Down Syndrome



Physiological Abnormalities Associated With Down Syndrome


Condition:   Down Syndrome
Intervention:  
Sponsors:   University of Arkansas;   Down Syndrome Research Foundation;   Arkansas Children Research Institute
Not yet recruiting - verified March 2017


Effects of Karate in Adolescents With Down Syndrome


Condition:   Down Syndrome
Intervention:   Other: PKSA karate class
Sponsors:   University of Michigan;   Down Syndrome Association of Toledo
Not yet recruiting - verified March 2017


Assessing the Feasibility of the Use of Visual Aids in Patient Education in Adults With Down Syndrome (DS)


Condition:   Down Syndrome
Interventions:   Behavioral: Verbal instructions with picture diagram;   Behavioral: Verbal instructions with video of ADSC;   Behavioral: verbal instructions w. video of w/o DS;   Behavioral: verbal instructions w. video w/DS
Sponsor:   Advocate Health Care
Active, not recruiting - verified February 2017


Performance Analysis in Down Syndrome on Mobile Phone


Condition:   Down Syndrome
Interventions:   Behavioral: Down Syndrome Group 1;   Behavioral: Down Syndrome Group 2;   Behavioral: Typical Development Group 1;   Behavioral: Typical Development Group 2
Sponsor:   University of Sao Paulo
Completed - verified April 2017


Safety, Tolerability and Immunogenicity of ACI-24 Vaccine in Adults With Down Syndrome


Condition:   Down Syndrome
Interventions:   Biological: ACI-24 low dose;   Biological: ACI-24 high dose;   Biological: Placebo
Sponsors:   AC Immune SA;   National Institute on Aging (NIA);   Alzheimer's Disease Cooperative Study (ADCS);   LuMind Research Down Syndrome Foundation
Recruiting - verified May 2017


Treatment of Sleep Disturbances in School-age Children With Down Syndrome


Condition:   Down Syndrome
Interventions:   Behavioral: Behavioral Sleep Treatment;   Behavioral: Standard of care sleep treatment enhanced with psychoeducation
Sponsor:   Children's Hospital Medical Center, Cincinnati
Recruiting - verified December 2016


A Study of RO5186582 in Down Syndrome Among Children 6 to 11 Years of Age


Condition:   Down Syndrome
Interventions:   Drug: Placebo;   Drug: RO5186582
Sponsor:   Hoffmann-La Roche
Terminated - verified March 2017


Non-drug Study to Evaluate the Suitability of Neurocognitive Tests and Functioning Scales for the Measurement of Cognitive and Functioning Changes in Children With Down Syndrome


Condition:   Down Syndrome
Intervention:   Other: No Intervention
Sponsor:   Hoffmann-La Roche
Completed - verified November 2016


Non-drug Study to Assess the Suitability of Assessment Scales in Japanese Individuals With Down Syndrome Aged 6-30


Condition:   Down Syndrome
Intervention:  
Sponsor:   Chugai Pharmaceutical
Completed - verified July 2016


Investigation of the Safety of Intranasal Glulisine in Down Syndrome


Condition:   Down Syndrome
Interventions:   Drug: Insulin glulisine;   Drug: Saline
Sponsor:   HealthPartners Institute
Recruiting - verified April 2017


Down Syndrome Memantine Follow-up Study


Conditions:   Down Syndrome;   Intellectual Disability
Interventions:   Drug: Memantine;   Drug: Placebo
Sponsors:   University Hospitals Cleveland Medical Center;   Alana USA Foundation
Recruiting - verified April 2017


Comparison of Bispectral Index Values in Patients With and Without Down's Syndrome


Condition:   Down Syndrome
Intervention:   Device: monitoring BIS in both groups
Sponsor:   Milton S. Hershey Medical Center
Recruiting - verified January 2017


Phenotypic Specific Communication Intervention for Children With Down Syndrome


Conditions:   Language Impairment;   Down Syndrome
Intervention:   Behavioral: Jasper-EMT with words and AAC
Sponsors:   Vanderbilt University;   University of California, Los Angeles
Recruiting - verified April 2017


Down Syndrome Biomarker Initiative (DSBI)


Conditions:   Down Syndrome;   Alzheimer's Disease
Intervention:  
Sponsors:   Michael Rafii;   Janssen Research & Development, LLC
Completed - verified May 2017


A Study of RG1662 in Adults and Adolescents With Down Syndrome (CLEMATIS)


Condition:   Down Syndrome
Interventions:   Drug: Placebo;   Drug: RG1662;   Drug: RG1662
Sponsor:   Hoffmann-La Roche
Completed - verified November 2016


DS-Connect {TM}: The Down Syndrome Registry


Condition:   Down Syndrome
Intervention:  
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Suspended - verified May 9, 2017


A Screening Protocol to Assess Adults and Adolescents With Down Syndrome for Eligibility For Upcoming Study of RG1662 (Study BP27832)


Condition:   Down Syndrome
Intervention:  
Sponsor:   Hoffmann-La Roche
Completed - verified November 2016


Treatment Trial of Subclinical Hypothyroidism in Down Syndrome


Conditions:   Down Syndrome;   Subclinical Hypothyroidism
Intervention:   Drug: Levothyroxine
Sponsors:   Children's Hospital of Philadelphia;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified November 2016


Down Syndrome Metabolic Health Study


Conditions:   Down Syndrome;   Trisomy 21
Intervention:  
Sponsors:   Children's Hospital of Philadelphia;   National Institutes of Health (NIH);   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified November 2016


Trisomy 21 in Adulthood


Condition:   Down Syndrome
Intervention:   Genetic: karyotype
Sponsor:   University Hospital, Strasbourg, France
Recruiting - verified November 2016


Natural History of Amyloid Deposition in Adults With Down Syndrome


Condition:   Down Syndrome
Intervention:  
Sponsors:   University of Pittsburgh;   National Institute on Aging (NIA)
Active, not recruiting - verified October 2016


Assessment of Bone Density and Bone Turnover Markers in Patients With Down Syndrome and Comparison to the Ts65Dn Model


Condition:   Down Syndrome
Intervention:   Other: Skeletal Status Assessment of a Down Syndrome Population
Sponsor:   University of Arkansas
Completed - verified December 2016


Frequency of Metabolic Syndrome in Down Syndrome Patients


Conditions:   Metabolic Syndrome X;   Down Syndrome
Intervention:  
Sponsor:   Universidad de Guanajuato
Completed - verified May 2017


Evaluating The Efficacy And Safety Of Donepezil Hydrochloride (Aricept) In The Treatment Of The Cognitive Dysfunction Exhibited By Children With Down Syndrome, Aged 6 To 10


Conditions:   Down Syndrome;   Cognitive Dysfunction
Interventions:   Drug: Aricept (Donepezil hydrochloride);   Drug: Placebo
Sponsors:   Eisai Inc.;   Pfizer
Terminated - verified February 2017


The Experience of Caregivers of Children With Down Syndrome


Condition:   Down Syndrome
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Completed - verified February 3, 2014

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