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A Trial on the Effects of Bronchoscopic Lung Volume Reduction in Severe Emphysema.
Condition: Emphysema
Interventions: Behavioral: Pulmonary rehabilitation; Device: EBV treatment
Sponsors: University Medical Center Groningen; Maastricht University Medical Center
Not yet recruiting
Smoking Cessation and Functional CT Assessment
Condition: Emphysema
Interventions: Drug: Sildenafil 20 MG; Drug: Placebo Oral Tablet
Sponsors: Eric A. Hoffman; National Institutes of Health (NIH); National Heart, Lung, and Blood Institute (NHLBI)
Recruiting
Study of PneumRx Endobronchial Coil System in Treatment of Subjects With Severe Emphysema
Condition: Emphysema
Intervention: Device: Endobronchial Coils
Sponsor: PneumRx, Inc.
Not yet recruiting
Condition: Emphysema or COPD
Intervention: Device: Bronchoscopic thermal vapor ablation
Sponsors: Uptake Medical Technology, Inc.; acromion GmbH
Not yet recruiting
Site and Mechanism(s) of Expiratory Airflow Limitation in COPD, Emphysema and Asthma-COPD Overlap
Conditions: COPD, Emphysema, Asthma COPD Overlap; Emphysema
Intervention: Other: As above: diagnosis: COPD, Emphysema, Asthma-COPD Overlap
Sponsor: Gelb, Arthur F., M.D.
Recruiting
Belimumab Treatment of Emphysema Patients With Anti-GRP78 Autoantibodies
Conditions: Chronic Obstructive Pulmonary Disease; Emphysema
Interventions: Biological: Belimumab; Drug: Placebo
Sponsors: University of Alabama at Birmingham; GlaxoSmithKline
Not yet recruiting
Chartis Collateral Ventilation Measurement: Conscious Sedation Versus General Anesthesia
Condition: Emphysema or COPD
Intervention: Other: Type of sedation used
Sponsor: University Medical Center Groningen
Recruiting
Conditions: Emphysema; Alpha 1-Antitrypsin Deficiency
Interventions: Drug: Hyaluronic Acid Inhalation Solution; Drug: Placebo Inhalation Solution
Sponsor: Gerard Turino
Recruiting
Conditions: Chronic Obstructive Pulmonary Disease; Emphysema
Intervention: Device: Intra-bronchial valve and blood
Sponsor: Royal Brompton & Harefield NHS Foundation Trust
Recruiting
REACH SVS Control Patient Cross-Over Study
Condition: Emphysema
Intervention: Device: Spiration Valve System
Sponsor: Spiration, Inc.
Active, not recruiting
Condition: Pulmonary Emphysema
Interventions: Procedure: 10 coils in upper lobes; Procedure: 15 coils in upper and lower lobes; Procedure: cycloergometry
Sponsor: Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Recruiting
Losartan Effects on Emphysema Progression
Condition: Emphysema
Interventions: Drug: Losartan; Drug: Placebo
Sponsors: Johns Hopkins University; University of Pittsburgh
Recruiting
Functional CT Assessment of Pulmonary Arterial Dysfunction in Smoking Associated Emphysema
Condition: Emphysema
Intervention: Drug: Sildenafil
Sponsors: Eric A. Hoffman; National Institutes of Health (NIH); National Heart, Lung, and Blood Institute (NHLBI)
Recruiting
Condition: Emphysema
Intervention: Device: OL-BF-001
Sponsor: Olympus Corporation
Recruiting
Conditions: COPD; Emphysema
Intervention: Device: Bronchoscopic lung volume reduction
Sponsor: University Medical Center Groningen
Completed
Prostaglandin Inhibition for Emphysema
Condition: Emphysema
Interventions: Drug: 600 mg ibuprofen three times daily for 48 weeks; Other: Placebo three times daily
Sponsors: University of Nebraska; National Jewish Health; Temple University; University of California, Los Angeles; University of Alabama at Birmingham
Active, not recruiting
Condition: Pulmonary Emphysema in Alpha-1 PI Deficiency
Interventions: Biological: Alpha-1 MP; Other: 0.9% Sodium Chloride for Injection, USP
Sponsor: Grifols Therapeutics LLC
Recruiting
Condition: Pulmonary Emphysema
Intervention: Device: Endobronchial valve
Sponsor: Asan Medical Center
Completed
Condition: Pulmonary Emphysema
Interventions: Biological: Mesenchymal stem cells; Other: Reference therapy: 400 mL of 0.9% NaCl solution
Sponsor: Federal Research Clinical Center of Federal Medical & Biological Agency, Russia
Withdrawn
Evaluation of the Spiration® Valve System for Emphysema to Improve Lung Function
Condition: Emphysema
Interventions: Device: Spiration Valve System; Other: Medical Management
Sponsor: Spiration, Inc.
Active, not recruiting
Pulmonx Endobronchial Valves Used in Treatment of Emphysema (LIBERATE Study)
Condition: Emphysema
Interventions: Device: EBV; Other: Optimal Medical Management
Sponsor: Pulmonx, Inc.
Active, not recruiting
Lung Volume Reduction Coil Treatment in Patients With Emphysema (RENEW) Study
Condition: Emphysema
Intervention: Device: RePneu Lung Volume Reduction Coil System
Sponsor: PneumRx, Inc.
Active, not recruiting
Long Term Follow up Investigation of Endobronchial Valves in Emphysema
Condition: Pulmonary Emphysema
Intervention: Device: Zephyr Endobronchial Valve (EBV)
Sponsor: Pulmonx International Sàrl
Terminated
Condition: Emphysema
Interventions: Device: Chartis System; Device: Endobronchial Valve (EBV) Treatment
Sponsor: Pulmonx, Inc.
Completed
Conditions: Emphysema; COPD
Intervention: Device: IBV® Valve System
Sponsor: Spiration, Inc.
Completed