About Pneumonia Clinical Trials (Click to Open)

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Pneumonia Clinical TrialsGeneral Purpose

The lung inflammation that characterizes pneumonia is typically caused by a bacterial, viral, or fungal infection.

Furthermore, specific groups of individuals are more likely to develop pneumonia than others, including individuals over age 65 and those under the age of 2, as well as those who have pre-existing health problems, including heart failure, diabetes, and COPD.

In light of these known facts about pneumonia, research seeks to improve methods of preventing, diagnosing, and treating pneumonia.

What Will Pneumonia Clinical Trials Be Like?

When participating in a clinical trial for pneumonia, a few common tests and procedures may be involved; however, the ultimate design of the particular study will determine which specific procedures you will undergo.

On a basic level, you may be asked to provide a detailed history describing your symptoms, their duration, severity, and current or recent exposures (i.e., to people, animals, and travel). Your lungs will likely be examined by the study doctor through the use of a stethoscope.

In addition, you may have a chest x-ray to better visualize the infection in your lungs, or to monitor the progress of a specific treatment you are receiving for your pneumonia. Blood tests might also be involved to monitor signs of infection or your response to medications.

You may also be asked to provide a sputum/spit sample, undergo a CT scan (which is an x-ray like procedure that provides detailed images of areas inside your body), or undergo a procedure known as thoracentisis (the removal of fluid from the space between the outside lining of your lungs and the chest wall).

Your pulse and the amount of oxygen in your blood may also be measured, and you may be asked to undergo a bronchoscopy (a procedure in which your doctor inserts a flexible tube with a light on the end through your nose or mouth and into your airways).

Typical Pneumonia Clinical Trial Protocol:

Examples of pneumonia-related clinical trials might include the following:Pneumonia Clinical Trials

  • A study to determine if proactive treatment with antibiotics or antiviral medications in hospitalized patients with heart disease helps to prevent the development of pneumonia.
  • A study to determine the risk of pneumonia among individuals who smoke.
  • A study to determine the effectiveness of a newly-developed antibacterial or antiviral medication in treating pneumonia.
  • A study to determine the accuracy of a newly-developed diagnostic tool or imaging procedure to correctly diagnose the presence of pneumonia.
  • A study designed to determine the risk of developing pneumonia among individuals who received different types of breathing tubes during surgical procedures.

Suggested Search Terms:

“pneumonia children,” “pneumonia treatment,” “pneumonia bacteria,” “pneumonia virus,” “pneumonia COPD,” and “pneumonia surgery.”

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Anaerobic Antibiotic Usage for Pneumonia in the Medical Intensive Care Unit

Condition:   Pneumonia
Intervention:   Drug: Antibiotics
Sponsor:   Henry Ford Health System
Completed - verified February 2017

Diagnostic Use of Lung Ultrasound for Suspected Pneumonia in Nepal

Condition:   Pneumonia
Intervention:   Device: Lung Ultrasound
Sponsors:   Patan Academy of Health Sciences;   Vanderbilt University;   Indiana University School of Medicine
Not yet recruiting - verified October 2016

Innovative Treatments in Pneumonia (ITIP) 3

Condition:   Pneumonia
Interventions:   Drug: oral amoxicillin or parenteral ampicillin/ penicillin and gentamicin;   Drug: parenteral ampicillin/ penicillin;   Drug: gentamicin
Sponsors:   Save the Children;   University of Washington;   University of North Carolina, Project Lilongwe Medical Relief Trust Fund;   Kamuzu Central Hospital;   College of Medicine at the University of Malawi
Recruiting - verified November 2016

Screening for Pneumonia: A Comparison of Ultra Low Dose Chest CT [ULD-CT] and Conventional Chest Radiography [CXR]

Condition:   Pneumonia
Interventions:   Radiation: ULD-CT;   Radiation: CXR
Sponsor:   Maastricht University Medical Center
Recruiting - verified December 2016

Trial to Evaluate Beta-Lactam Antimicrobial Therapy of Community Acquired Pneumonia in Children

Condition:   Pneumonia
Interventions:   Drug: Amoxicillin;   Drug: Amoxicillin-clavulanate;   Drug: Cefdinir;   Other: Placebo
Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified April 5, 2017

Community Case Management of Chest Indrawing Pneumonia

Condition:   Pneumonia
Intervention:   Drug: Oral amoxicillin for CI pneumonia
Sponsors:   Malaria Consortium;   World Health Organization
Recruiting - verified October 2016

IMPROVinG Outcomes in Community Acquired Pneumonia

Condition:   Pneumonia
Interventions:   Other: New model of service delivery;   Other: Current practice
Sponsors:   Western Health, Australia;   University of Melbourne;   Monash University;   La Trobe University
Recruiting - verified April 2017

International Study on NoSocomial Pneumonia in Intensive CaRE (PneumoINSPIRE)

Condition:   Nosocomial Pneumonia
Intervention:   Other: No intervention
Sponsors:   The University of Queensland;   European Society of Intensive Care Medicine
Recruiting - verified June 2016

Hospitalised Pneumonia With Extended Treatment (HOPE) Study

Condition:   Pneumonia
Interventions:   Drug: Amoxicillin-clavulanic Acid;   Drug: Placebo (for Amoxicillin-clavulanic Acid)
Sponsors:   Menzies School of Health Research;   Griffith University;   Sarawak General Hospital;   University of Malaya;   The University of Queensland;   Queensland University of Technology;   Nanyang Technological University
Recruiting - verified October 2016

PICR-b Nasopharyngeal S. Pneumoniae and Nasal S. Aureus Carriage Study

Condition:   Streptococcus Pneumoniae
Intervention:   Biological: PCV
Sponsors:   Sheba Medical Center;   Palestinian-Israeli Collaborative Research (PICR);   United States Agency for International Development (USAID);   The Israeli National Institute for Health Policy Research;   Maccabi Healthcare Services Research Fund
Recruiting - verified February 2017

A Clinical Cohort Study of Pneumonia in Respiratory Intensive Care Unit

Condition:   Pneumonia
Intervention:   Other: pneumonia
Sponsor:   Beijing Chao Yang Hospital
Recruiting - verified June 2016

Measuring Auto-fluorescence of White Corpuscles for the Early Diagnosis and the Monitoring of Pneumonia in ICU

Condition:   Pneumonia
Intervention:   Other: Autofluorescence of white corpuscle
Sponsor:   Nantes University Hospital
Recruiting - verified July 2016

Study to Compare Delafloxacin to Moxifloxacin for the Treatment of Adults With Community-acquired Bacterial Pneumonia

Condition:   Community Acquired Bacterial Pneumonia
Interventions:   Drug: Delafloxacin;   Drug: Moxifloxacin;   Drug: Linezolid
Sponsor:   Melinta Therapeutics, Inc.
Recruiting - verified May 2017

Physiotherapy in Patients Hospitalized Due to Pneumonia.

Condition:   Pneumonia
Interventions:   Drug: cephalosporin with or without erythromycin;   Other: Physiotherapy program
Sponsor:   Universidad de Granada
Recruiting - verified November 2016

Community-Acquired Pneumonia : Evaluation of Corticosteroids

Condition:   Community Acquired Pneumonia
Interventions:   Drug: Hydrocortisone;   Drug: Placebo
Sponsor:   University Hospital, Tours
Recruiting - verified May 2017

Trial on the Ideal Duration of Oral Antibiotics in Children With Pneumonia

Condition:   Pneumonia
Interventions:   Drug: Amoxicillin-Potassium Clavulanate Combination;   Drug: Placebo
Sponsors:   University of Malaya;   Menzies School of Health Research
Active, not recruiting - verified December 2016

Vitamin-D Supplementation: Impact on Severe Pneumonia Among Under-five Children

Condition:   Pneumonia
Interventions:   Drug: Vitamin D3;   Drug: Placebo
Sponsors:   International Centre for Diarrhoeal Disease Research, Bangladesh;   Centers for Disease Control and Prevention
Recruiting - verified August 2016

Tedizolid Phosphate (TR-701 FA) vs Linezolid for the Treatment of Nosocomial Pneumonia (MK-1986-002)

Condition:   Pneumonia
Interventions:   Drug: Tedizolid phosphate IV;   Drug: Linezolid
Sponsor:   Cubist Pharmaceuticals LLC
Recruiting - verified May 2017

Bacterial Pneumonia Score (BPS) Guided Antibiotic Use in Children With Pneumonia and Pneumococcal Vaccine

Condition:   Community Acquired Pneumonia
Interventions:   Behavioral: BPS;   Behavioral: Guideline
Sponsor:   Hospital General de Niños Pedro de Elizalde
Completed - verified January 2017

Santeon-CAP; Dexamethasone in Community-acquired Pneumonia

Condition:   Community-acquired Pneumonia
Interventions:   Drug: Dexamethasone;   Drug: Placebo
Sponsors:   St. Antonius Hospital;   Canisius-Wilhelmina Hospital;   Onze Lieve Vrouw Hospital;   Catharina Ziekenhuis Eindhoven
Recruiting - verified October 2016

Duration of Antimicrobial Therapy for Paediatric Pneumonia

Condition:   Pneumonia
Intervention:   Drug: amoxicillin
Sponsor:   Hamilton Health Sciences Corporation
Completed - verified February 2017

Safety, Pharmacokinetics and Efficacy of KBSA301 in Severe Pneumonia (S. Aureus)

Condition:   Pneumonia Due to Staphylococcus Aureus
Interventions:   Drug: KBSA301;   Drug: Placebo
Sponsor:   Aridis Pharmaceuticals, Inc.
Completed - verified September 2016

Efficacy and Safety Study of Oral CEM-101 Compared to Oral Levofloxacin in Treatment of Patients With Community-Acquired Bacterial Pneumonia

Condition:   Community-Acquired Bacterial Pneumonia
Interventions:   Drug: Levofloxacin;   Drug: CEM-101
Sponsor:   Cempra Inc
Completed - verified March 2017

Bacterial Pneumonia Score (BPS) Guided Antibiotic Use in Children With Community Acquired Pneumonia

Condition:   Pneumonia
Interventions:   Behavioral: Strategy based on BPS guided antibiotic use;   Behavioral: Enforced Guidelines
Sponsor:   Hospital General de Niños Pedro de Elizalde
Completed - verified June 2013

CHIZAP: Community- and Health Facility-Based Intervention With Zinc as Adjuvant Therapy for Childhood Pneumonia

Condition:   Pneumonia
Intervention:   Drug: Zinc
Sponsors:   Centre For International Health;   Tribhuvan University, Nepal;   Statens Serum Institut;   All India Institute of Medical Sciences, New Delhi;   IRD, Epidemiologie et Prevention, Montpelier, France;   Society for Applied Studies
Completed - verified January 2017

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