Smoking Cessation

About Smoking Cessation Clinical Trials (Click to Open)

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Smoking CessationGeneral Purpose

Smoking is the single-most preventable cause of death. Smoking has negative effects on nearly every part of the body, and second-hand smoke (or environmental tobacco smoke) can also cause negative health effects to individuals who do not smoke.

Although smoking rates have declined over the past few decades, it is still a widespread behavior and costs the American economy tens of billions of dollars in health-related costs each year.

As such, there is an abundant amount of research currently ongoing to investigate new methods of helping individuals stop smoking, as well as to better understand the ways in which nicotine (the addictive component of cigarettes and other tobacco products) exerts its effects on the body and leads to addiction.  

What Will Smoking Cessation Clinical Trials Be Like?

When participating in clinical trials for smoking cessation, a few common tests and procedures may be involved; however, the ultimate design of the particular study will determine which specific procedures you will undergo.

For example, studies designed to test a new drug that can help reduce the urge to smoke may involve repeated blood tests to measure both drug and nicotine levels in the blood. Urine tests may also be required in order to evaluate the amount and type of smoking-related chemicals in the urine.

Some studies may involve constant daily or weekly interaction with a “coach” who provides emotional support to the study participant in an effort to aid in the process of smoking cessation.

Other studies may require that you maintain a written or electronic diary of thoughts, feelings, how much you smoke, and nicotine-withdrawal symptoms. Some studies may require repeated physical fitness testing, or heart/lung function testing over a period of months or years in order to see how physical health improves following smoking cessation.

Typical Clinical Trials for Smoking Cessation Protocol:

There is a broad range of possible trials related to smoking cessation. Below are a few Smoking Cessation clinical trialsexamples of possible types of studies:

  • A trial to determine if a new antidepressant medication is more effective than current treatments at helping smokers quit.
  • A study designed to determine if increased physical activity improves cessation rates among smokers engaged in smoking cessation therapy.
  • A trial to investigate new therapies to help alleviate the symptoms associated with nicotine withdrawal during the process of smoking cessation.
  • A study to determine if certain genetic factors influence an individual’s ability to successfully quit smoking.
  • A study designed to evaluate heart function after taking medication to assist with smoking cessation.
  • A study to determine the effectiveness of new nicotine replacement therapies (i.e., skin patches or gum) in helping smokers to quit.

Suggested Search Terms:

“Smoking Cessation,” “smoking cessation therapy,” “smoking cessation interventions,” “smoking cessation pregnancy,” “smoking cessation weight,” “smoking cessation side effects,” and “smoking cessation exercise.” “Tobacco Dependence”

Current Search Term:

“Smoking Cessation”

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A Video-led Smoking Cessation Intervention in Helping Male Smokers Who is Planning to Have A Baby to Quit


Condition:   Smoking Cessation
Interventions:   Combination Product: Video+telephone counselling+pamphlet;   Combination Product: telephone counselling+pamphlet;   Other: pamphlet
Sponsor:   The University of Hong Kong
Recruiting


Smoking Cessation Intervention


Condition:   Smoking Cessation
Interventions:   Behavioral: Spotlight on Smoke-Free Living: Mindsets and Decisions;   Drug: Transdermal Nicotine Patch
Sponsors:   University of Florida;   National Institute on Drug Abuse (NIDA)
Recruiting


Smoking Cessation Intervention During Low Dose CT (LDCT) Screening for Lung Cancer


Condition:   Smoking Cessation
Interventions:   Behavioral: Questionnaires;   Procedure: Low Dose Computed Tomography Scan;   Other: Shared Decision Making + Video;   Behavioral: Cessation Counseling;   Behavioral: Quitline;   Behavioral: Pharmacotherapy Discussion;   Drug: Nicotine Patch;   Drug: Anti-Smoking Drug;   Behavioral: Tobacco Treatment Program;   Other: Carbon Monoxide (CO) Level Test
Sponsors:   M.D. Anderson Cancer Center;   National Cancer Institute (NCI)
Recruiting


Cytisine Versus Varenicline for Smoking Cessation


Condition:   Smoking Cessation
Interventions:   Drug: Cytisine;   Behavioral: Behavioural support;   Drug: Varenicline
Sponsors:   University of Auckland, New Zealand;   Lakes District Health Board;   Brunel University
Recruiting


Clinical Trial of an Automated Smartphone Based Smoking Cessation Treatment


Condition:   Smoking Cessation
Interventions:   Behavioral: Treatment as Usual;   Behavioral: QuitGuide;   Behavioral: Smart-T
Sponsor:   University of Oklahoma
Recruiting


Facilitating Smoking Cessation With Reduced Nicotine Cigarettes


Condition:   Smoking Cessation
Interventions:   Drug: Very Low Nicotine Content (VLNC) Cigarettes;   Behavioral: One on One Counseling
Sponsors:   H. Lee Moffitt Cancer Center and Research Institute;   James and Esther King Biomedical Research Program
Recruiting


Trial of Treatment Protocol for Smoking Cessation


Condition:   Smoking Cessation
Interventions:   Other: Traditional & Complementary Medicine treatment;   Other: NRT, counselling
Sponsor:   Daejeon University
Recruiting


The Efficacy of Acetium Lozenges in Intervention for Smoking Cessation


Condition:   Smoking Cessation
Interventions:   Drug: Acetium Lozenge;   Drug: Placebo
Sponsor:   Biohit Oyj
Completed


Worksite Phone Counseling for Smoking Cessation


Condition:   Smoking Cessation
Interventions:   Behavioral: Nondirective smoking cessation coaching;   Behavioral: Directive smoking cessation coaching
Sponsor:   Washington University School of Medicine
Completed


Evaluating the Efficacy of E-Cigarette Use for Smoking Cessation (E3) Trial


Condition:   Smoking Cessation
Interventions:   Other: Nicotine E-Cigarette;   Other: Non-Nicotine E-Cigarette;   Behavioral: Counseling
Sponsor:   McGill University
Recruiting


Patient Navigation and Financial Incentives to Promote Smoking Cessation


Condition:   Smoking Cessation
Interventions:   Behavioral: Intervention;   Other: Enhanced Traditional Care control
Sponsors:   Boston Medical Center;   American Cancer Society, Inc.
Completed


Novel Smoking Cessation Drug for Schizophrenia


Condition:   Smoking Cessation
Interventions:   Drug: Active JNJ Drug;   Drug: Placebo Pill
Sponsors:   K.N. Roy Chengappa;   University of Pittsburgh;   National Institutes of Health (NIH);   Virginia Commonwealth University
Completed


Evaluation of Deep Transcranial Magnetic Stimulation (DTMS) With the H-ADD Coil as an Aid to Smoking Cessation.


Condition:   Smoking Cessation
Interventions:   Device: Sham Treatment;   Device: Active dTMS Treatment
Sponsor:   Brainsway
Recruiting


Assessing the Effectiveness of a Pharmacist-delivered Smoking Cessation Program in the State of Qatar


Condition:   Smoking Cessation
Interventions:   Behavioral: Pharmacist delivered smoking cessation program;   Other: Control arm (i.e: regular care)
Sponsors:   Qatar University;   Hamad Medical Corporation
Unknown status


Smoking Cessation After Hospitalization for a Cardiopulmonary Illness


Condition:   Smoking Cessation
Interventions:   Behavioral: hypnotherapy;   Drug: Nicotine
Sponsor:   North Shore Medical Center
Completed


Study To Evaluate Cardiac Assessments Following Different Treatments Of Smoking Cessation Medications In Subjects With And Without Psychiatric Disorders.


Condition:   Smoking Cessation
Interventions:   Drug: placebo;   Drug: varenicline tartrate;   Drug: bupropion hydrochloride;   Drug: Nicotine Replacement Therapy Patch
Sponsor:   Pfizer
Completed


Smoking Cessation With the Ottawa Model and SmartCard in Out-patient Respirology Clinic Setting


Condition:   Smoking Cessation
Interventions:   Behavioral: Ottawa Model with SmartCard;   Behavioral: Usual care
Sponsors:   Ottawa Hospital Research Institute;   Ottawa Heart Institute Research Corporation
Completed


Extended Treatment for Smoking Cessation


Condition:   Smoking Cessation
Interventions:   Drug: Bupropion;   Drug: Nicotine patch;   Drug: Varenicline
Sponsors:   Stanford University;   National Institute on Drug Abuse (NIDA)
Completed


Smoking Cessation Study In Healthy Adolescent Smokers


Condition:   Smoking Cessation
Interventions:   Drug: Varenicline 1mg BID;   Drug: Varenicline 0.5mg BID;   Drug: Placebo
Sponsor:   Pfizer
Active, not recruiting


Smoking Cessation in Hospitalized Smokers


Condition:   Smoking Cessation
Interventions:   Drug: Nicotine Patches;   Behavioral: Telephone Counseling;   Behavioral: Brief Hospital Counseling
Sponsors:   University of California, San Diego;   National Cancer Institute (NCI)
Completed


Smoking Cessation With the Nicotine Patch: A Pilot Study of Patch Messaging


Condition:   Smoking Cessation
Interventions:   Behavioral: Telephone Counseling;   Drug: Nicotine Patches
Sponsor:   University of California, San Diego
Completed


An Alternative Dosing Schedule of Varenicline for Smoking Cessation


Condition:   Smoking Cessation
Interventions:   Drug: varenicline;   Drug: placebo
Sponsors:   Roswell Park Cancer Institute;   Pfizer
Completed


An Integrated Approach to Smoking Cessation in Severe Mental Illness (SMI)


Condition:   Smoking Cessation
Intervention:   Behavioral: BTSCS
Sponsors:   University of Maryland;   National Institute of Mental Health (NIMH)
Completed


Increasing Physical Activity as Part of a Smoking Cessation Program


Condition:   Smoking Cessation
Interventions:   Behavioral: Smoking Cessation Behavioral Program;   Drug: Nicotine Patch;   Behavioral: Physical Activity
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed


Smoking Cessation Aid for Young Smokers


Condition:   Smoking Cessation
Intervention:   Behavioral: Smoking cessation
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Completed

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