Chronic Bronchitis



VX-770 for the Treatment of Chronic Bronchitis


Condition:   Chronic Bronchitis
Intervention:   Drug: Ivacaftor (VX-770)
Sponsor:   University of Alabama at Birmingham
Not yet recruiting


Crossover Blinded Trial of Cell Therapy Versus Placebo in COPD


Conditions:   COPD;   Emphysema or COPD;   Chronic Bronchitis
Interventions:   Procedure: Treatment Then Placebo;   Procedure: Placebo Then Treatment
Sponsor:   Lung Institute
Enrolling by invitation


A Study of Andrographolide Sulfonate in Patients With Acute Exacerbation of Chronic Bronchitis


Condition:   Acute Exacerbation of Chronic Bronchitis
Interventions:   Drug: andrographolide sulfonate;   Drug: andrographolide sulfonate simulation
Sponsor:   Jiangxi Qingfeng Pharmaceutical Co. Ltd.
Recruiting


Gala FIH Feasibility Study for the Treatment of Chronic Bronchitis


Condition:   Chronic Bronchitis
Intervention:   Device: Gala Airway Treatment System
Sponsor:   Gala Therapeutics, Inc.
Recruiting


The Topic Trial - Study to Determine the Safety and Efficacy of Ivacaftor


Conditions:   Chronic Obstructive Pulmonary Disease;   Chronic Bronchitis
Interventions:   Drug: Ivacaftor 150 MG;   Drug: Placebo
Sponsors:   University of Alabama at Birmingham;   National Heart, Lung, and Blood Institute (NHLBI);   Vertex Pharmaceuticals Incorporated
Recruiting


The Effectiveness of Roflumilast in Improving Mucociliary Clearance in Patients With COPD and Chronic Bronchitis


Conditions:   COPD;   Chronic Bronchitis;   Emphysema
Interventions:   Drug: Roflumilast;   Drug: Placebo
Sponsor:   Johns Hopkins University
Completed


Studying the Airway Microenvironment in Patients Undergoing Surgical and Bronchoscopic Interventions for COPD


Conditions:   Chronic Obstructive Pulmonary Disease;   Emphysema;   Chronic Bronchitis
Intervention:  
Sponsor:   Royal Brompton & Harefield NHS Foundation Trust
Not yet recruiting


Acute Dyspnea After Use of Non-invasive Ventilation in COPD and Emphysema (Deventilation Syndrome)


Condition:   Obstructive Chronic Bronchitis
Intervention:  
Sponsor:   Felix JF Herth
Not yet recruiting


The Relationship Between GOLD Risk Group and Clinical Outcomes in a Community-based COPD Cohort


Conditions:   Chronic Obstructive Pulmonary Disease (COPD);   Emphysema;   Chronic Bronchitis
Intervention:  
Sponsors:   Duke University;   Boehringer Ingelheim
Recruiting


Safety and Feasibility Study of Rejuvenair™ for Treating Chronic Bronchitis Patients


Conditions:   Bronchitis, Chronic;   Cryotherapy Effect
Intervention:   Device: RejuvenAir
Sponsor:   CSA Medical, Inc.
Active, not recruiting


Effect of Losartan on Airway Mucociliary Dysfunction in Patients With COPD and Chronic Bronchitis


Conditions:   COPD;   Chronic Bronchitis
Interventions:   Drug: Losartan 50 mg;   Drug: losartan 100 mg
Sponsor:   University of Miami
Recruiting


Novel Therapies for Muco-Obstructive Lung Diseases: Testing the Transnasal Pulmonary Delivery Device in COPD/CB Subjects


Conditions:   COPD;   Chronic Bronchitis
Interventions:   Device: tPAD;   Device: 7% hypertonic saline (510K approved as a device)
Sponsor:   University of North Carolina, Chapel Hill
Withdrawn


Epidemiology of Chronic Bronchitis in Patients With Chronic Obstructive Pulmonary Disease (COPD)


Conditions:   Chronic Obstructive Pulmonary Disease;   Chronic Bronchitis
Intervention:  
Sponsor:   AstraZeneca
Completed


Respiratory Therapy in COPD Exacerbations


Condition:   Obstructive Chronic Bronchitis With Acute Exacerbation
Interventions:   Other: No Respiratory Therapy;   Other: Respiratory Therapy
Sponsor:   Parc de Salut Mar
Completed


The Effect of Physical Activity Promotion on Short and Long-term Outcomes in COPD


Conditions:   COPD;   Emphysema;   Chronic Bronchitis
Intervention:   Behavioral: Pedometer and Website
Sponsor:   VA Office of Research and Development
Recruiting


BI 113608 Administered as Tablets Twice Daily Over 4 Weeks in Patients With Chronic Obstructive Pulmonary Disease Associated With Chronic Bronchitis


Condition:   Pulmonary Disease, Chronic Obstructive
Interventions:   Drug: Placebo to BI 113608 high dose b.i.d.;   Drug: Placebo to BI 113608 low dose b.i.d.;   Drug: BI 113608 high dose b.i.d.;   Drug: Placebo to BI 113608 medium dose b.i.d.;   Drug: BI 113608 low dose b.i.d.;   Drug: BI 113608 medium dose b.i.d.
Sponsor:   Boehringer Ingelheim
Completed


Sustained Effects of Hypertonic Saline on Mucociliary Clearance in Subjects With Chronic Bronchitis


Conditions:   Chronic Obstructive Pulmonary Disease;   COPD;   Chronic Bronchitis
Intervention:   Other: Inhaled 7% HS (NaCl) home treatment
Sponsors:   University of North Carolina, Chapel Hill;   National Heart, Lung, and Blood Institute (NHLBI)
Completed


N-Acetylcysteine for Patients With COPD and Chronic Bronchitis


Conditions:   COPD;   Chronic Bronchitis
Interventions:   Drug: N-Acetylcysteine;   Drug: Placebo
Sponsor:   University of Minnesota - Clinical and Translational Science Institute
Terminated


N-Acetylcysteine for Patients With COPD and ChronicBronchitis


Conditions:   Chronic Obstructive Pulmonary Disease;   Chronic Bronchitis
Interventions:   Drug: N-acetylcysteine;   Drug: Oral acetylcysteine
Sponsor:   Minnesota Veterans Medical Research and Education Foundation
Unknown status


Ceftidoren Versus Levofloxacin in the Treatment of Patients With Acute Exacerbations of Chronic Bronchitis (AECB)


Condition:   COPD Exacerbation
Interventions:   Drug: ceftidoren;   Drug: levofloxacin
Sponsor:   University of Milan
Completed


Dietary and Genetic Factors in Asthma & Chronic Bronchitis in a Cohort of Chinese Singaporeans


Conditions:   Chronic Bronchitis;   Asthma
Intervention:  
Sponsor:   National Institute of Environmental Health Sciences (NIEHS)
Completed


Emphysema Research Registry


Conditions:   Emphysema;   Chronic Obstructive Pulmonary Disease;   Chronic Bronchitis
Intervention:  
Sponsor:   University of Pittsburgh
Recruiting


GW815SF For Chronic Obstructive Pulmonary Disease (Chronic Bronchitis, Emphysema)


Condition:   Pulmonary Disease, Chronic Obstructive
Intervention:   Drug: fluticasone propionate/salmeterol combination DISKUS
Sponsor:   GlaxoSmithKline
Completed


Evaluating Genes in Sputum to Measure Drug Response in COPD


Conditions:   Chronic Obstructive Pulmonary Disease (COPD);   Emphysema;   Chronic Bronchitis
Intervention:   Drug: Salmeterol or Salmeterol/Fluticasone
Sponsors:   National Jewish Health;   GlaxoSmithKline
Terminated


Airway Clearance for Prevention of COPD Exacerbation


Conditions:   COPD;   Chronic Bronchitis;   Emphysema
Intervention:   Device: pneumatic vest
Sponsors:   Johns Hopkins University;   Centers for Medicare and Medicaid Services;   Hill-Rom
Unknown status

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