Efficacy/Safety of HA Inhalation Solution for Hereditary Emphysema in Patients With A1Antitrypsin Deficiency

Condition:   Emphysema
Interventions:   Drug: Hyaluronic Acid Inhalation Solution;   Drug: Placebo Inhalation Solution
Sponsor:   Gerard Turino
Recruiting - verified April 2017

LVR in Severe Emphysema Using Bronchoscopic Autologous Blood Instillation in Combination With Intra-bronchial Valves

Conditions:   Chronic Obstructive Pulmonary Disease;   Emphysema
Intervention:   Device: Intra-bronchial valve and blood
Sponsor:   Royal Brompton & Harefield NHS Foundation Trust
Not yet recruiting - verified January 2017

Spiration Valve System 9 mm European Post Market Evaluation Study

Condition:   Emphysema
Intervention:   Device: Implementation of 9 mm intrabronchial valves
Sponsors:   Heidelberg University;   Lung Clinic Hemer;   Asklepios Kliniken Hamburg GmbH;   Otto Wagner Hospital
Recruiting - verified December 2016

REACH SVS Control Patient Cross-Over Study

Condition:   Emphysema
Intervention:   Device: Spiration Valve System
Sponsor:   Spiration, Inc.
Active, not recruiting - verified September 2016

Clinical Study to Evaluate the Exercise Capacity in Patients With Severe Emphysema Treated With Coils

Condition:   Pulmonary Emphysema
Interventions:   Procedure: 10 coils in upper lobes;   Procedure: 15 coils in upper and lower lobes;   Procedure: cycloergometry
Sponsor:   Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Not yet recruiting - verified August 2016

Hyperinflation Assessment After Treatment by Lung Volume Reduction Coil

Condition:   Emphysema
Interventions:   Procedure: Bronchoscopy;   Device: Lung Volume Reduction Coil (HEAT-LVRC)
Sponsor:   University Hospital, Toulouse
Not yet recruiting - verified July 2016

Endobronchial Valve in Patients With Heterogeneous Emphysema

Conditions:   Chronic Obstructive Pulmonary Disease;   Emphysema
Intervention:   Device: Zephyr endobronchial valve placement
Sponsor:   Chinese PLA General Hospital
Active, not recruiting - verified June 2016

A Clinical Evaluation of Baofeikang Granule in Combined Pulmonary Fibrosis and Emphysema Treatment

Condition:   Combined Pulmonary Fibrosis and Emphysema
Interventions:   Drug: Baofeikang Granule;   Drug: Placebo
Sponsor:   Beijing Municipal Science & Technology Commission
Recruiting - verified October 2016

Long Term Safety of Alpha1-Proteinase Inhibitor in Subjects With Alpha1 Antitrypsin Deficiency

Condition:   Pulmonary Emphysema in Alpha-1 Antitrypsin Deficiency
Intervention:   Biological: Alpha-1 MP
Sponsor:   Grifols Therapeutics Inc.
Enrolling by invitation - verified December 2016

Longitudinal Follow up to Assess Biomarkers Predictive of Emphysema Progression in Patients With COPD (Chronic Obstructive Pulmonary Disease)

Conditions:   Pulmonary Disease, Chronic Obstructive;   Pulmonary Emphysema
Sponsor:   Boehringer Ingelheim
Recruiting - verified May 2017

Losartan Effects on Emphysema Progression

Condition:   Emphysema
Interventions:   Drug: Losartan;   Drug: Placebo
Sponsors:   Johns Hopkins University;   University of Pittsburgh
Not yet recruiting - verified May 2017

Functional CT Assessment of Pulmonary Arterial Dysfunction in Smoking Associated Emphysema

Condition:   Emphysema
Interventions:   Drug: Tadalafil;   Drug: Sildenafil
Sponsors:   University of Iowa;   National Institutes of Health (NIH);   National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting - verified April 2017

In Vivo Endomicroscopic Description of Pulmonary Microcirculation in Systemic Sclerosis and Emphysema Patients

Conditions:   Pulmonary Disease;   Pulmonary Emphysema
Intervention:   Device: Bronchoscopy with in vivo confocal endomicroscopy
Sponsor:   University Hospital, Rouen
Recruiting - verified December 2016

A Prospective Multicenter Clinical Study to Evaluate the Safety and Effectiveness of the OL-BF-001 for Severe Emphysema

Condition:   Emphysema
Intervention:   Device: OL-BF-001
Sponsor:   Olympus Corporation
Recruiting - verified January 2017

To Improve Lung Function and Symptoms for Emphysema Patients Using Zephyr EBV

Conditions:   COPD;   Heterogeneous Emphysema
Intervention:   Device: ELVR (Endoscopic Lung Volume Reduction) with Zephyr valve
Sponsor:   Pulmonx, Inc.
Active, not recruiting - verified April 2017

Efficacy and Safety of Alpha1-Proteinase Inhibitor (Human), Modified Process (Alpha-1 MP) in Subjects With Pulmonary Emphysema Due to Alpha1 Antitrypsin Deficiency (AATD)

Condition:   Pulmonary Emphysema in Alpha-1 PI Deficiency
Interventions:   Biological: Alpha1-proteinase inhibitor (human), modified process (Alpha-1 MP);   Other: 0.9% Sodium Chloride for Injection, USP
Sponsor:   Grifols Therapeutics Inc.
Recruiting - verified December 2016

A Safety and Feasibility Study of Re-treating Patients With Severe Emphysema With the RePneu LVRC System.

Conditions:   COPD;   Emphysema
Intervention:   Device: Bronchoscopic lung volume reduction
Sponsor:   University Medical Center Groningen
Completed - verified September 2016

Evaluation of the Spiration® Valve System for Emphysema to Improve Lung Function

Condition:   Emphysema
Interventions:   Device: Spiration Valve System;   Other: Medical Management
Sponsor:   Spiration, Inc.
Active, not recruiting - verified May 2017

Pulmonx Endobronchial Valves Used in Treatment of Emphysema (LIBERATE Study)

Condition:   Emphysema
Interventions:   Device: EBV;   Other: Optimal Medical Management
Sponsor:   Pulmonx, Inc.
Active, not recruiting - verified September 2016

Long Term Follow up Investigation of Endobronchial Valves in Emphysema

Condition:   Pulmonary Emphysema
Intervention:   Device: Zephyr Endobronchial Valve (EBV)
Sponsor:   Pulmonx International Sàrl
Terminated - verified April 2017

International Study Evaluating the Safety and Efficacy of Inhaled, Human, Alpha-1 Antitrypsin (AAT) in Alpha-1 Antitrypsin Deficient Patients With Emphysema

Condition:   Emphysema
Interventions:   Biological: Kamada AAT for inhalation;   Other: Placebo
Sponsor:   Kamada, Ltd.
Completed - verified April 2016

A Study of the Use of Chartis System to Optimize Subject Selection for Endobronchial Lung Volume Reduction (ELVR)

Condition:   Emphysema
Interventions:   Device: Chartis System;   Device: Endobronchial Valve (EBV) Treatment
Sponsor:   Pulmonx, Inc.
Completed - verified April 2017

Extension Study of Zemaira® i.v. Administration in Subjects With Emphysema Due to alpha1-proteinase Inhibitor Deficiency.

Conditions:   Emphysema;   Alpha 1-proteinase Inhibitor Deficiency
Intervention:   Biological: Alpha1- proteinase inhibitor [human]
Sponsor:   CSL Behring
Completed - verified July 2016

Clinical Trial to Evaluate the Safety and Effectiveness of the IBV® Valve System for the Treatment of Severe Emphysema

Conditions:   Emphysema;   COPD
Intervention:   Device: IBV® Valve System
Sponsor:   Spiration, Inc.
Completed - verified April 2016

TESRA: (Treatment of Emphysema With a Gamma-Selective Retinoid Agonist)

Condition:   Emphysema
Interventions:   Drug: Placebo;   Drug: RAR Gamma
Sponsor:   Hoffmann-La Roche
Completed - verified November 2016

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