The University of Hong Kong;   Tung Wah Group of Hospitals
Recruiting - verified May 2017

Enhancing Relapse Prevention for Smoking Cessation With Repetitive Transcranial Magnetic Stimulation

Condition:   Smoking Cessation
Interventions:   Device: rTMS Active 20Hz;   Device: rTMS Sham
Sponsors:   The City College of New York;   National Cancer Institute (NCI);   Virginia Tech Carilion Research Institute
Completed - verified June 2016

Trial of Treatment Protocol for Smoking Cessation

Condition:   Smoking Cessation
Interventions:   Other: Traditional & Complementary Medicine treatment;   Other: NRT, counselling
Sponsor:   Daejeon University
Recruiting - verified February 2017

Small Financial Incentives to Promote Smoking Cessation

Condition:   Smoking Cessation
Interventions:   Behavioral: Standard Care + Financial Incentives;   Other: Standard Care
Sponsors:   University of Oklahoma;   National Cancer Institute (NCI);   The University of Texas Health Science Center, Houston;   William Marsh Rice University
Recruiting - verified March 2017

Worksite Phone Counseling for Smoking Cessation

Condition:   Smoking Cessation
Interventions:   Behavioral: Nondirective smoking cessation coaching;   Behavioral: Directive smoking cessation coaching
Sponsor:   Washington University School of Medicine
Completed - verified October 2016

Evaluating the Efficacy of E-Cigarette Use for Smoking Cessation (E3) Trial

Condition:   Smoking Cessation
Interventions:   Other: Nicotine E-Cigarette;   Other: Non-Nicotine E-Cigarette;   Behavioral: Counseling
Sponsor:   McGill University
Recruiting - verified December 2016

Patient Navigation and Financial Incentives to Promote Smoking Cessation

Condition:   Smoking Cessation
Interventions:   Behavioral: Intervention;   Other: Enhanced Traditional Care control
Sponsor:   Boston Medical Center
Active, not recruiting - verified March 2017

Genetically Informed Smoking Cessation Trial

Condition:   Smoking Cessation
Interventions:   Drug: Combination NRT (Nicotine patch, Nicotine lozenge);   Drug: Varenicline;   Drug: Placebo
Sponsors:   Washington University School of Medicine;   National Institutes of Health (NIH);   National Institute on Drug Abuse (NIDA)
Recruiting - verified September 2016

Novel Smoking Cessation Drug for Schizophrenia

Condition:   Smoking Cessation
Interventions:   Drug: Active JNJ Drug;   Drug: Placebo Pill
Sponsors:   K.N. Roy Chengappa;   University of Pittsburgh;   National Institutes of Health (NIH);   Virginia Commonwealth University
Completed - verified March 2017

Evaluation of Deep Transcranial Magnetic Stimulation (DTMS) With the H-ADD Coil as an Aid to Smoking Cessation.

Condition:   Smoking Cessation
Interventions:   Device: Sham Treatment;   Device: Active dTMS Treatment
Sponsor:   Brainsway
Recruiting - verified February 2017

Smoking Cessation After Hospitalization for a Cardiopulmonary Illness

Condition:   Smoking Cessation
Interventions:   Behavioral: hypnotherapy;   Drug: Nicotine
Sponsor:   North Shore Medical Center
Completed - verified May 2017

Study To Evaluate Cardiac Assessments Following Different Treatments Of Smoking Cessation Medications In Subjects With And Without Psychiatric Disorders.

Condition:   Smoking Cessation
Interventions:   Drug: placebo;   Drug: varenicline tartrate;   Drug: bupropion hydrochloride;   Drug: Nicotine Replacement Therapy Patch
Sponsor:   Pfizer
Completed - verified October 2016

Smoking Cessation With the Ottawa Model and SmartCard in Out-patient Respirology Clinic Setting

Condition:   Smoking Cessation
Interventions:   Behavioral: Ottawa Model with SmartCard;   Behavioral: Usual care
Sponsors:   Ottawa Hospital Research Institute;   Ottawa Heart Institute Research Corporation
Completed - verified November 2013

Smoking Cessation Study In Healthy Adolescent Smokers

Condition:   Smoking Cessation
Interventions:   Drug: Varenicline 1mg BID;   Drug: Varenicline 0.5mg BID;   Drug: Placebo
Sponsor:   Pfizer
Active, not recruiting - verified April 2017

Social Determinants and Smoking Cessation

Condition:   Smoking Cessation
Interventions:   Behavioral: Questionnaires;   Drug: Nicotine Patch Therapy;   Behavioral: Counseling Sessions
Sponsors:   M.D. Anderson Cancer Center;   Cancer Prevention Research Institute of Texas;   National Institute on Minority Health and Health Disparities (NIMHD)
Completed - verified October 2016

Smoking Cessation in Hospitalized Smokers

Condition:   Smoking Cessation
Interventions:   Drug: Nicotine Patches;   Behavioral: Telephone Counseling;   Behavioral: Brief Hospital Counseling
Sponsors:   University of California, San Diego;   National Cancer Institute (NCI)
Completed - verified October 2016

Smoking Cessation With the Nicotine Patch: A Pilot Study of Patch Messaging

Condition:   Smoking Cessation
Interventions:   Behavioral: Telephone Counseling;   Drug: Nicotine Patches
Sponsor:   University of California, San Diego
Completed - verified October 2016

Smoking Cessation for American Indians

Condition:   Smoking Cessation
Interventions:   Behavioral: All Nations Breath of Life (ANBL);   Behavioral: Nontailored program (NT);   Drug: Pharmacotherapy
Sponsors:   Won Choi, PhD, MPH;   National Cancer Institute (NCI)
Completed - verified March 2017

Determinants of Smoking Cessation Among Latinos

Condition:   Smoking Cessation
Interventions:   Drug: Nicotine Replacement Therapy (NRT);   Behavioral: Questionnaire;   Behavioral: Counseling;   Behavioral: Self-Help Materials
Sponsors:   M.D. Anderson Cancer Center;   National Institute on Minority Health and Health Disparities (NIMHD);   Department of Health and Human Services;   National Institutes of Health (NIH)
Completed - verified September 2016

An Integrated Approach to Smoking Cessation in Severe Mental Illness (SMI)

Condition:   Smoking Cessation
Intervention:   Behavioral: BTSCS
Sponsors:   University of Maryland;   National Institute of Mental Health (NIMH)
Completed - verified March 2017

Smoking Cessation Aid for Young Smokers

Condition:   Smoking Cessation
Intervention:   Behavioral: Smoking cessation
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Completed - verified December 14, 2006

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