A Trial on the Effects of Bronchoscopic Lung Volume Reduction in Severe Emphysema.

Condition:   Emphysema
Interventions:   Behavioral: Pulmonary rehabilitation;   Device: EBV treatment
Sponsors:   University Medical Center Groningen;   Maastricht University Medical Center
Not yet recruiting

Smoking Cessation and Functional CT Assessment

Condition:   Emphysema
Interventions:   Drug: Sildenafil 20 MG;   Drug: Placebo Oral Tablet
Sponsors:   Eric A. Hoffman;   National Institutes of Health (NIH);   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Study of PneumRx Endobronchial Coil System in Treatment of Subjects With Severe Emphysema

Condition:   Emphysema
Intervention:   Device: Endobronchial Coils
Sponsor:   PneumRx, Inc.
Not yet recruiting

Post-Market BTVA Registry

Condition:   Emphysema or COPD
Intervention:   Device: Bronchoscopic thermal vapor ablation
Sponsors:   Uptake Medical Technology, Inc.;   acromion GmbH
Not yet recruiting

Site and Mechanism(s) of Expiratory Airflow Limitation in COPD, Emphysema and Asthma-COPD Overlap

Conditions:   COPD, Emphysema, Asthma COPD Overlap;   Emphysema
Intervention:   Other: As above: diagnosis: COPD, Emphysema, Asthma-COPD Overlap
Sponsor:   Gelb, Arthur F., M.D.
Recruiting

Belimumab Treatment of Emphysema Patients With Anti-GRP78 Autoantibodies

Conditions:   Chronic Obstructive Pulmonary Disease;   Emphysema
Interventions:   Biological: Belimumab;   Drug: Placebo
Sponsors:   University of Alabama at Birmingham;   GlaxoSmithKline
Not yet recruiting

Chartis Collateral Ventilation Measurement: Conscious Sedation Versus General Anesthesia

Condition:   Emphysema or COPD
Intervention:   Other: Type of sedation used
Sponsor:   University Medical Center Groningen
Recruiting

Efficacy/Safety of HA Inhalation Solution for Hereditary Emphysema in Patients With Alpha-1 Antitrypsin Deficiency

Conditions:   Emphysema;   Alpha 1-Antitrypsin Deficiency
Interventions:   Drug: Hyaluronic Acid Inhalation Solution;   Drug: Placebo Inhalation Solution
Sponsor:   Gerard Turino
Recruiting

LVR in Severe Emphysema Using Bronchoscopic Autologous Blood Instillation in Combination With Intra-bronchial Valves

Conditions:   Chronic Obstructive Pulmonary Disease;   Emphysema
Intervention:   Device: Intra-bronchial valve and blood
Sponsor:   Royal Brompton & Harefield NHS Foundation Trust
Recruiting

REACH SVS Control Patient Cross-Over Study

Condition:   Emphysema
Intervention:   Device: Spiration Valve System
Sponsor:   Spiration, Inc.
Active, not recruiting

Clinical Study to Evaluate the Exercise Capacity in Patients With Severe Emphysema Treated With Coils

Condition:   Pulmonary Emphysema
Interventions:   Procedure: 10 coils in upper lobes;   Procedure: 15 coils in upper and lower lobes;   Procedure: cycloergometry
Sponsor:   Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Recruiting

Losartan Effects on Emphysema Progression

Condition:   Emphysema
Interventions:   Drug: Losartan;   Drug: Placebo
Sponsors:   Johns Hopkins University;   University of Pittsburgh
Recruiting

Functional CT Assessment of Pulmonary Arterial Dysfunction in Smoking Associated Emphysema

Condition:   Emphysema
Intervention:   Drug: Sildenafil
Sponsors:   Eric A. Hoffman;   National Institutes of Health (NIH);   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

A Prospective Multicenter Clinical Study to Evaluate the Safety and Effectiveness of the OL-BF-001 for Severe Emphysema

Condition:   Emphysema
Intervention:   Device: OL-BF-001
Sponsor:   Olympus Corporation
Recruiting

A Safety and Feasibility Study of Re-treating Patients With Severe Emphysema With the RePneu LVRC System.

Conditions:   COPD;   Emphysema
Intervention:   Device: Bronchoscopic lung volume reduction
Sponsor:   University Medical Center Groningen
Completed

Prostaglandin Inhibition for Emphysema

Condition:   Emphysema
Interventions:   Drug: 600 mg ibuprofen three times daily for 48 weeks;   Other: Placebo three times daily
Sponsors:   University of Nebraska;   National Jewish Health;   Temple University;   University of California, Los Angeles;   University of Alabama at Birmingham
Active, not recruiting

Efficacy and Safety of Alpha1-Proteinase Inhibitor (Human), Modified Process (Alpha-1 MP) in Subjects With Pulmonary Emphysema Due to Alpha1 Antitrypsin Deficiency (AATD)

Condition:   Pulmonary Emphysema in Alpha-1 PI Deficiency
Interventions:   Biological: Alpha-1 MP;   Other: 0.9% Sodium Chloride for Injection, USP
Sponsor:   Grifols Therapeutics LLC
Recruiting

The Effect and Mechanism of Bronchoscopic Lung Volume Reduction by Endobronchial Valve in Korean Emphysema Patients

Condition:   Pulmonary Emphysema
Intervention:   Device: Endobronchial valve
Sponsor:   Asan Medical Center
Completed

Clinical Study of the Efficacy and Safety of the Application of Allogeneic Mesenchymal (Stromal) Cells of Bone Marrow, Cultured Under the Hypoxia in the Treatment of Patients With Severe Pulmonary Emphysema

Condition:   Pulmonary Emphysema
Interventions:   Biological: Mesenchymal stem cells;   Other: Reference therapy: 400 mL of 0.9% NaCl solution
Sponsor:   Federal Research Clinical Center of Federal Medical & Biological Agency, Russia
Withdrawn

Evaluation of the Spiration® Valve System for Emphysema to Improve Lung Function

Condition:   Emphysema
Interventions:   Device: Spiration Valve System;   Other: Medical Management
Sponsor:   Spiration, Inc.
Active, not recruiting

Pulmonx Endobronchial Valves Used in Treatment of Emphysema (LIBERATE Study)

Condition:   Emphysema
Interventions:   Device: EBV;   Other: Optimal Medical Management
Sponsor:   Pulmonx, Inc.
Active, not recruiting

Lung Volume Reduction Coil Treatment in Patients With Emphysema (RENEW) Study

Condition:   Emphysema
Intervention:   Device: RePneu Lung Volume Reduction Coil System
Sponsor:   PneumRx, Inc.
Active, not recruiting

Long Term Follow up Investigation of Endobronchial Valves in Emphysema

Condition:   Pulmonary Emphysema
Intervention:   Device: Zephyr Endobronchial Valve (EBV)
Sponsor:   Pulmonx International Sàrl
Terminated

A Study of the Use of Chartis System to Optimize Subject Selection for Endobronchial Lung Volume Reduction (ELVR)

Condition:   Emphysema
Interventions:   Device: Chartis System;   Device: Endobronchial Valve (EBV) Treatment
Sponsor:   Pulmonx, Inc.
Completed

Clinical Trial to Evaluate the Safety and Effectiveness of the IBV® Valve System for the Treatment of Severe Emphysema

Conditions:   Emphysema;   COPD
Intervention:   Device: IBV® Valve System
Sponsor:   Spiration, Inc.
Completed