Emphysema



Site and Mechanism(s) of Expiratory Airflow Limitation in COPD, Emphysema and Asthma-COPD Overlap


Conditions:   COPD, Emphysema, Asthma COPD Overlap;   Emphysema
Intervention:   Other: As above: diagnosis: COPD, Emphysema, Asthma-COPD Overlap
Sponsor:   Gelb, Arthur F., M.D.
Recruiting


Belimumab Treatment of Emphysema Patients With Anti-GRP78 Autoantibodies


Conditions:   Chronic Obstructive Pulmonary Disease;   Emphysema
Interventions:   Biological: Belimumab;   Drug: Placebo
Sponsors:   University of Alabama at Birmingham;   GlaxoSmithKline
Not yet recruiting


Chartis Collateral Ventilation Measurement: Conscious Sedation Versus General Anesthesia


Condition:   Emphysema or COPD
Intervention:   Other: Type of sedation used
Sponsor:   University Medical Center Groningen
Not yet recruiting


Efficacy/Safety of HA Inhalation Solution for Hereditary Emphysema in Patients With Alpha-1 Antitrypsin Deficiency


Conditions:   Emphysema;   Alpha 1-Antitrypsin Deficiency
Interventions:   Drug: Hyaluronic Acid Inhalation Solution;   Drug: Placebo Inhalation Solution
Sponsor:   Gerard Turino
Recruiting


LVR in Severe Emphysema Using Bronchoscopic Autologous Blood Instillation in Combination With Intra-bronchial Valves


Conditions:   Chronic Obstructive Pulmonary Disease;   Emphysema
Intervention:   Device: Intra-bronchial valve and blood
Sponsor:   Royal Brompton & Harefield NHS Foundation Trust
Not yet recruiting


Spiration Valve System 9 mm European Post Market Evaluation Study


Condition:   Emphysema
Intervention:   Device: Implementation of 9 mm intrabronchial valves
Sponsors:   Heidelberg University;   Lung Clinic Hemer;   Asklepios Kliniken Hamburg GmbH;   Otto Wagner Hospital
Recruiting


REACH SVS Control Patient Cross-Over Study


Condition:   Emphysema
Intervention:   Device: Spiration Valve System
Sponsor:   Spiration, Inc.
Active, not recruiting


Clinical Study to Evaluate the Exercise Capacity in Patients With Severe Emphysema Treated With Coils


Condition:   Pulmonary Emphysema
Interventions:   Procedure: 10 coils in upper lobes;   Procedure: 15 coils in upper and lower lobes;   Procedure: cycloergometry
Sponsor:   Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Recruiting


Longitudinal Follow up to Assess Biomarkers Predictive of Emphysema Progression in Patients With COPD (Chronic Obstructive Pulmonary Disease)


Conditions:   Pulmonary Disease, Chronic Obstructive;   Pulmonary Emphysema
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting


Losartan Effects on Emphysema Progression


Condition:   Emphysema
Interventions:   Drug: Losartan;   Drug: Placebo
Sponsors:   Johns Hopkins University;   University of Pittsburgh
Recruiting


Functional CT Assessment of Pulmonary Arterial Dysfunction in Smoking Associated Emphysema


Condition:   Emphysema
Interventions:   Drug: Tadalafil;   Drug: Sildenafil
Sponsors:   University of Iowa;   National Institutes of Health (NIH);   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting


A Prospective Multicenter Clinical Study to Evaluate the Safety and Effectiveness of the OL-BF-001 for Severe Emphysema


Condition:   Emphysema
Intervention:   Device: OL-BF-001
Sponsor:   Olympus Corporation
Recruiting


To Improve Lung Function and Symptoms for Emphysema Patients Using Zephyr EBV


Conditions:   COPD;   Heterogeneous Emphysema
Intervention:   Device: ELVR (Endoscopic Lung Volume Reduction) with Zephyr valve
Sponsor:   Pulmonx, Inc.
Active, not recruiting


A Safety and Feasibility Study of Re-treating Patients With Severe Emphysema With the RePneu LVRC System.


Conditions:   COPD;   Emphysema
Intervention:   Device: Bronchoscopic lung volume reduction
Sponsor:   University Medical Center Groningen
Completed


Prostaglandin Inhibition for Emphysema


Condition:   Emphysema
Interventions:   Drug: 600 mg ibuprofen three times daily for 48 weeks;   Other: Placebo three times daily
Sponsors:   University of Nebraska;   National Jewish Health;   Temple University;   University of California, Los Angeles;   University of Alabama at Birmingham
Active, not recruiting


Efficacy and Safety of Alpha1-Proteinase Inhibitor (Human), Modified Process (Alpha-1 MP) in Subjects With Pulmonary Emphysema Due to Alpha1 Antitrypsin Deficiency (AATD)


Condition:   Pulmonary Emphysema in Alpha-1 PI Deficiency
Interventions:   Biological: Alpha1-proteinase inhibitor (human), modified process (Alpha-1 MP);   Other: 0.9% Sodium Chloride for Injection, USP
Sponsor:   Grifols Therapeutics Inc.
Recruiting


The Effect and Mechanism of Bronchoscopic Lung Volume Reduction by Endobronchial Valve in Korean Emphysema Patients


Condition:   Pulmonary Emphysema
Intervention:   Device: Endobronchial valve
Sponsor:   Asan Medical Center
Completed


Evaluation of the Spiration® Valve System for Emphysema to Improve Lung Function


Condition:   Emphysema
Interventions:   Device: Spiration Valve System;   Other: Medical Management
Sponsor:   Spiration, Inc.
Active, not recruiting


Pulmonx Endobronchial Valves Used in Treatment of Emphysema (LIBERATE Study)


Condition:   Emphysema
Interventions:   Device: EBV;   Other: Optimal Medical Management
Sponsor:   Pulmonx, Inc.
Active, not recruiting


Lung Volume Reduction Coil Treatment in Patients With Emphysema (RENEW) Study


Condition:   Emphysema
Intervention:   Device: RePneu Lung Volume Reduction Coil System
Sponsor:   PneumRx, Inc.
Active, not recruiting


Long Term Follow up Investigation of Endobronchial Valves in Emphysema


Condition:   Pulmonary Emphysema
Intervention:   Device: Zephyr Endobronchial Valve (EBV)
Sponsor:   Pulmonx International Sàrl
Terminated


A Study of the Use of Chartis System to Optimize Subject Selection for Endobronchial Lung Volume Reduction (ELVR)


Condition:   Emphysema
Interventions:   Device: Chartis System;   Device: Endobronchial Valve (EBV) Treatment
Sponsor:   Pulmonx, Inc.
Completed


EUROPT Clinical Trial to Study the Efficacy of One-Way Valve Implantation (New Treatment Algorithm) in Patients With Heterogeneous Emphysema


Conditions:   Emphysema;   Chronic Obstructive Pulmonary Disease
Intervention:   Procedure: Bronchoscopic Lung Volume Reduction (BLVR)
Sponsor:   LudwLudwig Boltzmann Institute for COPD and Respiratory Epidemiology
Unknown status


Clinical Trial to Evaluate the Safety and Effectiveness of the IBV® Valve System for the Treatment of Severe Emphysema


Conditions:   Emphysema;   COPD
Intervention:   Device: IBV® Valve System
Sponsor:   Spiration, Inc.
Completed


TESRA: (Treatment of Emphysema With a Gamma-Selective Retinoid Agonist)


Condition:   Emphysema
Interventions:   Drug: Placebo;   Drug: RAR Gamma
Sponsor:   Hoffmann-La Roche
Completed

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