COPD

Join Clinical Trials for Chronic Obstructive Pulmonary Disease

Join Clinical Trials for COPD

Purpose: Chronic obstructive pulmonary disease (COPD) is an over-arching term used to describe two progressive lung diseases: chronic bronchitis and emphysema. If you suffer from COPD, you understand firsthand how difficult breathing can be.

For those who suffer from chronic bronchitis, the chronic inflammation of your airways and constant, excessive mucus production result in a nagging cough and persistent congestion, which makes breathing literally a chore.

If you have emphysema, the damage to the tiny air sacs in your lungs decreases your ability to get oxygen and can make it feel as if you are suffocating, or for some people, unable to fully exhale. Unfortunately, most individuals with COPD suffer from both chronic bronchitis and emphysema, which is a tough burden to bear.

Fortunately, there is considerable research ongoing that seeks to develop newer and more effective ways of treating the symptoms associated with COPD. This new research may one day provide newer and more effective medications to help reduce airway inflammation, control mucus production, and improve oxygen flow to the body.

Continued … COPD Clinical Trials (Click to Open)

Join Clinical Trials for COPD

What Will COPD Clinical Trials Be Like?

When participating in a clinical trial designed to investigate COPD, a few common tests and procedures may be involved; however, the ultimate design of the particular study will determine which specific procedures you will undergo. A physical exam may be performed so that the study doctor can listen to your lungs for wheezing and other abnormal sounds.Join Clinical Trials for COPD

Lung function tests may also be required to measure how efficiently you move air into and out of your lungs, as well as how well your lungs deliver oxygen to your blood. The main lung function test used for patients with COPD is known as spirometry.

During spirometry, you take a deep breath and then blow as hard as you can into a tube that is connected to a small machine known as a spirometer. The spirometer measures how much air you breathed out, and how fast.

Additional tests and procedures that might be involved in COPD-related clinical trials include: chest X-ray or CT-scan, which are both imaging tests that create detailed pictures of areas inside your body; and blood tests to determine the levels of oxygen and carbon dioxide present in your blood. In addition, you may be asked to use inhalers or other types of respiratory therapies, depending on the nature of the study.

Typical COPD Clinical Trial Protocol:

Research related to COPD covers a wide range of topics. Specific examples might include the following types of studies:

  • A study designed to investigate how a newly-developed medicine or other therapy improves the quality of life for COPD patients.
  • A study designed to investigate what factors lead to the development, or worsening, of COPD symptoms. Such factors might include environmental factors, occupational exposures, allergens, genetic factors, or viruses and bacteria.
  • A study designed to determine if certain genetic mutations make individuals who smoke more likely to develop COPD than others.
  • A study designed to determine the effectiveness of regular aerobic exercise on the control of COPD symptoms and individuals’ quality of life.

Suggested Search Terms:

“COPD exacerbation,” “COPD rehabilitation,” “COPD therapy,” “COPD asthma,” “COPD exercise,” “COPD genetics,” and “COPD smoking.” “Emphysema.” “Chronic Bronchitis”

If you have been diagnosed with only emphysema or chronic bronchitis and would like to refine your search further, you might consider substituting either “emphysema” or “chronic bronchitis,” (depending on your particular diagnosis) for COPD in the suggested search terms listed above.

Current Search Term:

COPD



Diagnostic and Therapeutic Approaches to Hyperinflation and Small Airway Disease in COPD


Condition:   COPD
Interventions:   Drug: mono bronchodilatation;   Drug: dual bronchodilatation
Sponsor:   Universitätsmedizin Mannheim
Not yet recruiting


THE FACTORS AFFECTING THE ADHERENCE TO THE PULMONARY REHABILITATION PROGRAM IN COPD


Condition:   COPD
Intervention:  
Sponsor:   Izmir Katip Celebi University
Completed


Long-term Effects of a 3-month Pedometer-based Program to Enhance Physical Activity in Patients With Severe COPD


Condition:   COPD
Intervention:   Behavioral: Intervention
Sponsor:   University of Zurich
Recruiting


Screening for COPD in Primary Care: a Synergistic Approach - Dentists - Pharmacists -Physiotherapists - Nurses - Physicians


Condition:   COPD
Intervention:   Diagnostic Test: COPD screening
Sponsor:   University Hospital, Brest
Recruiting


Identifying Patients With the COPD-Asthma Overlap Phenotype: Therapeutic Implications


Condition:   COPD Asthma
Intervention:  
Sponsor:   Clalit Health Services
Recruiting


Exercise Training in Patients With Mild COPD


Condition:   COPD
Intervention:   Other: Exercise training
Sponsor:   Pontificia Universidad Catolica de Chile
Recruiting


Latin American Study of 24-hs Symptoms in Chronic Obstructive Pulmonary Disease (COPD) Patients; LASSYC Study


Condition:   Stable COPD Patients
Intervention:  
Sponsor:   AstraZeneca
Completed


Pilot Study Evaluating Feasibility and Benefits of Telemonitored NIV Treatment on COPD Patients


Condition:   COPD
Interventions:   Device: telemonitoring;   Device: sham telemonitoring
Sponsor:   ResMed
Active, not recruiting


Effect of Roflumilast on Airway Blood Flow as an Expression of Airway Inflammation in COPD


Condition:   COPD
Interventions:   Drug: SD placebo and MD roflumilast then MD placebo;   Drug: SD placebo and MD placebo then MD roflumilast;   Drug: SD roflumilast and MD placebo then MD roflumilast;   Drug: SD roflumilast and MD roflumilast then MD placebo
Sponsors:   University of Miami;   Forest Laboratories
Completed


A 28-Day Parallel Group Study of TD-4208 in Chronic Obstructive Pulmonary Disease (COPD)


Condition:   COPD
Interventions:   Drug: TD-4208;   Drug: Placebo
Sponsor:   Theravance Biopharma R & D, Inc.
Completed


An Open Label Placebo Study To Assess The Inhalation Profile Obtained By Acoustic Monitoring In COPD Patients Using The NEXThaler DPI


Condition:   COPD
Intervention:   Device: Inhalation through Chiesi NEXThaler DPI
Sponsor:   Chiesi Farmaceutici S.p.A.
Completed


A Phase II, 5-way Cross-over Study to Evaluate the Pharmacodynamics of "Nexthaler" Dry Powder Inhaler in COPD Patients


Condition:   COPD
Interventions:   Drug: CHF 1535 NEXThaler 800/48;   Drug: CHF 1535 NEXThaler 200/12;   Drug: CHF 1535 NEXThaler PLACEBO;   Drug: CHF 1535 pMDI 200/12;   Drug: CHF1535 pMDI 800/48
Sponsor:   Chiesi Farmaceutici S.p.A.
Completed


Study to Evaluate the Impact of the "PROactive Telecoaching Program" on Physical Activity in Patients With COPD.


Condition:   COPD
Interventions:   Device: Automated telehealth system;   Other: Usual care
Sponsors:   Novartis Pharmaceuticals;   Innovative Medicines Initiative
Withdrawn


Study to Evaluate the Efficacy and Safety of Glycopyrronium or Indacaterol Maleate and Glycopyrronium Bromide Fixed-dose Combination Regarding Symptoms and Health Status in Patients With Moderate COPD Switching From Treatment With Any Standard COPD Regimen


Condition:   COPD
Interventions:   Drug: Glycopyrronium;   Drug: SABA;   Drug: LABA;   Drug: Indacaterol maleate and glycopyrronium bromide;   Drug: LAMA;   Drug: SAMA;   Drug: ICS
Sponsor:   Novartis Pharmaceuticals
Completed


Effects of Roflumilast in Hospitalized Chronic Obstructive Pulmonary Disease( COPD) on Mortality and Re-hospitalization


Condition:   COPD
Interventions:   Drug: Roflumilast;   Drug: Placebo
Sponsors:   Temple University;   Forest Laboratories
Active, not recruiting


Efficacy and Safety of AQX-1125 in Unstable COPD


Condition:   COPD
Interventions:   Drug: AQX-1125;   Drug: Placebo
Sponsor:   Aquinox Pharmaceuticals (Canada) Inc.
Completed


Lifestyle Physical Activity for People With COPD


Condition:   COPD
Intervention:   Behavioral: Lifestyle physical activity - self-efficacy
Sponsor:   University of Michigan
Completed


Comparison Between Levofloxacin and Prulifloxacin, in Internal Medicine Patients With Acute Exacerbation of COPD


Condition:   COPD Exacerbation
Interventions:   Drug: Levofloxacin 1 tablet 500 mg once a day;   Drug: Prulifloxacin 1 tablet 600 mg once a day
Sponsor:   Fadoi Foundation, Italy
Completed


Monitoring Chronic Obstructive Pulmonary Disease Patients at Home by a Forced Oscillation Technique Device


Condition:   COPD
Intervention:  
Sponsors:   Raffaele Dellaca;   Restech Srl;   Politecnico di Milano;   Fondazione Salvatore Maugeri;   Azienda Ospedaliera S. Luigi, Orbassano (TO);   Baylor College of Medicine;   Ospedale di Circolo e Fondazione Macchi, Varese;   Woolcock Institute of Medical Research
Recruiting


Broccoli Sprout Extracts Trial to See if NRF2 is Enhanced by Sulforaphane Treatment in Patients With COPD


Condition:   COPD
Interventions:   Drug: Sulforaphane 25;   Dietary Supplement: Sulforaphane 150;   Other: Placebo
Sponsors:   Johns Hopkins University;   Temple University;   State University of New York at Buffalo
Completed


Predictive Questionnaires for Risk of Acute COPD (Chronic Obstructive Pulmonary Disease) Exacerbations


Condition:   COPD
Intervention:  
Sponsor:   AstraZeneca
Completed


Differential Trough Effects of 'Triple Therapy' on Pulmonary Function in Chronic Obstructive Pulmonary Disease (COPD)


Condition:   COPD
Interventions:   Drug: Budesonide/formoterol and tiotropium;   Drug: Budesonide/formoterol and placebo
Sponsor:   Brian J Lipworth
Completed


Predictor for an Additional Benefit of Inhaled Corticosteroid in Patients Treated With Tiotropium for COPD


Condition:   COPD
Intervention:   Drug: Budesonide
Sponsor:   University Hospital, Basel, Switzerland
Unknown status


Comparing Fluticasone-Salmeterol in Chronic Obstructive Pulmonary Disease (COPD) and Sleep


Condition:   COPD
Interventions:   Drug: fluticasone/salmeterol 250/50;   Drug: placebo
Sponsors:   Penn State University;   GlaxoSmithKline
Unknown status


Home-based Treatment of Patients With Chronic Obstructive Pulmonary Disease (COPD)


Condition:   COPD
Interventions:   Behavioral: closer collaboration between hospital and primary healthcare system;   Behavioral: usual care
Sponsors:   St. Olavs Hospital;   Community Health Network
Completed

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